Journal articles: 'Sertraline HCl'

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Rajendran, Vijaya. "Effect of niosomes in the transdermal delivery of antidepressant sertraline hydrochloride." Journal of Scientific and Innovative Research 5, no. 4 (2016): 138–43. http://dx.doi.org/10.31254/jsir.2016.5408.

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Objective: Sertraline hydrochloride is an antidepressant that undergoes hepatic first pass effect upon oral administration. Controlled delivery for prolonged period across skin is one of the solutions to improve its therapeutic efficacy. Here, niosomes has been used as a carrier for the transdermal transport of sertraline HCl. Material and Method: Sertraline HCl Niosomes were prepared by ether injection method using surfactants such as span 40(A), span 60(B) and span 80(C) along with cholesterol at a ratio of 1:1. Four different concentrations (200:200(Aa), 250:250(Ab), 300:300(Ac) & 350:350(Ad)) of surfactant and cholesterol were used for each surfactant. The niosomes were characterized in vitro for size and surface morphology by means of particle size analyzer and scanning electron microscope (SEM) respectively. Encapsulation efficiency was determined by high performance liquid chromatography. Sertraline HCl release and skin permeation studies were carried out using franz diffusion cell. At last, the optimized formulation was subjected to physical stability studies. Results: The SEM and size distribution analysis evidenced the formation of discrete, spherical niosomes. Higher encapsulation efficiency of 53.71%±3.2%, 51.18%±2.5% and 51.92%±2.7% were obtained for Ad, Bb and Bc respectively. A maximum sertraline HCl release of 70%±2.6% was obtained for Ad which showed a permeation of 2.71%±0.157% across mouse skin. A calculated 50.2%±0.9% of sertraline HCl was assumed to get accumulated in the skin layers and the niosomes were physically stable. Conclusion: Sertraline HCl niosome showed a slow and prolonged release of sertraline HCl through the mouse skin and thus holds promise for transdermal delivery.

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H. Samein, Laith, Ahmed A. Hussein, Alaa A. Abdulrasool, and Jabar A. Faraj. "Preparation and Characterization of Biodegradable Microspheres Containing Sertraline Hydrochloride." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 17, no. 1 (2017): 64–71. http://dx.doi.org/10.31351/vol17iss1pp64-71.

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Four batches of sertraline HCl microspheres were prepared using a poly (D-L-lactide-co-glycolide) (PLGA) polymer ( Mw. 9, 27, 30 and 83 KDa) as a delivery system. The microspheres were prepared by a dispersion/solvent extraction-evaporation method and characterized for drug loading by UV, particle size by laser diffractometry and surface morphology by scanning electron microscopy (SEM). The in vitro sertraline HCl release was studied. Spherical microspheres with a mean diameter of 21 to 26 Âµm loaded with 24.6 â€“ 38.2% were produced. The in vitro drug release was shown to be depend on polymer molecular weight and also on the drug loading. Differential scanning calorimetry (DSC) was employed to investigate the physical state of sertraline HCl inside the microspheres and stability and polymer interaction study were performed in solution. Key words: Sertraline HCl , Microspheres , PLGA polymer

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Amira, M. Ghoneim. "Spray dried self-nanoemulsifying drug delivery systems for sertraline HCl: Pharmacokinetic study in healthy volunteers." Int J Pharm Sci Dev Res 4, no. 1 (2018): 009–19. https://doi.org/10.17352/ijpsdr.000017.

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Purpose: The aim of this study is to improvelow oral bioavailability of sertraline HCl by formulation and characterization ofsolid self-nanoemulsifying drug delivery system [SNEDDS] using spray drying technique. Methods: Solubility of sertraline HCl in different vehicles was determined, and ternary phase diagrams were constructed.Various formulations were prepared and characterized by morphological characterization, differential scanning calorimetry and droplet size analysis. The formulations were evaluated for in vitro release profile in comparison to the marketed product [Lustral® tablets]. The in vivo study was performed on healthy human volunteers for pharmacokinetic analysis of the optimized formulations.

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El-Enany, N., M. I. Walash, F. Belal, and H. El-Mansi. "Spectrophotometric Determination of the Antidepressants Sertraline and Paroxetine HCl using 2,4-Dinitrofluorobenzene." International Journal of Biomedical Science 6, no. 3 (2010): 252–59. http://dx.doi.org/10.59566/ijbs.2010.6252.

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A simple and sensitive spectrophotometric method was developed for the determination of each of sertraline (SER) and paroxetine HCl (PXT ) in dosage forms. The method is based upon reaction of PXT and SER with 2,4-dinitrofluorobenzene (DNFB) to form colored products. The absorbance of the products were measured at 375and 390 nm for SER and PXT respectively. The absorbance concentration plots were rectilinear over the concentration rang of 1-10 and 2-20 μg/mL with lower detection limits (LOD) of 0.11 and 0.28 μg/mL and quantification limits (LOQ) of 0.32 and 0.85 μg/mL for SER and PXT, respectively. The developed method was successfully applied for the determination of SER and PXT in dosage forms. The common excipients and additives did not interfere in their determinations. There was no significant difference between the results obtained by the proposed and the reference methods regarding Student t-test and the variance ratio F-test respectively. A proposal of the reaction pathway was postulated.

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Vahora, Shifa, Usmangani K. Chhalotiya, Hetaben Kachhiya, Jinal Tandel, and Dimal Shah. "Simultaneous quantification of brexpiprazole and sertraline HCl in synthetic mixture by thin-layer chromatography method." JPC – Journal of Planar Chromatography – Modern TLC 34, no. 6 (2021): 549–57. http://dx.doi.org/10.1007/s00764-021-00142-4.

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Nagy, Christa F., Dinesh Kumar, Carlos A. Perdomo, Suman Wason, Edward I. Cullen, and Raymond D. Pratt. "Concurrent administration of donepezil HCl and sertraline HCl in healthy volunteers: assessment of pharmacokinetic changes and safety following single and multiple oral doses." British Journal of Clinical Pharmacology 58, s1 (2004): 25–33. http://dx.doi.org/10.1111/j.1365-2125.2004.01801.x.

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Putri, Dina Christin Ayuning. "Profil peresepan dan analisis risiko racikan antidepresan di sebuah apotek di Yogyakarta." Health Sciences and Pharmacy Journal 7, no. 2 (2023): 62–71. http://dx.doi.org/10.32504/hspj.v7i2.803.

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In Yogyakarta, the number of patients suffering from depression reached 5.5%. To enhance the therapeutic benefit, psychiatrists frequently prescribe a combination of antidepressants to their patients. To identify the risk for incompatibility, the prescription profile of antidepressant medicines that are compounded together must be examined. The purpose of this study is to examine the prescribing patterns of compounded medications designated as antidepressants in a Yogyakarta pharmacy. The prescription is the research subject in this descriptive exploratory study. Prescriptions that satisfied the inclusion criteria were gathered, and the frequency of prescriptions was calculated. Two medications with the greatest prescribing frequency were then examined for potential interactions and incompatibility. Folic acid is the most commonly prescribed medicine when combined with another. It was formerly used with sertraline HCl, maprotiline HCl, trifluoperazine HCl, and diazepam. The psychiatrist was used to mixing three to four active drugs administered in capsules. The drug combination has various interactions that must be properly monitored. These findings can be used by the doctor to choose the best medicine combination.

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Tajani, Amine Sadat, Atoosa Haghighizadeh, Vahid Soheili, Salim Mirshahi, and Omid Rajabi. "In Vitro Bioequivalence Study of 8 Generic and 3 Brands of Sertraline-HCl Tablets in Iran Market." Biomedical and Pharmacology Journal 10, no. 3 (2017): 1109–16. http://dx.doi.org/10.13005/bpj/1210.

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Babu, Mannem Durga, and Kesana Surendra Babu. "GC-HS Method for Organic Volatile Impurities Determination and Quantification in Sertraline HCl API and Its Pharmaceutical Dosage Forms." Asian Journal of Chemistry 30, no. 8 (2018): 1791–95. http://dx.doi.org/10.14233/ajchem.2018.21311.

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Ashishkumar, Panpatil* Vedant Salunke Snehal Jadhav Faisal Shaikh Pravin Jadhav Vinod Bairagi Kaushik Kamble. "A Review On The Analytical Method Development And Validation Of Sertralinetablet By UV Spectroscopy." International Journal in Pharmaceutical Sciences 2, no. 4 (2024): 995–10002. https://doi.org/10.5281/zenodo.11061087.

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Sertraline HCl (SRT) in tablet and bulk dose form was estimated using an easy-to-use, reasonably priced, and precise UV technique. We dissolved SRT using water as a diluent. To increase the solubility of the medication combination, it was sonicated for three minutes. The absorptions at 228.0 nm were chosen for additional examination of SRT in tablet and bulk dose forms. The suggested approach was verified in compliance with ICH regulations. At 228.0 nm, the technique demonstrated great sensitivity, with a linearity range of 5 to 30 μg/mL (r2=0.999). The lowest concentration was found to be 4.08, indicating the limit of quantization (LOQ) and the limit of detection (LOD) to be 1.22. According to the findings, utilising UV spectroscopy to estimate SRT in bulk and tablet dosage form proved to be an easy, precise, accurate, and quick process.

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Boi, Basanta Kumar Reddy, Sahoo Nityananda, Prasad Padhy Rama, et al. "OPTIMIZATION OF AN ANTIDEPRESSANT DRUG LOADED SOLID LIPID NANOPARTICLES BY HOT HOMOGENIZATION TECHNIQUE WITH 32 FACTORIAL DESIGNS." COMMUNİTY PRACTİTİONER 20, no. 08 (2023): 254–65. https://doi.org/10.5281/zenodo.8285818.

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Abstract A revolutionary type of colloidal pharmaceutical delivery system has been invented, and in comparison, to the conventional dosage forms, it provides a number of benefits that cannot be found with the other options. Solid lipid nanoparticles, also known as SLN, offer a number of benefits, one of which is the ability to administer medications in a controlled and location-specific manner because to their utilisation. It is made up of a solid core and possesses a substantial drug content in its phospholipid cover up both of which contribute to boost its bioavailability. Additionally, the shell contains phospholipids. It is estimated that more than 200 million people around the world are afflicted with depression, which makes it the most widespread form of mental and emotional illness in the world. The symptoms of this illness include reduced concentration, a depressed mood, a loss of excitement in things that were previously enjoyable, feelings of shame or inadequate worth, disruptions in sleep or eating, and an inability to focus. Antidepressant drug containing sertraline monohydrate has the ability to target particular regions of the brain. To look into the impact which the formulation of those solid lipid nanoparticles possessed, in addition to the impact that the process variables had, on the efficacy of such established solid lipid nanoparticles was the primary objective of this work. Additionally, the formulation of strong lipid nanoparticles which were loaded with sertraline hydrochloride was one of the process variables that was investigated. In order to manufacture the solid lipid nanoparticles, a hot homogenization method was used, and 32 distinct factorial designs were incorporated into the research. In this study, the effects of various independent parameters on the amount of poloxamer 188 and glyceryl monosterate, as well as the effects of these factors on viscosity and drug release, were investigated. In order to evaluate the efficacy of the SLNs that were manufactured, they were loaded with sertraline hydrochloride. According to the data, the formulation known as SNF6 was the one that was the most successful. It had an entire entrapment efficiency of 91.32 ±2.35% and a drug release of 89.45 ±2.35% respectively. Enrichment of sertraline was accomplished by HCl entrapment, resulting in an adequate particle size and controlled release, as a direct result of the exhaustive screening inquiry. The factorial design was able to illustrate either the significance of it and it influence in determining and grasping the formulation and execution of the factors that influence the quality of SLNs. This was accomplished via the use of factorial arrangements.

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Atty, Shimaa A., Asmaa H. Ibrahim, Hany Ibrahim, Ahmed M. Abdelzaher, Ahmed M. Abdel-Raoof, and Fatma A. Fouad. "Simultaneous voltammetric detection of anti-depressant drug, sertraline HCl and paracetamol in biological fluid at CNT-cesium modified electrode in micellar media." Microchemical Journal 159 (December 2020): 105524. http://dx.doi.org/10.1016/j.microc.2020.105524.

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Prashant, S. Kharkar, P. Shah Chetan, and U. Sahu Niteshkumar. "Drug repurposing for Breast Cancer: Preliminary medicinal chemistry investigations and future perspectives." Journal of Indian Chemical Society Vol. 97, Aug 2020 (2020): 1245–50. https://doi.org/10.5281/zenodo.5656285.

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Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga (East), Mumbai-400 019, India Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, Vile Parle (West), Mumbai-400 056, India E-mail: ps.kharkar@ictmumbai.edu.in Manuscript received online 03 July 2020, accepted 30 July 2020 Triple-negative breast cancer (TNBC) is one of the leading causes of mortality in women. Despite the availability of varied treatment modalities, including chemotherapeutic and immunotherapeutic drugs, TNBC remains a major health concern worldwide. In the present study, we investigated the drug repurposing for TNBC with the hope to identify safer and efficacious drugs for its treatment. Of the 70 drugs tested against highly metastatic MDA-MB-231 cell line in MTT assay, a total of 11 drugs demonstrated potent cytotoxicity. Further in vitro and in vivo (animal efficacy) biological investigations are needed to prove the anti-TNBC potential of the identified hits – Domperidone, Candesartan cilexetil, Felodipine, Atorvastatin calcium, Sertraline HCl, Nisoldipine, Lopinavir, Clotrimazole, Desloratadine, Carvedilol phosphate and amlodipine besylate.

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Ozunal, Zeynep Gunes, Yaprak Donmez Cakil, Hatice Isan, Esra Saglam, and Ranan Gulhan Aktas. "Sertraline in combination with sorafenib: A promising pharmacotherapy to target both depressive disorders and hepatocellular cancer." Biologia Futura 70, no. 4 (2019): 341–48. http://dx.doi.org/10.1556/019.70.2019.39.

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Introduction Hepatocellular carcinoma (HCC) is found within the first five most common tumors worldwide. Sorafenib is an approved agent in HCC treatment. Sertraline is a selective serotonin reuptake inhibitor. The aim of the study is to investigate the combination of sertraline and sorafenib at hepatocellular cancer cell proliferation and death. Methods HepG2 cells were treated with drugs and viability test XTT was performed. Cells were stained with hematoxylin and eosin for histological examination or with anti-Bcl-2 antibody and Hoechst 33258 for immunofluorescence. Results Viability results supported dose-dependent antiproliferative effect for both sertraline and sorafenib. Microscopic evaluation of stained cells exerts morphological changes. Discussion This is the first study to show that sorafenib and sertraline have synergistic effect in hepatocellular cancer.

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Kang, Hyun-Ah, Hea-Young Cho, and Yong-Bok Lee. "Bioequivalence of Traline Tablet to Zoloft®Tablet (Sertraline HCI 50 mg)." Journal of Pharmaceutical Investigation 41, no. 5 (2011): 317–22. http://dx.doi.org/10.4333/kps.2011.41.5.317.

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Hangargekar, Sachin R., Pradeep K. Mohanty, and Janki Prasad Rai. "Preclinical Screening of Antidepressant Activity of Formulated Sertraline Hydrochloride-Loaded Solid Lipid Nanoparticles in Rats." Journal of Pharmaceutical Research International, September 29, 2021, 134–38. http://dx.doi.org/10.9734/jpri/2021/v33i45a32725.

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Objective: The main goal of our study was to investigate the antidepressant activity of Formulated Sertraline hydrochloride-loaded Solid Lipid Nanoparticles (SLNPs) by using a rat forced swimming test (FST) and tail suspension test (TST). Materials and Methods: Animals were divided into three groups, consisting of six rats in each group. Out of these, one group served as control that received distilled water, second group was standard received Sertraline HCl (20 mg/kg intranasal) and third group was received test formulation (SLNPs 50 mg/kg intranasal). To assess the effect of SLNPs on immobility activity through FST and TST were used to take as a measure of antidepressant activity. Results: SLNPs reduced the immobility duration in TST as well as in FST. In both methods, there was a statistical significant decrease in immobility of SLNPs group when compared to the control group. Conclusion: The results suggested that SLNPs produced significant antidepressant effect in rats which was comparable with control group and standard Sertraline HCl group animals.

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Amira M., Ghoneim. "Spray dried self-nanoemulsifying drug delivery systems for sertraline HCl: Pharmacokinetic study in healthy volunteers." International Journal of Pharmaceutical Sciences and Developmental Research, June 27, 2018, 009–19. http://dx.doi.org/10.17352/ijpsdr.000017.

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DIKSHA SHARMA and SHAWETA AGARAWAL. "FORMULATION AND EVALUATION OF IN SITU MUCOADHESIVE THERMOREVERSIBLE NASAL GEL OF SERTRALINE HYDROCHLORIDE." Asian Journal of Pharmaceutical and Clinical Research, October 29, 2019, 195–202. http://dx.doi.org/10.22159/ajpcr.2019.v12i11.35065.

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Objective: The objective of the study was to aiming to formulate and evaluate temperature based in situ nasal gel of sertraline HCL. Materials and Methods: Preformulation studies of sertraline hydrochloride including tests for identification, solubility studies, Fourier-transformer infrared (FTIR) spectroscopy, melting point determination, and other studies were carried out and compared with the specification as per literature. The solubility of sertraline hydrochloride was determined in different solvents such as in distilled water, ethanol, acetone, isopropyl alcohol, and 2-propanol. Each value for solubility was determined in triplicate and average values were reported. The drug excipient compatibility study was determined by FTIR. Thermal analysis was performed using a differential scanning calorimetric equipped with a computerized data station. The UV spectrum of sertraline hydrochloride was obtained using UV JascV630. The in situ gel formulation was prepared by changing the concentration and using only one polymer (Carbopol 934) has been used at the same concentration. Mucoadhesive strength and in vitro permeation study were determined using gout nasal mucosal membrane, whereas in vitro drug release study was carried out using diffusion cell through egg membrane as a biological membrane. The stability studies were conducted according to ICH guidelines. Results: The FTIR studies of formulation show no interaction between drug and excipient. In situ gel was prepared using Carbopol 934 and Poloxamer 407 to improve its adhesion property. The optimized formulation (F6) was transparent and clear in appearance with 101.15% drug content. The sol-gel transformation of in situ gel was found at temperature 34.92°C with immediate gelation property. The in vitro drug release of optimized formulation was found 95.80% drug release in 8 h. Formulations F4 and F6 showed immediate gelation within 60 s and remained stable for an extended period. All the formulations were liquid at room temperature and underwent rapid gelation on contact with simulated nasal fluid. Conclusion: The results concluded that the formulations of in situ nasal gel showing to improve the bioavailability through its longer residence time and ability to sustain drug release.

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Xiao, Xia, Conghui Wang, De Chang, et al. "Identification of Potent and Safe Antiviral Therapeutic Candidates Against SARS-CoV-2." Frontiers in Immunology 11 (November 25, 2020). http://dx.doi.org/10.3389/fimmu.2020.586572.

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COVID-19 pandemic has infected millions of people with mortality exceeding &gt;1 million. There is an urgent need to find therapeutic agents that can help clear the virus to prevent severe disease and death. Identifying effective and safer drugs can provide more options to treat COVID-19 infections either alone or in combination. Here, we performed a high throughput screening of approximately 1,700 US FDA-approved compounds to identify novel therapeutic agents that can effectively inhibit replication of coronaviruses including SARS-CoV-2. Our two-step screen first used a human coronavirus strain OC43 to identify compounds with anti-coronaviral activities. The effective compounds were then screened for their effectiveness in inhibiting SARS-CoV-2. These screens have identified 20 anti-SARS-CoV-2 drugs including previously reported compounds such as hydroxychloroquine, amlodipine besylate, arbidol hydrochloride, tilorone 2HCl, dronedarone hydrochloride, mefloquine, and thioridazine hydrochloride. Five of the newly identified drugs had a safety index (cytotoxic/effective concentration) of &gt;600, indicating a wide therapeutic window compared to hydroxychloroquine which had a safety index of 22 in similar experiments. Mechanistically, five of the effective compounds (fendiline HCl, monensin sodium salt, vortioxetine, sertraline HCl, and salifungin) were found to block SARS-CoV-2 S protein-mediated cell fusion. These FDA-approved compounds can provide much needed therapeutic options that we urgently need during the midst of the pandemic.

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"Analytical Method Development And Validation For Determination Of Nitrosamine Impurities N-Nitrosodibutylamine (Ndba) & Nitroso Of N-Dimethyl Erythromycin In Sertraline Hcl Drug Substance By Lc-Ms/Ms." Nanotechnology Perceptions 20, S14 (2024). http://dx.doi.org/10.62441/nano-ntp.v20is14.18.

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Sanjeev Kumar Giri and Upama Misra. "Analytical Method Development And Validation For Determination Of Nitrosamine Impurities N-Nitrosodibutylamine (Ndba) & Nitroso Of N-Dimethyl Erythromycin In Sertraline Hcl Drug Substance By Lc-Ms/Ms." Nanotechnology Perceptions, November 4, 2024, 291–311. https://doi.org/10.62441/nano-ntp.vi.2776.

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This work provides a thorough assessment of a method for measuring N-nitrosodibutylamine and N-nitroso of N-dimethyl erythromycin A, two substances with substantial regulatory interest because of their health hazards. The performance characteristics of the method were thoroughly investigated through a series of experiments, including standard solution analysis, quantitation and detection limit determination, linearity assessment, precision testing at various levels, and accuracy evaluation via recovery studies. The findings demonstrate that the technique performs exceptionally well in terms of linearity, accuracy, and precision over a broad range of concentrations. The results indicate that the suggested approach has the potential to accurately quantify these chemicals in a range of sample matrices, making it a useful tool for regulatory compliance and quality assurance in associated industries.

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Journal articles on the topic 'Sertraline HCl'

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