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Journal articles on the topic 'Serum enzymes (AST and ALPi)'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Mohmed, Ismaiel Hamdan Malek, Ahmed Mulhtar Mukhtar, and Abd Elbagi Mohammed Kamal. "Effect of diets supplemented with local concentrate as an alternative to the imported concentrate on the serum metabolites and enzymes of broiler chicks." GPH-International Journal of Agriculture and Research 8, no. 5 (2025): 01–08. https://doi.org/10.5281/zenodo.15429880.

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A total of 63 chicks 7 days old unsexed broiler chicks strain (Arber Acer) purchased from a local commercial hatchery Company (mico) were randomly divided into three treatments (A, B, and C,). Each treatment group was sub divided into three replicates of 7 chicks per each. Group A fed on Local concentrate 5 %, group B fed on Local concentrate 7.5 %, and group C, fed on control diet with imported concentrate 5%. The inclusion of local concentrate by all levels  improved significantly (p≤0.05)  on chicks serum metabolites (total protein, albumin, creatinine, uric acid, glucose, urea

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Uedeme-Naa, B, George, and A.D.I. "Relative Enzymes Activities in Selected Organs and Serum Plasma of Clarias gariepinus Juveniles and Adults Exposed to Chronic Levels of Detergent – Linear Alkylbenzene Sulfonate (LAS)." Pharmaceutical and Chemical Journal 6, no. 4 (2019): 65–73. https://doi.org/10.5281/zenodo.13941847.

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The effect of chronic concentrations of detergent on serum enzymes in the gills, muscle, kidney, liver and plasma of juvenile and adult mudfish, <em>Clarias gariepinus</em> (Burchell) was investigated under static bio-assays during a 30 days’ exposure period. Concentrations of detergent used were 0.00 (control), 10.00, 20.00, 30.00, 40.00 and 50.00mg/l. Relatively, it was observed that on exposure of serum enzymes in the gills, muscle, kidney, liver and plasma of juvenile and adult <em>Clarias gariepinus,</em> detergent altered: Aspartate aminotransferase (AST) activities in all the orga

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Gulnashi, Kumar Arun, Inamul Haque S.M., Singh Asha, and Kumar Mukesh. "To Assess the Effects of Atorvastatin on C-Reactive Protein, Glycaemic Status, and Liver Enzymes in Non-Diabetic Patients." International Journal of Pharmaceutical and Clinical Research 16, no. 3 (2024): 796–802. https://doi.org/10.5281/zenodo.10968243.

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<strong>Background: </strong>To assess the effects of Atorvastatin on C – reactive protein, Glycaemic Status, and Liver Enzymes in non-diabetic patients. <strong>Materials and Methods: </strong>The research involved 100 patients. Patients aged 28-72 years, who have not taken any drugs before, and are prescribed oral atorvastatin for dyslipidemia or for secondary prevention of cardiovascular or cerebrovascular illnesses were included in the research. All participants were receiving atorvastatin treatment and were monitored for one year, with a review of the mentioned parame

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Sulafa, Murgan, Eltom Abdelgadir, and L. Osman Ahmed. "Evaluation of serum activity of aspartate transaminase, alanine transaminase and alkaline phosphatases in Sudanese with long standing type 2 diabetes mellitus." GSC Biological and Pharmaceutical Sciences 12, no. 1 (2020): 168–75. https://doi.org/10.5281/zenodo.4269937.

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Background Diabetes, the most common non- communicable disease in Sudan, is having an increasing impact or rates of morbidity and mortality. The spread of sedentary lifestyle and adoption of western dietary habits-high in refine carbohydrates and fat- are driving an increase in the number of people with obesity related type 2 diabetes. The study aims to evaluate the plasma activities in enzymes (AST, ALT and ALP) in Sudanese with long standing diabetes mellitus type 2 compared with healthy subjects (non diabetics) as a control group. Method a cross-sectional study conducted during the period f

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Kolodkina, Elena, and Sergey Lytaev. "The Dynamics of Transaminase and Alkaline Phosphatase Activities in the “Mother–Placenta–Fetus” Functional System." Biomedicines 13, no. 3 (2025): 626. https://doi.org/10.3390/biomedicines13030626.

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Background: The timing of delivery depends on the condition of the fetus and the mother’s body, which is reflected in both the incretion of enzymes in the pregnant woman’s body and their use by the developing fetus in the anabolic process. The aim: This work was aimed to analyze the activities of transaminases (aspartate aminotransferase (AST) and alanine aminotransferase (ALT)) and alkaline phosphatase (AlPh) in liquid media (blood serum, amniotic fluid, umbilical cord blood, and placental homogenate) in pregnant women in each trimester of pregnancy and in the postpartum period, considering t

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Ridha, Hussein SH, and Zahraa H. M. Kadri. "Assessment of liver enzymes in saliva and serum of Iraqi patients with chronic periodontitis disease." Journal of Biotechnology Research Center 14, no. 1 (2020): 20–24. http://dx.doi.org/10.24126/jobrc.2020.14.1.584.

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Objective: The present study aimed to assess of four liver enzymes, Alanine Aminotransferase (ALT), Aspartate Transaminase (AST), Alkaline Phosphatase (ALP) and Gamma-Glutamyl Transpeptidase (GGT).  Material and Methods: Based on periodontal clinical parameters, sixty four patients with chronic periodontitis (CP) and twenty four controls were enrolled in the study. Saliva and serum samples were collected and Automated Chemistry Analyzer AU 480 was employed to assess levels of enzymes. Results: Compared to healthy controls, the levels of the four enzymes were significant increased in seru

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Rashed, Md Rakib, Sumayra Jhumu, Tania Sultana Zaman, and Mst Fatema Khatun. "Comparative Study on Serum Hepatic Enzymes between Normal Healthy Adults and Obese People of Rajshahi City." Ibrahim Cardiac Medical Journal 11, no. 1 (2022): 62–70. http://dx.doi.org/10.3329/icmj.v11i1.58708.

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Background & objective: Obesity is rapidly emerging as one of the major causes of non-alcoholic fatty liver disease (NAFLD), the early sign of which is elevated liver enzymes. But very few studies have yet been done in our country to find the association between overweight and obesity and levels of serum hepatic enzymes. The present study was undertaken to determine the association between overweight/obesity determined by body mass index (BMI) and serum hepatic enzymes. Methods: This cross-sectional analytical study was conducted in the Department of Physiology, Rajshahi Medical Coll

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Rascu, Agripina, Oana Cristina Arghir, Eugenia Naghi, and Marina Ruxandra Otelea. "Serum Aminotransferases and the Severity of Asthma." Revista de Chimie 69, no. 5 (2018): 1200–1202. http://dx.doi.org/10.37358/rc.18.5.6288.

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The serum enzymes are ideal diagnostic or prediction markers. Aspartate aminotransferase (AST), a mitochondrial and cytoplasmic enzyme, is one of the well-known markers of hepatic, myocardial or skeletal muscle cytolysis, while alanine aminotransferase (ALT) is mainly a hepatic cytoplasmic enzyme. The normal plasmatic values of AST and of ALT reflect a physiological cell turnover. Therefore, both high and low levels of serum liver enzymes might have a clinical significance. We have conducted a retrospective study targeting the association between the serum AST and ALT levels and the lung funct

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Alzeer, Abdulaziz H., Mohsen A. F. El-Hazmi, Arjumand S. Warsy, Ziauddin A. Ansari, and Mohammed S. Yrkendi. "Serum enzymes in heat stroke: prognostic implication." Clinical Chemistry 43, no. 7 (1997): 1182–87. http://dx.doi.org/10.1093/clinchem/43.7.1182.

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Abstract We measured serum creatine kinase (CK), lactate dehydrogenase (LD), aspartate aminotransferase (AST), and serum alanine aminotransferase (ALT) in 26 heat stroke (HS) victims and 10 control (non-heat-exhausted) subjects during annual Hajj in Makkah, Saudi Arabia. On admission to the HS treatment unit, serum CK, AST, ALT, and LD were higher in HS victims than controls (P &lt;0.05), and at 6, 12, and 24 h were higher than baseline concentration. The patient group was divided into three groups, (a) those who had a quick recovery, (b) those who were critically ill until the end of the

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Tomovska, Julijana, Gordana Dimitrovska, Stefce Presilski, and Kristina Velkova. "Whey and its inhibition of liver enzymes." Biotehnologija u stocarstvu 32, no. 1 (2016): 59–70. http://dx.doi.org/10.2298/bah1601059t.

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Whey is lately used as functional food, and whey proteins and albumens are considered to have therapeutic influence on diseases associated with oxidative stress. Whey proteins contribute to the reduction of the level of transaminases in blood, especially of alanine transaminase. In this paper we examine some components (total proteins, albumens from whey proteins, minerals: potassium (K), iron (Fe), calcium (Ca) and phosphorus (P), from whey and their inhibition effects to transaminases (alanine aminotransferase (ALT), aspartate aminotransferase (AST), and ? glutamyl transferase (? -GT)). The

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11

Kim, Hae, and Mi Han. "Association between Serum Liver Enzymes and Metabolic Syndrome in Korean Adults." International Journal of Environmental Research and Public Health 15, no. 8 (2018): 1658. http://dx.doi.org/10.3390/ijerph15081658.

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The purpose of this study was to evaluate the association between alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and metabolic syndrome (MS) in the Korean population. A total of 11,587 adults ≥30 years of age and with complete data were selected from Korea National Health and Nutrition Examination Survey VI conducted from 2013 to 2015. Normal ALT and AST levels were divided into quartiles, and their associations with MS were assessed by logistic regression analysis. Elevated levels of ALT [adjusted odds ratio (aOR) = 7.90, 95% confidence interval (CI) = 6.50–9.60] and AST

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Silivontchik, N. N., A. I. Lednik, O. P. Levchuk, and L. I. Plotnikova. "MACRO-ASPARTATE AMINOTRANSFERASE." Hepatology and Gastroenterology 5, no. 1 (2021): 25–29. http://dx.doi.org/10.25298/2616-5546-2021-5-1-25-29.

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Measurement of serum enzyme activity is one of the most common laboratory tests. Increased activity may be caused by abnormal enzymes with a high molecular mass, the so-called macroenzymes. Macroenzymes may be seen in healthy subjects, but can also be related to disease. Macro-aspartate aminotransferase (macro-AST) is a macroenzyme that results from an enzymatic complex consisting of AST linked to serum immunoglobulin (IgA, IgG or both). MacroAST persistence is a rare benign condition. Macro-AST is generally characterized by increased serum AST activity. The article contains analysis of litera

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AH., AL-Hadithy H. "Assessment of some liver enzyme activities in healthy Iraqi racing Horses." Iraqi Journal of Veterinary Medicine 35, no. 1 (2011): 76–80. http://dx.doi.org/10.30539/iraqijvm.v35i1.606.

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The current study was conducted for the measurement of normal range and mean value of serum alanine aminotransferase (ALT) , aspartate aminotransferase (AST) and alkaline phosphatase (ALP) in (125) clinically normal Iraqi racing horses (males and females , Arabian and Crossbred) , aged 2 – 8 years ; < 4 , 4 and > 4 age groups . The results revealed that the range and the mean value ± SEM of these enzymes were as follows ; serum ALT 2 – 28 U/L and 11.07 ± 0.62 U/L, serum AST 30 – 210 U/L and 78.00 ± 3.62 U/L and serum ALP 63 – 204 IU/L and 96.84 ± 2.52 IU/L respectively .However, signific

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14

Ramsay, Edward C., and Thomas K. Dotson. "Tissue and serum enzyme activities in the yellow rat snake (Elaphe obsoleta quadrivitatta)." American Journal of Veterinary Research 56, no. 4 (1995): 423–28. http://dx.doi.org/10.2460/ajvr.1995.56.04.423.

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Abstract Activities of diagnostically important enzymes were measured in serum and lysates of liver, kidney, skeletal muscle, heart, intestine, lung, and pancreatic tissues from wild-caught yellow rat snakes, Elaphe obsoleta quadrivitatta. All samples were analyzed for alkaline phosphatase, lactate dehydrogenase (ld), aspartate transaminase (ast), alanine transaminase, γ-glutamyltransferase, and creatine kinase (ck) activities. The major enzyme activities found in the liver were ld and ast. The kidney had moderate activities of ld, ast, alanine transaminase, and ck. Skeletal muscle and heart c

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Shinozaki, Satoshi, Toshiyuki Tahara, Kouichi Miura, Alan Kawarai Lefor, and Hironori Yamamoto. "Effectiveness of One-Year Pemafibrate Therapy on Non-Alcoholic Fatty Liver Disease Refractory to Long-Term Sodium Glucose Cotransporter-2 Inhibitor Therapy: A Pilot Study." Life 13, no. 6 (2023): 1327. http://dx.doi.org/10.3390/life13061327.

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Background: Both pemafibrate and sodium glucose cotransporter-2 (SGLT2) inhibitor can decrease serum transaminase levels in patients with non-alcoholic fatty liver disease (NAFLD) complicated with dyslipidemia and type 2 diabetes mellitus (T2DM), respectively. However, the effectiveness of combined therapy has been rarely reported. Methods: This is a two-center retrospective observational study. NAFLD patients complicated with T2DM treated with pemafibrate for >1 year were included, in whom prior treatment with SGLT2 inhibitor > 1 year failed to normalize serum alanine aminotransferase (

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16

Jindal, Himanshu, Abhilasha Singh, Rajan Goyal, and Abhishek Kamendu. "Observational Study of Serum Alanine Aminotransferase (ALT), Serum Aspartate Aminotransferase (AST) and Serum Alkaline Phosphatase (ALP) Levels in Type 2 Diabetic Patients." Journal of Evidence Based Medicine and Healthcare 7, no. 48 (2020): 2852–55. http://dx.doi.org/10.18410/jebmh/2020/584.

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BACKGROUND The relationship between liver enzymes like alanine aminotransferase (ALT), aspartate aminotransferase (AST), Alkaline phosphatase (ALP) and diabetes has been studied, but the results of these are inconsistent. Several prospective studies have reported that ALT was associated with incident diabetes. We wanted to study the levels of serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST) and serum alkaline phosphatase (ALP) in patients of Type 2 DM. METHODS This is a hospital based observational study which was conducted in Narayan Medical College and Hospital, J

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17

Panteghini, M., F. Pagani, and C. Cuccia. "Activity of serum aspartate aminotransferase isoenzymes in patients with acute myocardial infarction." Clinical Chemistry 33, no. 1 (1987): 67–71. http://dx.doi.org/10.1093/clinchem/33.1.67.

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Abstract Activities of aspartate aminotransferase (AST) isoenzymes were determined in serial serum samples from 40 cases of acute myocardial infarction, and compared with activities of creatine kinase, CK-MB isoenzyme, lactate dehydrogenase, and alpha-hydroxybutyrate dehydrogenase for temporal changes. Cytosolic (soluble) AST (s-AST) and mitochondrial AST (m-AST) respectively increased 6.6 and 9.0 h after onset of chest pain. The median time at which serum m-AST activity peaked (15.8 U/L, range 6.4-53.5 U/L) was 47.8 h after the onset of infarction, 19.8 h later than the peak s-AST activity (1

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Ebrahimpour, P., M. Karamian, and A. Sharifi. "Effects of Resveratrol on Liver Function Tests in Patients with Non-Alcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis of Randomized Controlled Trials." Russian Journal of Gastroenterology, Hepatology, Coloproctology 34, no. 1 (2024): 37–46. http://dx.doi.org/10.22416/1382-4376-2024-34-1-37-46.

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Background. Some studies have shown that resveratrol may prevent, delay, or treat liver damage. This study aimed to provide up-to-date evidence regarding the effect of resveratrol on the liver enzymes (ALT & AST) in NAFLD patients. We conducted a systematic review and meta-analysis to evaluate the effect of resveratrol on liver enzymes in patients with NAFLD by searching various databases for published RCTs.Methods. A systematic search in PubMed, Scopus, and Web of Science was performed up to September 2023. This systematic review and meta-analysis included all the RCT studies assessing re

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Han, Sang-Won, Sang-Hwa Lee, Jong Ho Kim, et al. "Association of Serum Liver Enzymes with Brain Amyloidopathy and Cognitive Performance." Journal of Alzheimer's Disease Reports 7, no. 1 (2023): 1465–74. http://dx.doi.org/10.3233/adr-230148.

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Background: Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ) plaque accumulation and neurofibrillary tangles in the brain. Emerging evidence has suggested potential interactions between the brain and periphery, particularly the liver, in regulating Aβ homeostasis. Objective: This study aimed to investigate the association of serum liver enzymes with brain amyloidopathy and cognitive performance in patients with complaints of cognitive decline. Methods: A total of 1,036 patients (mean age 74 years, 66.2% female) with subjective cognitive decline, mild cognitive impairment, AD dementi

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Fatema, K., D. Parvin, S. Islam, et al. "Serum Hepatic Enzymes Level in Type 2 Diabetes Mellitus in a Tertiary Level Hospital." Bangladesh Journal of Medical Biochemistry 10, no. 2 (2018): 58–63. http://dx.doi.org/10.3329/bjmb.v10i2.36701.

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Diabetes mellitus is one of the most common non-communicable diseases globally. Magnitude of DM in developing countries including Bangladesh is rising rapidly. Several studies across the world have reported the association of higher serum hepatic enzyme levels with type 2 DM which may be an expression of excess deposition of fat in the liver. Thus, serum hepatic enzyme levels may serve as a marker of insulin resistance in the liver and may predict the prognosis and complications in type 2 DM individuals. The present crosssectional study was conducted in the Department of Biochemistry, Dhaka Me

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Lodhi, Rashid, and Navanil Roy. "Liver function tests in patients of pre-eclampsia in Bhilai, Chhattisgarh, India: a clinical study." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 12 (2018): 5102. http://dx.doi.org/10.18203/2320-1770.ijrcog20184975.

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Background: Pre-eclampsia is a multisystem disorder, which occurs only in pregnant women during the second and third trimesters of pregnancy and is associated with raised blood pressure and proteinuria. Liver function Test (LFT) abnormalities occur in 3% of the pregnancies and probably the lesion that causes elevated serum liver enzymes. This study was conducted to compare the liver function tests in pre-eclampsia with normal pregnancy.Methods: This study was carried out on 60 pregnant women after 20 weeks of gestation admitted in Obstetrics and Gynaecology units of Shri Shankaracharya Institu

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Hussain, Ghufran, Maytham Abdullah, and Nibras Hussein. "Association of the changes in hepatic enzymes, bilirubin, and plasma proteins with beta-thalassemia in iron over loaded-patients." Journal of Advanced Biotechnology and Experimental Therapeutics 6, no. 2 (2023): 429. http://dx.doi.org/10.5455/jabet.2023.d138.

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Changes in liver enzymes and bilirubin in patients with thalassemia depend on genetic changes and the association of other genetic determinants. Iron overload is associated with increased morbidity in both transfusion-dependent and non-transfusion-dependent thalassemia patients. The main objective was to evaluate hepatic enzymes, bilirubin and plasma proteins in βTM patients and also to study the correlations of these parameters with serum hemoglobin and ferritin concentrations in βTM patients. To achieve this goal, the study was directed on two groups, the first is case group includes 39 pati

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Ferri, Evelyn, Paolo D. Rossi, Martina Scichilone, Tiziano A. Lucchi, and Beatrice Arosio. "Liver Enzymes in a Cohort of Community-Dwelling Older Persons: Focus on Sex Contribution." Nutrients 14, no. 23 (2022): 4973. http://dx.doi.org/10.3390/nu14234973.

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Dysfunctions in liver metabolic activities may increase the risk of cognitive impairment and dementia. In a cohort of community-dwelling older persons investigated for a suspected cognitive decline, we studied the association between liver status and dementia, considering sex and frailty contribution. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) concentrations, and the AST/ALT ratio were used to assess liver function in 419 older adults (248 persons with dementia and 171 age- and sex-matched subjects without cognitive decline). Although the serum concentrations of

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Saad-Hussein, A., MM Taha, NN Fadl, et al. "Effects of airborne Aspergillus on serum aflatoxin B1 and liver enzymes in workers handling wheat flour." Human & Experimental Toxicology 35, no. 1 (2015): 3–9. http://dx.doi.org/10.1177/0960327115573596.

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Objective: The present work aimed to investigate the relationship between occupational exposure to airborne molds, serum aflatoxin B1 (AFB1), and liver enzymes of workers handling wheat flour. Methods: The study included 90 bakers, 100 flour milling workers, and 100 controls with no exposure to flour dust. Workplace aspects such as temperature and relative humidity were measured. Airborne fungi were collected and identified. In all subjects included, the serum levels of AFB1, serum albumin (Alb), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) w

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Modawe, GadAllah. "Evaluation of Liver Enzymes Activities among Type 2 Diabetic Patients, Attending Alribat University Hospital, Khartoum State." Iraqi National Journal of Medicine 4, no. 2 (2022): 250–58. http://dx.doi.org/10.37319/iqnjm.4.2.9.

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Background: Diabetes mellitus is a metabolic disease known by chronic hyperglycemia which results from defective insulin action and secretion. Various studies have documented liver disease as a major cause of mortality in patients with type 2 diabetes. It is well known that the liver plays an important role in the maintenance of normal glucose levels during fasting as well as in the postprandial period Aim: To evaluate the levels of liver markers in type 2 diabetes patients in Khartoum state. Materials and Methods: The study was conducted in Alribat University hospital, Sudan during the period

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Ahmed, Bakhtiar Muhialdin. "Serum Muscle Enzymes as Indicator for Gingival Wound Healing in Rabbits Orally Receiving Pomegranate Peel Extract." Erbil Dental Journal 7, no. 2 (2024): 123–31. https://doi.org/10.15218/edj.2024.14.

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Background and Objectives: Pomegranate, Punica granatum, is known to possess a powerful ability for accelerating wound healing. The aim of this study is to evaluate serum muscle enzymes; Creatine phospho kinase (CPK), aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Lactate dehydrogenase (LDH) activities in gingival wound healing process in rabbits orally administrated pomegranate peel extract (PPE). Methods: This study included 55 rabbits that were divided into 3 groups; baseline group consisted of 5 rabbits without creating buccal gingival injury, and the study group incl

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Chanda, Manashe, Tapos Biswas, Molla Amiruzzaman, et al. "Association of Serum Uric Acid and Liver Enzymes in Adults at Tertiary Level Hospital in Bangladesh." Bangladesh Medical Journal 51, no. 3 (2024): 18–27. http://dx.doi.org/10.3329/bmj.v51i3.70173.

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The level of serum uric acid (SUA) has been linked to metabolic syndrome, diabetes, and cardiovascular disease. The purpose of this study was to evaluate the relationship between SUA and serum liver enzymes in a Bangladeshi adult population. This cross-sectional study was conducted among apparently healthy adults aged >18 years, from March 2019 to February 2020 at the Department of Biochemistry, Sir Salimullah Medical College (SSMC), Dhaka. SUA, liver enzymes, lipid profile and other biochemical markers were measured in the collected samples by using standard methods. All statistical analys

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Turki, Wasan Qasim. "The Effect of Cigarette Smoking on Serum Liver Enzymes in Baghdad." Ibn AL- Haitham Journal For Pure and Applied Sciences 2021 (June 1, 2021): 52–56. http://dx.doi.org/10.30526/2021.ihicpas.2651.

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Smoking is the most noticeably horrible human conduct; it is rehearsed by individuals dependent on nicotine numerous hurtful sicknesses, for example, cancer and liver disorder are brought about by smoking cigarettes. So this study aimed to study some of the liver function represented by the enzymes aspartate aminotransferase (AST or GOT) and alanine aminotransferase (ALT or GPT) in smokers and non-smokers for 50 persons in a group consists of 25 smokers and 25 non-smokers of different ages and to study the effectiveness of cigarette smoking on liver enzymes by checking the secretion of (AST) (

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Salama, Khaled M., Ola M. Ibrahim, Ahmed M. Kaddah, Samia Boseila, Leila Abu Ismail, and May M. Abdel Hamid. "Liver Enzymes in Children with beta-Thalassemia Major: Correlation with Iron Overload and Viral Hepatitis." Open Access Macedonian Journal of Medical Sciences 3, no. 2 (2015): 287–92. http://dx.doi.org/10.3889/oamjms.2015.059.

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BACKGROUND: Beta Thalassemia is the most common chronic hemolytic anemia in Egypt (85.1%) with an estimated carrier rate of 9-10.2%. Injury to the liver, whether acute or chronic, eventually results in an increase in serum concentrations of Alanine transaminase (ALT) and Aspartate transaminase (AST).AIM: Evaluating the potentiating effect of iron overload & viral hepatitis infection on the liver enzymes.PATIENTS AND METHODS: Eighty (80) thalassemia major patients were studied with respect to liver enzymes, ferritin, transferrin saturation, HBsAg, anti-HCV antibody and HCV-PCR for anti-HCV

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Aller, Rocio, David Pacheco, Olatz Izaola, David Primo, and Daniel A. de Luis. "Effect on Liver Enzymes of Biliopancreatic Diversion: 4 Years of Follow-Up." Annals of Nutrition and Metabolism 66, no. 2-3 (2015): 132–36. http://dx.doi.org/10.1159/000375506.

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Background: Elevated serum aminotransferase levels are commonly associated with obesity and with a progression to chronic liver disease. Bariatric surgery is the most effective strategy to achieve weight loss. Methods: We conducted the present study with the aim of evaluating the influence of biliopancreatic diversion (BPD) on liver enzymes levels during 4 years in morbid obese patients with normal aminotransferase (n = 65) and in morbid obese patients with high aminotransferase basal levels (n = 50). Results: A decrease in alanine aminotransferase and aspartate aminotransferase activities was

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Musa, A. H., I. A. Abdulmajid, B. A. Haruna, and J. Ismaila. "Effect of Chronic Consumption of Smokeless Tobacco (Snuff) on Liver Enzymes of Males in Maiduguri, Northeast Nigeria." Sokoto Journal of Medical Laboratory Science 7, no. 1 (2022): 107–14. http://dx.doi.org/10.4314/sokjmls.v7i1.14.

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Smokeless tobacco snuff consumption is as dangerous as cigarette smoking. It is now considered a significant source of morbidity and mortality owing to the effect of the numerous chemical constituents. Thus, this study was designed to investigate the effect of chronic consumption of Smokeless Tobacco (Snuff) on Liver Enzymes of males in Maiduguri and its environs, Northeast Nigeria. In this study we recruited 109 individuals who were smokeless tobacco snuffers and 97 healthy controls. It was a prospective case control study performed in adult males (30-50 years and 23 – 48 years for case and c

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Pandeya, Arun, Naveen Kumar Shreevastva, Arun Dhungana, Anup Pandeya, and Binita Pradhan. "Evaluation of Liver Enzymes and calculation of AST to ALT ratio in patients with acute viral hepatitis." Europasian Journal of Medical Sciences 3, no. 2 (2021): 83–86. http://dx.doi.org/10.46405/ejms.v3i2.255.

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Background: Acute viral hepatitis is a common liver-associated abnormality encountered in clinical practice. The number of biochemical parameters is estimated to detect a hepatic abnormality, which can measure the severity and types of damage to hepatocytes, among which liver enzymes and bilirubin levels are assessed routinely which are raised in acute viral hepatitis.Objective: This study aims to assess the liver enzymes, such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, and calculation of AST to ALT ratio in acute viral hepatitis and to compare these parame

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Panteghini, M., F. Pagani, and C. Cuccia. "Effects of therapeutic coronary reperfusion on aspartate aminotransferase isoenzymes in sera of patients with acute myocardial infarction." Clinical Chemistry 35, no. 6 (1989): 909–12. http://dx.doi.org/10.1093/clinchem/35.6.909.

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Abstract We examined the kinetics of the catalytic activities of aspartate aminotransferase (AST, EC 2.6.1.1) isoenzymes in serum of 28 patients with myocardial infarction who were to receive either intracoronary urokinase--reperfusion angiographically proved--or conventional therapy (control group). Cytosolic (soluble) AST (s-AST) activity in serum increased rapidly immediately after recanalization, reaching a maximum 12 h after the onset of infarction. In the control group, this peak was reached 28 h after the onset (P less than 0.001). Peak s-AST activity was similar in the two groups. Peak

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Mamta, Kumar Vikas, and Kumar Alok. "Study of Changes in Hepatic Enzymes after Laparoscopic Surgery." International Journal of Pharmaceutical and Clinical Research 16, no. 1 (2024): 825–28. https://doi.org/10.5281/zenodo.11100601.

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<strong>Background and Objectives:</strong> The purpose of this study was to investigate the effect of laparoscopic surgeries on liver function in humans and the possible mechanisms behind such effect. The modern era has witnessed a vast change in the field of medicine. With the advances in science and technology and better access to a variety of services. The purpose of this study was to investigate the effect of laparoscopic surgeries on liver function in humans and the possible mechanisms behind such effect. To evaluate the effects of laparoscopic surgery on liver enzymes Aspartate Ami

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Nikniaz, Leila, Masood Shirmohammadi, Jafar Sadegh Tabrizi, Homayoun Sadeghi Bazargani, and Mostafa Farahbakhsh. "Positive Association Between Serum 25-Hydroxy-Vitamin D and Liver Enzymes Levels in Healthy Individuals: A Population-Based Study from Iran." International Journal for Vitamin and Nutrition Research 86, no. 3-4 (2016): 127–32. http://dx.doi.org/10.1024/0300-9831/a000417.

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Objective: The relationship between serum 25-hydroxy-vitamin D and within normal range liver enzymes in a population-based study in the northwest of Iran was investigated. Method: This cross-sectional study was comprised of 700 apparently healthy Iranian adults (287 men & 413 women) who participated in the major lifestyle promotion project (LPP) conducted in East Azarbaijan-Iran in 2015. The ultraviolet method and chemiluminescent immunoassay technology were respectively used for determination of the serum levels of liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransfera

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Ibraheem, Aseel Khalil, Heyam A. Hashim, and Shaymaa Saadi Abbood. "Study of The Effect of Boswellia Leaf Extract on The Activity of Cardiac Enzymes (ALP, AST, ALT, LDH) Using Spectroscopic Methods." Nabatia 12, no. 1 (2024): 1–19. http://dx.doi.org/10.21070/nabatia.v12i1.1635.

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This study investigates the impact of Boswellia carterii leaf extracts on serum enzyme activity in myocardial infarction (MI) patients. Employing a comparative analysis between 60 healthy individuals and 40 cardiac patients, we measured the serum activity of ALP, AST, ALT, and LDH enzymes. Our findings reveal elevated enzyme activity in MI patients. We explored the inhibitory effects of aqueous, alcoholic, and ethyl acetate extracts of Boswellia carterii on these enzymes, demonstrating non-competitive inhibition. The inhibition ratio of ALT, ALP, and AST post-treatment was quantitatively asses

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Abbas A. Mohammed, Hamid H. Mohammed, Mustafa T, Zahraa abed hussain, and Zainab N. Mageed. "Synthesis , Characterization and Study the Effect of Benzothiazol-pyrazole Derivatives on the Activity of AST, ALT Enzymes." Journal of Kufa for Chemical Sciences 2, no. 9 (2023): 242–63. http://dx.doi.org/10.36329/jkcm/2022/v2.i9.13297.

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This work includes synthesis some of 2-(4,5-dihydro-1H-pyrazol-1-yl)-1,3-benzothiazole derivatives which synthesized from 2-hydrazino-1,3-benzothiazole with dicarbonyl compounds. The prepared compounds were characterized by FT-IR, 1HNMR and also studied the physical properties. The effect of the biological activity for these compounds were studied on the activity of AST and ALT enzymes in human serum of myocardial infarction patients. The studies show the compounds (A2 and A5) caused inhibition while the compound (A3 and A4) caused activation for the activity for AST and ALT enzymes.

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B. Abdallah, Omar, Younis MYG, Jamal A. Alammari, and Fatima Abdelmalek. "EVALUATION OF HEPATIC ENZYMES IN LIBYAN CHRONIC KIDNEY DISEASE PATIENTS: NEED FOR LOWER STANDARD "NORMAL" RANGE." EPH - International Journal of Applied Science 2, no. 4 (2016): 23–29. http://dx.doi.org/10.53555/eijas.v2i4.137.

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Chronic Kidney disease (CKD) patients on hemodialysis treatment are at higher risk of hepatitis C infection and they showed lower serum levels of aminotransferases than general population. These hepatic enzymes aid in the diagnosis, monitoring, and treatment of hepatic diseases. The present study aimed to estimate the changes in serum ALT, AST and ALP levels in both predialysis (PreHD-CKD) and hemodialysis (HD-CKD) patients in comparison to normal controls and to find out the association between hepatic enzyme changes and estimated Glomerular Filtration Rate (eGFR). The present study included

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Maheswara Rao, Chattu. "Hepatoprotective effect of methanolic extracts of Phyllanthus virgatus against carbon tetrachloride-induced liver injury in rats." Research in Pharmacy and Health Sciences 2, no. 1 (2016): 1–7. http://dx.doi.org/10.32463/rphs.2016.v02i01.01.

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In this study, the methanolic extract of Phyllanthus virgatus was evaluated against carbon tetrachloride (CCl4) induced hepatotoxicity in rats. The results of this study indicated that Phyllanthus virgatus exhibited moderate protective effect at a dose of 100-200 mg/kg by lowering serum level of liver enzymes such as alanine amino transferees (ALT), glutamate pyruvate transaminases (SGPT), aspartate aminotransferase (AST), glutamate oxaloacetate transaminases (SGOT), and total protein to a significant extent. Further, no significant effects were seen on blood serum level at a dose of 100-200 m

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Mahdavi Asiabar, Mojtaba, Mokhtar Nasiri Farsani, and Nematollah Gheibi. "Assessment of Propolis Supplementation on Serum Concentrations of Liver Enzymes in Endurance Athletes with Four Weeks Aerobic Training." Journal of Qazvin University of Medical Sciences 25, no. 1 (2021): 25–30. http://dx.doi.org/10.32598/jqums.25.1.7.

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Background: Aerobic and intense exercises with an increase in free radicals cause damages at the cellular level, heart disease, cancer, and the development of aging processes, which one of its symptoms is increased serum concentrations of liver enzymes. Objective: The purpose of this study was to investigate the concurrent effect of four weeks of aerobic training and propolis supplementation on the activity of liver enzymes, including ALT, AST, and SOD in endurance athletes. Methods: Thirty-two male athletes (age: 21±1.4 years) in track and field were randomly divided into three groups: exerci

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Zhu, Yuling, Huili Zhang, Yiming Sun, et al. "Serum Enzyme Profiles Differentiate Five Types of Muscular Dystrophy." Disease Markers 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/543282.

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Background.Differentiation among types of muscular dystrophy (MD) has remained challenging. In this retrospective study, we sought to develop a methodology for differentiation of MD types using analysis of serum enzyme profiles.Methods.The serum levels of enzymes from 232 patients, including 120 with DMD, 36 with BMD, 36 with FSHD, 46 with LGMD, and 11 with EDMD, were evaluated.Results.The characteristic profiles of serum enzymes facilitated differentiation of these five types of MD. DMD was characterized by simultaneous elevation of ALT, AST, LDH, and ALP; BMD and LGMD were characterized by e

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Jwarchan, Bishnu, Subita Lalchan, Anil Dhakal, and Ramesh R. Acharya. "Comparison of liver enzymes and sonological grading in nonalcoholic fatty liver." Asian Journal of Medical Sciences 11, no. 2 (2020): 42–45. http://dx.doi.org/10.3126/ajms.v11i2.27203.

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Background: Nonalcoholic fatty liver disease (NAFLD) is the leading cause of diffuse liver disease with a global prevalence of 25.24% and progresses to fibrosis and nonalcoholic steatohepatitis (NASH). Diagnosing NAFLD requires demonstration of increased liver fat and ultrasound imaging is widely used for screening. Specific blood tests to diagnose NAFLD and NASH are not yet available and alanine transaminase (ALT) has been used as a marker in population based studies. Aims and Objective: This study was aimed to compare the liver enzymes and sonological grading in NAFLD. Materials

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Nnodim, Johnkennedy, Emejulu Adamma, and Elendu Humphrey Ndubueze. "Evaluation of Serum Hepatocellular Enzymes in Nigerian with Goitre." Asian Journal of Medical Sciences 2, no. 2 (2011): 79–81. http://dx.doi.org/10.3126/ajms.v2i2.3870.

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Objective: The determination of serum gammaglutamyl transferase (GGT),alkaline phosphatase(ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in patient with goitre in Owerri, Imo state Nigeria were investigated.Material & Methods: Thirty confirmed patients with goitre age 50 to 70years with the following thyroid index (Total T4 > 140.65±7.28nmol/l , Total T3 > 2.43±0.96nmol/l, Free T4 < 50.24±9.11nmol/l and TSH > 4.12±1.00nmol/l) were selected for the study. Thirty normal subjects free from goiter age 50 to 70 years were used as control. Patients with co

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Johnkennedy Nnodim, Emejulu Adamma, and Elendu Humphrey Ndubueze. "Evaluation of Serum Hepatocellular Enzymes in Nigerian with Goitre." Asian Journal of Medical Sciences 2, no. 2 (2011): 79–81. https://doi.org/10.71152/ajms.v2i2.3238.

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Objective: The determination of serum gammaglutamyl transferase (GGT),alkaline phosphatase(ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in patient with goitre in Owerri, Imo state Nigeria were investigated.Material & Methods: Thirty confirmed patients with goitre age 50 to 70years with the following thyroid index (Total T4 > 140.65±7.28nmol/l , Total T3 > 2.43±0.96nmol/l, Free T4 < 50.24±9.11nmol/l and TSH > 4.12±1.00nmol/l) were selected for the study. Thirty normal subjects free from goiter age 50 to 70 years were used as control. Patients with co

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Mustafa Ahmad Chabbar, Hamid Suleman, Youssef Zreik, Mustafa Ahmad Chabbar, Hamid Suleman, Youssef Zreik. "The prevalence of hepatitis C virus infection in patients with lichen planus: Case- Control Study: انتشار الخمج بفيروس التهاب الكبد ج عند مرضى الحزاز المسطح: دراسة حالة – شاهد". Journal of medical and pharmaceutical sciences 6, № 1 (2022): 18–27. http://dx.doi.org/10.26389/ajsrp.d180821.

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Background: Lichen planus (LP) is an idiopathic inflammatory disease of the skin and mucous membranes. It has been reported to be associated with diseases such as hepatitis C virus infection. However, this association vary from one geographic area to another. Objective: The aim of this study is to assess the prevalence of hepatitis C virus infection and liver enzymes abnormalities among patients with lichen planus compared to controls. Materials and Methods: This case- control study included 204 participants (102 with L.P. and 102 controls) from the dermatology clinic at Tishreen University Ho

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Mahdavi, Atena, Amirmansour Alavi Naeini, Mohammadreza Najafi, Mohammadreza Maracy, and Mohammadreza Aghaye Ghazvini. "Effect of levetiracetam drug on antioxidant and liver enzymes in epileptic patients: case-control study." African Health Sciences 20, no. 2 (2020): 984–90. http://dx.doi.org/10.4314/ahs.v20i2.55.

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Background: There is a limited amount of data regarding levetiracetam (LEV), an antiepileptic drug. Objective: This study was conducted to assess the effect of LEV on antioxidant status and liver enzymes. Method: In this case-control study, 33 epileptic patients under treatment with LEV for at least 6 months were compared with 35 healthy subjects. We measured serum total antioxidant capacity (TAC), salivary superoxide dismutase (SOD), alanine aminoteransferase (ALT), and aspartate aminoteransferase (AST) levels in both groups. Dietary intakes were collected using a Food Frequency Q

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Masoudkabir, Farzad, Shahrokh Karbalai, Ali Vasheghani-Farahani, et al. "The Association of Liver Transaminase Activity With Presence and Severity of Premature Coronary Artery Disease." Angiology 62, no. 8 (2011): 614–19. http://dx.doi.org/10.1177/0003319711405312.

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There is growing clinical interest in liver transaminases as novel biomarkers of cardiovascular risk. We investigated the possible association of serum liver transaminase activity with the presence and angiographic severity of premature coronary artery disease (CAD). A cross-sectional study was conducted on 187 younger patients (females <55 years and males <45 years) who underwent coronary angiography and had serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and high-sensitivity C-reactive protein (hsCRP) measured. Evaluation of coronary stenosis was by Gensini scor

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Adeyemi, OS, and MA Akanji. "Biochemical changes in the kidney and liver of rats following administration of ethanolic extract of Psidium guajava leaves." Human & Experimental Toxicology 30, no. 9 (2010): 1266–74. http://dx.doi.org/10.1177/0960327110388534.

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Furtherance to a previous report on the anti-trypanosomal properties of Psidium guajava aqueous leaf extract in rats experimentally infected with Trypanosoma brucei brucei, we have evaluated the effects of the daily intraperitoneal administration of P. guajava leaf extract to rats on the activities of alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and acid phosphatase (ACP) in the kidney, liver and serum. The results obtained revealed that the administration of the extract produced significant increase in the serum activities of AST, ALT, ALP and A

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Whitfield, John B., Gu Zhu, John E. Nestler, Andrew C. Heath та Nicholas G. Martin. "Genetic Covariation between Serum γ-Glutamyltransferase Activity and Cardiovascular Risk Factors". Clinical Chemistry 48, № 9 (2002): 1426–31. http://dx.doi.org/10.1093/clinchem/48.9.1426.

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Abstract Background: Several studies have shown that variation in serum γ-glutamyltransferase (GGT) in the population is associated with risk of death or development of cardiovascular disease, type 2 diabetes, stroke, or hypertension. This association is only partly explained by associations between GGT and recognized risk factors. Our aim was to estimate the relative importance of genetic and environmental sources of variation in GGT as well as genetic and environmental sources of covariation between GGT and other liver enzymes and markers of cardiovascular risk in adult twin pairs. Methods:

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R. Tawfeeq, Hiba. "Assessment of Liver Enzymes Activity in Patients with Rheumatoid Arthritis in Nineveh province." Tikrit Journal of Pharmaceutical Sciences 8, no. 2 (2023): 284–90. http://dx.doi.org/10.25130/tjphs.2012.8.2.18.284.290.

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Aim of the study: to determine the effect of Rheumatoid Arthritis(RA) on liver enzymes level. Methods: 75 subjects were enrolled in this study (40 patients with Rheumatoid arthritis (RA) and 35 healthy subjects as control group), at Mosul city, Northern of Iraq, aged 20-70 years. The biochemical parameters measured were some of liver function tests which include measurement of the liver enzymes activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT). Results: There was a significant increase in liver enzymes

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