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Journal articles on the topic 'Serum nitric oxide'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Duke, Trevor, Mike South, and Alastair Stewart. "Altered activation of the L-arginine nitric oxide pathway during and after cardiopulmonary bypass." Perfusion 12, no. 6 (1997): 405–10. http://dx.doi.org/10.1177/026765919701200609.

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The serum concentrations of nitrogen oxides, the stable metabolites of nitric oxide, were measured in 61 children during and after cardiopulmonary bypass (CPB) for surgery of congenital heart disease. Overall, there was a small reduction in serum nitrogen oxide concentrations during CPB, from a median of 27.5 (interquartile range 16.6-55.7) to 26.4 (15.3-40.6) μmol/l, followed by an increase in the following 24 h to 33.1 (21.3-46.7) μmol/l. The largest postoperative increases in nitrogen oxides occurred in children who developed renal impairment, or were treated with nitrovasodilators. There w

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VALVINI, E. M., and J. D. YOUNG. "Serum nitrogen oxides during nitric oxide inhalation." British Journal of Anaesthesia 74, no. 3 (1995): 338–39. http://dx.doi.org/10.1093/bja/74.3.338.

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3

Afrasyap, Lale, and Guler Ozturk. "NO Level and Endothelial NO Synthase Gene Polymorphism (Glu298Asp) in the Patients with Coronary Artery Disease from the Turkish Population." Acta Biochimica et Biophysica Sinica 36, no. 10 (2004): 661–66. http://dx.doi.org/10.1093/abbs/36.10.661.

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Abstract Nitric oxide is synthesized from L-arginine by endothelial nitric oxide synthase encoded by eNOS gene. This study was performed to investigate the relationship between the serum nitric oxide level and eNOS gene polymorphism in the Turkish population with angiographically diagnosed coronary artery disease (63.47 ± 9.10 years old, n=250) and control subjects without any history and/or risk factors of coronary artery disease (60.71 ± 9.14 years old, n=150). Griess assay and PCR-RFLP analysis were used to measure the serum nitric oxide metabolites and genotypes, respectively. It was found

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Kadam, Charushila Y., and Subodhini A. Abhang. "Effect of chemotherapy on serum nitric oxide levels in advanced stage breast cancer patients." International Journal of Research in Medical Sciences 8, no. 1 (2019): 189. http://dx.doi.org/10.18203/2320-6012.ijrms20195905.

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Background: The role of nitric oxide is still unclear in advanced breast cancer patients undergoing adjuvant chemotherapy. This study was undertaken to investigate the effect of chemotherapy on serum nitric oxide levels in advanced stage breast cancer patients.Methods: In this observational study, clinically and histopathologically proven sixty female patients with advanced stage breast cancer were included. According to Tumor-Node-Metastasis (TNM) classification, patients were further grouped as stage III and stage IV. Thirty healthy and age-matched female controls were selected for compariso

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Yadav, Bhagyashri, and Anjali Waghmode. "Role of Serum Nitric Oxide and Serum Uric Acid in Essential Hypertension." International Journal of Pharmaceutical and Clinical Research 15, no. 12 (2023): 1354–58. https://doi.org/10.5281/zenodo.11201569.

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<strong>Background:</strong> Essential Hypertension (EHT) affects 25% of the world’s population and is a major cause of stroke, congestive heart failure, end stage renal disease and myocardial infarction. The routine evaluation of essential hypertensive patient should include complete hemogram, microscopic urinalysis, albumin excretion, serum creatinine, blood urea, serum sodium, potassium, Fasting blood glucose levels and lipid profile. Uric Acid play pathogenic role in hypertension (HTN) mediated by several mechanisms and L-arginine nitric oxide pathway has an important role in hy

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Qurbani, Septiana Nur, Lelani Reniarti, and Alex Chairulfatah. "Serum ferritin, serum nitric oxide, and cognitive function in pediatric thalassemia major." Paediatrica Indonesiana 57, no. 3 (2017): 149. http://dx.doi.org/10.14238/pi57.3.2017.149-53.

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Background Hemolysis and repeated blood transfusions in children with thalassemia major cause iron overload in various organs, including the brain, and may lead to neurodegeneration. Hemolysis also causes decreased levels of nitric oxide, which serves as a volume transmitter and slow dynamic modulation, leading to cognitive impairment.Objective To assess for correlations between serum ferritin as well as nitric oxide levels and cognitive function in children with thalassemia major. Methods This analytical study with cross-sectional design on 40 hemosiderotic thalassemia major patients aged 6−1

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Mackenzie, I. M., A. Ekangaki, J. D. Young, and C. S. Garrard. "Effect of renal function on serum nitrogen oxide concentrations." Clinical Chemistry 42, no. 3 (1996): 440–44. http://dx.doi.org/10.1093/clinchem/42.3.440.

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Abstract Nitric oxide is too short-lived to measure in vivo, but its production can be estimated by measuring its stable oxidation products, nitrites and nitrates, in serum. Renal elimination of these ions has been demonstrated, but the effect of renal function on their concentrations in serum is currently unknown. We evaluated serum and urine nitrates + nitrites as serum nitrogen oxides (sNOx), nitrogen oxide (NOx) clearance, and creatinine clearance in 71 patients on the Intensive Therapy Unit. The correlation between sNOx and plasma creatinine was strong and highly significant (P &lt;0.

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Sasirekha, G. "Influence of endothelial nitric oxide synthase gene intron 4 VNTR polymorphism on serum nitric oxide level among healthy south-Indian population." MedPulse International Journal of Biochemistry 19, no. 2 (2021): 16–21. http://dx.doi.org/10.26611/10021922.

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Background: Nitric oxide (endothelium derived relaxing factor) is synthesized from L-arginine by nitric oxide synthases. Endothelial NOS is responsible for most of the nitric oxide produced under physiological conditions. Acting via cGMP NO cause smooth muscle relaxation, prevents platelet aggregation and acts as an anti-inflammatory agent thereby playing a vital role in regulating vascular tone. Various studies have postulated the role of Nitricoxide in vascular disorders like hypertension and atherosclerosis. This study is aimed to find out the influence of endothelial nitric oxide synthase

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Chen, Yi-Ming, Huashuai Li, Yen-Shuo Chiu, Chi-Chang Huang, and Wen-Chyuan Chen. "Supplementation of L-Arginine, L-Glutamine, Vitamin C, Vitamin E, Folic Acid, and Green Tea Extract Enhances Serum Nitric Oxide Content and Antifatigue Activity in Mice." Evidence-Based Complementary and Alternative Medicine 2020 (April 11, 2020): 1–10. http://dx.doi.org/10.1155/2020/8312647.

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It has been reported that abundant nitric oxide content in endothelial cells can increase exercise performance. The purpose of this study was to evaluate the potential beneficial effects of a combined extract comprising L-arginine, L-glutamine, vitamin C, vitamin E, folic acid, and green tea extract (LVFG) on nitric oxide content to decrease exercise fatigue. Male ICR (Institute of Cancer Research) mice were randomly divided into 4 groups and orally administered LVFG for 4 weeks. The 4-week LVFG supplementation significantly increased serum nitric oxide content in the LVFG-1X and LVFG-2X group

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Runtunuwu, Ari L., Jeanette I. Ch Manoppo, Dasril Daud, Irawan Yusuf, and Idham Jaya Ganda. "Prognostic value of nitric oxide in pediatric septic shock." Paediatrica Indonesiana 56, no. 4 (2016): 211. http://dx.doi.org/10.14238/pi56.4.2016.211-4.

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Background Nitric oxide (NO) play a key role in the pathogenesis of septic shock. Nitrit oxide metabolite is reported as a good predictor for shock although its role as mortality predictor in sepsis still controversial.Objective To assess the serum nitric oxide (NO) levels and outcomes in pediatric patients with septic shock.Methods We conducted a prospective cohort study from January 2013 to April 2014 in Pediatric Intensive Care Unit (PICU) Prof. Dr. R. D. Kandou Hospital, Manado. Subjects were patients aged 1 month-12 years diagnosed with septic shock. We measured initial serum NO and obser

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Narawade, Sharwari Y., Charushila Y. Kadam, and Subodhini A. Abhang. "Differential Status of Serum Arginine, Arginase and Nitric Oxide in Patients of Chronic and Advanced Stage Kidney Disease Undergoing Hemodialysis." Biomedical and Pharmacology Journal 17, no. 1 (2024): 393–400. http://dx.doi.org/10.13005/bpj/2866.

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Background: Chronic kidney disease (CKD) is characterized by deterioration of endothelial function which is associated with reduced availability of nitric oxide. The objective of the study was to assess the differential status of the serum levels of arginine, arginase, NO, urea and creatinine in CKD patients not on hemodialysis and in end stage renal disease (ESRD) patients receiving hemodialysis. Material and Methods: In this case control study, clinically diagnosed 30 CKD patients (group I), 30 ESRD patients before hemodialysis (Group II), 30 patients with ESRD after first hemodialysis (grou

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Akdeniz, N., M. Esrefoglu, MS Keles, A. Karakuzu, and M. Atasoy. "Serum Interleukin-2, Interleukin-6, Tumour Necrosis Factor-Alpha and Nitric Oxide Levels in Patients With Behçet’s Disease." Annals of the Academy of Medicine, Singapore 33, no. 5 (2004): 596–99. http://dx.doi.org/10.47102/annals-acadmedsg.v33n5p596.

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Introduction: Behçet’s disease (BD) is a chronic systemic disorder characterised by oral and genital ulcerative lesions, ocular and cutaneous manifestations. Cytokines are the major mediators of immunologic and inflammatory reactions. Nitric oxide is reactive nitrogen intermediate which plays a key role in pathogenesis of many inflammatory and autoimmune skin diseases. The study was conducted to determine serum interleukin-2 (IL-2), interleukin-6 (IL-6), tumour necrosis factor (TNF)-alpha and nitric oxide levels in relation to the pathogenesis of Behçet’s disease. Materials and Methods: Serum

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Hegde, Nidarsh D., Suchetha Kumari, Mithra N. Hegde, and Shilpa Shetty. "ROLE OF NITRIC OXIDE AND ARGINASE IN THE PATHOGENESIS OF ORAL CANCER." Journal of Health and Allied Sciences NU 02, no. 02 (2012): 14–17. http://dx.doi.org/10.1055/s-0040-1703564.

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AbstractThe aim of the present study is to evaluate the status of serum nitric oxide and arginase activity in oral cancerous condition. The study consisted of 80 individuals. The subjects were divided into normal individuals and individuals with oral cancer. Blood sample was collected from each subject and serum separated. Nitric oxide concentration was measured as total nitrates and nitrites by the Griess reaction method and arginase activity was estimated by diacetylmonoxime method.The results of this study showed significantly increased levels of nitric oxide and arginase activity in oral c

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Mohajeri, Mahsa, and Arrigo F. G. Cicero. "Adherence to the Mediterranean Diet Association with Serum Levels of Nitric Oxide, Prostacyclin, and Thromboxane B2 among Prinzmetal Angina Patients and Healthy Persons." Nutrients 15, no. 3 (2023): 738. http://dx.doi.org/10.3390/nu15030738.

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This study aimed to assess the association between adherence to the Mediterranean diet with serum Nitric oxide, Prostacyclin, and Thromboxane B2 among Prinzmetal angina patients and healthy persons. This case-control study was conducted among 100 Prinzmetal angina patients and 100 healthy persons referred to the Ardabil Imam Khomeini hospital between 2021 and 2022. Blood samples were obtained from all study participants for measurement of serum Nitric oxide, Prostacyclin, and Thromboxane B2. To calculate adherence to the Mediterranean diet, the ten-item screener was used. The serum Nitric oxid

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Stechmiller, Joyce K., Bobbi Langkamp-Henken, Beverly Childress, et al. "Arginine Supplementation Does Not Enhance Serum Nitric Oxide Levels in Elderly Nursing Home Residents With Pressure Ulcers." Biological Research For Nursing 6, no. 4 (2005): 289–99. http://dx.doi.org/10.1177/1099800405274732.

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The purpose of this study was to determine whether arginine supplementation enhances in vitro (neutrophil burst and mitogen-induced lymphocyte proliferation) and in vivo (delayed-type hypersensitivity [DTH] and serum nitric oxide) measures of immune function in nursing home elders with pressure ulcers. Twenty-six elders, 65 years of age or older, with one or more pressure ulcers, were randomized to receive 8.5 g of arginine or an isonitrogenous supplement for 4 weeks. Immune function studies and serum arginine, ornithine, citrulline, and nitric oxide were measured at baseline, 4 weeks postsupp

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El Dayem, Soha M., Ahmed A. Battah, Abo El Maged El Bohy, Solaf Ahmed, Mona Hamed, and Safa Nabil Abd El Fattah. "Nitric Oxide Gene Polymorphism is a Risk Factor for Diabetic Nephropathy and Atherosclerosis in Type 1 Diabetic Patients." Open Access Macedonian Journal of Medical Sciences 7, no. 19 (2019): 3132–38. http://dx.doi.org/10.3889/oamjms.2019.831.

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AIM: To assess the risk factor for diabetic atherosclerosis nephropathy and diabetic nephropathy in type 1 diabetic patients. PATIENTS AND METHODS: Thirty healthy volunteers age and sex-matched and Sixty-five type 1 diabetic patient were in rolled in the study. The mean age of patients was 17.99 ± 2.59 years, mean age of onset of diabetes was 7.00 ± 3.28 years, mean duration of diabetes was 10.91 ± 3.54 years. Glycosylated sex-matched (HbA1c) was assessed in blood samples, serum lipid profile was determined, and serum level of oxidised low-density lipoprotein (OxLDL), and nitric oxide wa

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Gur, Tugba Gur, Gulsen Enterili, Necip Pirincci, et al. "Investigation of Serum Enzyme Activity of Nitric Oxide (NO), Arylesterase (ARE) and Paraoxanase (PON) in Renal Tumors." Medical Science and Discovery 4, no. 3 (2017): 23–26. https://doi.org/10.36472/msd.v4i3.184.

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Objective: Reactive oxygen species (ROS) and antioxidant capacity have been implicated in the pathogenesis of various diseases, and cancers. Oxidative stress can cause tumor angiogenesis and may be carcinogenic. However, the relationship between antioxidant capacity and various cancers has been researched in several clinical trials. Materials and Methods: In this study, we aimed to identify serum Nitric Oxide (NO), Arylesterase (ARE) and paraoxonase (PON) activities in patients with renal tumors. Serum ARE, PON and NO levels were measured by spectrophotometer. Results: Increased activity of se

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Ghasemi, Asghar, Saleh Zahediasl, Iraj Azimzadeh, and Fereidoun Azizi. "Increased serum nitric oxide metabolites in dysglycaemia." Annals of Human Biology 38, no. 5 (2011): 577–82. http://dx.doi.org/10.3109/03014460.2011.575384.

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Chandra, Ronald, Jose M. Mandei, Jeanette I. Ch Manoppo, Rocky Wilar, Ari L. Runtunuwu, and Phey Liana. "Serum nitric oxide and pediatric sepsis outcomes." Paediatrica Indonesiana 54, no. 4 (2014): 213. http://dx.doi.org/10.14238/pi54.4.2014.213-8.

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Background Sepsis is the complex pathophysiologic responsesof the host against systemic infection. Sepsis can cause severeconditions such as septic shock and multiple organ failure.Although we have a better understanding of the molecular basisof sepsis as well as aggressive therapy, the mortality rate remainshigh, between 20-80%. Nitric oxide (NO) is one of the mediatorsassociated with cardiovascular failure, apoptosis and organdysfunction in sepsis.Objective To evaluate for a possible correlation between NOlevels and outcomes in pediatric sepsis.Methods A prospective cohort study was conducte

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Al-Nimer, Marwan S. M., Majid M. Mahmood, and Saba Saadoon Khazaal. "Nitrostative stress status during seasonal and pdmH1N1 infection in Iraq." Journal of Infection in Developing Countries 5, no. 12 (2011): 863–67. http://dx.doi.org/10.3855/jidc.1505.

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Introduction: Influenza A virus infection is associated with oxidative and nitrosative stress. This study aimed to assess nitrosative stress in pandemic H1N1 (pdmH1N1) and seasonal influenza A infected patients. Methodology: The study included the following subjects: 20 patients infected with seasonal (negative one-step probe RT-PCR) influenza and 12 patients infected with pdmH1N1 (positive, one-step probe RT-PCR) influenza during the 2009 pandemic in Iraq. Twenty healthy subjects served as controls. Serum nitric oxide using Greiss reagent and peroxynitrite were used to assess nitrosative stre

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Żebrowska, Aleksandra, Dariusz Jastrzębski, Ewa Sadowska-Krępa, Marcin Sikora, and Camillo Di Giulio. "Comparison of the Effectiveness of High-Intensity Interval Training in Hypoxia and Normoxia in Healthy Male Volunteers: A Pilot Study." BioMed Research International 2019 (September 22, 2019): 1–10. http://dx.doi.org/10.1155/2019/7315714.

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Aims. The study investigated the effect of high-intensity interval training in hypoxia and normoxia on serum concentrations of proangiogenic factors, nitric oxide, and inflammatory responses in healthy male volunteers. Methods. Twelve physically active male subjects completed a high-intensity interval training (HIIT) in normoxia (NorTr) and in normobaric hypoxia (HypTr) (FiO2 = 15.2%). The effects of HIIT in hypoxia and normoxia on maximal oxygen uptake, hypoxia-inducible factor-1-alpha, vascular endothelial growth factor, nitric oxide, and cytokines were analyzed. Results. HIIT in hypoxia sig

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Giovannoni, G. "Cerebrospinal fluid and serum nitric oxide metabolites in patients with multiple sclerosis." Multiple Sclerosis Journal 4, no. 1 (1998): 27–30. http://dx.doi.org/10.1177/135245859800400107.

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Nitric oxide is hypothesised to play a role in the immunopathogenesis of multiple sclerosis. Raised cerebrospinal fluid and serum levels of the nitric oxide metabolites nitrate and nitrite have been described in patients with multiple sclerosis. Cerebrospinal fluid and serum nitrate and nitrite were measured in patients with multiple sclerosis, inflammatory and non-inflammatory neurological diseases, and correlated with the albumin quotient, an index of blood-brain-barrier dysfunction. Patients undergoing diagnostic lumbar and vene puncture were prospectively recruited, clinical data were obta

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Batool, Saba, Saima Noreen, Tooba Malik, Javaria Fatima, Bushra Shaheen, and Sheikh Maria Qammar. "Evaluation of Nitric Oxide Activity of Torilis Leptophyllain Indomethacin Induced Gastric Ulcer in Mice." Pakistan Armed Forces Medical Journal 73, no. 6 (2023): 1590–93. http://dx.doi.org/10.51253/pafmj.v73i6.6904.

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Objective: To evaluate the Nitric Oxide activity of Torilis leptophylla in Indomethacin-induced gastric ulcers in mice. Study Design: Laboratory-based experimental study Place and Duration of Study: Pharmacology Department, University of Health Sciences, Lahore Pakistan, from Jan to Dec2016. Methodology: Thirty-six adult healthy male BALB/C mice with a weight range of 25-35 g were equally divided into six groups and designated as Group-I (Control), Group-II (Positive Control), Groups III to V (Torilis leptophylla extract trial Groups) and Group-VI (Omeprazole). Gastric ulceration was induced b

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Jagtap, Vanita Ramesh, and Madhumati Jagdish Landage. "Study of lipid profile and nitric oxide in chronic smokers." International Journal of Clinical Biochemistry and Research 11, no. 2 (2024): 125–28. http://dx.doi.org/10.18231/j.ijcbr.2024.019.

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Cigarette smoking is associated with an increased risk of respiratory tract infections, chronic airway disease, and cardiovascular diseases, all of which may be modulated by endogenous nitric oxide. We have investigated whether cigarette smoking reduces the production of endogenous NO. Oxidative stress also alters the lipid profile in chronic smokers. With this view, we planned to assess vasodilators by determining the level of nitric oxide and lipid profile in chronic smokers. This study aims to: 1) determine the level of nitric oxide in chronic smokers. 2) estimate the level of lipid profile

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Wozniak, Lukasz, Wioletta Ratajczak-Wrona, Jan Borys, et al. "Levels of Biological Markers of Nitric Oxide in Serum of Patients with Mandible Fractures." Journal of Clinical Medicine 10, no. 13 (2021): 2832. http://dx.doi.org/10.3390/jcm10132832.

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Background: Nitric oxide is a small gaseous molecule with significant bioactivity. It has been observed that NO may have a dual role dependent on its production and concentrations in the bone microenvironment. The objective of the study was to assess the concentration of total nitric oxide malonyldialdehyde, nitrotyrosine, and asymmetric dimethylarginine in the serum of patients with mandibular fractures and to understand the relationship between these compounds, in order to expand the knowledge base of the role of nitric oxide and its activity indicators in the process of bone fracture healin

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Lesnaya, A. S., N. V. Semenova, M. A. Darenskaya, L. V. Rychkova, D. V. Balzhirova, and L. I. Kolesnikova. "Nitrosative stress in adolescents with exogenous constitutional obesity." Voprosy detskoj dietologii 21, no. 6 (2023): 85–90. http://dx.doi.org/10.20953/1727-5784-2023-6-85-90.

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Objective. To study the levels of nitric oxide, advanced oxidation protein products and total antioxidant activity in serum and plasma in adolescents with exogenous constitutional obesity. Patients and methods. The study group included 46 adolescents with class I exogenous constitutional obesity (24 girls and 22 boys). The control group included 43 adolescents with normal body weight (23 girls and 20 boys). The levels of nitric oxide, advanced oxidation protein products and total antioxidant activity in serum and plasma were determined by spectrophotometry. Results. There were no statistically

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Li, J., B. Shi, S. Yan, L. Jin, Y. Guo, and T. Li. "Effects of chitosan on nitric oxide production and inducible nitric oxide synthase activity and mRNA expression in weaned piglets." Czech Journal of Animal Science 60, No. 8 (2018): 359–66. http://dx.doi.org/10.17221/8405-cjas.

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The effects of chitosan on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) activity and gene expression in vivo or vitro were investigated in weaned piglets. In vivo, 180 weaned piglets were assigned to five dietary treatments with six replicates. The piglets were fed on a basal diet supplemented with 0 (control), 100, 500, 1000, and 2000 mg chitosan/kg feed, respectively. In vitro, the peripheral blood mononuclear cells (PBMCs) from a weaned piglet were cultured respectively with 0 (control), 40, 80, 160, and 320 &micro;g chitosan/ml medium. Results showed that ser

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Hussain, Sabah N. A., Mohammed N. Abdul-Hussain, and Qassim El-Dwairi. "Exhaled nitric oxide as a marker for serum nitric oxide concentration in acute endotoxemia." Journal of Critical Care 11, no. 4 (1996): 167–75. http://dx.doi.org/10.1016/s0883-9441(96)90027-1.

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Krasnoselskyi, Mykola V., Elena S. Pushkar, Larisa I. Simonova-Pushkar, and Mykhailo S. Myroshnychenko. "NITRIC OXIDE METABOLISM FEATURES UNDER CONDITIONS OF EXPERIMENTAL INFECTED RADIATION-INDUCED SKIN INJURIES DEVELOPMENT AND THEIR TREATMENT WITH PHOTODYNAMIC THERAPY." Wiadomości Lekarskie 73, no. 8 (2020): 1655–58. http://dx.doi.org/10.36740/wlek202008112.

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The aim: To follow-up nitric oxide content values in rat serum at the development of Staphylococcus aureus infected radiation skin injuries and their photodynamic therapy. Materials and methods: Eighty WAG male rats were studied in an experiment. Four groups were identified for evaluation. Group 1 included unaffected intact rats (n=20). Group 2 involved rats (n=20) with a modeled radiation-induced ulcer of the skin. The rats (n=20) with a modeled radiation-induced skin ulcer followed by infecting with Staphylococcus aureus were referred to group 3. Group 4 included rats (n=20) with Staphylococ

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Allman, K. G., A. P. Stoddart, M. M. Kennedy, and J. D. Young. "L-arginine augments nitric oxide production and mesenteric blood flow in ovine endotoxemia." American Journal of Physiology-Heart and Circulatory Physiology 271, no. 4 (1996): H1296—H1301. http://dx.doi.org/10.1152/ajpheart.1996.271.4.h1296.

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We studied the effects of administrating the nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), or the nitric oxide precursor, L-arginine, on hemodynamic variables and serum nitrate concentrations in an anesthetized ovine model of endotoxemia to assess the effects on regional visceral blood flow and to determine whether L-arginine availability limits nitric oxide production. Animals received Escherichia coli endotoxin (2 micrograms/kg) followed 2 h later by L-NAME (25 mg/kg), L-arginine (0.575 g/kg), or saline administered over 1 h followed by an infusion of the same d

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Korkotashvili, L. V., S. V. Romanova та S. A. Kolesov. "NITRIC OXIDE, ITS METABOLITES, AND GLUTATHIONE SYSTEM IN CHILDREN WITH CHRONIC VIRAL HEPATITIS В AND С". Annals of the Russian academy of medical sciences 68, № 10 (2013): 26–30. http://dx.doi.org/10.15690/vramn.v68i10.784.

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Aim. To detect changes in the concentration of nitric oxide and its metabolites – nitrites and nitrates in conjunction with the indices of the glutathione system in the children with chronic hepatitis В and С. Patients and methods. In the research took a part 76 patients (boys or girls) with chronic hepatitis В and С aged from 7 up to 16 years. Nitric oxide and its metabolites determined by method of V.A. Metel’skaya and N.G. Gumanova; level of reduced glutathione – the titrimetric analysis; activity of glutathione transferase – the method of spectrophotometry. Results. The content of nitric o

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Chen, Shuo, Lei Zhang, Ruonan Xu, et al. "BDKRB2 +9/−9 bp polymorphisms influence BDKRB2 expression levels and NO production in knee osteoarthritis." Experimental Biology and Medicine 242, no. 4 (2016): 422–28. http://dx.doi.org/10.1177/1535370215625471.

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The bradykinin B2 receptor (BDKRB2) plays a key role in the inflammation process of osteoarthritis. Nitric oxide has also long been considered to be a catabolic factor that contributes to inflammatory response and the osteoarthritis disease pathology. Several studies have reported that the BDKRB2 +9/−9 bp polymorphisms are associated with transcription of the receptor. However, the roles of BDKRB2 polymorphisms in inflammation in osteoarthritis remain unclear. This study enrolled 156 subjects with primary knee osteoarthritis and 58 healthy volunteers. BDKRB2 polymorphisms were genotyped, and t

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Asmaa Hamza Radeef. "Evaluation of nitric oxide and uric acid in patients with headache." GSC Advanced Research and Reviews 22, no. 2 (2025): 138–41. https://doi.org/10.30574/gscarr.2025.22.2.0058.

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Backgrounds: Headache, a painful sensation in the head or neck, can be categorized as primary, tension-type, and cluster headaches. Factors influencing nitric oxide levels, such the eNOS gene mutation and uric acid, may result in endothelial dysfunction. This study intends to evaluate these parameters. Objectives: Assess the factors that may affect the levels of nitric oxide, which is the main mediator of endothelial dysfunction. Material and Methods: The study includes 40 individuals who suffer from headaches and 40 healthy volunteers who are matched in terms of age and gender. eNOS enzyme co

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Rossokha, Z. I., L. Ye Fishchuk, V. I. Pokhylko, Yu I. Cherniavska, and N. G. Gorovenko. "PROGNOSTIC VALUE OF SERUM MAGNESIUM LEVEL AS A MARKER OF ENDOTHELIAL DYSFUNCTION IN PREMATURE BIRTH NEONATES." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 20, no. 3 (2020): 25–29. http://dx.doi.org/10.31718/2077-1096.20.3.25.

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Optimal magnesium supply during pregnancy and overcoming magnesium deficiency is essential due to its physiological role in many metabolic processes. Metabolic transformations with magnesium are necessary for the vitamin D activation, energy supply for homocysteine restoration, and regulation of nitric oxide synthesis. Magnesium deficiency increases the risk of premature birth, and the diffusion of magnesium to the fetus increases precisely from the second trimester of pregnancy, therefore, its deficiency can adversely affect neonatal adaptation. The aim of this work was to investigate the rel

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Cai, Yuli, Xiaochen Liu, Liang Ma, Wenxue Lv, Weiguo Wang, and Xingcai Zhang. "Jian-Pi-Yi-Shen drug-containing serum promotes proliferation and activity of mouse osteoblasts." Bioscience Journal 39 (June 9, 2023): e39083. http://dx.doi.org/10.14393/bj-v39n0a2023-64818.

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Jian-Pi-Yi-Shen (JPYS) decoction is a traditional Chinese herbal formula. The present study aimed to investigate the effect of JPYS drug-containing serum on the proliferation and activity of mouse osteoblasts. Sprague‒Dawley rats were fed JPYS decoction, calcium supplement, or normal saline for 6 weeks, and the serum was collected. Mouse osteoblasts were treated with JPYS drug-containing serum, calcium supplement serum, or blank control serum. Cell proliferation was assayed using thiazolyl blue tetrazolium bromide. Levels of alkaline phosphatase, nitric oxide, and nitric oxide synthase in the

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Ivanyushko – Nazarko, Natalya V., Оrysya О. Syzon, Svitlana V. Volbyn, Tetyana I. Rudnyk, and Marianna O. Dashko. "EXAMINING THE ROLE OF THE NITRIC OXID SYSTEM AS THE ESSENTIAL PATHOGENETIC LINK IN STEVENS-JOHNSON SYNDROME." Wiadomości Lekarskie 73, no. 9 (2020): 1900–1903. http://dx.doi.org/10.36740/wlek202009202.

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, , , , The aim: To determine a possible role of nitric oxide system as one of the pathogenesis links in Stevens-Johnson syndrome depending on the severity of disease progression. Material and methods: We examined 11 patients with Stevens-Johnson syndrome. The function of nitric oxide system (NO - NOS) in blood serum was examined. Results: During the study of nitric oxide system (NO-NOS) in patients with SJS, it was observed that NO2¯ level was increased by 1.53 times, NO3¯ level – by 3.33 times, activity of total NOS – by 5.78 times, constitutive (cNOS) – by 1.81 times and inducible (iNOS) –

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Preethi, Bangalore Lakshmangowda, Joseph Elizabeth, Delphine Silvia Wilma, and K.P.Suresh. "IMPACT OF EXERCISE ON ENDOTHELIUM-DEPENDENT VASODILATOR SERUM NITRIC OXIDE." International Journal of Basic and Applied Physiology 7, no. 1 (2018): 7–12. https://doi.org/10.5281/zenodo.4480444.

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Abstracts: The vascular endothelium produces a large number of vasodilator and vasoconstrictor compounds which regulate vascular tone. Nitric Oxide (NO) is recognised to be the most important and best characterised mediator; its intrinsic vasodilator function is commonly used as a surrogate index of endothelial function. Various studies have demonstrated that exercise training improves endothelium-dependent vasodilator function. Yoga is a group of physical, mental, and spiritual practices or disciplines which originated in ancient India. The poses and stretches are thought to have physical and

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Chełchowska, Magdalena, Jadwiga Ambroszkiewicz, Joanna Gajewska, et al. "Influence of Active Exposure to Tobacco Smoke on Nitric Oxide Status of Pregnant Women." International Journal of Environmental Research and Public Health 15, no. 12 (2018): 2719. http://dx.doi.org/10.3390/ijerph15122719.

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Smoking tobacco can impair proper vascular endothelial functioning. This is exhibited through reduced nitric oxide synthesis as well as activity due to accompanying oxidative stress. We examined the relationship between nitric oxide and markers of oxidative stress/antioxidant defense in serum of smoking and non-smoking pregnant women. Subjects included 99 healthy pregnant women, who were tested for nitric oxide (NO), endothelial (eNOS) and inducible (iNOS) nitric oxide synthase, total oxidant capacity (TOC), and total antioxidant capacity (TAC). NO, eNOS, and TAC serum concentrations were sign

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Kumar*, Ramesh, and Ritika Jain. "Studies on serum nitric oxide levels in subjects with high bilirubin value in comparison of normal healthy control subjects." International Journal of Bioassays 5, no. 03 (2016): 4870. http://dx.doi.org/10.21746/ijbio.2016.03.004.

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Bilirubin is excreted in bile and urine, and elevated levels may indicate certain diseases. Serum bilirubin are inversely related to risk of certain heart diseases. Since nitric oxide (NO) is produced by three types of Nitric Oxide Synthases (NOSs), rapid changes in stable oxidized metabolites (nitrite and nitrate) in the tissues and blood should be represented by the amount of stable forms in serum and may reflect changes in the body. Therefore, the aim of this study was to evaluate the correlation between nitric oxide (nitrite & nitrate) production and bilirubin levels in serum. The seru

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Parahita, Astra, Galuh Hardaningsih, and Anindita Soetadji. "The Association between Serum Malondialdehyde and Nitric Oxide Level of Children Living In Area of Chronic Pesticide Exposure." Diponegoro International Medical Journal 1, no. 1 (2020): 10–15. http://dx.doi.org/10.14710/dimj.v1i1.7897.

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Introduction: Chronic exposure of organophosphate pesticides is an oxidative stress that causes liver and aortic damage. Malondialdehyde (MDA) is a biological marker of oxidative damage to cell lipids membrane. The liver produces insulin growth factor-1 (IGF-1) which stimulates the enzyme nitric oxide synthase (eNOS) to produce vascular nitric oxide (NO). Children who are living in those area may be exposed to pesticide chronically. The aim of this study is to determine the relationship between serum MDA and NO level of children living in an area of chronic pesticide exposure.Method: Cross sec

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Ene, Corina Daniela, Mircea Penescu, Ilinca Nicolae, and Cristina Capusa. "The Role of the L-Arginine–Nitric Oxide Molecular Pathway in Autosomal Dominant Polycystic Kidney Disease." Journal of Personalized Medicine 14, no. 3 (2024): 299. http://dx.doi.org/10.3390/jpm14030299.

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Recently, arginine has been proven to play an important role in ADPKD physiopathology. Arginine auxotrophy in ADPKD induces cell hyperproliferation, blocking the normal differentiation of renal tube cells and causing cyst formation. We explored the L-arginine (Arg)–nitric oxide (NO) molecular pathway in ADPKD, a multisystemic arginine auxotrophe disease. We developed a prospective case–control study that included a group of 62 ADPKD subjects with an estimated filtration rate over 60 mL/min/1.73 mp, 26 subjects with chronic kidney disease with an eGFR > 60 mL/min/1.73 mp, and a group of 37 h

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Tukhvatullina, L. A., and R. G. Karimova. "INFLUENCE OF IMMUNOMODULATORS ON NON-SPECIFIC RESISTANCE AND PRODUCTION OF NITRIC OXIDE (II) IN THE ORGANISM OF CALVES." Scientific Notes Kazan Bauman State Academy of Veterinary Medicine 247, no. 3 (2021): 267–72. http://dx.doi.org/10.31588/2413-4201-1883-247-3-267-272.

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The article presents data on the dynamics of bactericidal activity of blood serum against St. aureus and E. coli, and the lysozyme activity of calf blood serum against Micrococcus lisodeicticus, as well as nitrate and nitrite anions when immunomodulators are administered. It has been established that administration of «Fosprenil» increases bactericidal and lysozyme activity of blood serum, whereas, Imunophane increases nonspecific resistance without affecting lysozyme activity. Nitric oxide (II) has been shown to be directly involved in the mechanism of non-specific immunity. At the same time,

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Kr. Singh, Jitendra, Pradeep Sharma, Sunil Kumar, Ajai Kumar, Kalbe Jawad, and Barkha Chauhan. "THE ROLE OF SERUM ESTROGEN AND NITRIC OXIDE (NO) IN POST-MENOPAUSAL KNEE OSTEOARTHRITIC FEMALE PATIENTS." International Journal of Advanced Research 11, no. 03 (2023): 464–67. http://dx.doi.org/10.21474/ijar01/16447.

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As we are all aware the hormone estrogen is the most essential sex hormone of the female. It plays significant roles in all phases of the life of females. Osteoarthritis is the most debilitating bone disorder commonly seen in females more than males. Out of all the joints knee joint is most commonly affected as it is the weight-bearing joint. So here in this study, the main objective is to know the role of serum estrogen and Nitric oxide levels in post-menopausal knee osteoarthritic female patients. The samples were collected and the chemiluminescence and ELISA method performed the tests. Cons

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Sasirekha, G. "Assessment of serum nitric oxide level in cigarette smoking." MedPulse International Journal of Biochemistry 18, no. 3 (2021): 43–47. http://dx.doi.org/10.26611/10021834.

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Background: Cigarette smoke has been implicated as a major risk factor in various diseases associated with endothelial dysfunction like essential hypertension, atherosclerosis and related cardiovascular dysfunction. Nitric oxide, an important second messanger plays a pivotal role in maintaining vasomotor tone and its level is also found to be altered in many chronic vascular disorders. The particulates in cigarette smoke is presumed to affect the production NO in vascular endothelium. Hence, it is proposed to study the effect of cigarette smoking in influencing Nitric oxide level. The study sa

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Hammad, Ayman, Ashraf Bakr, Gihan Fathy, Manal Fathy, and Rizk El Baz. "Serum Nitric Oxide in Post-Streptococcal Acute Glomerulonephritis." GEGET 2, no. 1 (2002): 33–36. http://dx.doi.org/10.21608/geget.2002.48370.

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BALIK, Ahmet A., S. Selçuk ATAMANALP, Mahmut BAŞOĞLU, M. İlhan YILDIRGAN, Cemal GÜNDOĞDU, and Ahmet KIZILTUNÇ. "Serum Nitric Oxide Levels in Experimental Intestinal Ischemia." Turkish Journal of Medical Sciences 27, no. 5 (1997): 393–95. http://dx.doi.org/10.55730/1300-0144.5016.

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VANDISSEL, J. "Serum nitric oxide and morbidity in postoperative patients." Lancet 344, no. 8926 (1994): 888–89. http://dx.doi.org/10.1016/s0140-6736(94)92861-4.

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Vejchapipat, Paisarn, Voranush Chongsrisawat, Apiradee Theamboonlers, Soottiporn Chittmittrapap, and Yong Poovorawan. "Elevated serum nitric oxide metabolites in biliary atresia." Pediatric Surgery International 22, no. 1 (2005): 106–9. http://dx.doi.org/10.1007/s00383-005-1581-8.

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Worrall, N. K., W. D. Lazenby, T. P. Misko, et al. "Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase." Journal of Experimental Medicine 181, no. 1 (1995): 63–70. http://dx.doi.org/10.1084/jem.181.1.63.

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The role of nitric oxide in the immune response to allogeneic tissue was explored in an in vivo cardiac transplant model in the rat. Nitric oxide production during organ rejection was demonstrated by elevations in systemic serum nitrite/nitrate levels and by electron paramagnetic resonance spectroscopy. Messenger RNA for the inducible nitric oxide synthase enzyme was detected in the rejecting allografted heart, but not in the nonrejecting isografted heart. The enzyme was demonstrated to be biologically active by the in vitro conversion of L-arginine to L-citrulline and was immunohistochemicall

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Ahmad, Waqas, Ibrahim Jantan, Endang Kumolosasi, and Syed Nasir Abbas Bukhari. "Standardized extract of Tinospora crispa stimulates innate and adaptive immune responses in Balb/c mice." Food & Function 7, no. 3 (2016): 1380–89. http://dx.doi.org/10.1039/c5fo01531f.

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Tinospora crispa extract exhibited immunostimulatory effects by promoting nitric oxide production ability, peritoneal macrophage phagocytosis, delayed type hypersensitivity, and enhancing serum immunoglobulins and serum lysozyme levels.

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