Relevant bibliographies by topics / Serum peptidome

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Serum peptidome'

Author: Grafiati
Published: 4 June 2021
Last updated: 12 February 2022

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Journal articles on the topic "Serum peptidome"

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Fan, Nai-Jun, Chun-Fang Gao, Xiu-Li Wang, Guang Zhao, Qing-Yin Liu, Yuan-Yao Zhang, and Bao-Guo Cheng. "Serum Peptidome Patterns of Colorectal Cancer Based on Magnetic Bead Separation and MALDI-TOF Mass Spectrometry Analysis." Journal of Biomedicine and Biotechnology 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/985020.

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Background. Colorectal cancer (CRC) is one of the most common cancers in the world, identification of biomarkers for early detection of CRC represents a relevant target. The present study aims to determine serum peptidome patterns for CRC diagnosis.Methods. The present work focused on serum proteomic analysis of 32 health volunteers and 38 CRC by ClinProt Kit combined with mass spectrometry. This approach allowed the construction of a peptide patterns able to differentiate the studied populations. An independent group of serum (including 33 health volunteers, 34 CRC, 16 colorectal adenoma, 36 esophageal carcinoma, and 31 gastric carcinoma samples) was used to verify the diagnostic and differential diagnostic capability of the peptidome patterns blindly. An immunoassay method was used to determine serum CEA of CRC and controls.Results. A quick classifier algorithm was used to construct the peptidome patterns for identification of CRC from controls. Two of the identified peaks at m/z 741 and 7772 were used to construct peptidome patterns, achieving an accuracy close to 100% (>CEA,P<0.05). Furthermore, the peptidome patterns could differentiate validation group with high accuracy.Conclusions. These results suggest that the ClinProt Kit combined with mass spectrometry yields significantly higher accuracy for the diagnosis and differential diagnosis of CRC.
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Villanueva, Josep, John Philip, Lin DeNoyer, and Paul Tempst. "Data analysis of assorted serum peptidome profiles." Nature Protocols 2, no. 3 (March 2007): 588–602. http://dx.doi.org/10.1038/nprot.2007.57.

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Yang, Juan, Shuan-Ying Yang, Xiao-Yan Hu, Shu-Fen Huo, Wen-Li Shang, Zong-Fang Li, Lei Ni, et al. "Serum Peptidome Profiling in Patients with Lung Cancer." Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 293, no. 12 (November 16, 2010): 2027–33. http://dx.doi.org/10.1002/ar.21267.

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Yang, Juan, Yong-Chun Song, Cheng-Xue Dang, Tu-Sheng Song, Zhi-Gang Liu, You-Min Guo, Zong-Fang Li, and Chen Huang. "Serum peptidome profiling in patients with gastric cancer." Clinical and Experimental Medicine 12, no. 2 (July 8, 2011): 79–87. http://dx.doi.org/10.1007/s10238-011-0149-2.

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Bai, Ju, Aili He, Wanggang Zhang, Yun Yang, Jianli Wang, Pengyu Zhang, Yuandong Feng, et al. "Serum Peptidome Based Multiple Myeloma Renal Impairment Biomarker Screening." Blood 126, no. 23 (December 3, 2015): 2968. http://dx.doi.org/10.1182/blood.v126.23.2968.2968.

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Abstract Background: Renal impairment (RI) is relatively common in patients with newly diagnosed MM (NDMM), ~20-40%, and forms one of the defining features for diagnosis of symptomatic disease. RI has a negative prognostic impact in patients with MM, with an increased risk of early death and a reduction in median survival of up to 50% compared with MM patients without RI. Identification of the early RI in MM and prompt intervention can effectively reverse the RI and prolong the survival of patients. Considering serum creatinine (SCr), blood urea nitrogen (BUN) and creatinine clearance (CrCl) are difficult to reflect early RI, cystatin C (Cys-C), as a new biomarker, has certain value for the diagnosis of early glomerular impairment in MM. However, the early stage of RI in MM was mainly renal tubular injury. Low molecular urine protein (retinol-binding protein, β-microglobulin) are effective in early renal tubular injury, but they are affected by urea PH value. This study was to screen a panel of serum peptides associated with early RI in MM. Methods: 164 MM patients were selected from those who were newly diagnosed in the Second Affiliated Hospital of Xi'an Jiao Tong University during a given period of time (2009.1-2014.1). Their diagnoses were made according to the diagnostic criteria from the International Myeloma Working Group. The median age was 65 years old (range 36-83) and 60.4% were male. RI was defined as having a CrCl<40ml/min. Weak cation exchange magnetic bead combined with matrix assisted laser desorption/ionization time of flight mass spectrometry were used to compare and analyze serum peptidome of MM with or without RI. Correlation analysis of two variables was estimated by Spearman method. The patients were categorized into two groups according to the relative intensities of peptides (≥mean versus <mean). Overall Survival was estimated by the Kaplan-Meier method and compared using a log-rank test. The event was defined as the time from initial diagnosis to treatment-related death time. Statistical significance was defined as p<0.05. Results: Serum peptidome of MM including 104 without RI and 50 with RI were analysed. 18 statistically different expressed peptide peaks were obtained in the molecular weight range of 700-10000Da (P<0.05), among which, 7 peptides were upregulated and 11 peptides were downregulated. Quick classifier (QC) model had optimal distinction efficiency, in the training set with a sensitivity of 93.33% and a specificity of 90%. Blind test verified that this model correctly identified 18 cases out of total 20 MM with RI and 70 cases from 74 MM without RI. Peptides with molecular weight of 3908.85Da and 3216.06Da were significant upregulated in MM patients with RI. Relative intensities of the two peptides were decreased when CrCl(38/50MM) was improved to 40ml/min after therapy. Peptide with molecular weight of 2990.08Da was significant downregulated in MM patients with RI. Its relative intensity was elevated after therapy(CrCl>40ml/min,38/50MM). Spearman correlation analysis showed that relative intensities of peptides with molecular weight of 3908.85Da, 3216.06Da and 2990.08Da were correlated with SCr(r=0.81, p<0.001; r=0.84, p<0.001; p=-0.86, p<0.001), CrCl(r=-0.79, p<0.001; r=-0.81, p<0.001; r=0.83, p<0.001), BUN(r=0.74, p<0.001; r=0.77, p<0.001; r=-0.79, p<0.001), Cys-C(r=0.81, p<0.001; r=0.84, p<0.001; r=-0.86, p<0.001). The median follow-up duration among 164 patients was 27 months (range 4-52 months). Kaplan-Meier analyses of overall survival (OS) showed that patients with higher relative intensities of peptide with 3908.85Da and 3216.06Da (≥mean relative intensity) had a significantly inferior outcome. Lower relative intensities of peptides with molecular weight of 3908.85Da and 3216.06Da (<mean relative intensity) was associated with a favorable OS (46.2±9.2% versus 16.1±6.5%, p=0.012; 41.7±9.5% versus 18.5±6.0%, P=0.021). The OS rate was higher in patients with increased relative intensity of peptides with molecular weight of 2990.08Da (≥mean relative intensity) of than in those with decreased relative intensity (<mean relative intensity)(36.1±10.5% versus 16.2±4.7%, p=0.008). Conclusion: Peptides(3908.85Da, 3216.06Da and 2990.08Da) associated with MM RI obtained by serum peptidome technology can provide new clue for early assess and diagnose MM RI in clinical. Disclosures No relevant conflicts of interest to declare.
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Zlotta, Alexandre R. "Differential Exoprotease Activities Confer Tumor-Specific Serum Peptidome Patterns." European Urology 49, no. 4 (April 2006): 756–57. http://dx.doi.org/10.1016/j.eururo.2006.02.005.

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Villanueva, J. "Differential exoprotease activities confer tumor-specific serum peptidome patterns." Journal of Clinical Investigation 116, no. 1 (December 8, 2005): 271–84. http://dx.doi.org/10.1172/jci26022.

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Zhou, Chun-Xue, Shi-Chen Xie, Man-Yao Li, Cui-Qin Huang, Huai-Yu Zhou, Hua Cong, Xing-Quan Zhu, and Wei Cong. "Analysis of the serum peptidome associated with Toxoplasma gondii infection." Journal of Proteomics 222 (June 2020): 103805. http://dx.doi.org/10.1016/j.jprot.2020.103805.

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Matysiak, Jan, Agata Światły, Joanna Hajduk, Joanna Matysiak, and Zenon Kokot. "Influence of Honeybee Sting on Peptidome Profile in Human Serum." Toxins 7, no. 5 (May 22, 2015): 1808–20. http://dx.doi.org/10.3390/toxins7051808.

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Gao, Yao, Lin Lin, Zhenzhen Huang, Yongjing Chen, and Wei Hang. "Peptidome workflow of serum and urine samples for biomarker discovery." Analytical Methods 3, no. 4 (2011): 773. http://dx.doi.org/10.1039/c0ay00705f.

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Dissertations / Theses on the topic "Serum peptidome"

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Alzaabi, Adhari Abdullah. "Identification and Characterization of Serum Biomarkers Associated with Breast Cancer Progression." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6452.

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Despite the recognized advances in the treatment of breast cancer, it still accounts for 15% of all cancer-related deaths. 90% of breast cancer deaths are due to unpredicted metastasis. There is neither successful treatment for metastatic patients nor a specific test to predict or detect secondary lesions. Patients with primary tumor will be either over-treated with cytotoxic side effects or under-treated and risk recurrence. This necessitates the need for personalized treatment, which is hard to offer for such heterogeneous disease. Obstacles in treating breast cancer metastasis are mainly due to the gaps exist in the understanding of the molecular mechanism of metastasis. The linear model of metastasis is supported by several observations that reflect an early crosstalk between the primary and secondary tumor, which in turn makes the secondary microenvironment fertile for the growth of disseminated cells. This communication occurs through circulation and utilizes molecules which have not been identified to date. Identifying such molecules may help in detecting initial stages of tumor colonization and predict the target organ of metastasis. Furthermore, these molecules may help to provide a personalized therapy that aims to tailor treatment according to the biology of the individual tumor. Advances in proteomics allows for more reproducible and sensitive biomarker discovery. Proteomic biomarkers are often more translatable to the clinic compared to biomarkers identified using other omics approaches. Further, protein biomarkers can be found in biological fluids making them a non-invasive way to treat or investigate cancer patients. We present in this manuscript our study of the use of a proteomic approach on blood serum samples of metastatic and non-metastatic patients using LC-MS/MS quantitative analysis machine to identify molecules that could be associated with different stages of breast cancer metastasis. We focused on the deferential expression of low molecular weight biomolecules known to reflect disease-specific signatures. We manually analyzed 2500 individual small biomolecules in each serum sample of total of 51 samples. Comparisons between different sample types (from stage I and III Breast Cancer patients in this case) allows for the detection of unique short peptide biomarkers present in one sample type. We built a multi-biomarker model with more sensitivity and specificity to identify the stage of the tumor and applied them on blinded set of samples to validate prediction power. We hope that our study will provide insights for future work on the collection, analysis, and understanding of role of molecules in metastatic breast cancer.
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Parker, Todd Avery. "Elucidating the immunoactivity of a goat serum peptide." Diss., Mississippi State : Mississippi State University, 2002. http://library.msstate.edu/etd/show.asp?etd=etd-03072002-141009.

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Nash, Ian Alun. "The development of solid phase strategies and methodologies : the synthesis of polyamine toxins and peptide nucleic acids." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321373.

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Ali, Stuart Alvaro. "Transferrin trojan horses : a novel approach for drug delivery?" Thesis, Brunel University, 1999. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285047.

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Huber, Alexander Domenico. "Purification of Phage-Displayed HSA-Specific Peptide for Biosensor Production." Youngstown State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1559730074086289.

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Kenney, Floyd E. "Biosensor Production By Conjugation Of HSA-Specific Peptide To Functionalized Nanotube Fiber." Youngstown State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1525360589515967.

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Masson, Catherine. "Purification et mode d'action d'un peptide sérique hyperglycémiant induit par la température." Nancy 1, 1990. http://www.theses.fr/1990NAN10294.

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Des travaux antérieurs ont montré qu'une hyperthermie localisée provoquait chez le rat une augmentation de la glycémie de 30 à 40%. De plus, l'injection de sérum de rat chauffé à 44#OC pendant 15 minutes à des rats normaux, entraînait également une hyperglycémie. Cet effet est lié à la présence d'un peptide dans le sérum chauffé, qui est appelée TIF (température induced factor). Dans ce travail, nous décrivons la purification de ce peptide en 4 étapes chromatographiques associant la filtration sur gel et la chromatographie liquide haute performance. Nous présentons ses propriétés physicochimiques et sa composition en acides aminés. Nous étudions les effets du sérum chauffé et du TIF sur le métabolisme glucidique du rat sain, par dosages de paramètres métaboliques (lactate, pyruvate, corps cétonique, acides aminés glucoformateurs) et hormonaux (insuline, glucagon) et étude de la cinétique de captation du glucose marqué au tritium. Une étude de l'effet hyperglycémiant, de la survie et de la taille tumorale est réalisée chez des rats porteurs de rhabdomyosarcome, et traités par injection de sérum chauffé
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Puckett, Nathan. "Effects of Binding Affinity between Bovine Serum Albumin and Platinum Drugs." TopSCHOLAR®, 2017. http://digitalcommons.wku.edu/theses/1977.

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Platinum complex drugs such as cisplatin have been used as highly successful chemotherapy drugs since the 1970s. We are interested in how the ligands attached to cisplatin analogs influences their reactivity with biologically relevant targets along with time and amount. For this study, reactions were conducted to determine the reactivity between different platinum compounds and the protein bovine serum albumin. Various platinum compounds with different ligands were reacted in varying amounts with albumin in ammonium acetate buffer for either 1 hour, 4 hours, or 24 hours. Each reaction was quenched after the designated reaction time by dialysis and the platinum bound to the protein was determined by use of ICP. LC-MS was used to find exact peptide residues platinum complexes prefer to bind with but was found to be ineffective. Results show that time has a more significant affect on binding over amount of platinum present. In respect to changing the leaving or carrier ligands on the platinum complex, these changes on the complex did not affect binding significantly with bovine serum albumin. Triamine platinum complexes also seem to bind significantly more than diamine platinum complexes along with anionic form platinum complexes binding significantly better than the cationic form platinum complexes.
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Mitchell, Emma. "Serum calcitonin gene-related peptide concentrations in the horse and their relationship to the Systemic Inflammatory response." Thesis, Virginia Tech, 2006. http://hdl.handle.net/10919/33834.

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Systemic inflammation is a leading cause of mortality and morbidity in both human and equine intensive care patients. This systemic inflammatory response may be due to insult from bacterial, viral, fungal or parasitic invasion or from trauma or hypoxemia. Local and systemic release of a wide variety of endogenous pro-inflammatory mediators results in activation of the innate immune system in order to resolve the insult. In sepsis this initial appropriate host response becomes amplified and deregulated leading to refractory hypotension and multiple organ dysfunction. The exact incidence of sepsis (SIRS due to bacterial infection) has not been reported in the equine literature (Roy 2004). Since early recognition and treatment of sepsis are associated with improved outcome the search for markers to accurately predict presence of sepsis and likelihood of survival continues. The serum concentration of both procalcitonin and its related molecule CGRP have been documented to increase in humans with SIRS, yet no literature exists as to the production or role of CGRP in equine patients with SIRS. This study showed that equine CGRP was produced in detectable quantities by healthy adult horses and neonatal foals less than two weeks of age using a rat á-CGRP ELISA. The low percentage recovery of CGRP from samples and the high lower limit of detection for the assay prevented establishment of a normal concentration range of CGRP in healthy horses. In both adult horses and foals with documented SIRS, CGRP concentrations were significantly increased at time of presentation to the hospital (p<0.0002, p<0.003 respectively). A trend towards increased serum CGRP concentration was present in anaesethized horses exposed to endotoxin, but this was not statistically significant (p< 0.067).
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Pham, Errek Manh Trung. "Producing A Peptide For Use In A Blood Biosensor For Injury Detection." Youngstown State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1607519672342672.

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Books on the topic "Serum peptidome"

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Allinson, Erica Tracey. Rapid induction of parathyroid hormone-like peptide gene expression by serum and growth factors. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1992.

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Collins, Patrick J. The study of a new and specific proline cleaving peptidase from bovine serum. 2003.

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Chang, Yung-jin. Production of peptide growth factors by oncogene-transformed balb serum-free mouse embryo cells. 1988.

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McLean, Anthony S., and Stephen J. Huang. Cardiac injury biomarkers in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0301.

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To be clinically relevant, a good cardiac biomarker should have four main characteristics. It should be organ-, disease- and stage-specific to be useful in diagnosis. Its release should be timely and its half-life should be long enough to make measurement possible and meaningful. Its serum or blood concentration should be proportional to disease severity; hence, can be used as a monitoring tool. Finally, their concentrations have implications on long-term outcomes. To date, only a handful of cardiac biomarkers have clinical relevance in the intensive care setting—cardiac troponins (as a marker of cardiac injury) and B-type natriuretic peptide (as a marker of cardiac stress) being probably the most useful. However, cautious interpretations of these biomarkers are needed in intensive care patients as several confounding factors can affect their concentrations.
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Malyszko, Jolanta, and Iain C. Macdougall. Iron metabolism in chronic kidney disease. Edited by David J. Goldsmith. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0125.

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While whole-body (‘absolute’) iron deficiency is common and probably increased in frequency in chronic kidney disease (CKD), functional iron deficiency is a particular problem in CKD. Absolute iron deficiency is likely to be present in advanced CKD when the ferritin falls below 100 ng/mL and the TSAT falls below 20%. Functional iron deficiency is characterized by the presence of adequate iron stores (as defined by conventional criteria), but with an inability to mobilize this iron rapidly enough to adequately support erythropoiesis with the administration of erythropoietin. Among such patients, the serum ferritin level is either normal or elevated (usually between 100 and 800 ng/mL), with a TSAT typically ≤20%. Hepcidin, a novel peptide discovered at the turn of the twenty-first century, is an iron gatekeeper that plays a key role in functional iron deficiency, and the ‘anaemia of chronic disease’. The main function of hepcidin is homeostatic regulation of iron metabolism and mediation of host defence and inflammation. Hepcidin is the predominant negative regulator of iron absorption in the small intestine, iron transport across the placenta, and iron release from the macrophages. Novel strategies that modulate hepcidin and its target ferroportin for the treatment of anaemia of chronic diseases are currently undergoing extensive research.
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Book chapters on the topic "Serum peptidome"

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Jenssen, Håvard, and Stein Ivar Aspmo. "Serum Stability of Peptides." In Peptide-Based Drug Design, 177–86. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-419-3_10.

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Suganuma, Hiroyuki, Etsuko Fujiu, Akira Shiota, Fumito Tani, Kazuyoshi Kurahashi, Hachiro Usui, Hideo Chiba, and Masaaki Yoshikawa. "Ileum and vasoactive peptides derived from serum albumin." In Peptide Chemistry 1992, 612–14. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1474-5_176.

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Tachibana, Shinro, Tomoko Hosoya, Manabu Kuwada, Yasutsugu Shimonishi, and Toshifumi Takao. "Purification and structure of SPAI-like immunoreactivity in porcine serum." In Peptide Chemistry 1992, 562–67. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1474-5_163.

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Andresen, Heiko, and Frank F. Bier. "Peptide Microarrays for Serum Antibody Diagnostics." In Methods in Molecular Biology, 123–34. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-372-1_8.

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Fridkin, Mati, Oren Rosen, Pavel Landsmann, Liana Preciado-Patt, Esther Tzehoval, Lea Eisenbach, Talia Hahn, et al. "Enzymatic processing of serum proteins: A route to peptides associated with host defense." In Peptide Chemistry 1992, 637–42. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1474-5_182.

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Heding, L. G. "Radioimmunological Determination of Human C-Peptide in Serum." In Radioimmunoassays for Insulin, C-Peptide and Proinsulin, 48–55. Dordrecht: Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-011-7094-9_10.

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Heding, L. G. "Specific and Direct Radioimmunoassay for Human Proinsulin in Serum." In Radioimmunoassays for Insulin, C-Peptide and Proinsulin, 56–63. Dordrecht: Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-011-7094-9_11.

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Hedïng, Lise G. "Determination of Total Serum Insulin (IRI) in Insulin-treated Diabetic Patients." In Radioimmunoassays for Insulin, C-Peptide and Proinsulin, 36–42. Dordrecht: Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-011-7094-9_8.

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Knol, Jaco C., and Connie R. Jimenez. "MALDI-TOF Serum Profiling Using Semiautomated Serum Peptide Capture with Magnetic Reversed Phase (C18) Beads." In Methods in Molecular Biology, 3–16. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-319-6_1.

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Carney, D. N., G. Bepler, and A. F. Gazdar. "The Serum-Free Establishment and in Vitro Growth Properties of Classic and Variant Small Cell Lung Cancer Cell Lines." In Peptide Hormones in Lung Cancer, 157–66. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-82533-0_16.

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Conference papers on the topic "Serum peptidome"

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Jia, Kun, Wei Li, Feng Wang, Fang Liu, Xiaofei Liu, Yuanyuan Qiao, Yang Xu, et al. "Abstract 1565: Magnetic bead-based serum peptidome profiling for identifying potential biomarkers in esophageal squamous cell carcinoma." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1565.

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Rasaputra, Komal S., Rohana Liyanage, Ron Okimoto, Jackson O. Lay, Narayan C. Rath, and Olga Tarasenko. "SERUM PEPTIDE CHANGES IN CHICKENS WITH METABOLIC SKELETAL PROBLEMS ASSOCIATED WITH LAMENESS." In BIOLOGY, NANOTECHNOLOGY, TOXICOLOGY, AND APPLICATIONS: Proceedings of the 5th BioNanoTox and Applications International Research Conference. AIP, 2011. http://dx.doi.org/10.1063/1.3587475.

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Lo, Ken C., John C. Tan, Eric Sullivan, Ryan Bannen, Todd Richmond, Florian Grupp, Stefan Weiser, Dieter Heindl, Klaus-Peter Stengele, and Albert Thomas. "Abstract A156: Anti-p53 auto-antibody serum profiling using high-density peptide arrays." In Abstracts: CRI-CIMT-EATI-AACR Inaugural International Cancer Immunotherapy Conference: Translating Science into Survival; September 16-19, 2015; New York, NY. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/2326-6074.cricimteatiaacr15-a156.

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Liu, Jikun, Chien-Fu Chen, Chien-Cheng Chang, and Don L. DeVoe. "Isoelectric Focusing-Reversed Phase Liquid Chromatography Polymer Microchip With Integrated High-Pressure Valves." In ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-12147.

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A cyclicolefin polymer (COP) microchip supporting parallel 2-D peptide separations is described. By combining isoelectric focusing (IEF) as a first dimension and parallel reversed-phase liquid chromatography (RPLC) as a second dimension, the system enables efficient high-throughput fractionation prior to mass spectrometry in support of peptide mass fingerprinting for global proteomic analysis from highly limited specimens. The IEF-RPLC chip incorporates high-pressure micro shut-off valves, allowing uniform sample transfer and gradient elution from each micro LC column, and ensuring hydrodynamic isolation between the separation dimensions. The utility of the initial microchip is demonstrated by separation of a fluorescein labeled bovine serum albumin tryptic digest in a chip containing a five channel RPLC array.
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Zeng, H. "AB0222 The serum anti-citrullinated protein/peptide antibodies in children with juvenile idiopathic arthritis." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.2058.

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Bauer, K. A., B. L. Kass, M. Bednarek, M. Kloczewiak, J. Hawiger, and R. D. Rosenberg. "DETECTION OF FACTOR X ACTIVATION IN HUMANS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643828.

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The activation of factor X by factor VII/VIIa-tissue factor or factor IXa plays a pivotal role in the hemostatic mechanism. This reaction results in the liberation of a peptide from the zymogen for which we have developed a sensitive and specific radioimmunoassay (RIA), The native peptide was purified from activated human factor X by hydroxylapatite chromatography and reverse-phase high pressure liquid chromatography (HPLC). Gel filtration experiments demonstrated that the peptide was not physically associated with the enzyme. A 15 amino acid peptide with the COOH-terminal sequence of the activation fragment was synthesized using the solid-phase method of Merrifield. Antisera were raised in rabbits to the synthetic analogue coupled to bovine serum albumin with glutaraldehyde. The antibody population obtained was used to construct a double antibody RIA and was able to measure as little as 0.02 nM of this component. The antibody reactivity toward the factor X zymogen was negligible (less than 1/36,000 that of the activation peptide on a molar basis). However because other plasma constituents contributed to a nonspecific basal signal in the RIA, we developed an extraction procedure for the native peptide utilizing perchloric acid. Plasma peptide levels in normal individuals were ∼0.1 nM, and elevations up to 0.8 nM were observed in patients with evidence of disseminated intravascular coagulation. Individuals chronically anticoagulated with coumarin derivatives had plasma levels of this peptide suppressed to ∼0.02 nM. The validity of our measurements of factor X activation in vivo is supported by the fact that the immunoreactive signal migrates on reverse-phase HPLC in a manner identical to that of the native activation peptide and can be quantitatively recovered. This assay should be useful for studying the pathophysiology of thrombotic as well as bleeding disorders in humans.
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7

HAYAMA, S., K. MORIYAMA, and S. KITAJIMA. "HIGHLY SENSITIVE CLEIA FOR C-PEPTIDE IN SERUM WITH CHEMILUMINESCENT SUBSTRATE USING A NEW CLEIA SYSTEM." In Proceedings of the 13th International Symposium. WORLD SCIENTIFIC, 2005. http://dx.doi.org/10.1142/9789812702203_0111.

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8

Szczeklik, A., K. Sladek, and J. Dropinski. "IgE-MEDIATED IMMUNOLOGICAL RESPONSE IN MYOCARDIAL INFARCTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643022.

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Mast cells have been described in adventitia of coronary arteries; their number increases with progression of atherosclerosis. We reasoned that, if these cells were to contribute to cardiac pathology, the signals turning them on should be detectable in the blood. We, therefore, measured systematically serum IgE in 25 patients (18 men and 7 women, mean age 55 years) with unequivocal diagnosis of recent transmural myocardial infarction. All patients survived. When specifically interviewed, only two gave a history compatible with atopy. In 14 patients, whose initial values ranged from 44-750 IU/ml, and on average 172 IU/ml, serum IgE increased by more than 25%. It raised gradually after the infarction,reaching the peak by 7th day (mean increase by 92%), then began to decrease, but was still elevated on 14th and 21st day. Such behaviour was in striking contrast to mean serum IgG which at no time showed changes differing by more than 10% from the initial values. Thus, in at least half of the patients with acute myocardial infarction there occurs an immunological reaction characterized by distinct release of IgE into circulatory blood. It might be that IgE sensitizes mast cells and facilitates the release of chemical mediators. Histamine, prostaglandin D2 and sulfido-peptide leukotrienes are all powerful vasoconstrictors of human arteries. On the other hand, heparin exerts potent anticoagulant effects through activation of antithrombin III, and PGD2 inhibits platelet aggregation. This complex interplay of the mediators at the target site might affect blood clotting, cardiac function and the course of myocardial infarction.
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9

Farrokh, Ali, Vasilios Sierros, Erik Fernandez, and Douglas Marania. "The Role For Serum Brain Natriuretic Peptide In Patients With Acute Exacerbation Of Chronic Obstructive Pulmonary Disease." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2385.

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10

Evely, R. S., F. E. Preston, D. R. Triger, C. R. M. Hay, M. C. Greves, and J. C. E. Underwood. "TYPE III PRO-COLLAGEN PEPTIDE IN LIVER DISEASE IN HAEMOPHILIA." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644022.

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During the past 10 years we have carried out liver biopsies on haemophiliacs with biochemical evidence of chronic liver disease (CLD). To date 44 biopsies have been obtained from 35 patients. Histological diagnoses are Chronic Persistent Hepatitis (CPH) 24, Chronic Aggressive Hepatitis (CAH) 11 and Cirrhosis 9. Serial biopsies indicate that progressive liver disease is now a serious problem in haemophilia. Liver biopsy is not without risk and therefore it is important to identify factors which may be of value in predicting the nature of the liver disease or its progression. Since intra-hepatic fibrosis is a feature of CLD we measured Type III amino terminal propeptide of pro-collagen (PC III) by radio-immunoassay on samples taken within a mean of 4.8 months of the liver biopsy. A normal range was established as 4.3 - 15.7ng/ml on healthy subjects (median 7.0). Median values and ranges for patients with CPH (N=13), CAH (N=5) and cirrhosis (N=5) were 8 (5.4 - 23.4), 14.2 (7.2 - 19.8) and 14.2 (11.2 - 23.0)ng/ml respectively. Although pro-collagen III values tended to be higher in progressive liver disease (CAH and cirrhosis) this did not reach statistical significance. It would, therefore, appear that unlike serum IgG, pro-collagen III will not be a valuable predictor of progressive liver disease in haemophilia. A larger study is necessary to clarify this.
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