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Journal articles on the topic 'Serum starvation'

Author: Grafiati
Published: 31 May 2025
Last updated: 31 July 2025

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1

Wang, Yi, Juan Gao, Bojun Fan, et al. "Effects of Long-Term Serum Starvation on Autophagy, Metabolism, and Differentiation of Porcine Skeletal Muscle Satellite Cells." Veterinary Sciences 12, no. 1 (2024): 11. https://doi.org/10.3390/vetsci12010011.

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This study investigated the effects of long-term serum starvation on autophagy, metabolism, and differentiation of porcine skeletal muscle satellite cells (SMSCs) and elucidated the role of autophagy in skeletal muscle development. Our findings provide a theoretical basis for improving meat production in domestic pigs. The SMSCs isolated and preserved in our laboratory were revived and divided into six groups based on the culture medium serum concentration to simulate varying levels of serum starvation: 20% serum (control group), 15% serum (mild serum starvation group), 5% serum (severe serum
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2

Pirkmajer, Sergej, and Alexander V. Chibalin. "Serum starvation: caveat emptor." American Journal of Physiology-Cell Physiology 301, no. 2 (2011): C272—C279. http://dx.doi.org/10.1152/ajpcell.00091.2011.

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Serum starvation is one of the most frequently performed procedures in molecular biology and there are literally thousands of research papers reporting its use. In fact, this method has become so ingrained in certain areas of research that reports often simply state that cells were serum starved without providing any factual details as to how the procedure was carried out. Even so, we quite obviously lack unequivocal terminology, standard protocols, and perhaps most surprisingly, a common conceptual basis when performing serum starvation. Such inconsistencies not only hinder interstudy compara
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Ching, James Kain, Pooja Rajguru, Nandhini Marupudi, Sankha Banerjee, and Jonathan S. Fisher. "A role for AMPK in increased insulin action after serum starvation." American Journal of Physiology-Cell Physiology 299, no. 5 (2010): C1171—C1179. http://dx.doi.org/10.1152/ajpcell.00514.2009.

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Serum starvation is a common cell culture procedure for increasing cellular response to insulin, though the mechanism for the serum starvation effect is not understood. We hypothesized that factors known to potentiate insulin action [e.g., AMP-activated protein kinase (AMPK) and p38] or to be involved in insulin signaling leading to glucose transport [e.g., Akt, PKCζ, AS160, and ataxia telangiectasia mutated (ATM)] would be phosphorylated during serum starvation and would be responsible for increased insulin action after serum starvation. L6 myotubes were incubated in serum-containing or serum
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Dong, Su, Andrew Khoo, Jianxin Wei, et al. "Serum starvation regulates E-cadherin upregulation via activation of c-Src in non-small-cell lung cancer A549 cells." American Journal of Physiology-Cell Physiology 307, no. 9 (2014): C893—C899. http://dx.doi.org/10.1152/ajpcell.00132.2014.

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E-cadherin is essential for the integrity of adherens junctions between lung epithelial cells, and the loss of E-cadherin allows cell motility and is thought to promote lung cancer metastasis. While the downregulation of E-cadherin expression has been well characterized and is seen with transforming growth factor-β1 (TGF-β1) exposure, few studies have focused on E-cadherin upregulation. Here, we show that serum starvation causes increased E-cadherin expression via the activation of c-Src kinase in non-small-cell lung cancer A549 cells. Serum starvation increased E-cadherin protein levels in a
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5

Concepcion, Marc B., and David R. Nelson. "Expression of spoT in Borrelia burgdorferi during Serum Starvation." Journal of Bacteriology 185, no. 2 (2003): 444–52. http://dx.doi.org/10.1128/jb.185.2.444-452.2003.

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ABSTRACT Borrelia burgdorferi, the causative agent of Lyme disease, is transmitted by the tick Ixodes scapularis. A 2.9-kb fragment containing a putative spoT gene was isolated from B. burgdorferi genomic DNA by PCR amplification and cloned into a pBAD24 vector. The cloned gene complemented Escherichia coli mutant strain CF1693, which contains deletions of both the relA and spoT genes. The spoT gene in E. coli encodes a bifunctional enzyme capable of synthesizing and degrading (p)ppGpp, which mediates the stringent response during carbon source starvation. B. burgdorferi has been reported to h
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Sadeghian-Nodoushan, Fatemeh, Poopak Eftekhari-Yazdi, Azam Dalman, Hossein Eimani, and Houri Sepehri. "Mimosine As Well As Serum Starvation Can Be Used for Cell Cycle Synchronization of Sheep Granulosa Cells." Chinese Journal of Biology 2014 (January 2, 2014): 1–7. http://dx.doi.org/10.1155/2014/851736.

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This study was evaluated the effect of different synchronization protocols such as serum starvation for 1–3 days, confluency and chemical inhibitors on synchronization accuracy at G0/G1, apoptosis, and DNA synthesis in sheep granulosa cells. The cells were obtained from ovarian antral follicles of slaughtered sheep and used at first and fifth passages. Flow cytometry analysis showed that confluent cells, serum starvation for 24, 48, and 72 hours, and mimosine treatment significantly increased G0/G1 phase cells when compared to normally growing cells (P<0.05). Nocodazole treatment increased
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7

Jungers, Courtney F., Jonah M. Elliff, Daniela S. Masson-Meyers, Christopher J. Phiel, and Sofia Origanti. "Regulation of eukaryotic translation initiation factor 6 dynamics through multisite phosphorylation by GSK3." Journal of Biological Chemistry 295, no. 36 (2020): 12796–813. http://dx.doi.org/10.1074/jbc.ra120.013324.

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Eukaryotic translation initiation factor 6 (eIF6) is essential for the synthesis of 60S ribosomal subunits and for regulating the association of 60S and 40S subunits. A mechanistic understanding of how eIF6 modulates translation in response to stress, specifically starvation-induced stress, is lacking. We here show a novel mode of eIF6 regulation by glycogen synthase kinase 3 (GSK3) that is predominantly active in response to serum starvation. Both GSK3α and GSK3β phosphorylate human eIF6. Multiple residues in the C terminus of eIF6 are phosphorylated by GSK3 in a sequential manner. In respons
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8

Wittenstein, Amnon, Michal Caspi, Yifat David, Yamit Shorer, Prathamesh T. Nadar-Ponniah, and Rina Rosin-Arbesfeld. "Serum starvation enhances nonsense mutation readthrough." Journal of Molecular Medicine 97, no. 12 (2019): 1695–710. http://dx.doi.org/10.1007/s00109-019-01847-0.

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9

An, So-Young, Hyun-Kyoung Yoon, Kyoung-Sook Kim, et al. "Upregulation of human GD3 synthase (hST8Sia I) gene expression during serum starvation-induced osteoblastic differentiation of MG-63 cells." PLOS ONE 18, no. 11 (2023): e0293321. http://dx.doi.org/10.1371/journal.pone.0293321.

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In this study, we have firstly elucidated that serum starvation augmented the levels of human GD3 synthase (hST8Sia I) gene and ganglioside GD3 expression as well as bone morphogenic protein-2 and osteocalcin expression during MG-63 cell differentiation using RT-PCR, qPCR, Western blot and immunofluorescence microscopy. To evaluate upregulation of hST8Sia I gene during MG-63 cell differentiation by serum starvation, promoter area of the hST8Sia I gene was functionally analyzed. Promoter analysis using luciferase reporter assay system harboring various constructs of the hST8Sia I gene proved th
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Kim, Hak-Ryul, Ju-Ah Jeong, Chan-Hee Park, Suk-Kyeong Lee, Won-Keun Lee, and Yong-Suk Jang. "A role for cell cycle proteins in the serum-starvation resistance of Epstein–Barr virus immortalized B lymphocytes." Biochemistry and Cell Biology 80, no. 4 (2002): 407–13. http://dx.doi.org/10.1139/o02-085.

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Epstein–Barr virus (EBV) is a B-lymphotropic human herpes virus that infects B lymphocytes and is associated with a broad spectrum of benign and malignant diseases. B cell infection by EBV causes indefinite cell proliferation that results in the development of immortalized lymphoblastoid cell lines (LCLs). We found that SNU-1103, a latency type III EBV-transformed LCL developed from a Korean cancer patient, resisted the G1 arrest that was normally caused by serum starvation. Western blot analyses revealed several alterations in the expression of key regulatory cell cycle proteins involved in t
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Li, Liming, Xiaqing Liu, Mingguang Zhao, Peng Guo, and Haifeng Zhang. "Effects of serum starvation and vascular endothelial growth factor stimulation on the expression of Notch signalling pathway components." Science Progress 104, no. 3 (2021): 003685042110283. http://dx.doi.org/10.1177/00368504211028387.

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Brain arteriovenous malformation (BAVM) is an abnormality in the cerebral vascular system. Although the upregulation of the Notch signalling pathway is a deterministic factor in BAVM, the mechanism by which this pathway is upregulated in patients with BAVM is uncertain. The effects of serum starvation and vascular endothelial growth factor (VEGF) stimulation on the Notch signalling pathway in brain microvascular endothelial cells (MECs) and mouse embryonic stem (mES)/embryoid body (EB)-derived endothelial cells were investigated in this study. The duration of serum starvation and VEGF concentr
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12

Cherkasova, Viktoriia, Yaroslav Ilnytskyy, Olga Kovalchuk, and Igor Kovalchuk. "Transcriptome Analysis of Cisplatin, Cannabidiol, and Intermittent Serum Starvation Alone and in Various Combinations on Colorectal Cancer Cells." International Journal of Molecular Sciences 24, no. 19 (2023): 14743. http://dx.doi.org/10.3390/ijms241914743.

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Platinum-derived chemotherapy medications are often combined with other conventional therapies for treating different tumors, including colorectal cancer. However, the development of drug resistance and multiple adverse effects remain common in clinical settings. Thus, there is a necessity to find novel treatments and drug combinations that could effectively target colorectal cancer cells and lower the probability of disease relapse. To find potential synergistic interaction, we designed multiple different combinations between cisplatin, cannabidiol, and intermittent serum starvation on colore
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13

Xu, Juan, Gaoxiang Huang, Zongjing Zhang, et al. "Up-Regulation of Glioma-Associated Oncogene Homolog 1 Expression by Serum Starvation Promotes Cell Survival in ER-Positive Breast Cancer Cells." Cellular Physiology and Biochemistry 36, no. 5 (2015): 1862–76. http://dx.doi.org/10.1159/000430156.

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Background/Aims: Cancer cells are resistant to ischemia and starvation. Glioma-associated oncogene homolog 1 (Gli1) is a positive transcriptional activator of Hedgehog (Hh) pathway and plays an essential role in the development of cancers, including breast cancer. However, how Gli1 promotes cell survival remains elusive. The main purpose of this study is to investigate the pro-survival effect of Gli1 under serum starvation and its molecular mechanism in ER-positive breast cancer cells. Methods: Gene expression was determined by quantitative real-time PCR (QRT-PCR) and Western blot. The surviva
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Katoh, Norio, Seijiro Minoura, Eiji Uchida, and Kiyoshi Takahashi. "Effect of estradiol administration and subsequent nonfeeding on liver estrogen receptor, serum apolipoprotein B-100, and serum triglycerides concentrations in steers." American Journal of Veterinary Research 54, no. 9 (1993): 1476–82. http://dx.doi.org/10.2460/ajvr.1993.54.09.1476.

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Summary Estradiol was administered to 3 steers (0.12 mg/kg of body weight/d for 14 consecutive days), followed by 2 days of nonfeeding (starvation). During estradiol administration, liver nuclear estrogen receptor and serum apolipoprotein B-100 (apoB-100), as well as serum triglycerides concentrations were increased, compared with values before administration. Starvation, together with interruption of estradiol administration, resulted in rapid decreases of the receptor, serum apoB-100, and serum triglycerides concentrations, and increase of nonesterified fatty acids concentration. Of the 3 st
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Asti, Anna Lia, Stefania Croce, Chiara Valsecchi, et al. "Characterization of Mesenchymal Stromal Cells after Serum Starvation for Extracellular Vesicle Production." Applied Sciences 14, no. 13 (2024): 5821. http://dx.doi.org/10.3390/app14135821.

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It has been demonstrated that mesenchymal stromal cells (MSCs) act by releasing bioactive molecules, among these are extracellular vesicles (EVs). The MSC-EVs are considered a convenient alternative to cell therapy, showing several functional characteristics of their origin cells. EVs can be collected from conditioned in vitro cultured MSCs. Different processes have been developed to induce in vitro EV release, and these approaches have been demonstrated to also influence MSC potentialities. This study aimed to investigate the effect of serum starvation on MSC characteristics. The morphology,
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Abdulghany, Zaynab, and Noah. "Determine MAO gene expression in both starved and non-starved glioblastoma cancer cell line." Iraqi Journal of Cancer and Medical Genetics 16, no. 1 (2023): 14–18. http://dx.doi.org/10.29409/ijcmg.v16i1.256.

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The relationship between cancer cell aggression induced by serum starvation and cell metastasis has been studied. Serum starvation is a typical way of inducing tumor cell apoptosis and stress may affecting on cell growth. Deprivation of serum from glioblastoma cancer cell line (AMGM) cultured media was tested after three different duration, the comparison of MAO gene expression between starved and non-starved glioblastoma cell line were measured using real-time PCR. The results indicated an increase in MAO gene expression in serum deprivation from cultured cells compared to non-starved cancer
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Lorenz, Mario, Raphaela Fritsche-Guenther, Cornelia Bartsch, et al. "Serum Starvation Accelerates Intracellular Metabolism in Endothelial Cells." International Journal of Molecular Sciences 24, no. 2 (2023): 1189. http://dx.doi.org/10.3390/ijms24021189.

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Periods of low energy supply are challenging conditions for organisms and cells during fasting or famine. Although changes in nutrient levels in the blood are first sensed by endothelial cells, studies on their metabolic adaptations to diminished energy supply are lacking. We analyzed the dynamic metabolic activity of human umbilical vein endothelial cells (HUVECs) in basal conditions and after serum starvation. Metabolites of glycolysis, the tricarboxylic acid (TCA) cycle, and the glycerol pathway showed lower levels after serum starvation, whereas amino acids had increased levels. A metaboli
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Sekiguchi, Kazuhito, Hiroaki Miyahara, Masanori Inoue, et al. "Metabolome Characteristics of Liver Autophagy Deficiency under Starvation Conditions in Infancy." Nutrients 13, no. 9 (2021): 3026. http://dx.doi.org/10.3390/nu13093026.

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The liver function is essential for metabolism, detoxification, and bile synthesis, even in the neonatal period. Autophagy plays significance roles in THE adult liver, whereas the role of liver autophagy in the early neonatal period largely remains unclear. To clarify the importance of liver autophagy in the neonatal starvation period, we generated liver-specific autophagy-deficient (Atg5flox/flox; Albumin-Cre) mice and investigated under starvation conditions comparing with control (Atg5flox/+; Albumin-Cre) mice, focusing on serum metabolites and liver histopathology. As a result, autophagy i
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Stavropoulou, A. V., O. Mavrofrydi, P. Saftig, and S. Efthimiopoulos. "Serum Starvation Induces BACE1 Processing and Secretion." Current Alzheimer Research 14, no. 4 (2017): 453–59. http://dx.doi.org/10.2174/1567205013666161026091530.

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Background: β-secretase (BACE1) is a type 1 transmembrane protein implicated in Alzheimer’s Disease (AD) pathogenesis. Cleavage of Amyloid Precursor Protein (APP), initiated by BACE1 and followed by γ-secretase, leads to the formation of toxic Aβ peptides. Increased levels of BACE1 have been detected in the CSF of AD patients compared to age-matched healthy controls indicating that neurodegenerative conditions induce shedding of BACE1. Objective: To mimic such conditions, we examined whether serum deprivation stimulates proteolysis-dependent secretion of BACE1. Method: Detection of BACE1 secre
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Ji, Kon-Young, Ki Mo Kim, Yun Hee Kim, et al. "Serum Starvation Sensitizes Anticancer Effect of Anemarrhena asphodeloides via p38/JNK-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells." American Journal of Chinese Medicine 49, no. 04 (2021): 1001–16. http://dx.doi.org/10.1142/s0192415x21500488.

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The molecular mechanism underlying the anticancer effects of Anemarrhena asphodeloides (A. asphodeloides) on colon cancer is unknown. This is the first study evaluating the anticancer effect of A. asphodeloides extract (AA-Ex) in serum-starved colorectal cancer cells. Changes in cell proliferation and morphology in serum-starved MC38 and HCT116 colorectal cancer cells were investigated using MTS assay. Cell cycle and apoptosis were investigated using flow cytometry, and cell cycle regulator expression was determined using qRT-PCR. Apoptosis regulator protein levels and mitogen-activated protei
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Ahmadiankia, Naghmeh, Mehdi Bagheri, and Mozhgan Fazli. "Differential migration-related gene expression and altered cytokine secretion in response to serum starvation in cultured MDA-MB-231 cells." Asian Biomedicine 13, no. 4 (2020): 123–29. http://dx.doi.org/10.1515/abm-2019-0051.

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AbstractBackgroundSerum starvation is mostly considered as a standard preparatory method in many cellular and molecular experiments. However, recent studies give some evidence that serum starvation is a major event that triggers various cell responses and has therefore great potential to change and interfere with the experimental results. In this study, the behavior of breast cancer cells in serum-starved condition was examined.ObjectiveTo focus on the role of serum starvation on cell migration and also the possible changes in the expression and secretion of genes and cytokines mostly involved
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Chen, Rui, Yilong Zou, Dongxue Mao, et al. "The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation." Journal of Cell Biology 206, no. 2 (2014): 173–82. http://dx.doi.org/10.1083/jcb.201403009.

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Organisms have evolved elaborate mechanisms to adjust intracellular nutrient levels in response to fluctuating availability of exogenous nutrients. During starvation, cells can enhance amino acid uptake and synthesis through the general amino acid control (GAAC) pathway, whereas nonessential cellular contents are recycled by autophagy. How these two pathways are coordinated in response to starvation is currently unknown. Here we show that the GAAC pathway couples exogenous amino acid availability with autophagy. Starvation caused deactivation of mTOR, which then activated autophagy. In paralle
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Scheubeck, Gabriel, Susanne Berchtold, Irina Smirnow, Andrea Schenk, Julia Beil, and Ulrich M. Lauer. "Starvation-Induced Differential Virotherapy Using an Oncolytic Measles Vaccine Virus." Viruses 11, no. 7 (2019): 614. http://dx.doi.org/10.3390/v11070614.

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Starvation sensitizes tumor cells to chemotherapy while protecting normal cells at the same time, a phenomenon defined as differential stress resistance. In this study, we analyzed if starvation would also increase the oncolytic potential of an oncolytic measles vaccine virus (MeV-GFP) while protecting normal cells against off-target lysis. Human colorectal carcinoma (CRC) cell lines as well as human normal colon cell lines were subjected to various starvation regimes and infected with MeV-GFP. The applied fasting regimes were either short-term (24 h pre-infection) or long-term (24 h pre- plus
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Bird, R. Curtis, Tzyy-Yun Tzeng Kung, Gin Wu, and Randy R. Young-White. "Variations in c-fos mRNA expression during serum induction and the synchronous cell cycle." Biochemistry and Cell Biology 68, no. 5 (1990): 858–62. http://dx.doi.org/10.1139/o90-127.

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Induction of c-fos mRNA levels associated with the stimulation of growth by fetal bovine serum following quiescence was examined in three cell types following brief (24 h) serum starvation. Starved NIH-3T3 and HeLa S3 cells experienced c-fos mRNA induction 20–30 min after addition of serum. In contrast, Swiss-3T3 cells expressed c-fos constitutively following serum starvation. The pattern of oncogene expression coincided with the level of quiescence of each cell line prior to induction. Serum induction of c-fos expression was dependent upon the response of each cell line to serum starvation, c
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Goyeneche, Alicia A., Jacquelyn M. Harmon, and Carlos M. Telleria. "Cell death induced by serum deprivation in luteal cells involves the intrinsic pathway of apoptosis." Reproduction 131, no. 1 (2006): 103–11. http://dx.doi.org/10.1530/rep.1.00751.

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The corpus luteum is a transient endocrine gland specializing in the production of progesterone. The regression of the corpus luteum involves an abrupt decline in its capacity for producing progesterone followed by its structural involution, which is associated with apoptosis of the luteal cells. An in vitro experimental approach is needed to study the molecular mechanisms underlying hormonal regulation of luteal cell death under defined experimental conditions. In this study, we investigated simian virus-40-transformed luteal cells to determine whether they can be driven to apoptosis and, if
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Piccolo, Simona, Giulio Grieco, Caterina Visconte, et al. "Starvation and Inflammation Modulate Adipose Mesenchymal Stromal Cells’ Molecular Signature." Journal of Personalized Medicine 14, no. 8 (2024): 847. http://dx.doi.org/10.3390/jpm14080847.

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Mesenchymal stromal cells (MSCs) and their released factors (secretome) are intriguing options for regenerative medicine approaches based on the management of inflammation and tissue restoration, as in joint disorders like osteoarthritis (OA). Production strategy may modulate cells and secretome fingerprints, and for the latter, the effect of serum removal by starvation used in clinical-grade protocols has been underestimated. In this work, the effect of starvation on the molecular profile of interleukin 1 beta (IL1β)-primed adipose-derived MSCs (ASCs) was tested by assessing the expression le
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MacFarlane, R. Bruce, H. Rodger Harvey, Michael J. Bowers, and John S. Patton. "Serum Lipoproteins in Striped Bass (Morone saxatilis): Effects of Starvation." Canadian Journal of Fisheries and Aquatic Sciences 47, no. 4 (1990): 739–45. http://dx.doi.org/10.1139/f90-084.

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Withholding food for 4 wk resulted in more extensive alterations within serum lipoprotein classes in striped bass (Morone saxatilis) than were evident in serum total lipids where only a decrease in triglycerides was significant. Total serum lipoprotein concentrations were about 3300 mg/dL in both fed and starved fish; however, high density lipoproteins (HDL) increased and very low density lipoproteins (VLDL) decreased significantly in the starved group. Quantitatively, the greatest changes in VLDL, the primary transporter of triglycerides, were declines in triglycerides and cholesterol esters.
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Yousif Al-tikrity, Wedyan, and Thaer Mohamed Al-Mashhadani. "Physiological and histological effects of the antioxidant butylated hydroxytoluene (BHT) on white male rats exposed to starvation stress." Science Archives 03, no. 04 (2022): 311–18. http://dx.doi.org/10.47587/sa.2022.3410.

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This study was done to find out the effect of the antioxidant Hydroxytoluene (BHT) on some physiological and histological variables of rats subjected to stress by starvation. 50 kg) starvation + BHT concentration (mg/kg 100) starvation + BHT concentration (50 mg/kg) starvation + olive oil). The data indicate that starvation decreases the sex hormones of rats exposed to stress by starvation Follicle Stimulating Hormone (FSH), Luteinizing Hormone(LH), Testosterone, and damage to testicular tissues, the antioxidant group BHT showed a concentration of (100,50 mg/kg) a protective effect against the
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Wang, Pengtao, Jianhong Xia, Leilei Zhang, et al. "SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis." Cells 8, no. 11 (2019): 1335. http://dx.doi.org/10.3390/cells8111335.

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Centriolar satellites are non-membrane cytoplasmic granules that deliver proteins to centrosome during centrosome biogenesis and ciliogenesis. Centriolar satellites are highly dynamic during cell cycle or ciliogenesis and how they are regulated remains largely unknown. We report here that sorting nexin 17 (SNX17) regulates the homeostasis of a subset of centriolar satellite proteins including PCM1, CEP131, and OFD1 during serum-starvation-induced ciliogenesis. Mechanistically, SNX17 recruits the deubiquitinating enzyme USP9X to antagonize the mindbomb 1 (MIB1)-induced ubiquitination and degrad
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Zhou, Yan Ning, William G. Coleman, Zhaoxu Yang, et al. "Regulation of Cell Growth during Serum Starvation and Bacterial Survival in Macrophages by the Bifunctional Enzyme SpoT in Helicobacter pylori." Journal of Bacteriology 190, no. 24 (2008): 8025–32. http://dx.doi.org/10.1128/jb.01134-08.

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ABSTRACT In Helicobacter pylori the stringent response is mediated solely by spoT. The spoT gene is known to encode (p)ppGpp synthetase activity and is required for H. pylori survival in the stationary phase. However, neither the hydrolase activity of the H. pylori SpoT protein nor the role of SpoT in the regulation of growth during serum starvation and intracellular survival of H. pylori in macrophages has been determined. In this study, we examined the effects of SpoT on these factors. Our results showed that the H. pylori spoT gene encodes a bifunctional enzyme with both a hydrolase activit
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Davidson, Matthew D., and Salman R. Khetani. "Intermittent Starvation Extends the Functional Lifetime of Primary Human Hepatocyte Cultures." Toxicological Sciences 174, no. 2 (2020): 266–77. http://dx.doi.org/10.1093/toxsci/kfaa003.

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Abstract Primary human hepatocyte (PHH) cultures have become indispensable to mitigate the risk of adverse drug reactions in human patients. In contrast to dedifferentiating monocultures, coculture with nonparenchymal cells maintains PHH functions for 2–4 weeks. However, because the functional lifespan of PHHs in vivo is 200–400 days, it is desirable to further prolong PHH functions in vitro toward modeling chronic drug exposure and disease progression. Fasting has benefits on the longevity of organisms and the health of tissues such as the liver. We hypothesized that a culturing protocol that
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Lee, C. K., Bon-sik Koo, C. H. Park, et al. "44 IMPROVED DEVELOPMENT OF BOVINE NUCLEAR TRANSFER EMBRYOS BY THE TREATMENT OF NUCLEAR DONOR CELLS WITH APOPTOSIS INHIBITORS DURING SERUM STARVATION." Reproduction, Fertility and Development 17, no. 2 (2005): 171. http://dx.doi.org/10.1071/rdv17n2ab44.

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In somatic cell nuclear transfer, serum starvation is a widely used method to synchronize donor cells at the quiescent stage (Go) of the cell cycle. However, it has been shown that serum starvation during culture of mammalian cells could induce cell death via apoptosis by removing growth factors and increasing intracellular stress. Therefore, apoptosis caused by serum starvation in somatic cells could induce damages to nuclear DNA contributing to a lower efficiency of nuclear transfer. This study was performed to characterize apoptosis during serum starvation of bovine embryonic fibroblasts (B
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Ming, L., T. Sakaida, W. Yue, A. Jha, L. Zhang, and J. Yu. "Sp1 and p73 activate PUMA following serum starvation." Carcinogenesis 29, no. 10 (2008): 1878–84. http://dx.doi.org/10.1093/carcin/bgn150.

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Oh, Nara, Kyoung Mi Kim, Hana Cho, Junho Choe, and Yoon Ki Kim. "Pioneer round of translation occurs during serum starvation." Biochemical and Biophysical Research Communications 362, no. 1 (2007): 145–51. http://dx.doi.org/10.1016/j.bbrc.2007.07.169.

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Mejia, German. "Serum starvation and stringent response in H. pylori." Biophysical Journal 123, no. 3 (2024): 222a. http://dx.doi.org/10.1016/j.bpj.2023.11.1408.

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Horsburgh, Malcolm J., Michael D. Wiltshire, Howard Crossley, Eileen Ingham, and Simon J. Foster. "PheP, a Putative Amino Acid Permease of Staphylococcus aureus, Contributes to Survival In Vivo and during Starvation." Infection and Immunity 72, no. 5 (2004): 3073–76. http://dx.doi.org/10.1128/iai.72.5.3073-3076.2004.

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ABSTRACT PheP, a putative amino acid permease in Staphylococcus aureus, contributes to starvation survival under glucose-limiting conditions and virulence. A pheP mutation led to poor growth after microaerobic or anaerobic incubation on pig serum agar, which was recovered by phenylalanine addition. Genetic complementation of pheP restored growth and starvation survival.
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Oguchi, Mai E., Koki Okuyama, Yuta Homma, and Mitsunori Fukuda. "A comprehensive analysis of Rab GTPases reveals a role for Rab34 in serum starvation-induced primary ciliogenesis." Journal of Biological Chemistry 295, no. 36 (2020): 12674–85. http://dx.doi.org/10.1074/jbc.ra119.012233.

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Primary cilia are sensors of chemical and mechanical signals in the extracellular environment. The formation of primary cilia (i.e. ciliogenesis) requires dynamic membrane trafficking events, and several Rab small GTPases, key regulators of membrane trafficking, have recently been reported to participate in ciliogenesis. However, the precise mechanisms of Rab-mediated membrane trafficking during ciliogenesis remain largely unknown. In the present study, we used a collection of siRNAs against 62 human Rabs to perform a comprehensive knockdown screening for Rabs that regulate serum starvation-in
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Xie, Min, Shaoming Li, Zhifeng Feng, et al. "Effects of Starvation on the Physiology and Liver Transcriptome of Yellowcheek (Elopichthys bambusa)." Fishes 8, no. 4 (2023): 175. http://dx.doi.org/10.3390/fishes8040175.

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Anthropogenic and extreme climate disasters cause ecological changes in natural rivers and lakes, increasing the risk of starvation in yellowcheek (Elopichthys bambusa). Therefore, the impact of starvation on the metabolism and wild population of yellowcheek should be explored. In this study, we used transcriptome sequencing technology to analyze the effects of short (8 d) and long-term (28 d) starvation on the liver transcriptome, growth, and serum indicators of yellowcheek. Our results showed that short-term starvation significantly reduced the visceral weight and viscera index of yellowchee
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María, Ángeles Esteban*, Espinosa-Ruíz Cristóbal, and Albaladejo-Riad Nora. "Feed Deprivation effects on Bactericidal an Immunological activity of Blood and skin mucus, and on blood Chemistry of Gilthead Seabream (Sparus aurata)." Journal of Agriculture and Aquaculture 2, no. 1 (2020): 1–12. https://doi.org/10.5281/zenodo.3906149.

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Abstract Aquaculture needs to optimize production and nutrition of fish. The effects caused by 1, 2, 4 and 20 days of starvation on humoral immunity and bactericidal activity, against <em>Vibrio anguillarum,</em> in blood and skin mucus of gilthead seabream (<em>Sparus aurata)</em> were determined. In addition, several blood biochemical parameters were also analysed in order to test the general health status of the fish and also in an attempt to correlate the physiological changes due to starvation with the changes observed in the immune parameters. Significant decreases in IgM level and prote
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Takahiko, Kamata, Yohei Mineharu, Yasuzumi Matsui, et al. "10205-TB-8 ABSENCE OF RNF213 IN MEDULLOBLASTOMA INDUCES STARVATION RESISTANCE VIA GAS6 AND RESULTS IN TUMOR PROGRESSION." Neuro-Oncology Advances 5, Supplement_5 (2023): v20. http://dx.doi.org/10.1093/noajnl/vdad141.080.

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Abstract RNF213 gene, initially identified as a disease-causing gene for moyamoya disease, has recently been recognized as a tumor regulator. We investigated the functions of RNF213 in tumorigenicity of medulloblastoma. Knockout of Rnf213 in Ptch1+/- spontaneous medulloblastoma mouse model increased the incidence of SHH type medulloblastoma from 19.8% to 76.5% (p&amp;lt;0.001) at 9 months. Subcutaneous implantation of the tumors showed that depletion of Rnf213 increased tumor formation frequency and tumor size. Unexpectedly, knockout of RNF213 in human Daoy cells decreased tumor growth and inv
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Kiran, Abhimanyu, Chandra Shekhar, Manigandan Sabapathy, et al. "Effect of serum starvation on rheology of cell monolayers." Physics of Fluids 33, no. 7 (2021): 071908. http://dx.doi.org/10.1063/5.0050984.

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42

Matsumura, K., K. Sasaki, T. Tsuji, T. Murakami, M. Takahashi, and F. Shinozaki. "Changes of AgNORs in HeLa cells during serum starvation." British Journal of Cancer 62, no. 3 (1990): 385–87. http://dx.doi.org/10.1038/bjc.1990.303.

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43

Shin, Jordan T., Susan R. Opalenik, John N. Wehby, et al. "Serum-starvation induces the extracellular appearance of FGF-1." Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1312, no. 1 (1996): 27–38. http://dx.doi.org/10.1016/0167-4889(96)00013-4.

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44

Zou, Huawei, Rui Hu, Zhisheng Wang, et al. "Effects of Nutritional Deprivation and Re-Alimentation on the Feed Efficiency, Blood Biochemistry, and Rumen Microflora in Yaks (Bos grunniens)." Animals 9, no. 10 (2019): 807. http://dx.doi.org/10.3390/ani9100807.

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Yak suffers severe starvation and body weight reduction in the cold season and recovers relatively rapid growth in the warm season every year. Herein, we investigated the effects of starvation and refeeding on the growth, feed efficiency, blood biochemistry and rumen microbial community as well as functions of yaks. The results showed that starvation significantly reduced the body weight of yaks. Serum glucose and triglyceride concentrations significantly decreased, and β-hydroxybutyric acid and non-esterified fatty acid levels were significantly increased during the starvation period. Starvat
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DRYNAN, Lesley, Patti A. QUANT, and Victor A. ZAMMIT. "The role of changes in the sensitivity of hepatic mitochondrial overt carnitine palmitoyltransferase in determining the onset of the ketosis of starvation in the rat." Biochemical Journal 318, no. 3 (1996): 767–70. http://dx.doi.org/10.1042/bj3180767.

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The relationships between the increase in blood ketone-body concentrations and several parameters that can potentially influence the rate of hepatic fatty acid oxidation were studied during progressive starvation (up to 24 h) in the rat in order to discover whether the sensitivity of mitochondrial overt carnitine palmitoyltransferase (CPT I) to malonyl-CoA plays an important part in determining the intrahepatic potential for fatty acid oxidation during the onset of ketogenic conditions. A rapid increase in blood ketone-body concentration occurred between 12 and 16 h of starvation, several hour
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Jamali, R., M. Bao, and HJ Arnqvist. "IGF-I but not insulin inhibits apoptosis at a low concentration in vascular smooth muscle cells." Journal of Endocrinology 179, no. 2 (2003): 267–74. http://dx.doi.org/10.1677/joe.0.1790267.

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Apoptosis of vascular smooth muscle cells (VSMCs) is of importance in the development of diabetic angiopathy. Our aim was to evaluate the effect of insulin and IGF-I on apoptosis in VSMCs. Rat aortic VSMCs were used and apoptosis was induced by serum starvation. As apoptotic markers we measured caspase-3 activity, histone-associated DNA fragments by ELISA and nuclear morphology by DAPI (4',6-diamidino-2-phenylindole) staining. Phosphorylation of IGF-I receptors was evaluated by Western blot. Serum starvation had increased caspase-3 activity even after 3 h. The highest activity was found after
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Lin, S. X., K. L. Ferro, and C. A. Collins. "Cytoplasmic dynein undergoes intracellular redistribution concomitant with phosphorylation of the heavy chain in response to serum starvation and okadaic acid." Journal of Cell Biology 127, no. 4 (1994): 1009–19. http://dx.doi.org/10.1083/jcb.127.4.1009.

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Cytoplasmic dynein is a microtubule-binding protein which is considered to serve as a motor for retrograde organelle movement. In cultured fibroblasts, cytoplasmic dynein localizes primarily to lysosomes, membranous organelles whose movement and distribution in the cytoplasm have been shown to be dependent on the integrity of the microtubule cytoskeleton. We have recently identified conditions which lead to an apparent dissociation of dynein from lysosomes in vivo, indicating that alterations in membrane binding may be involved in the regulation of retrograde organelle movement (Lin, S. X. H.,
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Liao, Li-Zhen, Yan-Ling Chen, Li-He Lu, Yong-Hua Zhao, Hua-Lei Guo, and Wei-Kang Wu. "Polysaccharide from Fuzi Likely Protects Against Starvation-Induced Cytotoxicity in H9c2 Cells by Increasing Autophagy Through Activation of the AMPK/mTOR Pathway." American Journal of Chinese Medicine 41, no. 02 (2013): 353–67. http://dx.doi.org/10.1142/s0192415x13500262.

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There is increasing evidence that starvation induces autophagy, which may be protective during starvation, in an AMPK-dependent manner. Polysaccharides from Fuzi (FPS) reportedly have protective effects on nutrition-limited livers. The present study was designed to determine whether FPS protected H9c2 cells against starvation-induced cytotoxicity using an AMPK/mTOR-dependent mechanism. H9c2 cells were incubated in serum and glucose starvation media for 12 hours to establish a cell injury model. 3-Methyladenine (3MA, an autophagy inhibitor) was used to identify the exact role of autophagy in st
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Bergendahl, M., A. Perheentupa, and I. Huhtaniemi. "Effect of short-term starvation on reproductive hormone gene expression, secretion and receptor levels in male rats." Journal of Endocrinology 121, no. 3 (1989): 409–17. http://dx.doi.org/10.1677/joe.0.1210409.

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ABSTRACT The effects of 4–6 days of food deprivation on the pituitary-testicular function of adult male rats were studied. Fasting decreased body weights on average by 23% (P&lt;0·01) and those of seminal vesicles by 55% (P&lt;0·01) in 4 days. No consistent changes were found in testicular and ventral prostate weights. The pituitary levels of gonadotrophin-releasing hormone (GnRH) receptors decreased by 50% (P&lt;0·01). Serum and pituitary levels of LH, FSH and prolactin decreased by 25–50% (P&lt;0·01 for all). Testicular and serum levels of testosterone decreased by 70–80%, testicular LH rece
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Keles, Umur, Evin Iscan, Huriye Erbak Yilmaz, et al. "Differential expression of full-length and NH2 terminally truncated FAM134B isoforms in normal physiology and cancer." American Journal of Physiology-Gastrointestinal and Liver Physiology 319, no. 6 (2020): G733—G747. http://dx.doi.org/10.1152/ajpgi.00094.2020.

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We reported tissues expressing FAM134B-2 such as the kidney, muscle, heart, and pancreas, some of which exhibit stimulated expression upon nutrient starvation. We also demonstrated the effect of Fam134b deletion during ad libitum and starvation conditions. Resistance to weight loss and hypocalcemia, accompanied by an increase in serum albumin and α-amylase levels, indicate critical roles of Fam134b in physiology. Furthermore, the differential expression of FAM134B isoforms was shown to be significantly dysregulated in human cancers.
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