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Journal articles on the topic 'Sesamolin'

Author: Grafiati

Published: 30 May 2022

Last updated: 19 July 2025

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1

Lee, Seung Wook, Tae Soo Kim, Mi-Ja Kim, and Jae Hwan Lee. "Study on the Factors Influencing the Changes of Sesamol and Sesamolin in Sesame Oils during Thermal Oxidation." Food Engineering Progress 15, no. 4 (2011): 420–25. http://dx.doi.org/10.13050/foodengprog.2011.15.4.420.

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Addition effects of free fatty acids (FFA), glycerol, monoacylglycerol (MAG), sesamol, and aqueous extracts of sesame seed meal (ASM) on the changes of sesamol and sesamolin were determined in thermally oxidized sesame oil (SO) at 180°C for 90 min. Sesamol and sesamolin in SO were analyzed by high performance liquid chromatography (HPLC). As the concentration of FFA and MAG in SO increased up to 10% (w/w), the concentration of sesamol increased significantly by 0.94 and 0.70 mM, respectively (p < 0.05) whereas sesamol in control samples increased by 0.09 mM for 90 min oxidation. Sesamolin in 10% MAG and FFA added SO significantly decreased by 15 and 18%, respectively (p < 0.05) compared to control samples. Sesamolin in SO with addition of 1.5 and 2.5 mM sesamol were not significantly different (p > 0.05). Addition effects of ASM on the changes of sesamol and sesamolin in SO were not constant during thermal treatment. Conversion of sesamol from sesamolin in SO during thermal treatment seemed to be influenced by the presence of FFA and MAG.

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2

Rosalina, Reny, and Natthida Weerapreeyakul. "An Insight into Sesamolin: Physicochemical Properties, Pharmacological Activities, and Future Research Prospects." Molecules 26, no. 19 (2021): 5849. http://dx.doi.org/10.3390/molecules26195849.

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Sesame seeds are rich in lignan content and have been well-known for their health benefits. Unlike the other sesame lignan compounds (i.e., sesamin and sesamol), the study of the pharmacological activity of sesamolin has not been explored widely. This review, therefore, summarizes the information related to sesamolin’s pharmacological activities, and the mechanism of action. Moreover, the influence of its physicochemical properties on pharmacological activity is also discussed. Sesamolin possessed neuroprotective activity against hypoxia-induced reactive oxygen species (ROS) and oxidative stress in neuron cells by reducing the ROS and inhibiting apoptosis. In skin cancer, sesamolin exhibited antimelanogenesis by affecting the expression of the melanogenic enzymes. The anticancer activity of sesamolin based on antiproliferation and inhibition of migration was demonstrated in human colon cancer cells. In addition, treatment with sesamolin could stimulate immune cells to enhance the cytolytic activity to kill Burkitt’s lymphoma cells. However, the toxicity and safety of sesamolin have not been reported. And there is also less information on the experimental study in vivo. The limited aqueous solubility of sesamolin becomes the main problem, which affects its pharmacological activity in the in vitro experiment and clinical efficacy. Therefore, solubility enhancement is needed for further investigation and determination of its pharmacological activity profiles. Since there are fewer reports studying this issue, it could become a future prospective research opportunity.

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3

Anna, Belinska, Bochkarev Sergiy, Varankina Oleksandra, et al. "RESEARCH ON OXIDATIVE STABILITY OF PROTEIN-FAT MIXTURE BASED ON SESAME AND FLAX SEEDS FOR USE IN HALVA TECHNOLOGY." Eastern-European Journal of Enterprise Technologies 5, no. 11 (101) (2019): 6–14. https://doi.org/10.15587/1729-4061.2019.178908.

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The analysis of the main methods of modeling the formulations of protein-fat mixtures for special purposes has been conducted. Considerable attention is paid to the choice of methods for stabilizing their lipid component from oxidative damage. The urgency of increasing the oxidative stability of the protein-fat mixtures due to natural antioxidants is emphasized. The feasibility of comprehensive studies of their effect on the stability to oxidation of the most labile biologically active substances of protein-fat mixtures is substantiated. The content of furan antioxidants in the sesame seeds of Ilona, Kadet, Boyarin varieties has been determined. The correlation between the content of free and bound sesamol (sesamolin) has been determined. The content of a-linolenic acid and tocopherols in seeds of Southern Night, Kivik, Sympatik flax varieties has been also investigated. The choice of sesame and flax varieties for the creation of protein-fat mixture for special-purpose, which is a source of w-3 group polyunsaturated fatty acids and antioxidants (sesamol and sesamolin), is justified. The effect of sesamolin content and moisture in the seeds of Ilona variety sesame on the oxidation resistance of its lipid component has been studied. A mathematical dependence describing such effect has been obtained. A regularity of increasing oxidation stability of sesame lipids with increasing its moisture content from 4.0 to 9.5 % has been revealed. This can be explained by sesamolin hydrolysis intensification with the release of sesamol and samin antioxidants. The stabilization effect of a-linolenic acid of flaxseed (Southern Night variety) by free sesame sesamol in the protein-fat mixture for special-purpose has been studied. It has been proved that a rational ratio of w-3 fatty acids and sesamol has a significant effect on the inhibition of lipid oxidation of the protein-fat mixture for special purposes. The content of the protein-fat mixture for special-purpose in sunflower halva at the level of 20 % has been substantiated using a sensory evaluation method. The oxidative stability, organoleptic and physicochemical quality control parameters of the product have been investigated. It has been determined that the oxidation stability (and, accordingly, the predicted shelf life) of model samples of sunflower halva depend on the content of protein-fat mixture in them

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4

Lim, Jin Seon, Yoshikazu Adachi, Yoko Takahashi, and Takashi Ide. "Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats." British Journal of Nutrition 97, no. 1 (2007): 85–95. http://dx.doi.org/10.1017/s0007114507252699.

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Effects of sesamin and sesamolin (sesame lignans) on hepatic fatty acid metabolism were compared in rats. Rats were fed either a lignan-free diet, a diet containing 0·6 or 2 g/kg lignan (sesamin or sesamolin), or a diet containing both sesamin (1·4 g/kg) and sesamolin (0·6 g/kg), for 10 d. Sesamin and sesamolin dose-dependently increased the activity and mRNA abundance of various enzymes involved in hepatic fatty acid oxidation. The increase was much greater with sesamolin than with sesamin. These lignans increased parameters of hepatic fatty acid oxidation in an additive manner when added simultaneously to an experimental diet. In contrast, they decreased the activity and mRNA abundance of hepatic lipogenic enzymes despite dose-dependent effects not being necessarily obvious. Sesamin and sesamolin were equally effective in lowering parameters of lipogenesis. Sesamolin accumulated in serum at 33- and 46-fold the level of sesamin at dietary concentrations of 0·6 and 2 g/kg, respectively. The amount of sesamolin accumulated in liver was 10- and 7-fold that of sesamin at the respective dietary levels. Sesamolin rather than sesamin can account for the potent physiological effect of sesame seeds in increasing hepatic fatty acid oxidation observed previously. Differences in bio-availability may contribute to the divergent effects of sesamin and sesamolin on hepatic fatty acid oxidation. Sesamin compared to sesamolin was more effective in reducing serum and liver lipid levels despite sesamolin more strongly increasing hepatic fatty acid oxidation.

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5

Wan, Yuan, Qiaoyun Zhou, Mengge Zhao, and Tao Hou. "Byproducts of Sesame Oil Extraction: Composition, Function, and Comprehensive Utilization." Foods 12, no. 12 (2023): 2383. http://dx.doi.org/10.3390/foods12122383.

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Sesame is principally used to generate oil, which is produced by chemical refining or pressing. Sesame meal, as a main byproduct of sesame oil extraction, is usually discarded, causing resource waste and economic loss. Sesame meal is rich in sesame protein and three types of sesame lignans (sesamin, sesamolin, and sesamol). Sesame protein extracted via a physical method and an enzymic method has balanced amino acid composition and is an important protein source, and thus it is often added to animal feed and used as a human dietary supplement. Extracted sesame lignan exhibits multiple biological activities such as antihypertensive, anticancer, and cholesterol-lowering activities, and therefore it is used to improve the oxidative stability of oils. This review summarizes the extraction methods, functional activities, and comprehensive utilization of four active substances (sesame protein, sesamin, sesamolin, and sesamol) in sesame meal with the aim to provide theoretical guidance for the maximum utilization of sesame meal.

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6

Yu, Jing, Hao Sun, Yang Yang, and Yaping Yan. "Sesamolin Alleviates Nonalcoholic Fatty Liver Disease through Modulating Gut Microbiota and Metabolites in High-Fat and High-Fructose Diet-Fed Mice." International Journal of Molecular Sciences 23, no. 22 (2022): 13853. http://dx.doi.org/10.3390/ijms232213853.

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Nonalcoholic fatty liver disease (NAFLD) has become a major public health problem. The effects of sesamolin on obesity-associated NAFLD and its possible mechanism are still poorly understood. The present study investigated the effects of sesamolin on NAFLD and changes in gut microbiota and serum metabolites in high-fat and high-fructose (HF-HF) diet-fed mice. Mice with NAFLD were treated with or without sesamolin. Sesamolin effectively suppressed obesity-associated metabolic disorder, attenuated hepatic steatosis and the infiltration of inflammatory cells, and decreased levels of hepatic proinflammatory cytokines. Sesamolin also altered the composition of gut microbiota at the genus level. Additionally, differential serum metabolite biomarkers identified in an untargeted metabolomics analysis showed that sesamolin changed the levels of metabolites and influenced metabolomics pathways including caffeine metabolism, steroid hormone biosynthesis, and cysteine and methionine metabolism. Changes in metabolite biomarkers and the abundances of Faecalibaculum, Lachnoclostridium, Mucispirillum, Allobaculum, and Bacteroides are highly correlated with those factors involved in the progression of NAFLD. These results are important in deciphering new mechanisms by which changes in bacteria and metabolites in sesamolin treatment might be associated with the alleviation of obesity-associated NAFLD in HF-HF diet-fed mice. Thus, sesamolin may be a potential compound for obesity-associated NAFLD treatment.

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7

Baek, Seung-Hwa, Myung-Gyun Kang, and Daeui Park. "Inhibitory Effect of Sesamolin on Melanogenesis in B16F10 Cells Determined by In Vitro and Molecular Docking Analyses." Current Pharmaceutical Biotechnology 21, no. 2 (2020): 169–78. http://dx.doi.org/10.2174/1389201020666191011151123.

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Background: Melanin protects the skin against the harmful effects of ultraviolet irradiation. However, melanin overproduction can result in several aesthetic problems, including melasma, freckles, age spots and chloasma. Therefore, development of anti-melanogenic agents is important for the prevention of serious hyperpigmentation diseases. Sesamolin is a lignan compound isolated from sesame seeds with several beneficial properties, including potential for melanin inhibition. Objective: The aim of this study was to evaluate the anti-melanogenic effect of sesamolin in cell culture in vitro and the underlying mechanism of inhibition using molecular docking simulation. Methods: Melanogenesis was induced by 3-isobutyl-1-methylxanthine in B16F10 melanoma cells, and the inhibitory effects of sesamolin were evaluated using zymography, a tyrosinase inhibitory activity assay, western blotting, and real-time reverse transcription-polymerase chain reaction analysis. Docking simulations between sesamolin and tyrosinase were performed using Autodock vina. Results: Sesamolin significantly inhibited the expression of melanogenesis-related factors tyrosinase, and tyrosinase-related proteins 1 and 2 at the mRNA and protein levels. Treatment of melanoma cells with 50 µM sesamolin demonstrated the strongest inhibition against intercellular tyrosinase and melanin synthesis without exerting cytotoxic effects. Sesamolin significantly reduced mushroom tyrosinase activity in a dose-dependent manner via a competitive inhibition mechanism. Tyrosinase docking simulations supported that sesamolin (-6.5 kcal/mol) bound to the active site of tyrosinase more strongly than the positive control (arbutin, -5.7 kcal/mol). Conclusion: Sesamolin could be developed as a melanogenesis inhibiting agent owing to its dual function in blocking the generation of melanogenesis-related enzymes and inhibiting the enzymatic response of tyrosinase.

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8

Hadeel, S. Y., S. A. Khalida, and Marie Walsh. "Antioxidant activity of sesame seed lignans in sunflower and flaxseed oils." Food Research 4, no. 3 (2019): 612–22. http://dx.doi.org/10.26656/fr.2017.4(3).331.

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This study investigated the antioxidant activity of crude lignan extracts and purified lignans (sesamin, sesamolin, and sesamol) in sunflower and flaxseed oils. Lignan extracts were prepared from roasted sesame seed oil (LRSO) and unroasted sesame seed oil (LUSO). Additionally, the individual lignans were purified from both oils. The crude extracts and purified lignans were added at concentrations of 0.01, 0.02 and 0.03% to the oils and stored at 25 and 65°C over time and peroxide values and thiobarbituric acid values were measured. Each oil showed an increase in oxidation over time, with the samples stored at 65°C exhibiting accelerated oxidation. In general, LRSO showed higher antioxidant activity than LUSO and the antioxidant activity was similar to the antioxidant activity of butylated hydroxytoluene (0.02% BHT) in both oils when used at concentrations of 0.02 and 0.03%. Sesamol showed the highest antioxidant activity of each of the purified lignans followed by sesamin and sesamolin respectively. Crude and purified sesame lignans may have potential applications as natural antioxidants in food systems

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9

Tzen, Jason T. C., Fu-Chou Cheng, Tzyy-Rong Jinn, and Rolis C. W. Hou. "Neuroprotective Effects of Sesamin and Sesamolin on Gerbil Brain in Cerebral Ischemia." International Journal of Biomedical Science 2, no. 3 (2006): 284–88. http://dx.doi.org/10.59566/ijbs.2006.2284.

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Sesamin and sesamolin, abundant lignans found in sesame oil, have been demonstrated to possess several bioactivities beneficial for human health. Excess generation of nitric oxide in lipopolysaccharide-stimulated rat primary microglia cells was significantly attenuated when they were pretreated with sesamin or sesamolin. The neuroprotective effect of sesamin and sesamolin was also observed in vivo using gerbils subjected to a focal cerebral ischemia induced by occlusion of the right common carotid artery and the right middle cerebral artery. Repeated treatment of sesamin or a crude sesame oil extract containing both sesamin and sesamolin significantly reduced the infarct size, visualized via 2,3,5-triphenyltetrazolium chloride staining, by approximately 50% when compared with the control group. These results suggest that sesamin and sesamolin exert effective neuroprotection against cerbral ischemia.

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10

Xu, Fangtao, Rong Zhou, Senouwa Segla Koffi Dossou, Shengnan Song, and Linhai Wang. "Fine Mapping of a Major Pleiotropic QTL Associated with Sesamin and Sesamolin Variation in Sesame (Sesamum indicum L.)." Plants 10, no. 7 (2021): 1343. http://dx.doi.org/10.3390/plants10071343.

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Deciphering the genetic basis of quantitative agronomic traits is a prerequisite for their improvement. Herein, we identified loci governing the main sesame lignans, sesamin and sesamolin variation in a recombinant inbred lines (RILs, F8) population under two environments. The content of the two lignans in the seeds was investigated by HPLC. The sesamin and sesamolin contents ranged from 0.33 to 7.52 mg/g and 0.36 to 2.70 mg/g, respectively. In total, we revealed 26 QTLs on a linkage map comprising 424 SSR markers, including 16 and 10 loci associated with sesamin and sesamolin variation, respectively. Among them, qSmin_11.1 and qSmol_11.1 detected in both the two environments explained 67.69% and 46.05% of the phenotypic variation of sesamin and sesamolin, respectively. Notably, qSmin11-1 and qSmol11-1 were located in the same interval of 127-127.21cM on LG11 between markers ZMM1776 and ZM918 and acted as a pleiotropic locus. Furthermore, two potential candidate genes (SIN_1005755 and SIN_1005756) at the same locus were identified based on comparative transcriptome analysis. Our results suggest the existence of a single gene of large effect that controls expression, both of sesamin and sesamolin, and provide genetic information for further investigation of the regulation of lignan biosynthesis in sesame.

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11

Matsumura, Shinichi, Kazuya Murata, Nobuhiro Zaima та ін. "Inhibitory Activities of Sesame Seed Extract and its Constituents against β-Secretase". Natural Product Communications 11, № 11 (2016): 1934578X1601101. http://dx.doi.org/10.1177/1934578x1601101112.

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The need for a preventive agent against dementia led us to screen natural plant resources. Among the herbs and spices tested, sesame seed prepared from Sesamum indicum seeds showed potent β-secretase inhibitory activity. The active principles were determined to be sesamin and sesamolin, typical lignans in S. indicum. The IC50 values of sesamin and sesamolin were 257 and 140 μM, respectively. These compounds were investigated in a preliminary absorption experiment. After oral administration, these compounds were detected in an intact form in the brain and serum. These results suggest that consumption of sesame seeds may prevent dementia by sesamin and sesamolin, the constituents in sesame seeds.

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12

Junhom, C., B. Siriwarin, N. Weerapreeyakul, and S. Barusrux. "210: Effect of sesamin, sesamolin and sesamol on P-glycoprotein mediated efflux." European Journal of Cancer 50 (July 2014): S48. http://dx.doi.org/10.1016/s0959-8049(14)50181-5.

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13

Srisayam, Montra, Natthida Weerapreeyakul, and Kwanjai Kanokmedhakul. "Inhibition of two stages of melanin synthesis by sesamol, sesamin and sesamolin." Asian Pacific Journal of Tropical Biomedicine 7, no. 10 (2017): 886–95. http://dx.doi.org/10.1016/j.apjtb.2017.09.013.

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14

Hofer, Otmar, Gerda Lutz, Günter Brader, and Christoph Kratky. "Conformational Analysis of Tetrahydrofurofuran Lignans: Sesamolin." HETEROCYCLES 45, no. 2 (1997): 287. http://dx.doi.org/10.3987/com-96-7651.

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15

Jeng, K., and R. Hou. "Sesamin and Sesamolin: Natures Therapeutic Lignans." Current Enzyme Inhibition 1, no. 1 (2005): 11–20. http://dx.doi.org/10.2174/1573408052952748.

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16

Salamah, Nina. "Identify the Purity of Sesame Oil from Sesame Seeds (Sesamum indicum L.) and Analysis Using the ATR-FTIR Method." Indonesian Journal of Pharmaceutical Science and Technology 11, no. 3 (2024): 382–92. http://dx.doi.org/10.24198/ijpst.v11i3.50102.

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Sesame seeds (Sesamum indicum L.) are a plant that produces the most important and oldest oil known to man. Apart from being rich in nutrients, sesame consists of important functional components such as sesamin, sesamolin, sesamol, sesaminol, sesamolin phenol, and other lignan-like active ingredients and can trigger the motive to produce sesame oil by adulteration in order to achieve market desires. The aim of this research is to identify the purity of sesame oil and analyze it using the ATR-FTIR method to detect and prevent counterfeiting. Testing the characteristics of sesame oil can be adjusted to the quality requirements that have been set, one of which is the Indonesian National Standard (SNI) so that the quality of sesame oil circulating on the market is guaranteed. This research is non-experimental research. Sesame seed oil resulting from pressing is based on the test requirements of SNI 01-4468-1998 including the physico-chemical properties test. The results of the sesame seed oil profile are that the sesame seed oil extraction yield is 29.265%, the sesame oil is bright yellow in color, has a distinctive smell, specific gravity (20oC) 0.9237± 0.0057, refractive index 1.4702 ± 0.0005, peroxide value 2 ± 0.0577 meqO2/Kg, iodine value 107.1 ± 0.5773, and acid number 0.224 ± 0.0577. Based on the research results, it can be concluded that the pressed sesame seed oil has met the requirements of the SNI 01-4468-1998 test, and from the functional groups that appear in the ATR-FTIR it can be concluded that the pressed sesame oil contains methyl ester group compounds.

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17

Shah, Hayder Ali, Ajay Kumar Tikoo, and Sabiha Khan. "Phytochemical and Ethnopharmacological Review of Till Safeed (Sesamum indicum Linn.)." Journal of Drug Delivery and Therapeutics 14, no. 9 (2024): 223–31. http://dx.doi.org/10.22270/jddt.v14i9.6803.

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Within the management of health care, the traditional system of medicine remains indispensable. The Unani system of medicine treats a variety of illnesses with a range of medications derived from plants. Historically, people have utilized sesamum indicum seeds as a medicinal ingredient. Various parts of the plant have been used by traditional physicians. However, the dried seed and oil are commonly used as Till in Unani Medicine. The plant has a very long history of use as a medicinal herb. It can be used on its own or in compound pharmacopeial compositions with other medications. Till Safeed is an annual plant of family Pedaliaceae and this review article aims to describe morphological characteristics, phytochemistry, ethnobotanical uses and therapeutic properties of Till Safeed. So that subsequent study on any novel therapeutic activity based on phytochemistry can be conducted with greater simplicity and to support the revalidation of the drug's scientifically claimed actions as mentioned in classical literatures. We systematically searched classical Unani literature, online data sources (PubMed, Google scholar, Elsevier, Science Direct and Research Gate) and offline encyclopaedia and books on medicinal plants for the relevant data on Till Safeed. Polyunsaturated fatty acids, phytosterols, tocopherols, essential minerals, and a special class of phenylpropanoid chemicals called lignans—which include sesamin, sesamol, and sesamolin—are among the bioactive ingredients found in till seeds. The pharmacological characteristics of sesame lignans include. Antioxidant, antibacterial, antiproliferative, cholesterol-lowering, hepatic fatty acid oxidation enzyme-increasing, and anti-hypertensive properties. Keywords: Sesamum indicum, Unani Medicine, phytochemistry, sesamin, sesamolin.

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18

Kurt, Cemal. "Susamın (Sesamum indicum) Sağlık Üzerine Bazı Etkileri." Turkish Journal of Agriculture - Food Science and Technology 12, no. 7 (2024): 1231–37. http://dx.doi.org/10.24925/turjaf.v12i7.1231-1237.6241.

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Zengin bir protein kaynağı olan susam, yağ elde etmek amacıyla yetiştirilen ilk bitkilerden biridir ve dünyanın birçok ülkesinde tarih öncesi çağlardan beri kültürü yapılmaktadır. Susam tohumları yüksek oranda içerdiği yağ asitlerinin (ortalama %80) doymamış yanı sıra insan sağlığı için önemli faydaları olan sesamol ve sesamolin gibi antioksidanları da içermektedir. Ayrıca tohumları önemli bir Ca, Mg ve Se kaynağıdır. Son yıllarda yapılan çalışmalar, susam tohumları ve yağının insan beslenmesi için yüksek enerji kaynağı olmasının yanı sıra insan sağlığı açısından da anti-aging, antikanserojen, antiinflammatuar, antifungal, antimikrobiyal etkilerinin olduğu, karaciğerde alkol ayrışmasını hızlandırdığı, antihipertansif aktivite ve immün düzenleyici aktivitelere de sahip olduğunu göstermiştir. Özellikle siyah susam yağının saç beyazlamasını önlediği de yapılan çalışmalar sonucunda tespit edilmiştir. Ayrıca, susam bitkisinin farklı kısımlarının özellikle dizanteri gibi hastalıkların tedavisinde uzun yıllardan beri kullanıldığı da bilinmektedir.

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19

Bedigian, Dorothea, David S. Seigler, and Jack R. Harlan. "Sesamin, sesamolin and the origin of sesame." Biochemical Systematics and Ecology 13, no. 2 (1985): 133–39. http://dx.doi.org/10.1016/0305-1978(85)90071-7.

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20

Liu, Ling-shuai, Yu-meng Yu, Chen-xia Zhang, et al. "Acid-catalyzed conversion of sesamolin to sesamol: Kinetics and reaction mechanism based on density functional theory." Food Chemistry 472 (April 2025): 142972. https://doi.org/10.1016/j.foodchem.2025.142972.

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21

Andargie, Mebeaselassie, Maria Vinas, Anna Rathgeb, Evelyn Möller, and Petr Karlovsky. "Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review." Molecules 26, no. 4 (2021): 883. http://dx.doi.org/10.3390/molecules26040883.

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Major lignans of sesame sesamin and sesamolin are benzodioxol--substituted furofurans. Sesamol, sesaminol, its epimers, and episesamin are transformation products found in processed products. Synthetic routes to all lignans are known but only sesamol is synthesized industrially. Biosynthesis of furofuran lignans begins with the dimerization of coniferyl alcohol, followed by the formation of dioxoles, oxidation, and glycosylation. Most genes of the lignan pathway in sesame have been identified but the inheritance of lignan content is poorly understood. Health-promoting properties make lignans attractive components of functional food. Lignans enhance the efficiency of insecticides and possess antifeedant activity, but their biological function in plants remains hypothetical. In this work, extensive literature including historical texts is reviewed, controversial issues are critically examined, and errors perpetuated in literature are corrected. The following aspects are covered: chemical properties and transformations of lignans; analysis, purification, and total synthesis; occurrence in Seseamum indicum and related plants; biosynthesis and genetics; biological activities; health-promoting properties; and biological functions. Finally, the improvement of lignan content in sesame seeds by breeding and biotechnology and the potential of hairy roots for manufacturing lignans in vitro are outlined.

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LUTZ, G., O. HOFER, G. BRADER, and C. KRATKY. "ChemInform Abstract: Conformational Analysis of Tetrahydrofurofuran Lignans: Sesamolin." ChemInform 28, no. 34 (2010): no. http://dx.doi.org/10.1002/chin.199734276.

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23

Wu, Ming-Shun, Levent Bless B. Aquino, Marjette Ylreb U. Barbaza, et al. "Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review." Molecules 24, no. 24 (2019): 4426. http://dx.doi.org/10.3390/molecules24244426.

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The use of foodstuff as natural medicines has already been established through studies demonstrating the pharmacological activities that they exhibit. Knowing the nutritional and pharmacological significance of foods enables the understanding of their role against several diseases. Among the foods that can potentially be considered as medicine, is sesame or Sesamum indicum L., which is part of the Pedaliaceae family and is composed of its lignans such as sesamin, sesamol, sesaminol and sesamolin. Its lignans have been widely studied and are known to possess antiaging, anticancer, antidiabetes, anti-inflammatory and antioxidant properties. Modern chronic diseases, which can transform into clinical diseases, are potential targets of these lignans. The prime example of chronic diseases is rheumatic inflammatory diseases, which affect the support structures and the organs of the body and can also develop into malignancies. In line with this, studies emphasizing the anti-inflammatory and anticancer activities of sesame have been discussed in this review.

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Bożek, Małgorzata, Julia Trybała, Agata Lebiedowska, Anna Stolecka-Warzecha, Paula Babczyńska, and Sławomir Wilczyński. "Assessment of the Sunscreen Properties of Sesame Oil Using the Hemispherical Directional Reflectance Method." Applied Sciences 14, no. 15 (2024): 6545. http://dx.doi.org/10.3390/app14156545.

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Sesame oil has been widely used for centuries. It is not only used as a kitchen ingredient, but it is also used to apply to the skin. Sesame oil contains natural compounds such as sesamol, sesamolin and sesamide, which have the ability to reflect or absorb certain UV rays. These substances can act as UV filters, helping to minimize the effects of harmful UV radiation on the skin. The aim of the study was to investigate the radioprotective/sun protection properties of sesame oil. The influence of sesame oils from different manufacturers on the directional reflectance of the skin was analyzed at various time intervals. To assess the sunscreen properties of the oil, a new technique was used: the 410-Solar hemispherical directional reflectometer. Sesame oil can be used in sunscreen preparations, but only when combined with other, more powerful ingredients. The oil itself is not sufficient protection against solar radiation. The study revealed no significant disparities in performance between the tested sesame oils from diverse manufacturers.

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Kitipaspallop, Wannakarn, Siwapech Sillapaprayoon, Preecha Phuwapraisirisan, Woo-Keun Kim, Chanpen Chanchao, and Wittaya Pimtong. "Developmental effects of sesamolin on zebrafish (Danio rerio) embryos." Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 256 (June 2022): 109319. http://dx.doi.org/10.1016/j.cbpc.2022.109319.

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Kang, Myung-Hwa, Michitaka Naito, Nobuko Tsujihara, and Toshihiko Osawa. "Sesamolin Inhibits Lipid Peroxidation in Rat Liver and Kidney." Journal of Nutrition 128, no. 6 (1998): 1018–22. http://dx.doi.org/10.1093/jn/128.6.1018.

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Srisongkram, Tarapong, and Natthida Weerapreeyakul. "Route of intracellular uptake and cytotoxicity of sesamol, sesamin, and sesamolin in human melanoma SK-MEL-2 cells." Biomedicine & Pharmacotherapy 146 (February 2022): 112528. http://dx.doi.org/10.1016/j.biopha.2021.112528.

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Lee, Jinyoung, Yoosung Lee, and Eunok Choe. "Effects of sesamol, sesamin, and sesamolin extracted from roasted sesame oil on the thermal oxidation of methyl linoleate." LWT - Food Science and Technology 41, no. 10 (2008): 1871–75. http://dx.doi.org/10.1016/j.lwt.2007.11.019.

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Shin, Bo Ram, Seung-Ok Yang, Hye-Won Song, Myung-Sub Chung, and Young-Suk Kim. "Effects of adsorbents on benzo(a)pyrene, sesamol, and sesamolin contents and volatile component profiles in sesame oil." Food Science and Biotechnology 24, no. 6 (2015): 2017–22. http://dx.doi.org/10.1007/s10068-015-0266-x.

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30

Yuenyong, Jitkunya, Suchintana Limkoey, Chonlathit Phuksuk, et al. "Enhancing Functional Compounds in Sesame Oil through Acid-Soaking and Microwave-Heating of Sesame Seeds." Foods 13, no. 18 (2024): 2891. http://dx.doi.org/10.3390/foods13182891.

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This study investigated whether pre-treating sesame (Sesamum indicum L.) seeds with a combination of acid-soaking and microwave-heating could significantly enhance the quality of the resulting sesame oil, particularly by increasing its content of functional compounds such as lignans, tocopherol, phytosterol, and squalene. The study revealed that soaking the sesame seeds in a solution of HCl and citric acid, along with microwave-heating, significantly increased the content of these compounds. The detected ranges were sesamin (1365–6927 µg g−1), sesamolin (605–3493 µg g−1), tocopherol (69.31–282.76 µg g−1), asarinin (ND–383.52 µg g−1), sesamol (ND–49.59 µg g−1), phytosterol (3690–6201 µg g−1), and squalene (532−1628 µg g−1). Additionally, the study found that the pre-treatment of sesame seeds had a minimal effect on the fatty acid composition, antioxidant activity (92.94–95.08% DPPH scavenging activity), and oxidative stability (2.13–2.90 mg MDA kg−1 oil). This is the first study to demonstrate that using acid-soaking and microwave-heating to prepare sesame seeds can produce sesame oil enriched with functional compounds, potentially benefiting cosmetic, pharmaceutical, and health applications.

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Chantzos, Nickolaos, and Constantinos Georgiou. "Monitoring lipid oxidation events at frying temperatures through radical scavenging assays." Chemical Industry and Chemical Engineering Quarterly 13, no. 3 (2007): 163–66. http://dx.doi.org/10.2298/ciceq0703163c.

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This communication proposes an alternative approach for monitoring oils during thermal stress at frying temperatures through radical scavenging assays. Oxidation events for extra virgin olive, pomace, sesame, sunflower, soybean, corn and of a commercial blend of oils are followed through the DPPH assay during heating at 100, 150 and 190?C. Radical scavenging activity decrease expressed as trolox equivalent antioxidant capacity (?TEAC, mmol trolox kg-1 oil) is found to be linearly related to increases in total oxidation (?TOTOX) values. This relationship is valid down to a certain - ?TEAC value cutoff that is different for different oils. Considerable consumption of antioxidants demonstrated by high -?TEAC values renders the linear relationship invalid indicating that antioxidants cannot control late events of oxidative damage. Radical scavenging activity is found to increase upon sesame oil heating in contrast to all other oils. It is postulated that sesamolin, a phenolic antioxidant, decomposes during heating to the more potent antioxidant sesamol accounting for the increase of radical scavenging activity upon heating. This paper demonstrates prospects of radical scavenging activity assays as a tool for monitoring oxidation events during frying and warrants further research and evaluation.

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Kandalkar, Ankita, Anushka Dinesh, and Sagar Nagare. "Identification of Potent Natural Inhibitor Against Papain Like Protease of SARS CoV 2 an in Silico Approach." Defence Life Science Journal 8, no. 1 (2023): 41–49. http://dx.doi.org/10.14429/dlsj.8.17831.

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One of the most complicated tasks the healthcare system has faced in recent years has been the development of a curative treatment to stop the progression of the SARS CoV-2 virus. No consensus has been reached on a medical cure to slow the virus spread. From this point of view, investigating existing drugs such as SARS-CoV-2 inhibitors is an appropriate technique. With critical involvement in viral replication and host-immune suppression, Papain-like protease (PL-pro) is recognized as a key enzyme target for drug development among other SARS-CoV-2 druggable targets. Phytolignans have a wide range of physiological effects, making them an appealing drug for antiviral study. We used an insilico method to target SARS CoV-2 PL-pro with phytolignans in our investigation. The chemical structures of phytolignans were obtained from PubChem, whereas the protease structure 6WX4was obtained from the Protein Data Bank website. The PyRx software was used for molecular docking.Of all the phytolignans examined, Sesamolin has the greatest binding affinity of -8.4 kcal/mol towards PL-pro.The docking results revealed that phytolignans are potent inhibitors of the SARS-CoV-2 papain-like protease and that they may be verified further in vitro and in vivo. Our findings suggest that Sesamolin might be used as a medication to block the action of SARS CoV-2 PL-pro.

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Kim, A.-Young, Choong-In Yun, Joon-Goo Lee, and Young-Jun Kim. "Determination and Daily Intake Estimation of Lignans in Sesame Seeds and Sesame Oil Products in Korea." Foods 9, no. 4 (2020): 394. http://dx.doi.org/10.3390/foods9040394.

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Sesame (Sesamum indicum L.) is a plant that belongs to the Pedaliaceae family which was first classified as a food source around 4000 years ago. Lignans (sesamin, sesamolin, sesamol, and sesaminol) present in sesame are the primary functional compounds that impart important health benefits. However, very little information is available on the lignan intake from sesame seeds and sesame oil products. Sesame oil is frequently and highly consumed in Korea and therefore is one of the important lignan intake sources due to the food eating habits of Koreans. Herein, we studied the distribution of lignans in sesame seeds (n = 21) and oil (n = 34) to estimate the daily lignan intake by the Korean population. High-performance liquid chromatography, in conjunction with statistical analysis, was used to determine the lignan content of seeds and oil. The estimated daily intake of total lignans from sesame seeds and oil, as estimated from the available domestic consumption data (Korea Nutrition and Health Examination Survey), is 18.39 mg/person/day for males and 13.26 mg/person/day for females. The contributions of lignan intake from sesame seeds and oil are 23.0% and 77.0%, respectively. This study provides preliminary information on lignan intake from sesame seeds and oil in the Korean population.

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34

Muangrat, Rattana, Yongyut Chalermchart, Supachet Pannasai, and Sukhuntha Osiriphun. "Effect of Roasting and Vacuum Microwave Treatments on Physicochemical and Antioxidant Properties of Oil Extracted from Black Sesame Seeds." Current Research in Nutrition and Food Science Journal 8, no. 3 (2020): 798–814. http://dx.doi.org/10.12944/crnfsj.8.3.12.

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Unroasted, roasted (at roasting temperatures of 100, 150 and 200 C and roasting times of 10, 20 and 30 min) and vacuum microwaved (at microwave watt powers of 800, 1440, 2400 and 3600 watts/kg black sesame seeds, for heating times of 10, 20 and 30 min) black sesame seeds were processed to extract oil using a single screw press at a constant pressing temperature of 50 C. The results revealed that different heat pre-treatments significantly affected yield and physiochemical and antioxidant properties of extracted oils. The extracted oil samples exhibited significantly different levels of total phenolic compounds, sesamin, sesamolin, and DPPH• and ABTS•+ scavenging activity. Additionally, it was found that these values of roasted and vacuum microwaved black sesame seed oils were significantly higher than those of unroasted oil. Sesamin, sesamolin, total content of phenolic compounds, and DPPH• and ABTS•+ scavenging activity of extracted black sesame oils increased when the roasting temperature and watt power increased. Black sesame oil obtained from unroasted, roasted and vacuum microwaved dried black sesame seeds contained linoleic and oleic acids as major fatty acids. Black sesame oil extracted from roasting and vacuum microwave treatments for 10 min at higher roasting temperature and microwave watt power had higher total phenolic content leading to a reduction of peroxide value and elevated stability of soybean oil when it was added during storage time at temperature of 65 °C.

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NAGATA, Masayasu, Toshihiko OSAWA, Mitsuo NAMIKI, Yasuko FUKUDA, and Tatsuhiko OZAKI. "Stereochemical structures of antioxidative bisepoxylignans, sesaminol and its isomers, transformed from sesamolin." Agricultural and Biological Chemistry 51, no. 5 (1987): 1285–89. http://dx.doi.org/10.1271/bbb1961.51.1285.

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36

Nagata, Masayasu, Toshihiko Osawa, Mitsuo Namiki, Yasuko Fukuda, and Tatsuhiko Ozaki. "Stereochemical Structures of Antioxidative Bisepoxylignans, Sesaminol and Its Isomers, Transformed from Sesamolin." Agricultural and Biological Chemistry 51, no. 5 (1987): 1285–89. http://dx.doi.org/10.1080/00021369.1987.10868187.

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37

Liang, Ming-Tsai, Ru-Chien Liang, Li-Rong Huang, Ping-Hsuan Hsu, Yu-Hsuan Wu, and Hung-En Yen. "Separation of Sesamin and Sesamolin by a Supercritical Fluid-Simulated Moving Bed." American Journal of Analytical Chemistry 03, no. 12 (2012): 931–38. http://dx.doi.org/10.4236/ajac.2012.312a123.

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38

Keowkase, Roongpetch, Natthawut Shoomarom, Worawee Bunargin, Worapan Sitthithaworn та Natthida Weerapreeyakul. "Sesamin and sesamolin reduce amyloid-β toxicity in a transgenic Caenorhabditis elegans". Biomedicine & Pharmacotherapy 107 (листопад 2018): 656–64. http://dx.doi.org/10.1016/j.biopha.2018.08.037.

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39

Hou, Rolis Chien-Wei, Hsueh-Meei Huang, Jason T. C. Tzen, and Kee-Ching G. Jeng. "Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells." Journal of Neuroscience Research 74, no. 1 (2003): 123–33. http://dx.doi.org/10.1002/jnr.10749.

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40

Huang, Jinian, Guohui Song, Lixia Zhang, Qiang Sun, and Xin Lu. "A novel conversion of sesamolin to sesaminol by acidic cation exchange resin." European Journal of Lipid Science and Technology 114, no. 7 (2012): 842–48. http://dx.doi.org/10.1002/ejlt.201100247.

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41

Jan, Kuo-Ching, and Mohsen Gavahian. "Sustainable Supercritical Carbon Dioxide Extraction of Value-Added Lignan from Sesame Meal: Achieving Green Neuroprotection and Waste Valorization by Optimizing Temperature, Solvent, and Pressure." Molecules 30, no. 3 (2025): 539. https://doi.org/10.3390/molecules30030539.

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In pursuing sustainable health solutions and growing demand for neuroprotective interventions, the industry demands alternative green extraction technologies to valorize agri-food by-products. This study aimed to develop an optimized supercritical carbon dioxide extraction to isolate sesame meal’s functional compound (lignans) and assess their neuroprotective effects. Extraction was performed at various pressures (2–4 kpsi), temperatures (40–60 °C), co-solvent concentrations (2–25 mol% ethanol), and CO2 collection segments (0–100 NL) to systematically analyze extraction parameters. Extracts were analyzed quantitatively using high-performance liquid chromatography followed by neuroprotective mechanisms analysis through PC12 neural cell and ischemic stroke models. The results showed that adding ethanol enhanced the polarity and density of supercritical CO2, improving the extraction efficiency of polar lignans. Optimal extraction conditions (4 kpsi, 50 °C, 10 mol% ethanol) yielded the highest sesamol, sesamin, and sesamolin. Extracts showed remarkable protective capabilities when subjected to oxygen–glucose deprivation (OGD) conditions simulating ischemic stress, preventing the enhancement of lactate dehydrogenase activity. Relatively low extract concentrations (25–100 μg/mL) significantly mitigated cellular damage induced by short and extended OGD conditions. The findings revealed green extraction methodologies’ capability to transform sesame meal, a food processing waste, into value-added compounds, in line with sustainable development goals for responsible and sustainable food production, particularly SDGs 3, 9, 12, and 13.

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42

Shin, Bo Ram, Hye-Won Song, Joon-Goo Lee, Hae-Jung Yoon, Myung-Sub Chung, and Young-Suk Kim. "Comparison of the contents of benzo(a)pyrene, sesamol and sesamolin, and volatiles in sesame oils according to origins of sesame seeds." Applied Biological Chemistry 59, no. 1 (2016): 129–41. http://dx.doi.org/10.1007/s13765-015-0138-3.

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43

Takahashi, Miki, Yuzo Nishizaki, Koji Morimoto, Naoki Sugimoto, Kyoko Sato, and Koichi Inoue. "Design of synthetic single reference standards for the simultaneous determination of sesamin, sesamolin, episesamin, and sesamol by HPLC using relative molar sensitivity." Separation Science Plus 1, no. 7 (2018): 498–505. http://dx.doi.org/10.1002/sscp.201800081.

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44

OZAYDİN, Dilan, and Pınar KURU BEKTAŞOĞLU. "Travmatik Beyin Hasarı Sıçan Modelinde Sesamol’ün İkincil Yaralanmaya Karşı Koruyucu Etkileri." Kırıkkale Üniversitesi Tıp Fakültesi Dergisi 25, no. 1 (2023): 136–42. http://dx.doi.org/10.24938/kutfd.1262700.

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Amaç: Sesamol güçlü bir antioksidan, antiinflammatuar, antiapoptotik ve nöroprotektif bir kimyasaldır. Bu çalışmada, sesamolün sıçan travmatik beyin hasarı (TBH) modelinde histopatolojik etkilerinin araştırılması amaçlanmıştır.  Gereç ve Yöntemler: Otuz iki erkek sıçan dört gruba ayrıldı: kontrol, travma, sham ve sesamol. Travma, sham ve sesamol gruplarına ağırlık düşme yöntemi ile kapalı kafa travması uygulandı, travmadan hemen sonra sırasıyla sham ve sesamol gruplarına periton içine salin ve sesamol (100 mg/kg) uygulandı. Travmadan 24 saat sonra, beyin örnekleri alındı ve elektron ve ışık mikroskobu kullanılarak beyin korteksi histomorfolojik olarak incelendi.  Bulgular: Histopatolojik değerlendirme sonucunda sesamol grubunda kafa travması ile indüklenen beyin korteksindeki hasar travma ve sham gruplarından daha azdı. Travma grubuna göre sesamol grubunda perivasküler alan ödemi daha azdı. Sesamol grubunun nöronal uzantılarında da daha az hücre içi ödem ve vakuoller izlendi.  Sonuç: Bu çalışmanın sonuçları sesamolün TBH'na karşı nöroprotektif etkiler gösterdiğini ortaya koymuştur.

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Fukuda, Yasuko, Minoru Isobe, Masayasu Nagata, Toshihiko Owaea, and Mitsuo Namiki. "Acidic Transformation of Sesamolin, the Sesami-oil Constituent, into an Antioxidant Bisepoxylignan, Sesaminol." HETEROCYCLES 24, no. 4 (1986): 923. http://dx.doi.org/10.3987/r-1986-04-0923.

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Tsai, Hsin-Ya, Wei-Ju Lee, I.-Hsuan Chu, Wei-Ching Hung, and Nan-Wei Su. "Formation of Samin Diastereomers by Acid-Catalyzed Transformation of Sesamolin with Hydrogen Peroxide." Journal of Agricultural and Food Chemistry 68, no. 23 (2020): 6430–38. http://dx.doi.org/10.1021/acs.jafc.0c01616.

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AMAROWICZ, R., F. SHAHIDI, and R. B. PEGG. "APPLICATION OF SEMIPREPARATIVE RP-18 HPLC FOR THE PURIFICATION OF SESAMIN AND SESAMOLIN." Journal of Food Lipids 8, no. 2 (2001): 85–94. http://dx.doi.org/10.1111/j.1745-4522.2001.tb00186.x.

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Lee, Jae Kwon. "Sesamolin promotes cytolysis and migration activity of natural killer cells via dendritic cells." Archives of Pharmacal Research 43, no. 4 (2020): 462–74. http://dx.doi.org/10.1007/s12272-020-01229-y.

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Dehkordi, Farshad Roghani, and Mehrdad Roghani. "Mechanisms Underlying Sesamolin-Induced Attenuation of Vascular Dysfunction in Rats With Streptozotocin-Induced Diabetes." International Journal of Endocrinology & Metabolism 9, no. 2 (2012): 311–16. http://dx.doi.org/10.5812/kowsar.1726913x.2380.

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FUKUDA, Yasuko, Toshihiko OSAWA, Shunro KAWAGISHI, and Mitsuo NAMIKI. "Comparison of contents of sesamolin and lignan antioxidants in sesame seeds cultivated in Japan." NIPPON SHOKUHIN KOGYO GAKKAISHI 35, no. 7 (1988): 483–86. http://dx.doi.org/10.3136/nskkk1962.35.7_483.

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