Log in

Relevant bibliographies by topics / Severe Actute Respiratory Syndrome (SARS) / Journal articles

To see the other types of publications on this topic, follow the link: Severe Actute Respiratory Syndrome (SARS).

Journal articles on the topic 'Severe Actute Respiratory Syndrome (SARS)'

Author: Grafiati

Published: 29 July 2024

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Severe Actute Respiratory Syndrome (SARS).'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Fielding, James E., Keflemar Yohannes, Hassan Vally, and Jenean D. Spencer. "Severe acute respiratory syndrome surveillance in Australia." Communicable Diseases Intelligence 28 (June 30, 2004): 181–86. https://doi.org/10.33321/cdi.2004.28.15.

Full text

Abstract:

In March 2003, the World Health Organization (WHO) issued a global alert recommending active worldwide surveillance for severe acute respiratory syndrome (SARS). This paper describes the epidemiological features of cases reported by Australian states and territories to the Australian Government Department of Health and Ageing between 17 March and 31 July 2003. There were 138 people investigated for SARS: 111 as suspect and 27 as probable. Five probable cases were reported to WHO after review of other possible diagnoses and Australia-specific exclusion criteria had been applied. An additional p

APA, Harvard, Vancouver, ISO, and other styles

2

Ivanov, Konstantin A., Volker Thiel, Jessika C. Dobbe, Yvonne van der Meer, Eric J. Snijder, and John Ziebuhr. "Multiple Enzymatic Activities Associated with Severe Acute Respiratory Syndrome Coronavirus Helicase." Journal of Virology 78, no. 11 (2004): 5619–32. http://dx.doi.org/10.1128/jvi.78.11.5619-5632.2004.

Full text

Abstract:

ABSTRACT Severe acute respiratory syndrome coronavirus (SARS-CoV), a newly identified group 2 coronavirus, is the causative agent of severe acute respiratory syndrome, a life-threatening form of pneumonia in humans. Coronavirus replication and transcription are highly specialized processes of cytoplasmic RNA synthesis that localize to virus-induced membrane structures and were recently proposed to involve a complex enzymatic machinery that, besides RNA-dependent RNA polymerase, helicase, and protease activities, also involves a series of RNA-processing enzymes that are not found in most other

APA, Harvard, Vancouver, ISO, and other styles

3

A El-Masry, Eman. "Immunization against severe acute respiratory syndrome Coronavirus 2: an overview." African Health Sciences 21, no. 4 (2021): 1574–83. http://dx.doi.org/10.4314/ahs.v21i4.11.

Full text

Abstract:

In the past years, numerous new fatal infections have emerged, including Ebola, Nipah, and Zika viruses, as well as coronaviruses. Recently, infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged in China, and were then transmitted all over the world, causing the coronavirus disease-19 (COVID-19) pandemic, which is transmitted at a higher rate than other diseases caused by coronaviruses. At the time of writing this review, COVID-19 is not contained in most countries in spite of quarantine, physical distancing, and enhanced hygiene measures. In this review, I

APA, Harvard, Vancouver, ISO, and other styles

4

Zoghi, Sina, Hossein Jafari Khamirani, Seyed Alireza Dastgheib, Mehdi Dianatpour, and Alireza Ghaffarieh. "An analysis of inhibition of the severe acute respiratory syndrome coronavirus 2 RNA-dependent RNA polymerase by zinc ion: an in silico approach." Future Virology 16, no. 5 (2021): 331–39. http://dx.doi.org/10.2217/fvl-2020-0369.

Full text

Abstract:

Background: Coronavirus disease 2019 is caused by exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was reported that Zn2+ is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV). We hypothesize that the same applies to the newly discovered SARS-CoV-2. Material & methods: We compared the structure of RNA-dependent RNA polymerase between SARS-CoV and SARS-CoV-2. The RdRp’s binding to Zn2+ was studied by metal ion-binding site prediction and docking server. Results: Several regions containing key residues were detected. The functional aspartic a

APA, Harvard, Vancouver, ISO, and other styles

5

Lamirande, Elaine W., Marta L. DeDiego, Anjeanette Roberts, et al. "A Live Attenuated Severe Acute Respiratory Syndrome Coronavirus Is Immunogenic and Efficacious in Golden Syrian Hamsters." Journal of Virology 82, no. 15 (2008): 7721–24. http://dx.doi.org/10.1128/jvi.00304-08.

Full text

Abstract:

ABSTRACT The immunogenicity and protective efficacy of a live attenuated vaccine consisting of a recombinant severe acute respiratory syndrome (SARS) coronavirus lacking the E gene (rSARS-CoV-ΔE) were studied using hamsters. Hamsters immunized with rSARS-CoV-ΔE developed high serum-neutralizing antibody titers and were protected from replication of homologous (SARS-CoV Urbani) and heterologous (GD03) SARS-CoV in the upper and lower respiratory tract. rSARS-CoV-ΔE-immunized hamsters remained active following wild-type virus challenge, while mock-immunized hamsters displayed decreased activity.

APA, Harvard, Vancouver, ISO, and other styles

6

Fylenko, B. M., V. I. Babenko, N. V. Royko, I. I. Starchenko, S. A. Proskurnya, and A. O. Byelyayeva. "Morphological Manifestations of COVID-19-Associated Pneumonia." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 7, no. 2 (2022): 82–87. http://dx.doi.org/10.26693/jmbs07.02.082.

Full text

Abstract:

The purpose of study was to study the pathomorphological changes of COVID-19-associated pneumonia in its severe course on the basis of autopsies with substantiation of pathogenetic links of clinical and morphological manifestations. Materials and methods. The study of changes of COVID-19-associated pneumonia in its severe course was performed on the basis of autopsies of 16 deceased individuals using macroscopic and microscopic methods. All patients had chronic diseases during their lifetime, which contributed to the severe course of COVID-19. Results and discussion. The severe course of COVID

APA, Harvard, Vancouver, ISO, and other styles

7

Isnaini, Nadia, Khairan Khairan, Meutia Faradhilla, et al. "A Study of Essential Oils from Patchouli (Pogostemon cablin Benth.) and Its Potential as an Antivirus Agent to Relieve Symptoms of COVID-19." Journal of Patchouli and Essential Oil Products 1, no. 2 (2022): 27–35. http://dx.doi.org/10.24815/jpeop.v1i2.23763.

Full text

Abstract:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new type of virus that attacks the respiratory system and has caused the global epidemic of coronavirus disease 2019 (COVID-19). Some persons who are infected with this virus develop symptoms ranging from a typical cold to fever to more severe illnesses, such as Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). The development of a SARS-CoV-2 vaccine is being actively researched but will likely take more than a year to become available to the general public. As a result, numerous researchers a

APA, Harvard, Vancouver, ISO, and other styles

8

Mostafa, Ahmed, Ahmed Kandeil, Yaseen A. M. M. Elshaier, et al. "FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2." Pharmaceuticals 13, no. 12 (2020): 443. http://dx.doi.org/10.3390/ph13120443.

Full text

Abstract:

(1) Background: Drug repositioning is an unconventional drug discovery approach to explore new therapeutic benefits of existing drugs. Currently, it emerges as a rapid avenue to alleviate the COVID-19 pandemic disease. (2) Methods: Herein, we tested the antiviral activity of anti-microbial and anti-inflammatory Food and Drug Administration (FDA)-approved drugs, commonly prescribed to relieve respiratory symptoms, against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the viral causative agent of the COVID-19 pandemic. (3) Results: Of these FDA-approved antimicrobial drugs, Azith

APA, Harvard, Vancouver, ISO, and other styles

9

Poutanen, Susan M., Mary Vearncombe, Allison J. McGeer, Michael Gardam, Grant Large, and Andrew E. Simor. "Nosocomial Acquisition of Methicillin-ResistantStaphylococcus aureusDuring an Outbreak of Severe Acute Respiratory Syndrome." Infection Control & Hospital Epidemiology 26, no. 2 (2005): 134–37. http://dx.doi.org/10.1086/502516.

Full text

Abstract:

AbstractObjective:The four hospitals assessed in this study use active surveillance cultures for methicillin-resistantStaphylococcus aureus(MRSA) and contact precautions for MRSA-positive patients as part of routine infection control practices. The objective of this study was to determine whether nosocomial acquisition of MRSA decreased in these hospitals during an outbreak of severe acute respiratory syndrome (SARS) when barrier precautions were routinely used for all patients.Design:Retrospective cohort study.Setting:Three tertiary-care hospitals (a 1,100-bed hospital; a 500-bed hospital; an

APA, Harvard, Vancouver, ISO, and other styles

10

Rha, Brian, Joana Y. Lively, Janet A. Englund, et al. "Severe Acute Respiratory Syndrome Coronavirus 2 Infections in Children: Multicenter Surveillance, United States, January–March 2020." Journal of the Pediatric Infectious Diseases Society 9, no. 5 (2020): 609–12. http://dx.doi.org/10.1093/jpids/piaa075.

Full text

Abstract:

Abstract Previous reports of coronavirus disease 2019 among children in the United States have been based on health jurisdiction reporting. We performed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing on children enrolled in active, prospective, multicenter surveillance during January–March 2020. Among 3187 children, only 4 (0.1%) SARS-CoV-2–positive cases were identified March 20–31 despite evidence of rising community circulation.

APA, Harvard, Vancouver, ISO, and other styles

11

Hashimi, Marziah, Thomas Sebrell, Jodi Hedges, et al. "Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Infection in a Bat Gastrointestinal Organoid Model." Journal of Immunology 208, no. 1_Supplement (2022): 125.34. http://dx.doi.org/10.4049/jimmunol.208.supp.125.34.

Full text

Abstract:

Abstract The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19, is thought to have originated in bats, since multiple viruses with a high level of genetic similarity have been identified in bats. In addition to respiratory symptoms, COVID-19 frequently involves gastrointestinal symptoms such as diarrhea and vomiting, indicating the SARS-CoV-2 can target the gastrointestinal (GI) tract. However, there is no robust in vitro model for assessing the SARS-CoV-2 infection in the bat GI tract. Here, we established gastrointestinal organoid cultures from Jam

APA, Harvard, Vancouver, ISO, and other styles

12

Borbone, Nicola, Gennaro Piccialli, Giovanni Nicola Roviello, and Giorgia Oliviero. "Nucleoside Analogs and Nucleoside Precursors as Drugs in the Fight against SARS-CoV-2 and Other Coronaviruses." Molecules 26, no. 4 (2021): 986. http://dx.doi.org/10.3390/molecules26040986.

Full text

Abstract:

Coronaviruses (CoVs) are positive-sense RNA enveloped viruses, members of the family Coronaviridae, that cause infections in a broad range of mammals including humans. Several CoV species lead to mild upper respiratory infections typically associated with common colds. However, three human CoV (HCoV) species: Severe Acute Respiratory Syndrome (SARS)-CoV-1, Middle East Respiratory Syndrome (MERS)-CoV, and SARS-CoV-2, are responsible for severe respiratory diseases at the origin of two recent epidemics (SARS and MERS), and of the current COronaVIrus Disease 19 (COVID-19), respectively. The easil

APA, Harvard, Vancouver, ISO, and other styles

13

McGill, Andrew R., Roukiah Kahlil, Rinku Dutta, et al. "SARS–CoV-2 Immuno-Pathogenesis and Potential for Diverse Vaccines and Therapies: Opportunities and Challenges." Infectious Disease Reports 13, no. 1 (2021): 102–25. http://dx.doi.org/10.3390/idr13010013.

Full text

Abstract:

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a novel coronavirus that emerged from Wuhan, China in late 2019 causing coronavirus disease-19 (COVID-19). SARS-CoV-2 infection begins by attaching to angiotensin-converting enzyme 2 receptor (ACE2) via the spike glycoprotein, followed by cleavage by TMPRSS2, revealing the viral fusion domain. Other presumptive receptors for SARS-CoV-2 attachment include CD147, neuropilin-1 (NRP1), and Myeloid C-lectin like receptor (CLR), each of which might play a role in the systemic viral spread. The pathology of SARS-CoV-2 infection ranges fr

APA, Harvard, Vancouver, ISO, and other styles

14

Kwaan, Hau C., and Paul F. Lindholm. "The Central Role of Fibrinolytic Response in COVID-19—A Hematologist’s Perspective." International Journal of Molecular Sciences 22, no. 3 (2021): 1283. http://dx.doi.org/10.3390/ijms22031283.

Full text

Abstract:

The novel coronavirus disease (COVID-19) has many characteristics common to those in two other coronavirus acute respiratory diseases, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). They are all highly contagious and have severe pulmonary complications. Clinically, patients with COVID-19 run a rapidly progressive course of an acute respiratory tract infection with fever, sore throat, cough, headache and fatigue, complicated by severe pneumonia often leading to acute respiratory distress syndrome (ARDS). The infection also involves other organs throughout

APA, Harvard, Vancouver, ISO, and other styles

15

Parihar, Arpana, Tabassum Zafar, Rekha Khandia, et al. "In silico Analysis for the Repurposing of Broad-spectrum Antiviral Drugs against Multiple Targets from SARS-CoV-2: A Molecular Docking and ADMET Approach." Archives of Proteomics and Bioinformatics 3, no. 1 (2023): 3–14. http://dx.doi.org/10.33696/proteomics.3.012.

Full text

Abstract:

Background: Amidst the second wave of COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led the world devastated, and resulted in the death of millions of people with its deadly virulence potential. In comparison to similar virus outbreaks, such as severe acute respiratory syndrome coronavirus(SARS CoV) and middle east respiratory syndrome coronavirus (MERS CoV), COVID-19 led to severe morbidity and mortality. Various therapeutic interventions to combat the SARS-CoV-2 infection are actively investigated, but still, there is no specific drug with high anti

APA, Harvard, Vancouver, ISO, and other styles

16

Yao, Lin, Peijun Tang, Hui Jiang, et al. "Household Clusters of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Suzhou, China." BioMed Research International 2021 (October 16, 2021): 1–7. http://dx.doi.org/10.1155/2021/5565549.

Full text

Abstract:

Objectives. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging virus causing substantial morbidity and mortality worldwide. We performed a cross-sectional investigation of SARS-CoV-2 clusters in Suzhou to determine the transmissibility of the virus among close contacts and to assess the demographic and clinical characteristics between index and secondary cases. Methods. We review the clustered patients with SARS-CoV-2 infections in Suzhou between 22 January and 29 February 2020. The demographic and clinical characteristics were compared between index and secondary

APA, Harvard, Vancouver, ISO, and other styles

17

Choy, Wai-Yan, Shu-Guang Lin, Paul Kay-Sheung Chan, et al. "Synthetic Peptide Studies on the Severe Acute Respiratory Syndrome (SARS) Coronavirus Spike Glycoprotein: Perspective for SARS Vaccine Development." Clinical Chemistry 50, no. 6 (2004): 1036–42. http://dx.doi.org/10.1373/clinchem.2003.029801.

Full text

Abstract:

Abstract Background: The S (spike) protein of the etiologic coronavirus (CoV) agent of severe acute respiratory syndrome (SARS) plays a central role in mediating viral infection via receptor binding and membrane fusion between the virion and the host cell. We focused on using synthetic peptides for developing antibodies against SARS-CoV, which aimed to block viral invasion by eliciting an immune response specific to the native SARS-CoV S protein. Methods: Six peptide sequences corresponding to the surface regions of SARS-CoV S protein were designed and investigated by use of combined bioinform

APA, Harvard, Vancouver, ISO, and other styles

18

Schulze, Jessica, Christin Mache, Anita Balázs, et al. "Analysis of Severe Acute Respiratory Syndrome 2 Replication in Explant Cultures of the Human Upper Respiratory Tract Reveals Broad Tissue Tropism of Wild-Type and B.1.1.7 Variant Viruses." Journal of Infectious Diseases 224, no. 12 (2021): 2020–24. http://dx.doi.org/10.1093/infdis/jiab523.

Full text

Abstract:

Abstract Background The upper respiratory tract (URT) is the primary entry site for severe acute respiratory syndrome 2 (SARS-CoV-2) and other respiratory viruses, but its involvement in viral amplification and pathogenesis remains incompletely understood. Methods In this study, we investigated primary nasal epithelial cultures, as well as vital explanted tissues, to scrutinize the tropism of wild-type SARS-CoV-2 and the recently emerged B.1.1.7 variant. Results Our analyses revealed a widespread replication competence of SARS-CoV-2 in polarized nasal epithelium as well as in the examined URT

APA, Harvard, Vancouver, ISO, and other styles

19

Lungu, Claudiu N., Melinda E. Füstös, Ireneusz P. Grudziński, Gabriel Olteanu, and Mihai V. Putz. "Protein Interaction with Dendrimer Monolayers: Energy and Surface Topology." Symmetry 12, no. 4 (2020): 641. http://dx.doi.org/10.3390/sym12040641.

Full text

Abstract:

Protein interaction with polymers layers is a keystone in designing bio-nano devices. Polyamidoamines (PAMAMs) are well-known polymers. Zero aromatic core dendrimers (ZAC) are molecules with no proven toxic effect in cultured cells. When coating nanodevices with enzymatic systems, active sites are disturbed by an interaction with the biosystem surface. Computational methods were used in order to simulate, characterize, and quantify protein–polymer interaction. Protein corona, i.e., surface proteins disposed on a viral membrane or nanodevice outer surface, are crucial in interactions with a pot

APA, Harvard, Vancouver, ISO, and other styles

20

Ingallinella, P., E. Bianchi, M. Finotto, et al. "Structural characterization of the fusion-active complex of severe acute respiratory syndrome (SARS) coronavirus." Proceedings of the National Academy of Sciences 101, no. 23 (2004): 8709–14. http://dx.doi.org/10.1073/pnas.0402753101.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Neuman, Benjamin W., David A. Stein, Andrew D. Kroeker, et al. "Inhibition, Escape, and Attenuated Growth of Severe Acute Respiratory Syndrome Coronavirus Treated with Antisense Morpholino Oligomers." Journal of Virology 79, no. 15 (2005): 9665–76. http://dx.doi.org/10.1128/jvi.79.15.9665-9676.2005.

Full text

Abstract:

ABSTRACT The recently emerged severe acute respiratory syndrome coronavirus (SARS-CoV) is a potent pathogen of humans and is capable of rapid global spread. Peptide-conjugated antisense morpholino oligomers (P-PMO) were designed to bind by base pairing to specific sequences in the SARS-CoV (Tor2 strain) genome. The P-PMO were tested for their capacity to inhibit production of infectious virus as well as to probe the function of conserved viral RNA motifs and secondary structures. Several virus-targeted P-PMO and a random-sequence control P-PMO showed low inhibitory activity against SARS corona

APA, Harvard, Vancouver, ISO, and other styles

22

Priyandoko, Didik, Wahyu Widowati, Mawar Subangkit, et al. "Molecular Docking Study of the Potential Relevance of the Natural Compounds Isoflavone and Myricetin to COVID-19." International Journal Bioautomation 25, no. 3 (2021): 271–82. http://dx.doi.org/10.7546/ijba.2021.25.3.000796.

Full text

Abstract:

The 2019 novel coronavirus (2019-nCoV) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly from its origin in Wuhan City, Hubei Province, China, to the rest of the world. The efficacy of herbal treatment in the control of contagious disease was demonstrated during the 2003 outbreak of severe acute respiratory syndrome (SARS). Natural compound used for this study were isoflavone and myricetin. Molecular docking was performed to analyze binding mode of the compounds towards 12 proteins related to COVID-19. The prediction shows that isoflavone and myricetin have mod

APA, Harvard, Vancouver, ISO, and other styles

23

Donadel, Marcelo Menegotto, Lucas Montiel Petry, Carolina Boeira Soares, Laura de Castro e. Garcia, Luana Braga Bittencourt, and Luiz Carlos Bodanese. "Analysis of the impact of pronation maneuver in patients on mechanical ventilation with diagnosis of pneumonia by Covid-19 and acute respiratory distress syndrome." Brazilian Journal of Health Review 5, no. 6 (2022): 24053–64. http://dx.doi.org/10.34119/bjhrv5n6-175.

Full text

Abstract:

Objective: To analyze the profile of patients on invasive mechanical ventilation with SARS-CoV-2 pneumonia who were pronated and who developed acute respiratory distress syndrome. Methods: Historical cohort study through the analysis of a database containing 282 patients hospitalized in a large university hospital in the city of Porto Alegre, Brazil. The population studied included individuals infected with SARS-CoV-2 and with a clinical course marked by severe pneumonia and, mainly, by acute respiratory distress syndrome, submitted to mechanical ventilation and invasive pronation maneuver. Re

APA, Harvard, Vancouver, ISO, and other styles

24

Rajasekharan, Sreejith, Rafaela Milan Bonotto, Lais Nascimento Alves, et al. "Inhibitors of Protein Glycosylation Are Active against the Coronavirus Severe Acute Respiratory Syndrome Coronavirus SARS-CoV-2." Viruses 13, no. 5 (2021): 808. http://dx.doi.org/10.3390/v13050808.

Full text

Abstract:

Repurposing clinically available drugs to treat the new coronavirus disease 2019 (COVID-19) is an urgent need in the course of the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2) pandemic, as very few treatment options are available. The iminosugar Miglustat is a well-characterized drug for the treatment of rare genetic lysosome storage diseases, such as Gaucher and Niemann-Pick type C, and has also been described to be active against a variety of enveloped viruses. The activity of Miglustat is here demonstrated in the micromolar range for SARS-CoV-2 in vitro. The drug acts at the p

APA, Harvard, Vancouver, ISO, and other styles

25

Nakayoshi, Tomoki, Koichi Kato, Eiji Kurimoto, and Akifumi Oda. "Virtual Alanine Scan of the Main Protease Active Site in Severe Acute Respiratory Syndrome Coronavirus 2." International Journal of Molecular Sciences 22, no. 18 (2021): 9837. http://dx.doi.org/10.3390/ijms22189837.

Full text

Abstract:

Recently, inhibitors of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) have been proposed as potential therapeutic agents for COVID-19. Studying effects of amino acid mutations in the conformation of drug targets is necessary for anticipating drug resistance. In this study, with the structure of the SARS-CoV-2 Mpro complexed with a non-covalent inhibitor, we performed molecular dynamics (MD) simulations to determine the conformation of the complex when single amino acid residue in the active site is mutated. As a model of amino acid mutation, we construct

APA, Harvard, Vancouver, ISO, and other styles

26

Denisov, M. S., and Ya A. Beloglazova. "Anticoronaviral activity of triterpenoids." Biomedical Chemistry: Research and Methods 3, no. 2 (2020): e00127. http://dx.doi.org/10.18097/bmcrm00127.

Full text

Abstract:

The discovery and investigations of new therapeutic agents with anticoronaviral activity is extremely important due to the COVID-19 pandemic caused by the SARS-CoV-2 virus. Currently, there are no anti-COVID-19 drugs, characterized by efficacy which has been proved in correspondence with criteria of evidence-based medicine. However, there are some anti SARS-CoV-2 drugs, acting on the other Coronaviridae family member causing SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome). Consequently, a wide range of organic substances of synthetic and natural origin were

APA, Harvard, Vancouver, ISO, and other styles

27

Shobiroh Nuur'Alimah, Agnia Nurul Jannati, Laksmi Ambarsari, and Syamsul Falah. "In silico study: molecular docking of SARS-Cov-2 endoribonuclease on active compounds of Gmelina arborea Roxb. bark." E-Journal Menara Perkebunan 92, no. 1 (2024): 70–81. http://dx.doi.org/10.22302/iribb.jur.mp.v92i1.561.

Full text

Abstract:

Infection by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) triggers COVID-19 disease of the respiratory tract similar to pneumonia. The virus encodes four structural proteins and 16 non-structural proteins (nsp), one of which includes nsp15 or endoribonuclease (NendoU). NendoU plays an important role in viral replication and transcription and reduces the stimulation of immune cell responses. Active compounds in Gmelina arborea Roxb. bark have antioxidant properties that can inhibit the NendoU activity of SARS-CoV-2. This study aims to analyze the potential of compounds from Gmel

APA, Harvard, Vancouver, ISO, and other styles

28

Sada, Mitsuru, Takeshi Saraya, Haruyuki Ishii, et al. "Detailed Molecular Interactions of Favipiravir with SARS-CoV-2, SARS-CoV, MERS-CoV, and Influenza Virus Polymerases In Silico." Microorganisms 8, no. 10 (2020): 1610. http://dx.doi.org/10.3390/microorganisms8101610.

Full text

Abstract:

Favipiravir was initially developed as an antiviral drug against influenza and is currently used in clinical trials against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection (COVID-19). This agent is presumably involved in RNA chain termination during influenza virus replication, although the molecular interactions underlying its potential impact on the coronaviruses including SARS-CoV-2, SARS-CoV, and Middle East respiratory syndrome coronavirus (MERS-CoV) remain unclear. We performed in silico studies to elucidate detailed molecular interactions between favipiravir and t

APA, Harvard, Vancouver, ISO, and other styles

29

Bedford, Trevor, Alexander L. Greninger, Pavitra Roychoudhury, et al. "Cryptic transmission of SARS-CoV-2 in Washington state." Science 370, no. 6516 (2020): 571–75. http://dx.doi.org/10.1126/science.abc0523.

Full text

Abstract:

After its emergence in Wuhan, China, in late November or early December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus rapidly spread globally. Genome sequencing of SARS-CoV-2 allows the reconstruction of its transmission history, although this is contingent on sampling. We analyzed 453 SARS-CoV-2 genomes collected between 20 February and 15 March 2020 from infected patients in Washington state in the United States. We find that most SARS-CoV-2 infections sampled during this time derive from a single introduction in late January or early February 2020, which subse

APA, Harvard, Vancouver, ISO, and other styles

30

Citarella, Andrea, Alessandro Dimasi, Davide Moi, et al. "Recent Advances in SARS-CoV-2 Main Protease Inhibitors: From Nirmatrelvir to Future Perspectives." Biomolecules 13, no. 9 (2023): 1339. http://dx.doi.org/10.3390/biom13091339.

Full text

Abstract:

The main protease (Mpro) plays a pivotal role in the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target. Disruption of the catalytic activity of Mpro produces a detrimental effect on the course of the infection, making this target one of the most attractive for the treatment of COVID-19. The current success of the SARS-CoV-2 Mpro inhibitor Nirmatrelvir, the first oral drug for the treatment of severe forms of COVID-19, has further focused the attention of researchers on this important viral target, making the search for

APA, Harvard, Vancouver, ISO, and other styles

31

Schwerdtner, Marie, Luna C. Schmacke, Julia Nave, et al. "Unveiling the Role of TMPRSS2 in the Proteolytic Activation of Pandemic and Zoonotic Influenza Viruses and Coronaviruses in Human Airway Cells." Viruses 16, no. 11 (2024): 1798. http://dx.doi.org/10.3390/v16111798.

Full text

Abstract:

The zoonotic transmission of influenza A viruses (IAVs) and coronaviruses (CoVs) may result in severe disease. Cleavage of the surface glycoproteins hemagglutinin (HA) and spike protein (S), respectively, is essential for viral infectivity. The transmembrane serine protease 2 (TMPRSS2) is crucial for cleaving IAV HAs containing monobasic cleavage sites and severe acute respiratory syndrome (SARS)-CoV-2 S in human airway cells. Here, we analysed and compared the TMPRSS2-dependency of SARS-CoV, Middle East respiratory syndrome (MERS)-CoV, the 1918 pandemic H1N1 IAV and IAV H12, H13 and H17 subty

APA, Harvard, Vancouver, ISO, and other styles

32

Jugler, Collin, Haiyan Sun, and Qiang Chen. "SARS-CoV-2 Spike Protein-Induced Interleukin 6 Signaling Is Blocked by a Plant-Produced Anti-Interleukin 6 Receptor Monoclonal Antibody." Vaccines 9, no. 11 (2021): 1365. http://dx.doi.org/10.3390/vaccines9111365.

Full text

Abstract:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the current COVID-19 pandemic, has caused more than 4.5 million deaths worldwide. Severe and fatal cases of COVID-19 are often associated with increased proinflammatory cytokine levels including interleukin 6 (IL-6) and acute respiratory distress syndrome. In this study, we explored the feasibility of using plants to produce an anti-IL-6 receptor (IL-6R) monoclonal antibody (mAb) and examined its utility in reducing IL-6 signaling in an in vitro model, which simulates IL-6 induction during SARS-CoV-2 infection

APA, Harvard, Vancouver, ISO, and other styles

33

Snow-Smith, Maryonne, Paul J. Baker, Andrea C. Bohrer, et al. "Investigating a Role for Eosinophils in the Immune Response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)." Journal of Immunology 210, no. 1_Supplement (2023): 73.10. http://dx.doi.org/10.4049/jimmunol.210.supp.73.10.

Full text

Abstract:

Abstract Eosinophils rapidly decrease in the peripheral blood of patients during COVID-19, and eosinopenia has been correlated with disease severity. These clinical observations suggest that eosinophils may play a functional role in the response to SARS-CoV-2 infection. Murine studies have shown that eosinophils can be recruited to the lungs in response to infection with respiratory viruses, including RSV and influenza and parainfluenza viruses, yet the role of eosinophils in the lungs in response to SARS-CoV-2 infection is unknown. Here, we used a two-pronged approach employing mouse models o

APA, Harvard, Vancouver, ISO, and other styles

34

Salman, Saad, Fahad Hassan Shah, Maham Chaudhry, Muniba Tariq, Muhammad Yasir Akbar, and Muhammad Adnan. "In silico analysis of protein/peptide-based inhalers against SARS-CoV-2." Future Virology 15, no. 9 (2020): 557–64. http://dx.doi.org/10.2217/fvl-2020-0119.

Full text

Abstract:

Aim: Peptide/protein-based inhalers are excessively used to treat respiratory disorders. The molecular docking was performed for these inhalers including human neutralizing S230 light chain-antibody (monoclonal antibodies [mAbs]), alpha-1-antitrypsin (AAT), short-palate-lung and nasal-epithelial clone-1-derived peptides (SPLUNC1) and dornase-alfa (DA) against spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to assess their inhibitory activity. Materials & methods: HawkDock was used to dock these biologics against SARS-CoV-2 spike-glycoprotein. Results: Res

APA, Harvard, Vancouver, ISO, and other styles

35

Shigeta, Shiro, and Toshihiro Yamase. "Current Status of Anti-SARS Agents." Antiviral Chemistry and Chemotherapy 16, no. 1 (2005): 23–31. http://dx.doi.org/10.1177/095632020501600103.

Full text

Abstract:

Severe acute respiratory syndrome (SARS) is a disease that has newly emerged in the 21st century, and is both severe and highly contagious. SARS first surfaced in late 2002 and spread within a few months from its origin in Guandong province, China, to more than 30 countries (World Health Organization, 2003). In this review, several antiviral substances shown to be active in vitro will be introduced and summarized in the order of the virus' replication steps; that is, binding to cellular receptor, fusion and entry to the cells, viral RNA replication and transcription, protein processing and so

APA, Harvard, Vancouver, ISO, and other styles

36

Salman, Saad, Fahad H. Shah, Jawaria Idrees, et al. "Virtual screening of immunomodulatory medicinal compounds as promising anti-SARS-CoV-2 inhibitors." Future Virology 15, no. 5 (2020): 267–75. http://dx.doi.org/10.2217/fvl-2020-0079.

Full text

Abstract:

Aim: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a pernicious viral disease, causes acute respiratory distress responsible for mortality and morbidity worldwide. To screen different immunomodulatory medicinal compounds to unravel their interaction with SARS-CoV-2 viral proteins. Materials & methods: A library of immunomodulatory medicinal compounds with antiviral capability were analyzed against SARS proteases, spike protein and nonstructural proteins (NSP-9, 15) using Autodock vina. Results: Out of more than 300 medicinal compounds, only six compounds: arzanol, ferulic a

APA, Harvard, Vancouver, ISO, and other styles

37

Ożarowski, Marcin, and Tomasz M. Karpiński. "The Effects of Propolis on Viral Respiratory Diseases." Molecules 28, no. 1 (2023): 359. http://dx.doi.org/10.3390/molecules28010359.

Full text

Abstract:

Propolis remains an interesting source of natural chemical compounds that show, among others, antibacterial, antifungal, antiviral, antioxidative and anti-inflammatory activities. Due to the growing incidence of respiratory tract infections caused by various pathogenic viruses, complementary methods of prevention and therapy supporting pharmacotherapy are constantly being sought out. The properties of propolis may be important in the prevention and treatment of respiratory tract diseases caused by viruses such as severe acute respiratory syndrome coronavirus 2, influenza viruses, the parainflu

APA, Harvard, Vancouver, ISO, and other styles

38

Kullappan, Malathi, Jenifer M Ambrose, and Surapaneni Krishna Mohan. "Lead Identification for Severe Acute Respiratory Syndrome Coronavirus-2 Spike D614G Variant of COVID-19: A virtual Screening Process." Biomedical and Pharmacology Journal 14, no. 4 (2021): 1929–39. http://dx.doi.org/10.13005/bpj/2291.

Full text

Abstract:

COVID-19, a pandemic disease caused by single-stranded RNA virus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The structural spike (S) protein of SARS-CoV-2 plays a vital role in host cell entry, where the Angiotensin-Converting Enzyme-2 (ACE2) receptor of the human cell binds to the Receptor Binding Domain (RBD) region of the S1 domain and makes cell entry. The binding affinity of SARS-CoV-2-ACE2 is tenfold higher than the SARS-CoV-1-ACE2. Recent studies expose that the SARS-CoV-2 S D614G variant is highly infectious than D614 protein, also the D614G variant is highly stable

APA, Harvard, Vancouver, ISO, and other styles

39

Pignolo, Antonia, Maria Aprile, Cesare Gagliardo, et al. "Clinical Onset and Multiple Sclerosis Relapse after SARS-CoV-2 Infection." Neurology International 13, no. 4 (2021): 695–700. http://dx.doi.org/10.3390/neurolint13040066.

Full text

Abstract:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been associated with several neurological disorders including headache, facial palsy, encephalitis, stroke, demyelinating disorders. The present report will discuss cases of multiple sclerosis (MS) onset and relapse both beginning early after SARS-CoV-2 infection. In both cases, magnetic resonance imaging (MRI) showed widespread bilateral subcortical and periventricular active lesions. Serum IgG against SARS-CoV-2 Spike antigens confirmed seroconversion with titers that are considered not definitely protective against p

APA, Harvard, Vancouver, ISO, and other styles

40

Daneshmandi, Zahra, Guitti Pourdowlat, Mahsa Rekabi, et al. "Coronavirus Disease 2019 and Mycobacterium tuberculosis Reactivation and Coinfections." Journal of Preventive, Diagnostic and Treatment Strategies in Medicine 1, no. 2 (2022): 76–81. http://dx.doi.org/10.4103/jpdtsm.jpdtsm_6_22.

Full text

Abstract:

The emergence of coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), greatly affects the health systems and socioeconomic parameters. Post pandemic, the SARS-CoV-2 might activate dormant bacterial infections like Mycobacterium tuberculosis in the long term. The mechanism of tuberculosis (TB) reactivation is still not clear, but it is thought that in healthy individuals, a strong immune response can form granulomatous lesion and prevents the development of active TB, while, in patients with dysregulated immune systems, TB reactivation occurs. Here,

APA, Harvard, Vancouver, ISO, and other styles

41

Zhong, Nan, Shengnan Zhang, Peng Zou, et al. "Without Its N-Finger, the Main Protease of Severe Acute Respiratory Syndrome Coronavirus Can Form a Novel Dimer through Its C-Terminal Domain." Journal of Virology 82, no. 9 (2008): 4227–34. http://dx.doi.org/10.1128/jvi.02612-07.

Full text

Abstract:

ABSTRACT The main protease (Mpro) of severe acute respiratory syndrome coronavirus (SARS-CoV) plays an essential role in the extensive proteolytic processing of the viral polyproteins (pp1a and pp1ab), and it is an important target for anti-SARS drug development. It was found that SARS-CoV Mpro exists in solution as an equilibrium of both monomeric and dimeric forms, and the dimeric form is the enzymatically active form. However, the mechanism of SARS-CoV Mpro dimerization, especially the roles of its N-terminal seven residues (N-finger) and its unique C-terminal domain in the dimerization, re

APA, Harvard, Vancouver, ISO, and other styles

42

Pratapa, Sree Karthik, Sourya Acharya, Sai Spoorthy Mamidipalli, and Amol Andhale. "Caring for Cancer Patients during Corona Pandemic—(COVID-19)—A Narrative Review." South Asian Journal of Cancer 10, no. 01 (2021): 19–22. http://dx.doi.org/10.1055/s-0040-1721292.

Full text

Abstract:

Abstract Background Coronavirus disease 2019, the third pandemic of 21st century which has brought the whole world under panic, is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a zoonotic beta coronavirus sharing phylogenetic, genomic similarities with SARS virus and Middle East Respiratory Syndrome virus. Specific Concerns Cancer patients are at double the risk than normal patients since these patients are at immunocompromised state. WHO guidelines advice the patients to plan only emergency hospital visits only till the pandemic persists. Should meet patient/visitors

APA, Harvard, Vancouver, ISO, and other styles

43

Gordon, Calvin J., Egor P. Tchesnokov, Emma Woolner, et al. "Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency." Journal of Biological Chemistry 295, no. 20 (2020): 6785–97. http://dx.doi.org/10.1074/jbc.ra120.013679.

Full text

Abstract:

Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Replication of SARS-CoV-2 depends on the viral RNA-dependent RNA polymerase (RdRp), which is the likely target of the investigational nucleotide analogue remdesivir (RDV). RDV shows broad-spectrum antiviral activity against RNA viruses, and previous studies with RdRps from Ebola virus and Middle East respiratory syndrome coronavirus (MERS-CoV) have revealed that delayed chain termination is RDV's plausible mec

APA, Harvard, Vancouver, ISO, and other styles

44

Wang, Wenxiang, Ce Yang, Jing Xia, Ning Li, and Wei Xiong. "Luteolin is a potential inhibitor of COVID-19: An in silico analysis." Medicine 102, no. 38 (2023): e35029. http://dx.doi.org/10.1097/md.0000000000035029.

Full text

Abstract:

The severe respiratory syndrome 2019 novel coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread explosively, raising global health concerns. Luteolin shows antiviral properties, but its effect on SARS-CoV-2 and the associated mechanisms are not elucidated. We used network pharmacology, molecular docking and molecular dynamics to provide potential molecular support of luteolin (3,4,5,7-tetrahydroxyflavone) (LUT) against COVID-19. We employed network pharmacology, molecular docking, and molecular dynamics techniques to investigate h

APA, Harvard, Vancouver, ISO, and other styles

45

Elaiw, Ahmed, Abdualla Alsaedi, Aatef Hobiny, and Shaban Aly. "Global Properties of a Diffusive SARS-CoV-2 Infection Model with Antibody and Cytotoxic T-Lymphocyte Immune Responses." Mathematics 11, no. 1 (2022): 190. http://dx.doi.org/10.3390/math11010190.

Full text

Abstract:

A severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to morbidity and mortality. SARS-CoV-2 infects the epithelial cells of the respiratory tract and causes coronavirus disease 2019 (COVID-19). The immune system’s response plays a significant role in viral progression. This article develops and analyzes a system of partial differential equations (PDEs), which describe the in-host dynamics of SARS-CoV-2 under the effect of cytotoxic T-lymphocyte (CTL) and antibody immune responses. The model characterizes the interplay between six compartments, healthy epithelial ce

APA, Harvard, Vancouver, ISO, and other styles

46

Dhakad, Prashant Kumar, Raghav Mishra, and Isha Mishra. "A Concise Review: Nutritional Interventions for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)." Natural Resources for Human Health 3, no. 4 (2023): 403–25. http://dx.doi.org/10.53365/nrfhh/175070.

Full text

Abstract:

Wuhan, China reported a novel coronavirus-related sickness in late 2019, which quickly spread into a global epidemic. One crucial factor in combating the coronavirus infection appears to be the presence of a robust, long-lasting, and active immune system. The immune response is affected by several factors, including food. Nutritional insufficiency can cause immune deficits, making infections more likely to cause fatality. Thus, understanding numerous behaviors, particularly dietary habits, is essential to determining their capacity to reduce severe acute respiratory syndrome coronavirus 2 risk

APA, Harvard, Vancouver, ISO, and other styles

47

Gorbunov, A. A., L. E. Sorokina, D. V. Chegodar, A. V. Kubyshkin, and I. I. Fomochkina. "COVID-19 DIAGNOSTICS: CURRENT STATE OF THE PROBLEM AND PROSPECTS IN THE BRANCH." Crimea Journal of Experimental and Clinical Medicine 10, no. 2 (2020): 69–77. http://dx.doi.org/10.37279/2224-6444-2020-10-2-69-77.

Full text

Abstract:

SARS-CoV-2 is a new representative of the world of virology related to coronaviruses and can cause a wide range of diseases of the respiratory system: from colds to acute respiratory distress-syndrome with severe respiratory failure. The pathogenesis of a new coronavirus infection (COVID-19) is associated with the ability of SARS-CoV-2 to bind to ACE receptors and subsequently activate IL-6, the main stimulator of the “cytokine storm”. Due to such features of the viral pathogenesis, early and accurate detection of active forms, as well as virus carriage are needed. In review, the whole spectru

APA, Harvard, Vancouver, ISO, and other styles

48

Saad-Roy, Chadi M., Caroline E. Wagner, Rachel E. Baker, et al. "Immune life history, vaccination, and the dynamics of SARS-CoV-2 over the next 5 years." Science 370, no. 6518 (2020): 811–18. http://dx.doi.org/10.1126/science.abd7343.

Full text

Abstract:

The future trajectory of the coronavirus disease 2019 (COVID-19) pandemic hinges on the dynamics of adaptive immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, salient features of the immune response elicited by natural infection or vaccination are still uncertain. We use simple epidemiological models to explore estimates for the magnitude and timing of future COVID-19 cases, given different assumptions regarding the protective efficacy and duration of the adaptive immune response to SARS-CoV-2, as well as its interaction with vaccines and nonpharmaceutical

APA, Harvard, Vancouver, ISO, and other styles

49

Singh, Akhilesh Vikram. "Potential of amentoflavone with antiviral properties in COVID-19 treatment." Asian Biomedicine 15, no. 4 (2021): 153–59. http://dx.doi.org/10.2478/abm-2021-0020.

Full text

Abstract:

Abstract Amentoflavone is one of the flavonoids that are known for their antiviral effects and many of them are predicted to have inhibitory effects against severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome Coronavirus (MERS-CoV) enzymes 3-chymotrypsin-like protease (3CLpro) and papain-like protease (PLpro). Amentoflavone is a biflavonoid found in the herbal extracts of St. John's wort (Hypericum perforatum), Gingko biloba, Selaginella tamariscina, Torreya nucifera, and many other plants. Its pharmacological actions have been listed as antiviral, ant

APA, Harvard, Vancouver, ISO, and other styles

50

Roy, Santanu, Prakash Chandra Ghosh, Mitali Bera, and Sananda Majumder. "Pulmonary involvement in multisystem inflammatory syndrome in children, a diagnostic conundrum: case series from a tertiary care hospital in eastern India." International Journal of Contemporary Pediatrics 9, no. 8 (2022): 762. http://dx.doi.org/10.18203/2349-3291.ijcp20221861.

Full text

Abstract:

In April 2020, a novel syndrome in children and adolescents, termed multisystem inflammatory syndrome in children (MIS-C), related to SARS-CoV-2 (severe acute respiratory syndrome corona virus 2) infection was first described in the United Kingdom and Italy. In this case series, we analysed 6 patients who had moderate to severe respiratory system manifestations at presentation, closely resembling the acute infection. A retrospective analysis of 6 pediatric patients, diagnosed as MIS-C, presenting with predominant respiratory system manifestations between December 2020 to October 2021 was under

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!