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Journal articles on the topic 'Sex determination, Diagnostic – Methods'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Hiort, Olaf. "Reasonable diagnostic pathways in disorders of sex development." Laboratoriumsmedizin 36, no. 2 (2012): 1–6. http://dx.doi.org/10.1515/jlm.2012.0004-et.

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AbstractDisorders of sex development or “DSD” describe a heterogeneous group of abnormalities of sexual determination and differentiation. This may be caused by chromosomal as well as monogenic aberrations, which may lead either primarily or through endocrine mechanisms to abnormal sexual development. Laboratory investigations play an important role in the diagnostic process. However, special analytical methods have to be taken into account and the usual reference intervals do not apply. Therefore, laboratory results should be interpreted in a specialized center in context with clinical and im

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Chertovskikh, A. A. "PROCEDURE FOR SEX DETERMINATION OF HUMAN SCAPULA." Russian Journal of Forensic Medicine 6, no. 1 (2020): 33–35. http://dx.doi.org/10.19048/2411-8729-2020-6-1-33-35.

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The determination of sex drawing on the differences in certain dimensions of skeletal bones constitutes one of the main tasks of forensic medicine and osteology.Aim. To develop informative and reliable science-based diagnostic criteria for sex determination (as part of personal identification in forensic medicine) on the basis of a number of parameters associated with the scapula, drawing on statistically calculated formulae.Material and methods. The study included 108 corpses of people, who died aged 19 to 99 years in the Central region of Russia in 2016 from cardiovascular diseases, acute po

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Holumbiovska, T. V., and V. Y. Stefanyk. "Disorders of reproductive function in female dogs and methods of diagnostic." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 20, no. 83 (2018): 385–95. http://dx.doi.org/10.15421/nvlvet8376.

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In recent years, small animals veterinary medicine in Ukraine has undergone significant development and change. The increase of issue of breeding, obtain healthy offspring leads to magnificatition disorders of reproduction function in dogs. Therefore, the development of modern methods for diagnosis of reproductive system diseases and correction of reproductive function in dogs is important. Infertility is a temporary or prolonged loss of reproductive capacity by the female dogs as a result of various factors inborn or acquired in the process of life. Disorders of reproduction function caused b

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Kalimullin, Rafkat R., and Viktor N. Zvyagin. "Methods for diagnosing the sex of adult human by anatomical and morphological features of arytenoid cartilages." Russian Journal of Forensic Medicine 7, no. 2 (2021): 83–87. http://dx.doi.org/10.17816/fm392.

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Background: One of the main issues of general personality identification is the ascertainment of the sex of impersonated or fragmented bodies. Sporadic studies in the forensic medical literature have reported larynx cartilage sexual dimorphism, among which arytenoid cartilages are absent. The publications have morphometric focus and do not consider the practical aspects of sex diagnostics, which have been determined in this study. Aim: To develop a method for determining sex using the features of sexually dimorphic anatomical and morphological arytenoid cartilage of an adult. Materials and met

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Gaivoronsky, I. V., O. M. Fandeyeva, G. I. Nichiporuk, and M. G. Gaivoronskaya. "Comparative characteristics of the methods for determining the somatic sex of an adult person with the use of a skull." Bulletin of the Russian Military Medical Academy 20, no. 3 (2018): 207–13. http://dx.doi.org/10.17816/brmma12360.

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The analysis of Russian and foreign literature on the definition of somatic sex on the skull is presented. Cranioscopic and craniometric approaches are considered in carrying out craniological studies and existing traditional and modern methods for their implementation. Cranioscopic studies reveal the advantages and disadvantages of W.M. Krogman, G. Acsadi, J. Nemeskeri and V.N. Zvyagina methods. It is shown that the method of V.N. Zvyagina, which includes 40 descriptive diagnostic signs, is the most informative. Its efficiency is 93,5%. The comparative analysis of the craniometric methods for

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van Bolhuis, Hester, Lotte van Hoffen, Martine van Zijll Langhout, et al. "Prevalence of dental disorders in degus and evaluation of diagnostic methods to determine dental disease and its prognosis." Veterinary Record 181, no. 23 (2017): 627. http://dx.doi.org/10.1136/vr.104253.

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Degus (Octodon degus) are prone to develop dental disease with deleterious health effects. The two studies reported here aimed to determine the prevalence of dental disorders in degus and to identify and evaluate diagnostic tools for determination of prognosis of these disorders. In study A, health data from 225 degus at AAP, Rescue Center for Exotic Animals in the Netherlands, were collated and the prevalence of dental disorders and differences in sex and age at clinical onset of symptoms associated with dental disorders were described. The prevalence was 34.7 per cent and higher (P<0.01)

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Addai-Mensah, Otchere, Edward Y. Afriyie, Samuel Asamoah Sakyi, et al. "Fetal Rhesus D Genotyping and Sex Determination from Maternal Plasma of Rhesus D-Negative Antenatal Population: The Usefulness of Conventional Polymerase Chain Reaction in Resource-limited Settings." Obstetrics and Gynecology International 2020 (October 16, 2020): 1–6. http://dx.doi.org/10.1155/2020/4913793.

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Background. This prospective cohort study evaluated the usefulness of conventional PCR in genotyping fetal Rhesus D (RhD) and sex from the maternal plasma of RhD-negative (RhD−) antenatal population in resource-limited settings. Methods. Thirty apparently healthy RhD− pregnant women with RhD positive (RhD+) partners were included. Blood samples were collected from each participant (in the third trimester of pregnancy) for DNA extraction/purification and fetal RhD genotyping. Results. Out of the 30 samples, 26 (86.7%) were found to be RhD+ while 4 (13.3%) were RhD−. The RhD+ comprised 24 (80.0%

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Rud, Yu, and I. Grytsyniak. "Sex Determination Systems Based on PCR for Salmonids Reared in Ukraine." Agricultural Science and Practice 1, no. 3 (2014): 37–42. http://dx.doi.org/10.15407/agrisp1.03.037.

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Aims. To analyse highly conserved male-specifi c sequences in Y chromosome of salmonid species and de- velop the conventional polymerase chain reaction (PCR) for rapid identifi cation of fi sh sex. Methods. DNA sequence analysis, phylogenetic analysis, DNA extraction, primers design, PCR and sequencing were used. Results. Using the data from NCBI GenBank, all available sequences of male-specifi c Y-chromosome genes (sdY) in salmonid species were analyzed for specifi c oligonucleotide primer design. The PCR assay for rapid identifi cation of males in rainbow trout Onchorhynchus mykiss, brown tr

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9

Schnell-Inderst, P., D. Noßke, M. Weiss, et al. "Aquisition of age- and sex-dependent patient data for the calculation of annual radiation exposure in nuclear medicine: a German pilot study." Nuklearmedizin 43, no. 02 (2004): 45–56. http://dx.doi.org/10.1055/s-0038-1625591.

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Summary Aim: A pilote study for estimation of radiation exposure due to diagnostic procedures in nuclear medicine using routine data of hospitals and practices in Germany. Methods: Hospitals and practices willing to participate in the study supplied data of one year (1997), containing information on patients´ identification number, age, sex, type of diagnostic procedure, radiopharmaceutical, administered activity, type of health insurance (private/ public), inpatient/outpatient status, and so-called Leistungsziffer, which describes the type of medical performances in Germany. The effective dos

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Jahan, Sharmin, Muhammad Abul Hasanat, Fakhrul Alam, Mohammad Fariduddin, and Tania Tofail. "LEYDIG CELL HYPOPLASIA: A UNIQUE PARADOX IN THE DIAGNOSIS OF 46,XY DISORDERS OF SEX DEVELOPMENT." AACE Clinical Case Reports 6, no. 3 (2020): e117-e122. http://dx.doi.org/10.4158/accr-2019-0152.

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Objective: Disorders of sex development (DSD) are defined as conditions in which chromosomal sex is inconsistent with phenotypic sex, or in which the phenotype is not classifiable as either male or female. Mutations in genes present in X, Y or autosomal chromosomes can cause abnormalities of testis determination or 46,XY DSD. Leydig cell hypoplasia (LCH), also known as Leydig cell agenesis, is a rare autosomal recessive endocrine syndrome of 46,XY DSD. Our objective here is to present the case of a 27-year-old, phenotypic female who presented with primary amenorrhea and later found to have LCH

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Dreksler, Adam, Marcin Lenkowski, Michał Marcinkowski, et al. "A 10 year data analysis of lymphatic system metastasis and recurrence in individuals affected by malignant tumors within the oral cavity and maxillofacial region." Journal of Medical Science 84, no. 3 (2015): 141–45. http://dx.doi.org/10.20883/medical.e10.

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Introduction. Tumors are only second to cardiovascular diseases as a cause of death. According to World Health Organization (WHO), these statistics will increase especially within aging and well-developed countries.Aim. The aim of the research was to analyze the frequency of recurrences and lymph node involvement in individuals affected by malignant tumor of head and neck region. Special attention was paid to tumor location, sex, age of the affected individuals as well as histological appearance of the tumor.Material and methods. The research team has analyzed medical data record base from 200

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Stamenkovic, Bojana, Aleksandra Stankovic, Aleksandar Dimic, et al. "The clinical significance of antibody determination to cyclic citrullinated peptides in systemic sclerosis." Srpski arhiv za celokupno lekarstvo 140, no. 5-6 (2012): 350–54. http://dx.doi.org/10.2298/sarh1206350s.

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Introduction. Anti-citrullinated peptides antibodies (ACPA) are present in 80% of sera of rheumatoid arthritis (RA) patients with high specificity for diagnosis and prediction for the development of early erosive arthritis. A few studies have reported a low frequency ACPA in systemic sclerosis (SSc) patients with the presence of arthritis. Objective. The aim of our study was to determine the frequency of ACPA in systemic sclerosis (SSc) patients, their correlation with clinical manifestations and radiographic features. Methods. The study included 82 patients with SSc, mean age 54.4 years, 59 w

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Wong, Cynthie, Maya Thangavelu, Michele Hibbard, Forrest Blocker, Lawrence M. Weiss, and Vincent Anthony Funari. "Comparison of diagnostic methodologies to detect chromosomal abnormalities." Journal of Clinical Oncology 37, no. 15_suppl (2019): e14617-e14617. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e14617.

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e14617 Background: Traditional technologies such as cytogenetics, FISH, and microarray (CGH) are utilized in most clinical laboratories. Next-Generation Sequencing (NGS) is a relatively new tool to evaluate the cancer genome. Applications of this method include assessing single nucleotide variants (SNVs), indel mutations, and copy number variations (CNVs), including some large chromosomal deletions or gains. Methods: We used a custom Discovery+LOH NGS panel (Agilent, Santa Clara) to determine the utility of NGS in detecting CNV and loss of heterozygosity (LOH) events. Thirty six patients with

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Maas, Mark S., Karen E. Moeller, and Brittany L. Melton. "Determination of combination therapy prescribing patterns for the treatment of acute agitation in psychiatric patients: A regression model of patient diagnoses and demographics." Mental Health Clinician 9, no. 5 (2019): 298–303. http://dx.doi.org/10.9740/mhc.2019.09.298.

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Abstract Introduction Guidelines for the treatment of acute agitation typically recommend monotherapy with an antipsychotic or a benzodiazepine, but combination therapy is frequently used in practice. We created a regression model to identify which factors lead to the prescribing of combination therapy for acute agitation on a psychiatry unit. Methods We collected retrospective data from hospitalized patients in the psychiatry unit. An a priori alpha of 0.05 was used for binary logistic regression models to determine if and how the number of prescribed medications for acute agitation was influ

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Paiva, Aldair Sousa, Hugo Diogenes De Oliveira Paiva, Geraldo Barroso Cavalcanti, et al. "Contribution of Flow Cytometry Immunophenotyping in Diagnostic of Acute and Chronic Leukemias." Blood 132, Supplement 1 (2018): 5198. http://dx.doi.org/10.1182/blood-2018-99-118923.

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Abstract BACKGROUND: Today immunophenotyping by flow cytometry is an useful adjunct to cytomorphologyc analysis to correct diagnostic of leukemias. It provides objective and quantitative data allowing for a high level of sensitivity detection and better characterization of acute and chronic leukemias. The purpose of this study was to demonstrate the contribution of the immunophenotyping by monoclonal antibodies (Mo.Ab.) in leukemic cells from patients with acute and chronic leukemias. METHODS: Analyzed 76 patients with leukemias before the treatment. The diagnostic of leukemias was based on th

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SCHMIDT-RHAESA, ANDREAS. "Considerations on the genus Gordius (Nematomorpha, horsehair worms), with the description of seven new species." Zootaxa 2533, no. 1 (2010): 1. http://dx.doi.org/10.11646/zootaxa.2533.1.1.

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Specimens belonging to the genus Gordius (horsehair worms, Nematomorpha) are comparatively poor in diagnostic characters and determination of species is difficult. The characters important for determination (coloration, size, shape of anterior and posterior end, structures in the male posterior end, cuticular structure) are discussed. From the 119 species of the genus, 40 are regarded as invalid. The remaining 79 species and their characters are summarized in a table. The species Gordius aquaticus is the best known name among nematomorphs, but its diagnostic characters are critically reviewed.

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Edmond, Tyler, Alexandra Laps, Alexandria L. Case, Nathan O’Hara, and Joshua M. Abzug. "Normal Ranges of Upper Extremity Length, Circumference, and Rate of Growth in the Pediatric Population." HAND 15, no. 5 (2019): 713–21. http://dx.doi.org/10.1177/1558944718824706.

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Background: Upper extremity length and circumference abnormalities are present in a number of conditions in the pediatric population. In most cases, upper limb hypoplasia and hypertrophy are diagnosed when one limb appears substantially different from the other during physical examination. However, occasionally when this discrepancy exists, it can be difficult to determine which limb is the abnormal one. The purpose of this study was to establish normal values for upper extremity length, circumference, and rate of growth in children aged 0 to 17 years. Methods: In all, 377 participants had 4 m

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Bibik, Mykhailo, Hryhorii Moroz, Vitalii Kyrylenko, and Artem Kuzmenko. "The problem of the alkalinity degree diagnostics in the soils of the northwest of the Black sea region." Visnyk of the Lviv University. Series Geography, no. 51 (December 27, 2017): 21–32. http://dx.doi.org/10.30970/vgg.2017.51.8734.

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According to the results of the study of soils in the Northwest of the Black Sea region, it is determined that here, in the profile of vorony-calcic and calcic Chernozems, both residual and weak alkalinity are manifested. It was found out, nowadays, in the national soil science, there are no clear criteria for the selection of sodic soils and for the determination of their alkalinity degree. Furthermore, there is also the question of the differentiation of the actually sodic and residual-sodic soils. It has been established that on the territory of the Northwest of the Black Sea region polygen

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Aydin, Kader Cesur, Oğuzhan Demirel, Gülay Altan Salli, and Mutlu Özcan. "Evaluation of Two Dental Digital Imaging Systems Based on Quality Scorings, Burn-Out Effects and Cervical Width Determination." Balkan Journal of Dental Medicine 24, no. 2 (2020): 71–76. http://dx.doi.org/10.2478/bjdm-2020-0012.

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SummaryBackground/Aim: The aim of the present study is to evaluate diagnostic accuracy of two generic image receptors with CMOS and PSP sensors for image quality scoring (IQS), burnout incidences (BI) and cervical widths (CW) with regard to four different exposure times.Material and Methods: 43 incisor teeth within 15 paraffin block models were exposed at 4 different exposure times both for the CMOS and PSP groups, and a total number of 120 images were obtained. All images were evaluated by 3 dentomaxillofacial radiologists via 3 different criteria; IQS, BI, CW.Results: Diagnostic quality scor

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Madani, Gisma Ahmed, Kamal Eldin Badawi, Helen Suban Mohammed Gouse, and Suban Mohammed Gouse. "Anatomical variations of the middle Turbinate among adult Sudanese Population -A Computed Tomographic Study." Bangladesh Journal of Medical Science 20, no. 1 (2021): 62–67. http://dx.doi.org/10.3329/bjms.v20i1.50347.

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Objectives: This study aimed to determine the prevalence of the anatomical variations of themiddle turbinate among adult Sudanese population which include Concha Bullosa (CB) andParadoxical middle turbinate (PMT) and their relationship with age and sex. Methods: The studypopulation involved 29 males (47.5%) and 32 females (52.5 %) with a mean age of 37 years.Exploration was done in the radio-diagnostic department of Ribat University Teaching Hospital,Khartoum- Sudan in the period from January to September 2018. Patients were scanned on slicecollimation of 1mm thickness with a slice thick

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Wu, Zehua, Huabin Hu, and Yanhong Deng. "Association of HER2 expression with pathologic features and prognosis in stage II and III colon cancer." Journal of Clinical Oncology 39, no. 15_suppl (2021): 3524. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.3524.

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3524 Background: We examined the frequency, tumor characteristics, and prognostic impact of HER2 protein expression in stage II and III colon cancer after curative resection. Methods: Paraffin-embedded tumors from consecutive primary stage II and III colon cancer patients were analyzed for HER2 protein expression by immunohistochemistry between April, 2013 and May, 2020. HER2 determination of immunohistochemistry scores (0/1+/2+/3+) was according to HERACLES diagnostic criteria. Results: A total of 2088 stage II and III colon cancer patients were included (53.8% stage II, 46.3% stage III). HER

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Khashchenko, Elena, Elena Uvarova, Mikhail Vysokikh, et al. "The Relevant Hormonal Levels and Diagnostic Features of Polycystic Ovary Syndrome in Adolescents." Journal of Clinical Medicine 9, no. 6 (2020): 1831. http://dx.doi.org/10.3390/jcm9061831.

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Relevance: The clinical picture of polycystic ovary syndrome (PCOS) is extremely polymorphic, especially in adolescence. At the same time, the diagnostic criteria of PCOS in adolescence are still under discussion, and the hormonal parameters, including anti-Mullerian hormone range and hyperandrogenism, are not determined. The aim of the present study was to characterize the pivotal clinical and hormonal features of PCOS in adolescents and to establish the age-specific thresholds of the most essential hormonal parameters. Design: A case-control study. Methods: The study included 130 girls with

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Koumbaris, George, Elena Kypri, Kyriakos Tsangaras, et al. "Cell-Free DNA Analysis of Targeted Genomic Regions in Maternal Plasma for Non-Invasive Prenatal Testing of Trisomy 21, Trisomy 18, Trisomy 13, and Fetal Sex." Clinical Chemistry 62, no. 6 (2016): 848–55. http://dx.doi.org/10.1373/clinchem.2015.252502.

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Abstract BACKGROUND There is great need for the development of highly accurate cost effective technologies that could facilitate the widespread adoption of noninvasive prenatal testing (NIPT). METHODS We developed an assay based on the targeted analysis of cell-free DNA for the detection of fetal aneuploidies of chromosomes 21, 18, and 13. This method enabled the capture and analysis of selected genomic regions of interest. An advanced fetal fraction estimation and aneuploidy determination algorithm was also developed. This assay allowed for accurate counting and assessment of chromosomal regi

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AL-Salman, H. N. K., Ekhlas Qanber Jasim, and Hussein H. Hussein. "Theophylline Determination in Pharmaceuticals Using a Novel High-performance Liquid Chromatographic Process." NeuroQuantology 19, no. 7 (2021): 196–208. http://dx.doi.org/10.14704/nq.2021.19.7.nq21103.

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Objective: The current study aims to find a suitable, accurate, and faster RP-HPLC technique for the determination of theophylline, which could then be validated in accordance with the International Conference on Harmonization (ICH) guidelines. The Aim of this Study: The aim of this study was to develop an efficient, accurate, and faster RP-HPLC method for determining theophylline, which was then validated using the International Conference on Harmonization (ICH) guidelines. Methods: In the HPLC analysis, the Waters 2695 was used. The drug was isolated better using an Ion Pac zorbax 300-SCX Ag

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Gaudenzi, Giulia, Elias Kumbakumba, Reza Rasti, et al. "Point-of-Care Approaches for Meningitis Diagnosis in a Low-Resource Setting (Southwestern Uganda): Observational Cohort Study Protocol of the “PI-POC” Trial." JMIR Research Protocols 9, no. 11 (2020): e21430. http://dx.doi.org/10.2196/21430.

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Background A timely differential diagnostic is essential to identify the etiology of central nervous system (CNS) infections in children, in order to facilitate targeted treatment, manage patients, and improve clinical outcome. Objective The Pediatric Infection-Point-of-Care (PI-POC) trial is investigating novel methods to improve and strengthen the differential diagnostics of suspected childhood CNS infections in low-income health systems such as those in Southwestern Uganda. This will be achieved by evaluating (1) a novel DNA-based diagnostic assay for CNS infections, (2) a commercially avai

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Paiva, Aldair Sousa, Alessandra Suelen Jardim, Victor lima Soares, et al. "The Diagnostic Value of Kappa/Lambda Ratios Determined By Flow Cytometric Analysis of Peripheral Blood and Bone Marrow Specimens in B-Cell Chronic Proliferative Disease." Blood 132, Supplement 1 (2018): 5431. http://dx.doi.org/10.1182/blood-2018-99-119868.

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Abstract Background. Previous studies have suggested that analysis of the distribution of surface immunoglobulin light chain kappa and lambda by flow cytometry (FC) provides evidence for monoclonality of B cell tumors in patients with persistent lymphocytosis. The objective is this study is to investigate the efficiency of FC in determination of monoclonality in patients with persistent lymphocytosis through the analysis of kappa and lambda light chain of immunoglobulin expression (kappa/lambda tests). Methods: Samples of peripheral blood from 43 patients with B-CLD were analyzed. They were an

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Perrault, Justin R., Michael D. Arendt, Jeffrey A. Schwenter, Julia L. Byrd, Kathryn A. Tuxbury, and Nicole I. Stacy. "Comparison of 2 glucose analytical methodologies in immature Kemp’s ridley sea turtles: dry chemistry of plasma versus point-of-care glucometer analysis of whole blood." Journal of Veterinary Diagnostic Investigation 33, no. 3 (2021): 595–99. http://dx.doi.org/10.1177/10406387211001830.

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Blood glucose measurements provide important diagnostic information regarding stress, disease, and nutritional status. Glucose analytical methodologies include dry chemistry analysis (DCA) of plasma and point-of-care (POC) glucometer analysis of whole blood; however, these 2 methods differ in cost, required sample volume, and processing time. Because POC glucometers use built-in equations based on features of mammalian blood to convert whole blood measurements to plasma equivalent units, obtained glucose data must be compared and validated using gold-standard chemistry analytical methodology i

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Reinsberg, Jochen, Jörg Dembinski, Christoph Dorn, Daniela Behrendt, Peter Bartmann, and Hans van der Ven. "Determination of Total Interleukin-8 in Whole Blood after Cell Lysis." Clinical Chemistry 46, no. 9 (2000): 1387–94. http://dx.doi.org/10.1093/clinchem/46.9.1387.

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Abstract Background: It has been shown that a high percentage of interleukin-8 (IL-8) in blood is cell associated. Recently, a simple method for determination of cell-associated IL-8 in whole blood after cell lysis has been described. The purpose of this study was to evaluate this method, to examine the influence of preanalytic sample handling, and to establish the concentration range of total IL-8 and its relation to age and sex in healthy subjects. Methods: Total IL-8 content of whole blood was determined after lysing blood cells with Milenia® cell lysis solution. IL-8 in the resulting blood

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Parnami, Priyanka, Deepak Gupta, Vishal Arora, Saurabh Bhalla, Adarsh Kumar, and Rashi Malik. "Assessment of the Horizontal and Vertical Position of Mental Foramen in Indian Population in Terms of Age and Sex in Dentate Subjects by Pano-ramic Radiographs: A Retrospective Study with Review of Literature." Open Dentistry Journal 9, no. 1 (2015): 297–302. http://dx.doi.org/10.2174/1874210601509010297.

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Objective : To familiarize new criteria to access vertical position of mental foramen in panoramic radiographs. Furthermore, to determine and compare the position and symmetry of mental foramen in horizontal as well as in vertical plane in Indian population and to compare the results with those reported for other populations in the literature. Further gender differences in mental foramen position were also accessed to comment on the reliability of panoramic radiographs for sex determination. Methods and Material : Six hundred digital panoramic radiographs were selected and studied regarding th

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Calistri, D., C. Rengucci, A. Casadei-Gardini, et al. "FL-DNA approach for noninvasive early diagnosis of colorectal cancer in FOBT-screened patients." Journal of Clinical Oncology 27, no. 15_suppl (2009): 11062. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.11062.

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11062 Background: A promising approach for the early diagnosis of colorectal cancer (CRC) is the evaluation of genomic DNA integrity (FL-DNA) extracted from stool. Pilot and confirmatory studies carried out by our group have shown that, thanks to its diagnostic accuracy, this molecular assay could be a useful tool for the non-invasive, early diagnosis of CRC. The aim of the present study was to verify whether the FL-DNA method could represent a valid alternative to the fecal occult blood test (FOBT) or whether it could be used alongside FOBT in screening programs to unmask false FOBT positives

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Levkova, Margarita, Alina Misjura, Evgeny Gusinets, Margarita Levkova, Alina Misyura, and Evgeny Gusinets. "DETERMINATION OF SENIOR PRESCHOOLERS' LEVEL OF THE COGNITIVE COMPONENT OF PERSONAL PHYSICAL CULTURE." Sports Bulletin of the Dnieper 1 (2020): 289–97. http://dx.doi.org/10.32540/2071-1476-2019-1-289.

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Physical education is the main objective of physical education in preschool educational institutions of the Republic of Belarus. This is an integral part of the successful improvement of a diversified personality, both in the field of physical culture and in the connection with other areas of life. In this regard, the issue of increasing the level of formation of physical education knowledge, an integral part of the cognitive component of personal physical education, is currently very relevant in the education system at all its levels. The modern system of preschool and general secondary educa

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Schneider, David A., Jan Backman, William B. Curry, and Göran Possnert. "Paleomagnetic Constraints on Sedimentation Rates in the Eastern Arctic Ocean." Quaternary Research 46, no. 1 (1996): 62–71. http://dx.doi.org/10.1006/qres.1996.0044.

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Deep-sea sediments recovered from six sites visited during the International Arctic Ocean Expedition of 1991 were examined to determine sedimentation rates in the eastern Arctic Ocean basin. The dearth of age-diagnostic biogenic material in these sediments precludes the application of biostratigraphic methods, but ages can be deduced using paleomagnetism, in conjunction with measurements of radiocarbon and carbonate concentration. Although no one of these techniques gives an unambiguous determination of age, the interpretation most consistent with these diverse data implies that sedimentation

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Brik, Alexander, Daniel G. Weber, Swaantje Casjens, et al. "Digital PCR for the Analysis of MYC Copy Number Variation in Lung Cancer." Disease Markers 2020 (September 21, 2020): 1–8. http://dx.doi.org/10.1155/2020/4176376.

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Background. MYC (v-myc avian myelocytomatosis viral oncogene homolog) is one of the most frequently amplified genes in lung tumors. For the analysis of gene copy number variations, dPCR (digital PCR) is an appropriate tool. The aim of our study was the assessment of dPCR for the detection of MYC copy number variations (CNV) in lung tissue considering clinicopathological parameters. Material and Methods. MYC status was analyzed with dPCR as well as qPCR (quantitative PCR) using gDNA (genomic DNA) from tumor and adjacent nontumor tissue samples of lung cancer patients. The performance of MYC was

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Walker, Evan Justin, Amie Blanco, Julia C. Carnevale, et al. "The marginal diagnostic benefit of pancreatic cancer molecular profiling after germline testing." Journal of Clinical Oncology 39, no. 15_suppl (2021): 10513. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.10513.

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10513 Background: Germline genetic testing is now universally recommended for patients (pts) with pancreatic ductal adenocarcinoma (PDAC) for purposes of both familial screening and therapeutic guidance. Treatment selection can be further informed by tumor molecular profiling (TMP) to identify targetable somatic alterations in pts with advanced disease, but this is inconsistently applied. Determination of the rate of actionable findings identified with TMP after germline testing, which we term marginal diagnostic benefit, may inform practice patterns and workflow in this patient population. Me

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Harris-Love, Michael O., Bryant A. Seamon, Carla Teixeira, and Catheeja Ismail. "Ultrasound estimates of muscle quality in older adults: reliability and comparison of Photoshop and ImageJ for the grayscale analysis of muscle echogenicity." PeerJ 4 (February 22, 2016): e1721. http://dx.doi.org/10.7717/peerj.1721.

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Background.Quantitative diagnostic ultrasound imaging has been proposed as a method of estimating muscle quality using measures of echogenicity. The Rectangular Marquee Tool (RMT) and the Free Hand Tool (FHT) are two types of editing features used in Photoshop and ImageJ for determining a region of interest (ROI) within an ultrasound image. The primary objective of this study is to determine the intrarater and interrater reliability of Photoshop and ImageJ for the estimate of muscle tissue echogenicity in older adults via grayscale histogram analysis. The secondary objective is to compare the

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Osokina, A. V., V. N. Karetnikova, O. M. Polikutina, et al. "N-terminal propeptide of type III procollagen for predicting diastolic dysfunction in patients with myocardial infarction and preserved ejection fraction." Cardiovascular Therapy and Prevention 20, no. 1 (2021): 2494. http://dx.doi.org/10.15829/1728-8800-2021-2494.

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Aim. To study changes in the level of fibrotic scarring marker — the N-terminal propeptide type III procollagen (PIIINP) and structural and functional parameters with the assessment of diastolic function in patients a year after ST segment elevation myocardial infarction (STEMI) and preserved left ventricle (LV) contractility.Material and methods. At first, the study included 120 (100%) STEMI patients. Next, patients with an LV ejection fraction (EF) ≥50% were selected. The final analysis included 86 STEMI patients. Upon hospitalization, the patients underwent routine diagnostic tests, coronar

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Moroydor Derun, Emek, and Fatma Tugce Senberber. "Characterization and Thermal Dehydration Kinetics of Highly Crystalline Mcallisterite, Synthesized at Low Temperatures." Scientific World Journal 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/985185.

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The hydrothermal synthesis of a mcallisterite (Mg2(B6O7(OH)6)2·9(H2O)) mineral at low temperatures was characterized. For this purpose, several reaction temperatures (0–70°C) and reaction times (30–240 min) were studied. Synthesized minerals were subjected to X-ray diffraction (XRD), fourier transform infrared (FT-IR), and Raman spectroscopies and scanning electron microscopy (SEM). Additionally, experimental analyses of boron trioxide (B2O3) content and reaction yields were performed. Furthermore, thermal gravimetry and differential thermal analysis (TG/DTA) were used for the determination of

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Virseda, Alvaro, Juan Luis Garcia, Sara Marcos Asensio, et al. "Determination of AR-V7 in plasma in patients with metastatic prostate cancer using capillary Nano-immunoassay." Journal of Clinical Oncology 37, no. 15_suppl (2019): e16574-e16574. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e16574.

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e16574 Background: Liquid biopsy has the potential to provide information about cancers without invasive biopsy, using circulating biomarkers. The aim of present study was determinate the presence of androgen receptor splice variant 7 (AR-V7) in plasma using capillary nano-immunoassay in metastasis PCa and correlation with clinical and analytical data. Methods: Whole blood (10 ml) was collected and processed in EDTA tubes. Previously to determinate the presence of ARV-7 in plasma Capillary Electrophoresis Immunoassay or SimpleWestern analyses were performed using the WES™ machine. With this te

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Abdulhussein, Layth Taha, Dr Mohammed Abdullatif, and Dr Aref Sami Malik. "Assessment of Serum L-Ficolin Level as Inflammatory Marker and Its Correlation with Serum C-Reactive Protein, D-Dimer and Ferritin in a Sample of Iraqi COVID-19 Patients." Journal of University of Shanghai for Science and Technology 23, no. 08 (2021): 107–16. http://dx.doi.org/10.51201/jusst/21/08347.

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Subject: At the end of December 2019, a COVID-19 outbreak was reported for the first time in Wuhan, China. Which quickly expanded throughout China, then to 209 nations across America, Europe, Australia, and Asia. More than 50,000 people have died and over one million individuals have been afflicted worldwide, with the number fast rising. COVID-19 has been combated in various ways around the world. The gold standard for COVID-19 diagnosis is real-time fluorescence quantitative reverse transcriptase polymerase chain reaction (reverse transcriptase-polymerase chain reaction, RT-PCR) and viral gen

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Shegaonkar, Akash, Shilpa Patel, Niharika Swain, Jigna Pathak, Rashmi Hosalkar, and Rutuj Waghmare. "Evaluation and Correlation of Clinicopathological Parameters of Oral Squamous Cell Carcinoma of Gingivobuccal Sulcus with Lymph Node Status - A Retrospective Institutional Analysis in Navi Mumbai." Journal of Evolution of Medical and Dental Sciences 10, no. 30 (2021): 2294–99. http://dx.doi.org/10.14260/jemds/2021/469.

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BACKGROUND Mortality and Morbidity rates in the patients diagnosed with oral cancers remain static despite availability of advanced diagnostic and treatment modalities. For improving the survival status of the patients, a thorough understanding of the factors that predicts the progression of oral cancer is necessary to determine appropriate line of treatment. To do so in practise, critical knowledge regarding the prognostic factors that has high sensitivity holds immense importance. For determination of prognosis in oral cancer patients, clinical and histopathological parameters are widely use

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Gandikota, Neetha, Su Ann Ng, Ryan Cotter, et al. "A combined evaluation strategy of FDG PET/CT and contrast-enhanced diagnostic CT (ceCT) for lymph nodes in the neck." Journal of Clinical Oncology 30, no. 15_suppl (2012): 5578. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.5578.

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5578 Background: Accurate assessment of cervical lymph nodes (LNs) for determination of metastatic involvement is of prime importance for management. Our objective was to determine the incremental value of combining metabolic and morphologic information in the differentiation between benign and malignant LNs. Methods: A total of101 pts with head and neck squamous cell (n=91) or thyroid cancer (n=6) or lymphoma (n=4) were included in the study. PET/CT and neck ceCT were acquired simultaneously or sequentially at staging (n=48) or restaging (n=53). In 131 LNs, variables evaluated includes SUVmax

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Suhartiningtyas, Dwi, Bernadeta Esti Chrismawaty, Dewi Agustina, and Goeno Subagyo. "Toluidine Blue Vital Staining sebagai Alat Bantu Diagnostik pada Karsinoma Sel Skuamosa Lidah." Majalah Kedokteran Gigi Indonesia 19, no. 2 (2012): 136. http://dx.doi.org/10.22146/majkedgiind.15535.

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Latar belakang. Karsinoma sel skuamus oral (KSSO) merupakan salah satu kanker mulut yang paling sering terjadi. Deteksi dini kanker mulut menyulitkan oleh karena etiologi yang tidak pasti dan gambaran klinis yang tidak khas. Toluidine blue vital staining (TBVS) dilaporkan dapat membantu penegakan diagnosis KSSO. Tujuan. Penulisan ini bertujuan melaporkan kasus KSSO di lidah yang terdiagnosis melalui TBVS. Kasus dan penanganannya. Laki-laki 77 tahun dengan gigi tiruan lengkap mengeluhkan sakit pada lidah sejak 2 minggu lalu, yang tidak sembuh dengan terapi konvensional. Pasien adalah perokok be

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Radchenko, A. O., and O. V. Kolesnikova. "ASSOCIATION BETWEEN OF ANTIOXIDANT PROTECTION WITH CHRONOLOGICAL AND BIOLOGICAL AGE IN PATIENTS WITH ARTERIAL HYPERTENSION." Medical Science of Ukraine (MSU) 17, no. 2 (2021): 53–58. http://dx.doi.org/10.32345/2664-4738.2.2021.08.

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Relevance. The study is relevant due to the increase in the prevalence of arterial hypertension (AH) with age, as well as the presence of common developmental mechanism with aging processes, that is a violation of antioxidant protection. Given the changes in the antioxidant state with age, studying their relationship with biological age (BA) may be useful in this category of patients. Objective: to study changes in antioxidant status in AH patients of various age categories and their relationship with calendar age (CA) and BA, calculated using two outpatient methods. Materials and

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Rozina, I. V. "PECULIARITIES OF THE SANDPLAY THERAPY APPLICATION IN DEALING WITH AGGRESSION IN TEENAGE YEARS." Herald of Kiev Institute of Business and Technology 43, no. 1 (2020): 13–19. http://dx.doi.org/10.37203/kibit.2020.43.02.

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The actuality of the research is connected with the necessity of studying psychological peculiarities of aggression manifestation in teenage years, which is not studied sufficiently enough and requires a more thorough research, namely, the development of the program aimed at decreasing the level of the aggression manifestation with the use of methods of the sandplay therapy. The article presents the theoretical analysis of the contemporary methods in psychology for investigating aggression in the teenage years. Furthermore, the types of aggression, factors contributing to the occurrence the te

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Charinzeva, Svetlana V., and Elizaveta S. Taskina. "The role of interleukins 17, 23 and antibodies to the thyroid-stimulating hormone receptor in the pathogenesis of endocrine ophthalmopathy." Clinical and experimental thyroidology 14, no. 2 (2018): 72–80. http://dx.doi.org/10.14341/ket9703.

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Background. Endocrine ophthalmopathy (EOP) is an autoimmune orbit disease characterized by soft retrobulbar tissues damage. The level of antibodies to the thyroid-stimulating hormone receptor (TSHRAbs) is considered as a laboratory marker of EOP activity. Interleukins 17 (IL-17) and 23 (IL-23) play an important role in the pathogenesis of some autoimmune diseases and directly correlate with clinical activity. At present, there is an open question about the role of these cytokines in EOP and their relationship with TSHRAbs. Aims. To assess pathogenetic role of IL-17, IL-23 and TSHRAbs in

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Grigorian, O. M., L. F. Sklyar, O. V. Filipova,, E. V. Gavro, S. N. Beniova та M. Yu Shchelkanov. "Human papilloma virus in the urethra in HIV-infected men in the Рrimorsk region". HIV Infection and Immunosuppressive Disorders 13, № 1 (2021): 28–36. http://dx.doi.org/10.22328/2077-9828-2021-13-1-28-36.

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Objective of the study: identification of HPV and identification of the most common types in urethral swabs taken from HIV-1- infected men, as well as determination of the dependence of the presence of HPV in patients with HIV viral load (VL) and CD4 + T-lymphocyte count.Materials and methods. The study included 34 HIV-1-infected men being monitored at the Center for the Prevention and Control of AIDS and Infectious Diseases (Vladivostok). They were asked to undergo a urological examination, including the collection of urethral swabs, as well as a face-to-face interview to collect socio-demogr

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Narine, Nadira, Bensita M. V. Thottakam, Alessia Donnini, et al. "Role of MCM as an adjuvant to urine cytology in the diagnosis of bladder cancer." Journal of Clinical Oncology 30, no. 15_suppl (2012): e15011-e15011. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e15011.

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e15011 Background: Urine cytology, a cheap non invasive first line test (PAP) has traditionally been used for the diagnosis of urothelial carcinoma (UC) as it has excellent sensitivity for the detection of high grade and in situ lesions. However, sensitivity for low grade carcinoma is rather varied as this is a problematic area with various mimics leading to both over and under diagnoses. To overcome this dilemma, a number of biomarkers and molecular tests have been employed with mixed results and varied financial implications. We report on a relatively cheap and easily adopted in vitro diagno

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Jamsari, A., I. Nitz, S. M. Reamon-Büttner, and C. Jung. "BAC-derived diagnostic markers for sex determination in asparagus." Theoretical and Applied Genetics 108, no. 6 (2003): 1140–46. http://dx.doi.org/10.1007/s00122-003-1529-0.

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Hill, Brian T., Angela M. B. Collie, Tomas Radivoyevitch, Eric D. Hsi, and John Sweetenham. "Cell of Origin Determination in Diffuse Large B-Cell Lymphoma: Performance of Immunohistochemical (IHC) Algorithms and Ability to Predict Outcome." Blood 118, no. 21 (2011): 950. http://dx.doi.org/10.1182/blood.v118.21.950.950.

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Abstract Abstract 950 INTRODUCTION: Diffuse large B-cell lymphoma (DLBCL) can be categorized by its cell of origin (CoO) as either being derived from a germinal center B-cell (GCB) or activated B-cell (ABC). Primary mediastinal DLBCL represents a third, distinct entity. This classification was initially defined by gene expression profiling (GEP), which remains the gold standard for such determination. Determination of CoO will likely become the basis for patient selection for clinical trials of targeted therapies. Several algorithms and methods have been developed that use immunohistochemistry

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Dmitrieva, Viktoria V., Elena M. Frantsiyants, Irina B. Lysenko, et al. "Activity of thymidine kinase as a prognostic marker of malignant proliferation in adolescents with lymphadenopathy." Journal of Clinical Oncology 37, no. 15_suppl (2019): e19013-e19013. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e19013.

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e19013 Background: Lymphadenopathy presents an important differential diagnostic problem. Thymidine kinase (TK) is an intracellular enzyme catalyzing the conversion of thymidine to thymidine monophosphate in the presence of adenosine triphosphate. TK is the product of certain genes for the progression from G1 through S phase. Determination of serum levels of the first TK isoenzyme is considered to have prognostic significance in malignant proliferation. TK increases significantly in the direct contact of malignant cells with biological fluids such as blood, lymph, or serous effusions, therefor

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