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Wang, P., A. Z. Fu, H. L. Wee, J. Lee, E. S. Tai, J. Thumboo, and N. Luo. "Predicting preference-based SF-6D index scores from the SF-8 health survey." Quality of Life Research 22, no. 7 (October 10, 2012): 1675–83. http://dx.doi.org/10.1007/s11136-012-0284-6.
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Wang, P., N. Luo, HL Wee, ES Tai, J. Lee, and J. Thumboo. "PMC8 PREDICTING THE SF-6D PREFERENCE-BASED INDEX SCORE USING THE SF-8 HEALTH SURVEY." Value in Health 13, no. 7 (November 2010): A552. http://dx.doi.org/10.1016/s1098-3015(11)73312-5.
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Beierlein, Volker, Matthias Morfeld, Corinna Bergelt, Monika Bullinger, and Elmar Brähler. "Messung der gesundheitsbezogenen Lebensqualität mit dem SF-8." Diagnostica 58, no. 3 (July 2012): 145–53. http://dx.doi.org/10.1026/0012-1924/a000068.
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Zusammenfassung. Der Short-Form Health Survey SF-8 ist ein Instrument zur Messung der gesundheitsbezogenen Lebensqualität, einem wichtigen Outcomekriterium klinischer Studien und in den Gesundheitswissenschaften. Das Instrument ist eine Kurzform des häufig verwendeten SF-36, mit dem acht Dimensionen der subjektiven Gesundheit gemessen sowie zwei Summenskalen Körperlicher und Psychischer Gesundheit berechnet werden können. Der SF-8 wurde im Jahr 2004 im Rahmen einer bundesweit durchgeführten Mehrthemenbefragung eingesetzt. Basierend auf diesen Daten können erstmalig repräsentative Normdaten zum SF-8 (N = 2552) aus einer schriftlichen Befragung für die deutsche Bevölkerung vorgelegt werden. Die Referenzdaten werden alters- sowie geschlechtsdifferenziert berichtet und auf Zusammenhänge mit soziodemografischen Merkmalen analysiert. Seltene fehlende Werte in den Antworten weisen auf eine gute Akzeptanz des Instruments hin. Auch wenn der SF-8 in verschiedenen Subskalen mit Deckeneffekten behaftet ist, kann sein Einsatz aufgrund seiner Ökonomie empfohlen werden.
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Majbauddin, Abir, Shinji Otani, Atsushi Tsunekawa, Nigussie Haregeweyn, Misganaw Teshager Abeje, Zerihun Nigussie, Intekhab Alam, Qing Qing, Toshio Masumoto, and Youichi Kurozawa. "The Influence of Income and Livelihood Diversification on Health-Related Quality of Life in Rural Ethiopia." International Journal of Environmental Research and Public Health 17, no. 8 (April 15, 2020): 2709. http://dx.doi.org/10.3390/ijerph17082709.
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Examining health-related quality of life (HRQOL) in a rural setting can be beneficial for improving rural household policies and fostering public health promotion. The objective of this study was to measure the HRQOL and associated socioeconomic characteristics as well as test the reliability of the Amharic version of SF-8 (eight-item short form of HRQOL survey). A cross-sectional study was employed in three agroecologically different sites in rural Ethiopia, involving 270 household heads (218 male and 52 female) with a mean age ± standard deviation of 49 ± 12.88 years. The survey material consisted of a structured questionnaire for socioeconomic characteristics and SF-8 for HRQOL. The mean physical and mental component summary score of the whole sample was 30.50 ± 12.18 and 34.40 ± 7.26, respectively, well underneath the instrument average of 50. The SF-8 items showed excellent internal consistency in terms of both Cronbach’s α coefficients and item–total correlation. In stepwise multiple linear regression, the low-income group had worse self-perceived physical health than the higher-income groups. Likewise, a diversified livelihood had a profound influence on positive self-perceived physical health. These findings imply that developing and distributing wide-ranging socioeconomic and public health policies is crucial for effective health promotion in rural communities.
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Hu, Yu-Whuei, Li-Shan Huang, Eric Yeh, and Mai He. "Healthcare Utilization and Perceived Health Status among Falun Gong Practitioners in Taiwan." Health Behavior and Policy Review 7, no. 6 (2020): 511–31. http://dx.doi.org/10.14485/hbpr.7.6.2.
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Objective: Falun Gong (FLG) is a practice of mind and body focusing on moral character improvement that includes meditative exercises. In this study, we explored perceived health status, healthcare resource utilization, and related factors among Taiwanese FLG practitioners, compared to themselves before practicing FLG, and also to the general Taiwanese norm, as reported by the 2001 National Health Interview Survey (NHIS). Methods: This cross-sectional study was based on a voluntary, paper-based survey conducted from October 2002 to February 2003 using the same Taiwanese SF-36 instrument employed by the NHIS. Primary outcomes included 8 SF-36 domain scores and the number of outpatient visits. One-sample t-tests, oneway ANOVA, and multivariate linear regression analyses were used. Results: The response rate was 75.6% (1210/1600). Compared to the norm, the study cohort had significantly higher scores in 6 of 8 SF-36 domains across sex and age (p < .05). Among those with chronic diseases, 70% to 89% reported that their conditions were improved or cured. Additionally, 74.2% and 79.2% participants stopped drinking alcohol and quit smoking; 62.7% reported decreased outpatient visits (mean before = 11.96; mean after = 5.87; norm = 14.4). Conclusions: In this cohort, FLG participants had higher perceived health scores than the population norm and reduced outpatient visits than before practice.
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Guirado, Vinícius M. P., Mario A. Taricco, Moacyr R. C. Nobre, Euro B. Couto Júnior, Eduardo S. C. Ribas, Alexandre Meluzzi, Roger S. Brock, Mario R. Pena Dias, Rodrigo Rodrigues, and Manoel J. Teixeira. "Quality of life in adult intradural primary spinal tumors: 36-Item Short Form Health Survey correlation with McCormick and Aminoff-Logue scales." Journal of Neurosurgery: Spine 19, no. 6 (December 2013): 721–35. http://dx.doi.org/10.3171/2013.8.spine12706.
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Object The most appropriate method to determine the quality of life of patients with intradural primary spinal tumors (IPSTs) is not still well established. Methods Clinical data in 234 patients who underwent surgery for intradural spinal disease were collected prospectively. The 36-Item Short Form Health Survey (SF-36), a generic score scale, was administered to 148 patients with IPSTs to demonstrate if the survey can be used to effectively evaluate these patients. Forty-eight patients were excluded because they did not complete the protocol. The study was finally conducted with 100 patients (45 male and 55 female) with IPSTs, and the results were compared with those of 2 other scales: the McCormick scale and the Aminoff-Logue scale. Results Construct validity was demonstrated by confirming the hypothesized relationship between the scores of the SF-36 and the McCormick scale (p = 0.003), the Aminoff-Logue gait subscale (p = 0.025), the Aminoff-Logue micturition subscale (p = 0.013), and the Aminoff-Logue defecation subscale (p = 0.004). Reliability was demonstrated for all 8 SF-36 domain scales and the Physical Component Summary and the Mental Component Summary of the SF-36, where in each the Cronbach alpha satisfied the Nunnally criterion of > 0.85. Conclusions The authors' results demonstrated that SF-36 provides valid and reliable data for patients with IPSTs and that the survey can be used appropriately to evaluate these patients.
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Peel, Claire, Carolyn Utsey, and Jan MacGregor. "Exercise Training for Older Adults with Limitations in Physical Function." Journal of Aging and Physical Activity 7, no. 1 (January 1999): 62–75. http://dx.doi.org/10.1123/japa.7.1.62.
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This study aimed to evaluate the effects of an 8-week supervised exercise program on physiological measurements during treadmill walking, muscle strength, functional performance, and health status in older adults limited in physical function. Twenty-four participants were randomly assigned to an exercise group (EG, N = 13) or a control group (CG, N = 11), and were evaluated before and after the exercise program (EG) or 8-week period (CG). Evaluations included a progressive treadmill lest, strength testing, the Physical Performance Test (PPT), and the SF-36 Health Survey. The exercise program consisted of 3 sessions per week of brisk walking and strengthening exercises. The EG demonstrated increases in cardiorespiratory fitness and increases in treadmill walking time. The EG also demonstrated increases in force production in 3 of the 6 muscle groups that were tested. Both the EG and CG demonstrated improvements in PPT scores and in 2 health concepts on the SF-36 Health Survey.
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Emerson, Eric, Roger Stancliffe, Nicola Fortune, and Gwynnyth Llewellyn. "Disability, Loneliness and Health in the UK: cross-sectional survey." European Journal of Public Health 31, no. 3 (May 6, 2021): 533–38. http://dx.doi.org/10.1093/eurpub/ckab018.
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Abstract Background Research has suggested that exposure to loneliness can have a powerful detrimental impact on health, including mental health. Addressing socially determined health inequity requires understanding of the situation of marginalized or vulnerable groups. People with disability are increasingly being recognized as one such group. Little population-based research has addressed the association between loneliness and health among working age adults with and without disability. Methods Secondary analysis of data collected in waves 8 and 9 of Understanding Society, the UK’s main annual household panel study. Results Rates of exposure to substantial loneliness were 25.4% (95%CI 23.5–27.3%) among adults with persistent disability (disability at W8 and W9), 15.4% (13.3–17.5%) among adults with disability onset (disability at W9 only), 12.3% (10.1–14.5%) among adults with disability offset (disability at W8 only), and 6.9% (6.5–7.3%) among adults with no disability. Exposure to loneliness was positively associated with the incidence (GHQ-12) and prevalence (SF-12 Mental) of mental health problems, but not the prevalence of physical health problems (SF-12 Physical). Disability status appeared to moderate the association between loneliness and health, with the difference between the persistent disability and no disability group increasing with exposure to greater levels of loneliness. Conclusion Loneliness may be an important determinant of the poorer mental health of working age adults with disability in the UK. Exposure rates are significantly higher than among the non-disabled population. The strength of association between exposure to loneliness and poorer mental health is greater for people with persistent disability than people with no disability.
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Dubinsky, M. C., A. G. Bushmakin, J. C. Cappelleri, J. Woolcott, P. Sharma, E. Maller, L. Salese, and A. Armuzzi. "P699 The concordance of Short Form-36 Health Survey scores with Mayo scores in the tofacitinib ulcerative colitis clinical programme." Journal of Crohn's and Colitis 14, Supplement_1 (January 2020): S566—S567. http://dx.doi.org/10.1093/ecco-jcc/jjz203.827.
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Abstract Background The Short Form-36 Health Survey version 2 (SF-36v2) is a generic health-related quality-of-life (HRQoL) instrument [1]. Tofacitinib is an oral, small molecule JAK inhibitor for the treatment of ulcerative colitis (UC). In these exploratory analyses the concordance between total and partial Mayo scores and SF-36v2 scores was evaluated in patients with UC in the Phase 3 tofacitinib 8-week OCTAVE Induction 1&2 (NCT01465763; NCT01458951) and 52-week OCTAVE Sustain (NCT01458574) studies. Methods A repeated measures regression model was used to evaluate the relationship between total and partial Mayo scores (as predictor) and SF-36v2 component and domain scores. A sensitivity analysis to assess the linearity assumption was performed using Mayo score as a categorical anchor (represented by integer values 0–12 [total] or 0–9 [partial]). Previous analyses identified clinically important differences (CIDs) in total and partial Mayo scores as changes of 3 points and 2.25 points, respectively [2]. Mean differences in SF-36v2 component and domain scores were compared with their recommended group-level CID thresholds [3]. Results Clinically meaningful differences of 3 points and 2.25 points in total and partial Mayo scores, respectively, were generally associated with clinically meaningful differences in SF-36v2 component and domain scores, with the exception of Role-Emotional with partial Mayo score in the pooled induction studies and with total Mayo score in the maintenance study. In the induction studies, a 3-point difference in total Mayo score was associated with a mean difference exceeding CIDs in both the SF-36v2 Physical Component Summary score (mean improvement 4.5; 95% confidence interval [CI] 4.2, 4.7) and Mental Component Summary score (mean improvement 5.0; 95% CI 4.6, 5.3). Results were closely aligned when Mayo score was used as a categorical or continuous anchor, supporting a linear relationship between Mayo score and SF-36v2 scores (Figure). Similar results were observed in the maintenance study, and when assessing the relationship of partial Mayo score with SF-36v2 scores. Conclusion Clinically meaningful decreases in disease activity, as measured by Mayo score, were associated with clinically meaningful benefits in HRQoL, as measured by SF-36v2 component and domain scores. These findings highlight the impact that disease activity has on HRQoL and may assist with articulating the treatment effect of tofacitinib on specific domains. References
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Bell, MHA, Timothy, Kathy Annunziata, MA, and John B. Leslie, MD, MBA. "Opioid-induced constipation negatively impacts pain management, productivity, and health-related quality of life: Findings from the National Health and Wellness Survey." Journal of Opioid Management 5, no. 3 (January 29, 2018): 137. http://dx.doi.org/10.5055/jom.2009.0014.
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Objective: To characterize the impact of opioidinduced constipation (OIC) on healthcare resource use, work productivity, and health-related quality of life (HRQOL) in patients receiving chronic opioid therapy.Design: Data were collected via Internet questionnaires during the international National Health and Wellness Survey (NHWS) 2004 from individuals aged ≥18 years who reported taking opioids for ≥6 months. Healthcare resource utilization, Work Productivity, and Activity Impairment, and Short-Form 8 (SF-8) questionnaire responses were compared between those who did or did not report OIC.Results: Data were available from 2,430 individuals receiving opioids, of whom 359 reported OIC. Participants with OIC reported significantly more physician visits (mean difference 3.84 visits; p < 0.05) and alternative care provider visits (mean difference 1.73 visits; p < 0.05) over the previous 6 months than those without OIC; however, no significant differences in emergency room visits or number of days of hospitalization were observed. Respondents with OIC also reported significantly greater time missed from work, impairment while working, overall work impairment, and activity impairment (p < 0.05 for all comparisons). HRQOL scores were significantly lower in the OIC group than those without OIC on both the physical and mental components of the SF-8 questionnaire (p < 0.05 for both comparisons).Conclusions: The survey results reflect a negative impact of OIC on individuals’ HRQOL and on society in terms of healthcare resource use and work productivity beyond that imposed by patients’ pain conditions. These findings indicate a need for effective treatment for opioid-induced constipation in patients receiving chronic opioid therapy.
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Poder, Thomas G., Liang Wang, and Nathalie Carrier. "EQ-5D-5L and SF-6Dv2 utility scores in people living with chronic low back pain: a survey from Quebec." BMJ Open 10, no. 9 (September 2020): e035722. http://dx.doi.org/10.1136/bmjopen-2019-035722.
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ObjectiveTo describe how chronic low back pain (CLBP) impacts on utility scores and which patients’ characteristics most affect these scores in the province of Quebec.SettingsProvince of Quebec, Canada.Participants569 adult patients with CLBP.Methods and outcomesAn online survey on low back pain was conducted between October 2018 and January 2019. The EuroQol Five Dimensions (EQ-5D-5L) and the Short Form Six Dimensions version 2 (SF-6Dv2) are two generic preference-based measures used to evaluate health-related quality of life (HRQoL) and provide quality-adjusted life-year utility values.ResultsThe number of subjects who agreed to participate was 610, but 41 were excluded because 8 had low back pain for less than 3 months and 33 did not start the survey. A total of 569 subjects were analysed, but only 410 completed the survey up to the EQ-5D-5L or SF-6Dv2 sections. Median (range) of EQ-5D-5L was 0.622 (−0.072 to 0.905), and mean (range) of SF-6Dv2 and EQ-Visual Analogue Scale was 0.561 (0.301–0.829) and 51.0 (0–100), respectively. In all multivariate models, health or life satisfaction increased the health utility score, while pain reduced it. Co-occurring health problems were present for a majority (68%) of participants, mainly fatigue/insomnia (57.4%), musculoskeletal disorder (56.2%) and mental disorder (44%).ConclusionThis study provided utility scores with EQ-5D-5L and SF-6Dv2 in patients with CLBP in Quebec, and results were similar to other studies conducted in different settings. These values were well below those reported in the Quebec general population and highlight the association between CLBP and HRQoL.
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Tabacco, Gaia, Yu-Kwang Donovan Tay, Natalie E. Cusano, John Williams, Beatriz Omeragic, Rukhana Majeed, Maximo Gomez Almonte, Mishaela R. Rubin, and John P. Bilezikian. "Quality of Life in Hypoparathyroidism Improves With rhPTH(1-84) Throughout 8 Years of Therapy." Journal of Clinical Endocrinology & Metabolism 104, no. 7 (February 18, 2019): 2748–56. http://dx.doi.org/10.1210/jc.2018-02430.
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Abstract Context Calcium and vitamin D treatment does not improve reduced quality of life (QOL) in hypoparathyroidism. Recombinant human (rh) PTH(1-84) therapy improves QOL metrics for up to 5 years. Data on QOL beyond this time point are not available. Objectives To evaluate the effects of 8 years of rhPTH(1-84) therapy on QOL and factors associated with long-term benefit. Design Prospective, open-label trial. Setting Referral center. Patients Twenty patients with hypoparathyoidism. Main Outcome Measures RAND 36-Item Short Form Health Survey (SF-36). Results rhPTH therapy led to substantial improvement in five of the eight SF-36 domains [vitality, social functioning (SF), mental health (MH), bodily pain (BP) and general health] and three of these domains (SF, MH, BP) were no longer lower than the reference population. The improvement in the mental component summary (MCS) score was sustained through 8 years, while the physical component summary (PCS) score improved through 6 years. A lower baseline QOL score was associated with greater improvement. A threshold value <238 (MCS) and <245 (PCS) predicted long-term improvement in 90% and 100% of the cohort, respectively. In patients whose calcium supplementation was reduced, MCS and PCS scores improved more than those whose supplementation did not decline to the same extent. Improvement in PCS was greater in patients whose calcitriol dosage was reduced and duration of disease was shorter. Conclusions rhPTH(1-84) improves long-term well-being in hypoparathyroidism. The improvements are most prominent in those with impaired SF-36 at baseline and those whose requirements for conventional therapy decreased substantially.
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Barranco-Ruiz, Yaira, Susana Paz-Viteri, and Emilio Villa-González. "Dance Fitness Classes Improve the Health-Related Quality of Life in Sedentary Women." International Journal of Environmental Research and Public Health 17, no. 11 (May 26, 2020): 3771. http://dx.doi.org/10.3390/ijerph17113771.
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Introduction: This study aims to analyze the effect of two dance-focused and choreographic fitness classes on Health-Related Quality of Life (HRQoL) in sedentary worker women. Methods: 65 sedentary middle-aged worker women (38 ± 7.3 years old) completed a 16-week intervention randomly assigned to: (1) dance fitness group based on Zumba Fitness classes (DF group, n = 25)], (2) dance fitness + functional strength training group (DFFT group, n = 20), and (3) control group (n = 20). HRQoL was assessed by the 36-Item Short-Form Health-Survey (SF-36), which evaluates 8 dimensions of health [General Health (GH), Physical Functioning (PF), Social Functioning (SF), Physical Role (PR), Emotional Role (ER), Bodily Pain (BP), Vitality (V), and Mental Health (MH)] scored from 0 (worst) to 100 (best health status). Results: The control group statistically differed from both exercise groups in PF and PR, and from the DF group in SF and MH showing a lower score. No statistical differences were observed between exercise groups post-intervention, except in V. DF group showed increases in GH, PF, SF, V, PR, and MH post-intervention. Conclusions: A 16-week dance fitness intervention based on Zumba Fitness classes generates notable improvements in a wide range of HRQoL dimensions in sedentary middle-aged worker women, especially in V, PR and MH dimensions.
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Patel, R., F. Boselli, I. Cairo, G. Barnett, M. Price, and H. C. Wulf. "Patients' perspectives on the burden of recurrent genital herpes." International Journal of STD & AIDS 12, no. 10 (October 1, 2001): 640–45. http://dx.doi.org/10.1258/0956462011923859.
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The purpose of this study was to quantify the impact of recurrent genital herpes (RGH) on health-related quality of life, healthcare resource and workplace productivity. This was a cross-sectional survey conducted in 5 countries (Australia, Denmark, Italy, The Netherlands and UK). Patients with a confirmed history of RGH completed the MOS 36-Item Short Form Health Survey (SF-36) and the Recurrent Genital Herpes Quality of Life questionnaire (RGHQoL). Questionnaires addressing frequency of access to healthcare services and workplace productivity were also completed and patients' medical history was obtained. Scores for 6 of the 8 domains of the SF-36 were significantly lower ( P<0.001) i.e. worse, compared with scores for the normal population. The RGHQoL score was significantly lower in patients experiencing more frequent or more severe recurrences. Forty-five per cent of patients estimated that their work effectiveness was reduced by between 25% and 50% due to genital herpes symptoms.
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Mukoyama, Nobuaki, Naoki Nishio, Hiroyuki Kimura, Shinichi Kishi, Tatsuya Tokura, Hiroki Kimura, Mariko Hiramatsu, et al. "Prospective Evaluation of Health-Related Quality of Life in Patients Undergoing Anterolateral Craniofacial Resection with Orbital Exenteration." Journal of Neurological Surgery Part B: Skull Base 81, no. 05 (July 24, 2019): 585–93. http://dx.doi.org/10.1055/s-0039-1694010.
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Objective This study was aimed to evaluate health-related quality of life in patients undergoing anterolateral craniofacial resection (AL-CFR) with orbital exenteration (OE) for malignant skull base tumors and to investigate the effects of early psychiatric intervention. Design Present study is a prospective, observational study. Setting The study took place at the hospital department. Participants Twenty-six consecutive patients were selected who underwent AL-CFR with OE at our hospital between 2005 and 2015. Main Outcome Measures Health-related quality of life was assessed preoperatively and 3, 6, 12, and 24 months after surgery using the Hospital Anxiety and Depression Scale (HADS) and medical outcomes study 8-items Short Form health survey (SF-8). In all cases, psychiatric intervention was organized by the consultation liaison psychiatry team preoperatively and postoperatively. Results Ten (38.0%) of the 26 patients died and 16 (62.0%) were alive and disease-free at the end of the study. The 3-year overall and disease-free survival rates were 64.9% and 53.3%, respectively. Twenty-one patients (80.8%) developed psychiatric complications after surgery and needed treatment with psychotropic medication. Before surgery, 28% of patients had HADS scores ≥8 for anxiety and 20% had scores ≥8 for depression. Seven of the eight items in the SF-8 were significantly lower than those for the general Japanese population. However, scores for all the SF-8 items gradually improved during postoperative follow-up, reaching approximately 50 points, which is the national standard value, at 2 years after surgery. Conclusions Craniofacial resection with OE was feasible and well tolerated in patients with malignant skull base tumors who received early psychiatric intervention to decrease the considerable psychological impact of this procedure.
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Lowe, Kimberly A., M. Robyn Andersen, Erin Sweet, Leanna Standish, Charles W. Drescher, and Barbara A. Goff. "The Effect of Regular Exercise and Yoga on Health-Related Quality of Life Among Ovarian Cancer Survivors." Journal of Evidence-Based Complementary & Alternative Medicine 17, no. 3 (June 17, 2012): 155–60. http://dx.doi.org/10.1177/2156587212448799.
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There is growing interest in understanding the influence of yoga on health outcomes and health-related quality of life among cancer survivors. This cross-sectional study evaluated the effects of participating in regular exercise alone or in conjunction with yoga on health-related quality of life among 219 ovarian cancer survivors using the SF-36 health survey. Multivariate regression was used to assess the association between the exercise/yoga categories on the 8 SF-36 scales. The results suggest that survivors who participated in both regular exercise and yoga had higher scores in physical functioning, fewer limitations with physical and emotional health, less pain, and more vitality than survivors who reported participating in regular exercise only. These results highlight the utility of exercise as a potential predictor of health-related quality of life in ovarian cancer survivors and support adding yoga to an exercise program.
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Cowee, Katlyn, and Janet E. Simon. "A History of Previous Severe Injury and Health-Related Quality of Life Among Former Collegiate Athletes." Journal of Athletic Training 54, no. 1 (January 1, 2019): 64–69. http://dx.doi.org/10.4085/1062-6050-377-17.
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ContextEmpirical evidence supports the idea that previous severe injuries in former collegiate athletes may adversely affect their ability to participate in daily activities later in life, which may then decrease their health-related quality of life (HRQOL).ObjectiveTo assess the influences of previous severe injuries on the HRQOL of former National Collegiate Athletic Association (NCAA) athletes.DesignCross-sectional study.SettingOnline survey.Patients or Other ParticipantsA total of 171 former NCAA collegiate athletes (69 men, 102 women; age = 29.7 ± 3.9 years, height = 171.5 ± 10.4 cm, mass = 76.4 ± 12.9 kg) participated. All individuals completed a demographics questionnaire and the Short Form-36 version 2 (SF-36v2) Health Survey via Qualtrics.Main Outcome Measure(s)The dependent variables were the physical composite and mental composite summary scores and the 8 subscales of the SF-36v2. The independent variable was the presence of previous severe injury (history of a severe injury or no history of a severe injury during collegiate athletics). Two multivariate analyses of variance were conducted. The first multivariate analysis of variance was conducted for the 8 SF-36v2 subscales and the second for the 2 summary scores.ResultsFor the summary scores and all 8 SF-36v2 subscales, the responses were worse for the 103 former collegiate athletes who sustained a previous severe injury compared with the 68 who did not sustain a severe injury. The largest difference between groups was for the physical composite score, with a mean difference of 15.8 points (1.5 standard deviations worse than the US population); the physical functioning subscale demonstrated a mean difference of 12.9 points (1.3 standard deviations worse than the US population).ConclusionsA majority of the athletes in our sample had experienced a severe injury. Based on these data, previous severe injuries had a negative influence on the HRQOL of former NCAA collegiate athletes.
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Buchanan, Robert J., and Chunfeng Huang. "The Need for Mental Health Care Among Informal Caregivers Assisting People with Multiple Sclerosis." International Journal of MS Care 15, no. 2 (June 1, 2013): 56–64. http://dx.doi.org/10.7224/1537-2073.2012-030.
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The objective of this study was to identify characteristics of informal caregivers and people with multiple sclerosis (MS) receiving assistance that are associated with the caregiver's perceived need for mental health care. Survey data were collected in interviews with 530 caregivers and analyzed using a logistic regression model. We found that older caregiver age significantly decreased the odds of caregivers' perceived need for mental health treatment. Better mental health domains of health-related quality of life among caregivers, as measured by the 8-item Short Form Health Status Survey (SF-8), also were associated with decreased odds of the need for mental health care. In contrast, the caregiver's feeling that providing assistance was emotionally draining or the belief that this assistance threatened the caregiver/care recipient relationship significantly increased the odds of caregivers' needing mental health treatment. Health professionals treating informal caregivers should be sensitive to the impact that providing assistance has on the emotions, relationships, and mental health needs of caregivers.
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FAURSCHOU, MIKKEL, LENE SIGAARD, JAKOB BUE BJORNER, and BO BASLUND. "Impaired Health-related Quality of Life in Patients Treated for Wegener’s Granulomatosis." Journal of Rheumatology 37, no. 10 (August 3, 2010): 2081–85. http://dx.doi.org/10.3899/jrheum.100167.
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Objective.To investigate whether patients with Wegener’s granulomatosis (WG) experience reduced health-related quality of life (HRQOL) after accomplishment of remission, and to study the influence of WG-associated organ damage on HRQOL.Methods.Sixty-eight patients with inactive WG and 680 randomly selected, age- and sex-matched controls of the Danish background population completed the Medical Outcomes Study Short-Form 36 (SF-36) survey for evaluation of HRQOL. Irreversible organ damage attributable to WG and/or its treatment was assessed using the Vasculitis Damage Index (VDI).Results.The median disease duration was 7.5 (range 1–26) years in the WG group, and the median total VDI score was 2.0 (range 0–7). Compared to controls, WG patients reported impaired HRQOL reflected by significantly lower SF-36 physical component summary scores (PCS) and mental component summary scores (MCS) (p < 0.001) and by significantly lower scores in 7 out of 8 SF-36 subscales (p ≤ 0.001). In the WG group, no statistically significant correlations were found between the different SF-36 scores and the total VDI score, number of organ systems affected by damage, disease duration, or number of WG relapses. Patients with organ failure or other major forms of damage did not report significantly lower HRQOL than less severely affected patients.Conclusion.WG patients experience significantly reduced HRQOL even in phases with no apparent vasculitis disease activity. Our data indicate that the level of HRQOL does not correlate well with the extent of vasculitis-associated organ damage in WG.
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BRUGHA, T. S., F. NIENHUIS, D. BAGCHI, J. SMITH, and H. MELTZER. "The survey form of SCAN: the feasibility of using experienced lay survey interviewers to administer a semi-structured systematic clinical assessment of psychotic and non-psychotic disorders." Psychological Medicine 29, no. 3 (May 1999): 703–11. http://dx.doi.org/10.1017/s003329179900834x.
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Background. The success of large scale surveys depends on well designed questionnaires and the skills of lay interviewers. Discrepancies in prevalence rates between epidemiological surveys and poor agreement between survey interviewer and clinician diagnostic interviews are giving rise to increasing concern among researchers, public health planners and policy developers. New approaches to information collection are called for. The feasibility of training experienced survey interviewers in semi-structured, clinical, diagnostic interviewing has never been investigated systematically across the range of neurotic and psychotic disorders.Methods. Eight experienced survey interviewers from the Office for National Statistics (ONS) were selected and underwent extended training in a Survey Form of SCAN (SCAN-SF). Sixty-four adults, including a majority of psychiatric in-patients were assessed by ONS interviewers and re-interviewed within a week by SCAN-trained clinicians. Feedback was sought from interviewers and trainers.Results. Trainers found lay interviewers coped at least as well with psychotic as with neurotic symptoms. Concordance for any disorder was 0·74 (95% CI: 0·57 to 0·91); for any specific psychotic disorder 0·63 (0·40 to 0·86); for any specific neurotic disorder 0·63 (0·43 to 0·83). Sensitivity ranged from 0·6 to 0·9 and specificity from 0·8 to 0·9. There was no evidence of rater bias.Conclusions. These preliminary findings are very promising. However, before the SCAN-SF, administered by carefully trained lay interviewers, can be recommended in large scale surveys, further evaluations of its feasibility and reliability in the general population are needed.
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Cancelliero-Gaiad, Karina Maria, Daniela Ike, Liliana Soave, Evelim Leal de Freitas Dantas Gomes, Fernanda Dultra Dias, and Dirceu Costa. "Correlation between functional capacity and health-related quality of life in COPD: a case series." Fisioterapia em Movimento 27, no. 4 (December 2014): 505–14. http://dx.doi.org/10.1590/0103-5150.027.004.ao02.
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Objective To correlate functional capacity test scores from chronic obstructive pulmonary disease (COPD) subjects with their functional state as assessed by health-related quality of life questionnaires (one respiratory disease-specific [SGRQ] and one generic [SF-36] questionnaire). Materials and methods Study of a case series of 8 COPD patients. The following tests were performed: 1) Six-minute walk test (6-MWT); 2) Shuttle walking test (SWT); 3) Six-minute step test (6-MST); 4) Two-minute sit-to-stand test (STST); and 5) Pegboard and ring test (PBRT). Besides these tests, two health-related quality of life questionnaires were administered: The St George's Respiratory Questionnaire (SGRQ) and the Short Form 36 (SF-36) health survey questionnaire. The statistical analysis was carried out by using the Shapiro-Wilk normality test, while correlations were assessed using Pearson's (parametric data) or Spearman's (non-parametric data) rank tests, with p < 0.05. Results The 6-MWT showed strong correlation with the SF-36 scales of physical functioning, general health, vitality, social functioning and mental health. Conversely, the other functional capacity tests showed no correlation with this questionnaire. The SGRQ showed no correlation with any of the tests. Conclusions The 6-MWT may be a good test to reflect the health-related quality of life of COPD subjects.
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Strand, V., P. Patel, N. Chen, and E. Lesser. "AB0835 THE IMPACT OF ADALIMUMAB VS PLACEBO ON PATIENT-REPORTED OUTCOMES AND UTILITY MEASURES AMONG PATIENTS WITH MODERATELY TO SEVERELY ACTIVE PSORIATIC ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1722–23. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1254.
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Background:Physical function and health-related quality of life(HRQoL) are negatively impacted in patients(pts) with PsA. Treatment with conventional and biological (b) DMARDs improved patient-reported outcomes(PROs).Objectives:To assess impact of adalimumab(ADA) vs placebo(PBO) on PROs following 12-week (wk) treatment.Methods:Pts(n=315) with moderately to severely active PsA and bDMARD naive were randomized to ADA 40mg or PBO every other wk. We assessed PROs at baseline(BL) and wk 12 using the 36-item Short-Form(SF-36) Health Survey physical(PCS) and mental component summary(MCS) scores, 8 domain scores ranging from 0(worst) to 100(best), and SF-6D utility measure derived from all 8 SF-36 domains with scores ranging from 0.296(worst) to 1.00(full health) and minimally important difference(MID) of 0.041. Patient Global Assessment of disease activity(PtGA) and pain(both utilizing 100 mm visual analog scale[VAS]) and HAQ disability index(DI) were assessed. Mean changes from BL, percentages of pts with improvements ≥minimum clinically important differences(MCID), and scores ≥US age-and gender-matched normative values(A/G norms) were analyzed, based on as observed data.Pvalues were assessed by analysis of variance model for continuous variables andCochran–Mantel–Haenszeltest for binary outcomes, adjusting by baseline MTX use and extent of psoriasis. Numbers needed to treat(NNTs) are reported using proportions of pts reporting improvements ≥MCID in SF-36, PtGA, pain, and HAQ-DI.Results:BL PRO scores were similar between ADA(n=151) and PBO(n=162;Table 1). Improvements from BL at wk 12 with ADA vs PBO were significant in PtGA, pain, HAQ-DI, and SF-36 PCS(change: 9.3 vs 1.4;P<0.001) but not in SF-36 MCS(1.6 vs 1.2;Table 1). Six of 8 SF-36 domains significantly improved from BL to wk 12 with ADA vs PBO(allP≤0.05;Table 1andFigure 1). SF-6D improvements exceeded MID with ADA(change: 0.071) vs PBO(0.018). Proportions of pts reporting improvements ≥MCID at wk 12 were significantly greater with ADA vs PBO in all PROs, except SF-36 role emotional and mental health domains, with corresponding NNTs ≤6.4(Figure 2). Proportions of pts who reported scores ≥A/G norms in HAQ-DI, SF-36 PCS, and 6 of 8 SF-36 domains were significantly greater with ADA vs PBO(Figure 2).Table 1.Mean Disease Characteristics and SF-36 Domain Scores by Treatment Group at Baseline and Wk 12 Compared With Age-and Gender-Matched Normative ValuesADA 40 mg eowPBOA/G normsBaselineWeek 12[change from baseline to week 12]BaselineWeek 12[change from baseline to week 12]SF-36 PCS33.242.5[9.3**]33.334.7[1.4]≥50SF-36 MCS48.149.8[1.6]46.648.4[1.2]≥50SF-6D0.6530.724[0.071]0.6410.659[0.018]—PtGA47.125.9[–21.7**]48.147.5[0.2]—Pt pain51.126.8[–24.1**]48.849.1[1.3]—HAQ-DI1.00.6[–0.4**]1.00.9[–0.1]≤0.25Baseline(vs A/G norms)Week 12(vs A/G norms)Baseline(vs A/G norms)Week 12(vs A/G norms)Physical Functioning50.8(−31.5)65.9***(−16.4)48.2(−34.1)52.0(−30.3)82.3Role Physical37.1(−45.9)65.9***(−17.1)32.6(−50.4)40.6(−42.4)83.0Bodily Pain41.3(−31.6)61.0***(−11.9)40.2(−32.7)43.7(−29.2)72.9General Health49.5(−20.8)62.1***(−8.2)52.1(−18.2)53.0(−17.3)70.3Vitality41.4(−17.8)55.1***(−4.1)41.6(−17.6)45.0(−14.2)59.2Social Functioning66.3(−19.0)77.8†(−7.5)61.7(−23.6)66.7(−18.6)85.3Role Emotional65.1(−23.4)70.4(−18.1)59.1(−29.4)66.0(−22.5)88.5Mental Health67.6(−8.5)72.9(−3.2)64.9(−11.2)67.3(−8.8)76.1ADA, adalimumab; A/G norm, age-and gender-matched normative value; eow, every other week; DI, disability index; MCS, mental component summary; MID, minimally important difference; PBO, placebo; PCS, physical component summary; PtGA, Patient Global Assessment of disease activity; SF-36, 36-item Short-Form Health Survey; SF-6D, Short-Form 6D.SF-6D MID=0.041.Statistical analysis ADA vs PBO:†P<0.05; *P<0.01; **P<0.001; ***P<0.0001.Conclusion:Statistically significant and clinically meaningful improvements and scores ≥A/G norms(higher definition of response) at week 12 were reported with ADA vs PBO in pts with moderately to severely active PsA.Disclosure of Interests:Vibeke Strand Consultant of: AbbVie, Amgen, Biogen, Celltrion, Consortium of Rheumatology Researchers of North America, Crescendo Bioscience, Eli Lilly, Genentech/Roche, GlaxoSmithKline, Hospira, Janssen, Merck, Novartis, Pfizer, Regeneron Pharmaceuticals, Inc., Sanofi, UCB, Pankaj Patel Shareholder of: AbbVie, Employee of: AbbVie, Naijun Chen Shareholder of: AbbVie Inc, Employee of: AbbVie Inc, Elizabeth Lesser Shareholder of: AbbVie Inc, Employee of: AbbVie Inc
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Vadivelu, Sangeta, Zheng Feei Ma, Ean Wah Ong, Norhaliza Hassan, Nik Fariza Husna Nik Hassan, Syed Hassan Syed Abdul Aziz, Yee Cheng Kueh, and Yeong Yeh Lee. "Clinical Validity and Reliability of the Malay Language Translations of Gastroesophageal Reflux Disease Questionnaire and Quality of Life in Reflux and Dyspepsia Questionnaire in a Primary Care Setting." Digestive Diseases 37, no. 2 (November 1, 2018): 100–107. http://dx.doi.org/10.1159/000494386.
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Background: Gastroesophageal Reflux Disease Questionnaire (GERDQ) and Quality of Life in Reflux and Dyspepsia Questionnaire (QOLRAD) are reliable tools for evaluation of GERD. Aim: We aimed to test validity and reliability of Malay language translations of GERDQ and QOLRAD in a primary care setting. Methods: The questionnaires were first translated into the Malay language (GERDQ-M and QOLRAD-M). Patients from primary care clinics with suspected GERD were recruited to complete GERDQ-M, QOLRAD-M, and Malay-translated 36-item short-form health survey (SF-36 or SF-36-M), and underwent endoscopy and 24-h pH-impedance test. Results: A total of 104 (mean age 47.1 years, women 51.9%) participants were enrolled. The sensitivity and specificity for GERDQ-M cut-off score ≥8 were 90.2 and 77.4%, respectively. Based on this cut-off score, 54.7% had a high probability of GERD diagnosis. GERD-M score ≥8 vs. < 8 was associated with erosive esophagitis (p < 0.001), hiatus hernia (p = 0.03), greater DeMeester score (p = 0.001), and Zerbib scores for acid refluxes (p < 0.001) but not non-acid refluxes (p = 0.1). Mean total scores of QOLRAD-M and SF-36-M were correlated (r = 0.74, p < 0.001). GERDQ-M ≥8, erosive esophagitis, and DeMeester ≥14.72 were associated with impaired QOLRAD-M in all domains (all p < 0.02) but this was not seen with SF-36. Conclusions: GERDQ-M and QOLRAD-M are valid and reliable tools applicable in a primary care setting.
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Jang, Sun Mi, Ki Uk Kim, Hae Jung Na, Seung Eun Song, Sang Hee Lee, Haejung Lee, Yun Seong Kim, Min Ki Lee, and Hye-Kyung Park. "Depression is a major determinant of both disease-specific and generic health-related quality of life in people with severe COPD." Chronic Respiratory Disease 16 (May 9, 2018): 147997231877542. http://dx.doi.org/10.1177/1479972318775422.
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The quality of life of patients with chronic obstructive pulmonary disease (COPD) decreases significantly as the disease progresses; those with severe COPD are affected most. This article investigates predictors of the disease-specific and generic health-related quality of life (HRQL) in patients with severe COPD. This multicentre prospective cross-sectional study enrolled 80 patients with severe COPD. At enrolment, all patients completed a disease-specific instrument, the St George’s Respiratory Questionnaire (SGRQ), and a generic instrument, the Short Form 36 Health Survey Questionnaire (SF-36). The data were analyzed by Pearson’s correlation and multiple linear regression. The mean age of the patients was 66 ± 8 years; 93% were males. The SGRQ and SF-36 scores were not influenced by age or sex. Depression, dyspnea, the number of exacerbations, and exercise capacity significantly predicted the total SGRQ score ( p < 0.05). Depression was the strongest determinant of the total SGRQ score. The SF-36 physical component summary scores were related to depression, dyspnea, and the number of exacerbations ( p < 0.05). In comparison, the SF-36 mental component summary scores were related to depression and anxiety ( p < 0.05). Depression is a significant determinant of both the disease-specific and generic HRQL in patients with severe COPD. Screening and early intervention for depression in patients with severe COPD could improve the HRQL.
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Clayborne, Zahra M., and Ian Colman. "Associations between Depression and Health Behaviour Change: Findings from 8 Cycles of the Canadian Community Health Survey." Canadian Journal of Psychiatry 64, no. 1 (May 7, 2018): 30–38. http://dx.doi.org/10.1177/0706743718772523.
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Objectives: The primary objective of this study was to examine associations between depression and several measures of health behaviour change across 8 cycles of a population-based, cross-sectional survey of Canadians. The secondary objective of this study was to describe the prevalence of the types of health behaviour changes undergone/sought and types of barriers to change reported, comparing those with and without depression. Methods: The sample comprised 65,801 respondents to the Canadian Community Health Survey between 2007 and 2014. Past-year depression was assessed via structured interview (CIDI-SF). Measures of health behaviour change included recent changes made, desire to make changes, and barriers towards making changes. Analyses involved logistic regression, with estimates across cycles pooled using fixed-effects meta-analyses. Pooled prevalences of types of health behaviour changes undergone/sought and types of barriers to change experienced were reported, and associations with depression were examined. Results: Depression was associated with higher odds of reporting a recent health behaviour change (pooled odds ratio [OR] = 1.39; 95% confidence interval [CI], 1.30 to 1.48), desire to make health behaviour changes (pooled OR = 1.61; 95% CI, 1.49 to 1.74), and barriers towards change (pooled OR = 1.54; 95% CI, 1.44 to 1.65). The most common change undergone and sought was increased exercise; the most common barrier reported was a lack of willpower. Conclusions: Individuals dealing with depression are more likely to report recent health behaviour changes and the desire to make changes but are also more likely to report barriers towards change.
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Contou, Damien, Florence Canoui-Poitrine, Rémi Coudroy, Sébastien Préau, Martin Cour, François Barbier, Nicolas Terzi, et al. "Long-term Quality of Life in Adult Patients Surviving Purpura Fulminans: An Exposed-Unexposed Multicenter Cohort Study." Clinical Infectious Diseases 69, no. 2 (October 16, 2018): 332–40. http://dx.doi.org/10.1093/cid/ciy901.
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Abstract Background Long-term health-related quality of life (HR-QOL) of patients surviving the acute phase of purpura fulminans (PF) has not been evaluated. Methods This was a French multicenter exposed-unexposed cohort study enrolling patients admitted in 55 intensive care units (ICUs) for PF from 2010 to 2016. Adult patients surviving the acute phase of PF (exposed group) were matched 1:1 for age, sex, and Simplified Acute Physiology Score II with septic shock survivors (unexposed group). HR-QOL was assessed during a phone interview using the 36-Item Short-Form Health Survey (SF-36) questionnaire, the Hospital Anxiety and Depression (HAD) scale, the Impact of Event Scale–Revised (IES-R), and the activity of daily living (ADL) and instrumental ADL (IADL) scales. The primary outcome measure was the physical component summary (PCS) of the SF-36 questionnaire. Results Thirty-seven survivors of PF and 37 of septic shock were phone-interviewed at 55 (interquartile range [IQR], 35–83) months and 44 (IQR, 35–72) months, respectively, of ICU discharge (P = .23). The PCS of the SF-36 was not significantly different between exposed and unexposed patients (median, 47 [IQR, 36–53] vs 54 [IQR, 36–57]; P = .18). There was also no significant difference between groups regarding the mental component summary of the SF-36, and the HAD, IES-R, ADL and IADL scales. Among the 37 exposed patients, those who required limb amputation (n = 12/37 [32%]) exhibited lower PCS (34 [IQR, 24–38] vs 52 [IQR, 42–56]; P = .001) and IADL scores (7 [IQR, 4–8] vs 8 [IQR, 7–8]; P = .021) compared with nonamputated patients. Conclusions Long-term HR-QOL does not differ between patients surviving PF and those surviving septic shock unrelated to PF. Amputated patients have an impaired physical HR-QOL but a preserved mental health. Clinical Trials Registration NCT03216577.
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Silva, Amanda Aparecida, José Maria Pacheco de Souza, Flávio Notarnicola da Silva Borges, and Frida Marina Fischer. "Health-related quality of life and working conditions among nursing providers." Revista de Saúde Pública 44, no. 4 (August 2010): 718–25. http://dx.doi.org/10.1590/s0034-89102010000400016.
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OBJECTIVE: To evaluate working conditions associated with health-related quality of life (HRQL) among nursing providers. METHODS: Cross-sectional study conducted in a university hospital in the city of São Paulo, Southeastern Brazil, during 2004-2005. The study sample comprised 696 registered nurses, nurse technicians and nurse assistants, predominantly females (87.8%), who worked day and/or night shifts. Data on sociodemographic information, working and living conditions, lifestyles, and health symptoms were collected using self-administered questionnaires. The following questionnaires were also used: Job Stress Scale, Effort-Reward Imbalance (ERI) and Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). Ordinal logistic regression analysis using proportional odds model was performed to evaluate each dimension of the SF-36. RESULTS: Around 22% of the sample was found to be have high strain and 8% showed an effort-reward imbalance at work. The dimensions with the lowest mean scores in the SF-36 were vitality, bodily pain and mental health. High-strain job, effort-reward imbalance (ERI>1.01), and being a registered nurse were independently associated with low scores on the role emotional dimension. Those dimensions associated to mental health were the ones most affected by psychosocial factors at work. CONCLUSIONS: Effort-reward imbalance was more associated with health than high-strain (high demand and low control). The study results suggest that the joint analysis of psychosocial factors at work such as effort-reward imbalance and demand-control can provide more insight to the discussion of professional roles, working conditions and HRQL of nursing providers.
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Yarlas, Aaron, Mary Kaye Willian, and Arpita Nag. "The impact of clinical symptoms and endoscopic and histologic disease activity on health-related quality of life in patients with ulcerative colitis following treatment with multimatrix mesalazine." Quality of Life Research 30, no. 7 (March 2, 2021): 1925–38. http://dx.doi.org/10.1007/s11136-021-02787-4.
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Abstract Purpose Studies of patients with ulcerative colitis (UC) report that reduced clinical symptoms and endoscopic activity predict better health-related quality of life (HRQoL). However, no study has examined the joint and unique associations of clinical and endoscopic activity with HRQoL, nor of histologic inflammation and HRQoL. These post hoc analyses evaluated whether reduced clinical, endoscopic, and histologic disease activity were uniquely associated with improved HRQoL for adults with active mild-to-moderate UC receiving once-daily 4.8 g/day multimatrix mesalazine for 8 weeks. Methods Assessments at baseline and week 8 (i.e., treatment completion) included clinical and endoscopic activity (modified UC-Disease Activity Index), histology (Geboes scoring), and HRQoL (Short Inflammatory Bowel Disease Questionnaire [SIBDQ]; SF-12v2® Health Survey [SF-12v2]). Associations among each type of disease activity and HRQoL were examined by correlations and by mean changes in SIBDQ and SF-12v2 scores between disease activity subgroups (e.g., achievement of clinical remission; mucosal healing). Regression models estimated unique variance in HRQoL accounted by each type of disease activity. Results Within the analysis sample (n = 717), patients with reduced clinical and endoscopic activity had significantly larger improvements in all HRQoL domains (p < 0.001), as did patients in both endoscopic and clinical remission compared to patients in endoscopic remission only (p < 0.05). Patients with histologic activity post-treatment scored significantly worse on all HRQoL domains than patients with no activity (p < 0.05). Correlations and regression models found that decreases in clinical and endoscopic activity were associated with improvements in HRQoL domain scores. Conclusions Clinical symptoms and mucosal health have separable, distinct impacts on UC patients’ HRQoL.
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Ogura, Yoji, Yoshio Shinozaki, Yoshiomi Kobayashi, Takahiro Kitagawa, Yoshiro Yonezawa, Yohei Takahashi, Kodai Yoshida, Akimasa Yasuda, and Jun Ogawa. "Impact of sagittal spinopelvic alignment on clinical outcomes and health-related quality of life after decompression surgery without fusion for lumbar spinal stenosis." Journal of Neurosurgery: Spine 30, no. 4 (April 2019): 470–75. http://dx.doi.org/10.3171/2018.10.spine181094.
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OBJECTIVEPatients with lumbar spinal stenosis (LSS) tend to bend forward to relieve neurological symptoms. They therefore have a positive sagittal vertical axis (SVA). The importance of the SVA value is well known in the field of adult spinal deformity; however, little is known about its impact on LSS. The authors sought to investigate the impact of sagittal spinopelvic alignment on clinical outcome and health-related quality of life (HRQOL) after decompression surgery for LSS.METHODSThe authors retrospectively reviewed 83 patients who underwent lumbar decompression without fusion between January 2014 and September 2015 with a minimum follow-up of 2 years. Standing whole-spine radiographs were examined preoperatively and at final follow-up. Based on the SVA, patients were allocated to a sagittal balance group (group B; SVA < 50 mm) or a sagittal imbalance group (group I; SVA ≥ 50 mm). The authors compared the groups using Japanese Orthopaedic Association (JOA), Zurich Claudication Questionnaire (ZCQ), Roland-Morris Disability Questionnaire (RMDQ), and the 8-item Short Form Health Survey (SF-8) scores.RESULTSPreoperative groups B (group pre-B) and I (group pre-I) included 58 and 25 patients, respectively. Preoperative sagittal malalignment had negative effects on the JOA score recovery rate, postoperative ZCQ physical function domain score, and numeric rating scale (NRS) score of postoperative low-back pain (LBP), but no significant effects were observed for RMDQ and SF-8 domain scores. Postoperatively, groups B (group post-B) and I (group post-I) included 60 and 23 patients, respectively. Group post-I had a significantly worse JOA score recovery rate, postoperative symptom severity domain score in the ZCQ, and NRS score for postoperative LBP. Similarly, the postoperative RMDQ score and the Physical Component Summary score of the SF-8 were significantly worse in group post-I.CONCLUSIONSPositive SVA had significantly negative effects on clinical outcome and HRQOL in LSS patients after lumbar decompression surgery.
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Diaz, Roberto Jose, Nicole Maggacis, Shudong Zhang, and Michael D. Cusimano. "Determinants of quality of life in patients with skull base chordoma." Journal of Neurosurgery 120, no. 2 (February 2014): 528–37. http://dx.doi.org/10.3171/2013.9.jns13671.
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Object Skull base chordomas can be managed by surgical intervention and adjuvant radiotherapy. As survival for this disease increases, identification of determinants of quality of life becomes an important focus for guiding comprehensive patient care. In this study the authors sought to measure functional outcome and quality of life in patients with skull base chordomas and to identify determinants of quality of life in these patients. Methods The authors carried out an internet-based cross-sectional survey, collecting detailed data for 83 individual patients. Demographic and clinical variables were evaluated. Functional outcomes were determined by Karnofsky Performance Scale (KPS) and Glasgow Outcome Scale Extended (GOSE), quality of life was measured using the 36-Item Short Form Health Survey (SF-36), and depression was assessed using Patient Health Questions–9 (PHQ-9) instrument. Caregiver burden was assessed using the Zarit Burden Interview (ZBI). Univariate and multivariate analysis was performed to identify determinants of the physical and mental components of the SF-36. Results Patients with skull base chordomas who have undergone surgery and/or radiation treatment had a median KPS score of 90 (range 10–100, IQR 10) and a median GOSE score of 8 (range 2–8, IQR 3). The mean SF-36 Physical Component Summary score (± SD) was 43.6 ± 11.8, the mean Mental Component Summary score was 44.2 ±12.6, and both were significantly lower than norms for the general US population (p < 0.001). The median PHQ-9 score was 5 (range 0–27, IQR 8). A PHQ-9 score of 10 or greater, indicating moderate to severe depression, was observed in 29% of patients. The median ZBI score was 12 (range 0–27, IQR 11), indicating a low burden. Neurological deficit, use of pain medication, and requirement for corticosteroids were found to be associated with worse SF-36 Physical Component Summary score, while higher levels of depression (higher PHQ-9 score) correlated with worse SF-36 Mental Component Summary score. Conclusions Patients with skull base chordomas have a lower quality of life than the general US population. The most significant determinants of quality of life in the posttreatment phase in this patient population were neurological deficits (sensory deficit and bowel/bladder dysfunction), pain medication use, corticosteroid use, and levels of depression as scored by PHQ-9.
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Vologdina, I. "Safety, effect anti tolerance of metoprolol in the treatment of elderly and old patients of cardiological profile." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 12, no. 1 (February 28, 2006): 52–55. http://dx.doi.org/10.18705/1607-419x-2006-12-1-52-55.
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76 elderly patients with cardiac heart disease (CHD) (31 male and 45 female) were included in the study. Mean age was 81.6 ± 3.4 (from 76 to 89) years. All investigated patients had stable angina pectoris (I-III class). The duration of disease was 8-15 years. The patients were hypertensive (mean arterial pressure 164.5 ± 5.8 / 100 ± 4.3 mm Hg) and had clinical symptoms of heart failure (II class by NYHA). The mental status was evaluated by variety specific tests. The quality of life was assessed by using questionnaire scale SF-36 Health Stains Survey. All subjects were treated by nitrates. ACE-inhibitors and diuretics. Patienis were divided into 2 groups, clinical data and demographies signs of witch, were comparable. 29 patients (1 group) received Metocard 25-100 mg per day. 27 patients were included in control group. Patients of 1 group demonstrated more pronounced increase of distance in test with 6-minutes walking. The depression level after treatment period was significantly reduced in patients of 1 group compare with control group and it's precede level (Camilton scale). Evaluation of quality of life following treatment period shewed statistically significant improvement of number indexes of scale SF-36 Health Status Survey.
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Hagberg, Kerstin, Rickard Brånemark, Björn Gunterberg, and Björn Rydevik. "Osseointegrated trans-femoral amputation prostheses: Prospective results of general and condition-specific quality of life in 18 patients at 2-year follow-up." Prosthetics and Orthotics International 32, no. 1 (January 1, 2008): 29–41. http://dx.doi.org/10.1080/03093640701553922.
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This is the first report on prospective outcome for individuals treated with bone-anchored trans-femoral amputation prostheses (OI-prostheses) using the method of osseointegration. The aim was to analyze general and condition-specific health related quality of life (HRQL) at 2-year follow-up as compared to the preoperative situation. The study population consists of the first 18 consecutively treated patients (8 male/10 female, mean age 45 years) in a clinical investigation with amputations mainly caused by trauma and tumour. At inclusion the mean time since the amputation was 15 years (10 months – 33 years). Two self-report questionnaires were answered preoperatively and at follow-up: the SF-36 Health Survey (SF-36) and the Questionnaire for persons with a Transfemoral Amputation (Q-TFA). At follow-up 17/18 patients used the OI-prosthesis; one did not due to pain and loosening of the implant. Four of the scales of the SF-36 (Physical Functioning, Role Functioning Physical, Bodily Pain and Physical Component Score) and all four scores of Q-TFA (Prosthetic Use, Prosthetic Mobility, Problems and Global Health) were statistically significantly improved at follow-up showing superior general physical HRQL, increased prosthetic use, better prosthetic mobility, fewer problems and a better global amputation situation. Thus, osseointegrated prostheses represent a promising development in the rehabilitation of individuals with transfemoral amputation and increase their quality of life.
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Sudevan, Remya, Manu Raj, Vasudevan Damodaran, Rajesh Thachathodiyl, Vijayakumar Maniyal, Jabir Abdullakutty, Paul Thomas, Vijo George, and Conrad Kabali. "Health-Related Quality of Life of Coronary Artery Disease Patients under Secondary Prevention: A Cross-Sectional Survey from South India." Heart Surgery Forum 24, no. 1 (February 15, 2021): E121—E129. http://dx.doi.org/10.1532/hsf.3261.
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Background: Health-related quality of life (HRQOL) is emerging as an important outcome among patients with documented coronary artery disease (CAD). The primary objective of this study was to report the HRQOL of CAD patients under secondary prevention-related treatment and follow-up using the 36-Item Short Form (SF-36) tool. Methods: This was an analytical cross-sectional survey done in a hospital/clinic setting. We recruited CAD patients 30 to 80 years old with 1 to 6 years of follow-up. Patients self-reported HRQOL using SF-36. Results: We recruited 1206 patients, among whom 879 (72.9%) were male. The mean age of patients was 61.3 (9.6) years. Mean (± standard deviation) scores for physical functioning, role limitations due to physical health, pain, and general health were 66.48 ± 29.41, 78.96 ± 28.01, 80.96 ± 21.15, and 51.49 ± 20.19, respectively. The scores for role limitations due to emotional problems, energy/fatigue, emotional well-being, and social functioning were 76.62 ± 28.0, 66.18 ± 23.92, 76.91 ± 20.47, and 74.49 ± 23.55. In subgroup analysis, age, sex, type of CAD, and treatment showed no significant association with any of the 8 domains of QOL. In addition, hypertension and diabetes showed no significant association with the individual domains of HRQOL. Conclusion: Patients with coronary artery disease under secondary prevention-related treatment have suboptimal HRQOL under both physical and mental domains. The role of demographic factors, comorbidities, disease subtypes, and treatment options in modifying HRQOL among patients with CAD appears to be minimal.
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Maunsell, Elizabeth, Paul E. Goss, Rowan T. Chlebowski, James N. Ingle, José E. Alés-Martínez, Gloria E. Sarto, Carol J. Fabian, et al. "Quality of Life in MAP.3 (Mammary Prevention 3): A Randomized, Placebo-Controlled Trial Evaluating Exemestane for Prevention of Breast Cancer." Journal of Clinical Oncology 32, no. 14 (May 10, 2014): 1427–36. http://dx.doi.org/10.1200/jco.2013.51.2483.
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Purpose Exemestane, a steroidal aromatase inhibitor, reduced invasive breast cancer incidence by 65% among 4,560 postmenopausal women randomly assigned to exemestane (25 mg per day) compared with placebo in the National Cancer Institute of Canada (NCIC) Clinical Trials Group MAP.3 (Mammary Prevention 3) trial, but effects on quality of life (QOL) were not fully described. Patients and Methods Menopause-specific and health-related QOL were assessed by using the four Menopause-Specific Quality of Life Questionnaire (MENQOL) domains and the eight Medical Outcomes Study Short Form Health Survey (SF-36) scales at baseline, 6 months, and yearly thereafter. MENQOL questionnaire completion was high (88% to 98%) in both groups at each follow-up visit. Change scores for each MENQOL and SF-36 scale, calculated at each assessment time relative to baseline, were compared by using the Wilcoxon rank-sum test. Clinically important worsened QOL was defined as a MENQOL change score increase of more than 0.5 (of 8) points and an SF-36 change score decrease of more than 5 (of 100) points from baseline. Results Exemestane had small negative effects on women's self-reported vasomotor symptoms, sexual symptoms, and pain, which occurred mainly in the first 6 months to 2 years after random assignment. However, these changes represented only a small excess number of women being given exemestane with clinically important worsening of QOL at one time or another; specifically, 8% more in the vasomotor domain and 4% more each in the sexual domain and for pain. No other between-group differences were observed. Overall, slightly more women in the exemestane arm (32%) than in the placebo arm (28%) discontinued assigned treatment. Conclusion Exemestane given for prevention has limited negative impact on menopause-specific and health-related QOL in healthy postmenopausal women at risk for breast cancer.
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Valovich McLeod, Tamara C., R. Curtis Bay, John T. Parsons, Eric L. Sauers, and Alison R. Snyder. "Recent Injury and Health-Related Quality of Life in Adolescent Athletes." Journal of Athletic Training 44, no. 6 (November 1, 2009): 603–10. http://dx.doi.org/10.4085/1062-6050-44.6.603.
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Abstract Context: Health-related quality of life (HRQOL) is a global concept that takes into account the physical, psychological, and social domains of health. Determining the extent to which injury affects HRQOL is an important aspect of rehabilitation practice, enabling comparisons of clinical outcomes across different conditions in diverse patient groups. Objective: To examine the extent to which a self-reported recent injury affected HRQOL in adolescent athletes using 2 generic patient self-report scales. Design: Cross-sectional study. Setting: High school classrooms and athletic training facilities. Patients or Other Participants: A convenience sample of uninjured (n = 160) and injured (n = 45) adolescent athletes. Intervention(s): The independent variable was injury status: uninjured versus injured. All participants completed a self-administered brief health status questionnaire and the Short Form–36 Health Survey Questionnaire (SF-36) and Pediatric Outcomes Data Collection Instrument (PODCI) in a counterbalanced manner. Main Outcome Measure(s): Dependent variables included 8 subscale and 2 composite scores of the SF-36 and 5 subscale scores and 1 global score of the PODCI. Group differences were assessed with the Mann-Whitney U test (P ≤ .05) and reported as median and interquartile range. Results: On the SF-36, the injured group demonstrated lower scores (P < .008) for physical functioning, limitations due to physical health problems, bodily pain, social functioning, and the physical composite. On the PODCI, the injured group reported lower scores (P < .01) on the pain and comfort subscale and the global score. Conclusions: Adolescent athletes with self-reported injuries demonstrated lower HRQOL than their uninjured peers. As expected, recent injury affected physical functioning and pain. Social functioning (on the SF-36) and global HRQOL (on the PODCI) also decreased, suggesting that injuries affected areas beyond the expected physical component of health. Clinicians need to recognize the full spectrum of negative influences that injuries may have on HRQOL in adolescent athletes.
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Kim, Jeong Ho, Monica Zigman, Jack T. Dennerlein, and Peter W. Johnson. "Cross-sectional Analysis of Whole Body Vibration Exposures and Health Status among Long-haul Truck Drivers." Proceedings of the Human Factors and Ergonomics Society Annual Meeting 60, no. 1 (September 2016): 928–32. http://dx.doi.org/10.1177/1541931213601213.
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Exposure to whole body vibration (WBV) is known to be associated with various adverse health outcomes among professional truck drivers. As a part of a randomized controlled trial, this study evaluated WBV exposures and various health outcomes from 96 professional truck drivers. The WBV was measured and analyzed per International Standards Organization (ISO) 2631-1 and 2631-5 WBV standards. This study also measured self-reported regional body pain (10-point scale), low back disability (the Oswestry Disability Index), and physical/mental health (the Short Form 12-item Health Survey). Lastly, this study evaluated associations between the WBV exposure and various health outcomes. The results showed that the predominant z-axis weighted average vibration [A(8)] measure (Mean ± SE: 0.35 ± 0.01 m/s2) was below the ISO and European Union (EU) daily exposure action limits (0.5 m/s2) whereas the vibration dose value [VDV(8)] measure (12.2 ± 0.3 m/s1.75) was above the ISO and EU daily exposure action limit (9.1 m/s1.75). Self-reported low back pain (LBP) was the most prevalent adverse musculoskeletal outcome reported (72.5%) with average LBP score of 2.9 (SD: 2.0). The SF-12 health scores showed that truck drivers’ physical health status was lower than the average US population (p’s < 0.04). Moreover, the Spearman’s correlations ( rs ) between the WBV parameters and health outcomes indicated that A(8) measures were associated with LBP ( rs = 0.31; r = 0.05) and SF-12 physical composite score ( rs = −0.39; r = 0.02); however VDV(8) was not associated with any of the health outcomes. The study findings indicates that although the impulsive exposures [VDV(8)] were more prominent, the continuous, average vibration [A(8)] appears to be more strongly associated with injury risks. This finding supports the practice of EU countries using A(8) as one of the primary measures for characterizing daily WBV exposures but also complements many other studies indicating that the current EU daily action limit value of 0.50 m/s2 for WBV may be too high.
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Álvarez-Gallardo, Inmaculada C., Alberto Soriano-Maldonado, Víctor Segura-Jiménez, Fernando Estévez-López, Daniel Camiletti-Moirón, Virginia A. Aparicio, Manuel Herrador-Colmenero, et al. "High Levels of Physical Fitness Are Associated With Better Health-Related Quality of Life in Women With Fibromyalgia: The al-Ándalus Project." Physical Therapy 99, no. 11 (August 8, 2019): 1481–94. http://dx.doi.org/10.1093/ptj/pzz113.
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Abstract Background Physical fitness is a marker of health and is associated with health-related quality of life (HRQoL). Identifying which components of physical fitness are associated with HRQoL in people with fibromyalgia may contribute to the development of more specific therapeutic strategies. Objective The 2 aims of this study were to examine the association of different components of physical fitness (ie, flexibility, muscle strength, speed and agility, and cardiorespiratory fitness) with HRQoL and to determine the extent to which any association between the components of physical fitness and HRQoL were of clinical relevance to women with fibromyalgia. Design A cross-sectional design was used. Methods This study included 466 women with fibromyalgia from southern Spain (Andalusia). The Senior Fitness Test battery and the handgrip test were used to assess physical fitness, and the 36-Item Short-Form Health Survey (SF-36) was used to assess HRQoL. Tender points, cognitive impairment, anthropometric measurements, and medication usage were also measured. First, multivariate linear regression was used to assess the individual relationship of each physical fitness test with the 8 dimensions of the SF-36. Second, a standardized composite score was computed for each component of physical fitness (flexibility, muscle strength, speed and agility, and cardiorespiratory fitness). A 1-way analysis of covariance to assess the differences in each of the 8 dimensions of the SF-36 across each physical fitness composite score was conducted. Forward stepwise regression was performed to analyze which components of physical fitness were independently associated with the SF-36 physical and mental component scales. Results Overall, higher levels of physical fitness were associated with higher levels of HRQoL (regardless of the SF-36 subscale evaluated). The effect sizes for HRQoL between participants with the lowest and the highest physical fitness levels ranged from moderate to large (Cohen d = 0.53–0.90). The muscle strength composite score was independently associated with the SF-36 physical component scale, whereas the flexibility composite score and cardiorespiratory fitness were independently associated with the SF-36 mental component scale. Limitations A limitation was that the cross-sectional design precluded the establishment of causality. Additionally, only women were included in the study, because fibromyalgia predominantly affects women. Conclusions High levels of physical fitness were consistently associated with better HRQoL in women with fibromyalgia; clinically relevant differences were demonstrated between those at extreme physical fitness levels. Muscle strength, flexibility, and cardiorespiratory fitness were independent indicators of HRQoL. These results warrant further prospective research on the potential of fitness to predict HRQoL in this population.
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Steemers, Suze, Rogier M. van Rijn, Marienke van Middelkoop, Sita M. A. Bierma-Zeinstra, and Janine H. Stubbe. "Health Problems in Conservatoire Students: A Retrospective Study Focusing on Playing-Related Musculoskeletal Disorders and Mental Health." Medical Problems of Performing Artists 35, no. 4 (December 1, 2020): 214–20. http://dx.doi.org/10.21091/mppa.2020.4029.
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OBJECTIVE: To gain insight into the prevalence and characteristics of physical health problems and mental health problems in first-, second- and third-year conservatoire students of the classical music department. Also, differences in mental health and general health were investigated between students with playing-related musculoskeletal disorders (PRMDs) and students without PRMDs. METHODS: Eighty-nine classical music students of Codarts Rotterdam, University of the Arts, were asked to complete a questionnaire targeting PRMDs (components derived from Musculoskeletal Pain Intensity and Interference Questionnaire for Musicians, MPIIQM), mental health (Mental Health Inventory-5), and self-rated general health (SF-1 from Short Form health survey SF-12). RESULTS: The response rate was 52% (n=46). Of all participants, 17.8% (n=8) had experienced PRMDs in the past 12 months and 45.7% (n=21) of the students reported poor mental health (MHI-5≤60). Students experiencing PRMDs in the past 12 months reported poorer general health compared to students without PRMDs (43.8 vs 67.1 [range 0–100], p=0.012). No significant difference was found between the groups with regard to mental health (62.0 vs 66.5 [range 0–100], p=0.522). CONCLUSION: The burden of PRMD complaints in this population of conservatoire students seems relatively low. However, the number of students facing mental problems in this population is a cause for concern. Conservatoires should focus on the subject of mental health in their curricula to increase more awareness and prevent mental problems. To investigate possible causality between PRMDs and general health, prospective studies are needed.
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Romero-Zurita, Alejandro, Ana Carbonell-Baeza, Virginia A. Aparicio, Jonatan R. Ruiz, Pablo Tercedor, and Manuel Delgado-Fernández. "Effectiveness of a Tai-Chi Training and Detraining on Functional Capacity, Symptomatology and Psychological Outcomes in Women with Fibromyalgia." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/614196.
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Background. The purpose was to analyze the effects of Tai-Chi training in women with fibromyalgia (FM).Methods. Thirty-two women with FM (mean age, years) attended to Tai-Chi intervention 3 sessions weekly for 28 weeks. The outcome measures were: tenderness, body composition, functional capacity and psychological outcomes (Fibromyalgia impact questionnaire (FIQ), Short Form Health Survey 36 (SF-36)).Results. Patients showed improvements on pain threshold, total number of tender points and algometer score (all ). The intervention was effective on 6-min walk (), back scratch (), handgrip strength (), chair stand, chair sit & reach, 8 feet up & go and blind flamingo tests (all ). Tai-Chi group improved the FIQ total score () and six subscales: stiffness (), pain, fatigue, morning tiredness, anxiety, and depression (all ). The intervention was also effective in six SF-36 subscales: bodily pain (), vitality (), physical functioning, physical role, general health, and mental health (all ).Conclusions. A 28-week Tai-Chi intervention showed improvements on pain, functional capacity, symptomatology and psychological outcomes in female FM patients.
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NICKEL, C., S. TANCA, S. KOLOWOS, F. PEDROSA-GIL, E. BACHLER, T. H. LOEW, M. GROSS, W. K. ROTHER, and M. K. NICKEL. "Men with chronic occupational stress benefit from behavioural/psycho-educational group training: a randomized, prospective, controlled trial." Psychological Medicine 37, no. 8 (December 6, 2006): 1141–49. http://dx.doi.org/10.1017/s0033291706009445.
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ABSTRACTBackgroundOverworking is one of the most frequent stressors. The purpose of this study was to determine the effectiveness of behavioural/psycho-educational group training in men who are chronically stressed from overworking.MethodOf 72 male subjects, 36 were randomly assigned to training for 8 weeks and another 36 formed the control group, which received a placebo intervention. Primary outcome measures were systolic blood pressure, salivary cortisol concentration upon awakening, and self-reported changes on the scales of the Trier Inventory for the Assessment of Chronic Stress (TICS), the State-Trait Anger Expression Inventory (STAXI) and the 36-item Short Form Health Survey (SF-36).ResultsA significant reduction in mean values was observed in daily systolic blood pressure and salivary cortisol concentration on all the TICS and most of the STAXI and SF-36 scales.ConclusionsBehavioural/psycho-educational group training appears to be effective in the treatment of men suffering from chronic stress due to overworking.
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Lodise, Thomas, Sam Colman, Elizabeth Alexander, Daniel Stein, David Fitts, Lisa Goldberg, and Jennifer Schranz. "676. Health-Related Quality of Life (HRQoL) as Measured by the 12-Item Medical Outcomes Study Short-Form (SF-12) Among Adults With Community-Acquired Bacterial Pneumonia (CABP) Who Received Either Lefamulin (LEF) or Moxifloxacin (MOX) in Two Phase 3 Randomized, Double-Blind, Double-Dummy Clinical Trials (LEAP 1 and 2)." Open Forum Infectious Diseases 6, Supplement_2 (October 2019): S308—S309. http://dx.doi.org/10.1093/ofid/ofz360.744.
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Abstract Background Interest in patient health experience as part of a benefit–risk assessment for new drug approvals is increasing. Patient-centeredness, a key metric in the 2010 Affordable Care Act, is also a growing area of focus in healthcare. LEF, a new antibiotic in development for treating adults with CABP, was noninferior to MOX based on clinical response endpoints in LEAP 1 and 2. HRQoL was prospectively incorporated and evaluated in both studies via SF-12, a well-known survey that measures general health status in 8 domains (physical function, role limitations due to physical problems, bodily pain, general health, vitality, social function, role limitations due to emotional problems, and mental health). Methods An exploratory analysis evaluated HRQoL in patients who received LEF or MOX in LEAP 1 (IV-PO treatment) and LEAP 2 (PO-only treatment). SF-12 was measured at baseline (BL) and test-of-cure (TOC; 5–10 days after last study drug dose). SF-12 outcomes assessed included the 8 domains, physical component summary (PCS), and mental component summary (MCS) scores. SF-12 scores were normalized to the 2009 US population reference mean (SD) of 50 (10). A 3-point change on any scale represents a clinically meaningful difference. Results Analysis included 1,215 patients (LEF n = 607; MOX n = 608). At BL, all mean SF-12 scores in both treatment groups were well below the US reference mean, indicating a low HRQoL level, consistent with the acute illness of the study population (figure). Clinically meaningful and significant improvements from BL to TOC were observed in all domain, PCS, and MCS scores in both groups. Mean scores were close to the reference mean, indicating an average HRQoL level. No significant differences in mean score improvements from BL to TOC were seen for LEF vs. MOX. SF-12 score improvements at TOC across predefined subgroups (age, sex, number of comorbidities, study, and PORT risk class) were comparable between treatment groups. Conclusion Our data indicate that adults with CABP experienced HRQoL improvements with LEF that were comparable with MOX, and treatment with either agent resulted in return to normal HRQoL. When combined with overall study results, these data suggest LEF as a potential alternative to MOX for treatment of adults with CABP. Disclosures All authors: No reported disclosures.
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Tobinaga, Takashi, Shigeru Obayashi, Chieko Miyazaki, Makoto Yazawa, Takamichi Saito, Kumiko Hashimoto, Masato Ogawa, Yuki Tochigi, Koichiro Oka, and Satoru Ozeki. "The impact of self-efficacy for physical activity on health-related quality of life in total knee arthroplasty recipients." Journal of Back and Musculoskeletal Rehabilitation 34, no. 5 (September 6, 2021): 829–35. http://dx.doi.org/10.3233/bmr-200017.
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BACKGROUND: Some patients with end-stage osteoarthritis of the knee remain unsatisfied after total knee arthroplasty (TKA). We postulated that to increase satisfaction, self-efficacy (SE) for physical activity should receive more attention in rehabilitative intervention, alongside the management of patient expectations, pain, and function. OBJECTIVE: We examined the relative impact of Physical Activity SE on Health-Related Quality of Life (HRQOL) alongside other factors such as pain and physical function which are well-addressed by current interventions. METHODS: One hundred and six first-TKA recipients (15 Male/91 Female, age 73.6 ± 7.2) were evaluated at 3 and 6 months post-operatively using the Medical Outcomes Study 36-Item Health Survey (SF-36v2) for HRQOL, knee extension strength measurement, Timed Up and Go test (TUG), One Leg Standing time test (OLS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for pain and function, and an instrument for measuring Physical Activity SE among the frail elderly in Japan. RESULTS: Significant improvement over pre-operative values was found at 3 and 6 months in TUG, OLS, WOMAC Pain and Function, and the 8 subscales of the SF-36v2. Factors found to significantly impact SF-36v2 subscale scores at 6 months post-operatively were found to be knee pain, knee function, and SE for physical activity. CONCLUSION: These results support our postulation that interventions to improve SE for physical activity could have comparable impact alongside interventions for knee pain and knee function, on the advancement of HRQOL among TKA recipients.
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Nicholas, Stephen J., James A. Nicholas, Calvin Nicholas, Jennifer R. Diecchio, and Malachy P. McHugh. "The Health Status of Retired American Football Players." American Journal of Sports Medicine 35, no. 10 (October 2007): 1674–79. http://dx.doi.org/10.1177/0363546507302219.
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Background Despite a perception that retired professional football players have poor health, there are little supporting data. Hypothesis Retired football players have poor health compared with age-matched population norms. Study Design Cross-sectional study; Level of evidence, 4. Methods Thirty-six of 41 members of the 1969 Super Bowl winning team were contacted 35 years after that event (3 were deceased, and no contact information was available for 2). Players completed an SF-36 health survey and a medical history and football-specific questionnaire. Each player's football-related injury history before 1969 was documented from medical records. It was estimated that there was 80% power to detect a 10% difference in physical and mental health scores between the retired football players (age, 62 ± 3 y) and population norms (n = 741) at an alpha level of 0.05. Results SF-36 scores for physical and mental health were not different from age-matched norms (physical health P = .69; mental health P = .49). The most prevalent medical conditions were arthritis (24 of 36 players), hypertension (13 of 36 players), and chronic low back pain (13 of 36 players). SF-36 physical health scores were 21% lower in players with arthritis (P < .01) and back pain (P < .05) compared with the other players. Physical health scores were 19% above normal for players without arthritis (P < .01) and not different from normal for players with arthritis (6% lower; P = .6). Four of 8 players who had major ligamentous injuries to the knee before 1969 had total knee arthroplasty in the intervening years, compared with 3 of the remaining 28 players (P < .05). The men played professional football for 8.3 ± 3.8 years, and 33 players (94%) reported having had “very fulfilling” (n = 24) or “somewhat fulfilling” (n = 9) careers. Conclusion These professional football players had long and fulfilling careers with no apparent long-term detrimental effects on physical or mental health scores despite a high prevalence of arthritis.
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Lee, Ji-yeon, Sang-Soo Shin, and So Hee Lee. "Quality of Life for North Korean Female Refugees: The Influence of Physical Health, PTSD, and Social Support." Journal for Social Action in Counseling & Psychology 11, no. 1 (December 18, 2019): 2–13. http://dx.doi.org/10.33043/jsacp.11.1.2-13.
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Background of the Study.The purpose of this study was to test a mediation model that describes the pathwaysthrough which female North Korean defectors’ perceived physical health and Post-traumatic stress disorder(PTSD) symptoms may be associated with their quality of life. Specifically, we aimed to investigate whether socialsupport would mediate the association between North Korean defectors’ perceived physical health and PTSDsymptoms and their quality of life. Methods. The study sample included 172 female North Korean defectorsliving in South Korea. Participants completed a health condition checklist, the Posttraumatic Stress DisorderChecklist-Civilian Version (PLC-C), the Multidimensional Scale of Perceived Social Support (MSPSS), andthe Korean version of the Short-Form 8-Item Health Survey (SF-8). Results. The structural equation modelconfirmed the hypothesized mediation model, with the following indices: χ2 (38) = 86.184, CFI = 0.97, NFI =0.95, TLI = 0.96, RMSEA = 0.08 (90% CI: 0.06 - 0.10). Discussion. Our findings could help counselors understandunique issues that women refugees may experience as well as protective factors in their life (i.e., social support).
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Ellis, Jennifer M., and Prabashni Reddy. "Effects of Panax Ginseng on Quality of Life." Annals of Pharmacotherapy 36, no. 3 (March 2002): 375–79. http://dx.doi.org/10.1345/aph.1a245.
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OBJECTIVE: To assess the time-dependent effects of Panax ginseng on health-related quality of life (HRQOL) by use of a general health status questionnaire. METHODS: Subjects were randomized in a double-blind manner to P. ginseng 200 mg/d (n = 15) or placebo (n = 15) for 8 weeks. The Short Form-36 Health Survey version 2 (SF-36v2), a validated general health status questionnaire, was used to assess HRQOL at baseline and at 4 and 8 weeks. HRQOL between the groups was compared by use of repeated-measures analysis of covariance. A p value <0.05 was considered statistically significant. RESULTS: There were no significant differences in baseline demographics and SF-36v2 scores between the groups. After 4 weeks of therapy, higher scores in social functioning ( P. ginseng 54.9 ± 4.6 vs. placebo 49.2 ± 6.5; p = 0.014), mental health ( P. ginseng 52.2 ± 7.7 vs. placebo 47.2 ± 7.3; p = 0.075), and the mental component summary ( P. ginseng 51.3 ± 7.4 vs. placebo 44.3 ± 8.3; p = 0.019) scales were observed in patients randomized to P. ginseng; these differences did not persist to the 8-week time point. The incidence of adverse effects was 33% in the P. ginseng group compared with 17% in the placebo group (p = 0.40). Subjects given P. ginseng (58%) were more likely to state that they received active therapy than subjects given placebo (17%; p < 0.05). CONCLUSIONS: P. ginseng improves aspects of mental health and social functioning after 4 weeks of therapy, although these differences attenuate with continued use.
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Nara, Masayuki, Shinsaku Ueda, Masashi Aoki, Tsutomu Tamada, Takuhiro Yamaguchi, and Michio Hongo. "The Clinical Utility of Makeshift Beds in Disaster Shelters." Disaster Medicine and Public Health Preparedness 7, no. 6 (December 2013): 573–77. http://dx.doi.org/10.1017/dmp.2013.107.
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AbstractObjectiveStrong earthquakes have been reported to increase the incidence of diseases. One reason for these increases may be the stress from the poor living environment for evacuees in disaster shelters. To reduce stress, makeshift cardboard beds were introduced in shelters in the Ishinomaki region, one of the areas heavily damaged by the Great East Japan Earthquake, 4 months after the earthquake. The study was performed to determine whether use of the beds offered a reduction in the disease burden.MethodsBlood pressure and blood D-dimer values, often used as diagnostic tests for venous thrombosis, were checked. The timed Up & Go (TUG) test, which assesses functional mobility; a questionnaire survey about symptoms (cough, insomnia, and lumbago); and an SF-8 health survey, a health-related quality of life survey, were also administered before and 1 month after introducing the beds.ResultsBlood pressure measurements, TUG test results, and questionnaire survey scores improved significantly 1 month after the introduction of the beds. Also, evacuees with higher blood D-dimer values tended to show improvement, suggesting that the beds may have had a good effect on persons with underlying venous thrombotic disorders.ConclusionMakeshift beds of cardboard could be very useful in disaster shelters. (Disaster Med Public Health Preparedness. 2013;7:573–577)
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Appiah, Richard, Bempah O. Tutu, Mavis E. Oman, and Peter Ndaa. "Prevalence of positive mental health and functioning among adults with sickle cell disease in Ghana." Ghana Medical Journal 54, no. 4 (December 4, 2020): 245–52. http://dx.doi.org/10.4314/gmj.v54i4.7.
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Objectives: With increasing survival rates of children with sickle cell disease (SCD) reaching adulthood, there has been a growing interest in the quality of life and mental health functioning of affected individuals. Positive mental health is recognised as a significant dimension of human health that plays an important role in advancing well-being. This study explored the prevalence of positive mental health and functioning among a sample of Ghanaian adults with SCD.
Methods: A quantitative cross-sectional survey design was implemented for data-gathering. A random sample of 62 adult SCD patients (21 to 56 years; mean age of 29 years) receiving treatment at the Sickle Cell Clinic of the Ghana Institute of Clinical Genetics at the Korle-Bu Teaching Hospital completed the Mental Health Continuum–Short Form (MHC-SF). Descriptive statistics and reliability indices were estimated for the MHC-SF. We implemented Keyes’s criteria for the assessment and categorisation of levels of mental health to determine the prevalence of positive mental health and functioning.
Results: We found a high level of positive mental health (66% flourishing; 26% moderately mentally healthy; 8% languishing) and functioning, with no significant difference between the genders. A total of 34% of the participants were functioning at suboptimal levels and were at risk of psychopathology.
Conclusion: This study gives the first overview of the prevalence of positive mental health and functioning in a clinical population in Ghana. Although the majority of participants were flourishing, contextually appropriate positive psychological interventions are needed to promote the mental health of SCD patients who are functioning at suboptimal levels, which would, inherently, also buffer against psychopathology.
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Alison, Jennifer A., Patricia Kenny, Madeleine T. King, Sharon McKinley, Leanne M. Aitken, Gavin D. Leslie, and Doug Elliott. "Repeatability of the Six-Minute Walk Test and Relation to Physical Function in Survivors of a Critical Illness." Physical Therapy 92, no. 12 (December 1, 2012): 1556–63. http://dx.doi.org/10.2522/ptj.20110410.
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Background The Six-Minute Walk Test (6MWT) is widely used as an outcome measure in exercise rehabilitation. However, the repeatability of the 6MWT performed at home in survivors of a critical illness has not been evaluated. Objective The purpose of this study was to evaluate, in survivors of a critical illness: (1) the repeatability of the 6MWT performed at home, (2) the effect on estimates of change in functional exercise capacity if only one 6MWT was performed at follow-up assessments, and (3) the relationship between the physical functioning (PF) score of the 36-Item Short-Form Health Survey questionnaire (SF-36) and the 6MWT. Design Repeated measures of the 6MWT and SF-36 were obtained. Methods Eligible participants had an intensive care unit (ICU) length of stay of ≥48 hours and were mechanically ventilated for ≥24 hours. Two 6MWTs and the SF-36 were conducted in participants' homes at weeks 1, 8, and 26 after hospital discharge. Results One hundred seventy-three participants completed the study. The participants had a mean age of 57 years (SD=16), a mean Acute Physiology and Chronic Health Evaluation II (APACHE II) score on admission of 19 (SD=10), a mean ICU length of stay of 9 days (SD=8), and a mean mechanical ventilation time of 140 hours (SD=137). Of the 173 participants, 110 performed two 6MWTs at weeks 1, 8, and 26. There were significant mean increases in 6-minute walk distance in the second test of 15 m (P<.0001) at week 1, 13 m (P<.0001) at week 8, and 9 m (P=.04) at week 26. If only one 6MWT was performed at weeks 8 and 26, the estimate of change in 6-minute walk distance from week 1 was 19 m less (P<.001) at both weeks 8 and 26. There was a moderate to strong correlation between SF-36 PF score and 6-minute walk distance at each assessment (week 1: r=.62, P<.001; week 8: r=.55, P<.001; and week 26: r=.47, P<.001). Limitations Some study participants were unable to perform a second 6MWT, and these participants may have differed in important aspects of function compared with those individuals who completed two 6MWTs. Conclusions In survivors of a critical illness, the 6MWT in the home environment should be performed twice at each assessment to give an accurate reflection of change in exercise capacity over time. The SF-36 PF score was a strong indicator of 6-minute walk distance in early recovery from a critical illness.
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Wukich, Dane K., Junho Ahn, Katherine M. Raspovic, Javier La Fontaine, and Larry A. Lavery. "Improved Quality of Life After Transtibial Amputation in Patients With Diabetes-Related Foot Complications." International Journal of Lower Extremity Wounds 16, no. 2 (April 21, 2017): 114–21. http://dx.doi.org/10.1177/1534734617704083.
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The purpose of this study was to evaluate health-related quality of life after major lower-extremity amputation in a cohort of patients with diabetes mellitus. We evaluated 81 patients with diabetes and transtibial amputation (TTA) who had a minimum of 1 year of follow-up. Of these 81 patients, 50.6% completed the Short Form Survey (SF-36) and the Foot and Ankle Ability Measure (FAAM) preoperatively and postoperatively. Outcome measures before and after TTA were compared using Welch’s ANOVA for continuous variables and Fisher’s exact test for categorical variables. There was significant improvement in all 8 subscales of the SF-36, physical component summary (PCS) score, mental component summary (MCS) score, and the FAAM. The median SF-36 PCS score improved from 26.2 to 36.6 preoperatively versus postoperatively ( P < .0005). The postoperative PCS score improved in 75.6% of patients and worsened in 24.4%. The median SF-36 MCS score improved from 43.7 to 56.1 preoperatively versus postoperatively ( P < .0005). Both the FAAM activities of daily living (ADL; P < .005) and FAAM sports scores ( P < .05) improved significantly. The postoperative FAAM general/ADL score improved in 75.6% of patients and worsened in 24.4%. Patients who were nonambulatory postoperatively had significantly lower SF-36 general health subscale scores and lower FAAM scores than patients who were ambulatory postoperatively. In select patients with nonfunctional lower extremities resulting from instability and/or chronic infection, TTA can result in significant improvement in quality of life and lower-extremity function. We acknowledge that 25% of patients had a reduction in self-reported quality of life; however, 75% of patients improved their quality of life.
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Barradas, Susana, Diego Lucumi, Diana Maria Agudelo, and Graciela Mentz. "Socioeconomic position and quality of life among Colombian hypertensive patients: The mediating effect of perceived stress." Health Psychology Open 8, no. 1 (January 2021): 205510292199693. http://dx.doi.org/10.1177/2055102921996934.
Full textAbstract:
This study aimed to assess the relationships between socioeconomic position, perceived stress and Health Related Quality of Life (HRQoL) of patients with hypertension. Data were obtained using the baseline survey of 258 patients from the Social Determinants and Inequities in the Control of Blood Hypertension Program (ProDSICHA). HRQoL was measured with SF-8 Health Survey. Socioeconomic position was measured using education, and the MacArthur Scale. Stress was measured with Perceived Stress Scale. A higher educational level was associated with a higher perception of stress (Coeff = 0.78, p = 0.019). Also, a lower position in the community was associated with a higher perception of stress (Coeff = −0.56, p = 0.027). A higher level of perceived stress was associated with a higher level of mental health (Coeff = 0.64, p = 0.000). No statistical differences were found in the relations between socioeconomic position and physical HRQoL. These findings warrant further research to understand the role of socioeconomic position in physical HRQoL.