Academic literature on the topic 'Sfingolipiden'

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Journal articles on the topic "Sfingolipiden"

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Wang, Changfu, Ping Xin, Youzhi Wang, et al. "Iridoids and sfingolipids from Hedyotis diffusa." Fitoterapia 124 (January 2018): 152–59. http://dx.doi.org/10.1016/j.fitote.2017.11.004.

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Potì, Francesco and Giva, Lavinia Beatrice. "Sfingolipidi e aterosclerosi: focus sulla Sfingosina 1-Fosfato (S1P)." Cardiologia Ambulatoriale, no. 3 (2016): 203. http://dx.doi.org/10.17473/1971-6818-2016-3-6.

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Рогожина, А. А., А. В. Алесенко, И. Н. Курочкин, et al. "Izmenenie koncentracii sfingolipidov v plazme krovi na fone gipolipidemicheskoj terapii u pacientov s rannim aterosklerozom." Вестник Российского государственного медицинского университета, no. 2021(3) (June 2021). http://dx.doi.org/10.24075/vrgmu.2021.030.

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Gipolipidemicheskie preparaty vliyayut na standartnye lipoproteiny, no kak izmenyayutsya pri lechenii drugie lipidy plazmy — ne izvestno. Cel'yu raboty bylo ocenit' dinamiku holesterina (HS), lipoproteinov vysokoj i nizkoj plotnosti (LVP i LNP), trigliceridov (TG) i sfingolipidov u pacientov s prezhdevremenno razvivshejsya ishemicheskoj bolezn'yu serdca, aterosklerozom i giperholisterinemiej na fone gipolipidemicheskoj terapii. V issledovanie vklyucheno 18 bol'nyh (srednij vozrast 53 ± 6,7 goda): v 1-j gruppe 6 pacientov poluchili startovye dozy statinov; vo 2-yu gruppu voshli 6 pacientov, ne
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Szymaszkiewicz, Kamil, Agata Szymaszkiewicz, and Jakub Fichna. "Zastosowanie modulatorów receptorów sfingozyno-1-fosforanu w leczeniu nieswoistych chorób zapalnych jelit." Postępy Biochemii, March 9, 2020. http://dx.doi.org/10.18388/pb.2020_310.

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Sfingozyno-1-fosforan (S1P) jest przedstawicielem sfingolipidów o wysokiej aktywności biologicznej. Ze względu na swój wpływ na migrację komórek odpornościowych uznawany jest za istotny element w patogenezie wielu chorób, takich jak: toczeń układowy, stwardnienie rozsiane czy nieswoiste choroby zapalne jelit (NChZJ).
 Nieswoiste choroby zapalne jelit to grupa przewlekłych i postępujących schorzeń układu pokarmowego, które przebiegają z okresami zaostrzeń i remisji. Do najczęstszych zalicza się: chorobę Leśniowskiego-Crohna (ChLC) oraz wrzodziejące zapalenie jelita grubego (WZJG). Obecnie
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Dissertations / Theses on the topic "Sfingolipiden"

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Sprong, Hein. "A role for glycosphingolipids in protein sorting." [Amsterdam] : Amsterdam : Thela Thesis ; Universiteit van Amsterdam [Host], 2001. http://dare.uva.nl/document/84491.

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Kuchař, Ladislav. "Tandemová hmotnostní spektrometrie sfingolipidů s aplikací pro metabolické studie a diagnostiku sfingolipidos." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-328211.

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In recent years, mass spectrometry (MS) become the dominant technology in lipidomic analysis and widely influenced research and diagnosis of diseases of lipid metabolism, e.g. lysosomal storage disorders (LSD) characterized by impairment of the lysosomal functions. Defects in lysosomal processing of sphingolipids SFL belong to the category of sphingolipidoses. This condition has severe and even fatal clinical outcome. The primary aim of this work was to establish quantitative and qualitative methods of SFL analysis useful for research and diagnosis of LSD. At first, semisynthesis of mass label
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Rybová, Jitka. "Patobiochemie Fabryho nemoci a dalších sfingolipidos s poruchou funkce α-galaktosidasy A". Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-297558.

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Fabry disease is an inherited defect of lysosomal α-galactosidase A (α-GALA), causing progressive accumulation of glycosphingolipids with terminal α-galactosyl moieties, especially globotriaosylceramide (Gb3Cer) and in to a small extent also galabiosylceramide (Ga2Cer) and blood group B glycolipids, in most tissues and body fluids. This diploma thesis is an extension of previous laboratory studies and intends to contribute to clarification of some specific features of catabolic pathways of glycolipids substrates in lysosomal storage disorders, especially blood group B glycolipids. Therefore, a
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Majcher, Adam. "Syntéza a hodnocení lidských 6-hydroxyceramidů." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-434371.

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Title of the Master thesis: Synthesis and evaluation of human 6-hydroxyceramides Candidate: Adam Majcher Supervisor: PharmDr. Lukáš Opálka, Ph.D. Consultant: PharmDr. Andrej Kováčik, Ph.D. Charles University, Faculty of Pharmacy in Hradec Králové Skin Barrier Research Group, Department of Organic and Bioorganic Chemistry Ceramides (Cer), the members of sphingolipid family, occur in all human cells and play an important role in cell signaling. In high concentrations, Cer can also be found in the uppermost layer of epidermis called stratum corneum, along with free fatty acids and cholesterol (in
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Yanok, Oksana. "Vliv glukosylsfingosinu na bariérovou funkci kůže a komplexního lipidového modelu kůže." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-448530.

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Charles University Faculty of Pharmacy in Hradec Králové Department of pharmeceutical technology Candidate: Oksana Yanok Supervisor: Pharm.Dr. Andrej Kováčik, Ph.D. Title of Diploma Thesis: The effects of glucosyl sphingosine on barrier function of skin and complex skin model. The skin barrier, which provides protection from water loss and harmful environmental influences is located in the stratum corneum. The dominant group of lipids within the stratum corneum are ceramides (Cer), which also have the most important role in ensuring the barrier properties of the skin. The enzymes sphingomyelin
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Blahová, Tereza. "Genová exprese enzymů zapojených v regulaci apoptózy v myokardu potkana - vliv chronické a akutní hypoxie." Master's thesis, 2014. http://www.nusl.cz/ntk/nusl-337160.

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Adaptation to chronic hypoxia provides myocardial protection against ischemia - reperfusion injury (IR). Cardioprotective effect of adaptation depends on the degree and duration of hypoxic exposure and daily regime of adaptation. Certain protective regimes of adaptations to hypoxia have been reported to activate proapoptotic signaling pathways and bioactive sphingolipids were recently shown to play important role in the regulation of apoptosis in the heart. We aimed to determine the mRNA level of selected genes related to apoptotic pathways and to sphingolipid metabolism in two models of hypox
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