To see the other types of publications on this topic, follow the link: SGAB.
Journal articles on the topic 'SGAB'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'SGAB.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Zhang, Zhongge, Mohammad Aboulwafa, Meghan H. Smith, and Milton H. Saier,. "The Ascorbate Transporter of Escherichia coli." Journal of Bacteriology 185, no. 7 (2003): 2243–50. http://dx.doi.org/10.1128/jb.185.7.2243-2250.2003.
Full textAbstract:
ABSTRACT The sgaTBA genes of Escherichia coli encode a putative 12-transmembrane α-helical segment (12 TMS) transporter, an enzyme IIB-like protein and an enzyme IIA-like protein of the phosphotransferase system (PTS), respectively. We show that all three proteins as well as the energy-coupling PTS proteins, enzyme I and HPr, are required for the anaerobic utilization and uptake of l-ascorbate in vivo and its phosphoenolpyruvate-dependent phosphorylation in vitro. The transporter exhibits an apparent Km for l-ascorbate of 9 μM and is highly specific. The sgaTBA genes are regulated at the transcriptional level by the yjfQ gene product, as well as by Crp and Fnr. The yjfR gene product is essential for l-ascorbate utilization and probably encodes a cytoplasmic l-ascorbate 6-phosphate lactonase. We conclude that SgaT represents a novel prototypical enzyme IIC that functions with SgaA and SgaB to allow phosphoryl transfer from HPr(his-P) to l-ascorbate via the phosphoryl transfer pathway: PEP → enzyme I-P → HPr-P → IIA- \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\stackrel{\mathrm{SgaA}}{\mathrm{P}}\) \end{document} → IIB- \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\stackrel{\mathrm{SgaB}}{\mathrm{P}}\) \end{document} \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\stackrel{\textstyle{\mathrm{IIC^{SgaT}}}}{{\rightarrow}}\) \end{document} l-ascorbate-6-P.
2
Ponraj, Diana Salomi, Thomas Falstie-Jensen, Nis Pedersen Jørgensen, Christen Ravn, Holger Brüggemann, and Jeppe Lange. "Diagnosis of orthopaedic-implant-associated infections caused by slow-growing Gram-positive anaerobic bacteria – a clinical perspective." Journal of Bone and Joint Infection 6, no. 8 (2021): 367–78. http://dx.doi.org/10.5194/jbji-6-367-2021.
Full textAbstract:
Abstract. Slow-growing Gram-positive anaerobic bacteria (SGAB) such as Cutibacterium acnes are increasingly recognized as causative agents of implant-associated infections (IAIs) in orthopaedic surgeries. SGAB IAIs are difficult to diagnose because of their non-specific clinical and laboratory findings as well as the fastidious growth conditions required by these bacteria. A high degree of clinical suspicion and awareness of the various available diagnostic methods is therefore important. This review gives an overview of the current knowledge regarding SGAB IAI, providing details about clinical features and available diagnostic methodologies. In recent years, new methods for the diagnosis of IAI were developed, but there is limited knowledge about their usefulness in SGAB IAI. Further studies are required to determine the ideal diagnostic methodology to identify these infections so that they are not overlooked and mistakenly classified as aseptic failure.
3
Zinser, Erik R., and Roberto Kolter. "Mutations Enhancing Amino Acid Catabolism Confer a Growth Advantage in Stationary Phase." Journal of Bacteriology 181, no. 18 (1999): 5800–5807. http://dx.doi.org/10.1128/jb.181.18.5800-5807.1999.
Full textAbstract:
ABSTRACT Starved cultures of Escherichia coli undergo successive rounds of population takeovers by mutants of increasing fitness. These mutants express the growth advantage in stationary phase (GASP) phenotype. Previous work identified the rpoS819 allele as a GASP mutation allowing cells to take over stationary-phase cultures after growth in rich media (M. M. Zambrano, D. A. Siegele, M. A. Almirón, A. Tormo, and R. Kolter, Science 259:1757–1760, 1993). Here we have identified three new GASP loci from an aged rpoS819 strain: sgaA, sgaB, and sgaC. Each locus is capable of conferring GASP on therpoS819 parent, and they can provide successively higher fitnesses for the bacteria in the starved cultures. All four GASP mutations isolated thus far allow for faster growth on both individual and mixtures of amino acids. Each mutation confers a growth advantage on a different subset of amino acids, and these mutations act in concert to increase the overall catabolic capacity of the cell. We present a model whereby this enhanced ability to catabolize amino acids is responsible for the fitness gain during carbon starvation, as it may allow GASP mutants to outcompete the parental cells when growing on the amino acids released by dying cells.
4
Hutmacher, Walo. "Ziele und mögliche Handlungsstrategien der SGAB/SRFP." BzL - Beiträge zur Lehrerinnen- und Lehrerbildung 5, no. 2 (1987): 119–22. http://dx.doi.org/10.36950/bzl.5.2.1987.3.
Full text
5
Zhang, Xiaohu, and Haifeng Huang. "PSNet: Parallel-Convolution-Based U-Net for Crack Detection with Self-Gated Attention Block." Applied Sciences 13, no. 17 (2023): 9875. http://dx.doi.org/10.3390/app13179875.
Full textAbstract:
Crack detection is an important task for road maintenance. Currently, convolutional neural-network-based segmentation models with attention blocks have achieved promising results, for the reason that these models can avoid the interference of lights and shadows. However, by carefully examining the structure of these models, we found that these segmentation models usually use down-sampling operations to extract high-level features. This operation reduces the resolution of features and causes feature information loss. Thus, in our proposed method, a Parallel Convolution Module (PCM) was designed to avoid feature information loss caused by down-sampling. In addition, the attention blocks in these models only focused on selecting channel features or spatial features, without controlling feature information flow. To solve the problem, a Self-Gated Attention Block (SGAB) was used to control the feature information flow in the attention block. Therefore, based on the ideas above, a PSNet with a PCM and SGAB was proposed by us. Additionally, as there were few public datasets for detailed evaluation of our method, we collected a large dataset by ourselves, which we named the OAD_CRACK dataset. Compared with the state-of-the-art crack detection method, our proposed PSNet demonstrated competitive segmentation performance. The experimental results showed that our PSNet could achieve accuracies of 92.6%, 81.2%, 98.5%, and 76.2% against the Cracktree200, CRACK500, CFD, and OAD_CRACK datasets, respectively, which were 2.6%, 4.2%, 1.2%, and 3.3% higher than those of the traditional attention models.
6
Alkali, G., M. D. Alegbejo, B. D. Kashina, and O. O. Banwo. "Analysis of Serological Variability and Hierarchical Distribution of Rice Yellow Mottle Sobemovirus Isolates in Northern Nigeria." International Letters of Natural Sciences 37 (April 2015): 1–9. http://dx.doi.org/10.18052/www.scipress.com/ilns.37.1.
Full textAbstract:
A panel of four monoclonal antibodies (MAbs) was used to study the immunological profile of Rice yellow mottle virus (RYMV) genus Sobemovirus. Serological profiles of 35 representative isolates of RYMV from Borno, Gombe, Kaduna, Kano, Niger, Sokoto and Zamfara states in Northern Nigeria. All the RYMV isolates were classified into three major serogroups (SG1, SG2 and SG3) and further separated into six subgroups (Sg1a, Sg1b, Sg2a, Sg2b, Sg3a and Sg3b). The results demonstrate a significant serological variability among RYMV isolates in Northern Nigeria. The hierarchical analysis of the serological profiles data revealed high viral load in Kano, Kaduna and Gombe states, these show they are suitable locations for strategic RYMV diagnostic and field epidemiological studies
7
Alkali, G., M. D. Alegbejo, B. D. Kashina, and O. O. Banwo. "Analysis of Serological Variability and Hierarchical Distribution of Rice Yellow Mottle Sobemovirus Isolates in Northern Nigeria." International Letters of Natural Sciences 37 (April 3, 2015): 1–9. http://dx.doi.org/10.56431/p-6qomwi.
Full textAbstract:
A panel of four monoclonal antibodies (MAbs) was used to study the immunological profile of Rice yellow mottle virus (RYMV) genus Sobemovirus. Serological profiles of 35 representative isolates of RYMV from Borno, Gombe, Kaduna, Kano, Niger, Sokoto and Zamfara states in Northern Nigeria. All the RYMV isolates were classified into three major serogroups (SG1, SG2 and SG3) and further separated into six subgroups (Sg1a, Sg1b, Sg2a, Sg2b, Sg3a and Sg3b). The results demonstrate a significant serological variability among RYMV isolates in Northern Nigeria. The hierarchical analysis of the serological profiles data revealed high viral load in Kano, Kaduna and Gombe states, these show they are suitable locations for strategic RYMV diagnostic and field epidemiological studies
8
Ackermann, Nicole. "Didaktische Implikationen einer Grossreform: «Kaufleute 2022»." Transfer: Berufsbildung in Forschung und Praxis, no. 2 (August 1, 2021): 1–4. https://doi.org/10.5281/zenodo.5356750.
Full textAbstract:
Mit der Reform «Kaufleute 2022» soll die kaufmännische Grundbildung den veränderten Anforderungen der globalen und digitalen Arbeitswelt angepasst werden. Die Ausbildung der Lernenden soll an allen drei Lernorten konsequent auf die Förderung und Überprüfung beruflicher Handlungskompetenzen ausgerichtet werden. Der lernortübergreifende und kompetenzorientierte Ansatz stellt einen Paradigmenwechsel dar. Dieser Beitrag analysiert didaktische Implikationen der Reform «Kaufleute 2022» für die kaufmännischen Berufsfachschulen und für die Lehrpersonenbildung.
9
Elly S, As, and Rani Refianti. "KEMAMPUAN GENERALISASI MATEMATIS MELALUI PENDEKATAN KETERAMPILAN METAKOGNITIF DI SMP NEGERI MEGANG SAKTI." Jurnal Perspektif Pendidikan 16, no. 1 (2022): 44–51. http://dx.doi.org/10.31540/jpp.v16i1.1569.
Full textAbstract:
Penelitian ini bertujuan untuk melihat pengaruh pendekatan keterampilan metakognitif pada pembelajaran matematika terhadap kemampuan generalisasi matematis siswa SMP Negeri Megang sakti. Jenis penelitian yang digunakan adalah penelitian semu experimental. Penelitian ini dilakukan pada kelas VII1 sebagai kelas experiment dan kelas VII2 sebagai kelas control. Populasi dalam penelitian ini seluruh siswa kelas VII SMP Negeri Megang Sakti. Kelas experiment menggunkan pendekatan metakognitif dan kelas control menggunkan pembelajaran konvensional. Metode pengumpulan data yang digunakan adalah metode Teknik tes. Data dianalisis menggunakan uji-t. Berdasarkan analisis tes akhir diperoleh nilai rata-rata kelas eksperimen sebesar 80,06 dan kelas kontrol sebesar 67,24 dengan Sgab = 9,65, berdasarkan perhitungan pada uji hipotesis didapatkan nilai thitung = 5,323 ttabel = 1,669. Sehingga dapat disimpulkan bahwa terdapat pengaruh pendekatan keterampilan Metakognitif dalam pembelajaran metematika terhadap kemampuan Generalisasi matematika siswa di SMP Negeri Megang Sakti.
10
Chong, Yue Linn, Christina Dao Wen Lee, Liushifeng Chen, Chongjiang Shen, Ken Kok Hoe Chan, and Marcelo H. Ang. "Online Obstacle Trajectory Prediction for Autonomous Buses." Machines 10, no. 3 (2022): 202. http://dx.doi.org/10.3390/machines10030202.
Full textAbstract:
We tackle the problem of achieving real-world autonomous driving for buses, where the task is to perceive nearby obstacles and predict their motion in the time ahead, given current and past information of the object. In this paper, we present the development of a modular pipeline for the long-term prediction of dynamic obstacles’ trajectories for an autonomous bus. The pipeline consists of three main tasks, which are the obstacle detection task, tracking task, and trajectory prediction task. Unlike most of the existing literature that performs experiments in the laboratory, our pipeline’s modules are dependent on the introductory modules in the pipeline—it uses the output of previous modules. This best emulates real-world autonomous driving and reflects the errors that may accumulate and cascade from previous modules with less than 100% accuracy. For the trajectory prediction task, we propose a training method to improve the module’s performance and attain a run-time of 10 Hz. We present the practical problems that arise from realising ready-to-deploy autonomous buses and propose methods to overcome these problems for each task. Our Singapore autonomous bus (SGAB) dataset evaluated the pipeline’s performance. The dataset is publicly available online.
11
Ali, Muhammad Munwar, Muhammad Asif Khaskheli, Inayatullah Awan, Khairunisa Shaikh, Safdar Hussain Arain, and Abrar Shaikh. "Neuropathophysiological Mechanisms and Treatment Strategies for Post-Traumatic Epilepsy." Pakistan Journal of Medical and Health Sciences 16, no. 11 (2022): 169–71. http://dx.doi.org/10.53350/pjmhs20221611169.
Full textAbstract:
Aim: To understand and analyze neuropathophysiological mechanisms and treatment strategies for post traumatic epilepsy. Study design: Cohort clinical trial study Place and duration of study: Department of Neurosurgery, Chandka Medical College Hospital, Larkana 1st January 2021 to 31st March 2022. Methodology: One hundred and twenty cases of traumatic brain injury were enrolled. In 1st sub group there was 20 cases were given either Sodium valproate (SG1a) while 20 were given its placebo (SG1b). Similarly in subgroup 2nd and 3rd, each had 20 cases who were given Levetiracetam (SG2a) or Phenytoin (SG3a) respectively or other given its respective placebo (n=20/SG2b, SG3b). Primary and secondary outcomes were measured. Results: The mean age was 30.1±3.3 years. There was almost equal number of both genders with slightly higher number of males than females with no significant variance. Around 40.83% of the cases were suffering from traumatic brain injury as a result of fall from a higher/raised building or structure. Conclusion: The sodium valproate had a highest efficacy in controlling of the post-traumatic brain injury epileptic seizure not only for a short duration but for longer duration as well. Keywords: Treatment strategies, Post-traumatic epilepsy, Neuropathophysiological mechanisms
12
Wahyuningtyas, Ramadhani, and Zulherman. "Model Pembelajaran Kooperatif Type Index Card Match Terhadap Hasil Belajar IPA Kelas IV SD." Journal of Instructional and Development Researches 2, no. 3 (2022): 88–94. http://dx.doi.org/10.53621/jider.v2i3.130.
Full textAbstract:
Penelitian ini bertujuan untuk mengetahui adanya pengaruh hasil belajar IPA dengan menggunakan model pembelajaran kooperatif type Index Card Match pada siswa kelas IV SDN Jatiwaringin III Pondok Gede pada semester 2 tahun ajaran 2018-2019. Metode penelitian yang digunakan adalah metode kuantitatif dengan desain penelitian Posttest-Only Control Design. Sampling yang digunakan pada penelitian ini adalah teknik sampling Non Probability sampling yaitu sampling jenuh. Pada uji validitas dengan menggunakan Korelasi Point Biserial sebanyak 50 soal. Data dianalisis menggunakan uji persyaratan normalitas dengan meggunakan uji Liliefors diperoleh pada kelas eksperimen Lo 0,14 < Lhitung 0,161, pada kelas kontrol Lo 0,15 < Lhitung 0,161. Maka dapat disimpulkan bahwa data dari kedua kelompok berdistribusi normal. Selanjutnya uji homogenitas dengan menggunakan uji homogenitas dua variabel independent dengan uji F diperoleh Fhitung sebesar 1,12 dengan Sx12 = 82,80 dan Sx22 = 73,82 dan Ftabel = 1,85. Fhitung (1,12) < Ftabel (1,85) maka dapat disimpulkan bahwa varians kedua kelompok homogen. Pada uji hipotesis digunakan uji-t diperoleh thitung = 3,824 dengan Sgab = 8,85 pada taraf signifikan α 0,05 drajat kebebasan (dk) = 58 seharga 2,002. Karena thitung (3,824) > ttabel ( 2,002). Maka dapat disimpulkan bahwa Ho ditolak dan H1 diterima. Data tersebut dinyatakan bahwa terdapat pengaruh yang signifikan pada pembelajaran dengan menggunakan model kooperatif type Index Card Match terhadap hasil belajar IPA siswa kelas IV SDN Jatiwaringin III Pondok Gede.
13
Sanchez-Vargas, Irma, Ken Olson, and William Black. "The Genetic Basis for Salivary Gland Barriers to Arboviral Transmission." Insects 12, no. 1 (2021): 73. http://dx.doi.org/10.3390/insects12010073.
Full textAbstract:
Arthropod-borne viruses (arboviruses) infect mosquito salivary glands and then escape to saliva prior to virus transmission. Arbovirus transmission from mosquitoes can be modulated by salivary gland infection barriers (SGIBs) and salivary gland escape barriers (SGEBs). We determined the influence of SGIBs and SGEBs by estimating the quantitative genetic contributions of Aedes aegypti half-sib families (Mapastepec, Mexico) infected with three dengue 2 (DENV2), two chikungunya (CHIKV), and two Zika (ZIKV) genotypes. We determined virus titer per salivary gland and saliva at seven days post-infection and virus prevalence in the half-sib population. CHIKV or ZIKV genotypes did not present SGIB, whereas DENV2 genotypes showed low rates of SGIB. However, virus titer and prevalence due to additive genetic factors in the half-sib family displayed a significant narrow-sense heritability (h2) for SGIB in two of the three DENV2 genotypes and one CHIKV and one ZIKV genotype. SGEBs were detected in all seven virus strains: 60–88% of DENV2 and 48–62% of CHIKV or ZIKV genotype infections. SGEB h2 was significant for all CHIKV or ZIKV genotypes but not for any of the DENV2 genotypes. SGIBs and SGEBs exhibited classical gene-by-gene interaction dynamics and are influenced by genetic factors in the mosquito and the virus.
14
Liu, Wen, and Ben Shen. "Genes for Production of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus Are Clustered with the cagA Gene That Encodes the C-1027 Apoprotein." Antimicrobial Agents and Chemotherapy 44, no. 2 (2000): 382–92. http://dx.doi.org/10.1128/aac.44.2.382-392.2000.
Full textAbstract:
ABSTRACT C-1027, the most potent member of the enediyne antitumor antibiotic family, is produced by Streptomyces globisporus C-1027 and consists of an apoprotein (encoded by the cagA gene) and a nonpeptidic chromophore. The C-1027 chromophore could be viewed as being derived biosynthetically from a benzoxazolinate, a deoxyamino hexose, a β-amino acid, and an enediyne core. By adopting a strategy for cloning of the C-1027 biosynthesis gene cluster by mapping a putative dNDP-glucose 4,6-dehydratase (NGDH) gene to cagA, we have localized 75 kb of contiguous DNA from S. globisporus. DNA sequence analysis of two regions of the cloned gene cluster revealed two genes, sgcA and sgcB, that encode an NGDH enzyme and a transmembrane efflux protein, respectively, and confirmed that the cagA gene resides approximately 14 kb upstream of the sgcAB locus. The involvement of the cloned gene cluster in C-1027 biosynthesis was demonstrated by disrupting the sgcA gene to generate C-1027-nonproducing mutants and by complementing the sgcAmutants in vivo to restore C-1027 production. These results represent the first cloning of a gene cluster for enediyne antitumor antibiotic biosynthesis and provide a starting point for future genetic and biochemical investigations of C-1027 biosynthesis.
15
Buckley, Peter F. "Effective Dosing and Dose Equivalency of Second-Generation Antipsychotic Medications." CNS Spectrums 9, S9 (2004): 24–31. http://dx.doi.org/10.1017/s1092852900004375.
Full textAbstract:
ABSTRACTDosing patterns with second-generation antipsychotic medications (SGAs) are dynamic, with some SGAs surpassing current recommendations while others are declining in dose since their initial regulatory guidelines. Pertinent recent studies and available pharmacoepidemiologic reports, information, and expert consenses are reviewed herein to illuminate current thinking on the topic of dosing with SGAs. There is a need for fixed-dose studies of each SGA. Additionally, dosing should be a primary consideration when designing and subsequently interpreting comparative studies between SGAs.
16
Günüç, A. Hilmi, Aysel Mercan, and Atilla Erol. "Supraglottik Hava Yolu Aracını Çıkarma Zamanlamasında Konvansiyonel ve Ultrasonografik Yöntemlerin Karşılaştırılması." Journal of Anesthesiology and Reanimation Specialists' Society 32, no. 3 (2024): 140–46. http://dx.doi.org/10.54875/jarss.2024.85579.
Full textAbstract:
Objective: The supraglottic airway device (SGAD), which is widely used in anesthesia practice, is a safe method. The timing of SGAD removal is still controversial. The aim of this study was to compare conventional and ultrasonographic methods in deciding the timing of removal in patients with SGAD placement under general anesthesia. Methods: One hundred patients who underwent surgery under general anesthesia in a university hospital and underwent SGAD placement were included in the study. During the awakening process, patients were divided into two groups: the conventional group and the USG group. In the USG group, diaphragm thickness was recorded preoperatively and intraoperatively before SGAD removal. In the ultrasonography (USG) group, the SGAD was removed in patients with a diaphragmatic thickness (Δtdi) ratio of 20% or more in the USG measurement of the diaphragm. In the conventional group, SGAD removal was decided after eye opening, obeying orders, spontaneous or commanded breathing that produced >4 mL kg-1 tidal volume. Patients in both groups were compared in terms of SpO2 values, SGAD removal time, hemodynamic changes and postoperative complications. Results: There was no statistically significant difference between the groups in terms of completion of the operation and duration of anesthesia. No statistically significant difference was observed between the SGAD removal times in both groups. Heart rate, mean arterial pressure, systolic arterial pressure, diastolic arterial pressure and peripheral oxygen saturation values were similar in preoperative, intraoperative and postoperative periods between the groups. There was no difference in complication status in the postoperative period. Conclusion: Conventional methods do not have sufficient objectivity in deciding the time of SGAD removal in patients with SGAD placement. Ultrasonographic evaluation of diaphragmatic thickening has not been shown to be superior to the conventional method of deciding the timing of SGAD removal. However, the use of USG has the advantage of collecting measurable and objective data independent of the anesthesia provider. The lack of significant difference between the two groups may be explained by the experience of the clinician making the decision with the conventional method, and ultrasonographic evaluation may provide additional information to inexperienced users. Further studies are needed in other surgical procedures, risk groups and age groups to determine whether the use of USG in extubation decision-making would be useful. Keywords: Supraglottic airway, diaphragm, ultrasonography, extubation
17
Fairshter, R. D., R. B. Berry, A. F. Wilson, and J. E. Lowe. "Time dependence of airways and lung parenchymal recoil hysteresis." Journal of Applied Physiology 61, no. 1 (1986): 248–54. http://dx.doi.org/10.1152/jappl.1986.61.1.248.
Full textAbstract:
Hysteresis of airways and lung parenchymal recoil was examined in normal subjects by measuring specific conductance (sGaw) and lung elastic recoil (Pst,L) before and 5, 10, 15, and 30 s after deep inspiration (DI). Routine lung function tests were normal before and after inhaled metaproterenol. sGaw increased significantly for 10 s after DI. Also, sGaw(DI) was greater than sGaw in 11 of 12, 8 of 12, 7 of 12, and 6 of 12 subjects at 5, 10, 15, and 30 s, respectively, after DI. The response of sGaw to DI and metaproterenol correlated significantly with each other (r = 0.82, P less than 0.001). However, after metaproterenol, sGaw(DI) did not exceed sGaw. Pst,L decreased significantly for 15 s after DI, with the lowest measured Pst,L(DI) values occurring 5 s after DI (P less than 0.01–0.001). Both sGaw(DI) and Pst,L(DI) values returned to base line (preinspiration) in a time-dependent exponential manner, with time constants of 9.2 +/- 4.9 and 11.3 +/- 6.1 s, respectively; these time constants were not significantly different from each other. We conclude that airways hysteresis is the predominant finding in normal subjects (even without prior pharmacological bronchoconstriction) before but not after metaproterenol; Pst,L decreases after DI and, in normal individuals, returns to base line in a time-dependent manner; and the time-dependent behavior of airways and lung parenchymal hysteresis have opposite (and unequal) effects on airway caliber.
18
Little, C. B., B. J. Hilbert, S. Wickstrom, and B. E. Hedlund. "Quantitative microanalysis of equine synovial fluid glycosaminoglycan concentration." American Journal of Veterinary Research 51, no. 10 (1990): 1534–39. http://dx.doi.org/10.2460/ajvr.1990.51.10.1534.
Full textAbstract:
SUMMARY An alcian blue precipitation method for quantifying the hyaluronic acid (ha) and sulphated glycosaminoglycan concentration (sgag) in solutions containing both compounds was assessed. The assay was found to be rapid and reliable in solutions containing 0 to 200 mg of ha/dl and 50 to 1,000 μg of sgag/dl, and was not affected by the presence of protein, hemoglobin, or methemoglobin in concentrations normally found in synovial fluid. The ha and sgag concentrations in intercarpal synovial fluid from 13 clinically normal and 11 arthritic horses were evaluated. A relationship was not found between the concentration of ha and sgag and any other synovial fluid variable. The sgag concentration was found to be markedly high in several of the synovial fluid samples from arthritic horses, but did not correlate with the degree of articular cartilage erosion.
19
Semenova, Anastasiya Vladimirovna, Vladimir Georgiyevich Gol'dshteyn, Vladimir Alekseyevich Degtyarev, Anastasiya Alekseyevna Morozova, and Lidiya Borisovna Kuzina. "ISOLATION OF STEROIDAL GLYCOALKALOIDS FROM POTATO PEEL BY ACID EXTRACTION." chemistry of plant raw material, no. 2 (June 26, 2023): 269–78. http://dx.doi.org/10.14258/jcprm.20230211355.
Full textAbstract:
The peel of a potato contains many biologically active compounds of various directions, which can be extracted for further use. The peel contains the largest amount of steroidal glycoalkaloids (SGAs) of potato, the extraction of which may be interesting for protecting plants from pests, as well as for the development of pharmaceuticals. The article studied the mechanisms that affect the accumulation and activity of SGAs in plants. Possibilities of their isolation from the potato peel by the acid method with the study of the effect of extraction factors on the yield of SGAs were studied. The object of the study was potato varieties Nakra and Kometa with the content of SGAs 422 and 251 mg/kg of potatoes. The concentration of compounds that passed into the solution was estimated by the spectrophotometric method. The possibility of reusing extracts on new peel masses has been established. When the extracts were concentrated by evaporation, the content of SGAsin them increased markedly. As a result of acid extraction, 200–1000 mg of SGAs/kg of peel (0.20–0.60 mg of SGAs/ml of extract) were extracted. Нydromodulus is a significant factor of acid extraction of SGAs. However, acid concentration and temperature can also influence the extraction process. The most optimal parameters for the process of extraction of steroidal glycoalkaloids with dilute sulfuric acid were established: acid hydromodulus 2.3, temperature 55 °C, acid concentration 0.1%, and extraction duration 30 min.
20
Fairshter, R. D. "Airway hysteresis in normal subjects and individuals with chronic airflow obstruction." Journal of Applied Physiology 58, no. 5 (1985): 1505–10. http://dx.doi.org/10.1152/jappl.1985.58.5.1505.
Full textAbstract:
Specific conductance (sGaw) was measured without prior pharmacological induction of bronchoconstriction before and 5–10 s after a total lung capacity (TLC) volume history in normal subjects and in individuals with chronic airflow obstruction (CAO); increased sGaw after inspiration to TLC was considered evidence of airway hysteresis. Lung elastic recoil [Pst(L)] was also measured before and after inspiration to TLC. In the normal subjects 1) prebronchodilator sGaw increased significantly, whereas Pst(L) decreased significantly after inspiration to TLC; 2) modulators of cyclooxygenase activity had no significant effects on sGaw responses to deep inspiration; and 3) airway hysteresis diminished after inhalation of atropine or metaproterenol. In the CAO group 1) prebronchodilator sGaw and Pst(L) decreased significantly after inspiration to TLC, and 2) bronchoconstriction after deep inspiration diminished after inhalation of atropine or metaproterenol. This study demonstrates that normal airways exhibit hysteresis even without alteration of resting airway tone and that airway hysteresis is impaired in CAO.
21
Chinet, T., G. Pelle, I. Macquin-Mavier, H. Lorino, and A. Harf. "Comparison of the dose-response curves obtained by forced oscillation and plethysmography during carbachol inhalation." European Respiratory Journal 1, no. 7 (1988): 600–605. http://dx.doi.org/10.1183/09031936.93.01070600.
Full textAbstract:
We compared the cumulative dose-response curves obtained during carbachol inhalation by simultaneous measurements of airway specific conductance (sGaw) and respiratory conductance, in 23 subjects with or without bronchial hyperresponsiveness. The sGaw was measured by a body plethysmograph, whilst the random noise forced oscillation technique (FOT) was used to determine respiratory conductance. The sGaw was compared to respiratory conductance extrapolated to zero frequency (Grs0). Bronchial sensitivity was assessed by the threshold dose of carbachol (TD) that induced a decrease in sGaw and Grs0 of twice the baseline coefficient of variation. Bronchial responsiveness was assessed by the slopes (S) of the individual dose-response curves. The TD and S values obtained by FOT and by plethysmography were closely correlated (p less than 0.001). The carbachol doses inducing a 50% reduction in sGaw were equivalent to those causing a 42% reduction in Grs0 (r = 0.90; p less than 0.001). During bronchial challenge testing, FOT provides comparable information in terms of bronchial sensitivity and responsiveness to that supplied by plethysmography.
22
Tú, Giang Cẩm, Mai Tấn Đạt та Ngô Thanh Nhàn. "Phân lập và nhận diện một số dòng vi sinh vật có hoạt tính sinh học phân giải lipid trong nước thải của các cơ sở chế biến thủy sản". Journal of Science and Technology 1, № 3 (2018): 38–43. http://dx.doi.org/10.55401/jst.v1i3.176.
Full textAbstract:
Đề tài “Phân lập một số dòng vi sinh vật có hoạt tính sinh học phân giải lipid trong nước thải của các cơ sở chế biến thủy sản” với mục tiêu xác định được các dòng vi sinh vật có khả năng phân giải được lipid có trong nước thải của các công ty chế biến thủy sản. Các thí nghiệm được bố trí theo kiểu hoàn toàn ngẫu nhiên. Qua 6 mẫu nước thải thu từ 3 công ty: Công ty Cổ phần Kinh doanh Thủy Hải sản Sài Gòn, Công ty TNHH Chế biến Thủy sản Thanh Hải, Công ty Cổ phần Chế biến Thủy sản Trung Sơn và 8 mẫu nước thải từ Công ty Thủy sản Miền Nam, Cần Thơ phân lập được 33 dòng vi sinh vật. Trong số 33 dòng vi sinh vật phân lập được, sau khi kiểm tra hoạt tính phân giải lipid có 22 dòng có khả năng kết tủa tạo vòng halo trên môi trường Tween 20, chứng tỏ 22 dòng vi sinh vật này có khả năng sinh lipase, chiếm tỉ lệ: 66,6% (22/33). Trong đó có 5 dòng có khả năng phân giải lipid cao là: TSB1, SGA1, SGA2; M1A2-2 và M2A2-1. 5 dòng triển vọng này, sau khi giải trình tự 16S rRNA định danh được 3 dòng vi khuẩn là Pseudomonas otitidis, Pseudomonas aeruginosa và Acinetobacter tandoii.
23
Wasylyshen, Adrian, and Andrew M. Williams. "Second-generation antipsychotic use in borderline personality disorder: What are we targeting?" Mental Health Clinician 6, no. 2 (2016): 82–88. http://dx.doi.org/10.9740/mhc.2016.03.82.
Full textAbstract:
Abstract Introduction: Borderline personality disorder (BPD) is a personality disorder plagued with high rates of psychotropic polypharmacy. Estimates show that second-generation antipsychotics (SGAs) are used in most of these patients; however, they are being prescribed off label. Methods: A literature review was conducted via PubMed in search for studies evaluating SGA use in BPD. Results: There are available data investigating 8 of 11 SGAs and their use in BPD. Of N = 269 potential articles, N = 34 evaluating the use of SGAs in BPD were included. Discussion: Strong evidence supporting SGAs in BPD is lacking. Potential target symptoms in which a SGA may be useful include depression, anxiety, anger, impulsivity, and paranoia/dissociative behavior.
24
Sakaue, Yuta, Jun Ueda, Masaaki Seki, et al. "Evaluation of the New Digital Goldmann Applanation Tonometer for Measuring Intraocular Pressure." Journal of Ophthalmology 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/461681.
Full textAbstract:
Purpose. To compare a new digital Goldmann applanation tonometer (dGAT) that measures intraocular pressure (IOP) in 0.1 mmHg increments to a standard Goldmann applanation tonometer (sGAT).Methods. This study included 116 eyes of 60 subjects. A single examiner first measured IOP in triplicate using either sGAT or dGAT, which was randomly chosen. After a 5-minute interval, the next set of three consecutive IOP was measured using the other GAT.Results. The mean IOP measured with sGAT was 16.27 ± 6.68 mmHg and 16.35 ± 6.69 mmHg with dGAT. Pearson’s correlation coefficient was 0.998 (P<0.01). The subjects were divided into three groups based on the mean IOP: IOP < 14 mmHg, 14–20 mmHg, or >20 mmHg. The Pearson’s correlation coefficient within each group was 0.935, 0.972, and 0.997 (P<0.01), respectively. The difference within the three consecutive IOP measurements (maximum–minimum) for dGAT (0.72 ± 0.34 mmHg) was significantly smaller than those with sGAT (0.92 ± 0.42 mmHg,P<0.01). Even in patients with equal IOP (zero left-right difference) with sGAT (n=30), dGAT detected IOP differences between the left and right eyes (0.47 ± 0.31 mmHg).Conclusion. Compared to sGAT, dGAT measurements are highly reproducible and less variable.
25
Dahlin, Paul, Marion C. Müller, Sophia Ekengren, Lauren S. McKee, and Vincent Bulone. "The Impact of Steroidal Glycoalkaloids on the Physiology of Phytophthora infestans, the Causative Agent of Potato Late Blight." Molecular Plant-Microbe Interactions® 30, no. 7 (2017): 531–42. http://dx.doi.org/10.1094/mpmi-09-16-0186-r.
Full textAbstract:
Steroidal glycoalkaloids (SGAs) are plant secondary metabolites known to be toxic to animals and humans and that have putative roles in defense against pests. The proposed mechanisms of SGA toxicity are sterol-mediated disruption of membranes and inhibition of cholinesterase activity in neurons. It has been suggested that phytopathogenic microorganisms can overcome SGA toxicity by enzymatic deglycosylation of SGAs. Here, we have explored SGA-mediated toxicity toward the invasive oomycete Phytophthora infestans, the causative agent of the late blight disease in potato and tomato, as well as the potential for SGA deglycosylation by this species. Our growth studies indicate that solanidine, the nonglycosylated precursor of the potato SGAs α-chaconine and α-solanine, has a greater physiological impact than its glycosylated forms. All of these compounds were incorporated into the mycelium, but only solanidine could strongly inhibit the growth of P. infestans in liquid culture. Genes encoding several glycoside hydrolases with potential activity on SGAs were identified in the genome of P. infestans and were shown to be expressed. However, we found no indication that deglycosylation of SGAs takes place. We present additional evidence for apparent host-specific adaptation to potato SGAs and assess all results in terms of future pathogen management strategies.
26
Louis, RE, and MF Radermecker. "Acute bronchial obstruction following inhalation of PAF in asthmatic and normal subjects: comparison with methacholine." European Respiratory Journal 9, no. 7 (1996): 1414–20. https://doi.org/10.1183/13993003/erj.9.7.1414.
Full textAbstract:
Platelet-activating factor (PAF) may play a role in the pathophysiology of asthma but controversies exist about bronchial responsiveness toward this mediator in asthma. We have compared the variations in the specific conductance (sGaw) and forced expiratory volume in one second (FEV1) in 12 asthmatics and 12 normal subjects after inhalation of doubling doses of PAF (15-120 micrograms) and methacholine (18 to at least 144 micrograms). In order to take into account a possible tachyphylaxis, we compared PAF dose-response curves performed on one day with the curves obtained by giving the same doses separately on different days. Repeated inhalations of doubling doses of PAF caused sGaw and FEV1 to plateau after the second dose in each group, whereas methacholine provoked a dose-related decrease in sGaw and FEV1. A dose-dependent decrease in the functional indices was restored when the different doses of PAF were administered on separate days. In both groups, the fall in sGaw after inhalation of 60 micrograms as a single dose was higher than that achieved when this dose was given during a full bronchial challenge. The falls in sGaw and FEV1 after PAF inhalation were significantly higher in the asthmatics than in the normal subjects. The provocative dose of PAF causing a 35% fall in sGaw (PD35,sGaw) PAF was only twofold lower in the asthmatics than in the normal subjects (p < 0.05), while it was 11 fold lower for methacholine (p < 0.001). When the PD35,sGaw values were compared, PAF was found on a molar basis to be 33 fold more potent than methacholine in the normal subjects, but only fivefold more potent in the asthmatics (p < 0.05). The percentage falls in FEV1 (calculated by interpolation) for a 35% fall in sGaw, were greater in asthmatics than in normals both for methacholine (p < 0.05) and PAF (p = 0.09). Our results demonstrate a tachyphylaxis after inhalation of platelet-activating factor in normal subjects and asthmatics, and show that asthmatics develop a greater bronchial obstruction than normal subjects even if methacholine is more sensitive than platelet-activating factor at discriminating between the two groups.
27
Iglesias, Carla, Lu Luo, Javier Martínez, Daniel J. Kelly, Javier Taboada, and Ignacio Pérez. "Obtaining the sGAG distribution profile in articular cartilage color images." Biomedical Engineering / Biomedizinische Technik 64, no. 5 (2019): 591–600. http://dx.doi.org/10.1515/bmt-2018-0055.
Full textAbstract:
Abstract The articular cartilage tissue is an essential component of joints as it reduces the friction between the two bones. Its load-bearing properties depend mostly on proteoglycan distribution, which can be analyzed through the study of the presence of sulfated glycosaminoglycan (sGAG). Currently, sGAG distribution in articular cartilage is not completely known; it is calculated by means of laboratory tests that imply the inherent inaccuracy of a manual procedure. This paper presents an easy-to-use desktop software application for obtaining the sGAG distribution profile in tissue. This app uses color images of stained cartilage tissues taken under a microscope, so researchers at the Trinity Centre for Bioengineering (Dublin, Ireland) can understand the qualitative distribution of sGAG with depth in the studied tissues.
28
Haikal Abdullah, Amirul, Siti Salasiah Mokri, Ahmad Abid Hakimi Md Salleh, and QurratuAini Thaqifah Ithanin. "CLASSIFICATION OF PULMONARY LESIONS USING GAN AND SEMI SUPERVISED GAN." International Journal of Advanced Research 12, no. 10 (2024): 1582–91. http://dx.doi.org/10.21474/ijar01/19789.
Full textAbstract:
Lung cancer is a leading cause of cancer-related deaths, with early detection being important for effective treatment. This study investigates automated lung nodules classification using Generative Adversarial Networks (GANs) and semi-supervised GAN (SGAN), to address data scarcity issues in lung nodule classification. By generating synthetic lung nodule images, SGAN and conventional GAN models are evaluated on image quality, variation, and classification metrics, including accuracy, specificity, sensitivity, and test set loss. Although SGAN produces superior synthetic images, both models achieve comparable classification accuracy of 95%. GAN demonstrates slightly higher specificity and sensitivity. The results show that while SGAN generates enhanced synthetic images, the improvement does not result in better classification due to the grayscale nature of the images and effective feature extraction by the classifier.
29
Chen, Guojie, and Min Lin. "Sample-Based Gradient Edge and Angular Prediction for VVC Lossless Intra-Coding." Applied Sciences 14, no. 4 (2024): 1653. http://dx.doi.org/10.3390/app14041653.
Full textAbstract:
Lossless coding is a compression method in the Versatile Video Coding (VVC) standard, which can compress video without distortion. Lossless coding has great application prospects in fields with high requirements for video quality. Since the current VVC standard is mainly designed for lossy coding, the compression efficiency of VVC lossless coding makes it hard to meet people’s needs. In order to improve the performance of VVC lossless coding, this paper proposes a sample-based intra-gradient edge detection and angular prediction (SGAP) method. SGAP utilizes the characteristics of lossless intra-coding to employ samples adjacent to the current sample as reference samples and performs prediction through sample iteration. SGAP aims to improve the prediction accuracy for edge regions, smooth regions and directional texture regions in images. Experimental results on the VVC Test Model (VTM) 12.3 reveal that SGAP achieves 7.31% bit-rate savings on average in VVC lossless intra-coding, while the encoding time is only increased by 5.4%. Compared with existing advanced sample-based intra-prediction methods, SGAP can provide significantly higher coding performance gain.
30
Martineau, Jérôme, Daniel F. Kalbermatten, and Carlo M. Oranges. "Safety and Efficacy of the Superior Gluteal Artery Perforator (SGAP) Flap in Autologous Breast Reconstruction: Systematic Review and Meta-Analysis." Cancers 14, no. 18 (2022): 4420. http://dx.doi.org/10.3390/cancers14184420.
Full textAbstract:
(1) Background: The superior gluteal artery perforator (SGAP) flap is a prominent technique for autologous breast reconstruction. Unlike other commonly used techniques, current literature on the safety and efficacy of the SGAP flap is heterogenous and limited. The aim of this article was to perform a systematic literature review and meta-analysis of postoperative outcomes and complications associated with SGAP flap autologous breast reconstructions. (2) Methods: A systematic literature search of multiple databases was performed using the PRISMA guidelines. We included articles evaluating SGAP flaps in autologous breast reconstruction. Outcomes and complications were recorded and analyzed. Proportions and their 95% confidence intervals (CIs) were calculated in a random-effects meta-analysis. (3) Results: Fourteen studies meeting inclusion criteria, representing a total of 667 SGAP flaps, were included. The total flap loss rate was 1% (95% CI 0–3%), partial flap loss rate was 1% (95% CI 0–3%), hematoma rate was 3% (95% CI 1–6%), emergent surgical re-exploration rate was 5% (95% CI 2–9%), and overall donor-site complications were 12% (95% CI 4–23%). (4) Conclusions: This systematic review and meta-analysis provide comprehensive knowledge on the efficacy and safety of the SGAP flap in autologous breast reconstruction. It demonstrates its overall safety and low complication rate, validating its important role as an effective option in breast reconstruction.
31
Fabrazzo, Michele, Salvatore Cipolla, Alessio Camerlengo, Francesco Perris, and Francesco Catapano. "Second-Generation Antipsychotics’ Effectiveness and Tolerability: A Review of Real-World Studies in Patients with Schizophrenia and Related Disorders." Journal of Clinical Medicine 11, no. 15 (2022): 4530. http://dx.doi.org/10.3390/jcm11154530.
Full textAbstract:
Despite methodological limitations, real-world studies might support clinicians by broadening the knowledge of antipsychotics’ (APs) effectiveness and tolerability in different clinical scenarios and complement clinical trials. We conducted an extensive literature search in the PubMed database to evaluate the effectiveness and tolerability profiles of second-generation antipsychotics (SGAs) from real-world studies to aid clinicians and researchers in selecting the proper treatment for patients with schizophrenia and related disorders. The present review evidenced that SGAs demonstrated superior effectiveness over first-generation antipsychotics (FGAs) in relapse-free survival and psychiatric hospitalization rate and for treating negative symptoms. Persistence and adherence to therapy were higher in SGAs than FGAs. Most studies concluded that switching to long-acting injectables (LAIs) was significantly associated with a lower treatment failure rate than monotherapy with oral SGAs. Considerable improvements in general functionality, subjective well-being, and total score on global satisfaction tests, besides improved personal and social performance, were reported in some studies on patients treated with LAI SGAs. Clozapine was also associated with the lowest rates of treatment failure and greater effectiveness over the other SGAs, although with more severe side effects. Effectiveness on primary negative symptoms and cognitive deficits was rarely measured in these studies. Based on the data analyzed in the present review, new treatments are needed with better tolerability and improved effectiveness for negative, affective, and cognitive symptoms.
32
Huynh, Nghi, Marc Frappier, Herman Pooda, Amel Mammar, and Régine Laleau. "SGAC: A Multi-Layered Access Control Model with Conflict Resolution Strategy." Computer Journal 62, no. 12 (2019): 1707–33. http://dx.doi.org/10.1093/comjnl/bxz039.
Full textAbstract:
AbstractThis paper presents SGAC (Solution de Gestion Automatisée du Consentement / automated consent management solution), a new healthcare access control model and its support tool, which manages patient wishes regarding access to their electronic health records (EHR). This paper also presents the verification of access control policies for SGAC using two first-order-logic model checkers based on distinct technologies, Alloy and ProB. The development of SGAC has been achieved within the scope of a project with the University of Sherbrooke Hospital (CHUS), and thus has been adapted to take into account regional laws and regulations applicable in Québec and Canada, as they set bounds to patient wishes: for safety reasons, under strictly defined contexts, patient consent can be overriden to protect his/her life (break-the-glass rules). Since patient wishes and those regulations can be in conflict, SGAC provides a mechanism to address this problem based on priority, specificity and modality. In order to protect patient privacy while ensuring effective caregiving in safety-critical situations, we check four types of properties: accessibility, availability, contextuality and rule effectivity. We conducted performance tests comparison: implementation of SGAC versus an implementation of another access control model, XACML, and property verification with Alloy versus ProB. The performance results show that SGAC performs better than XACML and that ProB outperforms Alloy by two order of magnitude thanks to its programmable approach to constraint solving.
33
Kuchenbuch, René, Pranit Nale, Laura Niemann, Oliver Werth, and Jürgen Sauer. "Practical Application of Energy-Related Use Case Methodology and SGAM Framework: A Study of User Perspectives and Challenges." ACM SIGEnergy Energy Informatics Review 4, no. 4 (2024): 23–32. https://doi.org/10.1145/3717413.3717416.
Full textAbstract:
The IEC 62559 Use Case Methodology and the Smart Grid Architecture Model Framework (SGAM) play a crucial role in energy-related national and European research and innovation projects, facilitating a shared understanding among stakeholders in ICT-based Smart Grid solutions. However, their adoption presents challenges due to the complexity and diverse expert backgrounds involved, which can lead to ambiguous IEC 62559 Use Cases and SGAM Models, and consequently, potentially wrong decisions in the implementation by inaccurate descriptions or models. This research identifies the challenges faced by IEC 62559 Use Cases and SGAM Model modelers, as well as their working processes utilizing the toolchain. To achieve this, a survey was conducted among experts experienced in modeling IEC 62559 Use Cases and SGAM Models, followed by qualitative content analysis of the collected data. The findings enhance the usage of the standard/framework and toolchain by improving the understanding of creators' challenges. The results aim to enhance both energy-related and methodological research projects by leveraging modelers' insights into project conditions and processes. This includes ensuring that required information are available on creating, establishing collaborative structures for SGAM modeling, and advancing the maturity of the Use Case Management Repository. The insights support the development of future qualitative SGAM Models and IEC 62559 Use Case descriptions, thereby raising awareness of potential issues.
34
Doane, Michael J., Leona Bessonova, Kathleen Mortimer, et al. "Weight Gain and Treatment Interruptions with Second-Generation Oral Antipsychotics: Analysis of Patients with Schizophrenia or Bipolar I Disorder." CNS Spectrums 26, no. 2 (2021): 160. http://dx.doi.org/10.1017/s1092852920002576.
Full textAbstract:
AbstractAmong patients with schizophrenia (SZ) and bipolar I disorder (BD-I) treated with second-generation antipsychotics (SGAs), clinically-significant weight gain (CSWG) and treatment interruptions (TIs) are challenges that may result in morbidity/mortality.CSWG and TIs were assessed among patients who initiated oral SGAs of moderate-to-high weight gain risk (no exposure to index SGAs/first-generation antipsychotics for =12 months) using medical records/claims (OM1 Data Cloud; January 2013-February 2020). Outcomes included CSWG (=7% increase in baseline weight) and TIs (switches [to SGAs of low weight gain risk/long-acting injectables] or discontinuations [no SGAs for >30 days]). Descriptive analyses included proportions of patients with CSWG and TIs, and median time to these outcomes.Approximately three-quarters of patients were overweight/obese at baseline (SZ: N=8,174; BD-I: N=9,142). Within 3 months of SGA initiation, 12% of all patients experienced CSWG. For patients on treatment with index SGAs for >6 months (SZ: 29%; BD-I: 27%), 28% (SZ) and 30% (BD-I) experienced CSWG during follow-up. Median time to CSWG was 14 weeks. CSWG results were numerically similar among patients with SZ and BD-I.Over 96% of patients had TIs during follow-up (median time of 12 [SZ] and 13 [BD-I] weeks). Among patients with CSWG and subsequent TIs and weight measurements, 74% did not return to baseline weight after interrupting treatment; the remainder returned to baseline weight with median times of 38 (SZ) and 39 (BD-I) weeks. Results suggest that most patients with CSWG do not return to baseline weight after stopping treatment with oral SGAs of moderate-to-high weight gain risk.Funding. Alkermes, Inc.
35
Corbo, M., T. Acciavatti, S. Marini, et al. "First-generation versus second-generation antipsychotic drugs for depression in schizophrenia." European Psychiatry 33, S1 (2016): s245. http://dx.doi.org/10.1016/j.eurpsy.2016.01.620.
Full textAbstract:
IntroductionA certain degree of depressive symptoms is common in schizophrenic patients. The assessment and treatment of depressive symptoms in schizophrenia is clinically challenging.ObjectivesWe conducted a cross-sectional study to investigate the depressive dimension of schizophrenic patients.AimsThe aim was to evaluate the effect of pharmacotherapy on depressive symptomatology.MethodsThirty-four outpatients (18-65 years old) with stable schizophrenia in monotherapy with FGAs or SGAs. We evaluated: depressive symptoms with Calgary Depression Scale for Schizophrenia; positive and negative symptoms (with Positive and Negative Symptom Scale); neurocognition (with Matrics Cognitive Consensus Battery); social cognition (with Facial Emotional Identification Test); social functioning (with Personal and Social Performance Scale and with UCSD Performance-based Skills Assessment). Collected data underwent statistical analyses.ResultsA SGAs therapy was associated with: lower depressive symptoms (mean SGAs group = 4.0; mean FGAs group = 7.86, P < 0.05); lower mean positive symptoms (mean SGAs group = 12.65; mean FGAs group = 17.43, P < 0.05); lower negative symptoms (mean SGAs group = 21.35; mean FGAs group = 29.07, P < 0.05); lower scores on the PANSS-total (mean SGAs group = 71.05; mean FGAs group = 91.86, P < 0.01). After correction for multiple variables, the SGAs group still had significantly lower values towards the FGAs group (P < 0.05).ConclusionsOur study support the notion that switch from a FGA to a SGA could be a relatively simple first-step for the treatment of this condition. Atypical antipsychotics might exercise antidepressant effects with different potential mechanism including: remission of a FGA-induced depression and action on of 5-hydroxytryptamine, dopamine [other than postsynaptic D2], and α1-noradrenergic receptor sites.Disclosure of interestThe authors have not supplied their declaration of competing interest.
36
Trifanenkova, Irina G., Elena V. Petersen, Sergei V. Novikov, and Galina Yu Usanova. "The effect of the sulfated glycosaminoglycans complex on the human corneal epithelial cells proliferation: an <i>in vitro</i> experiment." Aspirantskiy Vestnik Povolzhiya 22, no. 2 (2022): 56–61. http://dx.doi.org/10.55531/2072-2354.2022.22.2.56-61.
Full textAbstract:
Aim to study the proliferative effect of various concentrations of sulfated glycosaminoglycans (sGAG) on the culture of human corneal epithelial cells.
 Material and methods. The study focused on the properties of a mixture of sGAG consisting of chondroitin-4-sulfate, chondroitin-6-sulfates and keratan sulfates obtained by isolation from the transparent unchanged stroma of the cornea of farm animals. The material for the in vitro study was the cells of the anterior epithelium of the human cornea.
 In the experimental group No.1, a mixture of sGAG was added to the culture medium at a concentration of 0.1%, in the experimental group No.2 at a concentration of 0.5%, in the experimental group No.3 at a concentration of 1.0%. In the control group No.1, the medium was replaced without the addition of solutions, cell seeding was carried out similarly to seeding with experimental samples. The negative control group included the holes of the tablet without the addition of medium and solution.
 Results. The highest levels of the cellular index (CI) were obtained in the experimental group No.3 (1.00% of sGAG) and amounted to 2.86 0.11 (the total increase in indicators was 60.67%). In the experimental group No.2 (0.50% sGAG), the cellular index levels were 2.650.24 (the total increase in indicators was 52.29%), which was significantly different from the experimental group No.1 (0.10% sGAG) and the control group No.1, where these indicators were 2.54 0.21 (35.81%) and 2.370.02 (25.39%) respectively.
 Conclusion. The final CI indicators show that solutions of the sGAG mixture at concentrations of 0.5% and 1.0% have a more pronounced proliferative effect on human corneal epithelial cells in vitro from the range of concentrations under study. The results obtained open up the prospects for the use of sGAG in the development of new approaches to the treatment of patients undergoing a chronic drug therapy or patients with concomitant corneal diseases.
37
Granton, David, Myanca Rodrigues, Valeria Raparelli, et al. "Sex and gender-based analysis and diversity metric reporting in acute care trials published in high-impact journals: a systematic review." BMJ Open 14, no. 5 (2024): e081118. http://dx.doi.org/10.1136/bmjopen-2023-081118.
Full textAbstract:
ObjectiveTo characterise sex and gender-based analysis (SGBA) and diversity metric reporting, representation of female/women participants in acute care trials and temporal changes in reporting before and after publication of the 2016 Sex and Gender Equity in Research guideline.DesignSystematic review.Data sourcesWe searched MEDLINE for trials published in five leading medical journals in 2014, 2018 and 2020.Study selectionTrials that enrolled acutely ill adults, compared two or more interventions and reported at least one clinical outcome.Data abstraction and synthesis4 reviewers screened citations and 22 reviewers abstracted data, in duplicate. We compared reporting differences between intensive care unit (ICU) and cardiology trials.ResultsWe included 88 trials (75 (85.2%) ICU and 13 (14.8%) cardiology) (n=111 428; 38 140 (34.2%) females/women). Of 23 (26.1%) trials that reported an SGBA, most used a forest plot (22 (95.7%)), were prespecified (21 (91.3%)) and reported a sex-by-intervention interaction with a significance test (19 (82.6%)). Discordant sex and gender terminology were found between headings and subheadings within baseline characteristics tables (17/32 (53.1%)) and between baseline characteristics tables and SGBA (4/23 (17.4%)). Only 25 acute care trials (28.4%) reported race or ethnicity. Participants were predominantly white (78.8%) and male/men (65.8%). No trial reported gendered-social factors. SGBA reporting and female/women representation did not improve temporally. Compared with ICU trials, cardiology trials reported significantly more SGBA (15/75 (20%) vs 8/13 (61.5%) p=0.005).ConclusionsAcute care trials in leading medical journals infrequently included SGBA, female/women and non-white trial participants, reported race or ethnicity and never reported gender-related factors. Substantial opportunity exists to improve SGBA and diversity metric reporting and recruitment of female/women participants in acute care trials.PROSPERO registration numberCRD42022282565.
38
Bertelli, Marco O., Annamaria Bianco, Micaela Piva Merli, Maria Stella Vescio, Michele Rossi, and Elisabetta F. Buonaguro. "Personal Quality of Life as an Outcome Measure of Antipsychotic Drug Management of Problem Behaviours in Adults with Intellectual Developmental Disorders with or Without Autism Spectrum Disorder." Brain Sciences 15, no. 3 (2025): 316. https://doi.org/10.3390/brainsci15030316.
Full textAbstract:
Background/Objectives: First-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs) are frequently prescribed for the management of problem behaviours (PBs) in people with intellectual developmental disorders (IDDs) with or without autism spectrum disorder (ASD). However, the different effectiveness of these two groups of drugs has not been adequately investigated, especially in terms of person-centred outcomes, such as quality of life (QoL). The aim of the present observational study was to compare the personal QoL of two groups of people with IDDs with and without ASD, attending the same residential facility, but receiving FGAs and SGAs, respectively, for the management of PBs. Methods: Twenty-two people with IDDs (ten with ASD) receiving FGAs and twenty-three (eleven with ASD) receiving SGAs for the management of PBs were consecutively recruited. The participants underwent a complex clinical and instrumental evaluation, including the systematic psychopathological assessment for persons with intellectual and developmental disabilities—general screening (SPAIDD-G), the Wing’s handicaps, behaviours, and skills schedule (HBS), the DOTES, and the BASIQ (QoL Assessment tool battery). Follow-up evaluations were carried out after 6, 12, and 18 months. Results: The use of antipsychotics was withdrawn only in 16 cases, of which only 4 were for significant improvement. Treatment with FGAs was associated with more frequent discontinuation, a higher incidence of side effects, and a trend toward a lower efficacy on PBs than treatment with SGAs. FGAs also improved generic QoL significantly less than SGAs. Conclusions: The present pilot study is the first to compare FGAs and SGAs with respect to the generic QoL in people with IDDs and PBs. SGAs resulted to have a significantly greater positive impact on QoL than FGAs, despite demonstrating similar efficacy in treating PBs.
39
Weng, Saizheng, Bo Wang, Mo Li, et al. "Genome-wide association study of antipsychotic-induced sinus bradycardia in Chinese schizophrenia patients." PLOS ONE 16, no. 4 (2021): e0249997. http://dx.doi.org/10.1371/journal.pone.0249997.
Full textAbstract:
Second-generation antipsychotics (SGAs) play a critical role in current treatment of schizophrenia (SCZ). It has been observed that sinus bradycardia, rare but in certain situations life threatening adverse drug reaction, can be induced by SGAs across different schizophrenia populations. However, the roles of genetic factors in this phenomenon have not been studied yet. In the present study, a genome-wide association study of single nucleotide polymorphisms (SNPs) was performed on Chinese Han SCZ patients to identify susceptibility loci that were associated with sinus bradycardia induced by SGAs. This study applied microarray to obtain genotype profiles of 88 Han Chinese SCZ patients. Our results found that there were no SNPs had genome-wide significant association with sinus bradycardia induced by SGAs. The top GWAS hit located in gene KIAA0247, which mainly regulated by the tumor suppressor P53 and thus plays a role in carcinogenesis based on resent research and it should not be a susceptibility locus to sinus bradycardia induced by SGAs. Using gene-set functional analysis, we tested that if top 500 SNPs mapped genes were relevant to sinus bradycardia. The result of gene prioritization analysis showed CTNNA3 was strongly correlated with sinus bradycardia, hinting it was a susceptibility gene of this ADR. Our study provides a preliminary study of genetic variants associated with sinus bradycardia induced by SGAs in Han Chinese SCZ patients. The discovery of a possible susceptibility gene shed light on further study of this adverse drug reaction in Han Chinese SCZ patients.
40
Amini, Zohreh, Mohammad Hossein Fatemi та Arvi Rauk. "Molecular dynamics studies of a β-sheet blocking peptide with the full-length amyloid beta peptide of Alzheimer’s disease". Canadian Journal of Chemistry 94, № 10 (2016): 833–41. http://dx.doi.org/10.1139/cjc-2016-0267.
Full textAbstract:
The region encompassing residues 13–23 of the amyloid beta peptide (Aβ(13–23)) of Alzheimer’s disease is the self-recognition site that initiates toxic oligomerization and fibrillization. A number of pseudopeptides have been designed to bind to Aβ(13–23) and been computationally shown to do so with high affinity. More interactions are available in full-length Aβ than are available in the shorter peptide. We describe herein a study by molecular dynamics (MD) of nine distinct complexes formed by one such pseudopeptide, SGA1, with full-length beta amyloid, Aβ(1–42). The relative stabilities of the Aβ–SGA1 complexes were estimated by a combination of MD and ab initio methods. The most stable complex, designated AB1, was found to be one in which SGA1 is bound to the self-recognition site of Aβ(1–42) in an antiparallel β-sheet fashion. Another complex, designated AB3, also involved SGA1 binding to the self-recognition region of Aβ(1–42), albeit with lower affinity. In both AB1 and AB3, SGA1 formed antiparallel β-sheets but to opposite edges of Aβ. A complex, AB4, with similar stability to AB3, was found with a parallel β-sheet in the self-recognition site. A fourth complex, AB7, also with similar stability, formed a parallel β-sheet in the hydrophobic central region of Aβ. In all cases, complexation of SGA1 induced extensive β-sheet structure in Aβ(1–42).
41
Park, Sean K., Kyle J. Schank, Abigail Engwall-Gill, and James H. W. Clarkson. "Superior gluteal artery perforator flap salvaged via hyperbaric oxygen therapy." BMJ Case Reports 15, no. 3 (2022): e248411. http://dx.doi.org/10.1136/bcr-2021-248411.
Full textAbstract:
The superior gluteal artery perforator (SGAP) flap can be challenging and in common with all flaps can develop venous and arterial insufficiency. Several prior studies have demonstrated the successful utility of hyperbaric oxygen therapy (HBOT) in the salvage of compromised flaps, mainly with deep inferior epigastric perforator, latissimus dorsi or transverse rectus abdominis myocutaneous flaps. SGAP flaps are autologous alternatives to abdominal-based flaps and provides adequate adipose tissue for breast reconstruction. We report a case of a woman in her 50s who underwent a delayed bilateral breast reconstruction using SGAP free flaps. Postoperatively, venous congestion of her right breast flap was noted for which she was referred for HBOT. An acceptable aesthetic result was achieved following 17 HBOT treatments. This is the first case we can find in the published literature of ischaemic SGAP free flap being salvaged by HBOT.
42
Vescuso, Jackson, Michael Dunn, Cayleigh A. Montaño, et al. "High Pressure Ventilation Injuries from Supraglottic Airway Devices." International Journal of Paramedicine, no. 5 (January 5, 2024): 125–32. http://dx.doi.org/10.56068/nram4387.
Full textAbstract:
Supraglottic airways (SGAs) can be life-saving devices allowing for oxygenation and ventilation in patients who cannot be intubated. However, these devices also have a risk of high-pressure ventilation injuries, including pneumothoraces, pneumomediastinum, and massive subcutaneous air. We present two cases of patients with high-pressure ventilation injuries after the placement of SGAs in the prehospital setting. Clinicians should be aware of the risk of high-pressure ventilation injuries with SGAs, especially in older patients, those with a higher BMI, those with preexisting airway trauma, and those with high-pressure ventilation requirements.
43
Mo, Yoonsun, and Felix K. Yam. "Rational Use of Second-Generation Antipsychotics for the Treatment of ICU Delirium." Journal of Pharmacy Practice 30, no. 1 (2016): 121–29. http://dx.doi.org/10.1177/0897190015585763.
Full textAbstract:
Delirium, described as an acute neuropsychiatric syndrome, occurs commonly in critically ill patients and leads to many negative outcomes including increased mortality and long-term cognitive deficits. Despite the lack of clinical data supporting the use of antipsychotics for the management of intensive care unit (ICU) delirium, pharmacological interventions are often needed to control acutely agitated patients. Given that the most current guidelines do not advocate the use of haloperidol for either the prevention or treatment of ICU delirium due to a lack of evidence, second-generation antipsychotics (SGAs) have been commonly used as alternatives to haloperidol for ICU patients with delirium. Nonetheless, the evidence supporting the use of SGAs to treat ICU delirium remains limited. This review is designed to assess the available clinical evidence and highlights the different neuropharmacological and safety properties of SGAs in order to guide the rational use of SGAs for the treatment of ICU delirium.
44
Young, Jonathan D., Shuangxia Ren, Lujia Chen, and Xinghua Lu. "Revealing the Impact of Genomic Alterations on Cancer Cell Signaling with an Interpretable Deep Learning Model." Cancers 15, no. 15 (2023): 3857. http://dx.doi.org/10.3390/cancers15153857.
Full textAbstract:
Cancer is a disease of aberrant cellular signaling resulting from somatic genomic alterations (SGAs). Heterogeneous SGA events in tumors lead to tumor-specific signaling system aberrations. We interpret the cancer signaling system as a causal graphical model, where SGAs affect signaling proteins, propagate their effects through signal transduction, and ultimately change gene expression. To represent such a system, we developed a deep learning model called redundant-input neural network (RINN) with a transparent redundant-input architecture. Our findings demonstrate that by utilizing SGAs as inputs, the RINN can encode their impact on the signaling system and predict gene expression accurately when measured as the area under ROC curves. Moreover, the RINN can discover the shared functional impact (similar embeddings) of SGAs that perturb a common signaling pathway (e.g., PI3K, Nrf2, and TGF). Furthermore, the RINN exhibits the ability to discover known relationships in cellular signaling systems.
45
Zaussinger, Maximilian, Gabriele Pommer, Katrin Freller, Manfred Schmidt, and Georg M. Huemer. "Bilateral Superior Gluteal Artery Perforator (SGAP) Flap: Modified Concept in Perineal Reconstruction." Journal of Clinical Medicine 13, no. 13 (2024): 3825. http://dx.doi.org/10.3390/jcm13133825.
Full textAbstract:
Background/Objectives: Perineal reconstruction after abdominoperineal excision often requires complex closures and is fraught with wound healing complications. Flap-based approaches introduce non-irradiated vascularized tissue to the area of resection to fill a large soft-tissue defect and dead space, reduce the risk of infection, and facilitate wound healing. Employing perforator flaps with their beneficial donor site properties, the authors have developed a concept of bilateral superior gluteal artery perforator (SGAP) flaps to restore extensive perineal defects. Methods: This retrospective case series was conducted between September 2015 and December 2019. We included three patients who received bilateral SGAP flap reconstruction after oncological resection. One deepithelialized SGAP flap was used for obliteration of dead space, combined with the contralateral SGAP flap for superficial defect reconstruction and wound closure. Results: Within this patient population, two male and one female patient, with a median age of 62 years (range, 52–76 years), were included. Six pedicled SGAP flaps were performed with average flap dimensions of 9 × 20 cm (range 7–9 × 19 × 21). No flap loss or no local recurrence were documented. In one case, partial tip necrosis with prolonged serous drainage was observed, which was managed by surgical debridement. No further complications were detected. Conclusions: The combination of two SGAP flaps provides maximal soft tissue for defect reconstruction and obliteration of dead space, while maintaining a very inconspicuous donor site, even with bilateral harvesting. Given these advantages, the authors recommend this promising approach for successful reconstruction of perineal defects.
46
Pereira, E., F. Coutinho, M. Marinho, and C. Hipólito-Reis. "The role of augmentation treatment with second-generation antipsychotics in major depression disorder–current evidence in the literature." European Psychiatry 33, S1 (2016): S159—S160. http://dx.doi.org/10.1016/j.eurpsy.2016.01.308.
Full textAbstract:
IntroductionMajor depressive disorder (MDD) is a chronic mental illness with a considerable lifetime prevalence in adult men and women. Only a third of MDD patients remit following adequate antidepressant treatment, while most suffer from significant core depressive or residual symptoms during their clinical course. Augmentation treatment with second-generation antipsychotics (SGAs) has been one of the suggested approaches to overcome this shortage of efficacy of antidepressant therapy.ObjectivesTo review the role of SGAs as an augmentation strategy to antidepressant therapy in MDD.MethodsA search of the MEDLINE/Pubmed database was conducted for articles from 2010 to 2015, using the MeSH terms “antypsichotics”, “depression” and “treatment”.ResultsThere is a general consensus in the literature that antidepressant augmentation treatment with SGAs is more effective than placebo in the management of patients with MDD who failed to respond adequately to antidepressant therapy alone. The majority of studies found no significant differences between the different studied drugs (namely, aripiprazole, quetiapine, olanzapine and risperidone). On the other hand, discontinuation rates due to adverse effects are also higher with SGAs versus placebo. However, it remains unclear if augmentation with SGAs is more effective than other therapeutic strategies, such as combination or switching to other antidepressant or augmentation with other psychotropics.ConclusionsThere is strong evidence that SGAs augmentation is an effective and generally safe therapeutic approach to patients with MDD who respond poorly to antidepressants. Nevertheless, more studies are needed to understand the efficacy of this treatment comparing other therapeutic approaches.Disclosure of interestThe authors have not supplied their declaration of competing interest.
47
Abonía Balanta, Valentina, María Fernanda Serrano Guzmán, and Diego Darío Pérez Ruiz. "Soil improvement withsugarcane bagasse ash : technical-economic viabilityfor tertiary roads." Ingenieria Solidaria 20, no. 2 (2024): 1–18. http://dx.doi.org/10.16925/2357-6014.2024.02.06.
Full textAbstract:
Introduction: Economic evaluation of soil subgrade improvement using sugarcane bagasse ash case study: Propal Road - La Cabaña Sugar Mill”, developed at the Pontifical Javeriana University of Cali in 2022. Problem: Tertiary roads in Colombia are essential for mobility in rural areas and for the sugar industry, which generates waste such as sugarcane bagasse ash (SGBA). Objective: To present the results of the economic and technical feasibility study of using sugarcane bagasse ash for soil improvement in tertiary roads. Methodology: Characterization tests of natural soil state and modified Proctor, expansion index, CBR, and unconfined compression for stabilized soils at percentages of 5, 10, 15, and 20% of SGBA are carried out. Results: The mechanical properties of the soil improve with additions of ash between 5% and 15%; however, the utilization of 15% of SGBA is proposed to favor the disposal of a significant volume of this waste. Conclusion: The technical and economic feasibility of using SGBA as a promising solution to improve tertiary roads in Colombia is demonstrated. Originality: Viability of implementing sugarcane bagasse ash on rural roads of sugar mills and agricultural areas with production of this type of waste. Limitations: Similar studies should be carried out for each region to confirm the appropriate percentage for subgrade stabilization using SGBA.
48
Schulze, Sabine, Christin Neuber, Stephanie Möller, Jens Pietzsch, Klaus-Dieter Schaser, and Stefan Rammelt. "Microdialysis Reveals Anti-Inflammatory Effects of Sulfated Glycosaminoglycanes in the Early Phase of Bone Healing." International Journal of Molecular Sciences 24, no. 3 (2023): 2077. http://dx.doi.org/10.3390/ijms24032077.
Full textAbstract:
Although chronic inflammation inhibits bone healing, the healing process is initiated by an inflammatory phase. In a well-tuned sequence of molecular events, pro-inflammatory cytokines are secreted to orchestrate the inflammation response to injury and the recruitment of progenitor cells. These events in turn activate the secretion of anti-inflammatory signaling molecules and attract cells and mediators that antagonize the inflammation and initiate the repair phase. Sulfated glycosaminoglycanes (sGAG) are known to interact with cytokines, chemokines and growth factors and, thus, alter the availability, duration and impact of those mediators on the local molecular level. sGAG-coated polycaprolactone-co-lactide (PCL) scaffolds were inserted into critical-size femur defects in adult male Wistar rats. The femur was stabilized with a plate, and the defect was filled with either sGAG-containing PCL scaffolds or autologous bone (positive control). Wound fluid samples obtained by microdialysis were characterized regarding alterations of cytokine concentrations over the first 24 h after surgery. The analyses revealed the inhibition of the pro-inflammatory cytokines IL-1β and MIP-2 in the sGAG-treated groups compared to the positive control. A simultaneous increase of IL-6 and TNF-α indicated advanced regenerative capacity of sGAG, suggesting their potential to improv bone healing.
49
Saldaña, Shannon N., and Jaclyn Kawsky. "Monitoring and Treatment of Weight Gain in Children and Adolescents Treated with Second Generation Antipsychotics (SGAs)." Mental Health Clinician 1, no. 1 (2011): 3–5. http://dx.doi.org/10.9740/mhc.n74801.
Full textAbstract:
ABSTRACT The use of second generation antipsychotics (SGAs) for the treatment of psychiatric illnesses in children and adolescents is increasing. Adverse effects of SGAs include weight gain, dyslipidemia, insulin resistance, and glucose intolerance that can subsequently progress to diabetes. Data suggest that the metabolic effects of SGAs may be more severe in children and adolescents than in adults. The mechanism of SGA-related weight gain is not fully understood and almost certainly due to a combination of factors. A vital first step to minimize risk and long-term adverse outcomes from SGA treatment is to implement consistent metabolic monitoring.
50
Poojari, Pooja Gopal, Sohil Khan, Sonia Shenoy, et al. "Perspectives of patients and healthcare professionals on metabolic monitoring of adult prescribed second-generation antipsychotics for severe mental illness: A meta-synthesis." PLOS ONE 18, no. 4 (2023): e0283317. http://dx.doi.org/10.1371/journal.pone.0283317.
Full textAbstract:
Objectives We conducted a meta-synthesis of qualitative studies to synthesize the views of psychiatric patients on second-generation antipsychotics (SGAs) and the healthcare providers about the metabolic monitoring of adult-prescribed SGAs. Methods A systematic search was conducted in four databases through SCOPUS, PubMed, EMBASE, and CINAHL to identify qualitative studies of patients’ and healthcare professionals’ perspectives on the metabolic monitoring of SGAs. Initially, titles and abstracts were screened to exclude articles that were not relevant followed by full-text reading. Study quality was assessed by using Critical Appraisal Skills Program (CASP) criteria. Themes were synthesized and presented as per the Interpretive data synthesis process (Evans D, 2002). Results A total of 15 studies met the inclusion criteria and were analyzed in meta-synthesis. Four themes were identified: 1. Barriers to metabolic monitoring; 2. Patient related concerns to metabolic monitoring; 3. Support system by mental health services to promote metabolic monitoring; and 4. Integrating physical health with mental health services. From the participants’ perspectives, barriers to metabolic monitoring were accessibility of services, lack of education and awareness, time/resource constraints, financial hardship, lack of interest on metabolic monitoring, patient capacity and motivation to maintain physical health and role confusion and impact on communication. Education and training on monitoring practices as well as integrated mental health services for metabolic monitoring to promote quality and safe use of SGAs are the most likely approaches to promote adherence to best practices and minimize treatment-related metabolic syndrome in this highly vulnerable cohort. Conclusion This meta-synthesis highlights key barriers from the perspectives of patients and healthcare professionals regarding the metabolic monitoring of SGAs. These barriers and suggested remedial strategies are important to pilot in the clinical setting and to assess the impact of the implementation of such strategies as a component of pharmacovigilance to promote the quality use of SGAs as well as to prevent and/or manage SGAs-induced metabolic syndrome in severe and complex mental health disorders.