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Journal articles on the topic 'SGBC'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Yew, Wen Shan, and John A. Gerlt. "Utilization of l-Ascorbate by Escherichia coli K-12: Assignments of Functions to Products of the yjf-sga and yia-sgb Operons." Journal of Bacteriology 184, no. 1 (2002): 302–6. http://dx.doi.org/10.1128/jb.184.1.302-306.2002.

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ABSTRACT Escherichia coli K-12 can ferment l-ascorbate. The operon encoding catabolic enzymes in the utilization of l-ascorbate (ula) has been identified; this operon of previously unknown function had been designated the yif-sga operon. Three enzymes in the pathway that produce d-xylulose 5-phosphate have been functionally characterized: 3-keto-l-gulonate 6-phosphate decarboxylase (UlaD), l-xylulose 5-phosphate 3-epimerase (UlaE), and l-ribulose 5-phosphate 4-epimerase (UlaF). Several products of the yia-sgb operon were also functionally characterized, although the substrate and physiological

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Makkar, Jeetinder Kaur. "Effects of Stellate Ganglion Block on Breast Cancer-Related Lymphedema: Comparison of Various Injectates." Pain Physician 18;1, no. 1;1 (2015): 93–99. http://dx.doi.org/10.36076/ppj/2015.18.93.

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Background: Stellate ganglion block (SGB) has been reported to be effective in the treatment of breast cancer-related lymphedema (BCRL). Objective: To determine the effects of SGB in BCRL patients and the efficacy of corticosteroids in SGB. Study Design: A double-blinded, randomized, controlled trial. Setting: A single academic hospital, outpatient setting. Methods: In total, 32 patients with BCRL were recruited. Patients were divided randomly into 3 groups (Group A: 0.5% bupivacaine 5 mL, n = 12; Group B: 0.5% bupivacaine 4.5 mL + 20 mg of triamcinolone 0.5 mL, n = 10; and Group C: 0.5% bupiv

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Lumadi, Rudzani Israel. "Critical path to a sustainable future of managing no-fee secondary schools in the Limpopo Province." South African Journal of Education 40, no. 4 (2020): 1–7. http://dx.doi.org/10.15700//saje.v40n4a2044.

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The disparity in the socio-economic status of South Africa has forced the government to adopt a funding policy for public secondary schools. The policy is based on funding schools considered to be poor because they are in poverty-stricken communities. Most of these schools lack infrastructure, and physical and financial resources to be run successfully, while the former Model C schools have adequate resources. In this article I advocate for equitable funding for all learners, and the role played by the school governing body (SGB) in the management of funds is also identified. Semi-structured i

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Dibete, Kgabo Johannes, and Onoriode Collins Potokri. "Policy compliance of SGB members on their financial management roles in selected no-fee schools in Limpopo province of South Africa." International Journal of Educational Management 32, no. 5 (2018): 799–812. http://dx.doi.org/10.1108/ijem-03-2017-0058.

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Purpose The purpose of this paper is to investigate the perceptions of school governing bodies (SGBs) members’ role in financial management in no-fee schools so as to understand their compliance with policy frameworks when managing school finances. No-fee schools are schools in which the learners cannot be levied fees because of the poor socio-economic background of their parents, and are located in Quintiles 1-3 according to National Norms and Standards for School Funding Policy. Design/methodology/approach A qualitative research design/approach within the interpretive paradigm was adopted fo

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Ku, C. P. Roger. "Dynamic Characteristics of Hard Disk Drive Spindle Motors—Comparison Between Ball Bearings and Hydrodynamic Bearings." Journal of Tribology 118, no. 2 (1996): 402–6. http://dx.doi.org/10.1115/1.2831316.

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Recently, many computer hard disk drive companies and spindle motor manufacturers have been looking for a substitute for ball bearings to continue making dramatic progress in increasing the capacity of data storage systems. In this paper, the frequency-forced responses of hard disk drive spindle motors supported by both ball bearings and liquid-lubricated spiral groove hearings (SGBs) were studied experimentally. It is found that both shaft rigidity and disk flexibility have great effects on the natural frequency of the spindle motor conical (rocking) mode. The high damping capacity of the SGB

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Padhi, Ellora, Subhasish Dey, Venkappayya R. Desai, Nadia Penna, and Roberto Gaudio. "Water-Worked Gravel Bed: State-of-the-Art Review." Water 11, no. 4 (2019): 694. http://dx.doi.org/10.3390/w11040694.

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In a natural gravel-bed stream, the bed that has an organized roughness structure created by the streamflow is called the water-worked gravel bed (WGB). Such a bed is entirely different from that created in a laboratory by depositing and spreading gravels in the experimental flume, called the screeded gravel bed (SGB). In this paper, a review on the state-of-the-art research on WGBs is presented, highlighting the role of water-work in determining the bed topographical structures and the turbulence characteristics in the flow. In doing so, various methods used to analyze the bed topographical s

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Setlhodi, Itumeleng Innocentia. "Collaboration practices between the two tiers of school leadership in eradicating underperformance." South African Journal of Education, no. 40(3) (August 31, 2020): 1–11. http://dx.doi.org/10.15700/saje.v40n3a1796.

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Collaboration between the school governing body (SGB) and the school management team (SMT) in underperforming schools remains the crest for successful action taken to turn around performance as envisaged in the South African Schools Act 84 of 1996 (Republic of South Africa, 1996). Their interaction is crucial in advancing the course of performance improvement. In the study reported on here a qualitative method and an interpretivist approach was used to explore how shared leadership collaboration practices between the SGB and SMT can improve performance. A case of 3 purposefully sampled underpe

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Wendel, Christopher, Ricardo Scheibe, Sören Wagner, et al. "Decrease of blood flow velocity in the middle cerebral artery after stellate ganglion block following aneurysmal subarachnoid hemorrhage: a potential vasospasm treatment?" Journal of Neurosurgery 133, no. 3 (2020): 773–79. http://dx.doi.org/10.3171/2019.5.jns182890.

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OBJECTIVECerebral vasospasm (CV) is a delayed, sustained contraction of the cerebral arteries that tends to occur 3–14 days after aneurysmal subarachnoid hemorrhage (aSAH) from a ruptured aneurysm. Vasospasm potentially leads to delayed cerebral ischemia, and despite medical treatment, 1 of 3 patients suffer a persistent neurological deficit. Bedside transcranial Doppler (TCD) ultrasonography is used to indirectly detect CV through recognition of an increase in cerebral blood flow velocity (CBFV). The present study aimed to use TCD ultrasonography to monitor how CBFV changes on both the ipsi-

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Seo, Kwan Sik. "Comparison Between the Effectiveness of Complex Decongestive Therapy and Stellate Ganglion Block in Patients with Breast Cancer-Related Lymphedema: A Randomized Controlled Study." Pain Physician 3, no. 22;3 (2018): 255–63. http://dx.doi.org/10.36076/ppj/2019.22.255.

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Background: Breast cancer-related lymphedema (BCRL) of the upper extremities often follows breast cancer treatment. Although complex decongestive therapy (CDT) is currently the standard treatment for BCRL, stellate ganglion block (SGB) has also been reported to be effective. Objectives: This study aimed to determine the effectiveness of SGB in the treatment of BCRL, and to assess the impact of the treatment on the quality of life (QoL) compared to CDT. Study Design: A randomized controlled trial. Setting: A single academic hospital, outpatient setting. Methods: A total of 38 patients with BCRL

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Aina, Adebunmi Yetunde, and Keshni Bipath. "School financial management: Insights for decision making in public primary schools." South African Journal of Education 40, no. 4 (2020): 1–9. http://dx.doi.org/10.15700/saje.v40n4a1756.

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To realise the ideal of quality inclusive education, proper financial management is vital. Existing literature indicates that the mismanagement of school funds is largely due to principals and the school governing bodies (SGB) in many schools not having good working relationships with stakeholders and lacking the necessary financial skills, more specifically in schools in townships and rural areas. The study we report on in this article investigated the financial management of public primary schools situated in urban areas by adopting a qualitative research approach and employing a multiple ca

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. "Reactie SGRC." Tijdschrift voor Bedrijfs- en Verzekeringsgeneeskunde 14, no. 10 (2006): 551. http://dx.doi.org/10.1007/bf03074487.

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Mathebula, Rifumuni Nancy, Tawanda Runhare, and Nylon Marishane. "A Critique of the Democratic Functionality of the School Disciplinary Committee Structures within a South African Rural Setting." Journal of Educational and Social Research 11, no. 1 (2021): 170. http://dx.doi.org/10.36941/jesr-2021-0017.

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The South Africans Schools Act mandates institutional policy duty bearers such as the school governing bodies (SGBs) and school disciplinary committees (SDCs) through which education stakeholders such as school principals, teachers, parents and learners to democratically formulate and implement school policies. The effectiveness of these bodies in carrying out their responsibilities in most cases is left to speculation. Based on a case study of high schools in a rural district setting in South Africa, this paper reports on the extent to which SDCs are democratically constituted and function in

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Li, Kai, Jian-lin Wu, Baifu Qin, et al. "ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer." Cell Research 30, no. 2 (2019): 163–78. http://dx.doi.org/10.1038/s41422-019-0257-1.

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AbstractThe Serine–Glycine–One-Carbon (SGOC) pathway is pivotal in multiple anabolic processes. Expression levels of SGOC genes are deregulated under tumorigenic conditions, suggesting participation of oncogenes in deregulating the SGOC biosynthetic pathway. However, the underlying mechanism remains elusive. Here, we identified that Interleukin enhancer-binding factor 3 (ILF3) is overexpressed in primary CRC patient specimens and correlates with poor prognosis. ILF3 is critical in regulating the SGOC pathway by directly regulating the mRNA stability of SGOC genes, thereby increasing SGOC genes

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Martin, Ana. "Intersectionality: Explaining SGBV Interlinked with Terrorism and Other International Crimes." Journal of Human Trafficking, Enslavement and Conflict-Related Sexual Violence 1, no. 2 (2020): 135–61. http://dx.doi.org/10.7590/266644720x16062928261028.

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Sexual and gender-based violence (SGBV) is often intertwined with and nested within other violations of international criminal law (ICL) as part of a broader attack against a group. However, ICL is not giving enough visibility to this nexus of crimes rooted in the intersection of identities and discrimination that underpins SGBV during conflict. Intersectionality is a concept originated in feminism and progressively recognized by international human rights law (IHRL). It posits that SGBV is caused by gender 'inextricably linked' with other identities and factors that result in compounded discr

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Hatano, Tamaki. "Survey of violence against women at a refugee settlement in Uganda." Impact 2021, no. 7 (2021): 24–25. http://dx.doi.org/10.21820/23987073.2021.7.24.

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Sexual and gender-based violence (SGBV) can have long-term repercussions on the mental and physical health of survivors. The threat of SGBV increases for women and girls in times of crisis and is on the rise in humanitarian emergencies. For example, women in refugee camps are at risk of SGBV. Associate Professor Tamaki Hatano is working to promote awareness of this situation and help establish a future where SGBV is eradicated. In her work, she conducts interviews with female refugees in order to hear their stories and learn of their experiences. At present, Hatano is studying the Kiryandongo

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van der Meer, R., R. J. Vonk, and F. Kuipers. "Cholestasis and the interactions of sulfated glyco- and taurolithocholate with calcium." American Journal of Physiology-Gastrointestinal and Liver Physiology 254, no. 5 (1988): G644—G649. http://dx.doi.org/10.1152/ajpgi.1988.254.5.g644.

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To elucidate possible mechanisms of the differential cholestatic effect of sulfated glyco- and taurolithocholate (SGLC and STLC) the interactions of these bile acids with calcium were studied both in vitro and in vivo. In vitro, SGLC was readily precipitated by Ca in physiological concentrations (less than 5 mM). It appeared that only micelles of SGLC were precipitated and that both the sulfate and the carboxylate anionic groups participated in Ca binding. Conjugation with taurine almost completely prevented this Ca-dependent precipitation. Intravenous infusion of SGLC (12 mumol/h) in unanesth

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17

Lee, Sang Won, and Jason Freeman. "Real-Time Music Notation in Mixed Laptop–Acoustic Ensembles." Computer Music Journal 37, no. 4 (2013): 24–36. http://dx.doi.org/10.1162/comj_a_00202.

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SGLC is a recent set of extensions to LOLC, a text-based environment for collaborative improvisation for laptop ensembles. SGLC integrates acoustic musicians into the LOLC environment: Laptop musicians author short commands to generate real-time notation, and acoustic musicians sight-read it in performance. We describe the background and motivations of the project, outline the design of LOLC and SGLC, explain the use of SGLC in a musical composition by one of the authors, and evaluate the impact of real-time notation on a concert performance with the environment.

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Mannhold, R. "SGB-1534." Drugs of the Future 10, no. 12 (1985): 993. http://dx.doi.org/10.1358/dof.1985.010.12.75168.

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Moreno Arboleda, Francisco Javier, Juan Esteban Quintero Rendón, and Robinson Rueda Vásquez. "Una comparación de rendimiento entre Oracle y MongoDB." Ciencia e Ingeniería Neogranadina 26, no. 1 (2016): 109. http://dx.doi.org/10.18359/rcin.1669.

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<p>La creciente y enorme cantidad de datos, del orden de exabytes, generados por las aplicaciones empresariales actuales han originado conjuntos masivos de estos. Los sistemas de gestión de bases de datos (SGBD) NoSQL han surgido como una alternativa a los SGBD relacionales para la gestión de estos conjuntos. Entre los principales SGBD NoSQL está MongoDB. En este artículo se compara el rendimiento entre MongoDB y Oracle (uno de los principales SGBD que soporta bases de datos relacionales). La comparación se basa en las operaciones de inserción, consulta, actualización y borrado (CRUD, po

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Annamalai, Padmanaban, and A. L. N. Rao. "Packaging of Brome Mosaic Virus Subgenomic RNA Is Functionally Coupled to Replication-Dependent Transcription and Translation of Coat Protein." Journal of Virology 80, no. 20 (2006): 10096–108. http://dx.doi.org/10.1128/jvi.01186-06.

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ABSTRACT In Brome mosaic virus (BMV), genomic RNA1 (gB1) and RNA2 (gB2), encoding the replication factors, are packaged into two separate virions, whereas genomic RNA3 (gB3) and its subgenomic coat protein (CP) mRNA (sgB4) are copackaged into a third virion. In vitro assembly assays performed between a series of deletion variants of sgB4 and wild-type (wt) CP subunits demonstrated that packaging of sgB4 is independent of sequences encoding the CP open reading frame. To confirm these observations in vivo and to unravel the mechanism of sgB4 copackaging, an Agrobacterium-mediated transient in vi

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SHEN, YANBIN, J. H. M. ANDERLUH, and J. A. M. VAN DER WEIDE. "ALGORITHMIC COUNTERPARTY CREDIT EXPOSURE FOR MULTI-ASSET BERMUDAN OPTIONS." International Journal of Theoretical and Applied Finance 18, no. 01 (2015): 1550001. http://dx.doi.org/10.1142/s0219024915500016.

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For an efficient computation of the counterparty credit exposure profiles of the multi-asset options, a simulation-based method, named the Stochastic Grid Bundling Method (SGBM), is applied. The method is based on a 'regression later' technique used for the conditional expectation approximation and a bundling (or 'binning') technique used for state space partitioning. In the case of high-dimensional underlying asset processes, by using the bundling technique, the accuracy of exposure profiles is improved significantly, and the computation speed is reasonably fast. A detailed analysis for the b

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Buys, Melanie, Pierre du Plessis, and Raj Mestry. "The resourcefulness of school governing bodies in fundraising: Implications for the provision of quality education." South African Journal of Education 40, no. 4 (2020): 1–9. http://dx.doi.org/10.15700/saje.v40n4a2042.

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With the promulgation of the South African Schools Act of 1996, public education in South Africa was decentralised and communities were made responsible for school governance. This placed the responsibility on school governing bodies (SGBs) to take all measures within their means to supplement state funding for the acquisition of adequate human and physical resources. In this article we explore various fundraising initiatives that will increase the coffers of public schools. Funds provided by donors and sponsors should allow SGBs the discretionary powers to appropriate funds that will promote

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Kamau, Evelyn W. "Domestic Adjudication of Sexual and Gender-based Violence in Armed Conflict: Considerations for Prosecutors and Judges." African Journal of Legal Studies 4, no. 1 (2011): 85–122. http://dx.doi.org/10.1163/170873811x567961.

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AbstractThe increased domestication of international core crimes like genocide, crimes against humanity and war crimes has placed national prosecutors and judges on unfamiliar ground. Specifically, though very welcome, the recognition of acts of sexual and gender-based violence (SGBV) as constituting core international crimes poses a further challenge. The circumstances surrounding the commission of SGBV as international core crimes, coupled with their unique elements and manner of proof, makes their domestic prosecution seem that much more difficult. An understanding of how acts of SGBV const

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Jeswani, Sunil, Miriam Nuño, Vanessa Folkerts, Debraj Mukherjee, Keith L. Black, and Chirag G. Patil. "Comparison of Survival Between Cerebellar and Supratentorial Glioblastoma Patients." Neurosurgery 73, no. 2 (2013): 240–46. http://dx.doi.org/10.1227/01.neu.0000430288.85680.37.

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Abstract BACKGROUND: Cerebellar glioblastoma multiforme (cGBM) is rare, and although there is a general belief that these tumors have a worse prognosis than supratentorial GBM (sGBM), few studies have been published to support this belief. OBJECTIVE: To investigate the effect of cerebellar location on survival through a case-control design comparing overall survival time of cGBM and sGBM patients. METHODS: The Surveillance, Epidemiology, and End Results (SEER) registry was used to identify 132 patients with cGBM (1973-2008). Each cGBM patient was matched with an sGBM patient from among 20 848

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Nach, M. "Hawking’s radiation of sine–Gordon black holes in two dimensions." International Journal of Modern Physics A 34, no. 16 (2019): 1950086. http://dx.doi.org/10.1142/s0217751x19500866.

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In the framework of the integrable model of the sine–Gordon equation, we describe a recent method to recover the Hawking temperature from the sine–Gordon black hole (sGBH). We present the SGBH metric, its event horizon and give the Hawking temperature of sine–Gordon black hole. We use the complex path analysis method to examine the Hawking radiation and give the possibility of estimating the evaporation time of the SGBH.

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Bastiaanssen, Marjolein, Frank Moret, and Joost van der Gulden. "De SGBO: 60 jaar jong!" TBV – Tijdschrift voor Bedrijfs- en Verzekeringsgeneeskunde 28, no. 8 (2020): 50. http://dx.doi.org/10.1007/s12498-020-1258-1.

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Amene, C. S., L. A. Yeh-Nayre, and J. R. Crawford. "Secondary Glioblastoma Multiforme in a Child with Disseminated Juvenile Pilocytic Astrocytoma." Case Reports in Oncological Medicine 2012 (2012): 1–4. http://dx.doi.org/10.1155/2012/290905.

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Secondary glioblastoma multiforme (sGBM) can occur after a long latency period following radiation treatment of various diseases including brain tumors, leukemia, and more benign disorders like tinea capitis. Outcomes of radiation-induced sGBM remain poor in both children and adults. We report a case of a 16-year-old girl with a history of disseminated juvenile pilocytic astrocytoma treated with chemotherapy and craniospinal radiation 9 years prior who developed sGBM in the absence of a tumor predisposition syndrome. She presented with a several-week history of headaches and no acute findings

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Chauhan, Swati, Filip Jelen, Iraida Sharina, and Emil Martin. "The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase." Biochemical Journal 446, no. 3 (2012): 445–53. http://dx.doi.org/10.1042/bj20111882.

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sGC (soluble guanylate cyclase) is the main mediator of NO signalling. Biochemical and physiological studies suggest that, besides NO, in vivo regulation of sGC involves direct interaction with other proteins. Using yeast two-hybrid screening, we identified that the multidomain LGN (Leu-Gly-Asn repeat-enriched protein) interacts with both α1 and β1 sGC subunits. LGN and sGC co-localized in the cell cytoplasm, and the LGN–sGC complex was co-immunoprecipitated from cells expressing both proteins and from native tissues. Their interaction requires the N-terminal tetratricopeptide repeats of LGN,

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Huynh, Nghi, Marc Frappier, Herman Pooda, Amel Mammar, and Régine Laleau. "SGAC: A Multi-Layered Access Control Model with Conflict Resolution Strategy." Computer Journal 62, no. 12 (2019): 1707–33. http://dx.doi.org/10.1093/comjnl/bxz039.

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AbstractThis paper presents SGAC (Solution de Gestion Automatisée du Consentement / automated consent management solution), a new healthcare access control model and its support tool, which manages patient wishes regarding access to their electronic health records (EHR). This paper also presents the verification of access control policies for SGAC using two first-order-logic model checkers based on distinct technologies, Alloy and ProB. The development of SGAC has been achieved within the scope of a project with the University of Sherbrooke Hospital (CHUS), and thus has been adapted to take in

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MA Farag, Randa Mohamed, Dujana AlAyobi, Khalid A Alsaleh, Hye-Joo Kwon, Afaf EL-Ansary, and Emad Anwar Dawoud. "Influence of Glypican-3 as Anewly Diagnostic Biomarker in Earlydetection of Hepatocellular Carcinoma among Saudi Patients." Biomedical and Pharmacology Journal 11, no. 4 (2018): 1789–96. http://dx.doi.org/10.13005/bpj/1550.

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In Saudi Arabia AFP considered the main serum marker for diagnostic Hepatocellular carcinoma (HCC), due to the continuous detection of HCC in Saudi Arabia, using new biomarkers for early surveillance are essential to control in prevalence of HCC. The present study depend on compare the significant between serum and mRNA Glypican-3 (GPC-3) as newly identified diagnostic and prognostic biomarkers for HCC between study cases. And combined sensitivity of AFP and GPC-3. Three hundred study cases, divided into: 250 blood samples were 145 samples from HCC , 105 samples from chronic liver cirrhosis (C

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Kuipers, F., M. J. Hardonk, R. J. Vonk, and R. van der Meer. "Bile secretion of sulfated glycolithocholic acid is required for its cholestatic action in rats." American Journal of Physiology-Gastrointestinal and Liver Physiology 262, no. 2 (1992): G267—G273. http://dx.doi.org/10.1152/ajpgi.1992.262.2.g267.

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To test our hypothesis that the cholestatic action of sulfated glycolithocholic acid (SGLC) in the rat is related to its interaction with calcium in the biliary tree [R. van der Meer, R. J. Vonk, and F. Kuipers. Am. J. Physiol. 254 (Gastrointest. Liver Physiol. 17): G644-G649, 1988], we have now compared its effects on bile formation in control Wistar rats and mutant Groningen Yellow (GY) Wistar rats. Intravenous injection of 0.6 mumol/100 g body wt of [14C]SGLC in unanesthetized rats with permanent biliary drainage did not induce cholestasis in either of the strains; however, its biliary secr

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M, Parimala, and Udhayakumar Ramalingam. "SG_C-Projective, Injective and Flat modules." Journal of the Indonesian Mathematical Society 25, no. 2 (2019): 108–20. http://dx.doi.org/10.22342/jims.25.2.754.108-120.

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In this paper we introduce the concepts of $SG_C$-projective, injective and flat modules, where $C$ is a semidualizing module and we discuss some connections among $SG_C$-projective, injective and flat modules.

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Reischer, Theresa, Franco Laccone, Gregor J. Kasprian, and Gülen Yerlikaya-Schatten. "Simpson-Golabi-Behmel-Syndrome in Dichorionic-Diamniotic Twin Pregnancy." Clinics and Practice 11, no. 1 (2021): 75–80. http://dx.doi.org/10.3390/clinpract11010012.

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Simpson-Golabi-Behmel syndrome (SGBS) is a rare x-linked overgrowth syndrome with distinct clinical features, which is difficult to diagnose prenatally. We report the diagnosis of SGBS in dichorionic-diamniotic twin pregnancies in the first trimester by ultrasound and genetic testing. The affected fetus developed polyhydramnios and the cervical length of the mother decreased significantly. To save the unaffected twin, a selective feticide of the affected fetus was performed. Finally, the patient underwent preterm caesarean section due to premature rupture of membranes in the dead twin, and als

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Heckler, Erin J., Pierre-Antoine Crassous, Padmamalini Baskaran, and Annie Beuve. "Protein disulfide-isomerase interacts with soluble guanylyl cyclase via a redox-based mechanism and modulates its activity." Biochemical Journal 452, no. 1 (2013): 161–69. http://dx.doi.org/10.1042/bj20130298.

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NO binds to the receptor sGC (soluble guanylyl cyclase), stimulating cGMP production. The NO–sGC–cGMP pathway is a key component in the cardiovascular system. Discrepancies in sGC activation and deactivation in vitro compared with in vivo have led to a search for endogenous factors that regulate sGC or assist in cellular localization. In our previous work, which identified Hsp (heat-shock protein) 70 as a modulator of sGC, we determined that PDI (protein disulfide-isomerase) bound to an sGC-affinity matrix. In the present study, we establish and characterize this interaction. Incubation of pur

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De Paepe, Monique E., Lawrence Young, Julie R. Jones, and Umadevi Tantravahi. "Ovotesticular Disorder of Sex Development (Ovotestis) in Simpson–Golabi–Behmel Syndrome: Expansion of the Clinical Spectrum." Pediatric and Developmental Pathology 22, no. 1 (2018): 70–74. http://dx.doi.org/10.1177/1093526618770327.

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Simpson–Golabi–Behmel syndrome type I (SGBS, OMIM312870), caused by defects of the GPC3 and GPC4 genes on chromosome Xq26, is an X-linked recessive macrosomia/multiple congenital anomaly disorder characterized by somatic overgrowth, coarse facial features, variable congenital anomalies, increased tumor risk, and mild-to-moderate neurodevelopmental anomalies. We report the postmortem findings in 3 second-trimester male siblings with SGBS who displayed ambiguous genitalia (in all 3) and gonadal dysgenesis (ovotestis) (in 1), thus expanding the SGBS spectrum to include these disorders of sex deve

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Sakuma, Shiho, Eiko Otake, Kan Torii, et al. "Photodynamic therapy with glycoconjugated chlorin photosensitizer." Journal of Porphyrins and Phthalocyanines 17, no. 05 (2013): 331–42. http://dx.doi.org/10.1142/s1088424613500065.

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Photodynamic therapy (PDT) effectively induces tumor cell apoptosis, but the tumor selectivity and photosensitivity of common photosensitizers, such as aspartyl chlorin (NPe6), are not sufficient. Cancer cells phagocytose glucose 3 to 20 times more efficiently than normal cells; therefore, we examined whether glycoconjugation improves photosensitizer tumor-localizability. HaCaT cells were incubated with H2TFPC (unconjugated chlorin), H2TFPC-SGlc (glycoconjugated chlorin), or NPe6, followed by irradiation with 633 nm LED light (16 J.cm-2). PDT with 1 μM H2TFPC-SGlc for 24 h induced significantl

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Bashyal, Santosh, Jo-Eun Seo, Taekwang Keum, Gyubin Noh, Shrawani Lamichhane, and Sangkil Lee. "Development, Characterization, and Ex Vivo Assessment of Elastic Liposomes for Enhancing the Buccal Delivery of Insulin." Pharmaceutics 13, no. 4 (2021): 565. http://dx.doi.org/10.3390/pharmaceutics13040565.

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Buccal drug delivery is a suitable alternative to invasive routes of drug administration. The buccal administration of insulin for the management of diabetes has received substantial attention worldwide. The main aim of this study was to develop and characterize elastic liposomes and assess their permeability across porcine buccal tissues. Sodium-cholate-incorporated elastic liposomes (SC-EL) and sodium-glycodeoxycholate-incorporated elastic liposomes (SGDC-EL) were prepared using the thin-film hydration method. The prepared liposomes were characterized and their ex vivo permeability attribute

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Martin, Emil, Eva Golunski, Susan T. Laing, Anthony L. Estrera, and Iraida G. Sharina. "Alternative splicing impairs soluble guanylyl cyclase function in aortic aneurysm." American Journal of Physiology-Heart and Circulatory Physiology 307, no. 11 (2014): H1565—H1575. http://dx.doi.org/10.1152/ajpheart.00222.2014.

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Nitric oxide (NO) receptor soluble guanylyl cyclase (sGC) is a key regulator of several important vascular functions and is important for maintaining cardiovascular homeostasis and vascular plasticity. Diminished sGC expression and function contributes to pathogenesis of several cardiovascular diseases. However, the processes that control sGC expression in vascular tissue remain poorly understood. Previous work in animal and cell models revealed the complexity of alternative splicing of sGC genes and demonstrated its importance in modulation of sGC function. The aim of this study was to examin

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Guo, Hai, Jinghua Yin, Jingying Zhao, Lei Yao, Xu Xia, and Hao Luo. "An Ensemble Learning for Predicting Breakdown Field Strength of Polyimide Nanocomposite Films." Journal of Nanomaterials 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/950943.

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Using the method of Stochastic Gradient Boosting, ten SMO-SVR are constructed into a strong prediction model (SGBS model) that is efficient in predicting the breakdown field strength. Adopting the method of in situ polymerization, thirty-two samples of nanocomposite films with different percentage compositions, components, and thicknesses are prepared. Then, the breakdown field strength is tested by using voltage test equipment. From the test results, the correlation coefficient (CC), the mean absolute error (MAE), the root mean squared error (RMSE), the relative absolute error (RAE), and the

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Liu, Feng, Jian De Li, Shu Qing Qi, Yang Jiao, and Jin Liang Wu. "Advanced Materials Used in SGCC ECCS Flyaway." Advanced Materials Research 422 (December 2011): 490–96. http://dx.doi.org/10.4028/www.scientific.net/amr.422.490.

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This article introduces some advanced materials used in SGCC ECCS (emergency command and communication system of state grid), and some materials newly used in this system. It also gives some indication of advanced materials development in SGCC ECCS.

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Davies, Sara E., and Jacqui True. "Connecting the Dots: Pre-existing Patterns of Gender Inequality and the Likelihood of Widespread and Systematic Sexual Violence." Global Responsibility to Protect 9, no. 1 (2017): 65–85. http://dx.doi.org/10.1163/1875984x-00901005.

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In this article we explore the relationship between pre-existing patterns of gender inequality and the occurrence of widespread and systematic sexual and gender based violence (sgbv). We ask three questions: What do we know about the status of gender inequality in high-risk situations prior to the outbreak of atrocities (which include sgbv)? What can be done to understand the relationship between systemic gender inequality and the use of sexual violence in the particular high-risk situations? And what long-term approaches are necessary to prevent sgbv?

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Zhang, Guoying, Binggang Xiang, Radek C. Skoda, Susan S. Smyth, Xiaoping Du, and Zhenyu Li. "Biphasic Roles for the Soluble Guanylyl Cyclase (sGC) In Platelet Activation In Mice." Blood 116, no. 21 (2010): 486. http://dx.doi.org/10.1182/blood.v116.21.486.486.

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Abstract Abstract 486 The role of intracellular secondary messenger cGMP in platelet activation has been controversial, with both stimulatory and inhibitory roles reported. The platelet cGMP is believed to be predominantly synthesized by soluble guanylyl cyclase (sGC), which is activated by nitric oxide (NO). To specifically determine the role of sGC-dependent cGMP synthesis in platelet function and in vivo thrombosis and hemostasis, we produced mice harboring a “floxed” sGC beta1 allele. In the “floxed” sGC beta1 mice (sGC beta1fl/fl), the exons 7 and 8 of sGC beta1 gene and an inserted Neo c

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Moreno, Francisco Javier, Nataly Castrillón Charari, and Camilo Taborda Zuluaga. "Procesamiento en paralelo y distribuido en dos SGBDS: un caso de estudio." Revista Tecnura 21, no. 52 (2017): 111. http://dx.doi.org/10.14483/10.14483/udistrital.jour.tecnura.2017.2.a09.

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Contexto: Una de las estrategias para la gestión de grandes volúmenes de datos es la computación distribuida y en paralelo. Entre las herramientas que permiten aplicar estas características se encuentran algunos sistemas de gestión de bases de datos (SGBD), como Oracle, SQL Sever y DB2.Método: En este artículo se presenta un caso de estudio donde se evalúa el rendimiento de una consulta SQL en dos de estos SGBD. La evaluación se hace mediante diversas formas de distribución de los datos en una red computadores y con diferentes grados de paralelismo.Resultados: Aunque son necesarias pruebas más

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Takata, Masao, Galina Filippov, Heling Liu, et al. "Cytokines decrease sGC in pulmonary artery smooth muscle cells via NO-dependent and NO-independent mechanisms." American Journal of Physiology-Lung Cellular and Molecular Physiology 280, no. 2 (2001): L272—L278. http://dx.doi.org/10.1152/ajplung.2001.280.2.l272.

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Exposure of rat pulmonary artery smooth muscle cells (rPASMC) to cytokines leads to nitric oxide (NO) production by NO synthase 2 (NOS2). NO stimulates cGMP synthesis by soluble guanylate cyclase (sGC), a heterodimer composed of α1- and β1-subunits. Prolonged exposure of rPASMC to NO decreases sGC subunit mRNA and protein levels. The objective of this study was to determine whether levels of NO produced endogenously by NOS2 are sufficient to decrease sGC expression in rPASMC. Interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) increased NOS2 mRNA levels and decreased sGC subunit mRNA le

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Zhang, Guoying, Binggang Xiang, Anping Dong, et al. "Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation." Blood 118, no. 13 (2011): 3670–79. http://dx.doi.org/10.1182/blood-2011-03-341107.

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AbstractNitric oxide (NO) stimulates cGMP synthesis by activating its intracellular receptor, soluble guanylyl cyclase (sGC). It is a currently prevailing concept that No and cGMP inhibits platelet function. However, the data supporting the inhibitory role of NO/sGC/cGMP in platelets have been obtained either in vitro or using whole body gene deletion that affects vessel wall function. Here we have generated mice with sGC gene deleted only in megakaryocytes and platelets. Using the megakaryocyte- and platelet-specific sGC-deficient mice, we identify a stimulatory role of sGC in platelet activa

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Charras, Amandine, Orsia D. Konsta, Christelle Le Dantec, et al. "Cell-specific epigenome-wide DNA methylation profile in long-term cultured minor salivary gland epithelial cells from patients with Sjögren's syndrome." Annals of the Rheumatic Diseases 76, no. 3 (2017): 625–28. http://dx.doi.org/10.1136/annrheumdis-2016-210167.

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ObjectivesThe aetiology of primary Sjögren's syndrome (pSS), also referred to as autoimmune epithelitis, is incompletely understood but includes an epigenetic contribution. Accordingly, the aim of this study was to investigate DNA methylation in salivary gland epithelial cells (SGEC), and to compare results with those publicly available from pSS B and T cells.MethodsLong-term cultured SGEC were selected to conduct an epigenome-wide association study (EWAS) in patients with pSS with comparison to controls using the HumanMethylation 450 K array from Illumina.ResultsThe analysis of differentially

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Madsen, Tracy E., Ghada Bourjeily, Memoona Hasnain, et al. "Article Commentary: Sex- and Gender-Based Medicine: The Need for Precise Terminology." Gender and the Genome 1, no. 3 (2017): 122–28. http://dx.doi.org/10.1089/gg.2017.0005.

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As our knowledge of sex- and gender-based medicine (SGBM) continues to grow, attention to precision in the use of related terminology is critical. Unfortunately, the terms sex and gender are often used interchangeably and incorrectly, both within and outside of the typical binary construct. On behalf of the Sex and Gender Women's Health Collaborative (SGWHC), a national organization whose mission is the integration of SGBM into research, health professions education, and clinical practice, our objective was to develop recommendations for the accurate use of SGBM terminology in research and cli

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Elish, Mahmoud. "Enhanced prediction of vulnerable Web components using Stochastic Gradient Boosting Trees." International Journal of Web Information Systems 15, no. 2 (2019): 201–14. http://dx.doi.org/10.1108/ijwis-05-2018-0041.

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Purpose Effective and efficient software security inspection is crucial as the existence of vulnerabilities represents severe risks to software users. The purpose of this paper is to empirically evaluate the potential application of Stochastic Gradient Boosting Trees (SGBT) as a novel model for enhanced prediction of vulnerable Web components compared to common, popular and recent machine learning models. Design/methodology/approach An empirical study was conducted where the SGBT and 16 other prediction models have been trained, optimized and cross validated using vulnerability data sets from

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Silva, Edson Marchetti da. "Estudo comparativo de indexação complete de texto para recuperação de informações em sistemas gerenciadores de banco de dados." InCID: Revista de Ciência da Informação e Documentação 10, no. 1 (2019): 281–301. http://dx.doi.org/10.11606/issn.2178-2075.v10i1p281-301.

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A indexação completa de textos é uma funcionalidade dos Sistemas Gerenciadores de Bancos de Dados (SGBD) que possibilita a pesquisa e recuperação de informações em documentos de textos de forma eficiente. Dessa forma, foram estudadas e comparadas as características da indexação completa de textos de três produtos de software, objetivando entender a solução mais adequada sob a perspectiva de características das funcionalidades e desempenho da indexação completa de textos destinados a recuperação de informação. Nesse contexto, foi descrita a fundamentação teórica sobre o processo de indexação au

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Sisto, Margherita, Loredana Lorusso, Giuseppe Ingravallo, Roberto Tamma, Domenico Ribatti та Sabrina Lisi. "The TGF-β1 Signaling Pathway as an Attractive Target in the Fibrosis Pathogenesis of Sjögren’s Syndrome". Mediators of Inflammation 2018 (26 листопада 2018): 1–14. http://dx.doi.org/10.1155/2018/1965935.

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Transforming growth factor β1 (TGF-β1) plays a crucial role in the induction of fibrosis, often associated with chronic phases of inflammatory diseases contributing to marked fibrotic changes that compromise normal organ function. The TGF-β1 signal exerts its biological effects via the TGF-β/SMAD/Snail signaling pathway, playing an important pathogenic role in several fibrotic diseases. It has as yet been poorly investigated in the chronic autoimmune disease Sjögren’s syndrome (SS). Here, we firstly tested, by immunohistochemistry, whether the TGF-β1/SMAD/Snail signaling pathway is triggered i

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