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Academic literature on the topic 'Shennong ben cao jing'
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Journal articles on the topic "Shennong ben cao jing"
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Zhang, Min, Na Li, Xiao Bo Qu, Su Luo, and Gregor P. C. Drummen. "Total velvet-antler polypeptide extract from Cervus nippon Temminck induces cell proliferation and activation of the PI3K–Akt signalling pathway in human peripheral blood lymphocytes." Animal Production Science 56, no. 6 (2016): 1008. http://dx.doi.org/10.1071/an15103.
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Velvet antler (VA) has been used for centuries as a traditional medicine to treat a wide range of health problems. VA was first recorded in the Chinese medical classics Shen Nong Ben Cao Jing 2000 years ago. VA has been extensively used to strengthen bones and muscles, promote blood flow and increase immune function. In the present study, we used VA (Cervus nippon Temminck) protein extract (VAPE) to induce cell proliferation and differentiation in human peripheral blood lymphocyte cell line 1301 cells. The results showed that 100 µg/mL of VAPE could significantly induce 1301-cell proliferation (151.3%), increase the population of S-phase cells and increase the expression of CDK4. In addition, VAPE could effectively increase the expression levels of PI3K and Akt and activate PI3K–Akt signal pathway. These findings have provided novel insights into the further understanding of the molecular and signalling pathway mechanisms of VAPE in promoting proliferation of human peripheral blood lymphocyte cells.
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Yang, Baican, Yiwen Yang та Xiaobei Jiang. "Analysis of the application of “Jing (精)” in Ben Cao Gang Mu (《本草纲目》 Compendium of Materia Medica)". Chinese Medicine and Culture 3, № 2 (2020): 99. http://dx.doi.org/10.4103/cmac.cmac_6_20.
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Wang, Shih-Han, Yi-Siao Chen, Kuei-Hung Lai, et al. "Prinsepiae Nux Extract Activates NRF2 Activity and Protects UVB-Induced Damage in Keratinocyte." Antioxidants 11, no. 9 (2022): 1755. http://dx.doi.org/10.3390/antiox11091755.
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Ultraviolet B (UVB) is one of the most important environmental factors that cause extrinsic aging through increasing intracellular reactive oxygen species (ROS) production in the skin. Due to its protective roles against oxidative stress, nuclear factor erythroid-2-related factor (NRF2) has been traditionally considered as a target for skin aging prevention. Here, we identified the extract of Prinsepiae Nux, a top-grade drug listed in Shen Nong Ben Cao Jing, as a potent NRF2 activator by high-throughput screening. A bioassay-guided fractionation experiment revealed that NRF2-activating components were concentrated in the 90% methanol (MP) fraction. MP fraction significantly increased the expression of NRF2 and HO-1 protein and upregulated HO-1 and NQO1 mRNA expression in HaCaT cells. Moreover, MP fraction pre-treatment dramatically reversed UVB-induced depletion of NRF2 and HO-1, accumulation of intracellular ROS, NF-κB activation, and the upregulation of pro-inflammatory genes. Finally, the qualitative analysis using UPLC-tandem mass spectroscopy revealed the most abundant ion peak in MP fraction was identified as α-linolenic acid, which was further proved to activate NRF2 signaling. Altogether, the molecular evidence suggested that MP fraction has the potential to be an excellent source for the discovery of natural medicine to treat/prevent UVB-induced skin damage.
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FUEKI, Tsukasa, Takanori MATSUOKA, Toshiaki MAKINO, et al. "The Weights in Ben Cao Jing Ji Zhu (Dun Huang Version) and the Volume of a Fang Cun Bi (One Cun Square Spoon) : Weights and Measures in the Period when the Shan Han Lun was Written." Kampo Medicine 65, no. 1 (2014): 38–45. http://dx.doi.org/10.3937/kampomed.65.38.
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Zhang, Ting, Shihua Cao, Heng Yuan, and Sunmin Park. "Alleviation of Androgenetic Alopecia with Aqueous Paeonia lactiflora and Poria cocos Extract Intake through Suppressing the Steroid Hormone and Inflammatory Pathway." Pharmaceuticals 14, no. 11 (2021): 1128. http://dx.doi.org/10.3390/ph14111128.
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Paeonia lactiflora Pallas (PL) and Poria cocos Wolf (PC) have been traditionally used to treat inflammatory diseases reported in Dongui Bogam and Shen Nong Ben Cao Jing, traditional medical books in Korean and China, respectively. We determined the efficacies and the molecular mechanisms of PL, PC, and PL + PC aqueous extracts on androgenetic alopecia (AGA) induced by testosterone propionate in C57BL/6 mice. The molecular mechanisms of PL and PC in AGA treatment were examined using experimental assays and network pharmacology. The AGA model was generated by topically applying 0.5% testosterone propionate in 70% ethanol solution to the backs of mice daily for 28 days while the normal-control (Normal-Con; no AGA induction) mice applied 70% ethanol. The 0.1% PL (AGA-PL), 0.1% PC (AGA-PC), 0.05% PL + 0.05% PC (AGA-MIX), and 0.1% cellulose (AGA-Con; control) were supplemented in a high-fat diet for 28 days in AGA-induced mice. Positive-control (AGA-Positive) were administered 2% finasteride daily on the backs of the AGA mice. Hair growth rates decreased in the order of AGA-PL, AGA-MIX, AGA-PC, AGA-Positive, and AGA-Con after 21 days of treatment (ED21). On ED28, skins were completely covered with hair in the AGA-PL and AGA-MIX groups. Serum testosterone concentrations were lower in the AGA-PL group than in the AGA-Con group and similar to concentrations in the Normal-Con group, whereas serum 17β-estradiol concentrations showed the opposite pattern with increasing aromatase mRNA expression (p < 0.05). In the dorsal skin, DKK1 and NR3C2 mRNA expressions were significantly lower, but TGF-β2, β-Catenin, and PPARG expressions were higher in the AGA-PL and AGA-PC groups than in the AGA-Con group (p < 0.05), whereas TNF-α and IL-6 mRNA expressions were lower in the AGA-PL, AGA-MIX, and Normal-Con groups than in the AGA-Con group (p < 0.05). The phosphorylation of Akt and GSK-3β in the dorsal skin was lower in AGA-Con than normal-Con, and PL and MIX ingestion suppressed their decrease similar to the Normal-Con. In conclusion, PL or PL + PC intake had beneficial effects on hair growth similar to Normal-Con. The promotion was related to lower serum testosterone concentrations and pro-inflammatory cytokine levels, and inhibition of the steroid hormone pathway, consistent with network pharmacology analysis findings.
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Jiang, Yuanyuan, Hongfei Wu, Paul Chi Lui Ho, et al. "GC-MS Fingerprinting Combined with Chemical Pattern-Recognition Analysis Reveals Novel Chemical Markers of the Medicinal Seahorse." Molecules 28, no. 23 (2023): 7824. http://dx.doi.org/10.3390/molecules28237824.
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Seahorse is a valuable marine-animal drug widely used in traditional Chinese medicine (TCM), and which was first documented in the “Ben Cao Jing Ji Zhu” during the Liang Dynasty. Hippocampus kelloggi (HK) is the most common seahorse species in the medicinal material market and is one of the genuine sources of medicinal seahorse documented in the Chinese pharmacopeia. It is mainly cultivated in the Shandong, Fujian, and Guangxi Provinces in China. However, pseudo-HK, represented by Hippocampus ingens (HI) due to its similar appearance and traits, is often found in the market, compromising the safety and efficacy of clinical use. Currently, there is a lack of reliable methods for identifying these species based on their chemical composition. In this study, we employed, for the first time, a strategy combining gas chromatography-mass spectrometry (GC-MS) fingerprints and chemical patterns in order to identify HK and HI; it is also the first metabolomic study to date of HI as to chemical components. The obtained results revealed remarkable similarities in the chemical fingerprints, while significant differences were also observed. By employing hierarchical cluster analysis (HCA) and principal component analysis (PCA), based on the relative contents of their characteristic peaks, all 34 samples were successfully differentiated according to their species of origin, with samples from the same species forming distinct clusters. Moreover, nonadecanoic acid and behenic acid were exclusively detected in HK samples, further distinguishing them from HI samples. Additionally, the relative contents of lauric acid, tetradecanoic acid, pentadecanoic acid, n-hexadecanoic acid, palmitoleic acid, margaric acid, oleic acid, fenozan acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) exhibited significant differences between HK and HI (p < 0.0001), as determined by an unpaired t-test. Orthogonal partial least squares discriminant analysis (OPLS-DA) identified seven components (DHA, EPA, n-hexadecanoic acid, tetradecanoic acid, palmitoleic acid, octadecanoic acid, and margaric acid) with high discriminatory value (VIP value > 1). Thus, nonadecanoic acid, behenic acid, and these seven compounds can be utilized as chemical markers for distinguishing HK from HI. In conclusion, our study successfully developed a combined strategy of GC-MS fingerprinting and chemical pattern recognition for the identification of HK and HI, and we also discovered chemical markers that can directly differentiate between the two species. This study can provide a foundation for the authentication of Hippocampus and holds significant importance for the conservation of wild seahorse resources.
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Wang, Panpan, Zhen Wang, Zhanping Zhang, et al. "A review of the botany, phytochemistry, traditional uses, pharmacology, toxicology, and quality control of the Astragalus memeranaceus." Frontiers in Pharmacology 14 (August 23, 2023). http://dx.doi.org/10.3389/fphar.2023.1242318.
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Astragali Radix (Huangqi) is mainly distributed in the Northern Hemisphere, South America, and Africa and rarely in North America and Oceania. It has long been used as an ethnomedicine in the Russian Federation, Mongolia, Korea, Kazakhstan, and China. It was first recorded in the Shennong Ben Cao Jing and includes the effects of reinforcing healthy qi, dispelling pathogenic factors, promoting diuresis, reducing swelling, activating blood circulation, and dredging collaterals. This review systematically summarizes the botanical characteristics, phytochemistry, traditional uses, pharmacology, and toxicology of Astragalus to explore the potential of Huangqi and expand its applications. Data were obtained from databases such as PubMed, CNKI, Wan Fang Data, Baidu Scholar, and Google Scholar. The collected material also includes classic works of Chinese herbal medicine, Chinese Pharmacopoeia, Chinese Medicine Dictionary, and PhD and Master’s theses. The pharmacological effects of the isoflavone fraction in Huangqi have been studied extensively; The pharmacological effects of Huangqi isoflavone are mainly reflected in its anti-inflammatory, anti-tumor, anti-oxidant, anti-allergic, and anti-diabetic properties and its ability to treat several related diseases. Additionally, the medicinal uses, chemical composition, pharmacological activity, toxicology, and quality control of Huangqi require further elucidation. Here, we provide a comprehensive review of the botany, phytochemistry, traditional uses, pharmacology, toxicology, and quality control of Astragalus to assist future innovative research and to identify and develop new drugs involving Huangqi.
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Xie, Danni, Caiyou Song, Tao Qin, et al. "Moschus ameliorates glutamate-induced cellular damage by regulating autophagy and apoptosis pathway." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-45878-7.
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AbstractAlzheimer's disease (AD), a neurodegenerative disorder, causes short-term memory and cognition declines. It is estimated that one in three elderly people die from AD or other dementias. Chinese herbal medicine as a potential drug for treating AD has gained growing interest from many researchers. Moschus, a rare and valuable traditional Chinese animal medicine, was originally documented in Shennong Ben Cao Jing and recognized for its properties of reviving consciousness/resuscitation. Additionally, Moschus has the efficacy of “regulation of menstruation with blood activation, relief of swelling and pain” and is used for treating unconsciousness, stroke, coma, and cerebrovascular diseases. However, it is uncertain whether Moschus has any protective effect on AD patients. We explored whether Moschus could protect glutamate (Glu)-induced PC12 cells from cellular injury and preliminarily explored their related action mechanisms. The chemical compounds of Moschus were analyzed and identified by GC–MS. The Glu-induced differentiated PC12 cell model was thought to be the common AD cellular model. The study aims to preliminarily investigate the intervention effect of Moschus on Glu-induced PC12 cell damage as well as their related action mechanisms. Cell viability, lactate dehydrogenase (LDH), mitochondrial reactive oxygen species, mitochondrial membrane potential (MMP), cell apoptosis, autophagic vacuoles, autolysosomes or autophagosomes, proteins related to apoptosis, and the proteins related to autophagy were examined and analyzed. Seventeen active compounds of the Moschus sample were identified based on GC–MS analysis. In comparison to the control group, Glu stimulation increased cell viability loss, LDH release, mitochondrial damage, loss of MMP, apoptosis rate, and the number of cells containing autophagic vacuoles, and autolysosomes or autophagosomes, while these results were decreased after the pretreatment with Moschus and 3-methyladenine (3-MA). Furthermore, Glu stimulation significantly increased cleaved caspase-3, Beclin1, and LC3II protein expression, and reduced B-cell lymphoma 2/BAX ratio and p62 protein expression, but these results were reversed after pretreatment of Moschus and 3-MA. Moschus has protective activity in Glu-induced PC12 cell injury, and the potential mechanism might involve the regulation of autophagy and apoptosis. Our study may promote research on Moschus in the field of neurodegenerative diseases, and Moschus may be considered as a potential therapeutic agent for AD.
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Wei, Xin, Yun-Lin Peng, Jia-Jun Liang, et al. "Genus Gelsemium and its endophytic fungi - Comprehensive review of their traditional uses, phytochemistry, pharmacology, and toxicology." Current Topics in Medicinal Chemistry 23 (August 25, 2023). http://dx.doi.org/10.2174/1568026623666230825105233.
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Background: The use of ethnic medicinal plants has revitalized wide popularity in Africa, Asia, and most of the world because of the energy consumption barriers increase of synthetic drugs. Gelsemium is a traditional genus of plants with famous cultural and medicinal significance in Southeast Asia and North America. Three species are reported from the genus Gelsemium, including Gelsemium elegans (Gardn. & Camp.) Benth., Gelsemium sempervirens (L.) J.St.-Hil., and Gelsemium rankinii Small. Among them, G. elegans is well known for its toxicity and is used as a traditional remedy for skin problems, neuralgia, fractures, and cancer. The first record of the toxic medicine G. elegans is the Chinese herbal medicine classically known as Shen-Nong Ben-Cao Jing. In the legend, the Shennong emperor was poisoned by G. elegans, hence, it is also well-known as Duan Chang Cao in China. In addition, G. sempervirens tincture is also used in the treatment of inflammation of the spinalcolumn, and diminishes blood to the cerebrospinal centers. Introduction: This review aims to provide up-to-date information on Gelsemium and its endophytic fungi on their traditional uses, phytochemistry, pharmacology, and toxicology. Mechanism studies regarding the detoxification profile of Gelsemium are also reviewed. Methods: For this updated review, the literature survey and search were performed on the scientific databases PubMed, ScienceDirect, Wiley, China CNKI, Web of Science, SciFinder, and Google Scholar using the relevant keywords. Results: The plants of the genus Gelsemium are all reported as rich sources of monoterpene indole alkaloids. Previous phytochemical studies published more than 200 alkaloids from Gelsemium and its endophytic fungi, which have attracted considerable attention from pharmaceutists and phytochemists due to their diverse and complex structures. The bioactivities of Gelsemium phytoconstituents studied using various chemical methods are summarized and described herein. Considering the huge influence of Gelsemium regarding its traditional applications, the activities of isolated compounds were focused on the anti-tumor, anti-inflammatory, analgesic and antianxiety, immunostimulatory, and immunosuppressive properties, which provide evidence supporting the ethnopharmacological effectiveness of the genus Gelsemium. Unlike all previous reviews of genus Gelsemium, to the best of our knowledge, the recently reported natural products from its endophytic fungi are first time summarized in this review. Conclusion: It is clearly suggested from the literature information that the structures and biological activities of Gelsemium have a wide range of attraction from folk to the community of scholars. However, as a highly toxic genus, the work on the detoxification mechanism and toxicology of Gelsemium is urgently needed before entering clinical research. It is noteworthy that the discussion about the relationship between structural and biological activities are a valuable topic of expectation, while the structural modification for active or toxic components may shed light on toxicological breakthrough. Besides the compounds from the plants of genus Gelsemium, the recently reported natural products from its endophytic fungi may provide a supplement for its ethnomedicinal uses and ethnological validity.
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Tong, Lin, Xu Tong, Lei Lei, et al. "Chinese text recognition and knowledge graph of Shen Nong Ben Cao Jing based on BERT pre-trained language models." Guidelines and Standards of Chinese Medicine, May 8, 2024. http://dx.doi.org/10.1097/gscm.0000000000000017.
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Background: The research and utilization of ancient traditional Chinese medicine (TCM) books are relatively limited at present. With the rapid development of artificial intelligence (AI), knowledge graph related technology has brought light on this field. Objective: To construct the knowledge graph of Shen Nong Ben Cao Jing, analyze basic knowledge of materia medica, explore implicit knowledge, and conduct visualization display, as well to provide methodological references for the study of ancient TCM books. Methods: The types of knowledge entities and relationships between entities in Shen Nong Ben Cao Jing were analyzed. A training corpus dataset was produced by using the BIO sequence labeling method; a self-developed CNLP text labeling system was used for text labeling; the BERT model was used to recognize named entities; the relationships between entities were set based on rules and semantic associations; the data into the Neo4j-community 4.4.9 graph database was imported by using Cypher language for storage and visualization display after knowledge fusion; finally, a knowledge graph was constructed. Results: The knowledge graph of Shen Nong Ben Cao Jing included 5, 273 nodes and 11, 064 relationships. The schema layer contained 14 entity types and 15 relationship types. Through the query, knowledge can be visualized from the aspects of classification, property, and seven mutual relationships of herbal combination. Conclusion: The knowledge graph constructed in this study directly reflects the knowledge recorded in Shen Nong Ben Cao Jing and the relationship between them, which is suitable for knowledge mining and intuitive multi-dimensional display of ancient TCM books.
Books on the topic "Shennong ben cao jing"
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1946-, Zheng Jinsheng, ed. Shennong ben cao jing shu. Zhong yi gu ji chu ban she, 2002.
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Hengfen, Wang, ed. Shennong ben cao jing jiao zheng. Jilin ke xue ji shu chu ban she, 1988.
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1945-, Zheng Shaochang, ed. Shennong ben cao jing xin shu. Shanghai gu ji chu ban she, 2013.
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Guoqing, Liang, ed. Shennong ben cao jing tong jian. Wen xing chu ban shi ye you xian gong si, 2006.
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Miao, Xiyong. Zhong yi gu ji zhen ben ji cheng: Ben cao juan : Shennong ben cao jing shu. Hunan ke xue ji shu chu ban she, 2014.
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editor, Wu Yue, ed. Shennong ben cao jing bai zhong lu. Xue yuan chu ban she, 2011.
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Sanyuan, Huang, ed. Shennong ben cao jing du jiao zhu. Ba de jiao yu wen hua chu ban she, 1985.
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