Academic literature on the topic 'Shigella flexneri treatment'

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Journal articles on the topic "Shigella flexneri treatment"

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Bai, Xiangyang, Xuejiao Li, Xue Liu, et al. "Antibacterial Effect of Eugenol on Shigella flexneri and Its Mechanism." Foods 11, no. 17 (2022): 2565. http://dx.doi.org/10.3390/foods11172565.

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Shigella flexneri (Sh. flexneri), which can be found in food and the environment, is a widespread food-borne pathogen that causes human diarrhea termed “shigellosis”. In this study, eugenol, a natural active substance, was investigated for its antibacterial activity against Sh. flexneri. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of eugenol against Sh. flexneri ATCC 12022 was 0.5 and 0.8 mg/mL. The growth curves and inhibitory effect in LB broth, PBS, vegetable juice, and minced pork showed that eugenol had a good activity against Sh. flexneri. Rese
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Noubissi, Paul Aimé, Michel Archange Fokam Tagne, Gaëtan Olivier Fankem, Joseph Ngakou Mukam, Henri Wambe, and René Kamgang. "Effects of Crinum jagus Water/Ethanol Extract on Shigella flexneri-Induced Diarrhea in Rats." Evidence-Based Complementary and Alternative Medicine 2019 (March 12, 2019): 1–10. http://dx.doi.org/10.1155/2019/9537603.

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Diarrheal disease, characterized by the release of more than three loose or liquid stools per day, remains one of the leading causes of morbidity and mortality in children below 5 years of age in developing countries. Many drugs used in diarrhea management face contraindication and, with regard to infectious diarrhea, resistance of some bacterial strains; this therefore increases the need of new alternative and more effective drugs. This study aimed to evaluate anti-Shigella flexneri activities of Crinum jagus water/ethanol extract. In vitro activities were assayed by disc diffusion and agar d
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Clark, Christina S., and Anthony T. Maurelli. "Shigella flexneri Inhibits Staurosporine-Induced Apoptosis in Epithelial Cells." Infection and Immunity 75, no. 5 (2007): 2531–39. http://dx.doi.org/10.1128/iai.01866-06.

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ABSTRACT Shigella flexneri is a facultative intracellular organism that causes bacillary dysentery. The Shigella IpaB protein activates caspase 1 in macrophages, which eventually leads to apoptosis. In contrast, epithelial cells infected with Shigella undergo a stress response but do not die. Therefore, the objective of this study was to determine if Shigella has the ability to inhibit apoptosis in epithelial cells. A modified gentamicin protection assay was used to investigate if HeLa cells infected with S. flexneri are able to resist the induction of apoptosis following treatment with 4 μM o
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Subramani, Parimala, Bharathi Ramachandra, Beena Pavangada Madappa, and Arvind Natarajan. "Speciation and Antibiotic Susceptibility Pattern of Shigella isolates in a Rural Tertiary Care Hospital, Kolar." Journal of Pure and Applied Microbiology 16, no. 1 (2022): 276–80. http://dx.doi.org/10.22207/jpam.16.1.16.

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Shigellosis is the most important cause of bacillary dysentery. It’s a major public health problem. It is endemic in many developing countries resulting in a significant amount of mortality and morbidity. The incidence is 90 million with 6,00,000 deaths world over. In India, there is an emergence of resistance to Shigella resulting in limitation of treatment. To study the prevalence of Shigella species and their antibiogram in stool samples obtained from patients treated for dysentery at Rural Tertiary Care Hospital. A retrospective analysis of the Shigella isolates obtained from 400 stool sam
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Zakir Hossain, A. K. M., Md Zahid Hasan, Sohana Akter Mina, Nahid Sultana, and A. M. Masudul Azad Chowdhury. "Occurrence of shigellosis in pediatric diarrheal patients in Chattogram, Bangladesh: A molecular based approach." PLOS ONE 18, no. 6 (2023): e0275353. http://dx.doi.org/10.1371/journal.pone.0275353.

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Shigellaa Gram-negative, non-motile bacillus, is the primary causative agent of the infectious disease shigellosis, which kills 1.1 million people worldwideevery year. The children under the age of five are primarily the victims of this disease. This study has been conducted to assess the prevalence of shigellosis through selective plating, biochemical test and conventional PCR assays, where the samples were collected from suspected diarrheoal patients. Invasive plasmid antigen H (ipaH) and O-antigenic rfc gene were used to identify Shigella spp. and S. flexneri respectively. For validation of
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Piryaei, Masoumeh, Anahita Motamedi, and Atefeh Mehrabi Far. "Investigation of Intestinal Enzyme Activity and Effects of Non-starch Polysaccharide on it." International Journal of Engineering & Technology 7, no. 4.7 (2018): 23. http://dx.doi.org/10.14419/ijet.v7i4.7.20372.

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Background and Purpose: Shigella is a human shigellosis and its lipopolysaccharide is identified by 4TLR. The 4TLR is a family of pseudo-TOLL receptors and many immune routes are triggered by stimulating these receptors. Many studies show increasing of 4TLR expression in Mesenchyme stem cells under the influence of lipopolysaccharide. The main objective of this study was to identify the appropriate lipopolysaccharide of Shigella strains by stimulating the immune system for vaccine studies. Materials and Methods: In this experimental study, the stem cell of human Mesenchymal derived from bone m
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Shireen, Tasnina, Mahfuzur R. Sarker, and Zia U. Ahmed. "Studies on transformation in Shigella." Canadian Journal of Microbiology 36, no. 5 (1990): 348–51. http://dx.doi.org/10.1139/m90-060.

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Transformation of pBR322 DNA into Shigella occurred at a low frequency. The efficiency of transformation was highest in S. dysenteriae 1 and lowest in S. flexneri. Treatment of cells with CaCl2 for a prolonged period (24 h) increased the efficiency of transformation in all strains, except in S. flexneri, where transformation efficiency could not be improved by a variety of manipulations. Transformation efficiency did not increase in any of the strains when transformation was carried out with plasmid DNA obtained from a transformant (homologous transformation), suggesting the absence of a stron
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Guyot, A. "Antibiotic Resistance of Shigella in Monrovia." Tropical Doctor 26, no. 2 (1996): 70–71. http://dx.doi.org/10.1177/004947559602600209.

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Twenty Shigella strains were isolated from bloody stools, of which 10 had been collected from children. Eighty per cent of the Shigella isolates were serogrouped as S. flexneri. All 20 Shigella strains were susceptible to gentamicin, nalidixic acid and ciprofloxacin. More than 80% were resistant to ampicillin, cotrimoxazole and tetracycline and 65% were resistant to chloramphenicol. Ten of 20 Shigella isolates showed a quadruple resistance to all four antibiotics. The usefulness of nalidixic acid for the treatment of multiresistant Shigella infections is discussed.
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Fu, Hua, Wenchuan Leng, Jing Wang, et al. "Transcriptional profile induced by furazolidone treatment of Shigella flexneri." Applied Microbiology and Biotechnology 77, no. 3 (2007): 657–67. http://dx.doi.org/10.1007/s00253-007-1180-9.

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Kurakin, E. S. "Bacteriophage use in the focus of hospital-acquired shigellosis." Kazan medical journal 98, no. 6 (2017): 917–21. http://dx.doi.org/10.17750/kmj2017-917.

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Aim. Evaluation of epidemiologic effectiveness of polyvalent dysentery bacteriophage use for management of infection outbreak caused by Shigella flexneri. Methods. Investigation was performed in Tula psychoneurological hospital where the persistent focus of shigellosis was formed by Sh. flexneri 2a. As part of the study, evaluation of efficacy of antibacterial treatment (ciprofloxacin 250 mg per day for 7 days - group 1) was performed by evaluating duration of bacterial excretion in 18 patients with mild, 21 with moderate and 2 with severe Shigella infection. At the same time efficacy of Shige
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Conference papers on the topic "Shigella flexneri treatment"

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Floares, Doris, Diana Obistioiu, Anca Hulea, Ersilia Alexa, and Isidora Radulov. "THUJA OCCIDENTALIS AND PLATYCLADUS ORIENTALIS ANTIMICROBIAL ACTIVITY." In 23rd SGEM International Multidisciplinary Scientific GeoConference 2023. STEF92 Technology, 2023. http://dx.doi.org/10.5593/sgem2023v/6.2/s25.57.

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The rise of bacterial resistance to currently employed antibiotics is causing growing concerns for public health. The emergence of highly resistant bacterial strains results in the ineffectiveness of antibiotic treatments against many bacterial infections. As a result, there is an ongoing quest for new antimicrobial agents. This pursuit can take two main directions: one involves the design and synthesis of novel agents, while the other involves exploring natural sources to uncover previously undiscovered antimicrobial compounds. Herbal medications, particularly, have garnered renewed interest
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