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Journal articles on the topic 'SHIME®'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Zhu, Wei, Xiaoyong Zhang, Dong Wang, Qinghua Yao, Guang-Lei Ma, and Xiaohui Fan. "Simulator of the Human Intestinal Microbial Ecosystem (SHIME®): Current Developments, Applications, and Future Prospects." Pharmaceuticals 17, no. 12 (2024): 1639. https://doi.org/10.3390/ph17121639.

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The human gastrointestinal microbiota plays a vital role in maintaining host health and preventing diseases, prompting the creation of simulators to replicate this intricate system. The Simulator of the Human Intestinal Microbial Ecosystem (SHIME®), a multicompartment dynamic simulator, has emerged as a pivotal in vitro model for studying the interactions and interferences within the human gut microbiota. The continuous and real-time monitoring hallmarks, along with the programmatically flexible setup, bestow SHIME® with the ability to mimic the entire human intestinal ecosystem with high dyna

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RUDZKA, AGNIESZKA, ONDŘEJ PATLOKA, MAGDALENA PŁECHA, et al. "CHANGES IN THE MICROBIOME OF A HUMAN AND IN THE SIMULATOR OF HUMAN INTESTINAL MICROBIAL ECOSYSTEM (SHIME®) IN RESPONSE TO A DIET AND PROBIOTIC SUPPLEMENTATION." Zywnosc Nauka Technologia Jakosc/Food Science Technology Quality 134, no. 1 (2023): 53–72. http://dx.doi.org/10.15193/zntj/2023/134/437.

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Background. The Simulator of Human Intestinal Microbial Ecosystem (SHIME®) is used to study the behavior of a human microbiome in response to various factors. The aim of this study was to simultaneously demonstrate changes in the microbiome of a human volunteer and in the SHIME® system in response to a change in a diet and probiotic therapy due to a scarcity of published research with similar design. Results and conclusions. The probiotic therapy resulted in a decrease in fasting insulin and glucose (by 18 % and 13 %, respectively), while the increased fiber intake in the experimental diet see

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Giuliani, Camilla, Massimo Marzorati, Marzia Innocenti, et al. "Dietary supplement based on stilbenes: a focus on gut microbial metabolism by the in vitro simulator M-SHIME®." Food & Function 7, no. 11 (2016): 4564–75. http://dx.doi.org/10.1039/c6fo00784h.

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Van den Abbeele, Pieter, Norbert Sprenger, Jonas Ghyselinck, Benoît Marsaux, Massimo Marzorati, and Florence Rochat. "A Comparison of the In Vitro Effects of 2’Fucosyllactose and Lactose on the Composition and Activity of Gut Microbiota from Infants and Toddlers." Nutrients 13, no. 3 (2021): 726. http://dx.doi.org/10.3390/nu13030726.

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Because of the recognized health benefits of breast milk, it is recommended as the sole nutrition source during the first 6 months of life. Among the bioactive components are human milk oligosaccharides (HMOs) that exert part of their activity via the gut microbiota. Here, we investigated the gut microbiota fermentation of HMO 2’fucosyllactose (2’-FL), using two in vitro models (48 h fecal incubations and the long-term mucosal simulator of the human intestinal microbial ecosystem [M-SHIME®]) with fecal samples from 3-month-old breastfed (BF) infants as well as 2–3 year old toddlers. The short-

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Giuliani, Marzorati, Daghio, et al. "Effects of Olive and Pomegranate By-Products on Human Microbiota: A Study Using the SHIME® in Vitro Simulator." Molecules 24, no. 20 (2019): 3791. http://dx.doi.org/10.3390/molecules24203791.

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Two by-products containing phenols and polysaccharides, a “pâté” (OP) from the extra virgin olive oil milling process and a decoction of pomegranate mesocarp (PM), were investigated for their effects on human microbiota using the SHIME® system. The ability of these products to modulate the microbial community was studied simulating a daily intake for nine days. Microbial functionality, investigated in terms of short chain fatty acids (SCFA) and NH4+, was stable during the treatment. A significant increase in Lactobacillaceae and Bifidobacteriaceae at nine days was induced by OP mainly in the p

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Marsaux, Benoît, Frédéric Moens, Massimo Marzorati та Tom Van de Wiele. "The Intricate Connection between Bacterial α-Diversity and Fungal Engraftment in the Human Gut of Healthy and Impaired Individuals as Studied Using the In Vitro SHIME® Model". Journal of Fungi 9, № 9 (2023): 877. http://dx.doi.org/10.3390/jof9090877.

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From the estimated 2.2 to 3.8 million fungal species existing on Earth, only a minor fraction actively colonizes the human gastrointestinal tract. In fact, these fungi only represent 0.1% of the gastrointestinal biosphere. Despite their low abundance, fungi play dual roles in human health—both beneficial and detrimental. Fungal infections are often associated with bacterial dysbiosis following antibiotic use, yet our understanding of gut fungi–bacteria interactions remains limited. Here, we used the SHIME® gut model to explore the colonization of human fecal-derived fungi across gastrointestin

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Sato, Yohei, Masaya Kanayama, Shiori Nakajima, Yukihiro Hishida, and Yuta Watanabe. "Sialyllactose Enhances the Short-Chain Fatty Acid Production and Barrier Function of Gut Epithelial Cells via Nonbifidogenic Modification of the Fecal Microbiome in Human Adults." Microorganisms 12, no. 2 (2024): 252. http://dx.doi.org/10.3390/microorganisms12020252.

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Although various benefits of human milk oligosaccharides (HMOs) have been reported, such as promoting Bifidobacterium growth in the infant gut, their effects on adults have not been fully studied. This study investigated the effects of two types of sialyllactose, 3′-sialyllactose (3′-SL) and 6′-sialyllactose (6′-SL), on the adult intestinal microbiome using the simulator of human intestinal microbial ecosystem (SHIME®), which can simulate human gastrointestinal conditions. HPLC metabolite analysis showed that sialyllactose (SL) supplementation increased the short-chain fatty acid content of SH

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De Weirdt, R., E. Coenen, B. Vlaeminck, V. Fievez, P. Van den Abbeele, and T. Van de Wiele. "A simulated mucus layer protects Lactobacillus reuteri from the inhibitory effects of linoleic acid." Beneficial Microbes 4, no. 4 (2013): 299–312. http://dx.doi.org/10.3920/bm2013.0017.

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Lactobacillus reuteri is a commensal, beneficial gut microbe that colonises the intestinal mucus layer, where it makes close contact with the human host and may significantly affect human health. Here, we investigated the capacity of linoleic acid (LA), the most common polyunsaturated fatty acid (PUFA) in a Western-style diet, to affect L. reuteri ATCC PTA 6475 prevalence and survival in a simulated mucus layer. Short-term (1 h) survival and mucin-agar adhesion assays of a log-phase L. reuteri suspension in intestinal water demonstrated that the simulated mucus layer protected L. reuteri again

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Mazier, Wilfrid, Katy Le Corf, Ccori Martinez, et al. "A New Strain of Christensenella minuta as a Potential Biotherapy for Obesity and Associated Metabolic Diseases." Cells 10, no. 4 (2021): 823. http://dx.doi.org/10.3390/cells10040823.

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Obesity is associated with gut microbiota dysbiosis, characterized by a high Firmicutes/Bacteroidetes ratio. Gut-dwelling bacteria of the Christensenellaceae family have been proposed to act as keystones of the human gut ecosystem and to prevent adipogenesis. The objectives of the present study were to demonstrate the antiobesity potential of a new strain of Christensenella minuta in preclinical models and explore related mechanisms of action. The antiobesity potential of C. minuta DSM33407 was assessed in a diet-induced obesity mouse model. Changes in hepatic lipid metabolism were explored us

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Marzorati, Massimo, Sarah Bubeck, Thomas Bayne, Kiran Krishnan, and Aicacia Young. "Evaluation of the Effect of Food Products Containing Prebiotics and Bacillus subtilis HU58 on the Gut Microbial Community Activity and Community Composition Using an In Vitro M-SHIME® Model." Applied Sciences 11, no. 24 (2021): 11963. http://dx.doi.org/10.3390/app112411963.

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GoodBiome™ Foods is a collection of foods infused with prebiotics, including inulin and xylooligosaccharides, and the probiotic Bacillus subtilis HU58. The effects of repeated intake of three predigested GoodBiome™ Foods products and one comparator product on microbial community activity and composition were assessed using the mucosal simulator of the human intestinal microbial system (M-SHIME®) platform with proximal colon (PC) and distal colon (DC) compartments and conducted under healthy gut conditions. Treatment with all test products increased short-chain fatty acid (SCFA) production (ace

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Borgonovi, Tais Fernanda, Mateus Kawata Salgaço, Gislane Lelis Vilela de Oliveira, et al. "Functional Fermented Milk with Fruit Pulp Modulates the In Vitro Intestinal Microbiota." Foods 11, no. 24 (2022): 4113. http://dx.doi.org/10.3390/foods11244113.

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The effect of putative probiotic fermented milk (FM) with buriti pulp (FMB) or passion fruit pulp (FMPF) or without fruit pulp (FMC) on the microbiota of healthy humans was evaluated. FM formulations were administered into a simulator of the human intestinal microbial ecosystem (SHIME®) to evaluate the viability of lactic acid bacteria (LAB), microbiota composition, presence of short-chain fatty acids (SCFA), and ammonium ions. The probiotic LAB viability in FM was affected by the addition of the fruit pulp. Phocaeicola was dominant in the FMPF and FMB samples; Bifidobacterium was related to F

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Kirby, Trevor O., Jeremy R. Townsend, Philip A. Sapp, et al. "The Novel Synbiotic, AG1®, Increases Short-Chained Fatty Acid Production in the Simulator of Human Intestinal Microbial Ecosystem (SHIME) Model®." Nutraceuticals 3, no. 4 (2023): 489–98. http://dx.doi.org/10.3390/nutraceuticals3040035.

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Recently, there is growing usage of prebiotics and probiotics as dietary supplements due to their purported health benefits. AG1® (AG1) is a novel foundational nutrition supplement which contains vitamins, minerals, phytonutrients, wholefood concentrates, adaptogens, and functional mushrooms. AG1 could be classified as a synbiotic because it contains traditional and non-traditional prebiotics (e.g., inulin and phytonutrients) as well as lactic-acid-producing probiotics. The purpose of this study was to employ the Simulator of Human Intestinal Microbial Ecosystem (SHIME®) model, which measures

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13

Liu, LinShu, Karley K. Mahalak, Jamshed T. Bobokalonov, et al. "Impact of Ivermectin on the Gut Microbial Ecosystem." International Journal of Molecular Sciences 24, no. 22 (2023): 16125. http://dx.doi.org/10.3390/ijms242216125.

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Ivermectin is a an anti-helminthic that is critical globally for both human and veterinary care. To the best of our knowledge, information available regarding the influence of ivermectin (IVM) on the gut microbiota has only been collected from diseased donors, who were treated with IVM alone or in combination with other medicines. Results thus obtained were influenced by multiple elements beyond IVM, such as disease, and other medical treatments. The research presented here investigated the impact of IVM on the gut microbial structure established in a Triple-SHIME® (simulator of the human inte

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Marzorati, Massimo, Pieter Van den Abbeele, Sarah S. Bubeck, et al. "Bacillus subtilis HU58 and Bacillus coagulans SC208 Probiotics Reduced the Effects of Antibiotic-Induced Gut Microbiome Dysbiosis in an M-SHIME® Model." Microorganisms 8, no. 7 (2020): 1028. http://dx.doi.org/10.3390/microorganisms8071028.

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Benefits associated with probiotic use have been reported; however, the mechanisms behind these benefits are poorly understood. The effects of a probiotic formulation (MegaDuo™) containing Bacillus coagulans SC208 and Bacillus subtilis HU58 on intestinal permeability and immune markers was assessed using a combination of the in vitro gut model, the mucosal simulator of the human intestinal microbial ecosystem (M-SHIME®), and an in vitro inflammatory bowel disease-like Caco-2/THP1 co-culture model in both healthy and antibiotic-induced dysbiosis conditions. Established M-SHIME® proximal colon v

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Marzorati, Massimo, Sarah Bubeck, Thomas Bayne, Kiran Krishnan, and Morgan Giusto. "A Spore-Based Probiotic Containing Five Strains of Bacillus Had No Notable Effect on the Recovery of the Activity and Composition of the Baby Gut Microbiota Following Antibiotic Treatment in an In Vitro Model." Applied Sciences 12, no. 23 (2022): 12302. http://dx.doi.org/10.3390/app122312302.

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Antibiotic use causes dysbiosis; probiotic treatment may mitigate these effects by promoting the growth of beneficial bacteria and restoring a healthy gut microbiota. The effects of a probiotic formulation (MegaSporeBiotic™; Bacillus indicus [HU36], Bacillus subtilis [HU58], Bacillus coagulans [SC208], Bacillus licheniformis [SL307], and Bacillus clausii [SC109]) on the microbial community activity and composition of the baby gut microbiome were evaluated using the in vitro gut model, the mucosal simulator of the human intestinal microbial system (M-SHIME®), and fecal samples from four babies

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Rodrigues, Vivian Cristina da Cruz, Ana Luiza Rocha Faria Duque, Luciana de Carvalho Fino, et al. "Modulation of the intestinal microbiota and the metabolites produced by the administration of ice cream and a dietary supplement containing the same probiotics." British Journal of Nutrition 124, no. 1 (2020): 57–68. http://dx.doi.org/10.1017/s0007114520000896.

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AbstractThe aim of the present work was to compare the capacity to modulate the intestinal microbiota and the production of metabolites after 14 d administration of a commercial dietary supplement and a manufactured ice cream, both containing the same quantity of inulin and the same viable counts of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis BB-12, using the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) model. Samples of the colonic contents were evaluated microbiologically by real-time quantitative PCR (qRT-PCR) and next-generation sequencing and chemically b

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Salgaço, Mateus Kawata, Fellipe Lopes de Oliveira, Adilson Sartoratto, Victoria Mesa, Marcia Pinto Alves Mayer, and Katia Sivieri. "Impact of Lactobacillus acidophilus—La5 on Composition and Metabolism of the Intestinal Microbiota of Type 2 Diabetics (T2D) and Healthy Individuals Using a Microbiome Model." Fermentation 9, no. 8 (2023): 740. http://dx.doi.org/10.3390/fermentation9080740.

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Type 2 diabetes is characterized by dysbiosis in the gut, which may lead to systemic inflammation. Therefore, the use of probiotics may help to achieve a balanced microbiota and improve glycemic control. The aim of this study was to verify the impact of Lactobacillus acidophilus—La5 on the gut microbiome of type 2 diabetes adults using the Human Gut Microbial Ecosystem Simulator (SHIME®) and compare this to the microbiome of healthy subjects. Four groups (Control Group: NormoGlycemic; Treatment Group: T2D) were evaluated in SHIME® for 6 weeks. After 7 and 14 days of colonic fermentation, the i

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Truchado, P., P. Van den Abbeele, A. Rivière, S. Possemiers, L. De Vuyst, and T. Van de Wiele. "Bifidobacterium longum D2 enhances microbial degradation of long-chain arabinoxylans in an in vitro model of the proximal colon." Beneficial Microbes 6, no. 6 (2015): 849–60. http://dx.doi.org/10.3920/bm2015.0023.

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Long-chain arabinoxylans (LC-AX) are degraded in the colon by intestinal bacteria possessing AX-degrading enzymes, such as bifidobacteria. Enzymatic activity of intestinal bacterial might vary depending on the composition of the gut microbiota. To compare the enzymatic activities of the bacterial gut communities of two healthy individuals (donors D1 and D2), these bacterial communities were inoculated into in vitro model M-SHIME®. Differences in xylanase activities and denaturing gradient gel electrophoresis profiles, in particular a DNA-band corresponding with Bifidobacterium longum, were fou

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Govaert, Marlies, Cindy Duysburgh, Brendan Kesler, and Massimo Marzorati. "Effects of NatureKnit™, a Blend of Fruit and Vegetable Fibers Rich in Naturally Occurring Bound Polyphenols, on the Metabolic Activity and Community Composition of the Human Gut Microbiome Using the M-SHIME® Gastrointestinal Model." Microorganisms 13, no. 3 (2025): 613. https://doi.org/10.3390/microorganisms13030613.

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This study evaluated the impact of a proprietary blend of fruit and vegetable fibers rich in naturally occurring bound polyphenols (commercially marketed as NatureKnitTM), compared to purified fibers (inulin and psyllium), on the human gut microbiome using the validated M-SHIME® gastrointestinal model. A short-term single-stage colonic M-SHIME® experiment (with fecal inoculum from three healthy human donors) was used to evaluate the test products compared to a negative control. Samples were assessed for pH, gas pressure, short-chain fatty acid (SCFA) production, lactate, and ammonium from 0 h

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Cesar, Thais, Mateus Kawata Salgaço, Victoria Mesa, Adilson Sartoratto, and Katia Sivieri. "Exploring the Association between Citrus Nutraceutical Eriocitrin and Metformin for Improving Pre-Diabetes in a Dynamic Microbiome Model." Pharmaceuticals 16, no. 5 (2023): 650. http://dx.doi.org/10.3390/ph16050650.

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Pre-diabetes is recognized as an altered metabolic state, which precedes type 2 diabetes, and it is associated with great dysfunction of the intestinal microbiota, known as dysbiosis. Natural compounds, capable of reducing blood glucose without side effects and with a beneficial effect on the microbiota, have been studied as substitutes or adjuvants to conventional hypoglycemic agents, such as metformin. In this work, the effect of the nutraceutical Eriomin®, a mixture of citrus flavonoids (eriocitrin, hesperidin, naringin, and didymin), which reduces glycemia and increases glucagon-like pepti

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Tabare, Emilie, Tiffany Dauchot, Christel Cochez, et al. "Eudragit® FS Microparticles Containing Bacteriophages, Prepared by Spray-Drying for Oral Administration." Pharmaceutics 15, no. 6 (2023): 1602. http://dx.doi.org/10.3390/pharmaceutics15061602.

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Phage therapy is recognized to be a promising alternative to fight antibiotic-resistant infections. In the quest for oral dosage forms containing bacteriophages, the utilization of colonic-release Eudragit® derivatives has shown potential in shielding bacteriophages from the challenges encountered within the gastrointestinal tract, such as fluctuating pH levels and the presence of digestive enzymes. Consequently, this study aimed to develop targeted oral delivery systems for bacteriophages, specifically focusing on colon delivery and employing Eudragit® FS30D as the excipient. The bacteriophag

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Kirby, Trevor O., Philip A. Sapp, Jeremy R. Townsend, et al. "AG1® Induces a Favorable Impact on Gut Microbial Structure and Functionality in the Simulator of Human Intestinal Microbial Ecosystem® Model." Current Issues in Molecular Biology 46, no. 1 (2024): 557–69. http://dx.doi.org/10.3390/cimb46010036.

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Modulation of the human gut microbiome has become an area of interest in the nutraceutical space. We explored the effect of the novel foundational nutrition supplement AG1® on the composition of human microbiota in an in vitro experimental design. Employing the Simulator of Human Intestinal Microbial Ecosystem (SHIME®) model, AG1® underwent digestion, absorption, and subsequent colonic microenvironment simulation under physiologically relevant conditions in healthy human fecal inocula. Following 48 h of colonic simulation, the gut microbiota were described using shallow shotgun, whole genome s

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Sivieri, Katia, Martha L. Villarreal Morales, Susana M. I. Saad, Maria A. Tallarico Adorno, Isabel Kimiko Sakamoto, and Elizeu A. Rossi. "Prebiotic Effect of Fructooligosaccharide in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®Model)." Journal of Medicinal Food 17, no. 8 (2014): 894–901. http://dx.doi.org/10.1089/jmf.2013.0092.

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Bondue, Pauline, Sarah Lebrun, Bernard Taminiau, et al. "Effect of Bifidobacterium crudilactis and 3′-sialyllactose on the toddler microbiota using the SHIME® model." Food Research International 138 (December 2020): 109755. http://dx.doi.org/10.1016/j.foodres.2020.109755.

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Blancquaert, Laura, Chris Vervaet, and Wim Derave. "Predicting and Testing Bioavailability of Magnesium Supplements." Nutrients 11, no. 7 (2019): 1663. http://dx.doi.org/10.3390/nu11071663.

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Despite the presumption of the beneficial effects of magnesium supplementation, little is known about the pharmacokinetics of different magnesium formulations. We aimed to investigate the value of two in vitro approaches to predict bioavailability of magnesium and to validate this in subsequent in vivo testing. In vitro assessment of 15 commercially available magnesium formulations was performed by means of a Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) and by dissolution tests. Two magnesium formulations with contrasting bioavailability prediction from both in vitro tests (b

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De Oliveira, Fellipe Lopes, Mateus Kawata Salgaço, Marina Toscano de Oliveira, et al. "Exploring the Potential of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 as Promising Psychobiotics Using SHIME." Nutrients 15, no. 6 (2023): 1521. http://dx.doi.org/10.3390/nu15061521.

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Psychobiotics are probiotics that have the characteristics of modulating central nervous system (CNS) functions or reconciled actions by the gut–brain axis (GBA) through neural, humoral and metabolic pathways to improve gastrointestinal activity as well as anxiolytic and even antidepressant abilities. The aim of this work was to evaluate the effect of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 on the gut microbiota of mildly anxious adults using SHIME®. The protocol included a one-week control period and two weeks of treatment with L. helveticus R0052 and B. longum R0175.

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Salgaço, Mateus Kawata, Natália Partis Perina, Thaís Moreno Tomé, et al. "Probiotic infant cereal improves children’s gut microbiota: Insights using the Simulator of Human Intestinal Microbial Ecosystem (SHIME®)." Food Research International 143 (May 2021): 110292. http://dx.doi.org/10.1016/j.foodres.2021.110292.

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Joly Condette, Claire, Narimane Djekkoun, Julie Reygner, et al. "Effect of daily co-exposure to inulin and chlorpyrifos on selected microbiota endpoints in the SHIME® model." Environmental Pollution 302 (June 2022): 118961. http://dx.doi.org/10.1016/j.envpol.2022.118961.

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Marzorati, Massimo, Véronique Maquet, and Sam Possemiers. "Fate of chitin-glucan in the human gastrointestinal tract as studied in a dynamic gut simulator (SHIME®)." Journal of Functional Foods 30 (March 2017): 313–20. http://dx.doi.org/10.1016/j.jff.2017.01.030.

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Hernandez-Hernandez, Oswaldo. "In vitro Gastrointestinal Models for Prebiotic Carbohydrates: A Critical Review." Current Pharmaceutical Design 25, no. 32 (2019): 3478–83. http://dx.doi.org/10.2174/1381612825666191011094724.

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Background: In the last decade, various consortia and companies have created standardized digestion protocols and gastrointestinal simulators, such as the protocol proposed by the INFOGEST Consortium, the simulator SHIME, the simulator simgi®, the TIM, etc. Most of them claim to simulate the entire human gastrointestinal tract. However, few results have been reported on the use of these systems with potential prebiotic carbohydrates. Methods: This critical review addresses the existing data on the analysis of prebiotic carbohydrates by different in vitro gastrointestinal simulators, the lack o

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Kirby, Trevor O., Philip A. Sapp, Jeremy R. Townsend, et al. "Changes in the fecal polar metabolome due to AG1 supplementation in the SHIME® model: A proof of principle study." Journal of Functional Foods 119 (August 2024): 106319. http://dx.doi.org/10.1016/j.jff.2024.106319.

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Terpend, Kathleen, Sam Possemiers, David Daguet, and Massimo Marzorati. "Arabinogalactan and fructo-oligosaccharides have a different fermentation profile in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®)." Environmental Microbiology Reports 5, no. 4 (2013): 595–603. http://dx.doi.org/10.1111/1758-2229.12056.

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Fanny, Laforêt, Antoine Céline, Lebrun Sarah, et al. "Impact Assessment of vB_KpnP_K1-ULIP33 Bacteriophage on the Human Gut Microbiota Using a Dynamic In Vitro Model." Viruses 15, no. 3 (2023): 719. http://dx.doi.org/10.3390/v15030719.

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New control methods are needed to counter antimicrobial resistances and the use of bacteriophages as an alternative treatment seems promising. To that end, the effect of the phage vB_KpnP_K1-ULIP33, whose host is the hypervirulent Klebsiella pneumoniae SA12 (ST23 and capsular type K1), was assessed on intestinal microbiota, using an in vitro model: the SHIME® system (Simulator of the Human Intestinal Microbial Ecosystem). After stabilization of the system, the phage was inoculated for 7 days and its persistence in the different colons was studied until its disappearance from the system. The co

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Kamil, Alison, Lisa Fleige, YiFang Chu, Peter John De Chavez, Cindy Duysburgh та Pieter Van den Abbeele. "Oats Containing 1.4g β-Glucan Significantly Increased Lactobacillus Levels In Vitro using M-SHIME® Model and In Vivo in Healthy Adults with Elevated Cholesterol Levels". Current Developments in Nutrition 4, Supplement_2 (2020): 1567. http://dx.doi.org/10.1093/cdn/nzaa062_024.

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Abstract Objectives Preliminary evidence, primarily animal and in vitro studies, suggests that oats selectively impact the microbiota. We conducted an in vitro screening trial, using the M-SHIME model®, with fecal inoculum from healthy adult donors with elevated cholesterol levels to determine the effect of 1 serving (40g) of Quaker Old-Fashioned Oats (OFO) containing 1.4g β-Glucan (βG). We also conducted a clinical trial to confirm the in vitro effect of OFO in vivo using fecal material obtained from a similar subject population. Methods In Vitro Trial- Validated M-SHIME model of the entire G

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Reygner, Julie, Claire Joly Condette, Aurélia Bruneau, et al. "Changes in Composition and Function of Human Intestinal Microbiota Exposed to Chlorpyrifos in Oil as Assessed by the SHIME® Model." International Journal of Environmental Research and Public Health 13, no. 11 (2016): 1088. http://dx.doi.org/10.3390/ijerph13111088.

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Ruiz-Álvarez, Blanca Elizabeth, Valentina Cattero, and Yves Desjardins. "Prebiotic-like Effects of Proanthocyanidin-Rich Aronia Extract Supplementation on Gut Microbiota Composition and Function in the Twin-M-SHIME® Model." Pharmaceuticals 18, no. 6 (2025): 793. https://doi.org/10.3390/ph18060793.

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Background: Phenolic compounds, particularly anthocyanins and proanthocyanidins (PACs), are poorly absorbed in the upper digestive tract and reach the colon largely intact, where they may influence gut microbiota (GM) composition and, in turn, impact host health. We hypothesized that a PAC-rich aronia extract would beneficially modulate the GM, promote the growth of health-associated bacteria, and enhance short-chain fatty acid (SCFA) production across different colon sections, with partial reversion effects after supplementation ends. Methods: The Twin-M-SHIME® system was used to simulate the

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Duysburgh, Cindy, Pieter Van den Abbeele, Alison Kamil, et al. "In vitro–in vivo Validation of Stimulatory Effect of Oat Ingredients on Lactobacilli." Pathogens 10, no. 2 (2021): 235. http://dx.doi.org/10.3390/pathogens10020235.

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The prebiotic activity of a commercially available oat product and a novel oat ingredient, at similar β-glucan loads, was tested using a validated in vitro gut model (M-SHIME®). The novel oat ingredient was tested further at lower β-glucan loads in vitro, while the commercially available oat product was assessed in a randomised, single-blind, placebo-controlled, and cross-over human study. Both approaches focused on healthy individuals with mild hypercholesterolemia. In vitro analysis revealed that both oat products strongly stimulated Lactobacillaceae and Bifidobacteriaceae in the intestinal

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Antoine, Céline, Fanny Laforêt, Elizabeth Goya-Jorge, et al. "Phage Targeting Neonatal Meningitis E. coli K1 In Vitro in the Intestinal Microbiota of Pregnant Donors and Impact on Bacterial Populations." International Journal of Molecular Sciences 24, no. 13 (2023): 10580. http://dx.doi.org/10.3390/ijms241310580.

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Escherichia coli K1 is a leading cause of neonatal meningitis. The asymptomatic carriage of these strains in the maternal intestinal microbiota constitutes a risk of vertical transmission to the infant at birth. The aim of this work was to evaluate the efficacy of phage therapy against E. coli K1 in an intestinal environment and its impact on the intestinal microbiota. For this purpose, three independent experiments were conducted on the SHIME® system, the first one with only the phage vB_EcoP_K1_ULINTec4, the second experiment with only E. coli K1 and the last experiment with both E. coli K1

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Pham, Van T., Robert E. Steinert, Cindy Duysburgh, Jonas Ghyselinck, Massimo Marzorati, and Peter J. T. Dekker. "In Vitro Effect of Enzymes and Human Milk Oligosaccharides on FODMAP Digestion and Fecal Microbiota Composition." Nutrients 15, no. 7 (2023): 1637. http://dx.doi.org/10.3390/nu15071637.

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Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) cause intestinal discomfort in patients with irritable bowel syndrome (IBS). An enzyme mix (2500 SU invertase, 2400 GalU α-galactosidase, 10,000 ALU β-galactosidase) optimized for FODMAP digestion, and/or human milk oligosaccharides (HMO) (2′-FL, DFL, and LNnT), were evaluated for effects on microbial community activity and composition in short-term colonic incubations using the fecal microbiota of four patients with IBS-D symptoms under the following test conditions: (i) FODMAP, (ii) pre-digested (with enzyme

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Liu, Yafei, Ajila Chandran Matheyambath, Ives Ivusic Polic, and Gisèle LaPointe. "Differential fermentation of raw and processed high-amylose and waxy maize starches in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®)." Journal of Functional Foods 86 (November 2021): 104735. http://dx.doi.org/10.1016/j.jff.2021.104735.

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Cárdenas-Castro, Alicia Paulina, Fernanda Bianchi, María Angela Tallarico-Adorno, Efigenia Montalvo-González, Sonia G. Sáyago-Ayerdi, and Katia Sivieri. "In vitro colonic fermentation of Mexican “taco” from corn-tortilla and black beans in a Simulator of Human Microbial Ecosystem (SHIME®) system." Food Research International 118 (April 2019): 81–88. http://dx.doi.org/10.1016/j.foodres.2018.05.072.

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Sapp, Philip A., Jeremy R. Townsend, Trevor O. Kirby, et al. "AG1®, a Novel Synbiotic, Demonstrates Superior Mineral Bioaccessibility and Bioavailability Compared to a Tablet Multivitamin and Mineral Supplement Using an In Vitro Model of the Upper Gastrointestinal Tract." Applied Biosciences 2, no. 4 (2023): 656–67. http://dx.doi.org/10.3390/applbiosci2040041.

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While traditional multivitamin and mineral (MVM) supplements generally come in tablet form, new powder forms of MVM supplements are available with theoretically higher bioavailability relative to tablet MVM supplements. The purpose of this study was to assess the bioaccessibility and bioavailability of minerals (magnesium (Mg), zinc (Zn), calcium (Ca), and potassium (K)) in a tablet MVM supplement compared to a novel powder Foundational Nutrition supplement (AG1®), containing minerals, vitamins, phytochemicals, and pre-/probiotics, in the upper gastrointestinal tract. The tablet MVM supplement

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Marzorati, Massimo, Bingcai Qin, Falk Hildebrand, et al. "Addition of acacia gum to a FOS/inulin blend improves its fermentation profile in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®)." Journal of Functional Foods 16 (June 2015): 211–22. http://dx.doi.org/10.1016/j.jff.2015.04.039.

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Van den Abbeele, Pieter, Jonas Ghyselinck, Massimo Marzorati, et al. "In Vitro Evaluation of Prebiotic Properties of a Commercial Artichoke Inflorescence Extract Revealed Bifidogenic Effects." Nutrients 12, no. 6 (2020): 1552. http://dx.doi.org/10.3390/nu12061552.

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Background: Prebiotics used as a dietary supplement, stimulate health-related gut microbiota (e.g., bifidobacteria, lactobacilli, etc.). This study evaluated potential prebiotic effects of an artichoke aqueous dry extract (AADE) using in vitro gut model based on the Simulator of Human Intestinal Microbial Ecosystem (SHIME®). Methods: Short-term colonic fermentations (48 h) of AADE, fructo-oligosaccharides (FOS), and a blank were performed. Microbial metabolites were assessed at 0, 6, 24, and 48 h of colonic incubation via measuring pH, gas pressure, lactate, ammonium, and short-chain fatty aci

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Šuligoj, Tanja, Louise Kristine Vigsnæs, Pieter Van den Abbeele, et al. "Effects of Human Milk Oligosaccharides on the Adult Gut Microbiota and Barrier Function." Nutrients 12, no. 9 (2020): 2808. http://dx.doi.org/10.3390/nu12092808.

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Human milk oligosaccharides (HMOs) shape the gut microbiota in infants by selectively stimulating the growth of bifidobacteria. Here, we investigated the impact of HMOs on adult gut microbiota and gut barrier function using the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®), Caco2 cell lines, and human intestinal gut organoid-on-chips. We showed that fermentation of 2’-O-fucosyllactose (2’FL), lacto-N-neotetraose (LNnT), and combinations thereof (MIX) led to an increase of bifidobacteria, accompanied by an increase of short chain fatty acid (SCFA), in particular butyrate with 2

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Van den Abbeele, Pieter, Cindy Duysburgh, Ilse Cleenwerck, Ruud Albers, Massimo Marzorati, and Annick Mercenier. "Consistent Prebiotic Effects of Carrot RG-I on the Gut Microbiota of Four Human Adult Donors in the SHIME® Model despite Baseline Individual Variability." Microorganisms 9, no. 10 (2021): 2142. http://dx.doi.org/10.3390/microorganisms9102142.

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The human gut microbiome is currently recognized to play a vital role in human biology and development, with diet as a major modulator. Therefore, novel indigestible polysaccharides that confer a health benefit upon their fermentation by the microbiome are under investigation. Based on the recently demonstrated prebiotic potential of a carrot-derived pectin extract enriched for rhamnogalacturonan I (cRG-I), the current study aimed to assess the impact of cRG-I upon repeated administration using the M-SHIME technology (3 weeks at 3g cRG-I/d). Consistent effects across four simulated adult donor

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Rovalino-Córdova, Ana M., Vincenzo Fogliano, and Edoardo Capuano. "Effect of bean structure on microbiota utilization of plant nutrients: An in-vitro study using the simulator of the human intestinal microbial ecosystem (SHIME®)." Journal of Functional Foods 73 (October 2020): 104087. http://dx.doi.org/10.1016/j.jff.2020.104087.

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Vance, Arianne, Shilpa Raut, Adeline Grier-Welch, Nima Alamdari, and Mastaneh Sharafi. "Survival and Release Behavior of a Novel Pre-, Pro-, and Postbiotic Capsule in an In Vitro SHIME Model." Current Developments in Nutrition 6, Supplement_1 (2022): 539. http://dx.doi.org/10.1093/cdn/nzac077.042.

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Abstract Objectives To test the survival and release of probiotics (Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis BB-12), a prebiotic (bacteriophage blend), and a postbiotic (tributyrin) in a capsule-within-capsule design during passage through the gastrointestinal tract under fed and fasted conditions. Methods Using an adapted Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) model, physiological conditions of the stomach and small intestine, including pH profiles, temperature, incubation time, and addition of bile liquid and digestive enzymes, were simula

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Marcobal, Angela M., Bruce R. McConnell, Riley A. Drexler та ін. "Highly Soluble β-Glucan Fiber Modulates Mechanisms of Blood Glucose Regulation and Intestinal Permeability". Nutrients 16, № 14 (2024): 2240. http://dx.doi.org/10.3390/nu16142240.

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β-glucans found in cereal grains have been previously demonstrated to improve blood glucose control; however, current understanding points to their high viscosity as the primary mechanism of action. In this work, we present a novel, highly soluble, low-viscosity β-glucan fiber (HS-BG fiber) and a preclinical dataset that demonstrates its impact on two mechanisms related to the prevention of hyperglycemia. Our results show that HS-BG inhibits the activity of two key proteins involved in glucose metabolism, the α-glucosidase enzyme and the SGLT1 transporter, thereby having the potential to slow

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Govaert, Marlies, Chloë Rotsaert, Chelsea Vannieuwenhuyse, et al. "Survival of Probiotic Bacterial Cells in the Upper Gastrointestinal Tract and the Effect of the Surviving Population on the Colonic Microbial Community Activity and Composition." Nutrients 16, no. 16 (2024): 2791. http://dx.doi.org/10.3390/nu16162791.

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Many health-promoting effects have been attributed to the intake of probiotic cells. However, it is important that probiotic cells arrive at the site of their activity in a viable state in order to exert their beneficial effects. Careful selection of the appropriate probiotic formulation is therefore required as mainly the type of probiotic species/strain and the administration strategy may affect survival of the probiotic cells during the upper gastrointestinal (GIT) passage. Therefore, the current study implemented Simulator of the Human Microbial Ecosystem (SHIME®) technology to investigate

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