Academic literature on the topic 'Shiro (Dog)'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Shiro (Dog).'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Journal articles on the topic "Shiro (Dog)"
1
노영숙. "Akutagawa Ryunosuke' A dog named ‘Shiro(White)’." Japanese Language and Literature Association of Daehan ll, no. 54 (May 2012): 247–63. http://dx.doi.org/10.18631/jalali.2012..54.014.
Full text
2
Katagiri, Hiroki, Hideyuki Koga, and Takeshi Muneta. "Review of Shino et al (1984) on anterior cruciate ligament reconstruction using allograft in the dog." Journal of ISAKOS: Joint Disorders & Orthopaedic Sports Medicine 3, no. 3 (December 7, 2017): 186–92. http://dx.doi.org/10.1136/jisakos-2017-000131.
Full textAbstract:
This article discusses the original1984 publication of ‘Replacement of the anterior cruciate ligament using an allogeneic tendon graft. An experimental study in the dog’. The original classic study discovered the revascularisation and remodelling of an allograft for anterior cruciate ligament reconstruction (ACLR) using microangiographic, histological and biomechanical methods. The original classic study suggested that a transplanted allogeneic tendon can substitute for an autograft in ACLR. The original classic study suggested this new option to the orthopaedic medical community. Currently, an allograft is one of the main alternatives used for ACLR. This article begins with a detailed summary of the original classic study. Second, this article reviews the historical perspectives, the scientific and societal effect and the effect of the original classic study on present practices. Finally, the ultimate goal of this article is to validate the use of allogeneic tendon grafts in ACLR with the current evidence of clinical studies and animal experiments and to elucidate any remaining questions regarding allogeneic tendon grafts, which could then be resolved through studies in the near future.
3
Aldridge, Meryl, and Christopher J. Brotherton. "Being a Programme Authority: Is it Worthwhile?" Journal of Social Policy 16, no. 3 (July 1987): 349–69. http://dx.doi.org/10.1017/s0047279400015944.
Full textAbstract:
ABSTRACTNottingham is one of 23 local authorities designated as ‘programme authorities’ under the Inner Urban Areas Act 1978. Between 1983 and 1985 the authors carried out research into the formulation of inner city policy, its application to the Radford area in particular and the opinions of residents there about its impact. Interviews with a wide range of those involved with policy including local authority officers and members and representatives of the police, the health authority and regional Department of the Environment (DoE) revealed considerable institutional and political barriers to a joint inner city strategy in a shire district, even where the same party holds political control. Structures set up to liaise are cordial but clumsy, slow and very much removed from daily service delivery. As elsewhere, the local authorities are critical of lack of central government commitment to this part of the Urban Programme, but nevertheless work well with regional DoE. Paradoxically, however, despite their criticisms of a lack of central funds and of inappropriate spatial and other parameters, the local authority and health authority respondents are anxious for the Programme to continue as it provides both the resources and the justification for innovatory and redistributive projects which would otherwise have been financially and politically impossible.
4
Crudele, Julie M., Jonathan D. Finn, Nicholas B. Martin, Joshua I. Siner, Yifeng Chen, Shangzhen Zhou, Glenn Niemeyer, et al. "Tolerance Induction To FIX Padua With AAV Liver Gene Transfer In Inhibitor-Prone Hemophilia B Dogs." Blood 122, no. 21 (November 15, 2013): 4203. http://dx.doi.org/10.1182/blood.v122.21.4203.4203.
Full textAbstract:
Abstract Emerging data from early phase clinical studies of AAV gene therapy for hemophilia B (HB) (factor IX [FIX] deficiency) show sustained expression of therapeutic levels of FIX and phenotypic improvement. However, the safety and efficacy of in vivo gene therapy is limited by the vector dose. Recently, we reported a naturally occurring, hyperfunctional FIX (FIX Padua) caused by a single amino acid change of arginine 338 to leucine that exhibits an 8-fold increase in specific activity in humans (N Engl J Med 2009), making it a potential candidate for HB gene therapy with reduced vector doses. However, to take advantage of FIX Padua for HB gene therapy, it is critical to first define the risk of immunogenicity of this variant in preclinical models of severe HB. We have previously shown that delivery of AAV-cFIX-Padua to skeletal muscle in HB dogs with a missense mutation in the canine (c) F9 gene resulted in no anti-FIX neutralizing antibodies (inhibitors), non-neutralizing antibodies (IgG) or FIX-specific T-cell response (Blood 2012). While promising, these dogs express FIX RNA and have a pre-existing tolerance to cFIX due to the nature of their mutation, and so do not represent the most rigorous model for immunogenicity studies. Here, we tested the efficacy and immunogenicity of cFIX Padua in a severe HB dog colony with an early stop codon mutation. This mutation results in no FIX RNA transcript, and the dogs are prone to develop cFIX inhibitors upon exposure to protein concentrates. Three dogs were infused peripherally with a liver-specific AAV8-cFIX-Padua at two different doses, and monitored for cFIX antigen and activity levels and inhibitors. The first dog, which received 3 x 1012 vg/kg, showed average plateaued expression levels of 3.98 ± 1.44% antigen and 24.5 ± 4.1% activity, with no development of anti-cFIX inhibitors or IgG antibodies. Whole blood clotting time (WBCT) and aPTTs returned to normal by day 3 post-vector administration and have remained stable for >20 months (ongoing observations). A second dog was treated with a lower dose of 1 x 1012 vg/kg and showed average plateaued expression levels of 2.41 ± 0.05% antigen and 22.0 ± 0.4% activity, with no development of anti-cFIX inhibitors or IgG antibodies. WBCT and aPTTs returned to normal by day 3 post-vector administration and have remained stable for >3 months. An additional dog, upon previous exposure to recombinant human (h) FIX protein, had developed inhibitors that cross-reacted with cFIX. This immune response was ongoing at the time of vector administration (3 x 1012 vg/kg). Anti-cFIX antibodies peaked at day 14 post-AAV, with 4.7 BUs and 3643 ng/mL IgG2, but dropped to undetectable levels by day 70. There was a concurrent rise in cFIX Padua expression levels, suggesting successful tolerization to the cFIX Padua. Antigen levels plateaued at 14.6 ± 4.3% and activity at 51.7 ± 23.5%, with ongoing normalization of WBCT and aPTTs for >18 months. In all three dogs, cholesterol, albumin and total protein were within normal limits with no clinical or laboratory evidence of nephrotic syndrome (a potential complication in FIX inhibitor patients that have undergone immune tolerance induction with frequent FIX protein injections). The safety of FIX Padua was further confirmed using a mouse model of HB. Mice (n=8-12/group) were treated with 5 x 1010 vg/kg liver-directed AAV8-hFIX-WT or AAV8-hFIX-Padua, resulting in expression levels of 1076 ± 343 ng/mL (21.5 ± 6.9% antigen, 67.5 ± 10.1% activity) and 797 ± 255 ng/mL (15.9 ± 5.1% antigen, 274.8 ± 73.8% activity), respectively. In cross-over experiments, the mice were then were immunologically challenged 10-15 weeks after gene delivery with 100 ug/kg of the reciprocal recombinant protein (ie mice expressing hFIX Padua were challenged with hFIX WT, and visa versa). Challenges were administered subcutaneously alone or with adjuvant (CFA) weekly for 4 weeks. In no instance did mice develop antibodies to either FIX, suggesting that tolerance was successfully induced in all cases. Together, these date show that FIX Padua shows no increase in immunogenicity compared to FIX WT and is capable not only of preventing inhibitor formation, but also of eradicating pre-existing inhibitory antibodies to FIX in an inhibitor-prone HB dog model. Thus, FIX Padua is an attractive transgene that will allow for decreased vector doses in human HB gene therapy, improving the safety profile of AAV liver gene therapy without increased immunogenicity. Disclosures: High: Alnylam Pharmaceuticals: Consultancy; BioMarin: Consultancy; bluebirdbio, Inc.: Consultancy, Equity Ownership, Membership on an entity’s Board of Directors or advisory committees; BristolMyersSquibb: Consultancy, membership on a Data Safety and Monitoring Board, membership on a Data Safety and Monitoring Board Other; Elsevier, Inc.: royalties from textbook, royalties from textbook Patents & Royalties; Genzyme, Inc.: Membership on an entity’s Board of Directors or advisory committees; Intrexon: Consultancy; Novo Nordisk: Consultancy, Member of a grant review committee, Member of a grant review committee Other; Shire : Consultancy; Benitec: Consultancy.
5
Cooke, Esther J., Srila Gopal, John Shimashita, Chanond A. Nasamran, Kathleen M. Fisch, Laurent O. Mosnier, and Annette von Drygalski. "Systemic Transcriptional Responses to Hemarthrosis and FVIII Replacement in FVIII-Deficient Mice." Blood 132, Supplement 1 (November 29, 2018): 381. http://dx.doi.org/10.1182/blood-2018-99-120092.
Full textAbstract:
Abstract Introduction Hemarthrosis in patients with hemophilia (PWH) leads to local inflammation and vascular changes in the joint, but little is known about the extent and nature of systemic responses to joint bleeding. Since the spleen is a major systemic immune-modulatory organ, we quantified changes in splenic gene expression profiles in FVIII-deficient mice at baseline and after induced hemarthrosis, and in the presence and absence of FVIII replacement therapy. Methods Hemarthrosis was induced in FVIII-deficient mice by sub-patellar needle puncture +/- 100 IU/kg recombinant human FVIII (rhFVIII) intravenously 2 hours before and 6 hours after injury. Spleens were harvested on day 3 or 2 weeks post-injury (n=3-5). Spleens from uninjured mice +/- rhFVIII treatment served as controls. RNA libraries were prepared using the NEBNext Ultra II Directional RNA Library Prep Kit and sequenced on an Illumina NextSeq500 platform (single-end; 75bp reads). The limma-voom method (R Bioconductor) was used for differential expression analyses. The criteria for differential expression were: i) a log fold-change (logFC) >1 or <-1, and ii) an adjusted p value <0.05. Functional enrichment was performed using Signaling Pathway Impact Analysis and the STRING database of protein-protein interactions. Results Knee injury in FVIII-deficient mice caused gross hemarthrosis that was largely prevented with rhFVIII prophylaxis (day 2 hematocrit: 26.4% and 46.3%). Pronounced alterations in splenic gene expression profiles occurred in vehicle-treated mice on day 3 post-injury, with 4227 differentially expressed genes (DEG) and 41 perturbed pathways. This response was markedly improved with rhFVIII treatment (386 DEG; 5 pathways), and almost entirely corrected by 2 weeks. Multiple pathways relating to immune processes, inflammation, and cell survival were highly perturbed on day 3 post-injury, including cytokine-cytokine receptor interactions (pNDE=1.4x10-6) and cell cycle (pNDE=5.3x10-5). The cell cycle pathway remained significantly altered despite rhFVIII treatment (pNDE=3.5x10-6), while other pathways were comparable to uninjured mice. Analysis of the top 50 DEG that are mutual to both treatment groups revealed a striking difference in directionality, with up-regulation in the vehicle group, and down-regulation in the rhFVIII group. Together, these findings demonstrate a significant effect of rhFVIII treatment on systemic transcriptional responses to joint bleeding. Treatment with rhFVIII in the absence of hemarthrosis resulted in only 97 DEG on day 3 by the same criteria, and 233 DEG after lowering the logFC threshold from (-)1 to (-)0.5. Of these 233 genes, STRING analysis revealed perturbation of the platelet activation pathway (FDR: 7.7x10-10) for up-regulated genes (93 DEG) and the T cell receptor signaling pathway (FDR: 1.3x10-8) for down-regulated genes (140 DEG), which may corroborate a role of T cell responses to rhFVIII treatment in the development of inhibitors. These responses to rhFVIII were unique to uninjured mice and did not occur in mice with induced hemarthrosis and rhFVIII treatment. Conclusions Joint bleeding in hemophilic mice leads to acute, profound changes in multiple systemic pathways, including immune and inflammatory processes, as shown by gene expression profiling. Prophylactic treatment with rhFVIII largely corrects this response to hemarthrosis. Interestingly, in the absence of hemarthrosis, rhFVIII treatment affects platelet activation and T cell receptor signaling, whereby further analyses are required to determine if these effects stimulate or dampen immune responses. This approach can be used to explore the systemic mechanisms contributing to progressive hemophilic arthropathy in PWH, elucidate immune responses that may facilitate inhibitor formation, and lead to development of novel therapeutic strategies. Disclosures von Drygalski: UniQure BV, Bayer, Bioverativ/Sanofi, Pfizer, Novo Nordisk, Biomarin, Shire, CSL Behring: Consultancy.
6
Dufty, AC. "Population demography of the eastern barred bandicoot (Perameles gunnii) at Hamilton, Victoria." Wildlife Research 21, no. 4 (1994): 445. http://dx.doi.org/10.1071/wr9940445.
Full textAbstract:
Totals of 32 female and 53 male Perameles gunnii were caught 241 and 330 times, respectively, during 4340 trap-nights at Hamilton, Victoria. Residents comprised 75.3% (n = 64) of the sample. Morphometric comparison indicates that P. gunnii is sexually dimorphic. Sex ratios (expressed in percentage of females) of 55% (dependent juvenile), 45% (independent juvenile) and 37.9% (adult) were determined. The age structure of the live-trapped population changed substantially between July 1989 (42.9% juvenile, 9.5% subadult and 47.6% adult) and August 1990 (46.2% juvenile, 15.4% subadult and 34.6% adult). The mean age of captured female bandicoots increased during the study, from 9.8 months in July 1989 to 15.8 months in August 1990. In all, 24 of 32 females produced 145 pouch young in 66 litters, with a mean W e . ) litter size of 2.2+/-0.1 (n = 66). The number of females that were lactating each month was high throughout the study (85%) and peaked during spring and autumn when all captured females were lactating. Sexual maturity for males and females occurred at about 5 and 3.5 months of age, respectively. The causes of mortality of P. gunnii between 1980 and 1990 included road death (63%, n = 85), cat predation (17.8%, n = 24), disease (8.1%, n = 11), trap death (5.2%, n = 7), machinery (3.7%, n = 5) and dog predation (2.2%, n = 3). A total of 25 P. gunnii died from unknown causes. Cat predation of P. gunnii may be high amongst juveniles and subadults but low for adults. A net emigration rate of 18% of individuals known to be alive indicates that the Hamilton Municipal Tip is a source for dispersal to other subpopulations. The 1990 distribution of the population was about 169 ha, within the City of Hamilton and adjacent Shire of Dundas, Victoria. There has been a decline in distribution and some local extinctions of P. gunnii in several areas between 1988 and 1990.
7
Gonzalez, C., L. A. Menchén Viso, O. Baniandrés Rodríguez, I. Marín-Jiménez, J. C. Nieto, I. Monteagudo, A. Ais Larisgoitia, et al. "SAT0607-HPR MULTIDISCIPLINARY CARE CLINIC FOR PATIENTS WITH IMMUNITY MEDIATED INFLAMMATORY DISEASES. FIRST YEAR OF COORDINATED MANAGEMENT." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1263.1–1264. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2997.
Full textAbstract:
Background:Patients with immunity mediated inflammatory diseases (IMID) often have clinical manifestations and comorbidity in the field of various medical specialties. A center has been created in our hospital for the comprehensive care of patients with IMID who are being treated with biological therapies (BT) or targeted synthetic molecules (TSM). It is an innovative healthcare model, that incorporate patients into its governance. Physicians, pharmacists and advanced practice nurses (APN), collaborates in consultation or in the day hospital (DH).Objectives:To analyze the activity developed during the first year of operation of the center, with special attention to effectiveness, efficiency, interdisciplinary relationships and patient satisfaction.Methods:Observational analysis with indicators of management and monitoring of patients, care activity, effectiveness, adverse effects, resource consumption and patient satisfaction using the hospital’s own information systems.Results:Center staff during 2019: two admission assistants, one nursing assistant, six nurses, seven part-time doctors and three pharmacists. 1,490 patients were included: 694 (46.6%) Rheumatology (Rheu), 585 (39.3%) Digestive (Dig) and 211 (14.1%) Dermatology (Der) generated 11,363 medical consultations, 14,850 APN consultations and 3,920 treatment sessions in the DH. IV treatment 529/1490 (35.5%) patients (45.0% Reu, 53.9% Dig, 1.1% Der). Patients with rheumatic diseases: rheumatoid arthritis: 339/694, 48.8%; Spondyloarthritis: 226/694, 32.6%; psoriatic arthritis: 117/694, 16.9%; and juvenile idiopathic arthritis: 12/694, 1.7%. 217/1490 (14.6%) patients needed multidisciplinary consultations.Table 1. shows the most relevant indicators and table 2 shows the patient satisfaction survey for 2019.Table 1.relevant indicatorsRHEUDIGDEROn demand consultations 2019 %21.0%34.2%14.3%Teleconsultations 2019 %17.8%41.9%0.0%BT, TSM tapering. %201931.9%0.2%45,5%201818.9%0.2%13.4%BT, TSM intensification. %20195.8%35.2%0.5%20182.6%36.5%0.5%Biosimilars %201943.1%48.5%15.9%201830.4%4.0%12.1%Adherence>90% 2019 %89.4%91.7%86.4%Remission 2019 %47.8%67.3%78.5%hospital admission, any cause pat-years20191.41.70.120181.51.50.04emergency admission, any cause pat-years20192.12.11.620182.12.01.5Table 2.patient satisfaction surveyCategoríaMean and (DS) 1-5General aspects of the center4.3 (0.9)Physicians4.5 (1.1)DH and APN4.5 (1.2)Pharmacy4.6 (0.9)Health proffesional coordinaton4.4 (0.9)Hospital global satisfaction4.3 (0.8)Conclusion:From previous situation there is an increase in interdisciplinary consultations and HD activity maintenance without an increase in human resources. Efficiency (tapering, biosimilars) and patient and staff satisfaction have improved. However, no improvement in adverse effects has been observed, which is an area of improvement. Effectiveness is good, waiting to compare with the previous year. Nutrition and preventive medicine consultations has not been evaluated because have been recently established. Other indicators are being analyzed at the end of the submission deadline.The impact of this pioneering management model, with a holistic approach and incorporating patients into its governance, is difficult to measure until its implementation is completed. Uveitis and psychology consultations and patient school starting in 2020 will improve the quality of IMID patient care, as well as their satisfaction and that of their relatives.Disclosure of Interests:Carlos Gonzalez Consultant of: Gilead, Janssen, Novartis,, Speakers bureau: Abbvie, Celgene, Gilead, Janssen, Novartis, Pfizer, Roche, Luis Alberto Menchén Viso Grant/research support from: Abbvie, Janssen, MSD, Takeda, Consultant of: Abbvie, Janssen, Takeda, MSD, Medtronic, Tillotts, Pfizer, Dr. Falk Pharma, Speakers bureau: Abbvie, Janssen, Takeda, MSD, General Electric, Tillotts, Pfizer, Ferring, General Electric, Fresenius, Ofelia Baniandrés Rodríguez: None declared, Ignacio Marín-Jiménez Consultant of: AbbVie,Chiesi,FAES Farma,Falk-Pharma,Ferring,Gebro Pharma, Hospira,Janssen,MSD,Otsuka Pharmaceutical,Pfizer,Shire,Takeda,Tillots and UCB Pharma, Speakers bureau: AbbVie,Chiesi,FAES Farma,FalkPharma,Ferring,Gebro Pharma,Hospira,Janssen,MSD,Otsuka Pharmaceutical,Pfizer,Shire,Takeda,Tillots and UCB Pharma, Juan Carlos Nieto Speakers bureau: Pfizer, Abbvie, MSD, Novartis, Janssen, Lilly, Nordic Pharma, BMS, Gebro, FAES Farma, Roche, Sanofi, Indalecio Monteagudo: None declared, Arantza Ais Larisgoitia: None declared, Esther Chamorro de Vega: None declared, Elena Lobato Matilla: None declared, Rosa Romero Jiménez: None declared, Ana Herranz Alonso: None declared, Carmen Lobo Rodríguez: None declared, María Prado Simón Moreno: None declared, Jose-Maria Alvaro-Gracia Grant/research support from: Abbvie, Elli-Lilly, MSD, Novartis, Pfizer, Consultant of: Abbvie, BMS, Janssen-Cilag, Elli-Lilly, MSD, Novartis, Pfizer, Sanofi, Tigenix, Roche, UCB, Paid instructor for: Elli-Lilly, Pfizer, Roche, Speakers bureau: Abbvie, BMS, Janssen-Cilag, Elli-Lilly, Gedeon Richter, MSD, Novartis, Pfizer, Sanofi, Tigenix, Roche, UCB, Sonia García de San José: None declared
8
Bush, Adam M., Matthew Borzage, Thomas Coates, and John C. Wood. "Cerebral Blood Flow and Oxygen Delivery In Response To Hyperoxia In Sickle Cell Anemia." Blood 122, no. 21 (November 15, 2013): 2210. http://dx.doi.org/10.1182/blood.v122.21.2210.2210.
Full textAbstract:
Abstract Neurovascular sequalae are a common occurrence in Sickle Cell Anemia (SCA), with 11% of patients suffering cerebral vascular accident (CVA), or overt stroke by their twentieth birthday and 40% of patients developing silent cerebral infarcts (SCI) by age 14. Elevated transcranial Doppler (TCD) velocity of the middle cerebral artery identifies patients at risk for stroke, and this risk can be reduced by chronic transfusion therapy. However, the specificity of TCD is low causing many patients to be transfused unnecessarily. To further refine cerebrovascular risk stratification, we are studying factors responsible for normal and pathophysiologic cerebral blood flow (CBF) in SCD patients. Cerebral blood flow is increased in SCA patients compared to controls, but is believed to be a compensatory mechanism for chronic anemia and systemic desaturation. In order to test this hypothesis, we studied whole CBF and oxygen delivery (DO2) at rest and in response to hyperoxia in subjects with SCA and sickle cell trait (SCT). All patients were recruited at Children's Hospital Los Angeles through an IRB approved protocol. Informed consent was obtained for all patients. Exclusion criteria included pregnancy, previous stroke, acute chest or pain crisis hospitalization within one month. EKG, peripheral arterial oxygen saturation (SaO2), and fractional inspired oxygen (fiO2) were measured continuously throughout the study. Imaging consisted of a survey, reference scan, angiography localization, and nine axial phase contrast (PC) images. PC slices were placed inferior to the Circle of Willis, perpendicular to the carotids and basilar arteries. Participants received room air and 100% O2 through a non rebreathing respiratory circuit at 10 L/m. Room air exposure 20 minutes with six PC images collected throughout. Oxygen was delivered for 5 minutes followed by three more PC images. Blood for hemoglobin (HGB) and hematocrit (HCT) were drawn prior to MRI testing. No adverse events were reported upon follow up. Nine patients with SCA (5 male, 22.5 ± 6.7 yo p<0.05) and 3 with sickle cell trait (2 male, 36.7 ± 8.7 yo p<0.05) were studied. Baseline HGB was 25% lower (9.7 ± 1.3 versus 12.9 ± 0.1) and baseline HCT was 41% lower (28.0 ± 3.6 versus 47.3 ± 0.14 SCT) in SCA patients (p<0.05). Baseline whole brain CBF was elevated in SCA (1398 ± 400 ml/min versus 700 ± 172 ml/min). After correcting for HGB and SaO2, DO2 remained higher in SCA (192 ± 75 ml/min versus 105 ± 1.4 ml/min, p<0.05). During hyperoxia, whole brain CBF decreased by 10-15%, but the change was proportional to increased oxygen carrying capacity such that there was no change in DO2 in either populations. The increase in CBF we observed in SCA patients has been described using other modalities. However, we are the first to demonstrate that the increased flow observed is almost double what can be explained by their anemia and arterial desaturation alone. There are several possibilities for this observation. 1) SCA patients could have increased cerebral metabolic rate. If so, their mixed cerebral venous saturation will be normal and the flow is appropriate; 2) SCA patients have a mismatch between cerebral perfusion and metabolic demand, whether much of the increased flow does not effectively unload oxygen. If so, cerebral venous saturation would be high. We are currently optimizing MRI and NIR's technologies to estimate cerebrovascular metabolic rate, mixed cerebral venous saturation, and local supply-demand balance. Figure 1 Baseline CBF and O2 delivery in SCA and control group. ** statically significant population difference Figure 1. Baseline CBF and O2 delivery in SCA and control group. ** statically significant population difference Figure 2 Responce to 100% oxygen exposure. *statistically significant change from baseline Figure 2. Responce to 100% oxygen exposure. *statistically significant change from baseline Disclosures: Coates: Novartis Inc.: Honoraria, Speakers Bureau; Apopharma: Honoraria, Speakers Bureau; Shire: Speakers Bureau. Wood:Shire: Consultancy, Research Funding; Apopharma: Honoraria, Patents & Royalties; Novartis: Honoraria.
9
Cooke, Esther J., Jenny Y. Zhou, Tine Wyseure, Srila Gopal, John Shimashita, Chanond A. Nasamran, Kathleen M. Fisch, Laurent O. Mosnier, and Annette von Drygalski. "Effects of Hemostasis Correction on Vascular Remodeling and Synovial Gene Expression Changes in Mice after Induced Hemarthrosis." Blood 132, Supplement 1 (November 29, 2018): 1188. http://dx.doi.org/10.1182/blood-2018-99-119694.
Full textAbstract:
Abstract Introduction Repeated joint bleeding in patients with hemophilia leads to hemophilic arthropathy (HA), which cannot be entirely prevented by clotting factor replacement. Vascular remodeling and permeability are associated with hemarthrosis and may contribute to HA progression; however, the mechanisms and effects of hemostasis correction are poorly understood. Here, we explored synovial vascular and gene expression changes in FVIII-deficient mice after induced hemarthrosis +/- FVIII replacement, and in wild-type mice with reversible hemostasis suppression. Methods Hemarthrosis was induced in FVIII-deficient mice by sub-patellar needle puncture +/- 100-200 IU/kg recombinant human FVIII (rhFVIII) 2 hours before and 6 hours after injury. Wild-type mice were treated with 10 µg/ml warfarin for 7 days and 0.25 mg/kg anti-FVIII 2 hours before injury (hypoBALB/c). After injury, warfarin was continued for 2 weeks or reversed on day 2 with 100 IU/kg 4-factor prothrombinase complex concentrate (4F-PCC). Vascularity and gene expression were analyzed at baseline and 2 weeks post-injury. Vessel number and remodeling were assessed by histology with Safranin-O-Fast Green and α-smooth muscle actin (αSMA) staining, respectively, and microvascular flow was detected by musculoskeletal ultrasound with Power Doppler. The permeability of synovial vessels was determined by quantification of extravasated albumin-bound Evans blue dye in knee joints. For synovial gene expression studies, libraries were prepared using the NEBNext Ultra II DNA Library Prep Kit and sequenced on an Illumina NextSeq500 (single-end; 75bp reads). The limma-voom method (R BioConductor) was used for differential expression analyses and functional enrichment was performed using Signaling Pathway Impact Analysis. Results In FVIII-deficient mice, knee injury caused profound hemarthrosis that was largely prevented with rhFVIII prophylaxis (day 2 hematocrit: 26.4% and 46.3%). Soft tissue proliferation increased to a similar extent, as did various vascular parameters: microvascular flow (vehicle: 1.8-fold; rhFVIII: 1.5-fold), vessel number (vehicle: 2.3-fold, p=0.0005; rhFVIII: 2.0-fold, p=0.004), vessels with diameter ≥ 20 µm (vehicle: 2.9-fold, p=0.02; rhFVIII: 2.7-fold, p=0.02), and αSMA area per vessel (vehicle: 2.3-fold, p>0.05; rhFVIII: 3.6-fold, p=0.0006). Vascular permeability also increased significantly (1.7-fold, p=0.0007) and was only partially rescued by rhFVIII prophylaxis (1.3-fold, p>0.05). In hypoBALB/c mice (day 2 hematocrit: 29.6%), significant but less pronounced vascular changes occurred regardless of hemostasis correction, and without associated permeability, suggesting this is uniquely associated with FVIII-deficiency. RNA sequencing in FVIII-deficient mice revealed a strong transcriptional response to hemarthrosis (1527 differentially expressed genes (DEG), 13 perturbed pathways) that was only partially dampened with rhFVIII treatment (891 DEG, 20 pathways). Perturbation of extracellular matrix (ECM)-receptor interactions was highly significant in both groups (vehicle: pNDE=7.7x10-10; rhFVIII: pNDE=6.8x10-9). Similarly, numerous genes relating to angiogenesis and ECM remodeling, including collagens and MMPs, were up-regulated and minimally affected by rhFVIII treatment. These transcriptional changes may facilitate the observed vascular remodeling after hemarthrosis. Conclusions Hemarthrosis triggers profound changes in synovial gene expression, notably ECM components, that may drive the associated soft tissue and vascular changes, including vessel remodeling and leakiness. These processes are incompletely mitigated by hemostasis correction and may exacerbate (re-) bleeding tendencies. Therefore, further exploration is needed to identify key molecular pathways that can be targeted to intercept the progression of HA. Disclosures von Drygalski: UniQure BV, Bayer, Bioverativ/Sanofi, Pfizer, Novo Nordisk, Biomarin, Shire, CSL Behring: Consultancy.
10
Bush, Adam M., Matthew Borzage, Thomas Coates, John C. Wood, and Soyoung Choi. "Cerebral Blood Flow and Metabolic Correlates of Near Infrared Spectroscopy in Patients with Sickle Cell Disease." Blood 124, no. 21 (December 6, 2014): 1386. http://dx.doi.org/10.1182/blood.v124.21.1386.1386.
Full textAbstract:
Abstract Introduction Tissue oxygen index (TOI), by near Infrared Spectroscopy (NIRS), is a valuable tool for noninvasive, indirect measurement of oxygen supply-demand balance. Cerebral TOI is decreased in sickle cell disease (SCD), and correlates with disease severity. Previous work suggests that cerebral TOI is inversely correlated with hemoglobin S level and chronic transfusion therapy restores TOI to normal values. Nahavandi et al. have proposed that low cerebral TOI in SCD disease can be attributed to impaired oxygen delivery and/or carrying capacity of sickle blood. Unfortunately, the specificity of cerebral TOI is still an area of active debate. In order to elucidate these mechanisms we measured global cerebral blood flow (CBF),arterial oxygen content (CaO2), oxygen delivery (DO2), arterial and venous oxygen saturation (SaO2 and SvO2) and oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) in 12 healthy controls and 15 SCD patients using magnetic resonance imaging (MRI). Methods All patients were recruited with informed consent or assent and this study was approved by the CHLA IRB. Fifteen patients with SCD and 12 healthy ethnicity matched controls (CTL) were studied. MRI compatible NIRS probes were placed on the forehead and TOI was recorded throughout the entire MRI examination. SaO2 was measured via peripheral pulse oximetery. Phase Contrast (PC) of the carotid and vertebral arteries was used to measure global CBF. T2 Relaxation Under Spin Tagging (TRUST) was used to measured T2 relaxation of blood within the sagittal sinus. T2 relaxation was converted to SvO2 via calibration curves. Blood draw for hemoglobin and electrophoresis was performed. Exclusion criteria included pregnancy, previous stroke, acute chest or pain crisis hospitalization within one month. Results Table 1 summarizes the relationship between cerebral TOI, age, laboratory values, and hemodynamic variables. Surprisingly, TOI was independent of indices of oxygen supply (SaO2, CBF, oxygen delivery) and oxygen demand (CMRO2); cerebral venous saturation and OEF were the only hemodynamic correlate of TOI. Total hemoglobin and percent sickle hemoglobin were equally and independently correlated with TOI with a combined r2 of 0.59 on multivariate regression (p<0.0001). Discussion This represents the first study comparing TOI to direct measurements of cerebral oxygen supply and consumption in SCD patients. We demonstrate that TOI tracks SvO2 and OEF, suggesting that it is weighted toward venous vascular beds. The relationship of TOI and HbS% has been previously described and could either shifting of the oxygen dissociation curve or mechanical disruption of microvascular integrity. TOI's strong dependence on total hemoglobin (after correction for HbS%) is particularly startling given its independence with oxygen delivery, suggesting that total hemoglobin is acting as a surrogate marker of microvascular disease severity in SCD patients. TableParameterR2pAge (Years)0.0127nsHemoglobin (gm/dl)0.295<0.05Hemoglobin S %0.229<0.05WBC (103/uL)0.0020nsCBF ml/100g/min0.018nsSaO2 (%)0.034nsO2 delivery0.071nsSvO2 (%)0.290<0.05OEF (%)0.238<0.05CMR020.112ns Disclosures Coates: novartis: Honoraria, Speakers Bureau; shire: Consultancy, Honoraria; apo pharma: Consultancy, Honoraria, Speakers Bureau; acceleron: Consultancy, Honoraria.
Dissertations / Theses on the topic "Shiro (Dog)"
1
Arnold, Amanda Suzanne. "Shift." Digital Archive @ GSU, 2007. http://digitalarchive.gsu.edu/english_theses/26.
Full textAbstract:
The following is a collection of original poetry. The manuscript consists of an introduction explaining influences and style, and four chapters of poems categorized by subject matter: object/nature, writing/creativity, relationships, and family/figures. INDEX WORDS: Poetry, Poem
2
Freitas, Joana Ferreira. "Avaliação do ciclo de vida de uma t-shirt de algodão: algodão convencional vs algodão biológico." Dissertação, 2020. https://hdl.handle.net/10216/130286.
Full text
3
Freitas, Joana Ferreira. "Avaliação do ciclo de vida de uma t-shirt de algodão: algodão convencional vs algodão biológico." Master's thesis, 2020. https://hdl.handle.net/10216/130286.
Full textBooks on the topic "Shiro (Dog)"
2
(Illustrator), Karen Sasaki, ed. Shiro in Love: A True Story. Heian International, 1989.
Find full text
3
Adventure, Kosta. Notebook: T-Shirt Dog Funny Cover. Independently Published, 2020.
Find full text
4
lilla. Cornell Notes Notepad: Dog Notebook Journal, 110 Pages, Letter , 101 Days of School Shirt Dabbing Dalmation Dog Soft Cover. Independently Published, 2020.
Find full text
5
Murray, Thameisa. Notebook: Notebook with Dogs, Classic Lined Pages, 110 White Pager, B5 , 101 Days of School Shirt Dabbing Dalmation Dog Soft Cover. Independently Published, 2020.
Find full text
6
lilla. Notebook: Notebook with Dogs, College Ruled Paper, 110 Pages, 8. 5 X 11 , 101 Days of School Shirt Dabbing Dalmation Dog Soft Cover. Independently Published, 2020.
Find full text
7
Shea, Philip. Notebook: Dog Notebook for Girls, Lined Pages, 110 Pages, 7 X 10 , 101 Days of School Shirt Dabbing Dalmation Dog Soft Cover. Independently Published, 2020.
Find full text
8
Long, Stephen. Dot Grid Notebook Paper: Composition Notebook Dog, Dot Grid, 110 Pages, Softcover , 101 Days of School Shirt Dabbing Dalmation Dog Soft Cover. Independently Published, 2020.
Find full text
9
Altman, Travis. Cornell Notes Notepad: Dog Diary Notebook, 110+ Pages, 8. 5 X 11 , 101 Days of School Shirt Dabbing Dalmation Dog Soft Cover. Independently Published, 2020.
Find full text
10
Altman, Travis. Cornell Notes Notepad: Dog Diary Notebook, 110 Pages, 8. 5 X 11 , 101 Days of School Shirt Dabbing Dalmation Dog Soft Cover. Independently Published, 2020.
Find full textBook chapters on the topic "Shiro (Dog)"
1
Howard, Tanya M., Theodore R. Alter, Paloma Z. Frumento, and Lyndal J. Thompson. "Case Study: Mount Mee Wild Dog Program—Moreton Bay Shire, Queensland." In Community Pest Management in Practice, 167–78. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-2742-1_18.
Full text
2
Bhattacharya, Sreedeep. "Till It Lasts the Wash." In Consumerist Encounters, 113–26. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190125561.003.0005.
Full textAbstract:
This chapter explores T-shirt as a commodity, along with images and texts imprinted on it. It discusses the casual, flexible, and androgynous properties of T-shirt, devoid of symbolic depth. It argues that the T-shirt can host a range of texts and images because it is a vacant surface, waiting to be populated with random images and messages. It is so empty and trifling by itself that it requires textual and graphic support in order to communicate. Textual and visual contents of T-shirts are also observed and interpreted to argue that they do not necessarily translate into an obedient subscription of these messages. The mix of wit, sarcasm, and clichés is so ‘casual’ that it does not demand adherence to, involvement with, or even awareness of surface-level meaning. Simultaneously, it also asserts that the popularity of the T-shirt announces an advent and acceptance of the ephemeral, indicating a detached and dispensable relationship with commodities.
3
Ingram, Brannon D. "The Normative Order." In Revival from Below, 55–91. University of California Press, 2018. http://dx.doi.org/10.1525/california/9780520297999.003.0003.
Full textAbstract:
Building on the first chapter, the second develops the context for the Deobandis’ mission of reforming Muslim public life. It begins with a brief overview of two formative concepts—illicit innovation in religion (bid`a) and ascribing divine attributes to entities other than God (shirk)—that animate Deobandi thought. It argues that Deobandis appropriated the fecund legacy of the anti-bid`a and anti-shirk campaigner Muhammad Isma`il even as they distanced themselves from his hermeneutical populism, namely the notion that the Qur’an and the Sunna are easy to understand and, therefore, do not require the mediation of the `ulama. Focusing on the teachings of Hajji Imdad Allah al-Makki and his disciples Rashid Ahmad Gangohi and Ashraf `Ali Thanvi, the chapter then shows how Deobandis applied the discourse of bid`a and shirk to two forms of devotional piety that were central to Indian Sufism: honoring the prophet Muhammad’s birthday (mawlud) and celebrating the Sufi saints’ death anniversaries (`urs).
4
Jerome, Jerome K. "Chapter XI." In Three Men in a Boat and Three Men on the Bummel. Oxford University Press, 2008. http://dx.doi.org/10.1093/owc/9780199537976.003.0012.
Full textAbstract:
How George, once upon a time, got up early in the morning—George, Harris, and Montmorency do not like the look of the cold water—Heroism and determination on the part of J.—George and his shirt: story with a moral—...
5
Bennett, Peggy D. "Bounce." In Teaching with Vitality. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190673987.003.0097.
Full textAbstract:
Have you noticed that every day, every hour, there is opportunity to bounce? It might be a funny expression from your dog, a clever image on a T- shirt, a surprising comment by a student, an endearing story from a colleague, or the sweet expression of a parent’s love. Each of these moments, and so many more, are provided for us all the time. They surround us. When we know to look for them, when we are open enough to notice them, we can feel the bounce that energizes us, at least momentarily. Our worries and tensions can absorb us in our days at school. That takes no effort. But allowing ourselves to be saturated with that heaviness is also allowing ourselves to be captives of our troubling thoughts and harried schedules. We can take a moment to shrug it off. Loosen the crust of tension and protection. Open ourselves to spotting and feeling moments that bounce. Teachers can adopt the habit of looking for and feeling the bounce in our lives. And when we do, we give ourselves a dose of vigor. We revive. When we give access to the appealing and delightful possibilities that rehumanize us, we change ourselves. We smile. We love. We connect to beauty. We become resilient. We feel the bounce.
6
Reader, Ian, and John Shultz. "Concluding comments and new challenges." In Pilgrims Until We Die, 225–36. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780197573587.003.0008.
Full textAbstract:
This chapter emphasises that the Shikoku pilgrimage is not a singular transient event but a recurrent thread in the lives of pilgrims, many of whom plan to continue doing it until they die or are physically unable. They often also do other pilgrimages and have a primary identity as pilgrims. Pilgrimage is unending while the image of life itself as pilgrimage permeates popular understandings of the Shikoku pilgrimage. We introduce a Shikoku pilgrimage T-shirt that symbolically reflects this view of pilgrimage as infinite and unending, arguing that such themes are not unique to Shikoku, although they have rarely been discussed in studies of pilgrimage. Researchers need to look more closely at the issues discussed in this book, for Shikoku pilgrimage shows that pilgrimage is not a transient activity but a life course that pilgrims view as unending.
7
Moore, Samantha. "‘Does this look right?’ Working Inside the Collaborative Frame." In Drawn from Life, 206–20. Edinburgh University Press, 2018. http://dx.doi.org/10.3366/edinburgh/9780748694112.003.0013.
Full textAbstract:
This chapter is written from, and critically examines, the creative and ethical perspectives of animated documentary practitioners. The author, Samantha Moore, focuses particularly on collaboratively ethnographic approaches to, and examples of, animated documentary filmmaking. This chapter asks to what extent the frame within an animated documentary can become a collaborative, co-authored space that creates truly dialogic images. It also enquiries as to how practitioners do or could go about creating, negotiating and sustaining such forms of collaboration. The chapter discusses key examples from the filmmaking practices of the author and her peers, including Shira Avni, who works with the Down syndrome and autistic communities. It does so in order to outline what impacts different forms of collaborative filmmaking approach might have for audience, filmmakers, and documentary subject-participants, especially in the contexts of documentary films that aim to give a voice to marginalised and unrepresented human perspectives.
8
Broughton, Chad. "Chiles, Coyotes, and Vanilla." In Boom, Bust, Exodus. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780199765614.003.0013.
Full textAbstract:
On the Road to Volador were tree-lined, rocky hills, as well as a fútbol field where a few kids kicked around a ball. A boy on a wobbly-wheeled bicycle navigated the dirt path next to the road, spinning his legs as fast as he could to keep up with our truck. Just outside of town, a group of ten women and girls were picking chile piquín on a steep slope above the road. As Josh and I spoke in English to prepare our questions, the women chattered in rapid-fire Spanish to one another, clearly welcoming the work interruption. They had stopped plucking the tiny red and orange chiles, which they collected in two-liter Coke bottles with the tops cut off. Before we could introduce ourselves, an older woman said in Spanish, “It sounds nice, like what we’ve heard on soap operas.” They said they had seen gringos from time to time in Papantla, the municipal seat, and at the pyramids of nearby El Tajin, the spectacular pre-Colombian archeological site. But they claimed during our trip in 2007 that we were the first gringos to visit tiny Volador. The rugged but fertile land around Volador was planted with corn, beans, papaya, chiles, bananas, oranges, mangoes, and other crops. It was more difficult land to farm than that of Agua Dulce. Volador was also more isolated, and it had fewer people. The main difference, though, was that Don Beto Cruz, an absentee landlord from Papantla, owned nearly all of the land surrounding the village. There was no ejido here. Locals traded their labor with Cruz for little plots of land to farm. Wage work in the fields earned about $8 a day, but it was irregular, maybe one or two days a week. Several of the fieldworkers were high school–aged girls earning summer money. Despite the blazing heat, they dressed in jeans or sweatpants and had layers on top to protect against the scratchy fieldwork and the sun. One of the girls wore a white-and-blue shirt that read, “Telesecundaria Mariano Matamoros.” The shirt featured a television with a smiley face inside.
9
Zukin, Sharon. "Union Square and the Paradox of Public Space." In Naked City. Oxford University Press, 2010. http://dx.doi.org/10.1093/oso/9780195382853.003.0011.
Full textAbstract:
At 6 o’clock on a weekday evening in early July, Union Square is most alive. The small, oval park at its center, three acres of green nestled between four broad streets, throbs with music and conversation, with voices rising and swelling to join the steady drone of traffic on all sides. You see children swinging under their parents’ eye in small playgrounds on the park’s northern edge; at the southern end you pick your way carefully through a swarm of a couple hundred young men and women who are milling around the wide, shallow stone steps leading up to the park’s main entrance. Tourists browse the T-shirt and art vendors’ tables while other shoppers stop at the Greenmarket on their way home, and every fifth person in the crowd is making a call or reading a text message on their cell phone. The crowd skews young, mostly under thirty-five, their faces are mainly white but also black and brown and several shades of tan, and you hear a girl ask, “Where are you? Are you in front?” in Japanese on her phone. Next to the subway entrance a lone political demonstrator uses a portable loudspeaker to make a speech against the U.S. president; nearby, under a statue of George Washington on horseback, two New York City police officers, also on horseback, interrupt their early evening patrol to chat with a park cleaner in a bright red uniform and a private security guard in navy pants and a matching cap. So many people are sitting on green wooden benches under the trees that you can hardly find two seats together. Most of the occupants are watching the parade of passersby; some are listening through earbuds to portable music players, others read a book, and one or two doze. In the fenced-in dog run, pets frisk about while their owners laugh and talk. A trio of young musicians sits on benches in the middle of the park, setting up a cello and two violins for an informal outdoor rehearsal.
10
Thomson, Peter. "The Great Circle." In Sacred Sea. Oxford University Press, 2007. http://dx.doi.org/10.1093/oso/9780195170511.003.0019.
Full textAbstract:
The Port of San Francisco, once one of the world’s most celebrated ports of call, has been reduced to this: a quarter-mile of bare, worn asphalt between a chain link fence and the bay, a couple dozen oblong cargo containers stacked like a set of playroom blocks, and one huge gray cargo crane that looms over the water like the skeleton of some Stanford student’s monstrous robotic dog. A few miles to the north, the Embarcadero and its ripsaw ridge of angled piers, once the pulsing heart of the city’s commercial port, is today a palm-tree-lined recreational waterfront of restaurants, bars, condos, and t-shirt vendors, while here to the south of downtown, huge swaths of abandoned waterfront lie fallow, awaiting the next wave of redevelopment. The San Francisco Bay itself remains a major Pacific port, but virtually all of its cargo traffic now moves through the modern container terminals of Oakland, across the bay. In the city of San Francisco itself, there remains only a single active cargo pier, and this is it. Pier 80. Lashed to the far side of the sea of asphalt is a ship, of modest size by contemporary standards but its sheer bulk impressive nonetheless—a hulking mass of emerald green steel looming three stories above the tarmac, a pale yellow superstructure rising eight stories above that in the stern, and a wall of red and blue containers stacked six high above the forward decks. The ship looks awkward and ungainly. It looks like it may well challenge the principles of buoyancy and displacement. It looks like nothing that neither James nor I have ever trusted his life to before. Our hallucinatory float down the Copper River is ten days behind us. We’ve reentered civilization in Anchorage, visited friends in Seattle, finally met Gary Cook of Baikal Watch and our Russia-specialist travel agent Debbie, and made other last-minute arrangements here in San Francisco, and now we’re riding across the acres of asphalt in the back of a battered yellow van and our friend Eleanor, who drove us down here, is repeating, as if a mantra, Oh my god, I can’t believe you’re getting on this thing. . . . Oh my god, I can’t believe . . .
Conference papers on the topic "Shiro (Dog)"
1
Jiang, Xiaoli, and C. Guedes Soares. "Ultimate Capacity Behavior of Pitted Mild Steel Plates Under Biaxial Compression." In ASME 2011 30th International Conference on Ocean, Offshore and Arctic Engineering. ASMEDC, 2011. http://dx.doi.org/10.1115/omae2011-49980.
Full textAbstract:
The aim of the present paper is to investigate the effects of corrosion pits on the ultimate capacity of rectangular mild steel plates under biaxial compression. A series of non-linear FEM analysis on plates with partial depth pits are carried out, changing geometrical attributes of both pits and plates, i.e., the radius, depth, location and distribution of the pits and the slenderness of the plates. Possible interaction between transverse and longitudinal axial compression is studied applying different level of loading ratio and considering the effects of partial depth pitting corrosion. It is shown that biaxial loading ratio is a dominant factor affecting the behavior of pitted plates besides pits intensity and thickness loss at pits. When longitudinal compression is dominant load with loading ratio lower than 1, the interaction relationship curves for different DOP levels tend to be parallel with each other and the distance between every two parallel curves seems to be dependent mainly on the deviation of their DOP values and thickness loss at pits. Moreover, pits distribution along long and shirt edges could also affect the ultimate strength behavior of plates. The work done in the paper illustrates that the ultimate capacity of pitted plate could be derived from intact plate by introducing important influential parameters like DOP, thickness loss and possible pits distribution.
2
Weber, Michael, Abigail Clarke-Sather, Tara Bergeron, Anisa Janko, Alicia Jensen, Brittany Malvick, and Steven Cope. "Development of a Pressure Measuring Garment to Understand How to Quantify Compression." In 2020 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/dmd2020-9024.
Full textAbstract:
Abstract Encouraging research shows reductions in the number of disruptive behaviors for children diagnosed with Autism Spectrum Disorder (ASD) when wearing compression shirts. However, current studies do not consider the amount of pressure compression shirts apply to the body and how different amounts of pressure applied to the body may lead to different outcomes for children diagnosed with ASD. The purpose of this proof of concept research project was to develop a method for measuring the pressure applied by a compression shirt at a specific location on the body. This study used conductive thread as the principle element to measure the compression applied by a garment onto the body, specifically the arm. It was found that for the specific stitch and thread tested, the relationship between the displacement the sensor exhibits and the change in resistance was 25.95 Ω/m. With this relation, the pressure applied by a compression garment to a mannequin arm and the arms of four participants was found. A general trend that the measured pressure applied by a garment onto the body directly correlated with increasing individual arm circumference was found.