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Academic literature on the topic 'ShK'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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Journal articles on the topic "ShK"

1

Crow, James Mitchell. "Venomous drugs: ShK." New Scientist 214, no. 2863 (May 2012): 37. http://dx.doi.org/10.1016/s0262-4079(12)61175-0.

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Pennington, M. "ShK-186 from discovery to clinical development." Toxicon 75 (December 2013): 211. http://dx.doi.org/10.1016/j.toxicon.2013.08.020.

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Diez-Martín, Fernando, Cristina Fraile, David Uribelarrea, Policarpo Sánchez-Yustos, Manuel Domínguez-Rodrigo, Javier Duque, Isabel Díaz, et al. "SHK Extension: a new archaeological window in the SHK fluvial landscape of Middle Bed II (Olduvai Gorge, Tanzania)." Boreas 46, no. 4 (April 13, 2017): 831–59. http://dx.doi.org/10.1111/bor.12246.

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Velazhahan, Rethinasamy, Shima Nasser Hamed Al-Mamari, Abdullah Mohammed Al-Sadi, Issa Hashil Al-Mahmooli, and S. P. Sathish Babu. "In vitro antagonistic potential, plant growth-promoting activity and indole-3-acetic acid producing trait of bacterial isolates from spent mushroom substrate of Agaricus bisporus." Journal of Agricultural and Marine Sciences [JAMS] 25, no. 2 (September 20, 2020): 22. http://dx.doi.org/10.24200/jams.vol25iss2pp22-29.

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Spent mushroom substrate (SMS) is widely used as fertilizer and to control plant diseases. The microorganisms surviving in SMS play a crucial role in plant growth promotion and biocontrol properties of SMS. In this study, an effort was made to isolate and characterize the bacterial species present in the SMS of Agaricus bisporus and to study their antagonistic potential, plant growth-promoting ability and indole-3-acetic acid (IAA) producing trait. Six different bacterial isolates exhibiting morphological variabilities were obtained from the SMS by serial dilution technique. On the basis of 16S rRNA gene sequences, these isolates were identified as Staphylococcus epidermidis (Sh1 and Sh3), S. aureus (Sh2), Bacillus albus (Sh4), Delftia lacustris (Sh6) and Comamonas aquatica (Sh7). These bacterial strains were assayed for their antagonism against Pythium aphanidermatum, a phytopathogenic oomycete. The results of in vitro dual culture assay revealed that all the 6 bacterial isolates showed low levels of suppression of P. aphanidermatum and recorded less than 5 mm inhibition zone. Among the bacterial isolates, S. epidermidis Sh3 recorded the maximum inhibition zone of 4.2 mm. Plant growth promotion test using roll paper towel method revealed that C. aquatica Sh7, B. albus Sh4, D. lacustris Sh6 and S. epidermidis Sh3 caused a significant increase in seedling vigour of cucumber compared to control. The seeds treated with the bacterial isolate C. aquatica Sh7 showed the maximum seedling vigor. Assessment of in vitro production of IAA by the bacterial isolates revealed that the bacterial isolates highly varied (ranging from 0.28 to 9.25 mg L-1) in their potential for production of IAA. The maximum amount of IAA was produced by C. aquatica Sh7 (9.25 mg L-1), while the minimum was produced by S. epidermidis Sh1 (0.28 mg L-1).

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Li, Huachao, Yueming Chen, Jiahao Zhang, Xiangcui Chen, Zheng Li, Bing Liu, and Luyong Zhang. "Shikonin Attenuates Acetaminophen-Induced Hepatotoxicity by Upregulation of Nrf2 through Akt/GSK3β Signaling." Molecules 24, no. 1 (December 29, 2018): 110. http://dx.doi.org/10.3390/molecules24010110.

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Acetaminophen (APAP) overdose-induced acute liver damage is mostly due to overwhelmingly increased oxidative stress. Nuclear factor-erythroid 2-related factor2 (Nrf2) plays an important role in alleviating APAP hepatic toxicity. Shikonin (SHK) enhances Nrf2 in multiple lines of normal cells. Nevertheless, whether SHK protects against APAP-induced liver toxicity remains undefined. This study found SHK defended APAP-induced liver toxicity, as well as reversed the levels of serum alanine/aspartate aminotransferases (ALT/AST), liver myeloperoxidase (MPO) activity, and reactive oxygen species (ROS), while it enhanced the liver glutathione (GSH) level in APAP-treated mice. SHK rescued the cell viability and GSH depletion, but neutralized oxidative stress in APAP-treated human normal liver L-02 cells. Mechanically, SHK increased Nrf2 expression in the exposure of APAP at the protein level but not at the mRNA level. Inhibition of Nrf2 blocked the SHK effect in APAP-treated hepatocytes. Furthermore, SHK improved Nrf2 stability through stimulating PI3K/Akt pathway, thus inhibiting GSK-3β. In vivo studies confirmed the close correlation of liver protection of SHK against APAP and Akt/GSK-3β/Nrf2 pathway. In conclusion, this study reveals that SHK prevents APAP hepatotoxicity by upregulation of Nrf2 via PI3K/Akt/GSK-3β pathway. Therefore, SHK may be a promising candidate against APAP-induced liver injury.

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Ma, Shu-Xin, Li-Bo Tang, Zhi-Hang Chen, Min-Li Wei, Zi-Juan Tang, Yue-Hui Zheng, Guo Zong, and Jia Li. "Effects of shikonin on the development of ovarian follicles and female germline stem cells." Journal of International Medical Research 49, no. 7 (July 2021): 030006052110294. http://dx.doi.org/10.1177/03000605211029461.

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Objective To investigate the effects and potential mechanism of action of shikonin (SHK) on the development of ovarian follicles and female germline stem cells (FGSCs). Methods Female Kunming adult mice were administered SHK (0, 20 and 50 mg/kg) by oral gavage. Cultures of FGSCs were treated with SHK 32 μmol/l for 24 h. The ovarian index in mouse ovaries was calculated. Numbers of primordial, primary and atretic follicles were counted. Germline stem cell markers and apoptosis were examined. Levels of glutathione (GSH), superoxide dismutase (SOD) and reactive oxygen species (ROS) were measured. Results Both doses of SHK significantly decreased the ovarian index, the numbers of primordial follicles, primary follicles and antral follicles in mice. SHK significantly increased the numbers of atretic follicles and atretic corpora lutea. SHK promoted apoptosis in vivo and in vitro. SHK significantly decreased the levels of the germline stem cell markers. SHK significantly lowered GSH levels and the activity of SOD in the peripheral blood from mice, whereas SHK significantly elevated cellular ROS content in FGSCs. Conclusions These current results suggested that follicular development and FGSCs were suppressed by SHK through the induction of apoptosis and oxidative stress might be involved in this pathological process.

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Kalman, Katalin, Michael W. Pennington, Mark D. Lanigan, Angela Nguyen, Heiko Rauer, Vladimir Mahnir, Kathy Paschetto, et al. "ShK-Dap22, a Potent Kv1.3-specific Immunosuppressive Polypeptide." Journal of Biological Chemistry 273, no. 49 (December 4, 1998): 32697–707. http://dx.doi.org/10.1074/jbc.273.49.32697.

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Pasquadibiscesceglie, Andrea, Manuela Cervelli, Jonathan Reinoso Sanchez, Paolo Mariottini, Marco Oliverio, Marco Gerdol, and Maria Vittoria Modica. "ShK-like toxins from the vampire snail Colubraria reticulata." Toxicon 149 (July 2018): 100–101. http://dx.doi.org/10.1016/j.toxicon.2018.02.018.

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Wada, Naoko, Yawara Kawano, Shiho Fujiwara, Yoshitaka Kikukawa, Yutaka Okuno, Hiroaki Mitsuya, and Hiroyuki Hata. "A Small Molecule, Shikonin, Dually Functions As a Proteasome Inhibitor and a Necroptosis Inducer In Multiple Myeloma Cells." Blood 122, no. 21 (November 15, 2013): 3172. http://dx.doi.org/10.1182/blood.v122.21.3172.3172.

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Abstract Background Despite of recent advances in therapeutic strategy for multiple myeloma (MM), MM still remains incurable and novel therapeutic approach is urgently needed. We have previously demonstrated that a natural small molecule, shikonin (SHK), induced both apoptosis and necroptosis (programmed necrosis) in MM cells. In this study, we attempted to elucidate biological mechanisms of SHK in inducing apoptosis and necroptosis. Methods Six MM cell lines, KMS-12-PE, RPMI 8226, U266, KMM1, KMS-11 and a bortezomib-resistant MM cell line, KMS-11/BTZ (obtained from Kyowa Hakko Kirin Co. Ltd.), were utilized. Inhibitors of pan-caspase and necroptosis, ZVAD-fmk and Nec-1 (necrostatin-1), were employed to distinguish apoptosis and necroptosis, respectively. Cell death was analyzed using the trypan blue dye exclusion method (WST-8 assay) and flow cytometry analysis using AnnexinV/PI staining. Morphological examinations of cells were performed with May Giemza staining. Caspases, RIP1, ubiquitinated proteins, and heat shock proteins were analyzed with western blot. Knockdown of RIP1, an essential molecule for necroptosis, was performed using siRNA. ER stress was assessed by detecting activated XBP-1, which was analyzed by digestion of PCR products with ApaLI. Because the ApaLI site in XBP-1 mRNA is spliced out upon activation, the activated XBP-1 shows one large band after ApaLI digestion, while inactivated XBP-1 shows two ApaI-digested bands. Thapsigargin, sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor, was used as an ER stress inducer. Results By screening natural compounds libraries (provided by Institute of Natural Medicine, Toyama University, Japan), we found that SHK, a natural compound derived from the root of Lithospermum erythrorhizon, induced cell death in MM cells. Apoptosis was induced at a relatively low concentration (2.5∼5 µM) and was inhibited by a caspase-inhibitor, while necroptosis was promptly induced at higher concentrations (10∼ 20 µM) within 5 hours and was completely inhibited by Nec-1. Morphological analysis showed that SHK at low concentrations induced typical apoptotic changes, such as fragmented nucleus, while SHK at higher concentrations induced necrotic morphology, such as translucent cytoplasm and swelling of cell membranes. By contrast, SHK did not induce apoptosis or necrptosis in peripheral blood mononuclear cells from healthy donors at low concentrations. SHK activated caspase-8 and -3 at low concentrations but did not at higher concentrations. RIP1, an essential molecule for necroptosis, was cleaved after treatment with SHK at low concentrations, which leads to the inhibition of necroptosis, while it was not cleaved and remained active at higher concentrations, suggesting that SHK dynamically regulates the cleavage of RIP-1. At low concentrations, shikonin induced an accumulation of ubiquitinated proteins and activated XBP-1, suggesting SHK may have a property of proteasome inhibitor eventually inducing endoplasmic reticulum stress. Finally, SHK at low concentration killed bortezomib resistant cells with lower IC50 comparing to that of the parental cells (0.91 vs 1.56 µM, respectively). Conclusions We here report, for the first time, that SHK induces apoptosis and necroptosis in MM cells at low and high concentrations, respectively, by regulating proteasome function and RIP-1 cleavage. Given the fact that SHK efficiently induces cell death in bortezomib-resistant cell line, SHK may act as a novel proteasome inhibitor for bortezomib-resistant myeloma cells. Moreover, SHK at higher concentrations, which induces nectoptosis, should be an attractive future therapeutic option potentially to eradicate MM cells. Disclosures: No relevant conflicts of interest to declare.

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Sachkova, Maria Y., Morani Landau, Joachim M. Surm, Jason Macrander, Shir A. Singer, Adam M. Reitzel, and Yehu Moran. "Toxin-like neuropeptides in the sea anemoneNematostellaunravel recruitment from the nervous system to venom." Proceedings of the National Academy of Sciences 117, no. 44 (October 15, 2020): 27481–92. http://dx.doi.org/10.1073/pnas.2011120117.

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The sea anemoneNematostella vectensis(Anthozoa, Cnidaria) is a powerful model for characterizing the evolution of genes functioning in venom and nervous systems. Although venom has evolved independently numerous times in animals, the evolutionary origin of many toxins remains unknown. In this work, we pinpoint an ancestral gene giving rise to a new toxin and functionally characterize both genes in the same species. Thus, we report a case of protein recruitment from the cnidarian nervous to venom system. The ShK-like1 peptide has a ShKT cysteine motif, is lethal for fish larvae and packaged into nematocysts, the cnidarian venom-producing stinging capsules. Thus, ShK-like1 is a toxic venom component. Its paralog, ShK-like2, is a neuropeptide localized to neurons and is involved in development. Both peptides exhibit similarities in their functional activities: They provoke contraction inNematostellapolyps and are toxic to fish. Because ShK-like2 but not ShK-like1 is conserved throughout sea anemone phylogeny, we conclude that the two paralogs originated due to aNematostella-specific duplication of a ShK-like2 ancestor, a neuropeptide-encoding gene, followed by diversification and partial functional specialization. ShK-like2 is represented by two gene isoforms controlled by alternative promoters conferring regulatory flexibility throughout development. Additionally, we characterized the expression patterns of four other peptides with structural similarities to studied venom components and revealed their unexpected neuronal localization. Thus, we employed genomics, transcriptomics, and functional approaches to reveal one venom component, five neuropeptides with two different cysteine motifs, and an evolutionary pathway from nervous to venom system in Cnidaria.

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Dissertations / Theses on the topic "ShK"

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Bunk, Horst D. [Verfasser]. "Evaluation als eine Methode der kontrollierten Zielerreichung für Qualifizierungsmassnahmen im SHK-Handwerk / Horst D Bunk." Aachen : Shaker, 2004. http://d-nb.info/1172616337/34.

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KAMPANGO, Ayubo Amisse. "Host location by exophagic African Malaria vectors: evaluating the performance of a novel exposure-free human-baited mosquito trap and studies on the perception of indoors/outdoors by malaria vectors in southern Mozambique." Master's thesis, Instituto de Higiene e Medicina Tropical, 2016. http://hdl.handle.net/10362/19829.

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A malária é transmitida por mosquitos que, preferencialmente, picam no interior (endofágicos) ou no exterior (exofágicos) das habitações. Atualmente, os métodos mais sucedidos no controlo vectorial são a pulverização residual intra-domiciliar (PIDOM) e as redes mosquiteiras tratadas com insecticidas de longa duração (REMILD), que têm como alvo principal os vectores endofágicos. No entanto, as espécies que picam no exterior (exófagicas) têm sido as mais difíceis de controlar e, atualmente, não existem métodos satisfatórios para o controlo de populações destes vectores. A transmissão da malária feita por vectores exofágicos é comum fora de África; contudo, o fenómeno vem, progressivamente, ganhando importância também no continente Africano. Daí que, para que os vectores exofágicos sejam controlados de forma efetiva, é necessário entender melhor como ou porquê alguns vectores preferem procurar refeições sanguíneas em ambientes fechados, enquanto os outros evitam entrar em tais compartimentos? Ou seja, como é que um vector localiza e reconhece um ambiente fechado (ou intra-domiciliar) ou aberto (extra-domiciliar)? Com vista a obter respostas à tais questões, varias experiências de campo foram realizadas na aldeia de Massavasse, localizada na região leste do distrito de Chóckwè, província de Gaza, sul de Moçambique. As experiências assentaram-se em dois objetivos principais: 1. Projetar, construir e avaliar a performance de uma armadilha de grelha elétrica, apelidada de armadilha Shock-wè (SHK-wè), que poderá ser utilizada como uma alternativa fiável às colheitas com isca humana, na amostragem de vectores da malária que procuram um hospedeiro humano em ambientes interiores ou exteriores. 2. Determinar a contribuição dos elementos estruturais básicos que compõe uma habitação (ou seja, tecto, paredes, pilares, etc.) para a ocorrência e entrada de mosquitos que procuram uma refeição sanguínea em casas experimentais. Para cumprir o primeiro objectivo, foram feitas colheitas emparelhadas de mosquitos através de armadilhas SHK-wè e colheitas com isca humana (CIH) durante 35 noites consecutivas. Os resultados indicam que a SHK-wè é uma ferramenta segura e fiável para a amostragem e vigilância das populações de vetores importantes da malária em África. SHK-wè mostrou um bom desempenho tanto no interior como no exterior e, portanto, é potencialmente um substituto prático, robusto e seguro para as capturas CIH convencionais. Para cumprir o segundo objetivo, foram igualmente utilizadas armadilhas SHK-wè numa série de experiências de tratamentos randomizados para determinar a resposta das populações de mosquitos locais à presença de componentes estruturais de uma casa experimental construída para o efeito. A experiência foi realizada durante 50 noites consecutivas e constituiu em montagens e desmontagens aleatórias da casa experimental nos seus elementos básicos (isto é, o suporte de metal, paredes inferiores e superiores e o tecto). Os resultados desta experiência sugerem que, contrariamente ao que se conhecia, o tecto da casa é um componente chave para o reconhecimento e entrada dos vectores endofágicos do complexo A. gambiae s.l em ambientes intra-domiciliares. Os dados indicaram que a probabilidade de A. gambiae s.l. entrar numa casa experimental aumenta 4.5 vezes [IRR = 1.50 (0.63 – 2.37; p = 0.001) quando o tecto está presente em comparação com outros tipos de tratamentos
Malaria is, preferentially, transmitted by mosquitoes that bite indoors or outdoors. To date, the most successful vector control methods, namely: indoors residual spraying (IRS) and long lasting insecticide treated bed nets (LLINs) have targeted indoor species. Outdoor biters (exophagic) are difficult to target and no satisfactory control methods exist. Already common outside Africa, outdoor-transmitted malaria is growing in importance within Africa. To target exophagic mosquitoes we need to understand more how/why they choose to enter or to avoid houses, i.e. what do mosquitoes perceive as indoors or outdoors? Field experiments were undertaken in Massavasse, a village located in the eastern region of Chóckwè district, Gaza province, southern Mozambique, to investigate that question and addressing two objectives: 1. To design, build and evaluate an electric net trap (ENT), named the “Shock-wè (SHK-wè) trap” for reliable sampling of mosquitoes responding to human bait, indoors and outdoors; 2. To determine the contribution of simple elements of a house (i.e. roof, walls, partial walls) to occurrence and entry rates of host seeking mosquitoes. To accomplish the first objective, a series of paired field tests were performed to evaluate the performance of SHK-wè trap compared to Human landing catch (HLC) method. Results showed that SHK-wè trap is a safe and reliable sampling and surveillance tool for African malaria vector populations. The trap performed well indoors and outdoors and is potentially a robust and safe practical replacement for the conventional HLC method. To accomplish the second objective, SHK-wè trap was used in a series of randomized treatment-assigning experiments to determine the response of local mosquitoes populations to presence of structural components of a purpose-built experimental house. The experiment consisted on randomly dismantling or reassembling an experimental house into its basic elements (i.e. a frame on a base, lower walls, upper walls and roof). Results from this experiment suggest that, contrarily to current belief, the roof of the house was a key component that triggered endophagic malaria vectors, such as members of A. gambiae complex, to enter. Data indicated that the probability of A. gambiae s.l. entering an experimental house increased 4.5 [IRR = 1.50 (0.63 – 2.37); p = 0.001)] times when the roof was in place compared to other types of treatments.

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Ghorban, Maryam. "Människa – Teknik – Organisation ur ett utredningsperspektiv : En intervjustudie av medarbetare vid Statens haverikommission." Thesis, Högskolan Väst, Avd för psykologi och organisationsstudier, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-6256.

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Human - Technology - Organization (HTO) is a well-established, general unifying concept in the Swedish Accident Investigation Authority (SHK) that represents an approach, knowledge and use of various tools regarding interactions between people, technology and organizational factors. The HTO-perspective is well described in literature but there are few studies on how SHKs staff experiences working according to this method in their investigations. The aim of this study was therefore to describe their HTO-perspective, examine how it is used in the investigations at SHK and describe the investigators experience of working with the HTO-perspective as well as the method's usefulness compared to old methods in accident investigations. A literature study has been conducted in the areas of HTO, Theory of planned behavior (TPB) and safety culture. TPB and safety culture are described in this paper since they highlight the different aspects of a HTO-perspective. The hypothesis was answered by using semi-structured interviews. The interviews were analyzed by a content analysis and themes were identified. Furthermore the material from the interviews was subsequently structured through a Strength – Weakness – Opportunities – Threats analysis (SWOT), i.e. the informants' view on the HTO-perspective was structured based on the strengths, weaknesses, opportunities and threats SHKs staff experience that the method has in the investigative work. The informants consisted of two investigators at SHK who 3have worked with accident investigations for a long time in various roles. The results yielded that the investigators had a positive attitude towards conducting investigations according to the HTO-perspective because they feel that this perspective provides them with cross-competence. A flaw is though that the perspective lacks a structured approach. As a result of this, the investigators own experiences and expertise play a major role in the quality of the investigation. As the study's aim is met and the informants are considered to be experts the validity requirements are also fulfilled.

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Chen, Zhi'e. "Bei Song wen hua shi shu lun." Beijing : Zhongguo she hui ke xue chu ban she, 1992. http://catalog.hathitrust.org/api/volumes/oclc/27065725.html.

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Lindqvist, Mia. "Assessment of the permeability of physiological membranes : A. A study of Stichodactyla helianthus toxin’s potential to penetrate the buccal mucosa and - B. An investigation of the permeability alterations in the blood brain barrier associated with Alzheimer’s disease." Thesis, Uppsala University, Department of Pharmaceutical Biosciences, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-167399.

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A. A study of Stichodactyla helianthus toxin’s potential to penetrate the buccal mucosa Introduction: Buccal mucosa is an alternative route for drug administration and has advantages over other conventional routes by avoiding both enzymes in the gastro intestinal system and the hepatic first passage mechanism. Stichodactyla helianthus toxin (ShK) is a peptide toxin that blocks potassium channels in T lymphocytes and could be a future treatment for autoimmune diseases when finding a suitable way of administration. Aim: The purpose of this part of the study was to develop a robust and reproducible assay for identification and quantification of ShK. The method was then employed for a proof of principle study; determining the concentration of ShK following an in vitro permeability experiment, to evaluate the potential of ShK penetrating the buccal mucosa in porcine tissue. Materials and Methods: An HPLC method was developed and validated. A piece of porcine buccal mucosa was used as a membrane because of its similarities with human buccal mucosa, and cinched in between a modified Ussing Chamber consisting of a donor and a receptor chamber. Samples were withdrawn from the receptor chamber to determine the amount of ShK that had penetrated the membrane. Results: The HPLC method developed for quantification of ShK demonstrated high accuracy and precision. No concentrations of ShK were able to be quantified from the receptor chambers. Conclusions: A robust assay for quantification of ShK was developed but the results from the experiment indicated that ShK could not penetrate the buccal mucosa membrane. B. An investigation of the permeability alterations in the blood-brain barrier associated with Alzheimer’s disease Introduction: The blood brain barrier (BBB) protects the brain from potential dangerous substances by different barrier properties such as tight junctions and efflux transporters such as P-glycoprotein. Previous studies have showed that the barrier functions may be altered in Alzheimer’s disease and thereby increase the exposure to substances that are normally excluded from the brain parenchyma. This could be an issue regarding safety and toxicity of medications used among Alzheimer patients. Aim: The aim of this part of the study was to investigate the difference in brain uptake of verapamil, digoxin, loperamide, propanolol, diazepam and sucrose between 3xTg-AD mice and wild type control mice. Materials and Methods: Female 3xTg-AD mice and control mice of the age 11.5-13.5 months were used. In Situ brain perfusion with radiolabeled substances (n=5-12) was performed and the brain uptake ratio of the substances was compared and statistically analyzed. Results: No difference in the vascular volume was found when comparing 3xTg-AD with control mice. The ratio of diazepam was observed to be higher in the cortex and propranolol higher in the hippocampus, of 3xTg-AD mice. The uptake ratio of verapamil was higher in both the hippocampus and cortex of 3xTg-AD mice whereas digoxin appeared to be lower in the cortex of 3xTg-AD mice. There was no difference in uptake ratio of loperamide between 3xTg-AD and control mice. Conclusions: This study in addition to previously executed studies in our laboratory, showed that the membrane thickness is age dependent in 3xTg-AD and that further studies needs to be conducted on the expression of P-glycoprotein in the BBB in 3xTg-AD and control mice.

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Yu, Kim Lung. "Nan fang shi ge she qun yu wan Qing "shi ge ge ming" /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?HUMA%202007%20YU.

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Sweeney, Michael Cameron. "Synthetic combinatorial peptide libraries and their application in decoding biological interactions." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1118952919.

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Thesis (Ph. D.)--Ohio State University, 2005.
Title from first page of PDF file. Document formatted into pages; contains xv, 151 p.; also includes graphics. Includes bibliographical references (p. 134-151). Available online via OhioLINK's ETD Center

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Yi, Bin. "Lun Mudan shi ge yi shu jing shen yu Zhongguo xin shi de li shi jian gou." Shanghai : Hua dong shi fan da xue, 2007. http://anulib.anu.edu.au/anuonly/ebooks/chinese_thesis_026.pdf.

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Ming, Yau-yau. "A study of Zhang Dai's Shigui Shu Zhang Dai "Shi gui shu" yan jiu /." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B34615933.

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Park, Hyunguk. "Noncovalent Crosslinking of SH1 and SH2 to Detect Dynamic Flexibility of the SH1 Helix." Thesis, University of North Texas, 2000. https://digital.library.unt.edu/ark:/67531/metadc5844/.

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In this experiment, fluorescent N- (1-pyrenyl) iodoacetamide modified the two reactive thiols, SH1 (Cys 707) and SH2 (Cys 697) on myosin to detect SH1-SH2 a -helix melting. The excimer forming property of pyrene is well suited to monitor the dynamics of the SH1 and SH2 helix melting, since the excimer should only form during the melted state. Decreased anisotropy of the excimer relative to the monomeric pyrene fluorescence is consistent with the disordering of the melted SH1-SH2 region in the atomic model. Furthermore, nucleotide analogs induced changes in the anisotropy of the excimer, suggesting that the nucleotide site modulates the flexibility of SH1-SH2 region.

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Books on the topic "ShK"

1

Zhongguo yuan shi she hui shi shu. [Zhengzhou shi]: Zhongzhou gu ji chu ban she, 1986.

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Ai she ying gong she, ed. Yi ben she ying shu. Beijing: Dian zi gong ye chu ban she, 2012.

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Pai she ji shu bai ke. Ha mi bin: Hei long jiang ke xue ji shu chu ban she, 1988.

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zuo, Jiang zeng. Jia ting she ying. Zheng zhou: He nan ke xue ji zhu chu ban she, 2001.

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sen, Wu de. She ying. Shen yang: Liao ning jiao yu chu ban she, 2000.

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), Zhao wei (1986, ed. Shu zi dian shi she xiang ji shu. 2nd ed. Shang hai: Fu dan ta xue chu ban she, 2012.

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bi, Bu zi, and Chen ti ren. Shu dian de deng guang. Shang hai: Shang hai san lian shu dian, 2008.

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hou, Lin fu. Zhan shi yi shu she ji. Bei jing: Bei jing li gong ta xue chu ban she, 2006.

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Nan she shi hua kao shu. Taibei Shi: Li ren shu ju, 2013.

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Ying shi she ying yi shu. Beijing Shi: Beijing guang bo xue yuan chu ban she, 2003.

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Book chapters on the topic "ShK"

1

Otto, Uwe. "Wärmelieferung — Dienstleistung des SHK-Handwerks." In Dienstleistungen — Innovation für Wachstum und Beschäftigung, 173–86. Wiesbaden: Gabler Verlag, 1999. http://dx.doi.org/10.1007/978-3-322-86913-5_18.

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Metelmann, Carsten. "IT-Unterstützung von Instandhaltungs-, Wartungs- und Reparaturprozessen: die Perspektive der SHK-Betriebe." In Hybride Wertschöpfung, 339–47. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-11855-5_14.

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Reuter, Bernd. "Disruptiv direkt statt dreistufig zementiert – Online-Handel für SHK am Beispiel von Reuter.de." In Digitalisierung des Handels mit ePace, 171–86. Wiesbaden: Springer Fachmedien Wiesbaden, 2013. http://dx.doi.org/10.1007/978-3-658-01300-4_10.

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McCarty, Joseph H. "SH2/SH3 Domains." In Encyclopedia of Cancer, 3397–99. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_5278.

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McCarty, Joseph H. "SH2/SH3 Domains." In Encyclopedia of Cancer, 1–3. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_5278-2.

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McCarty, Joseph H. "SH2/SH3 Domains." In Encyclopedia of Cancer, 4201–3. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-46875-3_5278.

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Mayer, B. J., and R. Gupta. "Functions of SH2 and SH3 Domains." In Protein Modules in Signal Transduction, 1–22. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-80481-6_1.

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Norton, Raymond S., Michael W. Pennington, and Christine Beeton. "CHAPTER 10. Case Study 2: Transforming a Toxin into a Therapeutic: the Sea Anemone Potassium Channel Blocker ShK Toxin for Treatment of Autoimmune Diseases." In Drug Discovery, 255–74. Cambridge: Royal Society of Chemistry, 2015. http://dx.doi.org/10.1039/9781849737876-00255.

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Forman-Kay, Julie D., Steven M. Pascal, Alex U. Singer, Toshio Yamazaki, Ouwen Zhang, Neil A. Farrow, and Lewis E. Kay. "Structural, Dynamic, and Folding Studies of SH2 and SH3 Domains." In NMR as a Structural Tool for Macromolecules, 35–47. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-0387-9_3.

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Leung, Alexander K. C., Cham Pion Kao, Andrew L. Wong, Alexander K. C. Leung, Thomas Kolter, Ute Schepers, Konrad Sandhoff, et al. "SHF." In Encyclopedia of Molecular Mechanisms of Disease, 1924. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_8681.

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Conference papers on the topic "ShK"

1

Sugimoto, Masakatsu, and Kimiyo Takahashi. "SHK." In Conference companion. New York, New York, USA: ACM Press, 1996. http://dx.doi.org/10.1145/257089.257093.

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Soulogianni, Alkistis. "Bilateral Cultural Relations between Greece and Europe." In Rīgas 1. starptautiskā hellēnistikas konference. LU Hellēnistikas centrs, 2003. http://dx.doi.org/10.22364/shk.2003.01.

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Lāms, Ojārs, and Ilze Rūmniece. "Ievads." In Rīgas 2. starptautiskā hellēnistikas konference. LU Hellēnistikas centrs, 2008. http://dx.doi.org/10.22364/shk.2008.01.

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Rūmniece, Ilze. "Introduction." In Rīgas 3. starptautiskā hellēnistikas konference. Latvijas Universitāte, 2012. http://dx.doi.org/10.22364/shk.2012.01.

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Estrada, Rosendo, Redwan Huq, Rajeev Tajhya, Satendra Chauhan, Christine Beeton, and Michael W. Pennington. "Kv1.3 Selective Peptides Based Upon N-Terminal Extension and Internal Substitutions of ShK Toxin." In The 24th American Peptide Symposium. Prompt Scientific Publishing, 2015. http://dx.doi.org/10.17952/24aps.2015.238.

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Ongpeng, Jason Maximino C., Kenneth Guevarra, and Sohichi Hirose. "Air-coupled Nonlinear Ultrasonic Test for Reinforced Concrete Beams." In IABSE Conference, Kuala Lumpur 2018: Engineering the Developing World. Zurich, Switzerland: International Association for Bridge and Structural Engineering (IABSE), 2018. http://dx.doi.org/10.2749/kualalumpur.2018.0992.

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Abstract:

<p>Air-coupled ultrasonic test is a non-destructive test method for investigating damage in material. In this paper, reinforced concrete beams with one 8-mm diameter rounded bar were casted and tested under four-point bending test with water-cement ratio of 40% and 60%. The transducers were placed and focused on the horizontal surface with induced 3mm notch at the midpoint where maximum tension occurred and crack formation was located. Frequency domain waveform was used specifically to analyze second harmonic generation (SHG). There were two metrics used under the SHG, these were: second harmonic amplitude (SHA) and second harmonic ratio (SHR). The SHR proved to be consistent for both water-cement ratio and it behaved increasing as damage in tension increases.</p>

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Janik, Ian, and Mohammed A. S. Khalid. "Synthesis and evaluation of SHA-1 algorithm using altera SDK for OpenCL." In 2016 IEEE 59th International Midwest Symposium on Circuits and Systems (MWSCAS). IEEE, 2016. http://dx.doi.org/10.1109/mwscas.2016.7870147.

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Chakroun, Rawia, Ramzi Ben Ayed, and Nabil Derbel. "Comparative analysis of SHE and SHM strategies on grid-connected inverters case." In 2020 17th International Multi-Conference on Systems, Signals & Devices (SSD). IEEE, 2020. http://dx.doi.org/10.1109/ssd49366.2020.9364263.

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Portillo, Ramon, Mohammad Sharifzadeh, Hani Vahedi, Leopoldo G. Franquelo, and Kamal Al-Haddad. "Improved hybrid SHM-SHE modulation technique for four-leg three-level NPC inverters." In IECON 2015 - 41st Annual Conference of the IEEE Industrial Electronics Society. IEEE, 2015. http://dx.doi.org/10.1109/iecon.2015.7392952.

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Tzouvelekis, Argyris, Guoying Yu, Jose Herazo-Maya, Tony Woolard, Yi Zhang, Hojin Lee, Patty Lee, Erica Herzog, Anton Bennett, and Naftali Kaminski. "SH2 domain-containing phosphatase-SHP-2 is a novel anti-fibrotic regulator in pulmonary fibrosis." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.oa4979.

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Reports on the topic "ShK"

1

Foucar, James G. Converting Projects from STK Classic to STK. Office of Scientific and Technical Information (OSTI), August 2014. http://dx.doi.org/10.2172/1171561.

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Nystrom, M. Identifiers and Test Vectors for HMAC-SHA-224, HMAC-SHA-256, HMAC-SHA-384, and HMAC-SHA-512. RFC Editor, December 2005. http://dx.doi.org/10.17487/rfc4231.

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Kelly, S., and S. Frankel. Using HMAC-SHA-256, HMAC-SHA-384, and HMAC-SHA-512 with IPsec. RFC Editor, May 2007. http://dx.doi.org/10.17487/rfc4868.

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Hersi, Amina, Susan Schulman, and Rebecca Wynn. She Leads. Oxfam, September 2020. http://dx.doi.org/10.21201/2020.6393.

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Eastlake, D., and T. Hansen. US Secure Hash Algorithms (SHA and HMAC-SHA). RFC Editor, July 2006. http://dx.doi.org/10.17487/rfc4634.

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Heer, T. STK Bladestore Tests. Office of Scientific and Technical Information (OSTI), November 2003. http://dx.doi.org/10.2172/15013634.

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Eastlake, D., and T. Hansen. US Secure Hash Algorithms (SHA and SHA-based HMAC and HKDF). RFC Editor, May 2011. http://dx.doi.org/10.17487/rfc6234.

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Polk, T., L. Chen, S. Turner, and P. Hoffman. Security Considerations for the SHA-0 and SHA-1 Message-Digest Algorithms. RFC Editor, March 2011. http://dx.doi.org/10.17487/rfc6194.

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Murphy, Pam. IEA SHC Annual Report 2014. IEA Solar Heating and Cooling Programme, May 2015. http://dx.doi.org/10.18777/ieashc-ar-2014-0001.

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Murphy, Pamela, ed. IEA SHC Solar Update Newsletter. IEA SHC, December 2016. http://dx.doi.org/10.18777/ieashc-su-2016-0002.

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