Academic literature on the topic 'Shope fibroma virus'

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Journal articles on the topic "Shope fibroma virus"

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Chang, W., C. Upton, S. L. Hu, A. F. Purchio, and G. McFadden. "The genome of Shope fibroma virus, a tumorigenic poxvirus, contains a growth factor gene with sequence similarity to those encoding epidermal growth factor and transforming growth factor alpha." Molecular and Cellular Biology 7, no. 1 (January 1987): 535–40. http://dx.doi.org/10.1128/mcb.7.1.535.

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Degenerate oligonucleotide probes corresponding to a highly conserved region common to epidermal growth factor, transforming growth factor alpha, and vaccinia growth factor were used to identify a novel growth factor gene in the Shope fibroma virus genome. Sequence analysis indicates that the Shope fibroma growth factor is a distinct new member of this family of growth factors.
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Chang, W., C. Upton, S. L. Hu, A. F. Purchio, and G. McFadden. "The genome of Shope fibroma virus, a tumorigenic poxvirus, contains a growth factor gene with sequence similarity to those encoding epidermal growth factor and transforming growth factor alpha." Molecular and Cellular Biology 7, no. 1 (January 1987): 535–40. http://dx.doi.org/10.1128/mcb.7.1.535-540.1987.

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Abstract:
Degenerate oligonucleotide probes corresponding to a highly conserved region common to epidermal growth factor, transforming growth factor alpha, and vaccinia growth factor were used to identify a novel growth factor gene in the Shope fibroma virus genome. Sequence analysis indicates that the Shope fibroma growth factor is a distinct new member of this family of growth factors.
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3

Willer, David O., Grant McFadden, and David H. Evans. "The Complete Genome Sequence of Shope (Rabbit) Fibroma Virus." Virology 264, no. 2 (November 1999): 319–43. http://dx.doi.org/10.1006/viro.1999.0002.

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Parks, Robin J., Brian D. Lichty, Christina Karakis, and David H. Evans. "Characterization of the Shope Fibroma Virus DNA Ligase Gene." Virology 202, no. 2 (August 1994): 642–50. http://dx.doi.org/10.1006/viro.1994.1385.

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Berkowitz, Elchonon M., and Beatriz G.-T. Pogo. "Molecular characterization of two strains of shope fibroma virus." Virology 142, no. 2 (April 1985): 437–40. http://dx.doi.org/10.1016/0042-6822(85)90354-x.

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Obom, Kristina M., and Beatrix G. T. Pogo. "Characterization of the transformation properties of Shope fibroma virus." Virus Research 9, no. 1 (January 1988): 33–48. http://dx.doi.org/10.1016/0168-1702(88)90048-2.

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Keller, Rachel L., Diane V. H. Hendrix, and Cheryl Greenacre. "Shope fibroma virus keratitis and spontaneous cataracts in a domestic rabbit." Veterinary Ophthalmology 10, no. 3 (May 2007): 190–95. http://dx.doi.org/10.1111/j.1463-5224.2007.00531.x.

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Macaulay, C., and G. McFadden. "Tumorigenic poxviruses: Characterization of an early promoter from shope fibroma virus." Virology 172, no. 1 (September 1989): 237–46. http://dx.doi.org/10.1016/0042-6822(89)90125-6.

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Upton, C., J. L. Macen, R. A. Maranchuk, A. M. Delange, and G. McFadden. "Tumorigenic poxviruses: Fine analysis of the recombination junctions in malignant rabbit fibroma virus, a recombinant between shope fibroma virus and myxoma virus." Virology 166, no. 1 (September 1988): 229–39. http://dx.doi.org/10.1016/0042-6822(88)90164-x.

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Teoh, Melissa L. T., Patricia V. Turner, and David H. Evans. "Tumorigenic Poxviruses Up-Regulate Intracellular Superoxide To Inhibit Apoptosis and Promote Cell Proliferation." Journal of Virology 79, no. 9 (May 1, 2005): 5799–811. http://dx.doi.org/10.1128/jvi.79.9.5799-5811.2005.

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ABSTRACT Tumorigenic leporipoxviruses encode catalytically inactive homologs of cellular Cu-Zn superoxide dismutase (SOD1). The function of the orthologous myxoma virus M131R and Shope fibroma virus S131R gene products is uncertain, but they inhibit SOD1 activity by a process linked to binding its copper chaperone. Using a superoxide-sensitive dye (hydroethidine), we observed that virus infection increased intracellular superoxide levels in an M/S131R-dependent manner. To see whether this effect promotes infection, we deleted the Shope fibroma virus S131R gene and compared the clinical manifestations of wild-type and mutant virus infections in rabbits. S131RΔ virus produced significantly smaller fibroxanthosarcoma-like growths in vivo and, at a point where these growths were already receding, wild-type infections still showed extensive leukocyte infiltration, necrosis, and fibromatous cell proliferation. Coincidentally, whereas Jurkat cells are protected from mitochondria- and Fas-mediated apoptosis by wild-type myxoma virus in vitro, M131RΔ virus could not block Fas-initiated apoptosis as judged by DNA laddering, terminal deoxynucleotidyltransferase-mediated dUTP-fluorescein nick end labeling, and caspase 3 cleavage assays. These data suggest that tumorigenic poxviruses can modulate intracellular redox status to their advantage to stimulate infected cell growth and inhibit programmed cell death.
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Dissertations / Theses on the topic "Shope fibroma virus"

1

Sabourdy, Frédérique. "Poxivirus et tumeurs : influence des facteurs de croissance viraux sur la formation des fibromes de Shope." Toulouse 3, 2004. http://www.theses.fr/2004TOU30277.

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La famille des Poxviridae compte trois virus tumorigènes. Les mécanismes empruntés par ces virus pour induire des tumeurs sont inconnus et semblent originaux. Certains poxvirus codent des homologues de l'EGF qui représentent de bons candidats pour participer à la tumorigénèse. Après une présentation générale de la biologie des Poxviridae, l'auteur s'interesse plus particulièrement au virus du fibrome de Shope (VFS), responsable de fibromes cutanés chez le lapin, dont il présente la symptomatologie et la pathogénie. Elle rappelle les caractéristiques des facteurs de croissance EGF-like cellulaires et viraux et leurs liens avec la tumorigénèse. L'auteur montre que le facteur de croissance du VFS, SFGF, active la prolifération des fibroblastes dans les tumeurs, et pourrait participer aux modifications morphologiques dont ils sont les cibles. Le facteur de croissance du virus myxomateux, MGF, ne peut le remplacer
Only three poxviruses are tumorigenic. The mechanisms they use to induce tumours remain unknown. Some of them encode EGF-like homologs, which represent good candidates for triggering tumorigenesis. The author first gives a general overview of the poxvirus biology. Then, she presents poxvirus tumorigenesis characteristics, using Shope fibroma virus (SFV) as an example. She describes cellular and viral EGF-like growth factors, showing how these peptides could be linked with tumour formation. According to her experimental results, SFV growth factor, SFGF, activates fibroblasts proliferation in fibromas, and could also be involved in their morphological abnormalities. Myxoma virus growth factor, MGF, cannot substitute for SFGF
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