Journal articles on the topic 'Si yang guan li'

Tsau, Yang, Li Guan, and Jian-Young Wu. Initiation of spontaneous epileptiform activity in the neocortical slice. J. Neurophysiol. 80: 978–982, 1998. Cortical local circuitry is important in epileptogenesis. Voltage-sensitive dyes and fast imaging were used to visualize the initiation of spontaneous paroxysmal events in adult rat neocortical slices. Although spontaneous paroxysmal events could start from anywhere in the preparation, optical imaging revealed that all spontaneous events started at a few confined initiation foci and propagated to the whole preparation. Multielectrode recording over hundreds of spontaneous events revealed that often two or three initiation foci coexisted in each preparation ( n = 10). These foci took turns being dominant; the dominant focus initiated the majority of the spontaneous paroxysmal events during that period. The dominant focus and dynamic rearrangement of foci suggest that the initiation of spontaneous epileptiform events involves a local multineuronal process, perhaps with potentiated synapses.

Tujuan penelitian ini adalah untuk menentukan tipologi sektor perikanan di Kabupaten Bandung Barat; menganalisis laju pertumbuhan sektor perikanan dalam lima tahun terakhir (2009-2013) Kabupaten Bandung Barat; dan untuk menganalisis peran perikanan sektor pada pembangunan daerah Kabupaten Bandung Barat. Metode penelitian yang digunakan adalah metode survey dengan menggunakan beberapa teknik analisis, yaitu analisis Klassen Tipologi, analisis (LQ), analisis Localization Index (LI), analisis Spesialization Index (SI) dan Shift Share (SS). Hasil penelitian menunjukkan bahwa potensi terbaik dari komoditas di Kabupaten Bandung Barat adalah ikan patin / Pengasius hypophthalmus (jumlah rata-rata LQ komoditas 1,92). Poin keunggulan daerah dengan menggunakan LQ (rata-rata nilai 1,82), LI (di bawah 0,5), dan SI (0,01 nilai 0,07-0,09 / nilai di bawah 0,5). Titik LQ menunjukkan bahwa sektor perikanan di Kabupaten Bandung Barat adalah sektor basis, tetapi poin lain (LI dan SI) menunjukkan bahwa sektor perikanan bukanlah sektor penggerak pada struktur perekonomian wilayah. Berdasarkan tipologi Klassen dan teknik Shift-Share, sektor perikanan di Kabupaten Bandung Barat merupakan sektor dengan pertumbuhan yang lambat dan kurang kompetitif (pada tipologi klassen berada di kuadran 2).

Indeks stabilitas udara merupakan salah satu parameter yang dapat dihasilkan dari pengolahan data radiosonde. Pemetaan kondisi indeks stabilitas udara di Indonesia belum dilakukan. Diduga terdapat hubungan antara indeks stabilitas udara dengan curah hujan. Data yang digunakan dalam kajian ini adalah data Radiosonde 22 stasiun pengamatan dan data TRMM wilayah Indonesia Tahun 2019. Kajian ini bertujuan menganalisis indeks stabilitas udara di Indonesia secara spasial dan melihat hubungan antara antara indeks stabilitas udara dengan curah hujan. Berdasrkan kajian yang telah dilakukan, bulan Januari merupakan bulan dengan nilai KI, SI, LI, dan TT paling kuat diikuti dengan sebaran curah hujan bulanan yang tinggi. Sedangkan bulan September merupakan bulan paling stabil dengan nilai KI, SI, LI, dan TT paling lemah diikuti dengan kondisi kering di Indonesia. Pergerakan pelemahan indeks stabilitas udara dimulai dari wilayah NTT, NTB, Bali hingga terus melebar ke arah utara dimulai pada bulan Juni, dan perlahan menguat pada bulan Oktober.

Jembat an yang t erl et ak pada ruas j alan Si mpang Lago-Si mpang Buat an Siak Mengkapan But on ti dak memi li ki di mensi i deal karenaukurannya lebi h keci l dari badan j alan. Kondi si i ni menyebabkan lalu li nt as macet t erut ama saat kenderaan besar yang bermuat an tanah at ausawit dat ang dari arah yang berlawanan. Untuk menganti sipasi masalah ini maka Pemeri nt ah t elah melakukan pembangunan j embat an barumenggunakan prat egang I-gi rder. Surat edaran ment eri pekerj aan umum menj elaskan bahwa j embatan dengan bent angan 16 met er lebi h ekonomi smenggunakan bet on bert ulang dari pada menggunakan t i pe st ruktur lai n sehingga di lakukan peneli t i an i ni dengan tujuan mendapat kan st rukt uryang ekonomi s. Pada perenca naan ini dilakuka n per encanaan st rukt ur at as dengan T- gi rd er b et on bert ul ang yang a nalisa beban mengac u padastandard pembebanan SNI T-02-2005 dan SNI T-12-2004 untuk perenca naa n struktur beton bertula ng. Hasi lnya, j embat an memi li ki ukuran lebar laluli nt as 7,6 m dan panj ang 16 m. Tebal slab yang di gunakan 200 mm, di mensi gi rder 500/ 1100 dan di afragma 300/500. Penulangan negat i ve danposi t i f slab masi ng-masing D25-110 dan D22-100. Tulangan t arik girder 18D32 dan t ulangan t ekan 16D19 dengan sengkang D13-100. Bi ayaberdasarkan dat a proyek untuk st rukt ur at as sebesar Rp. 1. 622. 061.000,00, sedangkan berdasarkan perhit ungan menggunakan st ruktur TGirdersebesar Rp. 1.182.228.000,00. Struktur at as j embatan dengan bent ang 16 met er lebi h ekonomi s menggunakan T-gi rder di bandingkanprat egang I-gi rder dengan ti dak mempert i mbangkan pengaruh met ode pelaksanaan, kemudahan quali t y cont rol dan kondi si geografi s proyek.

Pada tahun 2025, diperkirakan kebutuhan baterai Li-ion akan mencapai 400.000 ton. Upaya strategis diperlukan untuk mewujudkan pemakaian baterai Li-ion yang berkelanjutan. Setelah siklus pemakaian baterai Li-ion berakhir, baterai Li-ion akan diproses kembali untuk diambil kandungan logam-logam penting yang terkandung di dalam katoda, terutama litium. Secara umum, proses recycle tersebut dilakukan dengan metode hidrometalurgi yang terdiri atas rangkaian leaching dan presipitasi. Namun demikian, dalam proses pemurnian tersebut dihasilkan air limbah yang mengandung beragam logam dengan konsentrasi yang berbeda. Untuk baterai LFP, logam-logam tersebut berasal dari katoda yang mengandung Li, Na, Si, dan PO4. Proses pelindian dan pencucian serbuk katoda membutuhkan air dalam jumlah yang relatif besar. Pengolahan air limbah hasil proses daur ulang baterai diharapkan dapat secara signifikan meningkatkan efisiensi penggunaan air. Pada eksperimen ini, metode adsorpsi batch dengan ion-exchange resin kation Amberlite HPR1100 Na dan resin anion Dowex Marathon A digunakan untuk menghilangkan ion logam dari air limbah artifisial. Pengambilan sampel air limbah yang diolah diambil pada menit ke-3, 6, 10, 20, 30 dan hari ke-3. Berdasarkan pada hasil removal percentage, diperoleh bahwa pengolahan air limbah artifisial metode adsorpsi dengan menggunakan ion-exchange resin kation Amberlite HPR1100 Na dapat mengurangi kadar ion litium dan natrium sampai 100% pada menit ke-20 dengan variasi dosis adsorben 10 g/100 mL, sedangkan penggunaan ion-exchange resin anion Dowex Marathon A dapat mengurangi kadar ion fosfat sampai 100% pada menit ke-30 dengan dosis adsorben 10 g/100 mL. Dengan adsorpsi isotherm didapat model Langmuir lebih sesuai dengan data eksperimen dengan nilai parameter Qm dan KL untuk ion litium sebesar 1,16 mg/g dan 2,57 mg/g, ion natrium sebesar 74,62 mg/g dan 0,04 mg/gL/mg, dan ion fosfat sebesar 208,33 mg/g dan 0,06 mg/g. Selain itu, studi kinetika menunjukkan bahwa model pseudo second-order memiliki kesesuaian data yang lebih baik daripada pseudo first-order.

Rechargeable post Li-ion batteries based on aluminum (Al) are gaining attention due to high abundance of Al, the high theoretical volumetric capacity, and high safety associated with the low flammability [1,2]. In comparison to Li-ion batteries (LiBs), where the solid-electrolyte interphase (SEI) has been studied for decades, little is known on SEI formation in dependence of the used electrolyte for Al electrodes. In this study, we present the electrochemical performance of Al foils with two different thicknesses (0.025 mm and 0.075 mm), which were used as negative electrode in Al-ion batteries in AlCl3/1-ethyl-3-methylimidazolium chloride [EMIm]Cl electrolyte. Atomic force microscopy (AFM) was used to determine changes in the morphology of Al foils during the charge - discharge process to obtain information on the SEI and its microstructural morphology [3]. Spatially-resolved information on the electrochemical activity of interphase layers on cycled Al foils can be obtained via scanning electrochemical microscopy (SECM), which so far has only be studied at LiBs [4]. First results reveal the correlation between the morphological changes of SEI layer during cycling and its electrochemical behavior depending on the Al foil surface properties, which will be presented and discussed in this contribution. Key words: Al foil, AFM, microstructure, SEI layer, SECM. References: Meng-Chang Lin, Ming Gong, Bingan Lu, Yingpeng Wu, Di-Yan Wang, Mingyun Guan, Michael Angell, Changxin Chen, Jiang Yang, Bing-Joe Hwang and Hongjie Dai, Nature, 520, 325–328 (2015). Li, and N.J. Bjerrum, J. Power Sources, 110, 1–10 (2002). Feng Wu, Na Zhu, Ying Bai, Yaning Gao, and Chuan Wu, Green Energy & Environment 3, 71-77, (2018). Bastian Krueger, Luis Balboa, Jan Frederik Dohmann, Martin Winter, Peter Bieker and Gunther Wittstock. ChemElectroChem,7, 3590–3596, (2020). This work contributes to the research performed at CELEST (Center for Electrochemical Energy Storage Ulm-Karlsruhe) and was funded by the German Research Foundation (DFG) under Project ID 390874152 (POLiS Cluster of Excellence).

A Single-Power Alternating Current (SPAC) instrument was used to measure the low-impedance acupoints around Ho-Ku (LI-4), Yang-Hsi (LI-5), Yang-Ch'ih (TB-4), Yang-Ku (SI-5), T'ai-Yuan (Lu-9), Ta-Lung (EH-7) and Shen-Men (He-7). A four-electrode instrument was used to measure the subcutaneous impedance at these low-impedance acupoints and adjacent control points on 12 healthy people. The mean subcutaneous impedance at the acupoints was 49.8±8.4 Ω, significantly lower than the impedance of 53.5±9.3 Ω for the control points (P<0.005). Of the seven acupoints, five (71%) had significantly lower impedances than the mean impedance for the adjacent control points. Seven of the 14 control points had significantly higher impedances than the adjacent acupoints, with most control points (93%) having higher impedances than adjacent acupoints. In conclusion, subcutaneous impedance is lower at the low-impedance points as measured with the SPAC two-electrode method. One interpretation of these results is that more interstitial fluid lies beneath the low-impedance acupoints.

Provinsi Jawa Barat merupakan wilayah dengan populasi domba terbesar di Indonesia. Analisis perwilayahan ternak domba di Jawa Barat diperlukan untuk memunculkan keunggulan komparatif wilayah. Tujuan dari penelitian ini adalah menganalisis wilayah basis dan karakteristik penyebaran usaha ternak domba di Provinsi Jawa Barat. Metode yang digunakan adalah analisis location quotient (LQ), localization index (LI), dan specialization index (SI). Data yang digunakan adalah data statistik peternakan yang diterbitkan oleh Direktorat Jenderal Peternakan dan Kesehatan Hewan. Hasil dari penelitan ini menyatakan bahwa wilayah basis usaha ternak domba di Provinsi Jawa Barat yaitu di Kabupaten Purwakarta, Kabupaten Garut, Kabupaten Majalengka, dan Kabupaten Cirebon. Usaha ternak domba di Provinsi Jawa Barat tidak terpusat pada satu wilayah kabupaten, dan tidak ada wilayah kabupaten yang mengkhususkan pada usaha ternak domba. Makalah ini juga menyajikan peta wilayah basis dan penjelasan karakteristik peternak domba di Jawa Barat.

Obesity is a disease defined by excessive fat storage in the body. It is an energy balance problem; the increase in body fat is caused by an imbalance between energy intake and energy expenditure. This study aimed to determinate the changes in the anthropometric measurements of patients after acupuncture treatment used in obesity treatment. The present study was a cross-sectional study conducted in 2019 in xxx University's GETAT Center). Patients aged between 18–65 years with a BMI > 25 were included in the study. The participants were divided into two groups: Group 1 (acupuncture and diet) and Group 2 (diet only). Exclusion criteria: Pregnant women, breastfeeding patients , susceptible demographics (acute coronary insufficiency, immunodeficiency, severe psychotic disorder, liver and kidney failure), and those who could not give consent were not included in the study. Weight, BMI, and metabolic age values were measured with a Tanita device; the same diagnostic device was used for all patients. Both body and ear acupuncture were performed. In patients with all acupuncture, the yuan points of abnormal meridians were used for pulse diagnosis. ST 24, 25, and 36 (ZuSanLi); GV 20, 21, 5, 5, and LR 3 (Taichong); SP 6 and 9, GB 34, UB 62, HT 7, LU 9, and PC 6 (Nei Guan); and SI 3 and EXT-HN 3 (Yin-Tang) points were dewed. For ear acupuncture, hunger, kidney, larynx, stomach, jerome, and shen-men points were taken. A t-test was applied to pre- and post-acupuncture measurement values. After acupuncture, the waist circumference of the participants decreased significantly (p < 0.005). The BMI of the participants also decreased significantly after acupuncture (p < 0.005). In these studies, LU 6, ST 40, ST 21, K 4, ST 36 and 25, and LI 11 body points were used, while hunger, stomach, and shen-men points were commonly used as ear points.

The most important cathodic process in alkali metal-air (M-O2) batteries is the electrocatalytic oxygen reduction reaction (ORR) typically forming superoxide (MO2), and peroxide (M2O2).1 Cation size in aqueous solvents have been demonstrated to affect the ORR activity due to the cation hydration energy.2 However, within aprotic electrolytes, the reaction mechanisms and the activity of ORR with respect to cation size remains undetermined. Traditionally, electrochemistry has been involved in the analysis of the reaction mechanisms of ORR. Nonetheless, this technique by itself is not suitable to identify intermediaries and products of the redox reactions taking place at the electrochemical interface. The combination of cyclic voltammetry with in situ Raman spectroscopy provide the opportunity to study and develop a fundamental understanding of the ORR under potential control, accessing reaction pathways and relating them directly to surface structure.3 In this sense, the breakthrough of Shell-Isolated Nanoparticles for Enhanced Raman Spectroscopy (SHINERS)4,5 is noteworthy. SHINERS is a non-destructive, powerful technique for surface analysis that has been demonstrated to provide SERS effect even in the absence of intrinsic roughness and without requiring Au, Ag or Cu to be used as working electrodes.3,5 In this work, electrochemical measurements and SHINERS are utilised to study the effect of cation upon electrified interfaces during ORR. Zhang, J., Zhang, X.-G., Dong, J.-C., Radjenovic, P. M., Young, D. J., Yao, J.-L., Yuan, Y.-X., Tian, Z.-Q. & Li, J.-F. Real-Time Monitoring of Surface Effects on the Oxygen Reduction Reaction Mechanism for Aprotic Na–O2 Batteries. J. Am. Chem. Soc. 143, 20049–20054 (2021). Kumeda, T., Tajiri, H., Sakata, O., Hoshi, N. & Nakamura, M. Effect of hydrophobic cations on the oxygen reduction reaction on single‒crystal platinum electrodes. Nat. Commun. 9, 1–7 (2018). Guan, S., Attard, G. A. & Wain, A. J. Observation of Substituent Effects in the Electrochemical Adsorption and Hydrogenation of Alkynes on Pt{hkl} Using SHINERS. ACS Catal. 10, 10999–11010 (2020). Li, J. F., Huang, Y. F., Ding, Y., Yang, Z. L., Li, S. B., Zhou, X. S., Fan, F. R., Zhang, W., Zhou, Z. Y., Wu, D. Y., Ren, B., Wang, Z. L. & Tian, Z. Q. Shell-isolated nanoparticle-enhanced Raman spectroscopy. Nature 464, 392–395 (2010). Galloway, T. A., Dong, J.-C., Li, J.-F., Attard, G. & Hardwick, L. J. Oxygen reactions on Pt{hkl} in a non-aqueous Na+ electrolyte: site selective stabilisation of a sodium peroxy species. Chem. Sci. 10, 2956–2964 (2019).

DKI Jakarta dikejutkan dengan hujan deras pada jam 16:00 WIB. Genangan airlangsung terjadi akibat derasnya hujan. Hujan berlangsung sampai sekitar jam 20:00WIB. Dari data AWS di Jatiwaringin, curah hujan tertinggi sebesar 230 mm tercatatpada jam 16:00 WIB. Curah hujan sampai jam 19:00 WIB tercatat sebesar 650.60 mmatau intensitas 216.87 mm/jam untuk periode jam 16:00 s.d. 19:00 WIB. Beberapaindeks stabilitas, yang dihitung dari data rawinsonde jam 07:00 WIB, menunjukanpotensi terjadinya aktivitas konvektif yang bisa menghasilkan hujan deras. Beberapaindeks stabilitas yang menunjukan potensi terjadinya proses konvektif kuat adalah: LI(Lifted Index) = - 06; SI (Showalter Index) = - 0.7; K Index = 36.7; TT (Total Totals) =43.9. Kejadian hujan paling deras di kawasan barat DKI Jakarta sampai Tangerang.Genangan air hampir merata di DKI Jakarta dan Tangerang dengan ketinggian yangbervariasi antara 20 cm – 100 cm.Jakarta was struck by torrential rain at 16:00 pm. Standing water caused by heavy rainoccured immediately. The rain lasted until around 20:00 pm. From the AWS measurement at Jatiwaringin, highest rainfall of 230 mm was recorded at 16:00 pm. Rainfall amount until 19:00 pm was recorded of about 650.60 mm, in other words rainfall intensity was about 216.87 mm/hour for the period of 16:00 – 19:00 pm. Some stability indices, which is calculated from rawinsonde at 07:00 am showed the potential for convective activity which could produce heavy rain. Some stability indices that show strong potential for convective process are: LI (Lifted Index) = - 06; SI (Showalter Index) = - 0.7; K Index = 36.7; TT (Total Totals) = 43.9. The heaviest rainfall occured in the western region of Jakarta until Tangerang. Stagnant water is almost evenly in Jakarta and Tangerang with varying heights between 20 cm - 100 cm.

Abstract Background: In this study, we aimed to observe initial palliative treatment choices and clinical outcomes for premenopausal hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer patients (MBC) in the Chinese population in real life.Methods: The China National Cancer Center database was used to identify 2194 MBC patients diagnosed between 2004 to 2015. Premenopausal patients with HR+ HER2- MBC were included. Clinicopathological features, initial palliative treatment choices and survival information were extracted. First-line progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan–Meier method and compared using the log-rank test. Prognostic factors associated with OS were analyzed using Cox regression model with 95% confidence interval (95%C.I.).Results: A total of 451 premenopausal patients meeting study criteria were identified. Median age was 44 years. The number of patients receiving chemotherapy alone, endocrine therapy and chemotherapy followed by endocrine therapy as initial palliative treatment strategy were 222(49.2%), 80 (17.7%), and 149 (33.0%), respectively. Patients receiving initial chemotherapy were more likely to be luminal B subtype, had more de novo stage IV disease than recurrent disease and had more liver metastasis, compared with patients receiving initial endocrine therapy. Both PFS and OS were significantly longer for chemotherapy-endocrine therapy group (median PFS 18.9 months and OS 75.0 months), than for endocrine therapy group (median PFS 11.7 months and OS 53.5 months). Chemotherapy alone group presented with worst survival outcomes (median PFS 7.1 months and OS 43.9 months). However, in multivariate analysis, none of the three treatment strategies were independently associated with PFS or OS.Conclusions: In real world, a high percentage of premenopausal patients with HR+ HER2- disease received chemotherapy as initial palliative treatment in China, which was not associated with worsened survival. This unexpected guideline non-adherence reflects the unmet need of establishing treatment guidelines specifically for premenopausal patients in the Chinese population. Further studies with larger sample size across China are needed to explore the relationship between this guideline non-adherence and clinical outcomes. Citation Format: Yiqun Li, Hongnan Mo, Xiuwen Guan, Shaoyan Lin, Zijing Wang, Yimeng Chen, Shanshan Chen, Qiao Li, Ruigang Cai, Jiayu Wang, Yang Luo, Ying Fan, Peng Yuan, Pin Zhang, Qing Li, Fei Ma, Binghe Xu. In real world, a high percentage of premenopausal patients with hormone receptor-positive, HER2-negative metastatic breast cancer receive chemotherapy as first-line treatment: A study of the National Cancer Center, China [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-16-06.

ABSTRACT The World Health Organization (WHO) and the United Nations Children's Fund (UNICEF) recommend that infants only be given breast milk for at least 6 months, and breastfeeding continues until the child is two years old. Based on WHO data, only 44% of newborns in the world were breastfed within the first hour of birth, there were only a small number of infants under the age of 6 month who had exclusive breastfeeding. Indonesia has reached the target of exclusive breastfeeding coverage, but there wre still 2 provinces that did not meet the target, namely West Papua (34%) and Maluku (37.2%). Insufficient breast milk production will eventually have a negative impact on the infant since he or she will be susceptible to disease and infection which further may lead to infant mortality or stunting as well as decreased intelligence in the future stage of life. One of the efforts that can be performed to increase breast milk production is acupressure technique. To determine the effect of acupressure therapy on breast milk production among postpartum women through the Systematic Literature Review method. The current study applied the Sytematic Literature Review method. The databases involved literatures published in Pubmed, Google Scholar, Science Direct in accordance with the inclusion and exclusion criteria. Of 14 journals published, most of them were published in 2019 as many as 6 journals (42.85), 8 journals (57.15%) were published Nationally, 11 journals (78.55%) applied a Quasi-experimental design and most of respondents aged 20-35 years and most of respondents were primiparous women. Before the acupressure therapy, all women experienced insufficient breast milk and after the acupressure therapy there was a significant increase in the breast milk production. Acupressure technique was performed gently at the Shangzhong (CV-17), Shaoze (SI-1), Ying Chuang (ST 16), Ru Gen (ST 18), He Ku (LI 4), Cu San Li (ST 36), dan San Yin Chiao (SP 6) meridians during 5-10 minutes regularly, once a day. Acupressure was very influential on the increase in breast milk production since it can increase the levels of the prolactin and oxytocin hormones. Keywords: Acupressure, Postpartum, Breast milk Production ABSTRAK Word Health Organization (WHO) dan United Nations Children’s Fund (UNICEF) merekomendasikan bayi hanya diberikan Air Susu Ibu (ASI) paling sedikit 6 bulan, dan pemberian ASI dilanjutkan sampai bayi berumur dua tahun. Berdasarkan data WHO, bahwa hanya 44% dari bayi yang baru lahir di dunia yang mendapatkan ASI dalam waktu satu jam pertama sejak lahir, masih sedikit juga bayi di bawah usia 6 bulan menyusui secara eksklusif. Indonesia telah mencapai target cakupan ASI eklusif, akan tetapi masih ada 2 lagi Provinsi yang tidak memenuhi target yaitu Papua Barat (34%) dan Maluku (37,2%). ASI tidak cukup akan berdampak buruk pada bayi ibu yaitu bayi ibu akan mudah terkenah penyakit dan infeksi akibatnya bayi bisa meninggal dan di kemudian hari bayi ibu bisa stunting dan penurunan kecerdasan otak bayi. Salah satu upaya yang dapat digunakan untuk meningkatkan produksi ASI yaitu menggunakan teknik akupresur. Mengetahui pengaruh terapi akupresur terhadap produksi ASI pada ibu nifas dengan metode Sytematic Literature Review. Penelitian ini menggunakan metode Sytematic Literature Review, dengan databased yang digunakan Pubmed, Google Scholar, Science Direct yang sudah sesuai dengan sesuai dengan kriteria inklusi dan eksklusif. dalam 14 jurnal tahun terbit terbanyak di tahun 2019 sebanyak 6 jurnal (42.85), publikasih jurnal dan Bahasa yang digunakan Nasional 8 jurnal (57.15%), dengan desain Quasi eksperimen 11 jurnal (78.55%) dan karakteristik responden semuanya berusia 20-35 tahun dengan primipara terbanyak yang sebelum di lakaukn terapi akupresur semua ibu mengalami ketidakcukupan ASI dan sesudah di lakuakan terapi akupresur ada peningkatan yang signifikan pada produksi ASI ibu, teknik akupresur yang dilakukan dengan lembut pada titik merdian Shangzhong (CV-17), Shaoze (SI-1), Ying Chuang (ST 16), Ru Gen (ST 18), He Ku (LI 4), Cu San Li (ST 36), dan San Yin Chiao (SP 6) selama 5-10 menit secara rutin 1 x sehari. Akupresur sangat berpegaruh terhadap peningkatan produksi ASI karena akupresur dapat meningkatkan kadar hormon prolaktin dan oksitosin. Kata kunci: Akupresur, Postpartum, Produksi ASI

Abstract Background: Biomarkers that could predict the beneficial effects of immune checkpoint inhibitors (ICIs) in combination with chemotherapy in treatment-naive advanced or recurrent gastric or gastroesophageal junction (G/GEJ) adenocarcinoma patients are lacking. Methods: We conducted a retrospective analysis of patients with G/GEJ adenocarcinoma who had undergone first-line treatment with programmed death-1 (PD-1) inhibitor plus chemotherapy between October 2017 and July 2021. Comparative analysis of the objective response rate (ORR) was performed using the Chi-square or Fisher’s exact tests. Survival curves were plotted by the Kaplan-Meier analysis and compared for significance with a log-rank test. Univariate and multivariate Cox proportional hazard models were established for evaluating the prognostic value of clinicopathological factors. Results: Of the 172 enrolled patients, 142 showed measurable lesions. The ORR was 52.8%. Higher response rates were observed in patients with age greater than or equal to 60 (p = 0.013), non-diffuse type (p &lt; 0.001), synchronous metastasis (p = 0.029), distant lymph node metastasis (p = 0.002), non-peritoneal metastasis (p= 0.002), HER2 positivity (p = 0.002), and PD-L1 CPS greater than or equal to 5 (p = 0.017). Through univariate analysis, age, histology, number of metastatic sites, and peritoneal metastasis were found to be associated with progression-free survival (PFS). Through multivariate analysis, peritoneal metastasis occurrence was the only identified independent indicator of poor PFS (HR 2.768, 95% CI 1.184-6.472, p = 0.019). Additionally, multi-factor combination results showed that patients with at least one of the following: mismatch repair-deficient (D-MMR)/microsatellite instability-high (MSI-H), HER2 (+), EBV (+), and/or PD-L1 CPS greater than or equal to 5, exhibited higher response rates and longer PFS as compared to those lacking these factors; this benefit was consistent after excluding PD-L1 expression. Among the clinical combinatorial factors, significantly poor ORRs and lower PFS were observed in patients with age &lt; 60, diffuse type, and peritoneal metastasis as compared to those without any of these factors. Conclusions: Peritoneal metastasis was an independent biomarker of poor efficacy to immunotherapy combined with chemotherapy in G/GEJ cancer patients in first-line setting. Some combination factors could be beneficial for efficacy prediction. Citation Format: Yu-Ting Sun, Shi-Xun Lu, Ming-Yu Lai, Xia Yang, Wen-Long Guan, Li-Qiong Yang, Yu-Hong Li, Feng-Hua Wang, Rui-Hua Xu, Miao-Zhen Qiu. Predictive biomarkers for the efficacy of PD-1 inhibitors plus chemotherapy for gastric/gastroesophageal junction cancer in first-line setting [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5092.

<p class="AbstractEnglish"><strong>Abstract:</strong> On February 12, 2017, there was a phenomenon of heavy rain in the Sungailiat area, Bangka Regency which is located at coordinates 1 ° 52'43.14 " S and 106 ° 6'57.29" E. Rain occurs from early morning at around 20.00 UTC or 3:00 WIB with a peak of heavy rain starting at 22.00 UTC or 05.00 WIB. The phenomenon of heavy rain caused several areas to be submerged by flooding, especially in the Sungailiat Inpres Market area, In front of the Bangka Regent office, and the fishing village. This research was conducted to measure environmental conditions when they occur. Analysis of this data uses Radiosonde air observation data on the Pangkal Pinang Meteorological Station which was processed with RAOB (The Universal RAwinsonde OBservation Program) software, and Himawari-8 Weather satellite image data processed with SATAID software then analyzed descriptively. The results show that the rain phenomenon that occurred on February 12, 2017, by the results of Himawari-8 satellite image analysis is at -75^oC in the 22.00 to 23.00 UTC range and the above air index analysis is KI 27.5, LI - 4, 6, SI-0.3, TT 45.4 and SWEAT 205.4 is used when events are very unstable which affects the growth of convective clouds and produces bad weather.</p><p class="KeywordsEngish"><strong>Abstrak:</strong> Pada tanggal 12 Februari 2017, telah terjadi fenomena hujan lebat di wilayah Sungailiat, Kabupaten Bangka yang terletak pada koordinat 1°52'43.14" LS dan 106°6'57.29" BT. Hujan terjadi sejak dini hari sekitar pukul 20.00 UTC atau pukul 03.00 WIB dengan puncak hujan lebatnya terjadi mulai pukul pukul 22.00 UTC atau pukul 05.00 WIB. Fenomena hujan lebat tersebut menyebabkan beberapa wilayah di sungailiat terendam oleh banjir terutama didaerah Pasar Inpres Sungailiat, depan kantor Bupati Bangka, dan kampung nelayan. Penelitian ini dilakukan untuk meninjau kondisi fisis atmosfer saat kejadian secara analisis faktor cuaca lokal untuk mengetahui penyebab dari fenomena tersebut. Analisis dari kejadian ini menggunakan data pengamatan Radiosonde udara atas Stasiun Meteorologi Pangkal Pinang yang diolah dengan software RAOB (<em>The Universal Rawinsonde Observation Program</em>), dan data citra satelit cuaca Himawari-8 yang diolah dengan software SATAID kemudian dianalisa secara deskriptif. Hasil identifikasi menunjukan bahwa fenomena hujan lebat yang terjadi pada tanggal 12 Februari 2017 dipengaruhi oleh suhu puncak awan dari hasil analisa citra satelit himawari-8 berada di angka -75^oC pada rentang jam 22.00 sampai 23.00 UTC dan analisa indeks udara atas yaitu KI 27.5, LI -4.6, SI -0.3, TT 45.4 dan SWEAT 205.4 mengindikasikan bahwa udara atas pada saat kejadian sangat labil yang memicu pertumbuhan awan-awan konvektif dan berpotensi menghasilkan cuaca buruk.</p>

There is rapidly growing interest in the electrochemical reduction of both nitrite and carbon dioxide to mitigate environmental concerns and produce fuels and commodity chemicals (1). Urea is an important target in this area since it is the most widely used nitrogen fertilizer, and can also be used as a fuel and source of hydrogen. It can be produced simultaneously by electrochemical coreduction of NO2 - and CO2 (2-7). Various TiO2 based catalysts such as Cu-doped TiO2 (7) and FeTiO3 (4) have been reported to be effective for co-reduction of CO2 and NO2 -. Metallophthalocyanine catalysts have also been found to be effective in a gas-diffusion electrode configuration under ambient conditions (3). The primary objective of this research is to develop fast and straightforward methodologies that can be routinely used to comprehensively evaluate and compare commercial and new catalysts for co-electrolysis of CO2 and NO2 - in an anion exchange membrane multi-cathode electrolysis cell under ambient conditions. The second objective is using this methodology to synthesize urea and develop reliable and consistent urea measurement methods using various techniques including spectrophotometric, 1H-NMR, mass spectrometry, and enzyme-based methods. It was found that NO2 - and the electrolyte can cause interference during urea measurement. In this research, commercial catalysts such as iron (II) phthalocyanine were used for co-electrolysis of CO2 and NO2 -. Acknowledgements This project is funded in part by the Government of Canada. / Ce projet est financé en partie par le gouvernement du Canada, and by Memorial University References C. Tang, Y. Zheng, M. Jaroniec and S. Z. Qiao, Angew. Chem. Int. Ed., 60, 19572 (2021). M. Shibata, K. Yoshida and N. Furuya, J. Electrochem. Soc., 145, 2348 (1998). M. Shibata and N. Furuya, Electrochim. Acta, 48, 3953 (2003). P. Siva, P. Prabu, M. Selvam, S. Karthik and V. Rajendran, Ionics, 23, 1871 (2017). Y. G. Feng, H. Yang, Y. Zhang, X. Q. Huang, L. G. Li, T. Cheng and Q. Shao, Nano Lett., 20, 8282 (2020). N. N. Meng, Y. M. Huang, Y. Liu, Y. F. Yu and B. Zhang, Cell Reports Physical Science, 2 (2021). N. Cao, Y. L. Quan, A. X. Guan, C. Yang, Y. L. Ji, L. J. Zhang and G. F. Zheng, J. Colloid Interface Sci., 577, 109 (2020).

This study aims to describe the sound patterns of magical words of Pacu Jalur procession through stylistics study. By using the descriptive method and interview of the respondents living at Koto Kombu, Kuantan Hulu, Kuantan Singingi, the data, in forms of the magical words, are analyzed through several satages; transcripting, translating, classifying and formulating the research findings. The research findings show that the sound patterns of magical words of Pacu Jalur contain /sipata/, /ma/, /ka/, /rang/, /ja/, /al/ dan /si/, and assonanse consisting the sound pattern of /i/, /a-a-o/, and /a-a/. The rhemes include an initial position rheme with the pattern of a-a and sound pattern of /nan/, /un/, /di/, /ba/, /da/, /lah/, /no/, /ja/, /al/, /nan/, /di/, /ba/, /hai/, /nan/, and sound pattern of /un/, a middle position rheme with the pattern of a-a dan sound pattern of /do/, /pah/, /nan/, /uo/, /ngan/, /li/, /do/, /ang/, dan /au/, a final position rheme with the pattern of a-a-a and sound pattern of /mo/, /to/, /yu/, /to/, dan /au/, a twin rheme of thre pattern of aa-bb and sound pattern of /nan/-/uak/ and /kan/-/kat/, the pattern of (aa-bb) with the sound pattern of /lam/-/yu/, the pattern of (aa-aaa) with the sound pattern of /nan/, the pattern of (aaa-bb) with the sound pattern of /uak/-kan/ and /kat/-/hai/, and cross rheme containing the pattern of ab-ab with the sound pattern of /o/ /h/-/o/ /h/.AbstrakPenelitian ini bertujuan untuk mendeskripsikan pola-pola bunyi dalam mantra prosesi pacu jalur melalui kajian stilistika. Dengan menggunakan metode deskriptif dan teknik wawancara dari informan yang tinggal desa Koto Kombu, Kuantan Hulu, Kuantan Singingi data berupa mantra dianalisis dengan langkah-langkah mentranskripsikan, menerjemahkan, mengklasifikasikan, menginterpretasikan data, dan merumuskan hasil penelitian. Hasil yang diperoleh adalah mantra-mantra dalam prosesi pacu jalur terdiri atas MMK, MPK, MMPJ, dan MMJ dengan pola-pola aliterasi yang meliputi bunyi /sipata/, /ma/, /ka/, /rang/, /ja/, /al/ dan /si/, dan asonansi meliputi bunyi /i/, /a-a-o/, dan /a-a/. Rima mencakup pada posisi rima awal dengan pola a-a dan bunyi /nan/, /un/, /di/, /ba/, /da/, /lah/, /no/, /ja/, /al/, /nan/, /di/, /ba/, /hai/, /nan/, dan bunyi /un/, rima tengah dengan pola a-a dan bunyi /do/, /pah/, /nan/, /uo/, /ngan/, /li/, /do/, /ang/, dan /au/, rima akhir memiliki pola a-a-a dan bunyi /mo/, /to/, /yu/, /to/, dan /au/, rima kembar pola (aa-bb) dan bunyi /nan/- /uak/ dan /kan/-/kat/, pola (aa-bb) dengan bunyi /lam/-/yu/, pola (aa- aaa) dengan bunyi /nan/, pola (aaa-bb) dengan bunyi /uak/-kan/ dan /kat/-/hai/, dan rima silang memiliki pola ab-ab dengan bunyi /o/ /h/-/o/ /h/.

<p><strong>Abstract.</strong> Both epoch-making high accuracy map of Japan named 日本分野図, Nihon bunya zu “Allocation Map of Japan” (Dr. Kazutaka Unno called it as “Astronomical Map of Japan”)compiled by Japanese Cartographer 森幸安 Kouan Mori in 1754,and following, 改正日本輿地路程全図”Kaisei Nihon Yochi Rotei Zenzu “Revised General Route Map of Japan” by 長久保赤水 Sekisui Nagakubo in1779 were created according to the latitude data observed in 14 provinces in Japan recorded in 天文瓊統 Tenmon Keitou (book of Astronomy and divination in Japan) written by Japanese astronomer 渋川春海 Harumi Shibukawa. And in 天文瓊統 Tenmon Keitou (book of Astronomy and divination in Japan) the latitude of 北京 Beijing, 南京 Nanjing and 高麗 Korea recorded in 四海験測 Si hăi yān tsē Nationwide survey conducted by 郭守敬 Guo Shoujin et al in1279 in 元 Yuan Dynasty were displayed for revision of calendar to new 授時暦 Shoushi-li calendar. 渋川春海 Harumi Shibukawa adopted 授時暦 Shoushi-li calendar formulated by 郭 守敬 Guo Shoujin et al to his 貞享改暦 Joukyou revision of calendar in Japan 1685. This proves that the technology of observation of the latitude in Japan was transmitted from China for revision of calendar and observed latitude datas recorded in Tenmon Keitou were exploited to the cartography of Map of Japan without land survey project.</p><p>In 1754 森幸安 Kouan Mori compiled his 日本分野図, Nihon bunya zu “Allocation Map of Japan” by Chinese technology of 方格図 fānggētu grid map east and west equidistant from the distance of latitude 1° by Chinese Cartographer 羅洪先 Luo Hong xian’s 廣輿図 Guan YuTu, “Vast map of China” in Ming. Kouan Mori improved his map of Japan to realise the particularity in each allocation grid. Kouan Mori learned global atlas from duplicate the Matteo Ricchhi’s 坤輿万国全圖 Kunyu Wanguo Quatu:general map of Myriad countries on the earth 1602. In 1779, 長久保赤水 Sekisui Nagakubo made many modifications to the Kouan Mori’s maps and improve it to carry in pocket, named 改正日本輿地路程全図 Kaisei Nihon Yochi Rotei Zenzu “Revised General Route Map of Japan” and published it. Since 1809, this Nagakubo’s map has been repeatedly duplicated and translated into the language of each country in Europe and published, in Russia in 1809 and 1810, in France in 1827 by name of famous Surveyor Krusenstern. In 1855&amp;ndash;1862 by United Kingdom Admiralty published the map “Japan Nipon (mean Honshuu Island) Kiusiu and Sikok and a part of coast of Korea” based on a replica map by Krusenstern in 1827. However, these were published without knowing the name of the Japanese original author Sekisui Nagakubo.</p>

Abstract Background: Gastric cancer (GC) ranks the fifth most common cancer and the fourth most frequent cause of cancer-related deaths. Genomically stable gastric cancers (GSGCs) represent 20% of all GCs and GSGC patients have the worst prognosis among all GC subtypes. Although two HER2-targeted antibody-drug conjugates (ADCs), RC48 and DS8201, have shown promising clinical efficacies, most GSGC patients do not benefit from these ADCs due to the infrequent and heterogeneous HER2 expression. Therefore, there remains a significant and unmet medical need for developing novel ADCs targeting GSGC tumors. Methods: In this presented study, a quantitative and unbiased approach was first used to identify potential targets for GSGC in a panel of human GSGC cell lines in reference with two normal human gastric epithelial cells. Cell membrane localizations of potential targets on GSGC cell lines were determined by immunofluorescent (IF) staining. To correlate it with clinically-relevant GSGC tumor samples, immunohistochemical (IHC) staining of potential targets were performed in human diffuse GC tumor tissues along with normal gastric tissues. Next, GSGC cellular internalization capability of antibodies against potential targets was evaluated. Then, an optimized target was selected for developing GSGC-targeted ADCs. A series of ADC formulations with different linkers and payloads were constructed and characterized. Their anti-tumor activities against GSGC cell lines were subsequently screened in order to identify the optimized ADC formulation. Eventually, the anti-tumor activity and biosafety profile of the optimized ADC formulation were determined in suppressing tumor growth, progression and metastasis by using established orthotopic and peritoneal metastasis models of GSGC. Results: We first identified CD54 as a potential molecular target for human GSGCs using comparative flow cytometric analysis. We next evaluated its potential as an ADC target for GSGC-targeted therapy by determining its overexpression levels, cell membrane localizations, and cell internalization activity in GSGC cells. Furthermore, we constructed and characterized a panel of CD54-targeted ADCs and identified an optimized ADC formulation by quantitatively determining their half maximum inhibitory concentrations (IC50s) and validated its anti-tumor efficacy against GSGC tumors. Meanwhile, there was no evidence to indicate histopathological damages to normal organs in the optimized ADC treated group. Conclusions: In this study, we identified a molecular target for GSGC using an unbiased and quantitative screening assay and explored its potential application in developing GSGC-targeted ADCs. In order to maximize its efficacy, we optimized the ADC formulations against GSGC cells using different ADC linkers and payloads. Our study provides a promising targeted therapeutic candidate for the clinical treatment of GSGC. Citation Format: Rui Xu, Li Yuan, Xiao-Qing Guan, Shi-Li Yao, Bing Zhu, Tong Yang, Chun Liu, Peng Guo, Jiang-Jiang Qin, Xiang-Dong Cheng. Rationally developing antibody drug conjugates targeting genomically stable gastric cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5293.

<p class="AbstractEnglish"><strong>Abstract</strong>: Heavy rain is the weather phenomena that could pose a risk to human life such as floods. Heavy rains caused by atmospheric instability. To find stable or unstable in the atmospheric condition can use the air stability index analysis. Analyzing the stability index of air can help predict the chances of heavy rain. In case of occurrence of heavy rain in the area of Bogor on 9,10 and 11 November 2018, viewed of index SI, LI, SWEAT, CAPE on the lowest value. The expected conclusion is that there is a relation between rainfall data and stability index. Himawari-8 satellite image from monitoring at the time of the scene showed a thick cloud cover in the area of Bogor during rain events.</p><p class="KeywordsEngish"><strong>Abstrak:</strong> Hujan lebat merupakan fenomena cuaca yang dapat menimbulkan resiko bagi kehidupan manusia seperti banjir. Hujan lebat disebabkan oleh ketidakstabilan atmosfer. Untuk mengetahui stabil atau labilnya kondisi atmosfer dapat menggunakan cara analisis indeks stabilitas udara. Menganalisis indeks stabiltas udara dapat membantu dalam memprediksi peluang terjadinya hujan lebat. Dalam kasus kejadian hujan di wilayah Bogor pada tanggal 9, 10, dan 11 bulan November 2018 dilihat dari indeks SSI, LI, SWEAT, CAPE pada saat kondisi terendah, pada umumnya kondisi atmosfer menengah stabil. Walaupun dalam beberapa kejadian nilai SSI menunjukan kondisi atmosfer menengah stabil dan CAPE berada pada nilai potensi konvektif lemah. Dari pantauan citra satelit Himawari-8 pada saat kejadian menunjukkan tutupan awan tebal di wilayah Bogor pada waktu kejadian hujan.</p>

Introduction: In each country more than 50% of the average woman still experiences menstrual pain. Meanwhile, in Indonesia, it is estimated that 55% of women of reproductive age suffer from pain during menstruation. The purpose of the study was to review non-pharmacological interventions regarding facial acupressure (BL-2, Yin Tang, GV 23, GB 15, Tai Yang, GB 14, Ex Hn4, TE 23, Sang Ming, LI-20, Ex Hn 8, ST-3, Si 18, Du 26, REN 24, JiaCenjiang, SJ21, SJ17, GB-2) and Mozart classical music in reducing pain in primary dysmenorrhea. Methods: This research is quantitative with a quasi-experimental design. The approach in the research used is pre-post test design. In November-January 2022 at Megarezky University Makassar. The sample in this study were 28 dysmenorrheal adolescents aged <25 years who were divided into two groups, namely a full-blooded face and classical music group. Results: There were pre and post differences in the acupressure and classical music groups with pain intensity (p=0.002). And there was no significant difference between the full-blooded face group and classical music (p=0.20<0.05). Conclusion: There is an effect of giving face acupressure and classical music in reducing pain and anxiety in primary dysmenorrhea.

Silicon carbonitride (SiCN) is a wide bandgap semiconductor material that has drawn significant interest over the past few decades due to its excellent optical, electrical, and mechanical properties[1]. Rare earth doping in wide bandgap semiconductors has several prospective applications in the field of photoelectric devices, solid-state lasers, flat panel displays, and high-energy radiation detectors [2]. Among the various rare earth materials, europium (Eu) is particularly interesting due to its optically active divalent and trivalent states capable of emitting in different visible spectral ranges [3]. In this work, Eu-doped SiCN thin films were prepared by electron cyclotron resonance plasma-enhanced chemical vapor deposition (ECR-PECVD) with integrated magnetron sputtering [4] on p-type 3” Si (100) substrates. Silane (diluted in 90% argon), nitrogen (diluted in 90% argon) and ethane (C2H6) were used as precursor gases, and a 99.9% pure Eu sputtering target was used as a sputtering source. To understand the effect of C incorporation in the Eu-doped SiCN matrix, we have prepared a set of samples without C. The as-deposited samples were annealed over a wide range of temperatures from 600 to 1100° C in an internet N2 environment. Rutherford backscattering spectrometry (RBS) was performed to determine the atomic concentration of the constituents. Variable angle spectroscopic ellipsometry (VASE) analysis was performed to investigate the optical properties of the films. The room temperature photoluminescence (PL) experiments were carried out with a laser diode excitation source, operating at a wavelength of 375nm. Finally, we performed nanoindentation measurements to understand the deformation behavior of SiCN films as a function of the incorporation of C. The indentation hardness and Young’s modulus of the films were investigated for different Eu and C concentrations. References: [1] Q. Li, Y. Wang, X. Shan, X. Wang, and W. Zhao, “Preparation and optical properties of SiCN thin films deposited by reactive magnetron sputtering,” J. Mater. Sci. Mater. Electron., vol. 28, no. 9, pp. 6769–6781, 2017. [2] Z. Ma, J. Zhou, Z. Chen, and E. Xie, “Luminescence properties of terbium-doped SiCN thin films by rf magnetron reactive sputtering,” Diam. Relat. Mater., vol. 20, no. 4, pp. 475–479, 2011. [3] X. Zhang, D. Yang, D. Li, and M. Wang, “Intense photoluminescence from Eu-doped silicon-rich silicon oxide films prepared by electron beam evaporation,” IEEE Int. Conf. Gr. IV Photonics GFP, pp. 66–68, 2009. [4] J. W. Miller, Z. Khatami, J. Wojcik, J. D. B. Bradley, and P. Mascher, “Integrated ECR-PECVD and magnetron sputtering system for rare-earth-doped Si-based materials,” Surf. Coatings Technol., vol. 336, pp. 99–105, 2018.

The ongoing pandemic of COVID-19 has forced us to consider using available drugs in the shortfall of vaccines and established treatment. Cotrimoxazole is one of the oldest drugs presently used in the prevention and treatment of opportunistic infections in the human immune deficiency virus (HIV) etc. It is a combination of two drugs Trimethoprim and Sulfamethoxazole. This cost-effective old drug is well tolerated among the population with the concomitant use of folic acid; moreover, it also looks after the secondary infections. To conclude, Cotrimoxazole can be used as critically ill COVID-19 patients. References Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive care Med. 2020;46(5): 846–48. https://doi.org/10.1007/s00134-020-05991-x Rozin A, Schapira D, Braun-Moscovici Y, Nahir AM. Cotrimoxazole treatment for rheumatoid arthritis. Semin Arthritis Rheum. 2001;31(2):133-41. Bourke CD, Gough EK, Pimundu G, Shonhai A, Berejena C, Terry L, et al. Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation. Sci Transl Med. 2019;11(486): eaav0537. https://doi.org/10.1126/scitranslmed. aav0537 Liu B, Li M, Zhou Z, Guan X, Xiang Y. Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)? J Autoimmun. 2020; 111:102452. https://doi.org/10.1016/j.jaut.2020.102452 Vickers IE, Smikle MF. The immunomodulatory effect of antibiotics on the secretion of tumour necrosis factor alpha by peripheral blood mononuclear cells in response to Stenotrophomonas maltophilia stimulation. West Indian Med J. 2006;55(3):138-41. https://doi.org/10.1590/s0043-31442006000300002 Onyebuagu PC, Kiridi K, Pughikumo DT. Effects of septrin administration on blood cells parameters in humans. Int. J. Basic Appl. Innov. Res, 2014;3(1): 14 -8. https://www.ajol.info/index.php/ijbair/article/view/104688 Ho JMW, Juurlink DN. Considerations when prescribing trimethoprim– sulfamethoxazole. CMAJ. 2011; 183(16):1851-8. https://doi.org/10.1503/cmaj.111152 Mahan CS, Walusimbi M, Johnson DF, Lancioni C, Charlebois E, Baseke J, et al. Tuberculosis treatment in HIV infected Ugandans with CD4 counts .350 cells/mm3 reduces immune activation with no effect on HIV load or CD4 count. PLoS one.2010;5(2): e9138. https://doi.org/10.1371/journal.pone.0009138 Varney VA, Smith B, Quirke G, Parnell H, Ratnatheepan S, Bansal AS, et al. P49 the effects of oral cotrimoxazole upon neutrophil and monocyte activation in patients with pulmonary fibrosis and healthy controls; does this relate to its action in idiopathic pulmonary fibrosis. Thorax. 2017;72: A109. http://dx.doi.org/10.1136/thoraxjnl-2017-210983.191

The ageing rate and consequentially service life of mass-produced lithium-ion batteries depends on many external and internal factors. Some of the more important ones are the charge-discharge rate, ambient temperature, electrode thickness and state of health (SoH). This makes the estimation of the lifetime of battery cells very challenging and time-consuming. This motivates the development of models capable of determining the ageing behavior of a battery cell with relatively little experimental data. In this study1 we build on our previous work2,3 and use Arrhenius plots of the ageing rate to analyze the service life of battery cells in a relatively simple and straightforward way. We cycle aged two types of cells – commercial 5 Ah high-energy 21700 cells with Si/graphite anode (≈3 % Si) and LixNi0.90Co0.05Al0.05O2 + LiyNiO2 (NCA + LNO) cathode and lab-made 0.1 Ah pouch cells with LixNi0.33Mn0.33Co0.33O2 (NMC111) cathode and graphite anode. The ageing is ensured by systematically cycling the cells in a temperature range of -15 °C to 60 °C at various C-rates (0.2 C – 1 C). The capacity fade data is analyzed to obtain the ageing rate (% of SoH per cycle) as a function of temperature, which forms the V-shaped Arrhenius plots shown in Figure 1. Each set of data clearly shows two slopes that cross at intermediate temperatures. As shown previously experimentally2,3 and theoretically,4 the slopes correspond to two ageing mechanisms – lithium plating in the low temperature region and growth of solid-electrolyte interface (SEI) at high temperature region. The intersection of the two Arrhenius slopes denotes a transition between the dominating ageing mechanism and also denotes the optimum temperature at which the battery cell has the highest service life. By analyzing the data, we show that the crossover temperature shifts towards higher temperature values with increasing C-rate and increasing thickness of the anode, as both increase the electrode area-normalized current. The crossover temperature depends on the SoH of the battery. The precise trend depends on the cell chemistry, as we observe increase of the crossover temperature for one type of cells and decrease of crossover temperature for the other type of cells. The shift of the crossover temperature to lower temperatures observed in pouch cells could be explained by a more rapid loss of cyclable lithium, whereas the shift towards higher C-rates observed in commercial 21700 cells can be observed due to increasing practical C-rates as the electrodes degrade and loose some of their initial capacity. By using relatively little input data, we are able to predict the temperature- and C-rate-dependent end of life of a battery cell with good precision. Evaluating the Arrhenius-type dependences of the ageing rate of the battery cells provides valuable insights for use in battery management systems and extending the service life of battery cells. Acknowledgements Gints Kucinskis acknowledges Latvian Council of Science project “Cycle life prediction of lithium-ion battery electrodes and cells, utilizing current-voltage response measurements”, (no. LZP-2020/1-0425). The part of the research performed at ZSW was carried out in the framework of the industrial collective research program (IGF no. 20884 N/2). It was supported by the Federal Ministry for Economic Affairs and Energy (BMWi) through the AiF (German Federation of Industrial Research Associations eV) based on a decision taken by the German Bundestag. References G. Kucinskis, M. Bozorgchenani, M. Feinauer, M. Kasper, M. Wohlfahrt-Mehrens, T. Waldmann, submited to J. Power Sources. T. Waldmann, M. Wilka, M. Kasper, M. Fleischhammer, and M. Wohlfahrt-Mehrens, J. Power Sources, 262, 129–135 (2014) https://linkinghub.elsevier.com/retrieve/pii/S0378775314004352. M. Bozorgchenani, G. Kucinskis, M. Wohlfahrt-Mehrens, and T. Waldmann, J. Electrochem. Soc., 169, 030509 (2022) https://iopscience.iop.org/article/10.1149/1945-7111/ac580d. X.-G. Yang and C.-Y. Wang, J. Power Sources, 402, 489–498 (2018) https://linkinghub.elsevier.com/retrieve/pii/S0378775318310462. Figure 1. Arrhenius plots based on ageing rate for (a-e) commercial 21700 cells at 100 %, 95 %, 90 %, 85 % and 80 % of SoH and (f,g) lab-made pouch cells at 100 % and 95 % SoH. Figure 1

Abstract Gastric cancer (GC) ranks the fifth common cancer worldwide. Patients with GC suffer from a low 5-y survival rate due to the lack of effective treatments. Based on the genomic and molecular characteristics of GC, the Cancer Genome Atlas (TCGA) classified GC into four molecular subtypes: microsatellite-instable (MSI), Epstein-Barr virus-positive (EBV), chromosomal-instable (CIN), and genomically stable (GS). CIN tumors usually occur at gastroesophageal junction and normally belong to intestinal type of Lauren classification, which are characterized by DNA anueploidy, abnormal chromosomal copy numbers, and the frequent mutation of gene TP53, leading to chromosomal instability. CIN represents the most prevalent GC subtype (&gt;50%) with a poor prognosis, highlighting a significant and unmet medical need for developing effective CIN-targeted therapeutics. Antibody drug conjugates (ADCs) are a new class of targeted therapeutics, composed of a humanized monoclonal antibody and small molecular cytotoxic drugs via chemical linkers. In this study, we designed and engineered a novel ADC targeting chromosome instable gastric cancer (CINGC). We first explored intercellular adhesion molecule-1 (ICAM1) as a novel molecular target for CINGC by characterizing its overexpression levels in a panel of human GINGC cell lines. ICAM1 is a cell surface transmembrane glycoprotein with functions of regulating cell-cell adhesion, signaling, and transendothelial migration of leukocytes to sites of inflammation. Many malignant tumors including GC were found to aberrantly overexpress ICAM1 on the surfaces of tumor cells. The high overexpression of ICAM1 on CINGC cells was validated by using flow cytometry (FCM) quantitatively and immunofluorescence (IF) staining qualitatively. To correlate it with clinically relevant GC tumor tissues, immunohistochemical (IHC) staining of ICAM1 was then conducted to determine the high expression of tumor tissue compared with para cancer tissue. The antigen-mediated endocytosis of ICAM1 monoclonal antibody was further detected by FCM quantitatively and IF visually. All the results showed that ICAM1 was an promising molecular target for CINGC, therefore, it was selected to engineer CINGC-targeted ADCs. We engineered a panel of ADC formulations with different linkers and cytotoxic payloads. We identified an optimal ADC formulation for CINGC by screening their cytotoxicity against CINGC cells in vitro in comparison with first line chemodrugs including 5-FU and oxaliplatin, which efficacy was validated by measuring its inhibitory activity on tumor growth, progression and metastasis via CINGC xenograft models. In conclusion, a novel ICAM1 ADC was designed and engineered to selectively recognize and ablate CINGC cells in vitro and in vivo. Our engineered new ADC offers the possibility of improving the clinical outcome and life quality of CINGC patients and expanding the scope of clinical use of drugs. Citation Format: Xinyan Wang, Li Yuan, Xiaoqing Guan, Shili Yao, Bing Zhu, Chun Liu, Tong Yang, Peng Guo, Jiangjiang Qin, Xiangdong Cheng. A novel antibody drug conjugateengineered for chromosome instable gastric cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5072.

Abstract Background: Metronomic chemotherapy, defined as frequent administration of. chemotherapeutic agents at a non-toxic dose without extended rest periods, can overcome drug resistance and achieve disease control with reduced toxicity compared to conventional chemotherapy in maximum tolerated dose by shifting the therapeutic target from tumor cells to tumor endothelial cells. Some of the previous studies of oral vinorelbine have shown good data in efficacy and safety in advanced breast cancer. Methods: The multicenter, open-label, non-inferiority, randomized phase 2 study (NCT03854617) aimed to evaluate the efficacy and safety of oral metronomic vinorelbine in 13 hospitals in China. Eligible HER2-negative breast cancer patients previously treated with anthracycline or taxane regimens were randomized (1:1) to receive metronomic dosage of oral vinorelbine (50mg/3 times a week) or conventional dosage of oral vinorelbine (60mg/m2 weekly for cycle 1 and 80mg/m2 weekly for subsequent cycles in the absence of grade 3 or 4 toxicity) for first-line/second-line chemotherapy. The primary end point was Disease Control Rate (DCR) and a non-inferiority margin of 6% was defined for DCR. Patient characteristics, progression-free survival (PFS), overall survival (OS) and safety/adverse events (AEs) were among the parameters assessed. The expression of 27 cytokines was profiled longitudinally in these patients at baseline and at regular intervals during therapy. Results: Between February 2019 and September 2020, a total of 171 patients were enrolled and randomized to metronomic dosage group (86 patients) and conventional dosage group (85 patients). 136 patients were hormone receptor(HR)positive and 117 patients (68.4%) had visceral metastases. The DCR was 59.3% (95% CI:48.17% to 69.78%) in the metronomic dosage group and 67.1% (95% CI:56.02% to 76.87%) in the conventional dosage group. Whereas, the 18-month survival rate was higher in the metronomic dosage group than that in the conventional dosage group (68.7% vs 43.0%).The median progression-free survival in the metronomic dosage group was 2.8 months (95% CI:1.40 to 3.50) compared with 4.1 months (95% CI:2.80 to 6.20) in the conventional dosage group. Grade 3 or higher adverse events were significantly less frequent in patients in the metronomic dosage group than patients in the conventional dosage group (19.8% vs 48.2%, P&lt;0.001). By comparing the variation of cytokine profiles at baseline and after 6-week treatment in 122 patients, multilevel partial least squares discriminant analysis (PLS-DA) suggested the variation of VEGF, MIP-1α, IL-1B, IL-17, MCP-1, IL-13, PDGF-BB, IL-4 and RANTES were significantly different between the metronomic dosage group and the conventional dosage group during the treatment (all VIP values &gt; 1.2). As for the patients in the metronomic dosage group, GM-CSF, MCP-1, TNF-α, IL-10, IL-13 and MIP-1α were potential biomarkers between the response patients and non-response patients (all VIP values &gt; 1.2). Conclusions: Oral metronomic vinorelbine decreased the risk of severe toxicity significantly and may be an option for older patients and for those intolerable to standard chemotherapy with proper predictive biomarkers, though this study couldn’t prove to show the non-inferiority of oral metronomic vinorelbine for first-line or second-line chemotherapy previously treated with anthracycline or taxane in HER2-negative metastatic breast cancer. Citation Format: Fei Ma, Xinlan Liu, Yanxia Shi, Xiuwen Guan, Huihui Li, Xiaojia Wang, Yuee Teng, Qiang Liu, Jin Yang, Man Li, Qingyuan Zhang, Weihong Zhao, Caiwen Du, Lili Sheng, Binghe Xu. A randomized phase II study investigating oral metronomic vinorelbine versus conventional dosage of vinorelbine in HER2-negative metastatic breast cancer previously treated with anthracycline or taxane:clinical results and biomarker analysis [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-16-02.

Increasing demands for cost-effective electric vehicles and electrochemical energy storage systems require advanced secondary batteries with higher energy density, longer lifetime, and enhanced safety. Increase of the battery operating voltage is one realistic strategy to extend the energy density, but it is accompanied by irreversible structural changes to the electrodes and parasitic reactions within an electrode-electrolyte interphase resulting in capacity fading and subsequent battery failure. Therefore, a fundamental understanding of underlying electrochemical mechanisms in the electrodes during battery cycling is critical for the development of next-generation secondary batteries. Based on our previous studies utilizing in situ surface-enhanced Raman spectroscopy to monitor the evolution of the Si-electrolyte interphase1 and in situ ATR-FTIR to investigate the voltage dependent electrolyte solution structure changes at the interface, transition metal redox chemistry, and cathode/electrolyte interfacial layer evolution,2 recently we updated the in situATR-FTIR with a newly designed ‘full-cell’ that enables us to analyze the interfacial reactions and interactions on the surfaces of both electrodes that directly influence battery performance, lifetime, and safety. Specifically, we focus on transition metal complex formation and its effect on solid-electrolyte interphase (SEI) formation and evolution on the anode due to transition metal dissolution and crosstalk of Mn-rich cathodes at high voltages (≥4.4 V). In addition, using our multi-modal characterization—a combination of in situ gas chromatography with flame ionization detection (GC-FID) and in situ ATR-FTIR—(electro)chemical degradation of the electrolyte is correlated with gas evolution in the battery. For example, GC-FID measures increasing amounts of ethylene gas until the end the first charging cycle of a LiNiO2//Graphite cell with Gen2 electrolyte (LiPF6 in ethylene carbonate (EC):ethyl methyl carbonate (EMC), 3:7 wt.%). Concurrently, in situ ATR-FTIR shows decreasing concentration of EC solvent, as calculated from the FTIR intensity of EC vibrational absorption. Ethylene is a known by-product of ethylene carbonate electrochemical reduction and is produced during SEI formation.3 Quantifying multiphase reactions occurring during battery operation is critical to understanding and mitigating battery degradation pathways, and developing next-generation battery materials systems. References: Ha, B. J. Tremolet de Villers, Z. Li, Y. Xu, P. Stradins, A. Zakutayev, A. Burrell and S.-D. Han, “Probing the Evolution of Surface Chemistry at the Silicon-Electrolyte Interphase via In-situ Surface-Enhanced Raman Spectroscopy,” J. Phys. Chem. Lett. 2020, 11, 286-291. J. Tremolet de Villers, J. Yang, S.-M. Bak and S.-D. Han, “In Situ ATR-FTIR Study of Cathode-Electrolyte Interphase: Electrolyte Solution Structure, Transition Metal Redox, and Surface Layer Evolution,” Batter. Supercaps 2021, 4, 778-784. Han, C. Liao, F. Dogan, S. E. Trask, S. H. Lapidus, J. T. Vaughey and B. Key, “Using Mixed Salt Electrolytes to Stabilize Silicon Anodes for Lithium-Ion Batteries via in Situ Formation of Li–M–Si Ternaries (M = Mg, Zn, Al, Ca),” ACS Appl. Mater. Interfaces 2019, 11, 29780-29790.

Penelitian ini berjudul “Strategi Pengembangan Perkebunan Kelapa Sawit di Provinsi Jambi”. Penelitian ini bertujuan untuk mengetahui dan menganalisis komoditi kelapa sawit di Provinsi Jambi, mengetahui dan menganalisis tingkat spesialisasi dan lokalisasi komoditi kelapa sawit di Provinsi Jambi serta Rekomendasi strategi pengembangan komoditi kelapa sawit di Provinsi Jambi, Pendekatan yang digunakan adalah pendekatan kuantitatif dan kualitatif. Komoditi kelapa sawit berdasarkan luas dan produksi merupakan komoditi unggulan, sedangkan berdasarkan tenaga kerja komoditi kelapa sawit tidak menjadi komoditi unggulan dan berdasarkan hasil perhitungan daya saing komoditi kelapa sawit Provinsi Jambi dibawah rata-rata. Hasil perhitungan LI komoditi kelapa sawit Provinsi Jambi dapat diinterprestasikan dapat diinterprestasikan bahwa tingkat persebaran komoditi kelapa sawit di Provinsi Jambi penyebaran sektor relatif tidak seimbang dan terkonsentrasi di beberapa tempat tertentudan hasil perhitungan SI Provinsi Jambi tahun 2013-2017 terdapat spesialisasi komoditi kelapa sawit dan setiap kabupaten memiliki kontribusi positif terhadap perkebunan di Provinsi Jambi. Hasil analisis SWOT komoditi kelapa sawit, maka diperoleh : Kekuatan : Perkebunan kelapa sawit di Provinsi Jambi merupakan komoditas unggulan dimana Provinsi Jambi merupakan salah satu sentra produksi kelapa sawit, tersedianya lahan yang cukup luas karena karakter lahan pertanian provinsi Jambi cocok untuk tanaman perkebunan khususnya kelapa sawit, Provinsi Jambi merupakan provinsi spesialisasi komoditas kelapa sawit dengan lokasi yang cenderung teraglomerasi dan dukungan Pemerintah Provinsi dan Kabupaten dalam bentuk kebijakan dan program.. Kelemahan : tidak optimalnya penyerapan tenaga kerja komoditas perkebunan kelapa sawit, rendahnya produktifitas dari komoditi perkebuan kelapa sawit, rendahnya daya tarik dan daya dukung investasi. Selain itu juga isu deforestasi dan konflik sosial karena terdapat distorsi tata kelola dan implementasi peraturan dan nilai tambah dan diversifikasi produk yang dihasilkan belum optimal masih didominasi minyak sawit mentah dan produk turunan sederhana (Olein dan stearin) dan ekspor minyak sawit masih banyak pada produk hulu. Peluang : Perubahan pangsa produksi 4 (empat) minyak nabati utama dunia, penerapan kebijakan Pemerintah China program B5 dan kemampuan Pemerintah India hanya bisa memenuhi kebutuhannya sebesar 30 persen minyak nabatinya, penetapan kebijakan mandatori biodiesel di Indonesia hingga mencapai B-30 pada tahun 2025 mendatang dan Kebijakan Pemerintah Republik Indonesia dalam mengembangkan industri hulu dan hilirisasi kelapa sawit nasional. Ancaman : Kebijakan luar negeri dalam membatasi impor CPO dan produk turunannya dari Indonesia, isu adanya anggapan bahwa pemerintah daerah melakukan politisasi perizinan, sehingga izin pembangunan perkebunan kelapa sawit tidak terkendali, kenaikkan bea masuk atas CPO dari sebesar 7,5 persen menjadi 15 persen, serta kenaikan pajak impor RPO (refined palm oil) dari 15 persen menjadi 25 persen dan fluktuasi harga bagi petani dan pelaku usaha karena industri kelapa sawit di Provinsi Jambi masih didominasi minyak sawit mentah dan produk turunan sederhana dan ekspor minyak sawit masih banyak pada produk hulu.

The demand for lithium-ion batteries continues to grow as the need for renewable energy increases. Over the past few decades, lithium-ion batteries have seen widespread adoption in portable electronics, and they are increasingly being used in electric vehicles. To satisfy the energy density needed for these next-generation applications, new anode materials with high-energy densities are required. Traditional graphite is a very stable intercalation-based anode, but its low capacity has driven many researchers to identify alternatives. Silicon (Si) has one of the highest gravimetric energy densities known when alloyed with lithium. Unlike graphite which is limited to 1 lithiumion per 6 carbon atoms (LiC6), the lithium-silicon alloy Li15Si4 has nearly 4 lithium ions per silicon atom. This gives silicon a theoretical capacity of 3579 mAh/g, compared to the 372 mAh/g for graphite. However, the challenge with silicon (and most alloy anodes) is its poor stability— as the alloying of lithium and silicon is accompanied with a 300% volume expansion. On a microscopic scale, this causes material/electrode swelling and pulverization, which in turn causes severe capacity fade in a few cycles. The binder is known to play an important role in the cycle stability of silicon-based anodes for lithium-ion batteries. Polyvinylidene fluoride (PVDF) has traditionally been the binder used in the preparation of both graphite anodes and lithium metal oxide cathodes. It is electrochemically stable; that is, it is not reduced at the low potential of the anode (~5 mV vs Li) and is not oxidized at the high potential of the cathode (5 V vs Li). However, PVDF has three main disadvantages. First, PVDF cannot accommodate the large volumetric expansion of silicon lithiation. As a result, batteries using PVDF as a binder with silicon will experience a very rapid drop in capacity. Second, PVDF is not water soluble and requires the use of organic solvents like N-Methyl-2-pyrrolidone (NMP) during electrode processing. Finally, the cost of PVDF is approximately 20 USD/kg, which is several times greater than competing binders like sodium carboxymethylcellulose (NaCMC) at 6 USD/kg. Next-generation binders should be inexpensive, able to accommodate the expansion of silicon, and use environmentally friendly processing. Natural biopolymers (such as NaCMC and xanthan gum XG) are a promising class of binders that offer several advantages over traditional polyvinylidene fluoride (PVDF). Biopolymers contain many carboxylate and hydroxyl functional groups which aid in the formation of noncovalent bonding with the oxide surface of silicon. In particular, xanthan gum is a high molecular weight polysaccharide produced extracellularly by the bacteria Xanthomonas campestris. It is water soluble and thus eliminates the need for organic solvents. In addition, its high molecular weight is known to provide better capacity retention, owing to the long molecular chains that can accommodate silicon expansion. While existing studies have explored the fundamental properties of these biopolymer binders and their interaction with silicon, there has been little research on the use of these binders under realistic processing conditions (≤ 10 wt% binder). Herein, we optimize the electrochemical performance of both NaCMC and XG-based silicon electrodes with a low binder content. In addition, we report results for both a high-silicon (≥80 wt%) and a practical low-silicon (20 wt%) composite, all while using nano silicon prepared by industrial-scale synthesis. Figure 1 below shows the capacity retention of different electrode preparations. A higher initial capacity is expected with 80% silicon. However, the overall stability is superior for the low silicon-high graphite (G) composites. Keywords: high-capacity anodes; binders; biopolymers; silicon; lithium-ion batteries Figure 1. Capacity vs cycle number for 1st Generation Si-based electrodes. Cycled at C/10. References H. Yim, S. Niketic, N. Salem, O. Naboka, and Y. Abu-Lebdeh, J. Electrochem. Soc., 164, A6294–A6302 (2017). Zhao, S. Niketic, C. H. Yim, J. Zhou, J. Wang, and Y. Abu-Lebdeh, ACS Omega, 3, 11684–11690 (2018). M. Courtel and Y. Abu-Lebdeh, “Use of Xanthan Gum as an Anode Binder,” Patent 10,483,546 B2, 2019. Li, Z. G. Wu, Y. M. Liu, Z. W. Yang, G. K. Wang, Y. X. Liu, Y. J. Zhong, Y. Song, B. H. Zhong, and X. D. Guo, Ionics (Kiel)., 27, 1829–1836 (2021). Figure 1

Представлены результаты моделирования пространственной структуры и электронных свойств кластеров MeGe16 - и MeGe20 - (Me = Sc, Y, Lu). Рассматривается возможность синтеза пуллереноподобных кластеров и кластеров с другими типами замкнутых структур. Проведены сравнительные расчеты в рамках теории функционала плотности с использованием базиса SDD и трех различных потенциалов – B3LYP, B3PW91 и PBEPBE. Анализируется влияние выбора потенциала на результаты моделирования пространственной структуры кластеров и их электронного спектра. Оценка адекватности теоретических методов проводится путем сравнения рассчитанных электронных спектров с экспериментальными результатами по фотоэлектронной спектроскопии кластеров. REFERENCES Kroto H. W., Heath J. R., O’Brien S. C., Curl R. F., Smalley R. E. C60: Buckminsterfullerene. Nature, 1985, v. 318, pp. 162-163. https://doi.org/10.1038/318162a0 Hiura H., Miyazaki, Kanayama T. Formation of Metal-Encapsulating Si Cage Clusters. Phys. Rev. Lett., 2001, v. 86, p. 1733. https://doi.org/10.1103/PhysRev-Lett.86.1733 Wang J., Han J. Geometries, stabilities, and electronic properties of different-sized ZrSin (n=1–16) clusters: A density-functional investigation. Chem. Phys., 2005, v. 123(6), pp. 064306–064321. https://doi.org/10.1063/1.1998887 Guo L.-J., Liu X., Zhao G.-F. Computational investigation of TiSin (n=2–15) clusters by the densityfunctional theory. Chem. Phys., 2007, v. 126(23), pp. 234704–234710. https://doi.org/10.1063/1.2743412 Li J., Wang G., Yao C., Mu Y., Wan J., Han M. Structures and magnetic properties of SinMn (n=1–15) clusters. Chem. Phys., 2009, v. 130(16), pp. 164514–164522. https://doi.org/10.1063/1.3123805 Borshch N. A., Berestnev K. S., Pereslavtseva N. S., Kurganskii S. I. Geometric structure and electron spectrum of YSi n− clusters (n = 6–17) Physics of the Solid State, 2014, v. 56(6), pp. 1276–1281. https://doi.org/10.1134/S1063783414060080 Borshch N., Kurganskii S. Geometric structure, electron-energy spectrum, and growth of anionic scandium-silicon clusters ScSin- (n = 6–20). Appl. Phys., 2014, v. 116(12), pp. 124302-1 – 124302-8. https://doi.org/10.1063/1.4896528 Borshch N. A., Pereslavtseva N. S., Kurganskii S. I. Spatial structure and electronic spectrum of TiSi n - Clusters (n = 6–18). Russian Journal of Physical Chemistry A, v. 88(10), pp. 1712–1718. https://doi.org/10.1134/S0036024414100070 Borshch N. A., Pereslavtseva N. S., Kurganskii S. I. Spatial and electronic structures of the germanium-tantalum clusters TaGe n − (n = 8–17). Physics of the Solid State, 2014, vol. 56(11), pp. 2336–2342. https://doi.org/10.1134/S1063783414110055 Huang X., Yang J. Probing structure, thermochemistry, electron affi nity, and magnetic moment of thulium-doped silicon clusters TmSi n (n = 3–10) and their anions with density functional theory. Mol. Model., 2018, v. 24(1), p. 29. https://doi.org/10.1007/s00894-017-3566-7 Zhang, Y., Yang, J., Cheng, L. J. Probing Structure, Thermochemistry, Electron Affi nity and Magnetic Moment of Erbium-Doped Silicon Clusters ErSin (n = 3–10) and Their Anions with Density Functional Theory. Sci., 2018, v. 29(2), pp. 301–311. https://doi.org/10.1007/s10876-018-1336-z Ye T., Luo C., Xu B., Zhang S., Song H., Li G. Probing the geometries and electronic properties of charged Zr2Si n q (n = 1–12, q = ±1) clusters. Chem., 2018, v. 29(1), pp. 139–146. https://doi.org/10.1007/s11224-17-1011-2 Nguyen M.T., Tran Q. T., Tran V.T. A CASSCF/ CASPT2 investigation on electron detachments from ScSi n − (n = 4–6) clusters. Mol. Model., 2017, v. 23(10), p. 282. https://doi.org/10.1007/s00894-017-3461-2 Liu Y., Jucai Yang J., Cheng L. Structural Stability and Evolution of Scandium-Doped Silicon Clusters: Evolution of Linked to Encapsulated Structures and Its Infl uence on the Prediction of Electron Affi nities for ScSin (n = 4–16) Clusters. Chem., 2018, v. 57(20), pp 12934–12940. https://doi.org/10.1021/acs.inorgchem.8b02159

With the ever-growing technology industry and the need for more sustainable energy, the race to develop better, more efficient, renewable materials for lithium ion batteries is at the forefront of research. Metal oxide materials for use as electrodes in lithium batteries have been promising in recent years, transition metal oxides are favourable due to their low cost and nanostructured metal oxides exhibit encouraging electrochemical properties.1-2 Photonic crystal structures, more specifically inverse opal (IO) structures, are porous, highly interconnected structures which have proven to have advantageous benefits such as increased surface area and lower ion diffusion distances.3 In this work we combine TiO2 and GeO2 in solution phase in two ratios, 2:1 and 5:1 in favour of TiO2. Titanium oxides have high working potentials, higher than graphite which is most commonly used today. TiO2 has previously shown excellent long life cyclability and has shown little structural strain during the lithiation/delithiation process.4 Germanium has a high theoretical capacity of 1384 mAh/g and high electrical conductivity however it is expensive for use as an anode.5 Previous reports have shown that by nano-structuring GeO2 into an inverse opal structure, it can behave like pure germanium during cycling beyond the initial reduction and lithitation cycles.6 By combining both materials, we were able to achieve high capacity values for both ratios, 3 times the capacity of titanium IOs on their own. Work is ongoing to investigate the optimal cost to benefit ratio of the TiO2/GeO2 composites. Initial capacity results showcase high capacity retention and voltage stability. Reddy, M. V.; Subba Rao, G. V.; Chowdari, B. V. R., Metal Oxides and Oxysalts as Anode Materials for Li Ion Batteries. Chemical Reviews 2013, 113 (7), 5364-5457. Wu, H. B.; Chen, J. S.; Hng, H. H.; Wen Lou, X., Nanostructured metal oxide-based materials as advanced anodes for lithium-ion batteries. Nanoscale 2012, 4 (8), 2526-2542. Armstrong, E.; O'Dwyer, C., Artificial opal photonic crystals and inverse opal structures – fundamentals and applications from optics to energy storage. Journal of Materials Chemistry C 2015, 3 (24), 6109-6143. McNulty, D.; Carroll, E.; O'Dwyer, C., Rutile TiO2 Inverse Opal Anodes for Li-Ion Batteries with Long Cycle Life, High-Rate Capability, and High Structural Stability. Advanced Energy Materials 2017, 7 (12), 1602291. Zhang, Q.; Chen, H.; Luo, L.; Zhao, B.; Luo, H.; Han, X.; Wang, J.; Wang, C.; Yang, Y.; Zhu, T.; Liu, M., Harnessing the concurrent reaction dynamics in active Si and Ge to achieve high performance lithium-ion batteries. Energy & Environmental Science 2018, 11 (3), 669-681. McNulty, D.; Geaney, H.; Buckley, D.; O'Dwyer, C., High capacity binder-free nanocrystalline GeO2 inverse opal anodes for Li-ion batteries with long cycle life and stable cell voltage. Nano Energy 2018, 43, 11-21. Figure 1. (a) SEM image of a TiO2/GeO2 inverse opal (b) SEM image of TiO2/GeO2 IOs with EDX mapping overlay indicating position of titanium (green) and germanium (red). (c) and (d) Charge discharge profiles at 150 mA/g for the first 100 cycles for the 2:1 ratio and 5:1 ratio respectively.(e) Rate capability test for both ratios with specific currents ranging from 75 mA/g-450 mA/g. Figure 1

В данной работе продемонстрирована возможность применения ИК-микроспектроскопии для многомерной визуализации и анализа интеграции с нативными твердыми тканями зуба человека нового поколения биомиметических материалов, воспроизводящих минералорганический комплекс эмали и дентина.На основе ИК-картирования интенсивности конкретной функциональной молекулярной группы с использованием синхротронного излучения найдены и визуализированы характеристические особенности биомиметического переходного слоя в межфазной области эмаль/стоматологический материал и определено расположение функциональных групп, отвечающих процессам интеграции биомиметического композита REFERENCES Rohr N., Fischer J. Tooth surface treatment strategies for adhesive cementation // The Journal of Advanced Prosthodontics, 2017, v. 9(2), pp. 85–92. https://doi.org/10.4047/jap.2017.9.2.85 Pereira C. N. de B., Daleprane B., Miranda G. L. P. de, Magalhães C. S. de, Moreira A. N. 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The investigations of changes in mineral–organic and carbon–phosphate ratios in the mixed saliva by synchrotron infrared spectroscopy // Results in Physics, 2016, v. 6, pp. 315–321. https://doi.org/10.1016/j.rinp.2016.06.005 Goloshchapov D. L., Kashkarov V. M., Rumyantseva N. A., Seredin P. V., Lenshin A. S., Agapov B. L., Domashevskaya E. P. Synthesis of nanocrystalline hydroxyapatite by precipitation using hen’s eggshell // Ceramics International, 2013, v. 39(4), pp. 4539–4549. https://doi.org/10.1016/j.ceramint.2012.11.050 Goloshchapov D. L., Lenshin A. S., Savchenko D. V., Seredin P.V. Importance of defect nanocrystalline calcium hydroxyapatite characteristics for developing the dental biomimetic composites // Results in Physics, 2019, v. 13, pp. 102158. https://doi.org/10.1016/j.rinp.2019.102158 Nanci A. Ten Cate’s Oral Histology: Development, Structure, and Function. 8th ed., Elsevier Health Sciences, 2013, 400 p. Ippolitov Ju. A. Vozmozhnost’ povyshenija biologicheskoj tropnosti svetootverzhdaemoj bondingovoj sistemy dlja adgezii tverdyh tkanej zuba k plombirovochnomu material [The possibility of increasing the biological tropism of the lightcuring bonding system for adhesion of hard tooth tissues to the filling material]. Volgogradskij nauchno-medicinskij zhurnal, 2010, v. 4 (28), pp. 31–34. URL: https://www.volgmed.ru/uploads/journals/articles/1293119124-bulletin-2010-4-815.pdf Seredin P., Goloshchapov D., Prutskij T., Ippolitov Y. Phase Transformations in a Human Tooth Tissue at the Initial Stage of Caries. PLoS ONE, 2015, v. 10(4), pp. 1–11. https://doi.org/10.1371/journal.pone.0124008 Seredin P. V., Goloshchapov D. L., Prutskij T., Ippolitov Yu. A. A Simultaneous Analysis of Microregions of Carious Dentin by the Methods of Laser- Induced Fluorescence and Raman Spectromicroscopy. Optics and Spectroscopy, 2018, v. 125(5), pp. 803–809. https://doi.org/10.1134/S0030400X18110267 Seredin P. V., Goloshchapov D. L., Prutskij T., Ippolitov Yu. A. Fabrication and characterisation of composites materials similar optically and in composition to native dental tissues. Results in Physics, 2017, v. 7, pp. 1086–1094. https://doi.org/10.1016/j.rinp.2017.02.025

A functioning hydrogen economy requires efficient ways of producing and utilizing hydrogen via electrolyzers and fuel cells. The commercialization of these devices is well underway but their considerable capital costs still inhibit faster adoption by society1,2. One pathway towards more inexpensive devices is by tackling their respective bottlenecks, the oxygen evolution and reduction reactions, which currently require catalyst materials comprised of scarce precious metals. Intensive research is being conducted to introduce and develop suitable replacements for these catalysts. In this field, non-platinum group metal (NPGM) type catalysts have gained significant attention2,3. We present several NPGM-type oxygen electrocatalysts synthesized by modifying peat-derived carbon with nitrogen and different combinations of transition metals (Fe, Co, Ni). The obtained catalysts were characterized with various methods to elucidate their structure-reactivity relations. Namely, SEM-EDS was used to confirm that the modification of peat-derived carbon was successful. Additionally, the various metal alloy species found in the catalysts were identified via X-ray diffraction analysis. The excellent bifunctional electrocatalytic activity of the peat-based materials towards oxygen evolution and reduction was confirmed with rotating disc electrode measurements conducted in a 0.1 M KOH solution. Correlations between the physical and electrochemical properties of the catalysts were established and analyzed. Acknowledgments This work was supported by the EU through the European Regional Development Fund under projects TK141 “Advanced materials and high-technology devices for energy recuperation systems” (2014-2020.4.01.15-0011), NAMUR “Nanomaterials - research and applications” (3.2.0304.12-0397), PRG676 “Development of express analysis methods for micro-mesoporous materials for Estonian peat derived carbon supercapacitors” (01.01.2020–31.12.2024) and PUT1581 (1.01.2017–31.12.2020). References E4tech, 2021, The Fuel Cell Industry Review 2020. C. Lei, S. Lyu, J. Si, B. Yang, Z. Li, L. Lei, Z. Wen, G. Wu, Y. Hou, ChemCatChem 2019, 11, 5855. L. Osmieri, J. Park, D. Cullen, P. Zelenay, D. Myers, K. Neyerlin, Curr Opin Electrochem 2021, 25, 100627. Figure 1

COVID-19 Pandemic resulted in social mobility and travel restrictions to contain the infection. It has been reported that there happened post-pandemic surge in the use of the internet and social media as people rely on it more often for entertainment, work, and learning purposes. It is also been used as an unhealthy coping strategy for pandemic related stress. The smartphone was found to be the most common gadget used for accessing internet-based services. Owing to the postural alterations related to the small screen size of smartphones, neck pain was reported very commonly among smartphone users. Neck pain among smartphone users is a public health concern needing immediate attention in the pandemic time. Many of the risk factors leading to neck pain among smartphone users are modifiable. The authors outline preventive strategies that are mostly self- regulated. The strategies recommended include reducing Smartphone usage time (Smartphone-Free Time, Smartphone-Free Zone), maintaining ideal posture (Focus Breaks, Mobility Breaks, How am I keeping my posture?, Hands-free alternatives), doing regular exercises, preparing and following an activity schedule, and inculcating healthy habits. References Sohrabi C, Alsafi Z, O’Neill N, Khan M, Kerwan A, Al-Jabir A, et al. World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). Int J Surg 2020; 76: 71–6. https://doi.org/10.1016/j.ijsu.2020.02.034 Király O, Potenza MN, Stein DJ, King DL, Hodgins DC, Saunders JB, et al. Preventing problematic internet use during the COVID-19 pandemic: Consensus guidance. Compr Psychiatry 2020; 100:152180. https://doi.org/10.1016/j.comppsych.2020.152180 Sun Y, Li Y, Bao Y, Meng S, Sun Y, Schumann G, et al. Brief Report: Increased Addictive Internet and Substance Use Behavior During the COVID‐19 Pandemic in China. Am J Addict 2020 ;29(4):268–70. https://doi.org/10.1111/ajad.13066 Varga E. How does the Internet Influences the Readers’ Behavior. Procedia Manuf. 2020; 46:949–56. https://doi.org/10.1016/j.promfg.2020.05.013 Zhuang L, Wang L, Xu D, Wang Z, Liang R. Association between excessive smartphone use and cervical disc degeneration in young patients suffering from chronic neck pain. J Orthop Sci. 2020; https://doi.org/1016/j.jos.2020.02.009 Davey S, Davey A. Assessment of smartphone addiction in indian adolescents: a mixed method study by systematic-review and meta-analysis approach. Int J Prev Med.2014;5(12):1500–11. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25709785 Smetaniuk P. A preliminary investigation into the prevalence and prediction of problematic cell phone use. J Behav Addict 2014 Mar;3(1):41–53. https://doi.org/1556/JBA.3.2014.004 Lee H, Seo MJ, Choi TY. The Effect of Home-based Daily Journal Writing in Korean Adolescents with Smartphone Addiction. J Korean Med Sci. 2016;31(5):764. https://doi.org/3346/jkms.2016.31.5.764 Yu S, Sussman S. Does Smartphone Addiction Fall on a Continuum of Addictive Behaviors? Int J Environ Res Public Health.2020;17(2):422. https://doi.org/10.3390/ijerph17020422.10. Kwon M, Kim D-J, Cho H, Yang S. The smartphone addiction scale: development and validation of a short version for adolescents. PLoS One2013;8(12): e83558. https://doi.org/1371/journal.pone.0083558 Ding D, Li J. Smartphone Overuse – A Growing Public Health Issue. J Psychol Psychother.2017;07(289):1-3. https://doi.org/0.4172/2161-0487.1000289 Boumosleh JM, Jaalouk D. Depression, anxiety, and smartphone addiction in university students- A cross sectional study. PLoS One 2017;12(8): e0182239. https://doi.org/1371/journal.pone.0182239 Xie Y, Szeto G, Dai J. Prevalence and risk factors associated with musculoskeletal complaints among users of mobile handheld devices: A systematic review. Appl Ergon.2017 Mar;59:132–42. https://doi.org/1016/j.apergo.2016.08.020 Alsalameh AM, Harisi MJ, Alduayji MA, Almutham AA, Mahmood FM. Evaluating the relationship between smartphone addiction/overuse and musculoskeletal pain among medical students at Qassim University. J Fam Med Prim care. 2019;8(9):2953–9. https://doi.org/4103/jfmpc.jfmpc_665_19 Toh SH, Coenen P, Howie EK, Smith AJ, Mukherjee S, Mackey DA, et al. A prospective longitudinal study of mobile touch screen device use and musculoskeletal symptoms and visual health in adolescents. Appl Ergon. 2020; 85:103028. https://doi.org/1016/j.apergo.2019.103028 Lee S, Kang H, Shin G. Head flexion angle while using a smartphone. Ergonomics. 2015 Feb 17;58(2):220–6. https://doi.org/1080/00140139.2014.967311 Guan X, Fan G, Chen Z, Zeng Y, Zhang H, Hu A, et al. Gender difference in mobile phone use and the impact of digital device exposure on neck posture. Ergonomics. 2016;59(11):1453–61. https://doi.org/10.1080/00140139.2016.1147614 Han H, Shin G. Head flexion angle when web-browsing and texting using a smartphone while walking. Appl Ergon. 2019; 81:102884. https://doi.org/1016/j.apergo.2019.102884 Singla D, Veqar Z. Association between forward head, rounded shoulders, and increased thoracic kyphosis: a review of the literature. J Chiropr Med. 2017;16(3):220–9. https://doi.org/1016/j.jcm.2017.03.004 Park J-H, Kang S-Y, Lee S-G, Jeon H-S. The effects of smart phone gaming duration on muscle activation and spinal posture: Pilot study. Physiother Theory Pract. 2017;33(8):661–9. https://doi.org/10.1080/09593985.2017.1328716 Xie Y, Szeto GPY, Dai J, Madeleine P. A comparison of muscle activity in using touchscreen smartphone among young people with and without chronic neck–shoulder pain. Ergonomics. 2016;59(1):61–72. https://doi.org/10.1080/00140139.2015.1056237 Hansraj KK. Assessment of stresses in the cervical spine caused by posture and position of the head. Surg Technol Int. 2014; 25:277–9. Li W, Yang Y, Liu Z-H, Zhao Y-J, Zhang Q, Zhang L, et al. Progression of mental health services during the COVID-19 outbreak in China. Int J Biol Sci. 2020;16(10):1732–8. https://doi.org/7150/ijbs.45120 Namwongsa S, Puntumetakul R, Neubert MS, Boucaut R. Factors associated with neck disorders among university student smartphone users. Work. 2018;61(3):367–78. https://doi.org/3233/WOR-182819 Ko P-H, Hwang Y-H, Liang H-W. Influence of smartphone use styles on typing performance and biomechanical exposure. Ergonomics. 2016;59(6):821–8. https://doi.org/10.1080/00140139.2015.1088075

Electrode formulation directly influences the resulting composite electrode structure and properties, ultimately impacting the electrode performance and durability. Although there have been many significant advancements in the development and understanding of novel and effective binder materials for silicon anodes1–4, few studies report more than one formulation, or ratio of active material to conductive additive to polymeric binder5,6. In this study, we focus on investigating the impact of polyimide binder weight ratio in silicon microparticle electrodes. Electrode adhesion to the current collector, cohesion, porosity, electrical resistivity, and electrical tortuosity were characterized in pristine electrodes. These properties were then correlated to electrode cycle life and rate performance in Si-NMC622 full cells. We show that there is an optimal binder weight ratio for a given type of polymer binder. Increasing binder weight ratio improves electrode adhesion and cohesion, resulting in improved cycle life. However, increased binder weight ratio decreases electrical conductivity and porosity, leading to poorer silicon particle utilization, capacity, and rate performance. In the formulations we investigated, the silicon to carbon weight ratio was fixed, while binder content was varied. The optimal binder ratio maximizes silicon particle utilization, achieving 1084 ± 25 mAh/gSi gravimetric capacity after the formation cycles. When binder content was increased three-fold, the discharge capacity decreased by 27%, which was correlated to lower electrode porosity and lower initial coulombic efficiency. We hypothesize that insufficient porosity limits lithium-ion access to the silicon particles, thus reducing the capacity at the given C-rate. We also hypothesize that the decreased coulombic efficiency indicates that the polyimide binder contributes to the consumption of available lithium. In contrast, capacity retention improved with additional binder content. This is partly due to increased electrode cohesion with the added binder and partly due to lower overall capacity in the silicon particles, resulting in less volumetric strain. In electrodes with the binder content reduced by one-third, capacity retention dropped dramatically. We hypothesize that there is a lower limit of binder content, below which the electrode lacks sufficient structural integrity to withstand volume strains during cycling. These findings point towards important design principles for the optimization of binder content in silicon electrode formulations. References: Mazouzi, D. et al. Critical roles of binders and formulation at multiscales of silicon-based composite electrodes. J. Power Sources 280, 533–549 (2015). Lopez, J., Mackanic, D. G., Cui, Y. & Bao, Z. Designing polymers for advanced battery chemistries. Nat. Rev. Mater. 4, 312–330 (2019). Kwon, T., Choi, J. W. & Coskun, A. The emerging era of supramolecular polymeric binders in silicon anodes. Chem. Soc. Rev. 47, 2145–2164 (2018). Yang, Y. et al. Towards efficient binders for silicon based lithium-ion battery anodes. Chem. Eng. J. 406, 126807 (2021). Park, S. J. et al. Side-chain conducting and phase-separated polymeric binders for high-performance silicon anodes in lithium-ion batteries. J. Am. Chem. Soc. 137, 2565–2571 (2015). Wilkes, B. N., Brown, Z. L., Krause, L. J., Triemert, M. & Obrovac, M. N. The Electrochemical Behavior of Polyimide Binders in Li and Na Cells. J. Electrochem. Soc. 163, A364–A372 (2016). Figure 1

В работе были проведены исследования возможности внедрения серебра в пористый кремний методом электро-термодиффузии и установлено влияние процедуры осаждения на адсорбционные свойства поверхности пористой матрицы. Композиты пористого кремния с внедренными частицами металла относятся к многофункциональным материалам и перспективны для применения в современной оптоэлектронике, сенсорике и персонализированной медицине. ИСТОЧНИК ФИНАНСИРОВАНИЯИсследование выполнено при поддержке РФФИ в рамках научного проекта 19-32-50038мол_нр «Исследование морфологических, физико-химических и оптических свойств матриц наоснове por-Si в зависимости от методов их формирования и функционализации». REFERENCES Raúl J. Martín-palma, Patrick D. McAtee, Rehab Ramadan, Akhlesh Lakhtakia. Hybrid nanostructured porous silicon-silver layers for wideband optical absorption. Scientifi c Reports, 2019, v. 9(1), p. 7291. https://doi.org/10.1038/s41598-019-43712-7 Kleps I., Miu M., Danila M., Simion M., Ignat T., Bragaru A., Dumitru L., Teodosiu G. Silver/porous silicon (PS) nanocomposite layers for biomedical applications. Proc. of “2006 International Semiconductor Conference”, 27-29 Sep., 2006, no. 9211112. https://doi.org/10.1109/SMICND.2006.283935 Ensafi A. A., Rezaloo F., Rezaei B. Electrochemical sensor based on porous silicon/silver nanocomposite for the determination of hydrogen peroxide. Sensors and Actuators B, 2016, v. 231, pp. 239–244. https://doi.org/10.1016/j.snb.2016.03.018 Jinjie Yin, Xiang Qi, Liwen Yang, Guolin Hao, Jun Li, Jianxin Zhong A hydrogen peroxide electrochemical sensor based on silver nanoparticles decorated silicon nanowire arrays. Electrochimica Acta, 2011, v. 56(11), pp. 3884–3889. https://doi.org/10.1016/j.electacta. 2011.02.033 Spivak Yu. M., Bespalova K. A., Belorus A. O., Panevin A. A., Somov P. A., Grigor’eva N. Yu., Chistyakova L. V., Zhuravskiy S. G., Moshnikov V. A. Sposob polucheniya i primer lekarstvennoy funktsionalizatsii poverkhnosti nanochastits poristogo kremniya [A method of obtaining and an example of drug functionalization of the surface of porous silicon nanoparticles]. Biotekhnosfera [Biotechnosphere], 2017 (3), pp. 69–75. (in Russ.) Pastukhov A. I., Belorus A. O., Bukina Ya. V., Spivak Yu. M., Moshnikov V. A. Infl uence of technology conditions on the surface energy of porous silicon using the method of contact angle. Proc. of “2017 IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering (EIConRus)”, 1–3 Feb., 2017, pp. 1183-1185. https://doi.org/10.1109/eiconrus.2017.7910770 Matyushkin L. B. Tekhnologiya i oborudovanie dlya polucheniya kolloidnykh kvantovykh tochek CsPbX3 (X = Cl, Br, I), CdSe/ZnS, plazmonnykh nanochastits Ag/SiO2 i gibridnykh struktur na ikh osnove [Technology and equipment for obtaining CsPbX3 colloidal quantum dots (X = Cl, Br, I), CdSe/ZnS, Ag/SiO2 plasmonic nanoparticles and hybrid structures based on them. Cand. Sci. (Eng.) diss. St. Petersburg, 2018, 138 p. URL: https://elibrary.ru/item.asp?id=35115356 (in Russ.) Permiakov N. V., Matyushkin L. B., Belorus A. O., Koshevoi V. L. Investigation of a program-controlled process of impregnation of porous semiconductors with silver nanoparticles to create an electrical contact. Proc. of “IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering (EIConRus)”, 2018, pp. 539–543. https://doi.org/10.1109/EICon- Rus.2018.8317154 Travkin P. G., Vorontsova N. V., Vysotsky S. A., Lenshin A. S., Spivak Yu. M., Moshnikov V. A. Issledovanie zakonomernostey formirovaniya struktury poristogo kremniya pri mnogostadiynykh rezhimakh elektrokhimicheskogo travleniya [Study of regularities of porous silicon structure formation with multistage modes of electrochemical etching]. Izvestiya SPBGETU LETI, 2011(4). pp. 3–9. (in Russ.) Belorus A. O., Komlev A. A. Certifi cate of state registration of computer programs No. 2014613394. Measurement of contact angle (MofCA) 26 March 2014. (in Russ.) Van Hoonacker A., Englebienne P. Revisiting silver nanoparticle chemical synthesis and stability by optical spectroscopy. Current Nanoscience, 2006, v. 2(4), pp. 359–371. https://doi.org/10.2174/157341306778699310 Girel K. V., Bondarenko A. V. Formirovanie nanostruktur serebra metodom immersionnogo osazhdeniya [Formation of silver nanostructures by immersion deposition method onto porous silicon and study of their optical properties]. Doklady BGUIR, 2014, v. 86(8), pp. 5–10. (in Russ.)

In this work, we investigate subluminal and superluminal light propagation in a vee-type three-level atomic medium under an external magnetic field. The dispersion and absorption behaviors are studied for the cases of absence and presence of a magnetic field. It is found that under an electromagnetically induced transparency condition, the light pulse can be switched between subluminal and superluminal propagation by ON-OFF switching of the magnetic field. Finally, the transient response of the medium is discussed, which shows that the considered scheme has potential applications in magneto-optic switching devices. Full Text: PDF ReferencesBoller K J, Imamoglu A, Harris S E, "Observation of electromagnetically induced transparency", Phys. Rev. Lett. 66 (1991) 2593. CrossRef Fleischhauer M, Imamoglu A, Marangos J P, "Electromagnetically induced transparency: Optics in coherent media", Rev. Mod. Phys. 77 (2005) 633. CrossRef L.V. Hau, S. E. Harris, Z. Dutton, C.H. Bejroozi, "Light speed reduction to 17 metres per second in an ultracold atomic gas", Nature, 397 (1999) 594. CrossRef Z. Dutton, N.G.C. Slowe, L.V. Hau, "The art of taming light: ultra-slow and stopped light", Europhysics News, 35 (2004) 33. CrossRef V. Bharti, V. Natarajan, "Sub- and super-luminal light propagation using a Rydberg state", Opt. Commun. 392 (2017) 180-184. CrossRef Khoa D X, Doai L V, Son D H and Bang N H, "Enhancement of self-Kerr nonlinearity via electromagnetically induced transparency in a five-level cascade system: an analytical approach", J. Opt. Soc. Am. B. 31 (2014) 1330. CrossRef Hamedi H R, Gharamaleki A H, and Sahrai M, "Colossal Kerr nonlinearity based on electromagnetically induced transparency in a five-level double-ladder atomic system", Appl. Opt 22 (2016) 5892. CrossRef A. Fountoulakis, A.F. Terzis, E. Paspalakis, "All-optical modulation based on electromagnetically induced transparency", Phys. Lett. A 374, (2010) 3354. CrossRef Khoa D X, Doai L V, Mai Anh L. N, Trung L. C, Thuan P. V, Dung N. T, and Bang N. H, J. "Optical bistability in a five-level cascade EIT medium: an analytical approach", Opt. Soc. Am. B, 33 (2016) 735. CrossRef Hoang Minh Dong, and Nguyen Huy Bang, "Controllable optical switching in a closed-loop three-level lambda system", Phy. Scr. 94, (2019) 115510. CrossRef Dong H M, Doai L V, Sau V N, Khoa D X and Bang N H, "Propagation of a laser pulse in a three-level cascade atomic medium under conditions of electromagnetically induced transparency", Photonics Letter of Poland, 3 (2016) 73. CrossRef Khoa D X, Dong H M, Doai L V and Bang N H, "Propagation of laser pulse in a three-level cascade inhomogeneously broadened medium under electromagnetically induced transparency conditions", Optik 131 (2017) 497. CrossRef H. M. Dong, L.V. Doai, and N.H. Bang, "Pulse propagation in an atomic medium under spontaneously generated coherence, incoherent pumping, and relative laser phase", Opt. Commun. 426 (2018) 553-557. CrossRef Jiahua Li, Rong Yu, Liugang Si, and Xiaoxue Yang, "Propagation of twin light pulses under magneto-optical switching operations in a four-level inverted-Y atomic medium", J. Phys. B: At. Mol. Opt. Phys. 43 (2010) 065502. CrossRef S. H. Asadpour, H. R. Soleimani, "Polarization dependence of optical bistability in the presence of external magnetic field", Opt. Commun 310 (2014) 120-124. CrossRef H.M. Dong, L.T.Y. Nga, and N.H. Bang, "Optical switching and bistability in a degenerated two-level atomic medium under an external magnetic field", App. Opt. 58, (2019) 4192. CrossRef H. M. Dong, L. T. Y. Nga, D. X. Khoa, N. H. Bang, "Controllable ultraslow optical solitons in a degenerated two-level atomic medium under EIT assisted by a magnetic field", Sci. Rep. 10 (2020) 15298. CrossRef Daniel A. Steck, "Rubidium 87D Line Data," http://steck.us/alkalidata. CrossRef

BackgroundImmune-mediated adverse events (imAE) commonly occur in patients treated with immune checkpoint inhibitors (ICI), and pneumonitis is known to occur in 3 -5 % of patients treated with anti-PD-1 / PD-L1 antibodies.1 Most cases are grade 1 or 2 events and can be treated with immunosuppression, but high-grade events occur in a minority of patients and can be fatal.2 Since lung inflammatory phenotypes, including fibrotic idiopathic interstitial pneumonias and infectious pneumonias, were associated with allelic variation in Human Leukocyte Antigen (HLA) genes,3 4 we hypothesized that HLA variants might also be a risk factor for ICI- associated pneumonitis.MethodsOut of 1761 atezolizumab (anti-PD-L1) treated patients across nine Genentech (GNE) clinical trials with available whole-genome sequencing data, 72 (4.1%) developed pneumonitis (table 1). We inferred HLA genotypes using HLA-HD5 and performed an association study including 87 alleles with a carrier frequency of >2%. In order to confirm our results, and to test whether the association is generalizable to different classes of ICI, we genotyped two additional cohorts using an Illumina genome-wide SNP array (GSA v3), followed by HLA imputation using HIBAG6: (1) 20 ICI-treated cancer patients with pneumonitis and 20 matched controls without from a pilot study on the AEROSMITH trial from Parker Institute for Cancer Immunotherapy (PICI); (2) 15 ICI-treated melanoma patients with pneumonitis and 149 without from Peter MacCallum Cancer Centre (PMC) (table 1).ResultsTwo HLA class II alleles that are part of a common haplotype showed significant associations with pneumonitis risk after multiple testing adjustment (HLA-DRB1*15:01, HLA-DQA1*01:02), with HLA-DRB1*15:01 showing the strongest association (p = 0.0002, odds ratio (OR) =2.51). No associations were identified in the control arms (N = 1192). In the PICI pilot cohort, HLA-DRB1*15:01 did not reach statistical significance in spite of a comparable OR (p = 0.26, OR = 2.75), but the allele was significantly associated with pneumonitis risk in the PMC cohort (p = 0.03, OR = 3.92). A meta-analysis across the three cohorts yielded a highly significant p-value of 1.2x10–5 (OR = 2.67, figure 1), suggesting that the association is generalizable across ICI. Importantly, the same class II haplotype was previously shown to be associated with diverse lung inflammatory, including fibrotic, phenotypes.3,4,7,8Abstract 811 Table 1Investigated cohortsAbstract 811 Figure 1Forest plot for HLA-DRB1*15:01 meta-analysis with ICI-associated pneumonitis. GNE, Genentech; PICI, Parker Institute for Cancer Immunotherapy; PMC, Peter MacCallum Cancer Centre; OR, odds ratio; CI, confidence interval; W, weight http://dx.doi.org/10.1136/jitc-2021-SITC2021.811ConclusionsIn summary, our findings establish HLA class II allelic variation as a potential risk factor in ICI-associated pneumonitis, and future research is warranted to determine whether this genetic association can be refined according to specific clinical presentations.ReferencesWang H, Guo X, Zhou J, Li Y, Duan L, Si X, et al. Clinical diagnosis and treatment of immune checkpoint inhibitor-associated pneumonitis. Thorac Cancer 2020;11:191–7.Naidoo J, Wang X, Woo KM, Iyriboz T, Halpenny D, Cunningham J, et al. Pneumonitis in patients treated with anti–programmed death-1/Programmed death ligand 1 therapy. J Clin Oncol 2016;35:709–17.Tian C, Hromatka BS, Kiefer AK, Eriksson N, Noble SM, Tung JY, et al. Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections. Nat Commun 2017;8:599.Fingerlin TE, Zhang W, Yang IV, Ainsworth HC, Russell PH, Blumhagen RZ, et al. Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia. BMC Genet 2016;17:74.Kawaguchi S, Higasa K, Shimizu M, Yamada R, Matsuda F. HLA-HD: An accurate HLA typing algorithm for next-generation sequencing data. Hum Mutat 2017;38:788–97.Zheng X, Shen J, Cox C, Wakefield JC, Ehm MG, Nelson MR, et al. HIBAG—HLA genotype imputation with attribute bagging. Pharmacogenomics J 2014;14:192–200.Voorter CEM, Drent M, Berg-Loonen EM van den. Severe pulmonary sarcoidosis is strongly associated with the haplotype HLA-DQB1*0602–DRB1*150101. Hum Immunol 2005;66:826–35.Furukawa H, Oka S, Shimada K, Sugii S, Ohashi J, Matsui T, et al. Association of human leukocyte antigen with interstitial lung disease in rheumatoid arthritis: a protective role for shared epitope. Plos One 2012;7:e33133.Ethics ApprovalPatients included in this study signed an optional Research Biosample Repository (RBR) Informed Consent Form (ICF) and provided whole blood samples. By signing the optional RBR ICF, patients provided informed consent for analysis of inherited and non-inherited genetic variation from whole blood samples. Ethics Committees (EC) and Institutional Review Boards (IRB) in each country and each study site for each clinical trial approved the clinical trial protocol, the main study ICF, and theRBR ICF.

This paper presents some results of rainfall forecast in the monsoon onset period in South Vietnam, with the use of ensemble Kalman filter to assimilate observation data into the initial field of the model. The study of rainfall forecasts are experimented at the time of Southern monsoon outbreaks for 3 years (2005, 2008 and 2009), corresponding to 18 cases. In each case, there are five trials, including satellite wind data assimilation, upper-air sounding data assimilation, mixed data (satellite wind+upper-air sounding data) assimilation and two controlled trials (one single predictive test and one multi-physical ensemble prediction), which is equivalent to 85 forecasts for one trial. Based on the statistical evaluation of 36 samples (18 meteorological stations and 18 trials), the results show that Kalman filter assimilates satellite wind data to forecast well rainfall at 48 hours and 72 hours ranges. With 24 hour forecasting period, upper-air sounding data assimilation and mixed data assimilation experiments predicted better rainfall than non-assimilation tests. The results of the assessment based on the phase prediction indicators also show that the ensemble Kalman filter assimilating satellite wind data and mixed data sets improve the rain forecasting capability of the model at 48 hours and 72 hour ranges, while the upper-air sounding data assimilation test produces satisfactory results at the 72 hour forecast range, and the multi-physical ensemble test predicted good rainfall at 24 hour and 48 hour forecasts. The results of this research initially lead to a new research approach, Kalman Filter Application that assimilates the existing observation data into input data of the model that can improve the quality of rainfall forecast in Southern Vietnam and overall country in general.References Bui Minh Tuan, Nguyen Minh Truong, 2013. 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Introduction: Bacteria of the genus Salmonella are important pathogens involved in the contamination of various foods, such as chickens, and may cause food poisoning. Aim: The present study aimed to review the literature on the prevalence of chickens contaminated with Salmonella spp., which are commercializated in different Brazilian states. Material and methods: This was a literary review. The absolute frequency and the total percentage of contaminated samples was calculated and the Qui-square statistical test was applied, considering statistically significant p <0.05. Results: 616 publications were retrieved, but only 10 articles were included to compose the results. The cataloged studies were carried out in 14 different brazilian states, and it was observed that of 5,030 chicken samples analyzed, the mean prevalence of samples contaminated with Salmonellawas 7,3% (n= 365). In addition, the prevalence of samples in the different studies ranged from 2.5% to 44.6%. The most prevalent serotype was S. Enteritidis (28,7%) and a statistically significant association between the type of raw material for commercialization and the result of the chicken samples microbiological analysis was observed (p<0.001), where the carcasses represented 90.1% of the contaminated samples. Conclusion: Thus, the data presented in this study can serve as subsidy for the development of necessary, political or legislative, measures that allow a better control of commercialized chickens in Brazil.Descriptors: Salmonella; Foodborne Diseases; Epidemiology.ReferencesSouza GC, Gonsalves HRO, Gonsalves HEO, Coêlho JLS. Característica microbiológica da carne de frango. ACSA. 2014;10(1):12-17.Pinto LAM, Pinto MM, Bovo J, Mateus GAP, Tavres FO, Baptista ATA, et al. Aspectos ambientais do abate de aves: uma revisão. Rev Uningá. 2018;22(3):44-50.Oliveira ME, Oliveira RLZ, Souza MFLZ, Harada ES, Tech ARB. Desenvolvimento de sensores para monitoramento de ambiente aviário com ênfase em controle térmico. Int J Agric & Biol Eng. 2018;12(3):234-40.Cintra APR, Andrade MCG, Lazarini MM, Assis DCS, Silva GR, Menezes LDM, et al. Influence of cutting room temperature on the microbiological quality of chicken breast meat. Arq Bras Med Vet Zootc. 2016;68(3):814-20.Rückert DAS, Pinto PSA, Santos BM, Moreira MAS, Rodrigues ACA. Pontos críticos de controle de Salmonella spp. no abate de frangos. Arq Bras Med Vet Zootec. 2009;61(2):326-30.Oliveira AP, Sola MC, Feistel JC, Moreira NM, Oliveira JJ. 2013. Salmonella enterica: genes de virulência e ilhas de patogenicidade. Enciclopedia Biosfera. 2013;9(16):1947-72.Brasil. Ministério da Saúde [homepage na internet]. Surtos de doenças transmitidas por alimentos no Brasil [acesso em 15 jul 2018]. Disponível em: http://portalarquivos2.saude.gov.br/images/pdf/2018/julho/02/Apresentacao-Surtos-DTA-Junho-2018.pdf.Borsoi A, Moraes HLS, Salle CTP, Nascimento VP. Número mais provável de Salmonella isoladas de carcaças de frango resfriadas. Ciênc Rural. 2010;40(11):2338-42.Cardoso KF, Rall VLM, Mendes AA, Paz ICLA, Komiyama CM. Pesquisa de salmonella e coliformes termotolerantes em cortes de frango obtidos no comércio de Botucatu/SP. Hig Aliment. 2009;23(176/179):165-68.Cunha-Neto AD, Carvalho LA, Carvalho RCT, Dos Prazeres Rodrigues D, Mano SB, Figueiredo EES, Conte-Junior CA. Salmonella isolated from chicken carcasses from a slaughterhouse in the state of Mato Grosso, Brazil: antibiotic resistance profile, serotyping, and characterization by repetitive sequence-based PCR system. Poult Sci. 2018;97(4):1373-81. Duarte DAM, Ribeiro AR, Vasconcelos AMM, Santos SB, Silva JVD, Andrade PLA, et al. Occurrence of Salmonella spp. in broiler chicken carcasses and their susceptibility to antimicrobial agents. Braz J Microbiol. 2009;40(3):569-73.Medeiros MA, Oliveira DC, Rodrigues DP, Freitas DR. Prevalence and antimicrobial resistance of Salmonella in chicken carcasses at retail in 15 Brazilian cities. Rev Panam Salud Publica. 2011;30(6):555-60.Menezes LDM, Lima AL, Pena EC, Silva GR, Klein RWT, Silva CA, et al. Caracterização microbiológica de carcaças de frangos de corte produzidas no estado de Minas Gerais. Arq Bras Med Vet Zootec. 2018;70(2):623-27.Moreira GN, Rezende CSM, Carvalho RN, Mesquita SQP, Oliveira AN, Arruda MLT. Ocorrência de Salmonella sp. em carcaças de frangos abatidose comercializados em municípios do estado de Goiás. Rev Inst Adolfo Lutz. 2008;67(2):126-30.Possebon FS, Costa LFZP, Yamatogi RS, Rodrigues MV, Sudano MJ, Pinto JPAN. A refrigeração no diagnóstico de Salmonella spp. utilizando o método microbiológico tradicional e reação em cadeia da polimerase em carcaças de frango. Ciênc Rural. 2012;42(1):131-35.Tessari ENC, Cardoso ALSP, Kanashiro AMI, Stoppa GFZ, Luciano RL, Castro AGM. Ocorrência de Salmonella spp. em carcaças de frangos industrialmente processadas procedentes de explorações industriais do Estado de São Paulo, Brasil. Cienc Rural, 2008; 38(9):2557-60.Yamatogi RS, Galvão JA, Baldini ED, Souza Júnior LCT, Rodrigues MV, Pinto JPAN. Avaliação da unidade analítica na detecção de Salmonella spp. em frangos a varejo. Rev Inst Adolfo Lutz. 2011;70(4):637-40.Sharma J, Kumar D, Hussain S, Pathak A, Shukla M, Kumar VP, et al. Prevalence, antimicrobial resistence and virulence genes characterization of montyphoidal Salmonella isolated from retail chicken meat shops in Northern India. Food Control. 2019;102:104-11.Harb A, Babib I, Mezal EH, Kareem HS, Laird T, O’dea M, et al. Ocurrence, antimicrobial resistence and whole-genome sequencing analysis of Salmonella isolates from chicken carcasses imported into Iraq from four different countries. Int J Food Microbiol. 2018;284:84-90.Zwe YH, Yentang VC, Aung KT, Gutiérrez RA, Ng LC, Yuk HG. Prevalence, sequence types, antibiotic resistance and, gyrA mutations of Salmonella isolated from retail fresh chicken meat in Singapore. Food Control. 2018;90:233-40.Goni AM, Effarizah ME, Rusul G. Prevalence, antimicrobial resistance, resistance genes and class 1 integrons of Salmonella serovars in leafy vegetables, chicken carcasses and related processing environments in Malaysian fresh food markets. Food Control. 2018;91:170-80.Zhu J, Wang Y, Song X, Cui S, Xu H, Yang B, et al. Prevalence and quantification of Salmonella contamination in raw chicken carcasses at the retail in China. Food Control. 2014;44:198-202.Kramarenko T, Nurmoja I, Karssin A, Meremae K., Horman A, Roasto M. The prevalence and serovar diversity of Salmonella in various food products in Estonia. Food Control. 2014;42:43-7.Smadi H, Sargeant JM, Shannon HS, Raina P. 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Res Vet Sci. 2015;101:63-8.Feasey NA, Hadfield J, Keddy KH, Dallman TJ, Jacobs J, Deng X, et al. Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings. Nat Genet. 2014;48(10):1211-17.

The pandemic of COVID-19 has afflicted every individual and has initiated a cascade of directly or indirectly involved events in precipitating mental health issues. The human species is a wanderer and hunter-gatherer by nature, and physical social distancing and nationwide lockdown have confined an individual to physical isolation. The present review article was conceived to address psychosocial and other issues and their aetiology related to the current pandemic of COVID-19. The elderly age group has most suffered the wrath of SARS-CoV-2, and social isolation as a preventive measure may further induce mental health issues. Animal model studies have demonstrated an inappropriate interacting endogenous neurotransmitter milieu of dopamine, serotonin, glutamate, and opioids, induced by social isolation that could probably lead to observable phenomena of deviant psychosocial behavior. Conflicting and manipulated information related to COVID-19 on social media has also been recognized as a global threat. Psychological stress during the current pandemic in frontline health care workers, migrant workers, children, and adolescents is also a serious concern. Mental health issues in the current situation could also be induced by being quarantined, uncertainty in business, jobs, economy, hampered academic activities, increased screen time on social media, and domestic violence incidences. The gravity of mental health issues associated with the pandemic of COVID-19 should be identified at the earliest. Mental health organization dedicated to current and future pandemics should be established along with Government policies addressing psychological issues to prevent and treat mental health issues need to be developed. References World Health Organization (WHO) Coronavirus Disease (COVID-19) Dashboard. 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ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Gengxu Li and Si Chen are co-first authors on ‘Matrix stiffness regulates α-TAT1-mediated acetylation of α-tubulin and promotes silica-induced epithelial–mesenchymal transition via DNA damage’, published in JCS. Gengxu is an undergraduate student in the lab of Fang Yang at Basic Medicine College, North China University of Science and Technology, China, and Si is a resident doctor at the Department of Neurosurgery, Tangshan People's Hospital, China, where they study the pathogenesis and prevention of lung fibrosis.

Penelitian ini dilakukan untuk menentukan sifat kimia fisik dari katalis abu sekam padi (ASP) termodifikasi litium oksida, optimasi suhu kalsinasi dalam sintesis katalis, serta menguji aktivitas katalitiknya dalam pembuatan biodiesel dari minyak biji malapari (Pongamia pinnata L.). Pembuatan katalis heterogen telah berhasil dilakukan melalui modifikasi ASP dengan litium karbonat. Modifikasi ASP dilakukan secara metode keramik melalui variasi suhu kalsinasi 700oC (Li-ASP700), 800oC (Li-ASP800), dan 900oC (Li-ASP900). Katalis heterogen yang diperoleh, dikarakterisasi, dan diuji aktivitasnya untuk pembuatan biodiesel dari minyak biji malapari. Karakterisasi katalis heterogen meliputi keasaman dan kebasaan permukaan, Brunauer, Emmett dan Teller (BET) surface area, gugus fungsional, dan rasio Li/Si. Hasil penelitian menunjukkan bahwa keasaman permukaan katalis Li-ASP700, Li-ASP800, dan Li-ASP900 semuanya adalah 0 mmol/g. Sementara, kebasaan permukaan tertinggi, surface area tertinggi, dan rasio Li/Si tertinggi diperoleh pada katalis Li-ASP700 berturut-turut yaitu 22,4883 mmol/g, 1,251 m2/g, dan 19,24. Oleh karena itu, suhu kalsinasi optimum dalam pembuatan katalis tersebut adalah 700oC. Katalis heterogen Li-ASP700 mampu mengkonversi minyak biji malapari menjadi biodiesel optimum pada persentase katalis 3% (b/b) dengan yield 87,29%. Kata kunci: abu sekam padi termodifikasi litium oksida, katalis heterogen, minyak biji malapari, biodiesel

Penelitian ini bertujuan untuk menganalisis keputusan konsumen dalam pembelian se-peda motor Suzuki di Yogyakarta. Sampel yang dijadikan obyek penelitian sebanyak 98 responden pengguna sepeda motor Suzuki di Yogyakarta. Pengambilan sampel dalam penelitian ini dilakukan dengan metode sampel non probabilitas yaitu Purposive Sam-pling. Teknik pengumpulan data dilakukan dengan cara menggunakan kuisioner. Se-dangkan teknik analisis yang digunakan dalam penelitian ini adalah analisis regresi li-nier berganda, dengan bantuan program SPSS versi 16,0. Hasil penelitian ini menun-jukkan bahwa berpengaruh terhadap keputusan pembelian baik secara simultan dan parsial. Ditunjukkan pada nilai faktor harga, kualitas, desain, dan kenyamanan, secara parsial mempunyai pengaruh yang positif dan signifikan terhadap keputusan pembe-lian, dibuktikan dengan nilai t masing-masing sebesar 3,239(X1); 2,245(X2); 1,999(X3); 4,530(X5) dan nilai signifikansi yang kurang dari 0,05 masing-masing sebesar 0,002(X1); 0,026(X2); 0,048(X3) dan 0,000(X5). Variabel faktor kemudahan perawatan tidak memiliki pengaruh yang signifikan karena t sebesar 0,153 dengan nilai signifikan-si 0,879 > 0,05. Hasil Uji F dengan nilai Fhitung 37.664 dan signifikansi 0,000. Hasil ini membuktikan bahwa secara bersama-sama faktor harga, kualitas, desain, kemudahan perawatan dan kenyamanan berpengaruh terhadap keputusan pembelian. Dari hasil pengujian koefisien determinasi nilai R = 0,820 menunjukkan mempunyai hubungan yang kuat terhadap keputusan pembelian. Sedangkan nilai Adjusted R2 sebesar 0,654 hal ini berarti sebesar 65,4% menyumbangkan perubahan variabel X terhadap Y dan si-sanya 34,6% tidak dijelaskan atau dipengaruhi oleh variabel lain yang tidak dimasuk-kan dalam model penelitian ini.

Introduction: Uremic pruritus is common in dialysis patients and reduces their quality of life. Chinese herbal medicine has been effective in patients with this condition.Methods: We conducted a random-effects network meta-analysis to compare the efficacies of different Chinese herbal medicine treatments for uremic pruritus. Outcome measures including the overall effective rates, visual analog scale scores, C-reactive protein levels, and adverse drug reactions were analyzed.Results: The network meta-analysis retrieved 25 randomized controlled trials. Compared with conventional treatments alone, combination treatments with Xiao-Yang-Ke-Li was the most effective intervention in decreasing visual analog scale scores (mean difference −2.98, 95% mean difference −5.05 to −0.91) and levels of C-reactive protein (mean difference −5.01, 95% mean difference −7.27 to −2.75). Conventional treatment combined with Si-Wu Tang was superior to other therapeutic combinations when overall effective rates were determined. The best visual analog scale scores and overall effective rates were achieved by adjunctive treatment with the Touxie-Jiedu-Zhiyang decoction followed by uremic clearance granules; these treatments were the most beneficial for uremic pruritis.Conclusion: Our network meta-analysis provided the relative efficacies of different adjunctive Chinese herbal formulas. Adjunctive treatment with the Touxie-Jiedu-Zhiyang decoction was the best treatment for improving overall effective rates and reducing visual analog scores of uremic pruritus in dialysis patients.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=357656; Identifier: CRD42022357656.

Abstract: The Qur'an is actually a holy book that contains moral teachings to guide man to the straight path. Only, when the Qur'an in consumption by the public, the book is undergoing a paradigm shift so treated, diresepsi, and expressed vary according to the knowledge and belief respectively. The expression, of a concrete indicator that the Koran is a holy book that is always in tune with the situation and the condition (s}a>lih{ li kulli zama>n wa maka>n). The reception-style models and even now continues to be expressed and preserved by a large family of Miftahul Huda Islamic Boarding School Rawalo Banyumas. This study aims to find out the reception of the Qur'an in the boarding school, as well as trying to understand the meaning inherent in it. This study was designed with qualitative method and included in the research field. In obtaining the data, the researchers use an instrument that is in-depth interviews, observation, and study of the relevant documents. The analysis used by researchers is, as submitted by Mohd. Soehadha, ie the reduction of data, display of data, and conclusion. In clarifying the validity of the data, researchers conducted the extension of participation, and triangulation of sources and methods. From the research conducted, the results obtained are: (1) diversity reception of the Qur'an in Miftahul Huda Islamic Boarding School Rawalo Banyumas, among others: (a) reception exegesis of the Qur'an in the recitation Book Jalalain; (b) the aesthetic reception of the Qur'an contained in calligraphy at the hostel students and ndalem caregivers; (c) functional reception of the Qur'an manifested in the tradition of the reading of Al-Wa> qi'ah and Ya>si>n; and (d) reception eternalitas Qur'an embodied in various practices of preservation of the Qur'an, such as deposit bi al-naz{ri and bi al-hifz{i, sima'an, and mura> ja'ah. (2) The meanings inherent in the diversity reception, among others: objective meaning, the meaning of expressive and documentary meaning. Objective meaning conclude that behavioral diversity reception in the boarding school is as a symbol of obedience and reverence to the rules cottage. Expressive meaning is as a form of internalization yourself with positive things through the process of learning the Qur'an continuity and meaning to his documentary is a form of local contextualization of the cultural system overall.Keywords: Reception, Al-Quran and Miftahul Huda Islamic Boarding school.Abstrak: Al-Qur’an sejatinya merupakan kitab suci yang berisi ajaran-ajaran moral sebagai huda—petunjuk—bagi manusia ke jalan yang benar. Hanya saja, ketika Al-Qur’an sampai dan dikonsumsi oleh masyarakat, kitab suci tersebut mengalami pergeseran paradigma sehingga diperlakukan, diresepsi, dan diekspresikan secara berbeda-beda sesuai dengan pengetahuan dan ideologinya masing-masing. Fenomena tersebut nampaknya dapat dijadikan indikator konkret bahwasannya Al-Qur’an merupakan kitab suci yang senantiasa relevan dengan segala situasi dan kondisi (s}a>lih{ li kulli zama>n wa maka>n). Ragam resepsi tersebut bahkan kini terus diekspresikan dan dilestarikan oleh keluarga besar Pondok Pesantren—kemudian disebut Ponpes—Miftahul Huda Rawalo Banyumas. Penelitian ini bertujuan untuk mengetahui ragam resepsi Al-Qur’an di Ponpes tersebut, serta berusaha memahami makna yang melekat di dalamnya. Penelitian ini dirancang dengan menggunakan metode kualitatif dan termasuk dalam jenis penelitian lapangan (field research). Dalam memperoleh data, peneliti menggunakan berbagai instrument, seperti wawancara, observasi, dan dokumentasi atau studi atas dokumen terkait. Analisis yang peneliti gunakan adalah sebagaimana yang disampaikan Mohd. Soehadha, yaitu dengan reduksi data, display data, dan penarikan kesimpulan. Di dalam mengklarifikasi keabsahan data, peneliti melakukan perpanjangan keikutsertaan, serta triangulasi sumber maupun metode. Dari penelitian yang dilakukan, menunjukkan bahwa: (1) ragam resepsi Al-Qur’an yang ada di Ponpes tersebut antara lain: (a) resepsi eksegesis; (b) resepsi estetis; (c) resepsi fungsional; dan (d) resepsi eternal. Resepsi eksegesis mewujud dalam kajian kitab tafsir Jalalain, resepsi estetis mewujud dalam kaligrafi di asrama dan ndalem pengasuh, resepsi fungsional mewujud dalam pembacaan surat-surat “idaman,” dan resepsi eternal terejawantahkan dalam pelbagai praktik preservasi Al-Qur’an, seperti setoran bi al-naz{ri dan bi al-ghaib, sima’an, dan mura>ja’ah. (2) Makna-makna yang melekat dalam ragam resepsi tersebut, antara lain: makna objektif, makna ekspresif, dan makna dokumenter. Makna objektif menyimpulkan bahwa ragam perilaku resepsi di ponpes tersebut adalah sebagai simbolisasi kepatuhan dan ketakziman terhadap peraturan pondok. Makna ekspresifnya adalah sebagai wujud internalisasi diri dengan hal-hal positif melalui proses pembelajaran Al-Qur’an yang berkelanjutan, dan makna dokumenternya adalah sebagai bentuk kontekstualisasi lokal dari sistem kebudayaan yang menyeluruh.Kata Kunci: Resepsi, Al-Qur’an, dan Ponpes Miftahul Huda Banyumas.

Graphene-based composites have received a great deal of attention in recent year because the presence of graphene can enhance the conductivity, strength of bulk materials and help create composites with superior qualities. Moreover, the incorporation of metal oxide nanoparticles such as Fe3O4 can improve the catalytic efficiency of composite material. In this work, we have synthesized a composite material with the combination of reduced graphene oxide (rGO), and Fe3O4 modified tissue-paper (mGO-PP) via a simple hydrothermal method, which improved the removal efficiency of the of methylene blue (MB) in water. MB blue is used as the model of contaminant to evaluate the catalytic efficiency of synthesized material by using a Fenton-like reaction. The obtained materials were characterized by SEM, XRD. The removal of materials with methylene blue is investigated by UV-VIS spectroscopy, and the result shows that mGO-PP composite is the potential composite for the color removed which has the removal efficiency reaching 65% in acetate buffer pH = 3 with the optimal time is 7 h. Keywords Graphene-based composite, methylene blue, Fenton-like reaction. References [1] Ma Joshi, Rue Bansal, Reng Purwar, Colour removal from textile effluents, Indian Journal of Fibre & Textile Research, 29 (2004) 239-259 http://nopr.niscair.res.in/handle/123456789/24631.[2] Kannan Nagar, Sundaram Mariappan, Kinetics and mechanism of removal of methylene blue by adsorption on various carbons-a comparative study, Dyes and pigments, 51 (2001) 25-40 https://doi.org/10.1016/S0143-7208(01)00056-0.[3] K Rastogi, J. N Sahu, B. C Meikap, M. 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This study uses an in silico screening docking model to evaluate the ACE2 inhibitory activity of natural compounds and drugs. The study collected 49 compounds and evaluated the ACE2 inhibitory effect in silico. The study results show that 11 out of the 49 compounds had stronger inhibitory activity on ACE2 than MLN-4760. Lipinski’s rule of five criteria and predictive pharmacokinetic-toxicity analysis show that eight compounds including quercetin, galangin, quisinostat, fluprofylline, spirofylline, RS 504393, TNP and GNF-5 had drug-likeness. These compounds could be potential drug for the Covid-19 treatment. Keywords SARS-CoV-2S, Covid-19, ACE2, molecular docking, in silico. References [[1] C. Wang, P.W. Horby, F.G. Hayden, G.F. Gao. A novel coronavirus outbreak of global health concern. The Lancet 395(10223) (2020) 470.[2] WHO. WHO Coronavirus Disease (COVID-19) Dashboard. WHO, 2020.[3] N. Chen, M. Zhou, X. Dong, J. Qu, F. Gong, Y. Han, et al. 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Mohd Gazzali, H.A. Wahab. Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2. Molecules 25(17) (2020) 3980.[18] M.J. Huentelman, J. Zubcevic, J.A. Hernández Prada, X. Xiao, D.S. Dimitrov, M.K. Raizada, et al. Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor. Hypertension (Dallas, Tex : 1979) 44(6) (2004) 903.[19] S. Choudhary, Y.S. Malik, S. Tomar. Identification of SARS-CoV-2 Cell Entry Inhibitors by Drug Repurposing Using in silico Structure-Based Virtual Screening Approach. Front Immunol 11((2020) 1664.[20] C.A. Lipinski. Lead-and drug-like compounds: the rule-of-five revolution. Drug Discovery Today: Technologies 1(4) (2004) 337.[21] B. Jayaram, T. Singh, G. Mukherjee, A. Mathur, S. Shekhar, V. Shekhar, Eds. Sanjeevini: a freely accessible web-server for target directed lead molecule discovery. Proceedings of the BMC bioinformatics; 2012. Springer (Year).[22] D.E. Pires, T.L. Blundell, D.B. 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