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Relevant bibliographies by topics / Sida acuta

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Academic literature on the topic 'Sida acuta'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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Journal articles on the topic "Sida acuta"

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Kanta Kanthal, Lakshmi. "EVALUATION OF IN-VITRO CYTOTOXIC ACTIVITY OF CHLOROFORM EXTRACT OF SIDA ACUTA BURM.F." Asian Journal of Pharmaceutical and Clinical Research 10, no. 2 (February 1, 2017): 143. http://dx.doi.org/10.22159/ajpcr.2017.v10i2.14810.

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ABSTRACTObjective: The aim of the present work was to investigate the in-vitro cytotoxic activity of chloroform extract of Sida acuta Burm.f.Methods: The in-vitro cytotoxic activity of chloroform extract was performed by MTT assay method against A-431 (Human epidermoid carcinoma) and HeLa (Human cervical cancer) cell lines.Results: The various concentration of crude chloroform extract (1000, 500, 250, 125, 62.5 µg/ml concentration) of Sida acuta whole plant was performed for cytotoxic activity. Effect of inhibition of cell growth showed significantly cytotoxic against A-431 cell lines (human epidermoid carcinoma) with an of 375±0.00 and HeLa cell lines (human cervix carcinoma with an IC50 (inhibit cell growth by 50%) 610.00±2.5. The results obtained from the study indicate significant cytotoxic activity. The result of anticancer activity study in cell lines of the extract indicates that Sida acuta has anticancer activity against A-431-Human epidermoid carcinoma, HeLa-Human cervical cancer cell lines.Conclusion: The present study concluded that the chloroform extract of Sida acuta Burm.f. posses potent cytotoxic activity.Keywords: Sida acuta Burm.f., Chloroform extract, Cytotoxic activity, IC50.

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Sreedevi, C. D., P. G. Latha, P. Ancy, S. R. Suja, S. Shyamal, V. J. Shine, S. Sini, G. I. Anuja, and S. Rajasekharan. "Hepatoprotective studies on Sida acuta Burm. f." Journal of Ethnopharmacology 124, no. 2 (July 2009): 171–75. http://dx.doi.org/10.1016/j.jep.2009.04.055.

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Krapovickas, Antonio. "Sida sección Distichifolia (Monteiro) Krapov. comb, nov., stat. nov. (Malvaceae-Malveae)." Bonplandia 12, no. 1-4 (January 1, 2003): 83. http://dx.doi.org/10.30972/bon.121-41407.

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<div>Se revisa el complejo Sida acuta. Se propone ¡a nueva sección Distichifolia (Monteiro) Krapov.</div><div>del género Sida. Se reconocen 15 especies de las cuales S. Hatschbachii y S. Reitzii del SE de</div><div>Brasil se describen como nuevas. S. Lechleri es un nuevo nombre para S. acuta var. hispida</div><div>de Perú y S. cuspidata es una nueva combinación basada en S. acuta var. cuspidata de</div><div>México y Centro América</div>

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Monsurat M., Raimi,, Oyekanmi, Adeyinka M., and Adegoke, Bosede M. "Proximate, Phytochemical and Micronutrient Composition of Sida acuta." IOSR Journal of Applied Chemistry 7, no. 2 (2014): 93–98. http://dx.doi.org/10.9790/5736-07219398.

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Benjumea, Dora M., Isabel C. Gómez-Betancur, Julieta Vásquez, Fernando Alzate, Andrea García-Silva, and José A. Fontenla. "Neuropharmacological effects of the ethanolic extract of Sida acuta." Revista Brasileira de Farmacognosia 26, no. 2 (March 2016): 209–15. http://dx.doi.org/10.1016/j.bjp.2015.09.011.

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Semwal, Alok, and M. Senthil Kumar. "Development of quality control parameters for the standardization of Leaves and bark of Sida acuta Burm.f." Indian Journal of Pharmaceutical and Biological Research 2, no. 04 (December 31, 2014): 89–93. http://dx.doi.org/10.30750/ijpbr.2.4.15.

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Sidha acuta Burm. f belonging to family Malvaceae is a terrestrial, erect shrub which is up to 155 cm tall. The plant is native to Mexico, Central America and Himalayan region of India but has spread throughout the tropics and subtropics. Sida acuta Burm. f is widely distributed in pantropical areas and is widely used as traditional medicine in many cases. Among illnesses the plant is may be used alone or in combinations with other plants to cure fever, skin diseases, snake bites, Hemorrhoids, impotency and for boils and eye cataracts. Although the plant has been screened and suggested for various therapeutic activities its photocomposition remained unrevealed because of very restricted amount of research work carried out. Thus it was thought worthwhile to explore this endangered plant on the basis of various standardization parameters. The present research work deals with the collection, identification, extraction, pharmacognosical and phytochemical investigation of Leaves of Sidha acuta Burm. f.

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Perumalsamy Muneeswari, Sri Rashmy Madathi, and Kannappan Poornima. "Acute and Sub chronic Toxicological evaluation of ethanolic leaf extract of Sida acuta Burm.F in Wistar albino rats by analyzing biochemical, heamatological and histochemical parameters." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (July 24, 2020): 4111–19. http://dx.doi.org/10.26452/ijrps.v11i3.2614.

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Sida acuta burm.f belongs to Malvaceae, the mallow family and enjoys tropical and pantropical distribution. The plant is usually known as wireweed in the countryside, and it is highly medicinally valued traditionally and ethnobotanically promised. The species have literature reports on scientific attributes like abortifacient, anthelmintic, diuretic, anti-rheumatic, antipyretic and wound healing properties. The present study is concerned with acute and sub-chronic toxicity evaluation of ethanolic extract of Sida acuta Burm.f leaves in Wistar albino rats. Acute toxicity evaluation was conducted for 14 days. Acute doses of 100, 250, 500, 1000 and 2000 mg/kg BW were administrated to test groups of animals under consideration on the first day of experimental evaluation with three animals in each of total six groups along with control. For the remaining 13 days, animals were observed for noted behavioural changes and body weight were recorded respectively for 7th and 14th day of experimental analysis. At the end of the trial period, all the animals were euthanised, and various biochemical parameters and histopathological examination were carried out to assess the toxicity of extract. The present study revealed that the ethanolic extract of Sida acuta Burm.f leaves is non-toxic up to 2000mg/kg body weight. Subchronic toxicity evaluation was conducted for 28 days with several doses 100, 200, 300, 400 and 500mg/kg BW. Control rats without any treatment were maintained during the entire period of experimental analysis. The results of subchronic toxicity parameters indicate no significant changes to the biochemical parameters (glucose, urea, uric acid, creatinine, AST, ALT and Cholesterol) haematological and histopathological observation in comparison to the control groups. Based on subchronic toxicity parameters data, effective doses (200 and 400mg/kg BW) is determined for further cancer (colon) study in Wistar albino rats.

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Obeten, Kebe, E., Ettah, E. Nkanu, and Gabriel U. Udo-Affah. "HISTO-HORMONAL STUDIES OF THE EFFECT OF Sida acuta ON THE TESTIS OF ADULT WISTAR RATS." International Journal of Anatomy and Research 7, no. 2.1 (April 5, 2019): 6424–31. http://dx.doi.org/10.16965/ijar.2019.133.

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Jyostna Kumari T, Penchala Pratap G, Murthy P H C, and Goli Penchala Prasad. "Pharmacognostical standardization of balamula churna (Sida acuta Burm.f. root powder)." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (January 7, 2020): 160–65. http://dx.doi.org/10.26452/ijrps.v11i1.1801.

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In this study, an effort was performed to produce the data on, physicochemical parameters, preliminary phytochemical screening, histochemical studies, and HPTLC data required for the standardization of Balamula Churna concerning root powder of Sida acuta. The physicochemical parameters such as water-soluble extractive, alcohol soluble extractive, and loss on drying at 105 °C, total ash, and insoluble acid ash were determined according to standard methods. HPTLC studies were carried, and Rf values were documented. Physicochemical parameter values were recorded as pH (6.73 LOD (114.2gms) water-soluble extractive value (4.48%), alcohol soluble extractive value 6.88%) total Ash (11.00%) and Acid Insoluble Ash (2.72%). Preliminary phytochemical screening reveals the presence of glycoside, alkaloid, carbohydrate, phenol, flavonoid, and saponin. HPTLC screening showed the occurrence of significant phytoconstituents with Rf values 0.07, 0.21, 0.54, and 0.86. The obtained results from this study can be effective in the evaluation of quality, detection of adulteration and substitution, and highlighting the importance of standardization

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E Obeten, Kebe, Victor A Fische, Gabriel Udo-Affah, and Etah E Nkanu. "Prostatic Study of Extract of Sida Acuta on Wistar Rats." Acta Scientific Pharmaceutical Sciences 3, no. 8 (July 11, 2019): 29–33. http://dx.doi.org/10.31080/asps.2019.03.0337.

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Dissertations / Theses on the topic "Sida acuta"

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Al-Aqeel, Hamed Adnan. "Characterization of two begomoviruses isolated from Sida santaremensis Monteiro and Sida acuta Burm. f." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0002838.

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Amaral, Josiane Gonçalves. "Estudo da transmissão de begomovírus via semente em Sida spp." Universidade Federal de Viçosa, 2016. http://www.locus.ufv.br/handle/123456789/9491.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
A família Geminiviridae é composta por vírus com genoma de DNA circular de fita simples, encapsidado por uma única proteína estrutural em partículas icosaédricas geminadas. A família é dividida em sete gêneros com base no tipo de inseto vetor, gama de hospedeiros, organização genômica e relacionamento filogenético. Os vírus pertencentes ao gênero Begomovirus possuem um ou dois componentes genômicos e são transmitidos pela mosca-branca Bemisia tabaci a plantas dicotiledôneas. Os begomovírus infectam naturalmente diversas espécies de plantas não-cultivadas, como Sida spp. e Macroptilium spp. Estes hospedeiros não-cultivados podem abrigar populações virais com uma maior diversidade genética. Entretanto, algumas populações virais parecem estar confinadas em determinadas espécies de plantas não-cultivadas. Com base na observação de plantas não-cultivadas emergindo no campo com sintomas de infecção por begomovírus, aparentemente na ausência do inseto vetor, e em relatos recentes de transmissão de begomovírus via semente em batata-doce, feijoeiro e tomateiro, este estudo teve como objetivo analisar a presença de begomovírus em sementes de Sida acuta e Sida rhombifolia, bem como a transmissão desses vírus via semente. Um total de 39 plantas dessas duas espécies, apresentando sintomas típicos da infecção por begomovírus, foram coletadas em Viçosa, MG, em dezembro de 2013, e transferidas para casa-de-vegetação. A infecção viral foi confirmada em 38 plantas por meio de extração de DNA total de tecido foliar seguido de amplificação por círculo rolante (rolling-circle amplification, RCA). Os produtos da amplificação foram clonados e sequenciados, confirmando-se a infecção pelo Sida yellow mosaic virus (SiYMV) nas plantas de S. rhombifolia e pelo Sida yellow leaf curl virus (SiYLCV) nas plantas de S. acuta. Aproximadamente 320 mil sementes foram coletadas das 38 plantas infectadas. As sementes foram tratadas superficialmente com hipoclorito de sódio ou com ácido sulfúrico e foram maceradas em grupos de 20, 30 ou 200 sementes. O DNA total extraído de aproximadamente 80 mil sementes foi utilizado para detecção viral via RCA, com resultados negativos. DNA total foi extraído também de flores inteiras e de tecidos florais (sépalas, pétalas, estames, estiletes e ovários) das plantas infectadas, e utilizado para detecção viral com resultados positivos em todos os casos. Sementes proveniente das plantas infectadas foram tratadas com ácido sulfúrico, germinadas e 269 plântulas provenientes dessas sementes foram avaliadas para a presença dos vírus via RCA e PCR, com resultados negativos. Em conjunto, os resultados indicam que o SiYMV e o SiYLCV são capazes de infectar os tecidos florais de Sida rhombifolia e de Sida acuta, respectivamente, entretanto não são transmitidos pelas sementes desses hospedeiros.
The family Geminiviridae is comprised of viruses with a circular, single-stranded DNA genome encapsidated by a single structural protein in geminate, icosahedral particles. The family is divided into seven genera base on the type of insect vector, host range, genomic organization and phylogeny. Viruses classified in the genus Begomovirus have one or two genomic components and are transmitted in nature by the whitefly Bemisia tabaci to dicot plants. Begomoviruses naturally infect several non-cultivated hosts, such as Sida spp. and Macroptilium spp. These non-cultivated hosts may harbor viral populations with a high degree of genetic diversity. Nevertheless, some viral populations seem to be confined to certain species of non- cultivated plants. Based on the observation of non-cultivated plants newly emerged in the field already showing symtpoms of begomovirus infection, apparently in the absence of the insect vector, and on recent reports of seed transmission of begomoviruses in sweet potato, bean and tomato, the objective of this study was to analyze the presence of begomoviruses in seeds of Sida acuta and Sida rhombifolia, as well as the transmission of these viruses by seed. A total of 39 plants of these two species, displaying typical symptoms of infection by begomoviruses, were collected in Viçosa, MG, on December 2013, and transferred to a greenhouse. Viral infection was confirmed in 38 of these plants by total DNA extraction followed by rolling- circle amplification (RCA) of complete viral genomes. Amplification products were cloned and sequenced, confirming infection of S. rhombifolia by Sida yellow mosaic virus (SiYMV) and of S. acuta by Sida yellow leaf curl virus (SiYLCV). Approximately 320,000 seeds were collected from the 38 infected plants. The seeds were surface-sterilized with sodium hypochloride or sulphuric acid, and were ground in groups of 20, 30 or 200 seeds. Total DNA extracted from approximately 80,000 seeds was used for viral detection by RCA, with negative results. Total DNA was also extracted from whole flowers and from flower tissues (sepals, petals, stamens, styles and ovaries) from infected plants and used for viral detection, with positive results in all cases. Seeds from infected plants were treated with sulphuric acid, germinated and 269 plantlets from these seeds were evaluated for the presence of virus by RCA and PCR, with negative results. Together, these results indicate that SiYMV and SiYLCV are capable of infecting the flower tissues of Sida rhombifolia and Sida acuta, respectively, however they are not transmitted by seeds in these hosts.

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Wang, Tingrong. "Experimental acute tubulointerstitial disease caused by cimetidine." Virtual Press, 1993. http://liblink.bsu.edu/uhtbin/catkey/879842.

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Cimetidine is a histamine H2-receptor antagonist that is among the most widely prescribed drugs in the world. In addition to its inhibitory action on gastric acid secretion, a possible role in kidney tubulointerstitial disease has been suggested. Isolated reports have also suggested an association between cimetidine administration and acute interstitial nephritis. The present study examined the effect of cimetidine on renal function in the rat. The nine rats used in this study had normal renal function and urinalyses before treatment with cimetidine. The cimetidine treated rats then developed a clinical picture of weakness, hematuria, proteinuria, casturia, oliguria, and increases in serum blood urea nitrogen and creatinine.Following the 6 weeks treatment period, all rats were sacrificed and their kidneys prepared for microscopic study. Histologically, the patchy, intense tubulointerstitial infiltration of lymphocytes, plasma cells, and other cells observed in the cortex of the rat kidneys is quite similar to findings described in human cases of drug-induce hypersensitivity tubulointerstitial disease. In addition, other pathologic conditions which can cause tubulointerstitial disease were adequately ruled out. Specifically, bacterial pyelonephritis was excluded as a result of the consistently sterile urine test. In conclusion, the author feels that the clinical, aboratory, and histologic findings in this study strongly suggests an association between of tubulointerstitial disease and the use of cimetidine.
Department of Physiology and Health Science

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Togo, Masaya. "Short “Infraslow” Activity (SISA) With Burst Suppression in Acute Anoxic Encephalopathy: A Rare, Specific Ominous Sign With Acute Posthypoxic Myoclonus or Acute Symptomatic Seizures." Kyoto University, 2019. http://hdl.handle.net/2433/242412.

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Shoemaker, Danton L. "Examination of Sexual Differences in the Acute Effects of Haloperidol on Licking." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc822780/.

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Schizophrenia is a debilitating psychiatric condition affecting almost one percent of the US population. Typical antipsychotics (e.g., haloperidol) have been in use for several decades and are generally very effective in treating the emotional and cognitive effects of schizophrenia, but are used as the last line of treatment due to their severe extrapyramidal motor side effects under chronic exposure. The present study was conducted to investigate the role of sex in determining the oromotor side effects of typical antipsychotics via measuring different behavioral dimensions of male and female Sprague-Dawley rats licking sucrose after haloperidol treatment. The results showed a stronger sensitivity in female rats than male rats within total licking responses and inter-lick intervals. The present results suggest closer attention needs to be paid to the role that sexual hormones play in the motor slowing and behavior-reducing effects of antipsychotics.

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Danielson, Nathalie, and Johanna Samuelsson. "Anledningar till att föräldrar söker akutsjukvård till sina barn för icke akuta åkommor." Thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-175899.

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SAMMANFATTNING Syfte Syftet med denna studie var att undersöka anledningen till att vissa familjer väljer att söka akutsjukvård till sina barn istället för att vända sig till andra vårdinstanser. Metod En enkät utformades för studien. Enkäten delades ut till familjer som sökte för icke akuta åkommor på en barnakutmottagning i Uppsala län. Studien pågick under en tolvdagarsperiod och avslutades när 80 familjer besvarat enkäten. Frågorna bearbetades med hjälp av beskrivande statistik samt chi2-test. Resultat Den huvudsakliga anledningen till att man valde att söka på barnakutmottagningen var att man telefonledes blivit hänvisad av annan vårdinstans (73,8%). Av de familjer som varit i kontakt med annan vårdinstans hade 70% hänvisats via sjukvårdsrådgivningen/1177.De vanligaste åkommorna som det söktes för var andningsbesvär, luftvägsinfektioner och bukbesvär. Någon skillnad i sökmönster beroende på demografiska faktorer kunde inte urskiljas. Slutsats Studien visade att anledningen till att familjer sökte akutsjukvård för icke akuta åkommor i mycket stor grad berodde på att man hänvisats till barnakutmottagningen av annan vårdinstans. Det är således inte familjernas intention att söka akut i första hand utan systemets utformning som styr familjerna till barnakutmottagningen.
ABSTRACT Aim The aim was to evaluate why families visited the pediatric emergency department with non-acute conditions instead of seeking other healthcare providers. Method A questionnaire was constructed and distributed to families that visited a pediatric emergency department in Uppsala county. The study was terminated after twelve days. 80 families were included. The results were evaluated with descriptive statistics as well as Chi2-test. Results The most common reason (73,8%) for visiting the pediatric emergency department was that the families had been instructed by phone to do so by another health care provider. Of the families that had been referred by another health care provider 70% had been referred by the ”Sjukvårdsrådgiving/1177”. The most common reasons for the visit were troubles with breathing, upper air way infection and abdominal problems. There were no discernable differences in the visiting patterns due to demographic differences. Conclusion The study shows that the reason that families visited the pediatric emergency department for for non-acute conditions to a large degree was that they had been recommended to do so by another health care provider. It is thus not the families own intention to primarily visit the pediatric emergency department but the health care system channels them there.

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Meriläinen, S. (Sanna). "Experimental study of acute pancreatitis in a porcine model, especially tight junction structure and portal vein cytokines." Doctoral thesis, Oulun yliopisto, 2013. http://urn.fi/urn:isbn:9789526200651.

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Abstract Acute pancreatitis is a common disease, Finland being among the countries with the highest incidence. The majority of patients have a mild, self-limiting disease. However, 20% of these patients develop severe necrotizing pancreatitis with a mortality rate of 7 to 25%. The mechanisms for developing the severe disease are not known, it is not possible to accurately forecast the severity of the disease and there is no curative treatment yet. This study was aimed at analyzing the early phase of acute experimental porcine oedematous and necrotizing pancreatitis. In Study I, the pancreatic microcirculatory changes were measured and the expression of tight junction proteins (claudins-2, -3, -4, -5 and -7) and the rate of apoptosis in the pancreas were all measured. In Study II, bacterial translocation to the blood in the portal vein blood or to the mesenteric lymph nodes was analyzed and the intestinal expression of tight junction proteins (claudins-2, -3, -4, -5 and -7) and the intestinal apoptosis/ proliferation rates were measured. The basic histology of the jejunum and colon were analyzed. Study III analyzed which cytokines are released from the pancreas to the portal venous blood. In Study IV, the ultrastructure of the epithelium of the jejunum and colon was analyzed and the expression of adherens junction proteins, E-cadherin and β-catenin, were measured from both jejunum and colon. The first study (I) showed that membranous immunoreactivity of claudin-2 in acinar cells appeared in the pancreas during acute oedematous and necrotizing pancreatitis. The expressions of claudins -3, - 4, - 5 and 7 were unaffected. The second study (II) showed that bacterial translocation from the gut was not present at the beginning of acute porcine pancreatitis. The expressions of claudins-2 and -5 do not become altered; however, there might be some decrease in claudin-3 expression in the colon and decrease in the expression of claudins-4 and -7 in the jejunum in necrotizing pancreatitis. Performing the laparotomy itself caused increased apoptosis in the colon and the jejunum. In the third study (III), the initial inflammatory process was diverse in oedematous and necrotizing pancreatitis. Increased monocyte count in combination with elevated PDGF and IL-6 are characteristic of necrotizing pancreatitis in our model. The fourth study (IV) indicated that necrotizing pancreatitis caused damage to the epithelial and endothelial cells of the colon in the early stages of the disease. The expression of E-cadherin immunoreactivity showed a decreasing trend in the colon in both oedematous and necrotizing pancreatitis. The results of this study suggest that claudin-2 increases in acinar cells during acute porcine pancreatitis. Bacterial translocation is not present during the early phase of acute porcine pancreatitis. Increased monocyte count and elevated PDGF and IL-6 are characteristic of early phase necrotizing porcine pancreatitis and necrotizing porcine pancreatitis causes damage to the epithelial and endothelial cells of the colon
Tiivistelmä Akuutti haimatulehdus on yleinen sairaus, jonka ilmaantuvuus Suomessa on verrattain suuri. Suurimmalla osalla potilaista tauti on lievä ja itsestään paraneva. Kuitenkin 20 %:lle potilaista kehittyy vaikea haimatulehdus, johon liittyy 7–25 %:n kuolleisuus. On epäselvää, miksi toisinaan kehittyy vaikea tautimuoto. Taudin vaikeusastetta ei voida etukäteen tarkasti ennustaa, eikä tautiin ole parantavaa hoitoa. Väitöskirjatyön tarkoituksena oli tutkia lievän ja vaikean haimatulehduksen varhaisvaihetta kokeellisessa sikamallissa. Työssä I mitattiin haiman mikroverenkierron muutoksia, tutkittiin tiivisliitosproteiinien klaudiini-2:n, -3:n, -4:n, -5:n ja -7:n ilmenemistä sekä apoptoosin määrää haimassa. Toisessa työssä tutkittiin mahdollista bakteeritranslokaatiota porttilaskimovereen ja vatsaontelon imusolmukkeisiin, mitattiin suoliston tiivis liitos-proteiinien klaudiinien-2, -3, -4, -5 ja -7 ilmenemistä ja suoliston apoptoosin ja soluproliferaation määrää. Mahdollisia muutoksia ohut- ja paksusuolen perushistologiassa analysoitiin. Kolmannessa työssä mitattiin sytokiinipitoisuuksia porttilaskimoverestä. Neljännessä työssä analysoitiin ohut- ja paksusuolen mikrorakennetta elektronimikroskopian avulla ja mitattiin vyöliitosproteiinien E-cadherin ja β-catenin määrää. I työssä todettiin klaudiini-2:n ilmaantuvan haiman asinaarisolujen solukalvoille lievässä ja vaikeassa kokeellisessa haimatulehduksessa. Klaudiinien 3,- 4,- 5 ja 7 esiintyminen haimassa ei muuttunut. II työssä todettiin, että bakteeritranslokaatiota ei tapahtunut seuranta-aikana. Suolistossa klaudiinien-2 ja -5 ilmenemisessä ei tapahtunut muutoksia. Klaudiini-3:n ilmenemisessä paksusuolessa ja klaudiinien -4 ja -7 ilmenemisessä ohutsuolessa saattaa tapahtua vähenemistä vaikeassa haimatulehduksessa. Tutkimustoimenpide itsessään aiheutti ohut- ja paksusuolen apoptoosin lisääntymistä. III työn mukaan tulehdusvaste oli erilainen akuutissa lievässä ja vaikeassa kokeellisessa haimatulehduksessa. Monosyyttimäärän sekä PDGF:n ja IL-6:n pitoisuuksien lisääntyminen, olivat tyypillisiä vaikealle haimatulehdukselle tässä mallissa. IV työssä todettiin, että vaikea haimatulehdus vaurioittaa paksusuolen epiteeli- ja endoteelisoluja. E-cadherin: n määrässä todettiin jonkin verran vähentymistä sekä lievässä että vaikeassa haimatulehduksessa. Näiden tulosten mukaan klaudiini-2 lisääntyy sian haiman asinaarisoluissa akuutissa haimatulehduksessa. Sialla ei tapahdu bakteerien translokaatiota haimatulehduksen varhaisvaiheessa. Sian vaikeaan haimatulehdukseen liittyy monosyyttien, PDGF:n ja IL-6:n lisääntyminen. Kokeellisessa vaikeassa haimatulehduksessa paksusuolen epiteeli- ja endoteelisolut vaurioituvat jo varhaisvaiheessa

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Silber, Yvonne Beata, and N/A. "The acute side effects of d-amphetamine and methamphetamine on simulated driving performance, cognitive functioning, brain activity, and the standardised field sobriety tests." Swinburne University of Technology, 2006. http://adt.lib.swin.edu.au./public/adt-VSWT20070319.105603.

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Recently there has been an increase in awareness of the role of drugs other than alcohol in the causation of road accidents and deaths, with the most recent report indicating that 33% of all Victorian (Australia) road fatalities are drug (other than alcohol) related (TAC, 2006). Currently in Victoria, one of the classes of drugs reported to be of most concern is the amphetamines. The epidemiological driving literature highlights a possible association between amphetamine use and road crashes. However, since the cognitive research generally indicates cognitive enhancing properties following amphetamine consumption, it remains unclear how amphetamines may be related to adverse driving. The present thesis was designed to explore this issue. In response to the increasing number of drug-related road fatalities, the Standardised Field Sobriety Tests (SFSTs), designed and validated for the detection and assessment of impairment associated with alcohol intoxication, are currently being employed by the Victoria Police (Australia) for the identification of driving impairment associated with drugs other than alcohol. The present thesis was designed to evaluate whether the SFSTs are a sensitive measure for identifying impairment associated with a single acute therapeutic amphetamine dose. Furthermore, the accuracy of using the SFSTs to detect driving impairment associated with these amphetamine doses was also evaluated. The present thesis examined the effects of a single acute therapeutic dose of various amphetamine preparations, on simulated driving performance, driving-related cognitive processes (assessed using standard cognitive tasks and the electroencephalogram [EEG]), and performance on the SFSTs, in healthy, stimulant-using, non-fatigued adults. The present thesis consisted of five separate experiments. The first three experiments examined the effects of d-amphetamine, d,l-methamphetamine, and d-methamphetamine, on simulated driving performance, driving-related cognitive processes, and performance on the SFSTs. Experiment 4 and Experiment 5 assessed the effects of d-amphetamine and dmethamphetamine on visual and auditory cognitive processes using the EEG. These forms of amphetamines were selected as they are commonly used recreationally by young adult drivers, and occupationally by truck drivers. Experiment 1, Experiment 2, and Experiment 3 employed a repeated-measures, counterbalanced, double blind, placebo-controlled design. In each experiment, twenty different (i.e. 60 participants in total) healthy volunteers (10 males and 10 females) completed two treatment conditions i) placebo and ii) 0.42mg/kg amphetamine (~30mg). Driving performance was assessed using a driving simulator task, which consisted of four driving tasks; �freeway traffic driving� and �city traffic driving� in both day and night conditions. Cognitive performance was assessed using a range of computer and pen and paper tasks designed to assess attention, psychomotor performance, and perceptual speed. Specifically, the tasks were: the Digit Span Test; a Digit Vigilance task; a Movement Estimation Task; the Digit Symbol Substitution Test; a Tracking Task; the Trail-Making Test; and the Inspection Time task. SFSTs performance was assessed using the Horizontal Gaze Nystagmus (HGN) test, the Walk and Turn (WAT) test, and the One Leg Stand (OLS) test. Three blood and saliva samples were obtained throughout all experimental sessions (120, 170, and 240 minutes after drug administration). The results indicated that 0.42mg/kg d-amphetamine significantly impaired simulated driving performance, in recreational stimulant users, 2-3 hours post-drug administration, when mean blood amphetamine concentrations were approximately 90ng/mL. No significant driving decrements were observed following d,l-methamphetamine or dmethamphetamine, when methamphetamine blood concentrations were 90ng/mL and 70ng/mL, respectively. There were only few driving behaviours that were found to be significantly reduced with d-amphetamine, such as reductions in signalling adherence and driving too fast for the traffic conditions. However, during all three amphetamine conditions, drivers travelled at a slower speed on the freeway at the time that an emergency situation occurred, relative to the placebo condition. It was argued that either this may result from more cautious driving, or that the reduction in speed acted as a compensatory mechanism to permit drivers to attend to other aspects of driving. Overall, the present results indicate that a therapeutic dose of amphetamine does not produce considerable impairment to driving, as only minimal amphetamine effects were observed on driving performance. In terms of cognitive performance, the results indicated that a therapeutic dose of various amphetamines has minimal effect on driving-related cognitive functioning, with some significant improvements noted in aspects of attention, psychomotor functioning and perceptual speed. This is consistent with the failure to identify significant driving impairments, described above, following a similar dose. However, the ability to perceive and predict motion and estimate �time to contact�, assessed using a movement estimation task, was affected following d-amphetamine and d-methamphetamine consumption. In terms of performance on the SFSTs, the present thesis demonstrated that following the administration of low-level d-amphetamine, d,l-methamphetamine, and dmethamphetamine, performance on the SFSTs was not impaired. Using the SFSTs, impairment associated with low dose d-amphetamine was identified in only 5% of cases, dmethamphetamine in 5% of cases, and d,l-methamphetamine in 0% of cases. These findings indicate that the degree of impairment produced with the low amphetamine dosing conditions was below the threshold of sensitivity of the SFSTs. However, as significant impairments in driving were not observed with amphetamines, the present SFSTs findings highlight that these tests are unlikely to produce false positive results during police drug evaluation procedures for amphetamine-related impairments. Experiment 4 and Experiment 5 similarly employed a repeated-measures, counterbalanced, double blind, placebo-controlled design. In each experiment, twenty healthy volunteers (10 males and 10 females) completed two treatment conditions i) placebo and ii) 0.42mg/kg amphetamine (~30mg). Tasks designed to assess visual and auditory cognitive functions relevant to driving were administered. Specifically, these processes were: divergent visual system pathways (magnocellular and parvocellular pathways); aspects of visual field processing (central and peripheral visual fields); mismatch negativity (MMN); prepulse inhibition (PPI); selective attention; resource allocation; and speed of processing. Two blood and saliva samples were obtained throughout all experimental session (120 and 200 minutes after drug administration). d-amphetamine and d-methamphetamine generally improved cognitive functioning, as assessed with visual and auditory ERP indices. Specifically, the results demonstrated that a low-level acute dose of d-amphetamine and d-methamphetamine improved early processing of visual information (indexed by improvements to the P100 component for the magnocellular and parvocellular visual pathways). In addition, d-methamphetamine improved the speed at which visual information was evaluated and processed (indexed by decreases in P300 latency), which was consistent with d-methamphetamine-related improvements in reaction time. There was a trend for d-amphetamine to improve the speed that changes in auditory stimulation were automatically detected (indexed by decreases in MMN latency). In addition, d-methamphetamine improved the ability to automatically �screen out� irrelevant and intrusive auditory information (indexed by increases in PPI of the startle response). d-amphetamine was found to improve the speed at which auditory information was evaluated and processed (indexed by decreases in P300 latency), which was substantiated with corresponding improvements in reaction time and accuracy. Although amphetamines were generally shown to enhance ERP indices, a trend was found for d-amphetamine to differentially affect different regions of the visual field, in terms of selective attention. Specifically, there was a trend-level indication that d-amphetamine improved indices of selective attention (denoted by increases in N200 amplitude) for information presented centrally, but impaired indices of selective attention (denoted by decreases in N200 amplitude) for information presented in the periphery. Although impairments to the peripheral visual field were not similarly observed with dmethamphetamine, decrements to indices of selective attention (denoted by decreases in N200 amplitude) were also found with d-methamphetamine during the auditory oddball task. In terms of driving, these results suggest that drivers dosed with low-level amphetamine may not selectively attend to and discriminate changes within the traffic environment, although further research is required to confirm this. In conclusion, the present thesis has demonstrated that a single acute therapeutic dose of amphetamine produces minimal and inconsistent effects to driving. However, some (inconsistent) evidence was found that suggests that there may be mild impairments such as decreased ability to perceive and predict motion, tunnel vision effects, and decrements to selective attention. In addition, the present thesis highlights that at therapeutic doses, amphetamines do not impair SFSTs performance, which is in accordance with the failure to identify substantive amphetamine-related decrements to driving and cognitive functioning observed in the present thesis.

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Silber, Yvonne Beata. "The acute side effects of d-amphetamine and methamphetamine on simulated driving performance, cognitive functioning, brain activity, and the standardised field sobriety tests." Australasian Digital Theses Program, 2006. http://adt.lib.swin.edu.au/public/adt-VSWT20070319.105603/index.html.

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Thesis (PhD) - Swinburne University of Technology, 2006.
Typescript. [Submitted for the degree of] Doctor of Philosophy, Swinburne University of Technology - 2006. Includes bibliographical references (p. 253-290).

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Keele, Jacque Anne. "Regulation of arginine metabolism following acute myocardial infarction in mice." Laramie, Wyo. : University of Wyoming, 2008. http://proquest.umi.com/pqdweb?did=1707917171&sid=1&Fmt=2&clientId=18949&RQT=309&VName=PQD.

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Books on the topic "Sida acuta"

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Sourati, Ainaz, Ahmad Ameri, and Mona Malekzadeh. Acute Side Effects of Radiation Therapy. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-55950-6.

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Hinkelbein, Wolfgang, Gregor Bruggmoser, Hermann Frommhold, and Michael Wannenmacher, eds. Acute and Long-Term Side-Effects of Radiotherapy. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-84892-6.

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Bruneau, William. A User's Guide to Sida acuta, Sida cordifolia, and Sida rhombifolia : : How to Grow, Harvest, and Make Medicinals from the World's Best Herbal ... Superior Fiber, Grow Them with Your Tomatoes. CreateSpace Independent Publishing Platform, 2018.

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Wagg, Adrian, and Shashi Gadgil. Acute pain in the elderly. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199234721.003.0011.

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Physiological changes that occur with age affect the pharmacokinetics and pharmacodynamics of drugs used in acute pain management. Elderly patients are often reluctant to complain of pain and seek treatment and may sometimes be unable to express pain due to impaired cognition or language. Evidence suggests the elderly as a group that receive inadequate analgesia and are often in pain. Health care professionals are often reluctant to administer sufficient analgesia due to fear of encouraging addiction or inducing side effects. The approach to pain management in this group should follow the World Health Organization (WHO) analgesic ladder with close monitoring for potential side effects and with escalation of treatment till sufficient analgesia is achieved. Choice of drugs and the route of administration should be tailored to the individual patient and should consider the nature of their pain and any disability or co-morbidity that will affect their response to the chosen agent. Non-steroidal anti-inflammatory drugs (NSAIDs) should be used with extreme caution, monitoring for potential gastrointestinal (GI) and renal side effects and long-term use should be avoided if possible. Opioids are effective analgesics and should not be denied to the elderly but their use should be monitored carefully and side effects such as nausea and constipation anticipated and treated.

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Cassidy, Jim, Donald Bissett, Roy A. J. Spence OBE, Miranda Payne, and Gareth Morris-Stiff. Overview of acute oncology. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199689842.003.0031.

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Describes the common causes of spinal cord compression, the symptoms and speed of onset. Outlines immediate diagnostic and therapy options. Emphasis on the need for early diagnosis and therapy to ensure optimal outcomes in longer term.Describes the most common and dreaded of cytotoxic chemotherapy side-effects which is pancytopaenia caused by killing of bone marrow cells. Life threatening when accompanied by infection – neutropaenic sepsis. Outlines symptoms, investigations and immediate therapy guidelines.

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Sourati, Ainaz, Ahmad Ameri, and Mona Malekzadeh. Acute Side Effects of Radiation Therapy: A Guide to Management. Springer, 2018.

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Sourati, Ainaz, Ahmad Ameri, and Mona Malekzadeh. Acute Side Effects of Radiation Therapy: A Guide to Management. Springer, 2017.

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Walker, Suellen M. Evidence and outcomes in acute pain management. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199234721.003.0005.

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Inadequate control of post-operative pain can be associated with acute morbidity and have adverse effects on recovery and emotional well-being. The aims of acute pain medicine are reducing pain intensity, control of side effects, hastening rehabilitation, and improving acute and long-term outcomes. League tables compare the efficacy of analgesics, based on the number-needed-to-treat (NNT) to achieve 50% pain reduction. Systematic reviews of different interventions for acute pain are conducted and regularly updated in the Cochrane Library. The second edition of Acute Pain Management: Scientific Evidence by the Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine provides a useful summary of the current evidence.

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1948-, Hinkelbein W., ed. Acute and long-term side-effects of radiotherapy: Biological basis and clinical relevance. Berlin: Springer-Verlag, 1993.

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Wannenmacher, Michael, Wolfgang Hinkelbein, Gregor Bruggmoser, and Hermann Frommhold. Acute and Long-Term Side-Effects of Radiotherapy: Biological Basis and Clinical Relevance. Springer, 2011.

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Book chapters on the topic "Sida acuta"

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Azimova, Shakhnoza S., and Anna I. Glushenkova. "Sida acuta Burm." In Lipids, Lipophilic Components and Essential Oils from Plant Sources, 633–34. London: Springer London, 2012. http://dx.doi.org/10.1007/978-0-85729-323-7_2062.

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Khare, C. P. "Sida acuta Burm. f." In Indian Medicinal Plants, 1. New York, NY: Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-70638-2_1493.

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Sourati, Ainaz, Ahmad Ameri, and Mona Malekzadeh. "Hematological Side Effects." In Acute Side Effects of Radiation Therapy, 191–206. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-55950-6_19.

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Silies, H., J. Boos, G. Blaschke, and H. Jürgens. "Infusion Rate Does Not Influence Ifosfamide Side-Chain Metabolism." In Acute Leukemias VI, 526–32. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60377-8_83.

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Chung, Jong H., Anurag K. Agrawal, and Patrick S. Swift. "Management of Acute Radiation Side Effects." In Supportive Care in Pediatric Oncology, 203–21. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-44317-0_13.

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Annamalai, Aniyizhai. "Hypertension and Acute Hypertensive Crisis." In Medical Management of Psychotropic Side Effects, 31–38. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-51026-2_4.

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Annamalai, Aniyizhai. "Diabetes Mellitus and Acute Hyperglycemia." In Medical Management of Psychotropic Side Effects, 23–30. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-51026-2_3.

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Sourati, Ainaz, Ahmad Ameri, and Mona Malekzadeh. "Radiation Dermatitis." In Acute Side Effects of Radiation Therapy, 1–19. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-55950-6_1.

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Sourati, Ainaz, Ahmad Ameri, and Mona Malekzadeh. "Radiation Pneumonitis." In Acute Side Effects of Radiation Therapy, 109–15. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-55950-6_10.

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Sourati, Ainaz, Ahmad Ameri, and Mona Malekzadeh. "Pericarditis." In Acute Side Effects of Radiation Therapy, 117–23. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-55950-6_11.

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Conference papers on the topic "Sida acuta"

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"IMRT in carcinoma cervix: Maximizing the gain and nipping the side effects: RGCI experience." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685268.

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Objective: To present a single institutional experience with acute toxicity, patterns of failure and survival in carcinoma cervix treated using definitive radiotherapy with IMRT technique. Methods: It is a retrospective analysis of 64 patients with carcinoma cervix treated with definitive chemoradiation (IMRT) from April 2011 to Jan 2013. Patients with squamous or adenocarcinoma histology and no metastasis, treated with definitive radiotherapy (IMRT) with or without concurrent chemotherapy were included. Acute toxicities were presented as proportions and kaplainmeier computation was done to calculate 3 years disease free survival (DFS) and 3 years overall survival (OS). Results: Median follow up was months for the entire cohort. Mean age was 55.9 years (SD 9.93). Majority of patients (92.8%) had locally advanced disease (FIGO II and III) and squamous cell carcinoma (96.9%). Mean dose to pelvis with IMRT was 49.75 Gy (SD 1.78) followed by ICRT, EBRT boost and implant in 79.7%, 17.2% and 3.1% respectively (as indicated). Response evaluation done at 3 months of treatment completion showed 83.6% complete response, 11.5% partial response and 4.9% progressive disease. During follow up 21.6% developed recurrence - 44.4% failed locally, 16.7% at para-aortic nodal region and 38.9% at distant sites. The 3 year DFS and OS was 70.8% and 60.3% respectively. Patients had tolerable acute toxicities. Incidences of grade ≥3 acute toxicity were 3.1% for anemia, 10.9% for neutropenia, 25% for thrombocytopenia, 1.5% for nausea, 0% for vomiting, 12% for GU and 12% for GI toxicities. Incidence of grade I, II and III radiation dermatitis were 38.89%, 27.78% and 22.2% respectively. None developed grade IV radiation dermatitis. Conclusion: IMRT for carcinoma cervix seems to provide improved outcomes and toxicity profile, although it should be compared with conventional radiotherapy in a well randomized control setting so as to have true and meaningful comparison.

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Momier, P., U. Sigwart, F. Bachmnn, C. Ferret, and L. Kapperiberger. "SYSTEMIC THRCMBOLYSIS WITHIN THE FIRST 3 HOURS OF ACUTE CORONARY THROMBOSIS : APSAC VS STREPTOKINASE : A RAMDCMIZED STUDY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642995.

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Intravenous administration of thrombolytic agents in acute myocardial infarction may be preferable to intracoronary thrombolysis for practiced, reasons and to reduce time to reperfusion. As compared to the streptokinase infusion, the bolus injection of APSAC may be even more rational. We have therefore compared the effects of one intravenous bolus injection of APSAC (30 units in 5 min) to an intravenous injection of streptokinase (1.500.000 units in 60 min) within the first 3 hours (mean 141 min for APSAC and 135 min for streptokinase) after the onset of symptoms associated with acute myocardial infarction. All patients received i.v. heparin at therapeutic dosage for 24 hours starting 3-4 hours after the onset of therapy.14 patients were randomized to the APSAC group and 11 to the streptokinase group. Coronary angiography carried dout 2.5 hours after beginning of treatment revealed a patency rate (complete opacification of the vessel at selective injection) of 92% (13 of 14 patients) for APSAC and 63% (7 of 11 patients) for streptokinase. Both thrombolytic agents produced similar fall in plasma fibrinogen levels. One death occurred in the streptokinase on day 4 due to rupture of the anterior ventricular wall. No other side effects were life-threatening, there consisted of local bleeding at the punction side. We conclude that APSAC is at least as efficient as streptokinase and easier to administer in patients with acute myocardial infarction.

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Bleyl, H. "TWO-SIDE IMMUNOASSAYS OF ENZYME-INHIBITOR COMPLEXES FOR THE DIAGNOSIS OF THROMBOPHILIC STATES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643113.

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The diagnosis of prethrombotic states requires methods which detect products of intravasal activation of the coagulation cascade.Two-side immunoassays for antithrombin complexes with clotting factors were developed (IXi-AT, Xi-AT, IIi- AT). These sandwich assays permit the diagnosis of hypercoagulability in the presence or absence of heparin. The biological half live time of the thrombin-antithrombin-complex was found to be about 15 min. Healthy young men 20-25 years old (n=30) have a thrombin-antithrombin-complex concentration of 0.4 ± 0.2 mU/ml thrombin equivalent (S 2238). Patients with acute myocardial infarction (n=40) showed at the time of admission to the hospital up to 10-fold (n=14), up to 100-fold (n=13) more than 100-fold (n=13) elevated thrombin-antithrombin-complex concentrations. Patients with gastrointestinal cancer showed sometime excessive elevated enzyme-inhibitor complexes.No correlation was found between thromboplastine time (Quick) and complex concentration in patients under anticoagulant therapy with dicumarole. In patients under dialysis as well as in patients under open heart surgery with extracorporal circulation, the biocompatibility can be monitored by inhibitor complex measurement.

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Drieu la Rochelle, Armand, Karel Guillemyn, Maria Dumitrascuta, Simon Gonzalez, Charlotte Martin, Valérie Utard, Raphaëlle Quillet, et al. "A Bifunctional Biased Mu Opioid Agonist - Neuropeptide Ff Receptor Antagonist as Analgesic with Improved Acute and Chronic Side Effects." In 35th European Peptide Symposium. Prompt Scientific Publishing, 2018. http://dx.doi.org/10.17952/35eps.2018.276.

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Hirschberg, M., A. Manoutchei, B. Klemens, and B. Hofferberth. "CEREBRAL THROMBOLYSIS WITH INTRAVENOUSLY ADMINISTERED RECOMBINANT LOW- MOLECULAR-WEIGHT-UROKINASE AND RECOMBINANT PRO-UROKINASE IN A DOG MODEL." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643571.

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There is increasing evidence that recombinant prourokinase (rec-pro-UK) is a proenzyme which in vivo systems may induce activation of the fibrinolytic system with a better thrombus selectivity than that obtained with active urokinase.In order to study the effects of rec-pro-UK and low-molecular-weight-urokinase (LMW-UK) on acute stroke, a thrombus was induced in the middle cerebral artery (MCA) of anesthetized mongrel dogs (n=12). Occlusion of the vessel was confirmed by angiography. Following a 1 hour period of MCA occlusion, in six animals LMW-UK was administered intravenously at a dose of 4000 lU/kg/min. Angiographically confirmed thrombolysis occurred after 30 minutes. Thrombolysis by LMW-UK was accompanied by bleeding from all surgical wounds and consumption of plasminogen, alpha-2-antiplasmin and fibrinogen. Rec-pro-UK was administered to six other dogs in a LMW-UK-equivalent dosis. Thrombolysis was achieved after 30 minutes in all six cases without inducing a systemic lytic state. Neither in the LMW-UK-group nor in the group treated with rec-pro-UK intracerebral bleeding complications were observed on post mortem examination.Our findings indicate that intravenous administration of rec-pro-UK - because of the lack of systemic side-effects - may be a safe way of rapid thrombolysis of occluded cerebral arteries in acute stroke.

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Miller, Jonathon D., Gennine R. Kärrsten, and Curt E. Haveman. "Best Practices for Minimizing Mooring Failures at the Fairlead." In ASME 2014 33rd International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/omae2014-24336.

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Although preventive maintenance is not a new concept when dealing with mooring systems, experience shows that the implementation is not always successful. As important as new technologies are in improving mooring integrity, it is equally important to ensure that well-established best practices remain in place. As the industry approaches a period where extending service life of floating structures is desirable, but the existing mooring system has reached the twilight of its service life, the need for properly maintaining the mooring system is more acute. With time on their side, the prudent operator can implement small regular steps to extend mooring system service life. This paper presents methodologies to maximize design life by highlighting design and operational best practices, maintenance and monitoring, and identifying common reasons why these best practices are not implemented.

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Tunçdemir, Matem. "Apoptosis related genes and protein expression, depending on the radiation therapy role of the developing acute side effect in breast cancer patients." In 15th International Congress of Histochemistry and Cytochemistry. Istanbul: LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.pp-37.

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Wang, Zhongqi, and Wanjin Han. "The Chordwise Lean of Highly Loaded Turbine Blades." In ASME 1996 International Gas Turbine and Aeroengine Congress and Exhibition. American Society of Mechanical Engineers, 1996. http://dx.doi.org/10.1115/96-gt-074.

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An experimental investigation was carried out on the effect of blade chordwise lean on the losses in highly loaded rectangular turbine cascades. Detail measurements include 10 traverses from the upstream to the downstream of the cascades with five-hole spherical probes. Compared with the experimental data of the conventional straight and pitchwise lean blades under the same conditions, it is shown that the effect of chordwise lean on the development of the cascade losses is similar to that of pitchwise lean. However, the chordwise lean produces smaller streamwise adverse pressure gradients near both endwalls and a smaller spanwise negative one starting from the acute angle side in the first part of the passages in chordwise lean cascade, thereby the saddle point separations and intensities of the passage vortices are weakened and the secondary vortex losses are cut down notably.

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Diefenbach, C., R. Erbel, J. Meyer, C. W. Hamm, J. Schofer, and D. G. Mathey. "DOSE-FINDING STUDY OF THROMBOLYSIS IN ACUTE MYOCARDIAL INFARCTION BY SINGLE-CHAIN PROUROKINASE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643569.

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In 24 patients (pts)(mean age 54.2 ± 12.1 years) with acute myocardial infarction (onset of symptoms <6 hrs; mean duration 181.8±54.4 minutes) single-chain prourokinase (PUK) was applied intravenously. PUK is an inactive proenzyme of human urokinase isolated from recombinant Escherichia coli. Efficiency and safety of low and high dose application were analysed. Complete coronary artery occlusion was proved before start of thrombolysis therapy. After 5000 IU heparine intravenously the first 12 pts were given 10 mg as a bolus followed by 30 mg within 1 hour (group A), the next 12 pts received the double dose: 20 mg as a bolus and 60 mg within 1 hour (group B). After PUK infusion 20 IU/ kg heparine were administered continously in all pts for 72 hours. There were no significant differences in age, bodyweight and duration of symptoms in both groups In group A in 6 of 12 pts (50%) reperfusion of the occluded coronary artery was achieved within 58.3±17.2 minutes; in group B 9 of 12 (75%) vessels reopened within 44.0±29.9 minutes. The remaining stenosis of coronary artery was 91% in both groups. In group A no drop of fibrinogen or plasminogen was observed; only 2 pts of group B showed significant drops of fibrinogen (below 100 mg%) and plasminogen (below 40%) plasma level. In no patient major bleeding or any other acute adverse effect occurred.Thus, intravenous application of 80 mg PUK is more effective than 40 mg PUK with low incidence of systemic side effects.

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Tubaldi, Eleonora, Giovanni Ferrari, Prabakaran Balasubramanian, and Marco Amabili. "Dynamic Behaviour of a Dacron Aortic Graft." In ASME 2019 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/imece2019-11520.

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Abstract Woven Dacron grafts are still considered the clinical standard practice in thoracic vascular reconstruction in the case of aortic aneurysm and acute dissection. Despite its characteristics of biocompatibility and durability, very little is known about the dynamic response of Dacron grafts and about their side effects on the heart workload and cardiovascular system. In this study, physiological blood flow conditions are imposed in a Dacron graft via a specifically-developed mock circulatory loop. The effects of different physiological pulsation-per-minute rates are investigated. Since the Dacron prosthesis is extremely stiffer circumferentially and compliant axially with respect to an aortic segment of the same length, bending oscillations are preferred by the graft. This leads to a very significant different dynamic behavior with respect to the replaced human aortic portion altering cardiovascular pressure and blood flow dynamics and eventually causing long-term implant complications.

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Reports on the topic "Sida acuta"

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Lumpkin, Shamsie, Isaac Parrish, Austin Terrell, and Dwayne Accardo. Pain Control: Opioid vs. Nonopioid Analgesia During the Immediate Postoperative Period. University of Tennessee Health Science Center, July 2021. http://dx.doi.org/10.21007/con.dnp.2021.0008.

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Background Opioid analgesia has become the mainstay for acute pain management in the postoperative setting. However, the use of opioid medications comes with significant risks and side effects. Due to increasing numbers of prescriptions to those with chronic pain, opioid medications have become more expensive while becoming less effective due to the buildup of patient tolerance. The idea of opioid-free analgesic techniques has rarely been breached in many hospitals. Emerging research has shown that opioid-sparing approaches have resulted in lower reported pain scores across the board, as well as significant cost reductions to hospitals and insurance agencies. In addition to providing adequate pain relief, the predicted cost burden of an opioid-free or opioid-sparing approach is significantly less than traditional methods. Methods The following groups were considered in our inclusion criteria: those who speak the English language, all races and ethnicities, male or female, home medications, those who are at least 18 years of age and able to provide written informed consent, those undergoing inpatient or same-day surgical procedures. In addition, our scoping review includes the following exclusion criteria: those who are non-English speaking, those who are less than 18 years of age, those who are not undergoing surgical procedures while admitted, those who are unable to provide numeric pain score due to clinical status, those who are unable to provide written informed consent, and those who decline participation in the study. Data was extracted by one reviewer and verified by the remaining two group members. Extraction was divided as equally as possible among the 11 listed references. Discrepancies in data extraction were discussed between the article reviewer, project editor, and group leader. Results We identified nine primary sources addressing the use of ketamine as an alternative to opioid analgesia and post-operative pain control. Our findings indicate a positive correlation between perioperative ketamine administration and postoperative pain control. While this information provides insight on opioid-free analgesia, it also revealed the limited amount of research conducted in this area of practice. The strategies for several of the clinical trials limited ketamine administration to a small niche of patients. The included studies provided evidence for lower pain scores, reductions in opioid consumption, and better patient outcomes. Implications for Nursing Practice Based on the results of the studies’ randomized controlled trials and meta-analyses, the effects of ketamine are shown as an adequate analgesic alternative to opioids postoperatively. The cited resources showed that ketamine can be used as a sole agent, or combined effectively with reduced doses of opioids for multimodal therapy. There were noted limitations in some of the research articles. Not all of the cited studies were able to include definitive evidence of proper blinding techniques or randomization methods. Small sample sizes and the inclusion of specific patient populations identified within several of the studies can skew data in one direction or another; therefore, significant clinical results cannot be generalized to patient populations across the board.

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Evidence Update for Clinicians: Narrow- versus Broad-Spectrum Antibiotics for Common Infections in Children. Patient-Centered Outcomes Research Institute (PCORI), October 2018. http://dx.doi.org/10.25302/eu5.2018.10.

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Comparing Narrow- vs. Broad-Spectrum Antibiotics for Common Infections in Children. The choice of antibiotic to treat acute bacterial upper respiratory tract infections in children can affect both symptom resolution and the risk of side effects such as diarrhea and vomiting. The findings of a PCORI-funded study published in JAMA can help clinicians treating children for acute respiratory tract infections (ARTIs)—including acute otitis media, Group A streptococcal pharyngitis, and acute sinusitis—make decisions with parents about the medicine that is best for the child. The study, led by Jeffrey Gerber, a pediatrician and researcher at the Children’s Hospital of Philadelphia, included 30,086 children ages 6 months to 12 years taking narrow- and broad-spectrum antibiotics to treat ARTIs.

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