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1

Urmi, Amina Begum, Arjina Akter Ankhi, Md Aminul Islam, et al. "Comprehensive Evaluation of the Antihyperlipidemic Effects of Sida cordifolia in Rodent Models." Journal of Complementary and Alternative Medical Research 26, no. 5 (2025): 102–8. https://doi.org/10.9734/jocamr/2025/v26i5659.

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Hyperlipidemia is a major risk factor for cardiovascular diseases and metabolic disorders, necessitating the development of safe and effective therapeutic agents. Sida cordifolia, a medicinal plant traditionally used in Ayurvedic medicine, has shown potential lipid-lowering properties. This study aimed to comprehensively evaluate the antihyperlipidemic effects of Sida cordifolia extracts in rodent models. Wistar albino rats were divided into normal control, hyperlipidemic control, standard (atorvastatin-treated), and test groups treated with ethanolic and aqueous extracts of Sida cordifolia at varying doses. Hyperlipidemia was induced using a high-fat diet. Serum lipid profiles—including total cholesterol, triglycerides, LDL-C, and HDL-C—were measured at baseline and post-treatment. Histopathological analysis of liver tissues was also performed to assess hepatic integrity. Results indicated a significant reduction in total cholesterol, triglycerides, and LDL-C, with a concurrent increase in HDL-C levels in Sida cordifolia-treated groups, particularly at higher doses. Histological findings supported biochemical results, showing reduced lipid accumulation and improved hepatic architecture. These findings suggest that Sida cordifolia possesses potent antihyperlipidemic activity, supporting its potential use as a natural therapeutic agent for managing dyslipidemia. These findings position Sida cordifolia as a promising natural candidate for the management of hyperlipidemia, warranting further clinical validation and standardization for therapeutic use.
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2

Sharma, Bhupendra, Rishi Dewangan, and Shyam Sharma. "Characterizing the mechanical behavior of eco-friendly hybrid polymer composites with jute and Sida cordifolia fibers." Metal Working and Material Science 26, no. 3 (2024): 267–85. http://dx.doi.org/10.17212/1994-6309-2024-26.3-267-285.

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Introduction. Recognition of the medicinal properties of plants is an integral part of traditional Indian health systems such as Unani, Siddha, Naturopathy and Ayurveda. Among others, Sida cordifolia, a member of the Malvaceae family, is especially celebrated in Ayurvedic medicine for its outstanding chemical properties. This plant grows in the subtropical and tropical climate of India and symbolizes the global shift towards more environmentally friendly materials. Given the rising environmental concerns, there is an increased demand for biodegradable and renewable resources for industrial applications, especially for reinforcing polymer matrices with natural fibers. The purpose of this study is to investigate the effectiveness of Sida cordifolia fibers combined with jute for reinforcing polylactic acid (PLA) composites. This highlights its potential to improve both environmental quality and mechanical properties of materials. Materials and method. The study involved the fabrication of four different composite specimens: : a solely 4-layered jute fiber mat, untreated Sida cordifolia fibers combined with a 4-layered jute mat, and Sida cordifolia fibers treated with benzoylation combined with a 4-layered jute mat. These composites were subjected to mechanical testing focusing on tensile strength and flexural strength. Its microstructural analysis was also carried out. Results and discussion. The results show that benzoylation-treated Sida cordifolia fibers exhibit significantly higher strength compared to its untreated counterparts. At the same time, an increase in the proportion of Sida cordifolia fibers in composites while maintaining a constant total mass correlates with an increase in the strength of the materials. These results indicate that Sida cordifolia and jute fiber-reinforced PLA composites can provide a competitive, environmentally friendly alternative to synthetic fiber-reinforced composites in a variety of industrial applications. In conclusion, treated natural fibers like Sida cordifolia can significantly improve the mechanical properties of polymer composites, supporting its use as environmentally friendly, high-performance materials in a variety of industries. This research not only promotes the use of natural fibers for commercial applications, but also contributes to the larger goal of sustainable materials science.
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3

Sutradhar, Ranajit K., A. K. M. Matior Rahman, Mesbah U. Ahmad, and Sitesh C. Bachar. "Bioactive flavones of Sida cordifolia." Phytochemistry Letters 1, no. 4 (2008): 179–82. http://dx.doi.org/10.1016/j.phytol.2008.09.004.

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4

Nishigandha, Yadav* Poorva Bhailume Tanaya Birdawade Vaishnavi Divekar Hrishita Shetty Angad Yelwe. "Zingiber Officinale and Sida Cordifolia as Nature's Defenders: Exploring their Action Against Inflammation and Parasite." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 1979–85. https://doi.org/10.5281/zenodo.15228778.

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Inflammation and parasitic infections pose significant health challenges, requiring effective and sustainable treatment approaches. This study investigates the anti-inflammatory and anthelmintic properties of Zingiber officinale (ginger) and Sida cordifolia, two medicinal plants traditionally used for their therapeutic effects. Using an egg albumin denaturation assay, the anti-inflammatory potential of these plant extracts was assessed, demonstrating a dose-dependent inhibition of protein denaturation. Notably, the combined extract of Sida cordifolia and ginger exhibited a synergistic effect, approaching the efficacy of Diclofenac sodium. Likewise, anthelmintic activity was evaluated using Pheretima posthuma (earthworms) as a biological model. Results revealed that ginger induced faster paralysis and death of the worms compared to Sida cordifolia alone, while their combination displayed enhanced potency, comparable to the standard drug Albendazole. These findings highlight the therapeutic prospects of Sida cordifolia and ginger as natural alternatives for managing inflammation and parasitic infections, supporting their traditional use and encouraging further pharmacological exploration.
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5

Arshad, S., I. Hussain, M. Ibrahim, et al. "Biochemical studies on protein, phenolic contents and antioxidant activities of Sida cordifolia extracts." Bulletin of the Chemical Society of Ethiopia 34, no. 2 (2020): 427–34. http://dx.doi.org/10.4314/bcse.v34i2.18.

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The study aimed to characterize the antioxidant properties regarding the Sida cordifolia with special reference to its detailed biochemical analysis. The study revealed that chlorophyll A (0.9 ± 0.3 mg/g), total chlorophyll content (3.0 ± 0.7 mg/g), total carotenoid content (0.3 ± 0.1 mg/g), total soluble proteins (7.5 ± 0.1 mg/g), and total phenolic contents (5.6 ± 1.3 mg/g) were found highest in flower tissue of S. cordifolia. However, peroxidase (POD) contents (118 ± 31 units/g), superoxide dismutase (SOD) activity (64 ± 1.5 units/g) were maximum in the leaf tissues, while catalase (CAT) contents (133 ± 25 units/g), ascorbate peroxidase (APX) contents (145 ± 44 units/g) were also found more in the flowers of S. cordifolia rather than other parts. Our results conclude that leaves, stem, flower of S. cordifolia could be exploited in pharmacology due to presence of different antioxidants reflected in flower and leaf extract make them potent and profound therapeutic agents.
 
 KEY WORDS: Alkaloids, Flavonoids, Phenolics, Antioxidant, Sida cordifolia
 
 Bull. Chem. Soc. Ethiop. 2020, 34(2), 427-434
 DOI: https://dx.doi.org/10.4314/bcse.v34i2.18
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6

Bianco, S., L. B. Carvalho, and M. S. Bianco. "Estimativa da área foliar de Sida cordifolia e Sida rhombifolia usando dimensões lineares do limbo foliar." Planta Daninha 26, no. 4 (2008): 807–13. http://dx.doi.org/10.1590/s0100-83582008000400012.

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A estimativa da área foliar pode auxiliar na compreensão de relações de interferência entre plantas daninhas e cultivadas. Com o objetivo de obter uma equação que, por meio de parâmetros lineares dimensionais das folhas, permita a estimativa da área foliar de Sida cordifolia e Sida rhombifolia, estudaram-se as correlações entre área foliar real (Af) e parâmetros dimensionais do limbo foliar, como o comprimento (C) ao longo da nervura principal e a largura máxima (L) perpendicular à nervura principal. Foram analisados 200 limbos foliares de cada espécie, coletados em diferentes agroecossistemas na Universidade Estadual Paulista, campus de Jaboticabal. Os modelos estatísticos utilizados foram linear: Y = a + bx; linear simples: Y = bx; geométrico: Y = ax b; e exponencial: Y = ab x. Todos os modelos analisados podem ser empregados para estimação da área foliar de S. cordifolia e S. rhombifolia. Sugere-se optar pela equação linear simples, envolvendo o produto C*L, considerando-se o coeficiente linear igual a zero, em função da praticidade desta. Desse modo, a estimativa da área foliar de S. cordifolia pode ser obtida pela fórmula Af = 0,7878*(C*L), com coeficiente de determinação de 0,9307, enquanto para S. rhombifolia a estimativa da área foliar pode ser obtida pela fórmula Af = 0,6423*(C*L), com coeficiente de determinação de 0,9711.
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7

BARACHO, GEORGE SIDNEY, and MARIA DE FÁTIMA AGRA. "New synonyms and lectotypifications in Sida (Malvaceae-Malveae) reveal the first record and extension of the distribution area of Sida maculata to Brazil." Phytotaxa 660, no. 3 (2024): 287–93. http://dx.doi.org/10.11646/phytotaxa.660.3.6.

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New synonyms and lectotypes in Sida sect. Cordifoliae (Malvaceae, Malveae) are proposed here and reveal the first record and extension of the distribution area of Sida maculata to the Brazilian semi-arid region. The species was first described in the 18th century for the Caribbean islands of Cuba and the Dominican Republic and for a long time was confused with S. cordifolia, from which it is unquestionably distinct in its leaves, inflorescences and flowers. In Brazil, S. maculata is widely distributed from Maranhão to the north of Minas Gerais and was identified for almost a century in herbaria and local floristic treatments as S. galheirensis. Discussions and photographs of types of S. maculata and related taxa are presented, as well as an updated map of the species’ geographical distribution.
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8

Uko, Ogwo Elisha, Obioma Elizabeth Nweke, Okoye Ogochukwu Fidelis, Ubani Clement Dimgba, and Suleiman Ali Sani. "Biochemical and Haematological Effects of Aqueous Leaf Extract of Sida cordifolia in Plasmodium beighei Infected Wistar Rats." International Journal of Pathogen Research 13, no. 3 (2024): 1–5. http://dx.doi.org/10.9734/ijpr/2024/v13i3280.

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Assessment of haematological and biochemical parameters can be predictive of the adverse effects resulting from ingesting foreign substances. Thus, the aim of this study was to evaluate the biochemical and haematological indices in Plasmodium beighei infected wistar rats. Freshly harvested leaves of Sida cordifolia were washed and dried at room temperature, after which they were ground to fine powder and subsequently extracted. Twenty-five adult Wistar rats were divided into five groups of five rats each. Group I was the normal control and was administered 2 ml of distilled of water. Group II was infected without treatment, while Group III and IV were infected and afterwards administered 200 and 400 mg/kg of aqueous extract of Sida cordifolia respectively. Group V was administered the standard drug. Biochemical and haematological indices were determined using standard procedures. The Packed Cell Volume (PCV) reported for group II (negative) control was significantly (P<0.05) lower than that reported for the normal control. However, oral administration of 200 and 400 mg/kg of Sida cordifolia leaf extract significantly (P<0.05) increased it, though to a level which was significantly (P<0.05) lower than that reported for the normal control. Similar observation was made on Haemoglobin Concentration (Hb) and Red Blood Cell (RBC). However, a contrary observation was made on the white blood cell. Urea and creatinine reported for the negative control were significantly (P<0.05) higher than those reported for the normal control. However, the aforementioned parameters were significantly (P<0.05) reduced following oral administration of Sida cordifolia. In conclusion, it can be deduced from this study that Sida cordifolia leaf extract has the ability to restore distorted haematological and biochemical status resulting from P. berghei infection.
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9

Silva, Renata Lemos, Gustavo Barreto de Melo, Valdinaldo Aragão de Melo, et al. "Effect of the aqueous extract of Sida cordifolia on liver regeneration after partial hepatectomy." Acta Cirurgica Brasileira 21, suppl 1 (2006): 37–39. http://dx.doi.org/10.1590/s0102-86502006000700009.

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PURPOSE: The use of medicinal plants for the treatment of human diseases has increased worldwide. Many of them are used by oral administration and, after absorption, may affect many organs. Therefore, this study aimed at assessing the effects of the aqueous extract of Sida cordifolia leaves, popularly known in Brazil as "malva-branca", on liver regeneration. METHODS: Twenty rats were divided into four groups: control, Sida100, Sida200 and Sida400 groups. All animals were submitted to oral administration of distilled water, 100, 200 and 400 mg/kg of the aqueous extract of Sida cordifolia, respectively. Immediately after this, they underwent 67% partial hepatectomy. Twenty four hours later, their livers were removed. Hepatic regeneration was assessed by immunohistochemical staining for proliferating cell nuclear antigen (PCNA) using the PC-10 monoclonal antibody. RESULTS: Sida100 and Sida200 groups disclosed higher liver regeneration indices than control group (p<0.001 and p<0.05, respectively). CONCLUSION: The aqueous extract of Sida cordifolia stimulates liver regeneration after 67% partial hepatectomy in rats.
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10

GODARA, R., S. I. RAFIQI, R. SHARMA, et al. "Acaricidal activity of Alstonia scholaris and Sida cordifolia leaf extracts against Hyalomma anatolicum ticks." Indian Journal of Animal Sciences 90, no. 11 (2021): 1461–64. http://dx.doi.org/10.56093/ijans.v90i11.111487.

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Development of acaricidal resistance and environmental pollution has driven need for eco-friendly pesticides and herbal acaricides. Leaf extracts of Alstonia scholaris and Sida cordifolia in four different solvents were used in the range of 0.25-8.0% for larval immersion test against unfed larvae of Hyalomma anatolicum. Mortality rates of larval ticks were in dose-dependent manner ranged from 0.5 to 100% for A. scholaris and from 0.8 to 100% for S. cordifolia. Acetone extract of A. scholaris and methanolic extract of S. cordifolia were most effective against larval ticks with LC50 values of 0.71% and 0.42%, respectively. Significant larvicidal activity of A. scholaris and S. cordifolia leaf extracts against unfed larvae of H. anatolicum qualify them as green pesticides which could be combined with other tools for integrated pest management.
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11

Felayati, Themas, and Hery Purnobasuki. "A NUMERICAL TAXONOMY OF Sida spp. (MALVACEAE) IN JAVA AND BALI ISLAND, INDONESIA." IRAQI JOURNAL OF AGRICULTURAL SCIENCES 53, no. 6 (2022): 1454–64. http://dx.doi.org/10.36103/ijas.v53i6.1662.

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Sida is a pantropical weed that can be annual or perennial. Several species have been identified in Indonesia. Sida cordifolia, S. rhombifolia, S. alnifolia, S. rhomboidea, S. acuta, S. glutinosa, and S. mysorensis were chosen for this study because they are representative of the species that are extensively spread in Indonesia. This study aims to update taxonomic information on the Sida genus in Indonesia. A phenogram was created using the data that was derived from the scoring of 70 morphological features. At PAST, the phenogram was created using cluster analysis, and Principal Cluster Analysis was used to determine the reason for clustering. The first cluster shows the separation of Sida acuta from all OTUs at a distance of 0.30. The second cluster shows the separation of OTU Sida cordifolia from OTU Sida glutinosa and OTU Sida mysorensis cluster at a distance between 0.20 until 0.25. The third cluster shows the separation of OTU Sida rhomboidea from OTU Sida rhombifolia and OTU Sida alnifolia cluster at a distance that was close to 0.20. The biggest value of PCA results is -0.45 and belongs to awn tip which is a character of mericarps. It demonstrates how crucial the mericarp trait is to identifying and appreciating the diversity of the genus Sida.
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12

Akilandeswari, S., R. Senthamarai, and S. Shakila Banu. "Wound healing activity of Sida cordifolia in rats." RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY 13, no. 12 (2020): 6147–49. http://dx.doi.org/10.5958/0974-360x.2020.01072.0.

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13

Sari, Ema Ratna, Netty Suharti, Friardi Ismed, and Deddi Prima Putra. "Metabolite profiling, in vitro antioxidant and xanthine oxidase inhibitory properties of six Sumatran sidaguri (Sida L.)." Journal of Pharmacy & Pharmacognosy Research 11, no. 3 (2023): 401–13. http://dx.doi.org/10.56499/jppres22.1551_11.3.401.

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Context: The Sida genus, part of the Malvaceae family, is commonly used in traditional medicine due to its many beneficial properties, such as antigout, anti-rheumatic, anti-inflammatory, antitumor, and hepatoprotective effects. Various species of Sida are found in Indonesia, particularly on the island of Sumatra, and may hold potential for future drug development. Aims: To assess and compare the methanol leaf extracts of three Sida species (S. acuta, S. rhombifolia, and S. cordifolia) from West Sumatra and South Sumatra, Indonesia, for their chemical content in metabolite profiling, in vitro antioxidant capacity, and xanthine oxidase inhibitory activity. Methods: The LC-MS/MS method was used to determine metabolite profiling, while spectrophotometry was used to assess total phenolic content, flavonoid content, antioxidant capacity, and xanthine oxidase inhibitor activity. Results: The results showed that S. rhombifolia (WS) had the highest total phenolic (64.872 ± 1.525 mg GAE/g) and flavonoid contents (13.890 ± 0.816 mg QE/g), S. acuta (SS) exhibited the highest antioxidant activity (IC50 147.295 ± 3.364 µg/mL), and S. cordifolia (WS) showed the highest xanthine oxidase inhibitor activity (IC50 110.087 ± 15.637 µg/mL). Conclusions: These findings suggest that S. acuta, S. rhombifolia, and S. cordifolia may be potential sources of polyphenols and antioxidants and could also serve as promising natural plant sources for developing antigout remedies.
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Ansong, Samuel, Desmond Nkrumah, Reinhard Isaac Nketia, et al. "Antimalarial Properties of Sida cordifolia L. Leaf Extract in Mice: Survivability Depends Less on Parasitaemia Suppression." Evidence-Based Complementary and Alternative Medicine 2023 (December 23, 2023): 1–8. http://dx.doi.org/10.1155/2023/5560711.

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Sida cordifolia has been used to treat malaria in Ghana albeit without scientific evidence of antimalarial activity and safety. This work aimed to assess the antimalarial properties and acute toxicity of the aqueous leaf extract of S. cordifolia in murine models. Aqueous extract of the plant was analysed for both suppressive and curative antimalarial properties in chloroquine-sensitive ANKA strains of rodent Plasmodium berghei-infected mice. Acute toxicity evaluation was performed in rats according to the OECD 425 guidelines. The extract displayed antiplasmodial activity in vivo with ED50 of 117.49 ± 15.22 mg/kg and 144.84 ± 18.17 mg/kg in suppressive and curative studies, respectively. The highest % parasitaemia suppression exerted was 76.90 ± 0.64% and 61.50 ± 0.97%, respectively, in the suppressive and curative studies. Survival of infected mice treated with the extract was significantly prolonged. This was dependent on the dose of the extract but imperfectly related to the % parasitaemia suppression. Related antimalarial parameters including percentage hematocrit, changes in body weight, and temperature of experimental mice indicated alleviation of malarial symptoms of treated animals. The extract did not show toxicity in rats. Sida cordifolia L. has antimalarial properties, and was safe. It suppressed parasitaemia in both suppressive and curative studies, was not toxic to animals and prolonged the life of infected animals under treatment. This, therefore, justifies the traditional use of S. cordifolia for the treatment of malaria in Ghana.
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Padmanabhan, Deepthi, Purushothaman Natarajan, and Senthilkumar Palanisamy. "Integrated Metabolite and Transcriptome Profiling-Mediated Gene Mining of Sida cordifolia Reveals Medicinally Important Genes." Genes 13, no. 10 (2022): 1909. http://dx.doi.org/10.3390/genes13101909.

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Sida cordifolia is a medicinal shrub that is conventionally used in the Indian system of medicine;however, the genes contributing to its medicinal properties have been minimally explored, thus limiting its application. High-throughputsequencing and Liquid Chromatography with tandem mass spectrometry(LC-MS/MS) technologies were applied to unravel the medicinally important bioactive compounds. As a result, transcriptomic sequencing generated more than 12 GB of clean data, and 187,215 transcripts were obtained by de novoassembly. These transcripts were broadly classified into 20 classes, based on the gene ontology classification, and 6551 unigenes were annotated using Kyoto Encyclopedia of Genes and Genomes (KEGG) database with more than 142 unigenes involved in the biosynthesis of secondary metabolites. LC-MS/MS analysis of three tissues of Sida cordifolia revealed that acacetin and procyanidin are some important metabolites identified thatcontribute to its medicinal value. Several key enzymes witha crucial role in phenylpropanoid and flavonoid biosynthetic pathways were identified, especially phenylalanine ammonia lyase, which might be an important rate-limiting enzyme. Real-Time Quantitative Reverse Transcription Polymerase chain reaction (qRT-PCR) analysis revealed enzymes, such as Phenylalanine ammonia lyase (PAL), Cinnamyl alcohol dehydrogenase 1 (CAD), Cinnamoyl-CoA reductase 1 (CF1) and Trans cinnamate 4-monooxygenase(TCM), which were predominantly expressed in root compared to leaf and stem tissue. The study provides a speculative insight for the screening of active metabolites and metabolic engineering in Sida cordifolia.
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Pawar, RajeshS, PradeepK Chaurasiya, Harish Rajak, PradeepK Singour, FedelicAshish Toppo, and Ankit Jain. "Wound healing activity of Sida cordifolia Linn. in rats." Indian Journal of Pharmacology 45, no. 5 (2013): 474. http://dx.doi.org/10.4103/0253-7613.117759.

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17

., Ranajit Kumar Sutrad, AKM Matior Rahman ., Mesbahuddin Ahmad ., Sitesh Chandra Bacha ., and Achinto Saha . "Analgesic and Anti-inflammatory Principle from Sida cordifolia Linn." Journal of Biological Sciences 6, no. 1 (2005): 160–63. http://dx.doi.org/10.3923/jbs.2006.160.163.

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18

Varghese, Anuja. "PRELIMINARY PHYTOCHEMICAL EVALUATION OF ROOT OF SIDA CORDIFOLIA LINN." International Journal of Advanced Research 6, no. 7 (2018): 573–76. http://dx.doi.org/10.21474/ijar01/7400.

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19

Sutradhar, R. K., A. K. M. M. Rahman, and M. U. Ahmad. "Three new flavonol C-glycosides from Sida cordifolia Linn." Journal of the Iranian Chemical Society 4, no. 2 (2007): 175–81. http://dx.doi.org/10.1007/bf03245964.

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20

Medeiros, I. A., M. R. V. Santos, N. M. S. Nascimento, and J. C. Duarte. "Cardiovascular effects of Sida cordifolia leaves extract in rats." Fitoterapia 77, no. 1 (2006): 19–27. http://dx.doi.org/10.1016/j.fitote.2005.06.003.

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Singh, Ajai, and Rishi Sahu. "Seedling Morphology and its Systematic Implications Within the Genus Sida L. (Malvaceae)." Indian Journal of Forestry 37, no. 1 (2014): 73–80. http://dx.doi.org/10.54207/bsmps1000-2014-4446pg.

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Investigations on seedlings of Sida acuta Burm. f. subsp. acuta, S. cordifolia L., S. javensis Cav., S. ovata Forssk., S. rhombifolia L., and S. spinosa L. have been carried out to assess the systematic relevance of seedling morphology within the genus Sida L. The seedlings are found distinct with respect to collet shape, paracotyledon blade apex, epicotyl surface, stipule, leaf blade shape and venation, type of hairs, and presence or absence of spines. The results on morphological attributes of seedlings in the genus Sida L. are of high systematic value of the family Malvaceae.
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Munmun, Mondal, and Niyogi Partha. "Sida cordifolia Linn- An widely used herbs in the village of Falta, west Bengal, India: Pharmacological evaluation of antiepileptic activity of root extract of Sida cordifolia Linn." World Journal of Advanced Research and Reviews 24, no. 1 (2024): 978–82. https://doi.org/10.5281/zenodo.15019303.

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As per the observation of the social work activitist it was found that the raw extract of the root of&nbsp;<em>Sida cordifolia&nbsp;</em>Linn. Are been used by some old people in the village of Falta Block of South 24 PGS district of West Bengal, India to treat epileptic attack on some villagers. The identified plant were collected and handed over the research scientists for the further study. The dried coarse powder of the root of&nbsp;<em>Sida cordifolia&nbsp;</em>Linn. Were soxheleted successively with petroleum ether (PESC), methanol (MESE), with boiled water (AESC) and the epileptic study was performed on the Albino mice using 100 and 300 mg/kg body weight of PESC, MESE and using clonazepam as standard using Maximum Electroshock induced seizure model and result depicted that PESC exhibited a significant antiepileptic effect at both low and high doses where as MESC exhibited the significant antiepileptic effect only at high dose. Hence, the petroleum ether extract may be chosen to be more effective than that of the methanol extract.
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Munmun Mondal and Partha Niyogi. "Sida cordifolia Linn- An widely used herbs in the village of Falta, west Bengal, India: Pharmacological evaluation of antiepileptic activity of root extract of Sida cordifolia Linn." World Journal of Advanced Research and Reviews 24, no. 1 (2024): 978–82. http://dx.doi.org/10.30574/wjarr.2024.24.1.3122.

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As per the observation of the social work activitist it was found that the raw extract of the root of Sida cordifolia Linn. Are been used by some old people in the village of Falta Block of South 24 PGS district of West Bengal, India to treat epileptic attack on some villagers. The identified plant were collected and handed over the research scientists for the further study. The dried coarse powder of the root of Sida cordifolia Linn. Were soxheleted successively with petroleum ether (PESC), methanol (MESE), with boiled water (AESC) and the epileptic study was performed on the Albino mice using 100 and 300 mg/kg body weight of PESC, MESE and using clonazepam as standard using Maximum Electroshock induced seizure model and result depicted that PESC exhibited a significant antiepileptic effect at both low and high doses where as MESC exhibited the significant antiepileptic effect only at high dose. Hence, the petroleum ether extract may be chosen to be more effective than that of the methanol extract.
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24

Laouali, Abdou, Sani Tari Abdoul Razak, and Moutari Achirou. "Impacts de l’envahissement de Sida cordifolia L. sur la diversité herbacée d’un parcours pastoral sahélien : la vallée du Goulbi N’Kaba de Mayahi au Niger." European Scientific Journal, ESJ 18, no. 11 (2022): 319. http://dx.doi.org/10.19044/esj.2022.v18n11p319.

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L’espèce végétale Sida cordifolia pose de sérieux problèmes pour les systèmes d’élevage. Son développement réduit particulièrement, la disponibilité du fourrage dans les aires de pâture en voix de dégradation et les couloirs de passage. Cette étude a pour but d’évaluer les impacts de développement de l’espèce sur la diversité des plantes herbacées autour de la vallée de Goulbi N’Kaba de Mayahi. Des relevés phytosociologiques ont été effectués dans quatre (4) communes à travers la méthode des points quadrats, sur des sites soumis et non soumis à la lutte physique contre cette plante envahissante. Elle se révèle la plus compétitive vis-à-vis des autres herbes dans les sites non soumis à la lutte, avec une contribution spécifique de 35,43%. La méthode de lutte physique utilisée s’avère rentable en réduisant le recouvrement de S. cordifolia de 35,43% à 4,71%. La diversité est faible dans les sites non soumis à la lutte contre S. cordifolia (H = 2,5). Elle est moyenne dans les sites soumis à la lutte (H=3,1). Les deux types de sites présentent peu d’espèces communes (JACCARD (Pj) = 40% soit 0,4). Cette étude a contribué à la connaissance des impacts de S. cordifolia sur la diversité herbacée de la zone concernée et contribuera sans doute à élaborer des stratégies de lutte efficace contre cette herbe envahissante qui impacte négativement le développement des espèces fourragères.&#x0D; The plant species Sida cordifolia poses serious problems for livestock systems. Its development particularly reduces the available fodder in the pasture areas in the path of degradation and the corridors of passage. The aim of this study is to assess the impacts of the development of the species on the diversity of herbaceous plants around the Goulbi N'Kaba valley of Mayahi. Phytosociological surveys were carried out in four (4) municipalities using the quadrat point method, on sites subject and not subject to the physical fight against this invasive plant. It is found to be the most competitive against other grasses in sites not subject to control, with a specific contribution of 35.43%.The physical control method used was effective by reducing the recovery of S. cordifolia from 35.43% to 4.71%. Diversity is low in sites not subject to control of S. cordifolia (H = 2.5). It is average in the sites subject to control (H=3.1). The two types of sites have few common species (JACCARD (Pj) = 40% or 0.4). This study has contributed to the knowledge of the impacts of S. cordifolia on the herbaceous diversity of the area concerned and will undoubtedly contribute to the development of effective control strategies against this invasive weed which negatively impacts the development of forage species.
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RAGHAV, ASHA, and PAWAN K. KASERA. "Seed germination potential in Sida cordifolia Linn.– A medicinal flannel weed from Indian arid zone." Journal of Medicinal and Aromatic Plant Sciences 35, no. 4 (2013): 154–58. http://dx.doi.org/10.62029/jmaps.v35i4.raghav.

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Sida cordifolia is an important medicinal plant of the Indian Thar desert. The present study deal s with the eval uation of seed germination and seedling growth behaviours of S. coedifolia under controlled (in-vitro) and natural (in-vivo) conditions. Results revealed that seeds require a scarification pretreatment of 30 minutes with concentrated H2SO4 to obtain maximum germination. Maximum seedling quality index (SQI) values were obtained when seeds were sown at 0.5 cm depth in 2:2:1 soil mixture ratio of sand: clay: FYM.
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ram, Dr Sukha, Prof Mita Kotecha, Dr Krutika Chaudhary, and Dr Neha Prajapati. "Phyto- pharmacognostic Analysis Of Ayurvedic Medicine Bala (Sida Cordifolia Linn.)." International Research Journal of Ayurveda & Yoga 03, no. 07 (2020): 43–57. http://dx.doi.org/10.47223/irjay.2020.3702.

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Galal, Ahmed, Vijayasankar Raman, and Ikhlas A. Khan. "Sida cordifolia, a Traditional Herb in Modern Perspective – A Review." Current Traditional Medicine 1, no. 1 (2015): 5–17. http://dx.doi.org/10.2174/2215083801666141226215639.

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Nunes, Xirley Pereira, Gabriela Lemos de Azevedo Maia, Jackson Roberto Guedes da Silva Almeida, Fillipe de Oliveira Pereira, and Edeltrudes de Oliveira Lima. "Antimicrobial activity of the essential oil of Sida cordifolia L." Revista Brasileira de Farmacognosia 16 (December 2006): 642–44. http://dx.doi.org/10.1590/s0102-695x2006000500010.

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Momin, Mohammad Abdul Motalib, Sm Faysal Bellah, Sarder Mohammad Raussel Rahman, Ahmed Ayedur Rahman, Gazi Mohammad Monjur Murshid, and Talha Bin Emran. "Phytopharmacological evaluation of ethanol extract of Sida cordifolia L. roots." Asian Pacific Journal of Tropical Biomedicine 4, no. 1 (2014): 18–24. http://dx.doi.org/10.1016/s2221-1691(14)60202-1.

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Sivanesan, I., and Byoung Ryong Jeong. "Direct shoot regeneration from nodal explants of Sida cordifolia Linn." In Vitro Cellular & Developmental Biology - Plant 43, no. 5 (2007): 436–41. http://dx.doi.org/10.1007/s11627-007-9090-1.

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Krizevski, R., and E. Lewinsohn. "GERMINATION OF BALA (SIDA CORDIFOLIA L., MALVACEAE), AN AYURVEDIC PLANT." Acta Horticulturae, no. 860 (February 2010): 219–22. http://dx.doi.org/10.17660/actahortic.2010.860.33.

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Khurana, Navneet, Neha Sharma, Shailendra Patil, and Asmita Gajbhiye. "AMELIORATIVE EFFECT OF SIDA CORDIFOLIA L. AGAINST SCOPOLAMINE-INDUCED COGNITIVE DEFICIT MICE MODEL." Asian Journal of Pharmaceutical and Clinical Research 10, no. 16 (2017): 70. http://dx.doi.org/10.22159/ajpcr.2017.v10s4.21340.

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Objective: In this study, ameliorative effect of aqueous extracts of Sida cordifolia and hydroethanolic extracts of S. cordifolia L. (AESC and EESC, respectively) was evaluated against scopolamine (Sco)-induced amnesia in mice. S. cordifolia L. is a well-know Ayurvedic plant which has been administered anciently for various nervous disorders including loss of memory. Female Swiss albino mice were used for Sco-induced amnesia model and acute toxicity study.Methods: Acute toxicity study was carried out to select safe and effective doses (50, 100 and 250 mg/kg; p.o.) of AESC and EESC for further pharmacological evaluation. The AESC and EESC at selected doses and donepezil (Dpl) (5 mg/kg; p.o.) were administered to different groups for consecutive 15 days. On 15th day of treatment, Sco (0.4 mg/kg, intraperitoneally) was administered to different groups for induction of amnesia. Mice were subjected to transfer latency (TL) and step down latency (SDL) tests on the 16th day to evaluate the effect of AESC and EESC on memory.Results: Sco treatment caused a significant increase in TL and decrease in SDL. The EESC significantly and dose dependently reversed the Sco-induced amnesia. The maximum effect was seen in EESC (100 mg/kg) treated group. This effect of EESC was comparable to the group treated with Dpl. The group treated with varying doses of AESC showed no significant effect on TL and SDL.Conclusion: These findings suggested the possible therapeutic potential of EESC (70%) for diseases related to memory dysfunctions like dementia in Alzheimer’s disease.
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Albert, L. H. B., and R. Victoria Filho. "Micromorfologia Foliar de Espécies de Sida spp. (guanxumas)." Planta Daninha 20, no. 3 (2002): 337–42. http://dx.doi.org/10.1590/s0100-83582002000300002.

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A eficácia dos herbicidas aplicados à folha é influenciada pela morfologia da superfície foliar que recebe a calda. A topografia da superfície foliar, o grau e o tipo da formação da cera epicuticular e a presença, tipo e distribuição de tricomas são características que influenciam a distribuição da calda pulverizada sobre a superfície foliar e, conseqüentemente, a eficácia do controle da planta daninha. Diante desses fatos, o presente trabalho teve como objetivo conhecer morfologicamente a superfície foliar de três espécies de guanxuma (Sida rhombifolia , Sida glaziovii e Sida cordifolia ). A pesquisa foi desenvolvida no Núcleo de Apoio à Pesquisa em Microscopia Eletrônica Aplicada à Pesquisa Agropecuária (NAP/MEPA), instalada na ESALQ/USP-Piracicaba/SP. As amostras biológicas foram fixadas, posteriormente desidratadas, secas ao ponto crítico e recobertas com ouro. Após a evaporação com metal, as amostras das folhas foram observadas em microscópio eletrônico de varredura Zeiss, operando entre 5 e 15 kV. Verificou-se que a superfície adaxial das espécies S. rhombifolia e S. glaziovii apresentou tricomas estelares e simples (não-ramificados), tanto curtos como longos, e também glandulares simples, tanto curtos como longos; S. glaziovii apresentou a maior quantidade destes. A espécie que apresentou maior presença de ceras epicuticulares foi S. rhombifolia, cuja aparência é estriada e a orientação aleatória. Das três espécies, S. cordifolia foi a que mostrou menor quantidade de tricomas, possuindo na superfície adaxial predominantemente tricomas simples e/ou com duas ramificações e também tricomas glandulares simples e curtos. A cutícula apresentou superfície plana e lisa, sem o aspecto estriado das outras duas espécies analisadas. Todas as espécies são anfiestomáticas, com predominância do tipo anomocítico, que é característico da família Malvaceae.
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Ahirrao, Pallavi, Rushikesh Tambat, Anjoo Kamboj, Upendra K. Jain, and Hemraj S. Nandanwar. "MODULATION ACTIVITY OF SIDA CORDIFOLIA L. AND SIDA RHOMBIFOLIA L. IN STAPHYLOCOCCUS AUREUS SA-1199 B." International Research Journal Of Pharmacy 10, no. 10 (2019): 115–21. http://dx.doi.org/10.7897/2230-8407.1010309.

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Carvalho, S. L., and R. A. Pitelli. "Levantamento e análise fitossociológica das principais espécies de plantas daninhas de pastagens da região de Selvíria (MS)." Planta Daninha 10, no. 1-2 (1992): 25–32. http://dx.doi.org/10.1590/s0100-83581992000100001.

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O presente trabalho trata do levantamento e análise fitossociológica de espécies de plantas daninhas, tóxicas ou não, infestantes de pastagens, no município de Selvíria, Estado de Mato Grosso do Sul. Para tanto, foram realizadas visitas periódicas às áreas infestadas, tendo sido coletadas excicatas para identificação botânica em dez fazendas da região. O levantamento foi tanto de natureza quantitativa como também de natureza qualitativa. Foram identificadas 73 espécies de plantas, havendo poucas espécies com distribuição generalizada. A família MALVACEAE foi a que apresentou o maior número de indivíduos e a maior densidade, enquanto que as famílias ASTERACEAE e LEGUMINOSAE apresentaram maior número de espécies nas áreas estudadas. As espécies mais abundantes foram Sida rhombifolia var. typica K. Schum e Sida cordifolia L., ambas classificadas como indivíduos solitários (sol). A espécie com maior freqüência foi S. cordifolia L. com 64,5% em relação à área total estudada. O coeficiente de similaridade para as localidades estudadas variou de 21,6% até 80%, com média de 55,8 ± 1,95% (desvio padrão da média). Foram também identificadas diversas espécies tóxicas ou suspeitas de intoxicação ao gado.
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Borchard, Jillian, Lily Mazzarella, and Kevin Spelman. "A review of medicinal plants that modulate nitric oxide activity." Alternative Medicine Studies 2, no. 1 (2012): 6. http://dx.doi.org/10.4081/ams.2012.e6.

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Modulation of nitric oxide (NO) may offer novel approaches in the treatment of a variety of diseases, such as Alzheimer’s, cardiovascular disease, and diabetes. A strategy in the modulation of NO expression may be through the use of herbal medicines. We surveyed medicinal plant research that utilized multicomponent extracts similar to what is used in clinical phytotherapy or in commerce, for demonstrated effects on NO activity. SciFinder Scholar, Pubmed, Web of Science, and BIOSIS were searched to identify human, animal, &lt;em&gt;in vivo&lt;/em&gt;, &lt;em&gt;ex vivo &lt;/em&gt;or &lt;em&gt;in vitro&lt;/em&gt; research on botanical medicines, in whole or standardized form, that act on nitric oxide activity. iNOS was the most frequently investigated enzyme system and this system was up-regulated by many plant extracts, including, &lt;em&gt;Chicorium intybus, Cocos nucifera, Echinacea purpurea, Euonymus alatus, Ixeris dentate, Oldenlandia diffusa, Rhinacanthus nasutus, and Sida cordifolia. Many plant extracts down-regulated iNOS, including Centella asiatica, Dichroa Febrifuga, Echinacea purpurea, Evolvulus alsinoides, Fagonia cretica, Ginkgo biloba, Mollugo verticillata, Lactuca indica, Lithospermum erythrorhizon, Pueraria thunbergiana, and Taraxacum officinale&lt;/em&gt;. The eNOS system was stimulated by &lt;em&gt;Eucommia ulmoides, Sida cordifolia&lt;/em&gt;, and &lt;em&gt;Thymus pulegioides while Fagonia cretica, Rubia cordifolia&lt;/em&gt; and &lt;em&gt;Tinospora cordifolia &lt;/em&gt;down-regulated nNOS. Given the activity demonstrated by many of these herbal medicines, the increasing awareness of the effects of nitric oxide on a wide variety of disease processes and the growing incidence of these conditions in the population, further study of medicinal plants on nitric oxide signaling may lead to novel therapies and further insight into human physiology.
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Boubacar Laougé, Zakari, and Hasan Merdun. "Pyrolysis and combustion kinetics of Sida cordifolia L. using thermogravimetric analysis." Bioresource Technology 299 (March 2020): 122602. http://dx.doi.org/10.1016/j.biortech.2019.122602.

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38

Bonjardim, L. R., A. M. Silva, M. G. B. Oliveira, et al. "Sida cordifolia Leaf Extract Reduces the Orofacial Nociceptive Response in Mice." Phytotherapy Research 25, no. 8 (2011): 1236–41. http://dx.doi.org/10.1002/ptr.3550.

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Imran, Mohd, R. Sahaya Jaquline, Manju Sharma, and Vidhu Aeri. "Evaluation of Sida cordifolia and Sida rhombifolia extracts in a rat model of streptozotocin-induced diabetic nephropathy." Polymers in Medicine 53, no. 1 (2023): 0. http://dx.doi.org/10.17219/pim/156847.

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SAMBO, G. Y., M. A. CHIA, D. N. IORTSUUN, and I. Y. AMAPU. "EFFECT OF SIDA CORDIFOLIA LINN. LEAF AND ROOT ETHYL ACETATE EXTRACTS ON THE GROWTH AND PHYSIOLOGICAL RESPONSE OF PANICUM REPENS AND PANICUM MAXIMUM." FUDMA Journal of Earth and Environmental Sciences 1, no. 01 (2024): 46–63. http://dx.doi.org/10.33003/jees.2024.0101/04.

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Due to the incessant application of synthetic herbicides in the agricultural system coupled with a rapid increase in herbicide-resistant weed species across the globe, much attention has been focused on alternative weed management, including allelopathy, which is eco-friendly and reduces reliance on synthetic herbicides. The effect of Sida cordifolia root and leaf ethyl acetate extract was evaluated under field conditions to determine its effects on growth, physiological response, stomatal index and density, and biochemical activity on weed species (Panicum maximum, Panicum repens, and Andropogon gayanus), as well as its effects on soil micronutrients. S. cordifolia root and leaf were collected from the wild in Nigeria and prepared into powder, which was dissolved to obtain the following concentrations 10, 20, 40, 60, and 80%, and distilled water served as the control. The percentage inhibition seems to be correlated with different growth indices as proven by an increase in malondialdehyde (MDA) content, reactive oxygen species (ROS), glutathione transferase (GST), and peroxidase (POD). Physiological growth indices such as plant height, leaf area, number of leaves, dry weight, stomatal density, and stomatal index were inhibited in both weed species while biochemical parameters such as Chlorophyll a, b, total chlorophyll and chlorophyll stability index were slightly reduced, increase in MDA, GST, ROS and POD were also noticed. In general, Andropogon gayanus showed a high inhibition rate compared to tomato. It is therefore recommended that concentrations of the Sida cordifolia extracts be increased to have a robust effect on the physiological processes of the weed species.
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Caballero, H., K. Paredes, E. Torres, and E. Segovia. "Toxicidad del extracto acuoso de Sida cordifolia L. mediante el ensayo de micronúcleo en ratones." Steviana 1, no. 13 (2022): 62–70. http://dx.doi.org/10.56152/stevianafacenv13n1a6_2021.

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Las plantas medicinales son de amplio uso en el Paraguay, la mayoría de las especies carecen de información científica sobre su uso, es por ello necesario estudiar sus efectos sobre la fisiología general, a fin de determinar sus posibles efectos secundarios. La planta Sida cordifolia (Malva blanca), hierba perenne de la familia Malvaceae, se utiliza popularmente para tratar la gripe, infecciones urinarias, inflamaciones del ovario, como emoliente, contra el enfriamiento y también se describe una actividad antinflamatoria. El objetivo de este trabajo fue determinar los efectos del extracto acuoso de la Malva blanca en eritrocitos de médula ósea de Mus musculus. Se realizó el recuento de 2.000 eritrocitos por animal para la evaluación de genotoxicidad y 500 eritrocitos por animal para la evaluación de citotoxicidad. En la evaluación de genotoxicidad del extracto acuoso de Sida cordifolia en eritrocitos de médula ósea de Mus musculus (ratones), a las concentraciones 0,01% y 0,02% no se observaron resultados significativos, en cuanto a la concentración del 0,04% se registró un nivel de significancia en comparación al control negativo. En la evaluación de citotoxicidad, se observó que todas las concentraciones utilizadas no registraron resultados significativos. El extracto acuoso de S. cordiafolia resultó genotóxica en la concentración de 0,04% pero no fue citotóxica en todas las concentraciones evaluadas.
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42

Caballero, H., K. Paredes, E. Torres, and E. Segovia. "Toxicidad del extracto acuoso de Sida cordifolia L. mediante el ensayo de micronúcleo en ratones." Steviana 13, no. 1 (2022): 62–70. http://dx.doi.org/10.56152/ffs.v13i1.2256.

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Las plantas medicinales son de amplio uso en el Paraguay, la mayoría de las especies carecen de información científica sobre su uso, es por ello necesario estudiar sus efectos sobre la fisiología general, a fin de determinar sus posibles efectos secundarios. La planta Sida cordifolia (Malva blanca), hierba perenne de la familia Malvaceae, se utiliza popularmente para tratar la gripe, infecciones urinarias, inflamaciones del ovario, como emoliente, contra el enfriamiento y también se describe una actividad antinflamatoria. El objetivo de este trabajo fue determinar los efectos del extracto acuoso de la Malva blanca en eritrocitos de médula ósea de Mus musculus. Se realizó el recuento de 2.000 eritrocitos por animal para la evaluación de genotoxicidad y 500 eritrocitos por animal para la evaluación de citotoxicidad. En la evaluación de genotoxicidad del extracto acuoso de Sida cordifolia en eritrocitos de médula ósea de Mus musculus (ratones), a las concentraciones 0,01% y 0,02% no se observaron resultados significativos, en cuanto a la concentración del 0,04% se registró un nivel de significancia en comparación al control negativo. En la evaluación de citotoxicidad, se observó que todas las concentraciones utilizadas no registraron resultados significativos. El extracto acuoso de S. cordiafolia resultó genotóxica en la concentración de 0,04% pero no fue citotóxica en todas las concentraciones evaluadas.
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43

Kumar, Sarella Prakash Nathaniel, Kanthal L.K., Durga S, Achutha Rama Raju D, and Satyavati K. "Phytochemical Evaluation and Screening of Cardiotonic, Antibacterial and Anthelmintic Activities of Sida cordifolia L." International Journal of Pharmaceutical Sciences and Nanotechnology 7, no. 3 (2014): 2567–73. http://dx.doi.org/10.37285/ijpsn.2014.7.3.10.

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&#x0D; Several herbs are traditionally used in the treatment of a variety of ailments particularly in the rural areas, where herbal medicine is mainly the source of health care system. Many of these herbs havenot been assessed for safety or toxicity to tissue or organs of the mammalian recipients. An attempt is made to prove the efficacy of Sida cordifolia Linn., (a traditional medicinal plant chosen on the basis of ethnomedical knowledge) for its Cardiotonic, Antibacterial and Anthelmintic activities. Sida cordofolia Linn., is used traditionally, inter alia, in the treatment of various infections, asthma, diarrhoea, heart and stomach disorders. Cardiotonicactivity is performed using isolated Frog Heart Perfusion Technique. Antibacterial activity of the whole plant extracts were assessed by Agar well diffusion method against the strains of Bacillus subtilis, Escherichia coli, and Staphylococcus aureus. Anthelmintic activity was studied against Pheretima posthuma. Phytochemical screening of powdered plant material revealed thepresence of some secondary metabolites such as alkaloids, saponins, tannins, glycosides and flavonoids. Results indicated that methanol, chloroform, aqueous extracts have significant cardiotonic activity but less than standard drugs. Methanol and Aqueous extracts showed high antibacterial activity and anthelmintic activity than the standard drugs. In a nutshell, we can conclude that the methanol and aqueous fractions of Sida cordifolia Linn., had a profound antibacterial and anthelmintic effect eventhough it possessed very significant cardiotonic activity. This validates its continuous usage in ethnomedicine. This plant could be developed into cheap, safe and culturally acceptable standardized herbal products and may serve as asource of new molecules for broad-spectrum antimicrobial and anthelmintic agent.
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Rajeev, S. R. Pholtan. "EFFECT OF “SITTAMATTI (SIDA CORDIFOLIA LINN.) KUDINEER (DECOCTION)” IN RESPIRATORY COMPLAINT - COUGH." International Journal of Research -GRANTHAALAYAH 8, no. 8 (2020): 24–36. http://dx.doi.org/10.29121/granthaalayah.v8.i8.2020.707.

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Background: The world is fulfilled by various medicinal plants which are widely have been used in treatment of various diseases since ancient time. Medicinal plants still play an important role in emerging and developing countries. Herbs are staging a comeback and herbal ‘renaissance’ is happening all over the globe. The herbal products today symbolize safety in contrast to the synthetics that are regarded as unsafe to human and environment. Although herbs had been priced for their medicinal, flavoring and aromatic qualities. In this research, sittamatti (Sida cordifolia) has been reported to possess analgesic, anti-inflammatory and hypoglycemic activities as well as hepato-protective activity. Traditionally the plant Sida cordifolia (Linn) has been used as CNS depressant, fat lose, analgesics, anti-inflammatory, hypotensive, hepato protective. Presence of ephedrine has highlighted the utility of this plant. various Ayurvedic preparation of this plant used in asthma diseases, etc.&#x0D; Methods: This plant spread in Mullaitivu commonly therefore utilize that as Cough decoction. First authentication of plant with experts from University of Jaffna and collecting, washing, drying and grinded for decoction preparation size. Then packing and labeling and distribute to selected 60 research samples of two groups to clinical trial and collected data through questionnaire and result analyzing in statistical way.&#x0D; Result: Group-I &amp; Group-II 1st Week (AFTER treatment) level of the samples.&#x0D; The test is significant at 0.0001 (adjusted for ties) Comparing the HT (Group-I), Research Decoction (Group-II) was shown Significant (p&lt;0.05) reduction in symptom of cough. One-month (04 Weeks) of treatment with research decoction significantly (p&lt;0.05) change symptom of cough with the control group- hospital internal treatment (HT) (group-I).&#x0D; Conclusion: effectiveness of research drugs – Sittamati Kudineer, Three months (04 Weeks) of treatment with research decoction significantly (p&lt;0.05) change symptom of cough with the control group- normal hospital internal treatment (HT) (group-I).
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Franco, C. I. F., L. C. S. L. Morais, L. J. Quintans-Júnior, R. N. Almeida, and A. R. Antoniolli. "CNS pharmacological effects of the hydroalcoholic extract of Sida cordifolia L. leaves." Journal of Ethnopharmacology 98, no. 3 (2005): 275–79. http://dx.doi.org/10.1016/j.jep.2005.01.008.

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Pawar, Rajesh Singh, Shweta Kumar, Fedelic Ashish Toppo, Lakshmi PK, and Pratibha Suryavanshi. "Sida cordifolia Linn. accelerates wound healing process in type 2 diabetic rats." Journal of Acute Medicine 6, no. 4 (2016): 82–89. http://dx.doi.org/10.1016/j.jacme.2016.08.004.

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47

Maurya Bhavna, Mishra H.S., and Agarwal Ajay Kumar. "Validation of classical pharmacology of Sida cordifolia Linn. (Bala) through reverse pharmacology." Journal of Ayurveda and Integrated Medical Sciences 9, no. 2 (2024): 204–12. http://dx.doi.org/10.21760/jaims.9.2.32.

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Bala (Sida cordifolia Linn.) belonging to the Malvaceae family is one of the most frequently used herbs in Ayurveda therapeutics. It has been included in Agraya Prakarana (best among their class drugs) which signifies its role in various diseases. In Charaka Samhita, Bala has also been categorized under Balya, Brimhaniya and Prajasthapana Mahakashaya. It is used in several diseases like Vatavyadhi, Vatarakta and acts as a Rasayana. Ephedrine, pseudoephedrine, sterculic acid, malvalic acid are its main bioactive chemical constituents. It has been demonstrated to possess various pharmacological activities like CNS depressant, analgesic, anti-inflammatory, hypotensive, antidiabetic activities and the plant is reported to be used in the treatment of Parkinson’s disease also. In classical texts, five varieties of Bala have been mentioned and all are said to possess similar properties and actions. All the varieties are abundantly available across the country. Thus, Bala becomes one of the most potent medicinal plants of present era. Present paper is an attempt towards exploration of therapeutic potential of the drug through reverse pharmacology.
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Gbenle, O. A., I. A. Taiwo, P. G. Odeigah, and O. N. Ofoma. "Genotoxic Effect of Herbal Mixture of Phyllantus amarus, Xylopica aethiopica and Sida cordifolia." University of Lagos Journal of Basic Medical Sciences 7, no. 1-2 (2019): 45–50. http://dx.doi.org/10.52968/23688704.

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Background: The herbal mixture of Phyllantus amarus, Xylopica aethiopica and Sida cordifolia is commonly used as a decoction for blood tonic. Genotoxicity has been shown in the individual plants. However, the genotoxic effect of this herbal mixture has rarely been investigated. Objective: To evaluate the genotoxic effect of herbal mixture of Phyllantus amarus, Xylopica aethiopica and Sida cordifolia using multiple genetic assay systems. Materials and Methods: Root tips of Allium cepa were treated with various concentrations of the herbal mixture (31.5, 63, 94.5 and 126mg/L) and distilled water respectively for 48 h. The root tips of A. cepa were then subjected to cytological examination using Jette Rank method. Results: Root lengths of actively growing A. cepa grown in the various concentrations of the herbal mixture decreased with increasing concentration of the herbal mixture over the experimental period. The treated roots showed various morphological abnormalities compared to the control roots grown in distilled water which showed no abnormal morphology. The herbal mixture induced various types of chromosomal and mitotic abnormalities which include binucleated cells, C-anaphase, sticky chromosomes and telophase bridges. Stickiness, vagrants and binucleated cells were the commonest of all observed aberrations as they were found at almost all concentrations of the polyherbal preparation. Frequency of aberration was found to increase with increasing herbal mixture concentration. Mitotic index decreased while mitodepression increased with increase in herbal mixture concentration. Likewise, the control had a mitotic index of 8.60%. The highest mitotic index of the mixture treated root was observed at 31.5mg/L (7.30%) and the lowest was observed at126mg/L (3.56%). Conclusion: The result suggests that the herbal mixture of Phyllantus amarus, Xylopica aethiopica and Sida cordifoliamay have genotoxic effect.
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49

Islam, Md Din, Shyama Prasad Mitra, Saswata Rabi, Emdad Hossain, and Ranajit Kumar Sutradhar. "Bioactive Flavonol C-Glycoside from Sida cordifolia L. and its Molecular Docking Study." Asian Journal of Chemistry 35, no. 6 (2023): 1429–33. http://dx.doi.org/10.14233/ajchem.2023.27636.

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Abstract:
Phytochemical studies of the aerial parts of Sida cordifolia L. has led to the isolation of a new flavonol C-glycoside, 3′-(3′′,7′′-dimethyl-2′′,6′′-octadiene)-8-C-β-D-glucosyl-kaempferol-3-O-β-D-galactoside (1) together with two known flavonoids, luteolin and quercetin. The structures of all the compounds were established on the basis of chemical and spectroscopic studies. Compound 1 was assessed to check the analgesic and anti-inflammatory activities and showed significant activities. Molecular docking study was conducted for compound 1 against 4O1Z protein receptor, which strongly support the in vitro biological findings.
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50

Franzotti, E. M., C. V. F. Santos, H. M. S. L. Rodrigues, R. H. V. Mourão, M. R. Andrade, and A. R. Antoniolli. "Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia L. (Malva-branca)." Journal of Ethnopharmacology 72, no. 1-2 (2000): 273–77. http://dx.doi.org/10.1016/s0378-8741(00)00205-1.

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