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1

Paštyková, Veronika, Josef Novotný, Tomáš Veselský, Dušan Urgošík, Roman Liščák, and Josef Vymazal. "Assessment of MR stereotactic imaging and image co-registration accuracy for 3 different MR scanners by 3 different methods/phantoms: phantom and patient study." Journal of Neurosurgery 129, Suppl1 (December 2018): 125–32. http://dx.doi.org/10.3171/2018.7.gks181527.

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OBJECTIVEThe aim of this study was to compare 3 different methods to assess the geometrical distortion of two 1.5-T and one 3-T magnetic resonance (MR) scanners and to evaluate co-registration accuracy. The overall uncertainty of each particular method was also evaluated.METHODSThree different MR phantoms were used: 2 commercial CIRS skull phantoms and PTGR known target phantom and 1 custom cylindrical Perspex phantom made in-house. All phantoms were fixed in the Leksell stereotactic frame and examined by a Siemens Somatom CT unit, two 1.5-T Siemens (Avanto and Symphony) MRI systems, and one 3-T Siemens (Skyra) MRI system. The images were evaluated using Leksell GammaPlan software, and geometrical deviation of the selected points from the reference values were determined. The deviations were further investigated for both definitions including fiducial-based and co-registration–based in the case of the CIRS phantom images. The same co-registration accuracy assessment was also performed for a clinical case. Patient stereotactic imaging was done on 3-T Skyra, 1.5-T Avanto, and CT scanners.RESULTSThe accuracy of the CT scanner was determined as 0.10, 0.30, and 0.30 mm for X, Y, and Z coordinates, respectively. The total estimated uncertainty in distortion measurement in one coordinate was determined to be 0.32 mm and 0.14 mm, respectively, for methods using and not using CT as reference imaging. Slightly more significant distortions were observed when using the 3-T than either 1.5-T MR units. However, all scanners were comparable within the estimated measurement error. Observed deviation/distortion for individual X, Y, and Z stereotactic coordinates was typically within 0.50 mm for all 3 scanners and all 3 measurement methods employed. The total radial deviation/distortion was typically within 1.00 mm. Maximum total radial distortion was observed when the CIRS phantom was used; 1.08 ± 0.49 mm, 1.15 ± 0.48 mm, and 1.35 ± 0.49 mm for Symphony, Avanto, and Skyra, respectively. The co-registration process improved image stereotactic definition in a clinical case in which fiducial-based stereotactic definition was not accurate; this was demonstrated for 3-T stereotactic imaging in this study. The best results were shown for 3-T MR image co-registration with CT images improving image stereotactic definition by about 0.50 mm. The results obtained with patient data provided a similar trend of improvement in stereotactic definition by co-registration.CONCLUSIONSAll 3 methods/phantoms used were evaluated as satisfactory for the image distortion measurement. The method using the PTGR phantom had the lowest uncertainty as no reference CT imaging was needed. Image co-registration can improve stereotactic image definition when fiducial-based definition is not accurate.
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Mzolo, Thembile, Goele Goris, Erik Talens, Alessandro Di Bucchianico, and Edwin Van Den Heuvel. "Statistical Process Control Methods for Monitoring In-House Reference Standards." Statistics in Biopharmaceutical Research 7, no. 1 (January 2, 2015): 55–65. http://dx.doi.org/10.1080/19466315.2015.1004271.

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3

Wang, Cheng. "Family House-Purchase Decision Model Based on Analytic Hierarchy Process." Applied Mechanics and Materials 423-426 (September 2013): 2973–76. http://dx.doi.org/10.4028/www.scientific.net/amm.423-426.2973.

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Housing is the basic livelihood of the residents, and the residents need to consider many factors include the price, the quality, and the surrounding environment in the house-purchase decision. Aiming at the actual problem of family house-purchase decision, this paper established a family house-purchase decision model based on Analytic Hierarchy Process (AHP). Concretely, a hierarchical chart of family house-purchase is constructed based on four factors, i.e., housing price, housing quality, supporting facilities and traffic convenience degree, and then the decision method based on AHP is given to rank the order for the alternative commercial housings. It will provide the decision reference for feasible and effective decision-making of family house-purchase.
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Benton, Sally C., Godwin K. Tetteh, Sarah-Jayne Needham, Jakob Mücke, Leanne Sheppard, Steven Alderson, Corinne Ruppen, Maurus Curti, Maurice Redondo, and Anna M. Milan. "Evaluation of the 25-hydroxy vitamin D assay on a fully automated liquid chromatography mass spectrometry system, the Thermo Scientific Cascadion SM Clinical Analyzer with the Cascadion 25-hydroxy vitamin D assay in a routine clinical laboratory." Clinical Chemistry and Laboratory Medicine (CCLM) 58, no. 6 (June 25, 2020): 1010–17. http://dx.doi.org/10.1515/cclm-2019-0834.

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AbstractBackgroundLiquid chromatography-tandem mass spectrometry (LC-MS/MS) offers advantages over immunoassay due to its increased specificity and ability to multiplex metabolites within a single run. Wide scale adoption of LC-MS/MS in routine clinical laboratories is restricted in part due to the high level of technical expertise required. The Thermo Scientific™ Cascadion™ SM Clinical Analyzer is the first fully automated, random access clinical analyser that utilises LC-MS/MS technology. We report an analytical validation of the 25-hydroxy vitamin D2 and D3 assays on the Cascadion Analyzer and an assessment of its performance within a routine clinical laboratory.MethodsAnalyser usability was assessed by staff with no previous experience of LC-MS/MS. An analytical validation included analysis of 154 patient samples on two different Cascadion Analyzers and a four-way method comparison of 146 patient samples on Roche and Siemens immunoassays and an in-house LC-MS/MS method. Accuracy was assessed using external quality assurance and reference materials. Seven third party IQC materials were tested on Cascadion.ResultsCascadion proved easy to use by scientific and non-scientific staff. The assay passed all validation criteria. Excellent agreement was demonstrated between two different Cascadions (y = 0.97x + 3.9 nmol/L, r2 > 0.99). A method comparison demonstrated no significant difference (p > 0.05) between the Cascadion and the Roche immunoassay. A significant difference (p < 0.0001) was observed between the Cascadion and an LC-MS/MS and Siemens methods. Results obtained from EQA and reference material showed a mean bias of +3.09% and all samples were within ±10% of assigned concentrations. All third party IQC samples tested were compatible for use with Cascadion.ConclusionsThe Cascadion Analyzer is a fully automated LC-MS/MS system that requires no prior LC-MS/MS expertise. The vitamin D assays demonstrated excellent performance with high levels of accuracy.
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Widyassari, Adhika Pramita, and Teguh Yuwono. "Sistem Pendukung Keputusan Pemilihan Rumah di Kawasan Cepu Menggunakan Analytical Hierarchy Process." INTENSIF: Jurnal Ilmiah Penelitian dan Penerapan Teknologi Sistem Informasi 3, no. 1 (February 1, 2019): 10. http://dx.doi.org/10.29407/intensif.v3i1.12442.

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Strategies to buy a house, consumers often experience problems in determining the house to be purchased, because each house has different characteristics. These characteristics will be used as reference considerations in determining which house to buy. In this study, the AHP (Analytical Hierarchy Process) method was used to weight the criteria and test the level of consistency with the pairwise comparison matrix. If the matrix has been consistent, then it can be continued to rank to determine the chosen alternative by using input weighting criteria obtained from the AHP method. To overcome the above problems, it is necessary to build a decision support system by implementing a ranking that can make it easier to determine House Selection using the AHP (Analytical Hierarchy Process) method. Of the 9 sample houses in the Cepu area, the highest was the Housing of Zam Zam Cepu Type 38/78 with a total value of 2,84564719.
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Post, Robert L. "A Primer on the Federal Budget Process." MRS Bulletin 15, no. 11 (November 1990): 35. http://dx.doi.org/10.1557/s0883769400058322.

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The federal budget process is often regarded as an arcane affair, the province of a select group of Washington insiders. This includes the mysteries behind the determination of budgets for R&D on materials. The purpose of this discussion is to demysrify the subject a little. It will focus largely on the role of Congress.A common misconception is that the White House sets the budget for the federal government. What the White House does do is send detailed recommendations to Congress each year in January on what it believes the budget should be. This covers spending, tax policy, and economie predictions (the latter reflected in the anticipated tax revenues). In January 1990, for example, the administration submitted budget recommendations for fiscal year 1991, which began on October 1 and runs until September 30, 1991. These recommendations (with subsequent negociations with the Hill) can be quite influential, but serve primarily as a point of reference, which Congress can gladly accept, or completely ignore, as circumstances and preferences dictate.
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Hoq, Monsurul, Susan Matthews, Vicky Karlaftis, Janet Burgess, Susan Donath, John Carlin, Vera Ignjatovic, and Paul Monagle. "Validation of the HAPPI Kids Continuous Age-Specific Pediatric Reference Intervals." Journal of Applied Laboratory Medicine 5, no. 6 (April 19, 2020): 1337–44. http://dx.doi.org/10.1093/jalm/jfaa045.

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Abstract Introduction To facilitate best possible patient care, reference intervals (RIs) adopted by a laboratory must be appropriate for the population demographics and, where applicable, the analytical principle and/or the analytical instrument used. While guidelines from the Clinical and Laboratory Standard Institute (CLSI) recommend a validation process for discrete RIs, there are no current recommendations for the validation process for continuous RIs. This study aimed to validate recently published, HAPPI Kids continuous RIs, in a routine laboratory. Methods Initially, the difference in test results between the primary study laboratory that contributed to previous RIs development and a routine laboratory was assessed using specimens from 77 children tested in both laboratories using the Siemens ADVIA 1800 or Centaur/XP/XPT. Later, validation of the HAPPI Kids RIs was undertaken using 279 pediatric samples tested on the same analyzer type in the routine laboratory. The previously published RIs were validated if more than 90% of results in the routine laboratory were within the RIs. Results There was minimal evidence of clinically significant differences in test results between the primary and routine laboratories. The continuous RIs were validated after initial analysis for 16 of the 18 biochemistry analytes tested, and after secondary analysis for the remaining 2 analytes. Conclusion This study validates the HAPPI Kids RIs in a routine laboratory, satisfying the laboratory accreditation requirements for evaluation, implementation, and sourcing of RIs. In addition, this study presents a modification of the current CLSI method for validation of continuous RIs that will benefit routine laboratories in general.
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Kulle, Alexandra E., Thomas Reinehr, Gunter Simic-Schleicher, Nadine C. Hornig, and Paul-Martin Holterhus. "Determination of 17OHPreg and DHEAS by LC-MS/MS: Impact of Age, Sex, Pubertal Stage, and BMI on the Δ5 Steroid Pathway." Journal of Clinical Endocrinology & Metabolism 102, no. 1 (November 3, 2016): 232–41. http://dx.doi.org/10.1210/jc.2016-2849.

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Abstract Background: Dehydroepiandrosterone sulfate (DHEAS) and 17-hydroxypregnenolone (17OHPreg) are important for understanding the Δ5 pathway (e.g., in adrenarche and obesity). Although mass spectrometry has become the state-of-the-art method for quantifying steroids, there are few comprehensive age-, sex-, and pubertal stage–specific reference ranges for children. Aims: To develop a sensitive and reliable ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for simultaneous quantification of DHEAS and 17OHPreg and to establish entire age-, sex- and pubertal stage–specific reference ranges in children. Methods: A total of 684 children, 453 (243 female, 210 male) with normal body mass index (BMI; &lt;90th) and 231 (132 female, 99 male) obese subjects (&gt;97th), were categorized into 11 age groups, and age- and Tanner stage (PH)–specific reference ranges were determined. Results: The limit of detection was 0.05 nmol/L for 17OHPreg and 0.5 nmol/L for DHEAS. Levels of both steroids declined after the neonatal period. Comparisons with RIA assays (Siemens, Munich, Germany) (DHEAS) and an in-house kit (17OHPreg) revealed 0.95 and 0.93, respectively, as coefficients of determination. Although DHEAS—generally higher in boys—increased continuously starting at 3 to 6 years, 17OHPreg remained largely constant. In obese patients, both were significantly elevated, also in part after alignment to Tanner stages (PH). Conclusions: UPLC-MS/MS is sensitive and reliable for quantifying DHEAS and 17OHPreg. Our data support differential maturation of CYP17 during adrenarche with successively increasing 17,20-lyase activity but largely constant 17α−hydroxylation activity. Endocrine interpretation of 17OHPreg and DHEAS must consider differential patterns for age, sex, pubertal stage, and BMI.
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Muhammad, Nor Azura, Zunaide Kayun, Hasyma Abu Hassan, Jeannie Hsiu Ding Wong, Kwan Hoong Ng, and Muhammad Khalis Abdul Karim. "Evaluation of Organ Dose and Image Quality Metrics of Pediatric CT Chest-Abdomen-Pelvis (CAP) Examination: An Anthropomorphic Phantom Study." Applied Sciences 11, no. 5 (February 25, 2021): 2047. http://dx.doi.org/10.3390/app11052047.

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The aim of this study is to investigate the impact of CT acquisition parameter setting on organ dose and its influence on image quality metrics in pediatric phantom during CT examination. The study was performed on 64-slice multidetector CT scanner (MDCT) Siemens Definition AS (Siemens Sector Healthcare, Forchheim, Germany) using various CT CAP protocols (P1–P9). Tube potential for P1, P2, and P3 protocols were fixed at 100 kVp while P4, P5, and P6 were fixed at 80 kVp with used of various reference noise values. P7, P8, and P9 were the modification of P1 with changes on slice collimation, pitch factor, and tube current modulation (TCM), respectively. TLD-100 chips were inserted into the phantom slab number 7, 9, 10, 12, 13, and 14 to represent thyroid, lung, liver, stomach, gonads, and skin, respectively. The image quality metrics, signal to noise ratio (SNR) and contrast to noise ratio (CNR) values were obtained from the CT console. As a result, this study indicates a potential reduction in the absorbed dose up to 20% to 50% along with reducing tube voltage, tube current, and increasing the slice collimation. There is no significant difference (p > 0.05) observed between the protocols and image metrics.
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Janíček, František, Martin Mucha, Karol Česnek, and Jozef Kováčik. "Controlled Switching of the T402 Transformer in the Križovany 400kV Substation." Journal of Electrical Engineering 61, no. 1 (January 1, 2010): 11–19. http://dx.doi.org/10.2478/v10187-010-0002-y.

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Controlled Switching of the T402 Transformer in the Križovany 400kV Substation The paper deals with simulating the circumstances of switching surge and trigger current at switching-in of the T402 autotransformer recently installed in Križovany, with the tests conducted by means of ATP (Alternative Transient Program) simulation software for simulating transient electromagnetic phenomena. The target has been to determine temporal curves for the most critical surge instances against earth and between the phases and the curves for trigger current with and without surge limiters connected, and to determine by means of simulations the size and statistical frequency of switching surges and based on a controlled switching simulation, to describe the elimination of transient phenomena during the process and in reference to the simulations and to operating manual for the PSD02 Siemens control unit, suggest the required configuration settings for the unit.
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STOECK, Tomasz. "Method for testing modern common rail piezoelectric fuel injectors." Combustion Engines 186, no. 3 (September 13, 2021): 31–36. http://dx.doi.org/10.19206/ce-140246.

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The paper presents the author's own method for testing piezoelectric common rail fuel injectors, which for many years were considered non-repairable components. This was mainly due to the lack of availability of spare parts and dedicated measuring equipment, enabling full diagnostics under test bench conditions. As a result, their workshop and laboratory servicing was very limited, as effective disassembly concerned basicaly only the plunger and barrel assembly (needle with nozzle) for selected reference models. The situation has now improved to such an extent that an author’s own regeneration procedure has been proposed with the replacement of the most important controls and actuators. The tests were carried out on the example of Siemens VDO Continental PCR 2.3 fuel injectors from one engine, listing the most important stages of this process, including the correction of fuel dosage and returns.
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Batyrova, Anna S., E. M. Vasilyeva, M. I. Bakanov, and A. N. Surkov. "CHANGES OF ANGIOGENIC FACTORS AND MARKERS OF ENDOTHELIAL DYSFUNCTION IN CHILDREN AND ADOLESCENTS OF WILSON-KONOVALOV DISEASE." Medical Journal of the Russian Federation 24, no. 6 (December 15, 2018): 295–98. http://dx.doi.org/10.18821/0869-2106-2018-24-6-295-298.

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Although angiogenesis is an integral part of tumor progression, it has also been observed in different inflammatory, fibrotic, and ischemic diseases. Angiogenesis is a multifactorial process and its changes bring essential information about the status of complex pathology. Aim: evaluate the role of angiogenesis and endothelial dysfunction factors in Wilson-Konovalov disease (WKD) in children and adolescents. Methods: 19 children and adolescents with WKD were included in the study. VEGF-A, angiotensin (ANG), soluble receptors of VEGF-A (sVEGF-R1 и sVEGF-R2) and trombomodulin have been investigated in serum by enzyme immunoassay using special kits (BCM Diagnostics, USA). Other endothelial dysfunction markers as von Willebrand factor (vWf) was determined in blood plasma by immunoturbidimetry (Siemens, Germany), plasminogen (PLG) was investigated due to extended coagulation. Results: it was founded marked decreasing of VEGF-A and increasing concentration of sVEGF-R1, sVEGF-R2 in blood plasma of WKD children and adolescence by comparison of reference group. ANG did not change. Comparing the ratio of levels VEGF-A+ANG/sVEGF-R1+sVEGF-R2 (in children with WKD 16,7±1,9 and in reference group 23,0±1,6, р
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Liu, Han Zhou, and Ya Hong Zhu. "Experiences and Enlightenment in Energy-Saving of Newly-Built House from Developed Countries." Advanced Materials Research 671-674 (March 2013): 2129–34. http://dx.doi.org/10.4028/www.scientific.net/amr.671-674.2129.

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In the process to build a sustainable society, building energy consumption keeps raising with the people's living standard. Therefore, reducing building energy consumption is an important guarantee to lower the whole country's energy consumption and build an economical society. Also, the development and construction of energy-efficient building is an important guarantee to reduce building energy consumption. As newly-built house is a major part of building construction, energy consumption reduction for new house plays an influential role in the action to reduce building energy consumption. The practical experiences of new house energy-saving in the developed countries, Japan as an example, are introduced. In this paper, a support system to promote our country's newly-built house energy-saving is proposed as a scientific reference for managers from government, enterprise, industry association to make energy saving policy and development planning.
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Yongliang, Xiao. "On the Protection of Unique Modern Architecture in China." IRA-International Journal of Management & Social Sciences (ISSN 2455-2267) 15, no. 4 (October 10, 2019): 137. http://dx.doi.org/10.21013/jmss.v15.n4.p7.

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<p>Nowadays in China, the action of “Shantytown Renovation” or “Dilapidated-house Transforming” is being undergone. In the process of it, some unique modern buildings are facing a damaged situation. How to deal with the relation between protection and innovation is worth considering. Thus, this paper, from the connotation of architecture and protection, discusses the present feasible approach of protecting those unique modern buildings, based on the meanings and features of the architecture. Meanwhile, the paper attempts to provide a certain reference for our country’s planning of “Shantytown Renovation” or “Dilapidated-house Transforming”.</p>
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Maharani, Anggita, and Seka Maulidia. "Etnomatematika Dalam Rumah Adat Panjalin." WACANA AKADEMIKA: Majalah Ilmiah Kependidikan 2, no. 2 (November 1, 2018): 224. http://dx.doi.org/10.30738/wa.v2i2.3183.

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This study aims to improve the learning process at school by using culture-based learning that is ethnomatematics at the Panjalin traditional house. The purpose of this study is to explore the culture of the Panjalin community as a medium for learning mathematics. Through culture-based learning, it is expected that students can improve their mathematical learning outcomes. The results showed that there were mathematical concepts and activities at the Panjalin Traditional House. Students learn theories about mathematical concepts, then know the application of these mathematical concepts. The results of the study aimed to review the benefits of ethnomatematics-based mathematics learning that can motivate students and make the results of research on ethnomatematics at Panjalin traditional house as an alternative idea of mathematics learning outside the classroom and used as reference material for the preparation of contextual mathematical problem solving questions.
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Samin, Samin, Suyanti Suyanti, Susanna Tuning Sunanti, and Wisnu Ari Adi. "Synthesis and Certification of Lanthanum Oxide Extracted from Monazite Sand." Indonesian Journal of Chemistry 20, no. 6 (October 5, 2020): 1213. http://dx.doi.org/10.22146/ijc.44327.

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Synthesis and certification of lanthanum oxide extracted from monazite sand have been carried out. This research aimed to increase the added value of monazite sand and obtain the lanthanum oxide in-house certified reference material (CRM). Synthesis of lanthanum oxide consists of several stages, namely: monazite sand digestion, rare-earth elements hydroxide [REE(OH)3] precipitation, Ce separation, Nd separation, lanthanum oxalate precipitation, and calcination. Certification of lanthanum oxide was carried out by determining the average concentration of the oxides and its uncertainty from the seven accredited laboratories by the ISO 35-2006 statistical method. Two other minerals in the lanthanum oxide analyzed by the XRD method were cerium hydroxide [Ce(OH)3] and neodymium yttrium oxide fluoride (Nd2Y2O3F16). Lanthanum oxide certified contains ten oxides, with the two highest concentrations of La2O3 (91.662 ± 0.007)% and Nd2O3 (3.949 ± 0.002)%. Lanthanum oxide has met the qualification in-house CRM since it contained water less than 1%, was homogeneous, stable, and certified. La2O3 concentration in the lanthanum oxide in-house CRM from CSAT-BATAN, Indonesia was not significantly different in comparison to that from the Department of Chemical Engineering, Srinakharinwirot University, Thailand. Lanthanum oxide extracted from monazite sand can be used as reference material in determining the lanthanum oxide quality from the pilot plant process.
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Bozzano, Jorge Néstor, and Julio Santana. "Maison Curutchet, La Plata, Argentina." LC - 50 Years After, no. 53 (2015): 32–39. http://dx.doi.org/10.52200/53.a.p4owyvn8.

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The Maison Curutchet is the only house by Le Corbusier in America. The project was developed between 1948 to 1949 and built between 1949 to 1955 as a single-family dwelling and as a professional medical office to the well-known Dr. Pedro Domingo Curutchet in La Plata, Buenos Aires. In 2013–2014, Colegio de Arquitectos de la Provincia de Buenos Aires (CAPBA) which head office is settled there, decided to carry out a full maintenance, done with the strict criteria of minimizing the impact on the house and using as reference the original documentation. The process was coordinated by CAPBA's Enhancement Research Institute, led by the architect Pablo Mastropasqua, and directed by the architect Julio Santana.
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Riedel, Juliane, Sebastian Recknagel, Diana Sassenroth, Tatjana Mauch, Sabine Buttler, Thomas Sommerfeld, Sibylle Penk, and Matthias Koch. "Development and certification of a reference material for zearalenone in maize germ oil." Analytical and Bioanalytical Chemistry 413, no. 21 (July 21, 2021): 5483–91. http://dx.doi.org/10.1007/s00216-021-03532-z.

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AbstractZearalenone (ZEN), an estrogenic mycotoxin produced by several species of Fusarium fungi, is a common contaminant of cereal-based food worldwide. Due to frequent occurrences associated with high levels of ZEN, maize oil is a particular source of exposure. Although a European maximum level for ZEN in maize oil exists according to Commission Regulation (EC) No. 1126/2007 along with a newly developed international standard method for analysis, certified reference materials (CRM) are still not available. To overcome this lack, the first CRM for the determination of ZEN in contaminated maize germ oil (ERM®-BC715) was developed in the frame of a European Reference Materials (ERM®) project according to the requirements of ISO Guide 35. The whole process of CRM development including preparation, homogeneity and stability studies, and value assignment is presented. The assignment of the certified mass fraction was based upon an in-house study using high-performance liquid chromatography isotope dilution tandem mass spectrometry. Simultaneously, to support the in-house certification study, an interlaboratory comparison study was conducted with 13 expert laboratories using different analytical methods. The certified mass fraction and expanded uncertainty (k = 2) of ERM®-BC715 (362 ± 22) μg kg−1 ZEN are traceable to the SI. This reference material is intended for analytical quality control and contributes to the improvement of consumer protection and food safety. Graphical abstract
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Cuperschmid, Ana Regina Mizrahy, Márcio Minto Fabricio, and Júlio César Franco. "HBIM Development of A Brazilian Modern Architecture Icon: Glass House by Lina Bo Bardi." Heritage 2, no. 3 (July 12, 2019): 1927–40. http://dx.doi.org/10.3390/heritage2030117.

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Lina Bo Bardi’s Glass House (Casa de Vidro) is a National Historic Landmark designed and built in the late 1940s in São Paulo, Brazil. The house is one of the symbols of modern Brazilian mid-century architecture. It is a historiographical reference of the history of modern architecture in Brazil. This article reports the experience, outcomes, challenges, benefits, and limitations of the Heritage Building Information Modeling (HBIM) process. The HBIM was developed for Lina’s Glass House considering the following steps: modeling planning; data acquisition; model elaboration; recording of pathologies and damage; data management; documentation process. The HBIM developed includes historical information and geometric data from direct measurements, laser scanning, photographic survey, and pathologies documentation. The model allows professionals responsible for architecture, conservation, and restoration to access integrated information on projects and the current condition of the buildings easily and quickly. Good precision was achieved for important building elements, contributing to maintenance and restoration actions. This experience allowed the development of an integrated workflow of activities for collecting, processing, recording, and managing information that may serve as a baseline for future projects for the documentation of modernist buildings.
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Sugiarto, Hari. "Penerapan Metode Topsis Untuk Pemilihan Perumahan." Jurnal Teknik Komputer 7, no. 2 (July 16, 2021): 176–80. http://dx.doi.org/10.31294/jtk.v7i2.10411.

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Determining which housing to choose by consumers is influenced by many factors, including price, location, facilities, environment, and house design. The housing selection process is very important so that prospective buyers do not make the wrong choice. In this study, an assessment of housing selection load was carried out based on four main factors used as a reference in decision making, namely price, location, facilities, house design, and environment. One method that can be used to solve problems in housing selection is the TOPSIS (Technique for Orders Preference by Similarity to Ideal Solution) method which is a multi-criteria decision-making method that applies the principle that the chosen alternative must have the closest distance to the ideal positive solution and the farthest distance. with a negative ideal solution. With this method consumers can make choices or make a decision by determining the weight value for each attribute, then proceed with a ranking process that will provide the best alternative from a number of alternatives, the alternative that has the highest weight value is the alternative option that has the highest priority value. Based on this method, the ranking results will be obtained which will be used as a reference in determining decision making. The result of the calculation process of the TOPSIS method is in the form of housing selection information that is closest to the choice desired by consumers who want to have an ideal home.Keywords: housing, assessment weight, topsis
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Jürgenhake, Christoph, Christian Fechtelpeter, Roman Dumitrescu, and Daniel Heidsiek. "Optimized Process Sequences for Prototyping of Molded Interconnect Devices." Advanced Materials Research 1038 (September 2014): 19–27. http://dx.doi.org/10.4028/www.scientific.net/amr.1038.19.

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The MID technology offers a high potential for the development of innovative integrated product solutions. The integration of mechanical and electronic functions on a spatial circuit board allows the realization of modules with a high functional density and a significant degree of miniaturization. MID components are spatial injection molded parts, with their surface selectively patterned and metalized. The conventional production of MID applications by an injection molding process is time consuming and expensive. Therefore, the efforts of industry and research show the significance of MID prototyping. Our objective was to develop process overviews and matching sequences for the methodological-assisted prototyping within our MID-Laboratory (MIDLab). First of all, we developed process overviews for any suitable process operations in accordance to the MID reference process. To enable a methodological approach in the production planning, essential information has been summarized in characteristics. The characteristics include a short description of the process and its unique features and a summary of the advantages and disadvantages compared to alternative methods. In addition, the compatibility of subsequent process steps, if limited or restricted, is illustrated. Afterwards, these process steps were combined to production sequences with a focus on costs, benefits and house production. Based on the requirements of the prototype, two scenarios have been developed, covering a wide spectrum of possibilities. In both sequences emphasis has been placed on cost-optimal combinations with a high house production rate. The validation of the results was carried out by two application examples. For this reason demonstrators were designed. On the basis of these modules, the results of the developed process chains were validated.
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Siran, Zainudin, Shahriman Zainal Abidin, and Rusmadiah Anwar. "The Influence of Reference Material for Sketching Strategies and Form Establishment at the Embodiment Design Level." Environment-Behaviour Proceedings Journal 5, SI3 (December 28, 2020): 135–40. http://dx.doi.org/10.21834/ebpj.v5isi3.2546.

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This paper purposely to understand the relationship between reference materials and form the embodiment process illustrated in the design drawing sketch. To review the respondent’s design thinking characteristic and to surmise the scenario of the product development issue, a design protocol analysis put in place as a core method. Respondent behaviour throughout the design activities was recorded and analyzed through interaction design embodiment process. Analysing design activities and drawing sketch has produced some pattern which states the meaning of average design element, selected reference material, interaction behaviour, and the design process in a control situation. Keywords: Interaction, Form Embodiment, Design Thinking Process, Design Elements eISSN: 2398-4287© 2020. The Authors. Published for AMER ABRA cE-Bsby e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v5iSI3.2546
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Winkler, Wolfgang. "Fuel Cell Hybrids, Their Thermodynamics and Sustainable Development." Journal of Fuel Cell Science and Technology 3, no. 2 (August 29, 2005): 195–201. http://dx.doi.org/10.1115/1.2174069.

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The increasing demand on primary energy and the increasing concern on climatic change demand immediately a sustainable development, but still there remain open questions regarding its technical realization. The second law of thermodynamics is a very simple but efficient way to define the principle design rules of sustainable technologies in minimizing the irreversible entropy production. The ideal, but real process chain is defined by a still reversible structure or logic of the process chain—the reversible reference process chain—but consisting of real components with an irreversible entropy production on a certain level. It can easily be shown for energy conversion and for transportation that hybridization in general can indeed be a measure to meet the reversible process chain and to minimize the entropy flow to the environment. Fuel cells are principal reversible converters of chemical energy and thus a key element within hybridization. Depending on application, combined heat and power process (CHP) may be a hybridization step or only a slight improvement. There is a fundamental difference in heating a house or in supplying an endothermic chemical reaction with reaction entropy. The use of heat recovery and isolation is a necessary measure to minimize the entropy flow to the environment and can be described by a reversible reference process as well. The application of reversible reference process chains shows that hybrid systems with fuel cells are a technical feasibility to approach very closely the thermodynamic potential. This development differs from the past where the technical possibilities of materials and manufacturing limited the technology to meet reversibility and thus sustainability.
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Brodie. "The ‘Art World’ of the Auction Houses: The Role of Professional Experts." Arts 8, no. 2 (April 25, 2019): 56. http://dx.doi.org/10.3390/arts8020056.

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Auction sales of unprovenanced, likely stolen, cultural objects continue to generate controversy. But while auction houses can appear to be relatively passive agents in the sales process, providing a platform for bringing together buyers and sellers, in reality their business practices are more complex. With reference to three recent disputed auctions of cultural objects, this paper explores in more detail the ‘art world’ of auction house business practices, exploring in particular the central role of professional experts in supporting auction sales and the legal and ethical implications of their involvement.
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Kaothong, Chanainat, and Viboon Sangveraphunsiri. "Grinding Force Control of Polishing Cubic Zirconia Gem by an Automatic Faceting Machine." Applied Mechanics and Materials 415 (September 2013): 52–59. http://dx.doi.org/10.4028/www.scientific.net/amm.415.52.

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This research work is to develop a controller that combines the position and indirect force control for the gemstone polishing process. The polished gemstones are attached to the end of drop-stick of the Chula Automatic Faceting Machine. The Chula Automatic Faceting Machine has 4-axis high precision motion control and the other 2-axis for spindle and crank motion. Many gemstones (number of gemstones will depends on the size of the gemstone) can be grinded and polished simultaneously with the result of uniform size and quality. In this research work, the controller is developed based on PID motion control. The reference position of the controller for the grinding process is obtained based on the compliance force control technique with known compliance model. This reference position will specified the pressing force for the grinding process indirectly. The controller developed in-house is used for testing with Cubic Zirconia gemstone which the hardness is 8.5 Mohs. The compliance model and appropriate parameters including the minimum and maximum boundary of polishing process can be obtained experimentally. Then all parameters obtained from the experiment can be used in the controller. The uniform size and quality of the multi-stone grinding and polishing process can be obtained with this controller.
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Irwana, Chyntia, M. Safii, and Iin Parlina. "Penerapan Jaringan Saraf Tiruan dalam Menentukan Kelayakan Calon Penerima Bantuan Renovasi Rumah pada Kantor Pangulu Nagori Tangga Batu Dengan Metode Backpropogation." Prosiding Seminar Nasional Riset Information Science (SENARIS) 1 (September 30, 2019): 405. http://dx.doi.org/10.30645/senaris.v1i0.46.

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Home is one of the basic needs for humans, where the house serves as a place to shelter and shelter. Apart from having a function as a place to live, the house also functions as a place for fostering and chatting with a family. Poverty is a condition where a person is unable to fulfill his basic needs. In Nagori Tangga Batu there are still many people who have homes that are not habitable. Based on these problems, the government organized a poverty alleviation program through a home renovation route for residents of Nagori Tangga Batu village. In determining whether or not a house is suitable for renovation, it is necessary to use an Artificial Neural Network using the Backpropogation algorithm to determine whether or not the house of Nagori Tangga Batu residents is eligible for home renovation assistance. The best research with Artificial Neural Network method in determining the feasibility of recipients of home renovation assistance using the backpropagation algorithm is the model 6-3-1 with the repetition process (epoch) during training with epoch value = 1673 and MSE achievement during testing with MSE = 0.00797068 . This research is expected to be a reference for further researchers relating to the user algorithm used.
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Effing, Tim, Florian Schültke, and Eike Stumpf. "HLFC-optimized retrofit aircraft design of a medium-range reference configuration within the AVACON project." CEAS Aeronautical Journal 12, no. 2 (April 2021): 441–56. http://dx.doi.org/10.1007/s13272-021-00510-0.

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AbstractThis paper presents an approach for the design of a retrofit aircraft with integrated, optimized hybrid laminar flow control (HLFC). The basis for this research is a medium-range reference configuration derived within the German LuFo project “Advanced Aircraft Concepts” (AVACON). For the aerodynamics, an in-house-developed process chain for flow analysis is used, which requires airfoil shapes at specific sections of a known wing geometry. To improve the accuracy, pressure distributions from the 2D flow solver MSES are first aligned to high-fidelity 3D results from DLR’s TAU code for extracted airfoils. This is done by varying parameters of the transformation methods used. Subsequently, the required suction distributions are optimized based on pre-defined criteria; these include not only the aerodynamic effects but also the needed mass flows. After optimizing the HLFC system architecture concerning mass and power offtakes, a retrofit aircraft is designed with the in-house “Multidisciplinary Integrated Aircraft Design and Optimization” (MICADO) environment. Compared to the turbulent baseline, the promising potential of the HLFC technology is demonstrated. In addition, the actual benefit of the optimization approach is evaluated in the context of overall preliminary aircraft design. This is done by redesigning the aircraft with other suction distributions and HLFC system architectures. Although it is shown that the approach leads to an overall optimum, the optimization benefit remains small. This indicates the limits of the HLFC technology as a pure add-on for initially turbulent aircraft and the need for the application of new laminar wing design methods to tap the full potential of HLFC.
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Zhong, Chunling, Mengqing Zhang, Xiao Cui, and Zhe Liu. "Comprehensive Evaluation of China’s Prefabricated Decoration Cost Based on Analytic Hierarchy Process." Advances in Civil Engineering 2020 (December 15, 2020): 1–10. http://dx.doi.org/10.1155/2020/1583748.

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The development of China’s construction industry is geared towards innovating traditional decoration engineering methods and promoting efficient, energy-saving and environmental-friendly prefabricated buildings. As an important part of prefabricated architecture, the slow development of prefabricated decoration has become one of the reasons that hinder the promotion and implementation of prefabricated architecture. The core problem of business is the high prefabricated cost. Accordingly, this study aims to construct a cost evaluation system with five first- and 22 second-level indices by using analytic hierarchy process (AHP). Then, the layer-by-layer analysis was conducted. Results show that the design stage has the highest weight in the first-level index, while the second-level index has the highest weight in the decoration scale assembly rate and costs of house type change, installation labor, and production, respectively, which have the most significant influence on the prefabricated decoration cost. Considering that China’s prefabricated decoration has started late, this study uses China’s prefabricated development as an example with the hope of providing reference for developing countries.
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Kolarič, Lukáš, and Peter Šimko. "Determination of Cholesterol Content in Butter by HPLC: Up-to-Date Optimization, and In-House Validation Using Reference Materials." Foods 9, no. 10 (September 29, 2020): 1378. http://dx.doi.org/10.3390/foods9101378.

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This work deals with up-to-date optimization of cholesterol content determination when saponification and extraction procedures as well as HPLC conditions were studied. As found, optimal conditions for saponification process were identified by 15 min heating in the presence of 0.015 L of methanolic KOH solution with a concentration 1 mol/L with subsequent 0.015 L n-hexane–chloroform binary mixture (1:1, v/v) double extraction. HPLC separation consisted of isocratic elution with flow rate of 0.5 mL/min mobile phase composed of acetonitrile/methanol 60:40 (v/v) and stationary phase Zorbax Eclipse Plus C18 column 2.1 × 100 mm, 3.5 μm particle size diameters with detector wavelength 205 nm. The method passed through in-house validation criteria and its suitability was verified by analysis of butter reference materials. In final, the average content of cholesterol content in butter was determined at 2271.0 mg/kg. Thus, the method is suitable for the determination of cholesterol content in butter and probably also in other dairy products.
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Montalvão, Silmara Lima, Sandra Martins Silva Soares, Marina P. Colella, Joyce M. Annichino-Bizzacchi, Samuel de Souza Medina, and Margareth C. Ozelo. "Impact of Two Immobilized GPIbα Assays in the Diagnosis of Von Willebrand Disease." Blood 124, no. 21 (December 6, 2014): 1524. http://dx.doi.org/10.1182/blood.v124.21.1524.1524.

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Abstract The diagnosis of von Willebrand Disease (VWD) remains a challenge of daily hematology practice. Ristocetin cofactor activity (VWF:RCo) is an important parameter for the diagnosis of VWD and is also essential for its management. However, reproducibility of the available tests for VWF:RCo is still a major issue, as evidenced by coefficient of variations (CV) as high as 30%, 45% and 27% in the ECAT, NEQAS and PALQ external quality assessment program. Classical methods to measure VWF:RCo include light-transmission platelet agregometry (LPA) and visual agglutination with formaldehyde fixed human platelet (VA), and more recently, VWF activity based on automated latex immunoassay (LIA). The glycoprotein (GP) Ibα is the main receptor for von Willebrand factor (VWF) in the platelet membrane. Currently, two automated methods with immobilized GPIbα have been developed to improve the sensitivity and specificity of VWF:RCo. One of them is performed with ristocetin while the other one uses a mutant GPIbα with gain of function and does not require ristocetin. This study aims to compare the two assays using immobilized GPIbα with other four assays for VWF functional determination, in patients with confirmed and under investigation for VWD. We evaluated six different VWF functional assays: VWF:RCo LPA (Chrono-Log); VA (Siemens); VA in house (with ristocetin from Chrono-Log); automated-LIA (Hemosil); in comparison to two assays using immobilized GPIbα with or without ristocetin, the GPIbα-ristocetin (Hemosil), and GPIbα-mutant (Siemens Innovance). Reference ranges for each method were established in 20 healthy adults. Plasma samples collected at the same time from 40 individuals were used in this comparative study, with 25 type 1 VWD, 2 type 3 VWD, and 13 under investigation. Diagnosis of VWD was based on bleeding history (evaluated by MCMDM-1VWD Bleeding Score), historical levels of VWF antigen (VWF:Ag) by ELISA, and VWF:RCo (assayed by LTA or VA) obtained from medical records. Statistical analysis were performed based on linear regression (Spearman correlation), agreement test (Altman Bland), and chi-square test using Prism 6.0. When all 40 patients were evaluated for both methods, GPIbα-ristocetin and GPIbα-mutant, we observed a good coefficient of correlation (r = 0.8954; p<0.0001). However, when 7 type 1 VWD patients, and 1 under investigation case were evaluated for the six methods, the two using immobilized GPIbα showed lower median (16.78 ± 4.62 with GPIbα-ristocetin, and 16.28 ± 4.29 with GPIbα-mutant), when compared with the other four assays (LTA: 22.38 ± 5.5; VA in house: 21.45 ± 4.87; VA Siemens: 22.65 ± 4.9; and LIA: 24.19 ± 9.0). In this group, when the bleeding score (BS) were ≥ 5, the VWF functional results were lower than 25 IU/dL, using all six methods (figure). Among 13 individuals under VWD investigation, GPIbα-ristocetin and GPIbα-mutant showed good agreement with the LTA/VA results and clinical history, and we could concluded that 4 have VWD, and for 4 individuals VWD was excluded. However, 2 individuals with no history of bleeding presented abnormal results for GPIbα-ristocetin and GPIbα-mutant, showing probably false positive results. One patient with no bleeding history, and abnormal LTA/VA results had normal GPIbα-ristocetin and GPIbα-mutant results, demonstrating poor reproducibility and precisian of the classical methods. On the other hand, two patient with BS 6, the diagnosis of VWD was demonstrating only by immobilized GPIbα methods. The VWF:RCo is a cumbersome assay and can be affected by polymorphisms present in the ristocetin binding site of VWF. Recently, new technologies have been developed to improve the VWF functional evaluation. It is consensus that methodologies using platelets are more accurate than other methods. Therefore, immobilized GPIbα has the objective to improve the sensitivity and specificity. Besides good results of concordance between immobilized GPIbα in the group of VWD patients and for 62% individual under investigation, we also observed false positive results related with these methods. The presence or absence of ristocetin on the immobilized GPIbα setting appear not engender different results in this study. In general, this new technologies present better precision compared to VA and LTA. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.
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Lösler, Michael, Cornelia Eschelbach, and Stefan Riepl. "A modified approach for automated reference point determination of SLR and VLBI telescopes." tm - Technisches Messen 85, no. 10 (October 25, 2018): 616–26. http://dx.doi.org/10.1515/teme-2018-0053.

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AbstractThe International Terrestrial Reference Frame (ITRF) is derived by combining several space geodetic techniques. Basically, a meaningful combination of the geodesic space techniques is impossible without further geometrical information, i. e. local-ties. Local-tie vectors are defined between the geometrical reference points of space geodetic techniques at co-location stations. These local-ties are introduced during the inter-technique combination process, to overcome the weak physical connection between the space geodetic techniques. In particular, the determination of the reference point of radio telescopes or laser telescopes is a challenging task and requires indirect methods. Moreover, the Global Geodetic Observing System (GGOS) strives for an automated and continued reference point determination with sub-millimeter accuracy, because deviations in local-ties bias global results.This investigation presents a modified approach for automated reference point determination. The new approach extends the prior work of Lösler but evades the synchronization between the terrestrial instrument and the telescope. Thus, synchronization errors are omitted and the technical effort is reduced. A proof of concept was carried out at Geodetic Observatory Wettzell in 2018. Using a high-precision, mobile laser-tracker, the reference point of the Satellite Observing System Wettzell (SOS-W) was derived. An extended version of the in-house developed software package HEIMDALL was employed for a mostly automated data collection. To evaluate the estimated reference point, the derived results are compared with the results of two approved models.
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Grenda, Tomasz, Elżbieta Kukier, Zbigniew Sieradzki, Magdalena Goldsztejn, and Krzysztof Kwiatek. "In-House Validation of Multiplex PCR Method for Detection of Clostridium Botulinum in Food and Feed." Bulletin of the Veterinary Institute in Pulawy 56, no. 2 (June 1, 2012): 155–60. http://dx.doi.org/10.2478/v10213-012-0028-y.

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Abstract The aim of this study was to perform an in-house validation of multiplex PCR method for C. botulinum detection in food and feed samples. The study was carried out on food and feed matrixes artificially contaminated by spores of C. botulinum reference strains. The following characteristic parameters for qualitative detection were estimated: limit of detection expressed as LOD50 according to the Spearman-Kärber formula, specificity, sensitivity, and accuracy according to the PN-EN ISO 16140:2004. The validated method showed high specificity. Specific PCR products were revealed only for DNA obtained from samples contaminated with C. botulinum spores. PCR inhibition was observed, especially during examination of contaminated feed. The calculated LOD50 for feed was nearly 10 times higher than for food. The implemented method enables to obtain test results during 3 d without time- consuming process of isolation and proving the ability of strains to produce botulinum toxins.
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Maulidah, Silvana. "Risk Mitigation of Tobacco Supply Chain: Business Process Model." HABITAT 31, no. 3 (December 1, 2020): 149–60. http://dx.doi.org/10.21776/ub.habitat.2020.031.3.18.

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Tobacco and its industrial products are a massive business in international trade. As a potential agro-industry, the tobacco products industry requires a supply of raw materials that must meet quantity, quality and continuity. The complexity of the tobacco supply chain network and the rapidly changing world business dynamics, pose risks in its business processes. An optimal supply chain risk mitigation or risk management strategy needs for the resilience of the tobacco supply chain in the disruption. The purpose of this study is to analyze the level of risk priority and also to formulate a risk mitigation strategy for the tobacco supply chain through a business process model approach. The method of analysis is the Delphy method and the House of Risk (HoR). The business process adopted from the SCOR (Supply Chain Operations Reference) model. The results showed: the priority level of tobacco supply chain risk is: economic uncertainty, tobacco is not available at the farm level, the location of tobacco raw materials is far from production activities, product prices have risen due to customs and product demand has increased sharply. Supply chain risk of mitigation strategies includes: increasing the flow of information in the tobacco supply chain, managing the stock/supply of tobacco raw materials and processed products, evaluating distributor selection, establishing partnerships with tobacco farmers, implementing a marketing mix strategy (product, price, location, promotion), increasing coordination with relevant governments, and management of information systems and technology.
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Favaloro, Emmanuel. "Evaluation of commercial von Willebrand factor collagen binding assays to assist the discrimination of types 1 and 2 von Willebrand disease." Thrombosis and Haemostasis 104, no. 11 (2010): 1009–21. http://dx.doi.org/10.1160/th10-06-0360.

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SummaryThis study reports on the evaluation of seven commercial von Wille-brand factor (VWF) collagen binding (VWF:CB) assays to potentially assist the discrimination of types 1 and 2 von Willebrand disease (VWD). Samples from 25 patients with type 1 VWD, of varying severity, were co-tested with 16 samples from patients with types 2A or 2B VWD, plus various control samples, using each commercial VWF:CB assay assessed against our standard (reference) in-house VWF:CB assay, as well as our in-house VWF antigen (VWF:Ag) and ristocetin cofactor (VWF:RCo) assays. Commercial VWF:CB assays varied in their ability to discriminate types 1 and 2A/2B VWD. The optimal VWF:CB/VWF:Ag ratio at which optimal discrimination occurred also differed between assays, with some improvements observed with some (but not all) as-says following a harmonisation process that aimed to correct for different calibrator effects. Assay variability also compromised assay utility in some test occasions. Future standardisation and improvements in some commercial VWF:CB assays are needed before the VWF:CB assay can be more fully and globally utilised for discrimination of VWD types in diagnostic laboratories.
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Zhang, Jiangtao, Wenbo Luo, Jie Zeng, Tianjiao Zhang, Weiyan Zhou, Haijian Zhao, Ying Yan, et al. "Standardization of measurement procedures for serum uric acid: 8-year experience from Category 1 EQA program results in China." Clinical Chemistry and Laboratory Medicine (CCLM) 57, no. 4 (March 26, 2019): 476–82. http://dx.doi.org/10.1515/cclm-2018-0274.

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Abstract Background Serum uric acid is a critical clinical indicator, and results without equivalence among laboratories cause troubles for disease diagnosis and patient management. External quality assessment (EQA) is a common tool for enhancing harmonization/standardization, therefore, the National Center for Clinical Laboratories in China has initiated a category 1 EQA for serum uric acid measurement since 2010 for evaluating its process of standardization. Methods Commutable EQA samples with target values assigned by reference measurement procedures were sent to participant laboratories. Both concentrations were measured 15 times in 3 days then means and intra-laboratory coefficient of variations (CVs) were reported. Biological variation criteria were used for analysis with CLIA88 criteria as a comparison. Results A total of 1250 laboratories participated in EQA programs from 2010 to 2017, pass rates calculated according to desirable specifications in biological variation database were on a rise overall and inter-laboratory mean bias and CVs were on a decrease. Homogeneous systems showed better inter-laboratory CVs and pass rates than heterogeneous systems. For the mostly used measurement systems; Abbott, Beckman, Roche Modular, Siemens and Hitachi showed desirable performances other than Roche Cobas, according to biological variation criteria. Conclusions Our study provides reliable information on the standardization of measurement procedures for serum uric acid for manufacturers and laboratories. Further improvements for standardization are still needed to make laboratories more patient-centered.
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Liu, Hua, Lian-cun Zuo, and Jin-yu Chen. "Research on the Improvement Path of Agricultural Supply Quality Based on Pre-control under the "Internet +"." E3S Web of Conferences 145 (2020): 01031. http://dx.doi.org/10.1051/e3sconf/202014501031.

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By identifying the factors affecting the quality and safety in the supply chain of agricultural assets under the "Internet+", the importance of customer needs and various needs is determined by using the analytic hierarchy process and questionnaire method. Combining HACCP system with QFD principle, a quality house of agricultural assets based on quality and safety control is drawn up. The quality and safety control system of agricultural assets is established by quantifying quality and safety prevention and control measures. Through the quantitative analysis of measures adopted, the operability and emphasis of the measures are strengthened, which can provide reference and basis for improving the quality and safety of agricultural assets in the new era in China.
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Kobel, Przemysław, Leszek Romański, Jerzy Bieniek, Przemysław Bukowski, and Agnieszka Martynowicz. "Comparison of Applications Supporting Selection and Design of Household Solar Collector Systems." Agricultural Engineering 20, no. 4 (December 1, 2016): 85–99. http://dx.doi.org/10.1515/agriceng-2016-0067.

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Abstract In order to support the designing process and selection of subassemblies of an installation, specialist application programs are created. Selected applications were compared in the paper through their use for designing hypothetical solar collector systems for a single family house with a varied number of household members. With the use of particular applications, calculations for the same input assumptions were made. Results obtained with the use of a traditional calculation method were a reference point. Applications were compared on account of the type and amount of input parameters which may be introduced, type and number of determined values and their value. Based on the obtained results usefulness and scope of use of an application were assessed.
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Drogies, Tim, Till Ittermann, Jan Lüdemann, Doris Klinke, Thomas Kohlmann, Norbert Lubenow, Andreas Greinacher, Henry Völzke, and Matthias Nauck. "Potassium – reference intervals for lithium-heparin plasma and serum from a population-based cohort / Kalium – Referenzbereiche für Lithium-Heparin-Plasma und Serum aus einer bevölkerungsbezogenen Studie." LaboratoriumsMedizin 34, no. 1 (February 1, 2010): 39–44. http://dx.doi.org/10.1515/jlm.2010.002.

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AbstractBackground: Serum, as a standard material for the determination of numerous analytes, has disadvantages. The coagulation process leads to an artificial increase of the potassium concentration of approximately 0.3 mmol/L in serum samples compared to plasma. Consequently, plasma reflects the in vivo situation more accurately. The aim of the present analyses was to establish reference intervals (RIs) for potassium using data from a population-based study for serum (PS) and plasma (PP).Methods: Serum was used from 2897 subjects aged 20–79 years, participating in the 5-year follow-up of the Study of Health in Pomerania (SHIP 1), a population-based study in northeast Germany. In addition, 2483 samples (serum and plasma) from a population of blood donors (DONOR-SHIP) were used. Finally, calculated RIs were reevaluated in 202,350 potassium values from hospitalized patients. All measurements were performed on a Siemens Dimension RxL Max HM with ion-selective electrodes. Using the sample pairs from DONOR-SHIP, a regression formula for the transformation of PS to PP was calculated. This formula was applied to the serum data from SHIP 1 to calculate corresponding plasma values. RIs (2.5th and 97.5th percentile) were defined with quantile regression and bootstrap method in SHIP 1.Results: RIs for PS and PP were 3.7–5.1 mmol/L and 3.5–4.6 mmol/L, respectively. Clinically relevant age- or sex-specific tendencies were not detected. The difference between PS and PP is dependent on platelet count and potassium concentration.Conclusions: The study permitted the establishment of RIs for PS and PP on a population-based study. For serum, the influence of platelet count and absolute potassium concentration on the results should be taken into account.
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Brossaud, Julie, Monique Leban, Jean-Benoit Corcuff, Florence Boux de Casson, Anne-Gaëlle Leloupp, Damien Masson, Valérie Moal, and Kalyane Bach-Ngohou. "LC-MSMS assays of urinary cortisol, a comparison between four in-house assays." Clinical Chemistry and Laboratory Medicine (CCLM) 56, no. 7 (June 27, 2018): 1109–16. http://dx.doi.org/10.1515/cclm-2017-0806.

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Abstract Background: Twenty-four hour urinary free cortisol (UFC) determination can be used for screening and follow-up of Cushing syndrome (CS). As immunoassay methods lack specificity for UFC measurement, the use of high-performance liquid chromatography coupled to mass spectrometer (LC-MSMS) is recommended. The aim of our study was to compare UFC results using four LC-MSMS methods performed in four independent laboratories in order to evaluate interlaboratory agreement. Methods: Frozen aliquots of 24-h urine samples (78 healthy volunteers and 20 patients with CS) were sent to four different laboratories for analysis. Following liquid-liquid or solid-liquid extraction, UFC were determined using four different LC-MSMS assay. Results: UFC intra- and interassays variation coefficients were lower than 10% for each centre. External quality control results were not significantly different. UFC normal ranges (established from healthy volunteers) were 17–126, 15–134, 12–118 and 27–157 nmol/day, respectively. Classification of UFC from healthy volunteers and patients with CS using a 95th percentile threshold was similar. However, for extreme UFC values (<50 or >270 nmol/day), negative or positive bias was noted. Conclusions: Even for highly specific methods such as LC-MSMS, variations of results can be found depending on analytical process. Validation of LC-MSMS methods including determination of the reference range is essential.
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Novrial and Nila Rahmaini Siregar. "Characteristics of Vernacular Architecture Malay Deli Traditional House Based on Technical Aspects of Building Structure." International Journal of Architecture and Urbanism 5, no. 2 (August 26, 2021): 148–60. http://dx.doi.org/10.32734/ijau.v5i2.6834.

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Local wisdom in an architectural context is part of cultural heritage, passed down from generation to the next generation and gone through a long process of gaining community recognition as a reflection of the region's culture, also known as vernacular architecture. Vernacular architecture can be found in almost every region, as is the city of Medan. Medan city is famous for its culture, especially its Malay culture, formed by the Sultan of Deli's influence so that Malay Deli emerged. In its formation, aspects of the creation of vernacular architecture also influenced the development of Malay Deli, mainly traditional houses. These traditional houses is visible from one of its forming aspects in the form of technical aspects such as building structure systems. This study discusses the characteristic of system structure in the Malay Deli traditional house and aims to identify and examine these problems. This study adopted a qualitative descriptive method approach to collect and analyze data so that the results obtained in the form of technical aspects of the structure of vernacular building structures from traditional Malay. This study's findings are a reference source for traditional Malay houses' vernacular architecture, specifically Malay deli or design considerations.
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Schoch, Richard. "THE BIRTH OF SHAKESPEARE'S BIRTHPLACE." Theatre Survey 53, no. 2 (August 28, 2012): 181–201. http://dx.doi.org/10.1017/s0040557412000038.

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“There is, indeed, little doubt,” the formidable scholar James Orchard Halliwell-Phillipps confidently explained to the Victorian readers of hisOutlines of the Life of Shakespeare,“that the Birth-place did not become one of the incentives for pilgrimage until public attention had been specially directed to it at the time of the Jubilee.” That's broadly true. The earliest reference to the three-gabled, half-timbered house (two houses, originally) on Henley Street in Stratford-upon-Avon as the birthplace of William Shakespeare dates only from the late 1750s, when it was so named in Samuel Winter's town map. During the Stratford Jubilee, which David Garrick organized in 1769, the “small old house,” as the actor's first biographer called it, was fully recognized and promoted as the place where Shakespeare was born. Even so, Halliwell-Phillipps's observation conceals more than it reveals, because there is also little doubt that the dwelling that tradition calls Shakespeare's birthplace did not suddenly acquire that status during the first week of September 1769. The process by which the unremarkable piece of real estate that John Shakespeare purchased sometime in the late sixteenth century was transformed into what Barbara Hodgdon has rightly called the “controlling ideological center” of Shakespeare biography was long, slow, and far from inevitable. That process is the subject of this essay.
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Lebedeva, Yulia, Yulia Belozerova, Maria Zakharova, and Maria Volkova. "Methodological efficiency of using virtual and augmented reality in the educational process." E3S Web of Conferences 210 (2020): 18077. http://dx.doi.org/10.1051/e3sconf/202021018077.

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This article presents the results of an experiment on creating an electronic textbook for universities and programs of additional professional education using virtual and augmented reality technologies and evaluating the results of testing the textbook on the basis of the State University of Management. The topic of the electronic textbook concerns the organization of the security service of accommodation facilities. The authors provide a description of the electronic textbook, its structure, main interactive elements, the progress of work, talk about the difficulties that they encountered. The working group on the creation of the textbook included methodologists, psychologists, specialists from the security services of Moscow hotels and specialists in information technology. Teams of key developers - the State University of Management, the Lotte group of companies, the LLC ITRON limited liability company, and the Rusays Publishing House - worked in partnership. Conclusions are made about the possibilities of using virtual and augmented reality technologies in educational activities. Augmented reality technology is used to create a mobile application that displays educational materials with reference to real-life objects according to special markers. This technology allows you to make the textbook unique for a specific object (office, building, structure, landscape). The results of the training using an electronic participant are presented. The peculiarities of the psychological perception of educational material and the effectiveness of the new format of presentation of the educational environment are noted.
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Fabbri, Rita, Laura Gabrielli, and Aurora Greta Ruggeri. "Interactions between restoration and financial analysis: the case of Cuneo War Wounded House." Journal of Cultural Heritage Management and Sustainable Development 8, no. 2 (May 21, 2018): 145–61. http://dx.doi.org/10.1108/jchmsd-05-2017-0026.

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Purpose The purpose of this paper is to examine the cross-sectoral collaboration between conservation and economic appraisal, and to process a financial analysis for private owners of a built heritage. Design/methodology/approach The methodology applied addresses the financial analysis of restoration through a discounted cash flow analysis, together with a life cycle costing. Costs and revenues are both analysed in this paper. Some energy-saving measures are applied to cut running costs and decrease the energy required by the building, using as reference the “Guidelines for improving energy efficiency in cultural heritage” drafted by MiBACT, which considers the respect of restoration principles. In order to increase revenues, part of the building is rented. The attractiveness of the investment opportunity is valued through the calculation of the net present value of cash flows, the payback period and the internal rate of return. Findings The paper offers a simple strategy for the planning of cost-revenues, preventively allowing verification if the conservation is economically feasible and if the owners can afford the operation. The strategic planning will give the owners the chance of maintaining the property of their building and achieve a proper restoration on it. Originality/value The novelty of the paper is the study of cooperation between conservation and economic valuation, but also the focus on a specific portion of twentieth-century heritage, the war-wounded houses, which represent a widespread patrimony, on which it is not clear how to operate yet.
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44

Chidlow, Joyce. "Information needs of architectural practices." Art Libraries Journal 16, no. 3 (1991): 18–24. http://dx.doi.org/10.1017/s0307472200007264.

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Libraria is a small business which provides a visiting library service to architectural practices. Although practices vary, their information needs are similar, and are met from the several categories employed by Libraria to organise information materials: technical literature, trade literature, samples, consultants and contractors, company information, fine art and reference, maps, journals, and in-house material. Information from these categories must be available as required to support successive stages in the building design process from inception to completion. Library services in the construction industry have to provide the right information at the right time, without being a drain on the resources of practices which can only survive as profitable businesses; the librarian must be seen to be an ever-helpful source of practical information.
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45

Fosztó, László. "Communicating conversion: thoughts about religious change based upon experiences with Roma converted to pentecostalism." Erdélyi Társadalom 5, no. 1 (2007): 23–49. http://dx.doi.org/10.17177/77171.74.

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The present study reflects upon the process of religious conversion from the point of view of communication practices between those already converted and the person still being in the process of conversion. The analyzed ethnographic material is from a Roma community near Cluj-Napoca. Among the Roma there can be observed the dominance of Pentecostalism. One of the conclusions of the study is that the central element of the religious change lies in the change regarding ritual communication. The personal conversion goes along with the redrafting of the moral aspects of a person, and this needs the new approaches of both the verbal (testimony and conversion stories) and non-verbal communication (furnishing the house, dressing, public consumption practices, etc.). The author highlights the importance of literacy during the conversion process. For the converted the congregation represents the primary publicity, but in the same time the others (not converted) are an important reference group. The converted are influenced by the engagements related to the family and relatives, and by the tension of not giving these up
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Maslucha, Maslucha. "SISTEM PREDIKSI PENGGUNAAN LISTRIK PELANGGAN DI PT.PLN (PERSERO) RAYON LAMONGAN AREA BOJONEGORO DENGAN METODE TRIPLE EXPONENTIAL SMOOTHING (BROWN)." INDEXIA : Infomatic and Computational Intelligent Journal 1, no. 1 (April 1, 2019): 36. http://dx.doi.org/10.30587/indexia.v1i1.824.

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Electricity is one of the means of fulfilling the needs of human life which is very important in this era. Excessive use of electricity will have an impact on the high use of electricity kWh. The process of recording kWh on the customer meter is carried out by officers from PLN who routinely visit the customer's homes once a month. The meter recording clerk cannot record when the customer's house cannot be reached resulting in empty customer kWh data. Prediction System Using Electricity Customers at PT. PLN Lamongan aims to determine the amount of electricity usage kWh of the customer for the next period. This research uses the Triple Exponential Smoothing method (Brown). The calculation is done on 10 different customers with 24 data, namely the use of electric kWh per period from January 2015 to December 2016 with 9 different alpha values, namely alpha 0.1 - 0.9 and uses a reference of 3 months, 6 months and 12 months before. Prediction results will be compared with the actual data of kWh to determine the failure value or error value in predictions using mean absolute deviaton (MAD) and mean absolute percentage error (MAPE). From the third average forecasting test analysis, it produces an average MAPE value of 3 months reference with an average value of 2.922%, 6 months reference with an average value of 3.092% and a 12-month reference with an average value of 4.175%. The smallest MAPE, which is a test using a 6-month reference, produces a value of 1.886% with alpha 0.1.
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Barnett, Paul. "SUSTAINABLE MICRO-VILLAGES AND THE CARWOOLA HOUSE PROJECT IN CANBERRA, AUSTRALIA." Journal of Green Building 13, no. 4 (September 2018): 167–90. http://dx.doi.org/10.3992/1943-4618.13.4.167.

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INTRODUCTION Our needs as social and familial beings change over the course of our lives; however, it has become common practice to build as though these needs remain static through time. The needs of a child, young adult, family, middle age and the elderly are dynamic between generations, and adding to these evolving life needs is the crisis of housing affordability. Three decades ago a house could cost 3–4 times an individual's annual income, today that cost is closer to 10–12 times. In response to these challenges, this article explores the concept of Sustainable Micro-Villages, providing insight into a new approach to energy-efficient housing with reference to our case-study project—Carwoola House. Sustainable Micro-Villages can be defined as a cluster of integrated dwellings, referred to here as Living Pods. Essentially a “single house” on a single site, these micro-villages can be comprised of two or more smaller buildings that provide private dwelling space for a single person, couples, couples with children, parents, elderly, friends and any combination of social groups. Living pods cluster around a natural garden setting, enhanced by water-harvesting, and are connected with covered, open or enclosed links depending on the climate of the site. The recent iterations of this type of dwelling also incorporate solar passive design, passive house and greenhouse technology. In Australia, new house designs are evaluated as part of an approvals process for their energy rating. 1 The Australian Building Code requires a minimum 6-star rating, ranging up to 10 stars for any new home to be built. A 6-star rating provides a good level of insulation and energy performance if built correctly, while 10 stars represent the highest level of energy performance and refers to a dwelling that needs no heating or cooling. Sustainable Micro-Villages consistently achieve an 8 to 10-star rating by combining Solar Passive Design principles (good orientation, thermal mass and thermal performance) and Passive House Technology (high thermally performing building with low air leakage, no thermal bridging, high performance glazing and heat recovery ventilation) in various combinations to suit the climate, context and budget.
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Al-Hawari, Feras, Hala Barham, Omar Al-Sawaeer, Mai Alshawabkeh, Sahel Alouneh, Mohammad I. Daoud, and Rami Alazrai. "Methods to achieve effective web-based learning management modules: MyGJU versus Moodle." PeerJ Computer Science 7 (April 16, 2021): e498. http://dx.doi.org/10.7717/peerj-cs.498.

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Several higher education institutions have harnessed e-learning tools to empower the application of different learning models that enrich the educational process. Nevertheless, the reliance on commercial or open-source platforms, in some cases, to deliver e-learning could impact system acceptability, usability, and capability. Therefore, this study suggests design methods to develop effective learning management capabilities such as attendance, coordination, course folder, course section homepage, learning materials, syllabus, emails, and student tracking within a university portal named MyGJU. In particular, mechanisms to facilitate system setup, data integrity, information security, e-learning data reuse, version control automation, and multi-user collaboration have been applied to enable the e-learning modules in MyGJU to overcome some of the drawbacks of their counterparts in Moodle. Such system improvements are required to motivate both educators and students to engage in online learning. Besides, features comparisons between MyGJU with Moodle and in-house systems have been conducted for reference. Also, the system deployment outcomes and user survey results confirm the wide acceptance among instructors and students to use MyGJU as a first point of contact, as opposed to Moodle, for basic e-learning tasks. Further, the results illustrate that the in-house e-learning modules in MyGJU are engaging, easy to use, useful, and interactive.
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Batyrova, A. S., E. M. Vasilieva, M. I. Bakanov, and A. N. Surkov. "BIOMARKERS OF ANGIOGENESIS AND ENDOTHELIAL DYSFUNCTION IN CHILDREN AND ADOLESCENTS WITH CHRONIC VIRAL HEPATITIS." Russian Clinical Laboratory Diagnostics 64, no. 10 (October 15, 2019): 588–93. http://dx.doi.org/10.18821/0869-2084-2019-64-10-588-593.

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At some works, it has been shown there are signs of damage and endothelium dysfunction in patients with chronic viral hepatitis (CVH) and liver cirrhosis of viral etiology the severity of these conditions depends on the severity of the pathological process. Evaluation of the role of angiogenic factors and endothelial dysfunction in persistent of CVH in children and adolescents. 35 patients were examined: of which 11 with chronic hepatitis B (CHB) and 24 with chronic hepatitis C (CHC). The reference group consisted of 120 practically healthy persons of the corresponding age and sex. VEGF-A, angiotensin (ANG), soluble receptors of VEGF-A (sVEGF-R1 и sVEGF-R2) and trombomodulin (TM) have been investigated in serum by enzyme immunoassay using special kits (BCM Diagnostics, USA). Other endothelial dysfunction markers as von Willebrand factor (vWf) was determined in blood plasma by immunoturbidimetry (Siemens, Germany), plasminogen (PLG) was investigated due to extended coagulation. In children with CVH, regardless of etiology, the concentration of VEGF-A was significantly lower, and sVEGF-R2, sVEGF-R1 and TM was higher than in children without liver disease (p <0.001, p <0.05, p <0.01, p <0.001, respectively). The concentration of TM and the level of PLG activity in patients with CHC were slightly higher than in CHB. Decreased level of VEGF-A and increased expression of its soluble receptors indicate enhanced inhibition of angiogenesis in CVH, which may indicate the pathogenetic role of this phenomenon in the development of liver damage in CHC.
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Shang, Mei, and Haochen Geng. "A study on carbon emission calculation of residential buildings based on whole life cycle evaluation." E3S Web of Conferences 261 (2021): 04013. http://dx.doi.org/10.1051/e3sconf/202126104013.

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The whole life cycle carbon emission of buildings was calculated in this paper. Based on the whole life cycle evaluation theory, a carbon emission calculation model was established by using a single urban building as an example. The whole life cycle building of carbon emission calculation includes five stages: planning and design, building materials preparation, construction, operational maintenance, as well as dismantlement. It provides a reference for standardizing the calculation process of building carbon emissions by analyzed the carbon emissions and composition characteristics of each stage of the life cycle of the case house. The calculation results demonstrate that the carbon emission during the operational maintenance and building materials preparation stages in the whole life cycle of the building account for 78.05% and 20.59% respectively. These are the two stages with the greatest emission reduction potential.
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