Academic literature on the topic 'Sigme proteins'

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Journal articles on the topic "Sigme proteins"

1

Raman, Sahadevan, Xiaoling Puyang, Tan-Yun Cheng, David C. Young, D. Branch Moody, and Robert N. Husson. "Mycobacterium tuberculosis SigM Positively Regulates Esx Secreted Protein and Nonribosomal Peptide Synthetase Genes and Down Regulates Virulence-Associated Surface Lipid Synthesis." Journal of Bacteriology 188, no. 24 (2006): 8460–68. http://dx.doi.org/10.1128/jb.01212-06.

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ABSTRACT The Mycobacterium tuberculosis genome encodes 12 alternative sigma factors, several of which regulate stress responses and are required for virulence in animal models of acute infection. In this work we investigated M. tuberculosis SigM, a member of the extracytoplasmic function subfamily of alternative sigma factors. This sigma factor is expressed at low levels in vitro and does not appear to function in stress response regulation. Instead, SigM positively regulates genes required for the synthesis of surface or secreted molecules. Among these are genes encoding two pairs of Esx secr
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2

Nakunst, Diana, Christof Larisch, Andrea T. Hüser, Andreas Tauch, Alfred Pühler, and Jörn Kalinowski. "The Extracytoplasmic Function-Type Sigma Factor SigM of Corynebacterium glutamicum ATCC 13032 Is Involved in Transcription of Disulfide Stress-Related Genes." Journal of Bacteriology 189, no. 13 (2007): 4696–707. http://dx.doi.org/10.1128/jb.00382-07.

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ABSTRACT The gene for the extracytoplasmic function (ECF) sigma factor SigM was deleted from the chromosome of the gram-positive soil bacterium Corynebacterium glutamicum to elucidate the role of the SigM protein in the regulation of gene expression. Comparative DNA microarray hybridizations of the C. glutamicum wild type and sigM-deficient mutant C. glutamicum DN1 revealed 23 genes with enhanced expression in the sigM-proficient strain, encoding functions in the assembly of iron-sulfur clusters (suf operon), thioredoxin reductase (trxB), thioredoxins (trxC, trxB1), chaperones (groES, groEL, c
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3

Fernandes, Norvin D., Qi-long Wu, Dequan Kong, Xiaoling Puyang, Sumeet Garg, and Robert N. Husson. "A Mycobacterial Extracytoplasmic Sigma Factor Involved in Survival following Heat Shock and Oxidative Stress." Journal of Bacteriology 181, no. 14 (1999): 4266–74. http://dx.doi.org/10.1128/jb.181.14.4266-4274.1999.

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ABSTRACT Extracytoplasmic function (ECF) sigma factors are a heterogeneous group of alternative sigma factors that regulate gene expression in response to a variety of conditions, including stress. We previously characterized a mycobacterial ECF sigma factor, SigE, that contributes to survival following several distinct stresses. A gene encoding a closely related sigma factor, sigH, was cloned fromMycobacterium tuberculosis and Mycobacterium smegmatis. A single copy of this gene is present in these and other fast- and slow-growing mycobacteria, including M. fortuitum and M. avium. While the M.
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Singh, Rakesh Kumar, Lav Kumar Jaiswal, Tanmayee Nayak, et al. "Expression, Purification, and In Silico Characterization of Mycobacterium smegmatis Alternative Sigma Factor SigB." Disease Markers 2022 (May 20, 2022): 1–11. http://dx.doi.org/10.1155/2022/7475704.

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Sigma factor B (SigB), an alternative sigma factor (ASF), is very similar to primary sigma factor SigA (σ70) but dispensable for growth in both Mycobacterium smegmatis (Msmeg) and Mycobacterium tuberculosis (Mtb). It is involved in general stress responses including heat, oxidative, surface, starvation stress, and macrophage infections. Despite having an extremely short half-life, SigB tends to operate downstream of at least three stress-responsive extra cytoplasmic function (ECF) sigma factors (SigH, SigE, SigL) and SigF involved in multiple signaling pathways. There is very little informatio
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5

White, Mark J., Hongjun He, Renee M. Penoske, Sally S. Twining, and Thomas C. Zahrt. "PepD Participates in the Mycobacterial Stress Response Mediated through MprAB and SigE." Journal of Bacteriology 192, no. 6 (2010): 1498–510. http://dx.doi.org/10.1128/jb.01167-09.

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ABSTRACT Currently, one-third of the world's population is believed to be latently infected with Mycobacterium tuberculosis. The mechanisms by which M. tuberculosis establishes latent infection remain largely undefined. mprAB encodes a two-component signal transduction system required by M. tuberculosis for aspects of persistent infection. MprAB regulates a large and diverse group of genetic determinants in response to membrane stress, including the extracytoplasmic function (ECF) sigma factor sigE and the HtrA-like serine protease pepD. Recent studies have demonstrated that PepD functions as
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6

Kim, Eun Sook, Ju Yeon Song, Dae Wi Kim, Keith F. Chater, and Kye Joon Lee. "A Possible Extended Family of Regulators of Sigma Factor Activity in Streptomyces coelicolor." Journal of Bacteriology 190, no. 22 (2008): 7559–66. http://dx.doi.org/10.1128/jb.00470-08.

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ABSTRACT SCO4677 is one of a large number of similar genes in Streptomyces coelicolor that encode proteins with an HATPase_c domain resembling that of anti-sigma factors such as SpoIIAB of Bacillus subtilis. However, SCO4677 is not located close to genes likely to encode a cognate sigma or anti-anti-sigma factor. SCO4677 was found to regulate antibiotic production and morphological differentiation, both of which were significantly enhanced by the deletion of SCO4677. Through protein-protein interaction screening of candidate sigma factor partners using the yeast two-hybrid system, SCO4677 prot
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7

Kazmierczak, Mark J., Martin Wiedmann, and Kathryn J. Boor. "Alternative Sigma Factors and Their Roles in Bacterial Virulence." Microbiology and Molecular Biology Reviews 69, no. 4 (2005): 527–43. http://dx.doi.org/10.1128/mmbr.69.4.527-543.2005.

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SUMMARY Sigma factors provide promoter recognition specificity to RNA polymerase holoenzyme, contribute to DNA strand separation, and then dissociate from the core enzyme following transcription initiation. As the regulon of a single sigma factor can be composed of hundreds of genes, sigma factors can provide effective mechanisms for simultaneously regulating expression of large numbers of prokaryotic genes. One newly emerging field is identification of the specific roles of alternative sigma factors in regulating expression of virulence genes and virulence-associated genes in bacterial pathog
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8

S Thompson, L., and E. J Harry. "Alternative sigma factors: the master regulators." Microbiology Australia 27, no. 3 (2006): 118. http://dx.doi.org/10.1071/ma06118.

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When a bacterial cell encounters a change in environmental conditions, it responds by producing a different complement of cellular proteins. Which proteins are produced and maintained is regulated in a number of ways, including regulation of gene transcription, stabilising or degrading mRNA transcripts, post translational modifications and targeted degradation of proteins.
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9

Yang, Fumeng, Wenjun Wang, Qian Liu, et al. "The application of Six Sigma to perform quality analyses of plasma proteins." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 57, no. 2 (2019): 121–27. http://dx.doi.org/10.1177/0004563219892023.

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Background The Six Sigma theory is an important tool for laboratory quality management. It has been widely used in clinical chemistry, haematology and other disciplines. The aim of our study was to evaluate the analytical performance of plasma proteins by application of Sigma metric and to compare the differences among three different allowable total errors in evaluating the analytical performance of plasma proteins. Methods Three different allowable total error values were used as quality goals. Data from an external quality assessment were used as bias, and the cumulative coefficient of vari
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10

Mortillaro, N. A., and A. E. Taylor. "Microvascular permeability to endogenous plasma proteins in the jejunum." American Journal of Physiology-Heart and Circulatory Physiology 258, no. 6 (1990): H1650—H1654. http://dx.doi.org/10.1152/ajpheart.1990.258.6.h1650.

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Steady-state lymph flow and lymph (CL) and plasma (CP) protein concentrations were measured at venous outflow pressures of 0, 10, 20, and 30 mmHg in an autoperfused segment of cat jejunum. In addition to determining total protein concentrations in lymph and plasma, polyacrylamide gradient gel electrophoresis was used to determine lymph and plasma protein concentrations of albumin and nine other plasma proteins. The osmotic reflection coefficient (sigma d) for total proteins, albumin, and each of the nine protein fractions was estimated using CL/CP at a capillary filtration rate independent sta
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