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Dissertations / Theses on the topic 'Signal recognition particle (SRP)'

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Published: 7 June 2025

Last updated: 16 July 2025

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1

Faoro, Camilla. "The Signal Recognition Particle: noncanonical functions and drug discovery." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20168.

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The Signal Recognition Particle (SRP) is an essential ribonucleoprotein complex responsible for co-translational delivery of membrane and secretory proteins to the plasma membrane in prokaryotes and to the endoplasmic reticulum in eukaryotes. In Eubacteria, SRP consists of the GTPase Ffh and the small 4.5S RNA; in eukaryotes, the system is more complex and SRP comprises six proteins (the heterodimer SRP 9/14, SRP 19, SRP 54, and the heterodimer SRP 68/72) along with a large RNA moiety, the 7SL RNA. SRP has been reported to be involved in many cellular processes outside the SRP-targeting cycle.

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2

Birse, Darcy E. A. "Étude structurale du domaine alu de la particule de reconnaissance du signal (SRP)." Université Joseph Fourier (Grenoble ; 1971-2015), 1998. http://www.theses.fr/1998GRE10088.

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Le sujet de cette these est l'etude structurale du domaine alu de la particule de reconnaissance du signal (srp). Le projet a ete la cristallisation et la determination de la structure du domaine de liaison de l'arn au niveau de l'heterodimere srp9/14, suivi par la caracterisation des interactions proteines-arn, en particulier, l'identification des interactions specifiques entre l'heterodimere srp9/14 et l'arn srp humain qui, ensemble, constituent le domaine alu du srp. L'heterodimere srp9/14 de souris a ete cristallise. Pour resoudre la structure mir, des cristaux natifs et de derives ont ete

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3

Janda, Claudia Yvonne. "Biochemical and structural studies of signal sequence recognition by SRP." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611869.

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4

Patel, Sarju. "The 54kDa sub unit of the signal recognition particle." Thesis, St George's, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339121.

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5

Leung, Eileen. "Quality control in the biogenesis of the signal recognition particle." Thesis, University of Newcastle upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506530.

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6

Hutin, Claire. "Caractérisation de la voie d'adressage aux thylacoi͏̈des : cpSRP (chloroplastic Signal Recognition Particle)." Paris 11, 2002. http://www.theses.fr/2002PA112250.

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Nous avons étudié le rôle in vivo des sous-unités du complexe cpSRP, qui est responsable de l'adressage intrachloroplastique des antennes photosynthétiques aux thylakoi͏̈des. Des analyses conduites in vitro sur la stoechiométrie du complexe étaient très controversées et la mise en évidence par la technique du double hybride de la dimérisation de cpSRP43 au sein du complexe de transit, tend à démontrer qu'in vivo, le complexe serait capable de prendre en charge deux molécules d'antennes photosynthétiques en association avec deux molécules de cpSRP54. L'analyse du double mutant ffc/chaos (cpSRP5

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7

Maity, Tuhin Subhra Weeks Kevin. "Temporal order of interaction directs native assembly of the mammalian signal recognition particle." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,778.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Dec. 18, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Chemistry." Discipline: Chemistry; Department/School: Chemistry.

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8

Jovine, Luca Vincenzo Luigi. "Structural studies of the U1A - 3'UTR complex and of signal recognition particle." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624591.

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9

Menichelli, Elena. "Structural and biochemical studies of the S domain of the human signal recognition particle." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613670.

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10

Muhammad, Asim, and Akbar Ali. "Source Localization and Speech Enhancement for Speech Recognition for Real time Environment." Thesis, Blekinge Tekniska Högskola, Sektionen för ingenjörsvetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-4130.

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Popularity of speech communication is rapidly increasing in various contexts such as conferencing systems, mobile/fixed electronic devices and laptops thus leading to a heightened demand for new services and improved speech quality. Dictaphones used for dictations usually have one microphone. Single microphone does not give enough degree of freedom to allow estimation of location of the source. Microphone array makes use of multiple microphones for spatial filtering suppressing the background noise. This report aims for speech enhancement utilizing the benefits inherited with microphone arrays

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11

Flores, Janine Kate. "Characterisation of the human signal recognition particle protein component, SRP68/72, and its role in co-translational translocation." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18698.

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One of the most fundamental processes within the cell is ensuring that translated proteins are compartmentalised to their appropriate cellular location. To ensure that this process occurs efficiently, the cell employs several pathways to transport each protein to their designated area. There are two main systems for protein transport, which occur during (co-translational) or after (post-translational) the process of translation. These protein transport systems are well characterised; however, the complexes that mediate these pathways are not well understood. In this project, we are interested

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12

Colberg, Clara Ottilie Freifrau Loeffelholz von. "Etudes au microscope électronique du transport des protéines durant la traduction chez E. Coli, et de la terminaison de la traduction chez l'homme." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENV038/document.

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La particule de reconnaissance du signal (signal recognition particle-SRP) et son récepteur (FtsY chez Escherichia coli) médiatise le processus simultané de traduction-ciblage de la protéine en dirigeant le complexe ribosome-nascent chain (RNCs) vers la membrane de destination. La reconnaissance par la SRP d'une charge RNC à transporter dépend de la présence de la partie N-terminale. L'assemblage de Ftsy au complexe RNC-PRS entraine plusieurs changements de configuration de SRP et de FtsY durant le cycle de direction. D'abord un stade « précoce » sans GTP est adopté. Celui-ci est stabilisé par

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13

Kuglstatter, Andreas. "Structural and biochemical studies of S-domain of signal recognition particle and splicing factor complexes SF3a and SF3b." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620710.

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14

Song, Weiqun. "Regulation of the Transfer of the Ribosome-Nascent Chain Complex from the Signal Recognition Particle to the Translocation Channel: a Thesis." eScholarship@UMMS, 2006. http://escholarship.umassmed.edu/gsbs_diss/301.

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Translocation across or integration into the rough endoplasmic reticulum (RER) membrane is the first step in the intracelluar sorting of proteins in eukaryotic cells. This process is initiated when a signal sequence in the nascent protein chain emerges from the ribosome and is recognized by the signal recognition particle (SRP). The resulting SRP-ribosome-nascent chain-complex (SRP-RNC) is targeted to the RER membrane through the concerted action of the SRP and the SRP receptor (SR). The nascent chain is then displaced from SRP and transferred to the translocon, a proteinaceous channel compose

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15

Song, Weiqun. "Regulation of the Transfer of the Ribosome-Nascent Chain Complex from the Signal Recognition Particle to the Translocation Channel: a Thesis." eScholarship@UMMS, 2000. https://escholarship.umassmed.edu/gsbs_diss/301.

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Translocation across or integration into the rough endoplasmic reticulum (RER) membrane is the first step in the intracelluar sorting of proteins in eukaryotic cells. This process is initiated when a signal sequence in the nascent protein chain emerges from the ribosome and is recognized by the signal recognition particle (SRP). The resulting SRP-ribosome-nascent chain-complex (SRP-RNC) is targeted to the RER membrane through the concerted action of the SRP and the SRP receptor (SR). The nascent chain is then displaced from SRP and transferred to the translocon, a proteinaceous channel compose

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16

Sauerbrei, Beate [Verfasser], Franz [Gutachter] Narberhaus, and Danja [Gutachter] Schünemann. "Lon-dependent proteolysis of Ffh, the protein component of the signal recognition particle in Escherichia coli / Beate Sauerbrei ; Gutachter: Franz Narberhaus, Danja Schünemann ; Fakultät für Biologie und Biotechnologie." Bochum : Ruhr-Universität Bochum, 2020. http://d-nb.info/1216332983/34.

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17

Jiang, Ying. "Transfer of the Ribosome-Nascent Chain Complex to the Translocon in Cotranslational Translocation: A Thesis." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/332.

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Cotranslational translocation is initiated by targeting of a ribosome-bound nascent polypeptide chain (RNC) to the endoplasmic reticulum (ER) membrane. The targeting reaction is coordinated by the signal recognition particle (SRP) through its interaction with the RNC and the membrane-bound SRP receptor (SR). A vacant translocon is a prerequisite for the subsequent nascent chain release from SRP-SR-RNC complex. It has been proposed that the protease-accessible cytosolic domains of the Sec61p complex play an important role in posttargeting steps by providing the binding site for the ribosome or

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18

Raine, Amanda. "Ribosome Associated Factors Recruited for Protein Export and Folding." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4839.

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19

Srinivasamurthy, Ajay. "A Data-driven bayesian approach to automatic rhythm analysis of indian art music." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/398986.

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Las colecciones de música son cada vez mayores y más variadas, haciendo necesarias nuevas fórmulas para su organización automática. El análisis automático del ritmo tiene como fin la extracción de información rítmica de grabaciones musicales y es una de las principales áreas de investigación en la disciplina de recuperación de la información musical (MIR por sus siglas en inglés). La dimensión rítmica de la música es específica a una cultura y por tanto su análisis requiere métodos que incluyan el contexto cultural. Las complejidades rítmicas de la música clásica de la India, una de las may

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20

Draycheva, Albena. "Interaction of the SecYEG translocon with the SRP receptor and the ribosome." Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0022-5FD2-D.

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21

Cleverley, Robert Matthew. "The interaction of signal sequences with the signal recognition particle." 2002. https://scholarworks.umass.edu/dissertations/AAI3068547.

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The signal recognition particle (SRP) is an RNA-protein complex that directs proteins containing an N-terminal signal sequence into the secretory pathway. For high fidelity in the selection of substrates for secretion, the SRP must recognize the features of signal sequences that uniquely distinguish them from other segments of proteins. The recognition of signal sequences by SRP is therefore almost certain to involve novel modes of protein-peptide interaction. Based on crosslinking data and the crystal structure of the SRP protein subunit Ffh, it is widely assumed, though unsubstantiated by ex

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22

Ariosa, Aileen Renia. "Mechanisms of Substrate Selection by the Signal Recognition Particle." Thesis, 2014. https://thesis.library.caltech.edu/8441/1/thesis_aileen.pdf.

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The signal recognition particle (SRP) targets membrane and secretory proteins to their correct cellular destination with remarkably high fidelity. Previous studies have shown that multiple checkpoints exist within this targeting pathway that allows ‘correct cargo’ to be quickly and efficiently targeted and for ‘incorrect cargo’ to be promptly rejected. In this work, we delved further into understanding the mechanisms of how substrates are selected or discarded by the SRP. First, we discovered the role of the SRP fingerloop and how it activates the SRP and SRP receptor (SR) GTPases to target an

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23

Jaru-Ampornpan, Peera. "Post-Translational Membrane Protein Targeting by the Chloroplast Signal Recognition Particle." Thesis, 2011. https://thesis.library.caltech.edu/6429/9/Thesis_Peera.pdf.

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Post-translational transport of membrane proteins poses enormous challenges to the cells. The transport factors must accurately select and deliver the cargos to the appropriate target membranes. In addition, they have to provide chaperone for their hydrophobic cargos. To understand capacity and limitation of a post-translational transport factor, we studied one of the most efficient membrane protein transport pathways, the delivery of light-harvesting chlorophyll-binding (LHC) proteins to the thylakoid membrane. This targeting reaction is mediated by the chloroplast Signal Recognition Part

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24

LEENA, PHILOMINATHAN SAGAYA THERESA, and 黎娜. "Structures and binding properties of various domains derived from the 43kDa subunit of the Chloroplast Signal Recognition Particle." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/87274169442165345470.

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博士<br>國立清華大學<br>化學系<br>91<br>The signal recognition particle (SRP) play a vital role in the co-translational targeting of proteins across the membrane. The SRP present in chloroplast exist in two pools, one containing the 54 kDa domain (cpSRP54) and the other containing a 43 kDa domain (cpSRP43). The cpSRP43 is involved in the targeting of the light harvesting chlorophyll-binding protein (LHCP) to the thylakoids. cpSRP43 as such contains 308 amino acids and hence it is technically challenging to solve the three dimensional structure by NMR. Domain structure of cpSRP43 reveals that it conta

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25

Hwang-Fu, Yu-Hsien. "Dynamic Regulations of Co-translational Protein Targeting by the Signal Recognition Particle Receptor in E. coli and Human." Thesis, 2019. https://thesis.library.caltech.edu/11309/9/YuHsien_HwangFu_2019_thesis_final.pdf.

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<p>The Signal Recognition Particle (SRP) and its receptor (SR) co-translationally deliver the majority of secretory and membrane proteins to their membrane destinations. SRP recognizes and binds to the cargo, and SR recruits the transit complex to the target membrane. Precise timing and coordination are encoded into the interactions between SRP and SR in response to the cargo and environment to enable efficient and accurate targeting. This dissertation explores the regulation mechanisms of SRP membrane recruitment by SR in both bacteria and eukaryotes.</p> <p>The bacterial SR is a periphera

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26

Chang, An-Ni, and 張安妮. "Determination of the solution structure of Chrmo2 domain of the chloroplast signal recognition particle using multi-dimensional NMR spectroscopy." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/65357759930250636454.

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碩士<br>國立清華大學<br>化學系<br>90<br>The signal recognition particle (SRP) is a ubiquitous system for the targeting of membrane and secreted proteins. The chloroplast SRP (cpSRP) is unique among SRPs in that it possesses no RNA and is functional in post-translational as well as co-translational targeting. cpSRP is present within two pools in the chloroplast: a co-translationally active SRP54 homologue (cpSRP54) and a post translationally active cpSRP, which is a complex of cpSRP54 and the novel SRP component, cpSRP43. The presence or absence of cpSRP43 seems to determine the targeting activity of cpSR

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27

Lee, Sejeong. "Dynamic interactions during ribosome targeting to the membrane." Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0022-5FD8-1.

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28

Nyathi, Yvonne, and M. R. Pool. "Analysis of the interplay of protein biogenesis factors at the ribosome exit site reveals new role for NAC." 2015. http://hdl.handle.net/10454/17895.

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Yes<br>The ribosome exit site is a focal point for the interaction of protein-biogenesis factors that guide the fate of nascent polypeptides. These factors include chaperones such as NAC, N-terminal-modifying enzymes like Methionine aminopeptidase (MetAP), and the signal recognition particle (SRP), which targets secretory and membrane proteins to the ER. These factors potentially compete with one another in the short time-window when the nascent chain first emerges at the exit site, suggesting a need for regulation. Here, we show that MetAP contacts the ribosome at the universal adaptor site

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