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Dissertations / Theses on the topic 'Signal regulatory proteins'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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1

Lonergan, Natalie Elaine. "Characterizing the cargo binding and regulatory function of the tail domain in Ncd motor protein." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/35511.

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Non-claret disjunctional (Ncd) is a kinesin-14 microtubule motor protein involved in the assembly and stability of meiotic and mitotic spindles in Drosophila oocytes and early embryos, respectively. Ncd functions by cross-linking microtubules through the tail and motor domains. It was originally believed that the role of the Ncd tail domain was to only statically bind microtubules. However, the Ncd tail domain has recently been shown to have properties that stabilize and bundle microtubules, and contribute to the overall motility of the Ncd protein. Continued characterization of the Ncd tail d

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2

Vernon-Wilson, Elizabeth. "Molecular analysis of SIRP/CD47 interaction in rheumatoid arthritis." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342242.

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3

Rohatgi, Rasika. "Autophagy-Independent Role for Beclin 1 in the Regulation of Growth Factor Receptor Signaling: A Dissertation." eScholarship@UMMS, 2015. http://escholarship.umassmed.edu/gsbs_diss/873.

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Beclin 1 is a haplo-insufficient tumor suppressor that is decreased in many human tumors. The function of Beclin 1 in cancer has been attributed primarily to its role in the degradative process of autophagy. However, the role of autophagy itself in tumorigenesis is context-dependent and can be both preventive and promoting. Due to its dual function in cancer a better understanding of this process is necessary to develop potential novel cancer therapies. To gain insight into the role of autophagy in breast carcinoma, I analyzed the autophagydependency of different subtypes of breast cancer. My

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4

Lee, Connie Wing-Ching. "Notch-1 and IGF-1 as Survivin Regulatory Pathways in Cancer: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/377.

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The 21st century brought about a dramatic increase in knowledge about genetic and molecular profiles of cancer. This information has validated the complexity of tumor cells and increased awareness of “nodal proteins”, but has yet to advance the development of rational targeted cancer therapeutics. Nodal proteins are critical cellular proteins that collect biological inputs and distribute the information across diverse biological processes. Survivin acts as a nodal protein by interfacing the multiple signals involved in mitosis and apoptosis and functionally integrate proliferation, cell death,

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5

Jain, Nitya. "Multifaceted Regulation of Peripheral T Cell Tolerance and Autoimmunity by FOXP3+ T Regulatory Cells: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/416.

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Adaptive immunity requires T cell responses to foreign pathogens to be counterbalanced with the need to limit collateral destruction of the host’s own tissues. Further, the presence of a substantial pool of lymphocytes capable of recognizing selfantigen in the periphery poses a threat to the maintenance of peripheral tolerance and prevention of autoimmunity. Regulatory T cells (Treg) that can suppress potentially self-reactive T cells are critical regulators of peripheral tolerance as well as initiation of immune responses. Treg cells employ several context-dependent mechanisms to establish re

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6

Scofield, Michael D. "Elucidating the Transcriptional Network Underlying Expression of a Neuronal Nicotinic Receptor Gene: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/497.

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Neuronal nicotinic acetylcholine receptors (nAChRs) are involved in a plethora of fundamental biological processes ranging from muscle contraction to the formation of memories. The studies described in this work focus on the transcriptional regulation of the CHRNB4 gene, which encodes the ß4 subunit of neuronal nAChRs. We previously identified a regulatory sequence (5´– CCACCCCT –3´), or “CA box”, critical for CHRNB4 promoter activity in vitro. Here I report transcription factor interaction at the CA box along with an in vivo analysis of CA box transcriptional activity. My data indicate that S

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7

Scofield, Michael D. "Elucidating the Transcriptional Network Underlying Expression of a Neuronal Nicotinic Receptor Gene: A Dissertation." eScholarship@UMMS, 2009. http://escholarship.umassmed.edu/gsbs_diss/497.

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Neuronal nicotinic acetylcholine receptors (nAChRs) are involved in a plethora of fundamental biological processes ranging from muscle contraction to the formation of memories. The studies described in this work focus on the transcriptional regulation of the CHRNB4 gene, which encodes the ß4 subunit of neuronal nAChRs. We previously identified a regulatory sequence (5´– CCACCCCT –3´), or “CA box”, critical for CHRNB4 promoter activity in vitro. Here I report transcription factor interaction at the CA box along with an in vivo analysis of CA box transcriptional activity. My data indicate that S

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8

Rodríguez, Solovey Leisa Natacha. "IDENTIFICATION OF TARGETS AND AUXILIARY PROTEINS OF PYR/PYL/RCAR ABA RECEPTORS: PROTEIN PHOSPHATASES TYPE 2C (PP2Cs) AND C2-DOMAIN ABA-RELATED PROTEINS (CARs)." Doctoral thesis, Universitat Politècnica de València, 2015. http://hdl.handle.net/10251/58862.

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[EN] ABSTRACT Abscisic acid (ABA) signaling plays a critical role in regulating root growth and root system architecture. ABA-mediated growth promotion and root tropic response under water stress are key responses for plant survival under limiting water conditions. In this work, we have explored the role of Arabidopsis (Arabidopsis thaliana) PYR/PYL/RCAR receptors (PYRABACTIN RESISTANCE1 (PYR1)/PYR1 LIKE (PYL)/REGULATORY COMPONENTS OF ABA RECEPTORS) for root ABA signaling. As a result, we discovered that PYL8 plays a nonredundant role for the regulation of root ABA sensitivity. Unexpectedly,

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9

Bird, Christopher Allen. "Characterisation of the signal regulatory protein family of myeloid receptors." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531956.

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10

Song, Alexander. "Signal regulatory protein alpha expression and function in human vascular endothelium." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12227.

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Thesis (M.A.)--Boston University<br>The human immune system is capable of detecting and removing foreign invaders such as viruses, microorganisms, and other harmful materials. A key component of this immune response is leukocyte recruitment—a process, in which leukocytes travel from the bloodstream to the site of injury or infection. SIRPα, a protein mainly known to be expressed in myeloid leukocytes, has been shown to contribute to this process by regulating transendothelial migration (TEM)—leukocyte passage through the vascular endothelium. Interestingly, a recent study has detected low leve

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11

Campbell, Pearl. "Pou5f1 Post-translational Modifications Modulate Gene Expression and Cell Fate." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23607.

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Embryonic stem cells (ESCs) are characterized by their unlimited capacity for self-renewal and the ability to contribute to every lineage of the developing embryo. The promoters of developmentally regulated loci within these cells are marked by coincident epigenetic modifications of gene activation and repression, termed bivalent domains. Trithorax group (TrxG) and Polycomb Group (PcG) proteins respectively place these epigenetic marks on chromatin and extensively colocalize with Oct4 in ESCs. Although it appears that these cells are poised and ready for differentiation, the switch that permi

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12

Cardoso, Alisson Campos 1983. "FAK interage com MEF2 e ativa região intronica regulatoria do fosfolamban em resposta ao estimulo mecanico." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310213.

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Orientador: Kleber Gomes Franchini<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-11T19:13:47Z (GMT). No. of bitstreams: 1 Cardoso_AlissonCampos_M.pdf: 1504948 bytes, checksum: 1996e50c40d74c7a53a5058831fb03ab (MD5) Previous issue date: 2008<br>Resumo: Estudos anteriores demonstraram que em miócitos cardíacos submetidos a estímulos mecânicos ocorre pronta fosforilação e ativação da FAK. Resultados de estudos recentes, realizados em corações de ratos indicaram que em resposta a estímulos mecânicos, a FAK, alé

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13

Spannagel, Ralf. "Klonierung und Charakterisierung von Signal Regulatory Protein beta in primären Makrophagen der Maus." [S.l. : s.n.], 2004. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11380362.

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14

Slavny, Peter. "Role of the PAS2 domain of the NifL regulatory protein in redox signal transduction." Thesis, University of East Anglia, 2010. https://ueaeprints.uea.ac.uk/20504/.

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15

Wojciech, Stéfanie. "The orphan 7TM protein GPR50 as a novel regulator of TGFβ signal transduction". Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T084/document.

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La protéine GPR50, qui fait partie de la famille des récepteurs de la mélatonine, est classée, avec une centaine d’autres protéines à sept domaines transmembranaires (7TM), dans la catégorie des récepteurs couplés aux protéines G hétérotrimériques (RCPG) orphelins, c’est-à-dire pour lesquels aucun ligand n’a pu être identifié. De plus en plus d’études montrent que les 7TM peuvent avoir des fonctions indépendantes d’un ligand. C’est le cas de GPR50 qui inhibe les fonctions du récepteur de la mélatonine MT1 en interagissant directement avec lui. Nous avons cherché à identifier d’autres partenair

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16

Swaroop, Navin V. "Nuclear factor-[kappa] B signal transduction development of a novel regulatory strategy /." Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1598.

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Thesis (M.S.)--West Virginia University, 2000.<br>Title from document title page. Document formatted into pages; contains ix, 70 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 63-68).

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17

Zhu, Weidong, and 朱伟东. "APPL1 and APPL2: a pair of adaptor proteins as "yin-and-yang" regulators of insulin signaling in skeletalmuscle." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B45980470.

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18

Evans, John W. III. "Itk is a Dual Action Regulator of Immunoreceptor Signaling in the Innate and Adaptive Immune System: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/688.

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The cells and molecules that comprise the immune system are essential for mounting an effective response against microbes. A successful immune response limits pathology within the host while simultaneously eliminating the pathogen. The key to this delicate balance is the correct recognition of the pathogen and the appropriate response of immune cells. Cellular activation originates through receptors that relay information about the state of the microenvironment to different compartments within the cell. The rapid relay of information is called signal transduction and employs a network of signa

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Evans, John W. III. "Itk is a Dual Action Regulator of Immunoreceptor Signaling in the Innate and Adaptive Immune System: A Dissertation." eScholarship@UMMS, 2007. http://escholarship.umassmed.edu/gsbs_diss/688.

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The cells and molecules that comprise the immune system are essential for mounting an effective response against microbes. A successful immune response limits pathology within the host while simultaneously eliminating the pathogen. The key to this delicate balance is the correct recognition of the pathogen and the appropriate response of immune cells. Cellular activation originates through receptors that relay information about the state of the microenvironment to different compartments within the cell. The rapid relay of information is called signal transduction and employs a network of signa

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20

Ganesan, Sundar. "Local protein turnover as a regulatory mechanism of growth and collapse of neuronal growth cones." Doctoral thesis, [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976327376.

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21

Lo, Kin Yip. "Regulators of neurotrophin-mediated Trk signaling : SLAM-associated protein (SAP) and cyclin-dependent kinase 5 (Cdk5) /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?BICH%202005%20LO.

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22

Strainic, Michael George Jr. "THE ABSENCE OF C3AR AND C5AR SIGNAL TRANSDUCTION PROMOTES T REGULATORY CELL DIFFERENTIATION AND REGULATES IMMUNOLOGIC TOLERANCE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1363707372.

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23

Parry, Joanne Rachel. "Studies into the role of members of the mitogen-activated protein kinase family and their upstream regulatory pathways in interleukin-1 signal transduction." Thesis, University of Sheffield, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339934.

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24

Sezaki, Takuhito. "Roles of Dlg5, a Crohn's disease associated protein, as a regulator of TGF-β signals and epithelial-to-mesenchymal transition". Kyoto University, 2012. http://hdl.handle.net/2433/165040.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第17236号<br>農博第1962号<br>新制||農||1006(附属図書館)<br>学位論文||H24||N4719(農学部図書室)<br>29982<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授植田和光, 教授阪井康能, 教授植田充美<br>学位規則第4条第1項該当

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Sammons, Wendy L. "Generation and characterization of an attenuated mutant in a response-regulator gene of Francisella tularensis live vaccine strain (LVS)." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002268.

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26

Beka, Sylvia Enobong. "The genomics of Type 1 Diabetes susceptibility regions and effect of regulatory SNPs." Thesis, University of Hertfordshire, 2016. http://hdl.handle.net/2299/17200.

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Human complex diseases, like Diabetes and Cancer, affect many people worldwide today. Despite existing knowledge, many of these diseases are still not preventable. Complex diseases are known to be caused by a combination of genetic factors, as well as environmental and life style factors. The scope of this investigation covered the genomics of Type 1 Diabetes (T1D). There are 49 human genomic regions that are known to carry markers (disease-associated single nucleotide mutations) for T1D, and these were extensively studied in this research. The aim was to find out in how far this disease may b

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27

Bertheau, Lucie. "Caractérisation d'un phosphorelais multiple de type histidine-aspartate dans la transduction du signal de la contrainte osmotique chez le peuplier : mécanismes de régulation du fonctionnement d'un régulateur de réponse de type-B à l'échelle moléculaire." Thesis, Orléans, 2013. http://www.theses.fr/2013ORLE2076/document.

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Les relais de phosphorylation de type histidine/aspartate constituent des voies de signalisation impliquées dans la perception et la transduction des signaux jusqu’à la mise en place de réponses spécifiques. Ils mettent en jeu un récepteur ou Histidine aspartate Kinase (HK), des protéines navettes en charge de la transmission du phosphate (HPt) et des Régulateurs de Réponse (RR). L’implication d’un tel système dans la transduction du signal de la contrainte osmotique est avérée chez la levure et fortement suspectée chez Arabidopsis. Ce travail de thèse visait d’une part à caractériser l’implic

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28

Barros, Diana Manuela Pinto. "Classification and structure-based inference of transcriptional regulatory proteins." Master's thesis, 2016. http://hdl.handle.net/1822/49099.

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Dissertação de mestrado em Bioinformática<br>Transcription factors (TFs) are proteins that mediate the cellular response to the changes of the surrounding environment. Studying their functional domains and protein structure is fundamental in order to gain insight of the way they are triggered and how they shape genetic transcription. The current work aimed for classifying both TFs and functional domains, understanding which features can be related to the different functions of the TFs. By using UniProtJAPI, a JAVA library that allows remote access to UniProt, the information of 200 Esche

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Neppl, Ronald Lee. "Myosin phosphatase and myocardin regulatory pathways modulating smooth muscle contractility and differentiation /." 2008. http://proquest.umi.com/pqdweb?did=1805427641&sid=2&Fmt=2&clientId=3507&RQT=309&VName=PQD.

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30

Batarseh, Ghada. "Tegdma induction of apoptotic proteins in pulp fibroblasts." Thesis, 2011. http://hdl.handle.net/1805/2709.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Monomers like triethylene glycol dimethacrylate (TEGDMA) leach from dental composites and adhesives due to incomplete polymerization or polymer degradation. The release of these monomers causes a variety of reactions that can lead to cell death. This death can be either necrotic, which is characterized mainly by inflammation and injury to the surrounding tissues, or apoptotic, which elicits little inflammatory responses, if any at all. TEGDMA-induced apoptosis in human pulp has been reported recently. However, the molecular mechanism

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31

Traer, Elie. "Regulation of cytochrome C release in UV-induced apoptosis." 2006. http://edissertations.library.swmed.edu/pdf/TraerE051606/TraerElie.pdf.

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32

Dey, Souvik. "Transcriptional regulation of ATF4 is critical for controlling the Integrated Stress Response during eIF2 phosphorylation." Thesis, 2012. http://hdl.handle.net/1805/3041.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>In response to different environmental stresses, phosphorylation of eIF2 (eIF2P) represses global translation coincident with preferential translation of ATF4. ATF4 is a transcriptional activator of the integrated stress response, a program of gene expression involved in metabolism, nutrient uptake, anti-oxidation, and the activation of additional transcription factors, such as CHOP/GADD153, that can induce apoptosis. Although eIF2P elicits translational control in response to many different stress arrangements, there are selecte

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33

Gaikwad, Sadanand [Verfasser]. "Functional analysis of microglial signal regulatory protein β [beta] 1 (SIRPβ1) [SIRPbeta1] / Sadanand Gaikwad". 2007. http://d-nb.info/991916484/34.

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34

Sobota, Radoslaw Mikolaj [Verfasser]. "Regulation of IL-6 signal transduction, contributions of the signal regulatory protein (SIRP) and cyclic AMP / vorgelegt von Radoslaw, Mikolaj Sobota." 2007. http://d-nb.info/986552712/34.

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35

Chien-Hao and 黃建豪. "Zebrafish regulator of G protein signal 7（RGS7）：temperal pattern and involved in cardiac development." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/96555510222759337565.

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碩士<br>中山醫學大學<br>生化暨生物科技研究所<br>94<br>To date, it is well accepted that Regulator of G-protein signalling（RGS） proteins terminate signalling by accelerating the intrinsic G alpha-GTPase activity and recycling the G-protein complex back to its inactive GDP-bound heterotrimeric configuration. The RGS protein can be divided into 15 subfamilies（RGS1~RGS15） in accordance with the structure and the biological function. The RGS domain, a conserved 120-aa region exists in all RGS proteins, functions as a negative regulator through interacting with activated Gα subunit and turn off the signaling. In addi

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36

Spannagel, Ralf [Verfasser]. "Klonierung und Charakterisierung von Signal-regulatory-Protein β [Beta] in primären Makrophagen der Maus / vorgelegt von Ralf Spannagel". 2004. http://d-nb.info/972279598/34.

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Han, Yuchen [Verfasser]. "Integration of redox and light signals by the regulator protein AppA in Rhodobacter sphaeroides / vorgelegt von Yuchen Han." 2006. http://d-nb.info/982785852/34.

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Madlambayan, Gerard James. "Endogenously produced protein regulators provide feedback signals that regulate the ex vivo expansion of human hematopoietic stem and progenitor cells." 2004. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=94634&T=F.

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Δρόσου, Γεωργία. "Μελέτη του ρόλου του αυξητικού παράγοντα HARP (Heparin Affin Regulatory Peptide) στην αγγειογένεση in vivo". Thesis, 2007. http://nemertes.lis.upatras.gr/jspui/handle/10889/753.

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H HARP (heparin-affin regulatory peptide), γνωστή και ως πλειοτροπίνη (PTN), είναι ένας 18 kDa αυξητικός παράγοντας, ο οποίος έχει υψηλή συγγένεια για την ηπαρίνη. Η HARP έχει πολλαπλές βιολογικές δράσεις, όπως συμμετέχει στη ρύθμιση του κυτταρικού πολλαπλασιασμού, στη μετανάστευση και τη διαφοροποίηση. Επιπλέον η έκφραση της σχετίζεται με την φυσιολογική και καρκινική αγγειογένεση in vitro και in vivo. Στην παρούσα εργασία μελετήθηκε η έκφραση της HARP και των υποδοχέων της, ALK και RPTPβ/ζ, στις διάφορες ημέρες ανάπτυξης της CAM εμβρύου όρνιθας. Επίσης, μελετήθηκε η μείωση της έκφρασης της ε

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Agrawal, Ruchi. "Systemic Profiling of Two Component Signaling Networks in Mycobacterium Tuberculosis." Thesis, 2015. http://etd.iisc.ernet.in/2005/3591.

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Mycobacterium tuberculosis, the causative organism of the disease tuberculosis (TB) in humans, leads to nearly two million deaths each year. This versatile pathogen can exist in highly distinct physiological states such as asymptomatic latent TB infection where bacilli lie dormant or as active TB disease in which the bacilli replicate in macrophages. The pathogenic lifestyle requires the tubercle bacillus to sense and respond to multiple environmental cues to ensure its survival. Such stimuli include hypoxia, nutrient limitation, presence of reactive oxygen and reactive nitrogen intermediates,

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