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Relevant bibliographies by topics / Signal transduction / Dissertations / Theses

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Dissertations / Theses on the topic 'Signal transduction'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Lioubin, Mario N. "Fms signal transduction, p150S̳h̳i̳p̳ : a signal transduction molecule with inositol 5-phosphatase activity /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/6339.

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2

Stefansson, Anne. "Mechanisms of Integrin Signal Transduction." Doctoral thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8221.

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<p>Integrins are a protein family of cell surface receptors, expressed in all cell types in the human body, except the red blood cells. Besides their importance in mediating physical connections with the surrounding environment, the integrin family members are also vital signalling mediators. They have no intrinsic kinase activity; instead the signals are transduced through conformational changes. </p><p>In this thesis, work is presented which is focused on molecular mechanisms of integrin signal transduction. The signal transduction was first studied from a structural point of view, determini

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3

Ghislain, Julien Johannes. "Type I interferon signal transduction." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0015/NQ27652.pdf.

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4

Partch, Carrie L. Sancar Aziz. "Signal transduction mechanisms of cryptochrome." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,267.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biochemistry and Biophysics." Discipline: Biochemistry and Biophysics; Department/School: Medicine.

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5

Vieira, Elaine. "Signal Transduction of Glucagon Secretion." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6319.

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6

Priestley, Alistair James. "Signal transduction pathways in plants." Thesis, Lancaster University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250567.

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7

James, L. R. "Calcium signal transduction in astrocytes." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.605022.

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Ca<sup>2+</sup> signals can exhibit great spatiotemporal complexity, leading to the hypothesis that the dynamics of Ca<sup>2+</sup> signals may allow astrocytes to discriminate between stimuli. An <i>in vitro</i> model system of primary cerebellar and cortical astrocytes was tailored to test this hypothesis, by comparing the kinetics of the Ca<sup>2+</sup> signal evoked by different receptor agonists. It was found that known physiological agonists triggered highly heterogeneous responses, but there were no systematic trends in the specific kinetic parameters of Ca<sup>2+</sup> signals that dep

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8

Simonson, Michael Scott. "Signal Transduction in Diabetic Nephropathy." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1343145610.

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9

Pat, Betty Kila. "Signal transduction pathways in renal fibrosis /." St. Lucia, Qld, 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17739.pdf.

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10

Sundström, Magnus. "Signal Transduction in Mast Cell Migration." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1474.

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<p>Mast cells are essential effector cells in the immune system as they release several inflammatory mediators. An accumulation of mast cells has been described in inflammatory conditions such as asthma and allergic rhinitis. Increased mast cell number, in the skin and other organs, is also a characteristic in mastocytosis, a disease without an effective treatment. One explanation for the increase in mast cell number is migration of mast cells in the tissue. In our studies we utilised mast cell lines, including HMC-1; cell lines transfected with the <i>c-kit</i> gene; and <i>in vitro</i> devel

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11

Valdimarsdóttir, Gudrun. "TGFβ Signal Transduction in Endothelial Cells". Doctoral thesis, Uppsala University, Ludwig Institute for Cancer Research, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4284.

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<p>Transforming growth factor β (TGFβ) is a multifunctional cytokine that is involved in many biological effects, such as proliferation, migration, differentiation and cell survival. TGFβ regulates cellular responses by binding to a heteromeric complex of type I and type II serine/threonine kinase receptors. The type I receptor, termed activin receptor-like kinase (ALK), acts downstream of the type II receptor and propagates the signal to the nucleus by phosphorylating receptor regulated Smads (R-Smads). The activated R-Smads can associate with the common partner Smad, Smad4, and this complex

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12

Ulrich, Luke. "Comparative Genomics of Microbial Signal Transduction." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/7632.

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High-throughput genome processing, sophisticated protein sequence analysis, programming, and information management were used to achieve two major advances in the comparative genomics of microbial signal transduction. First, an integrated and flexible bioinformatics platform and the Microbial Signal Transduction database (MiST) were developed, which facilitated the genome-wide analysis of bacterial signal transduction. This platform was used successfully for the high-throughput identification and classification of signal transduction proteins in more than 300 archaeal and bacterial organisms.

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13

Dukkipati, Abhiram. "Signal transduction by short-wavelength opsins." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2006. http://proquest.umi.com/login?COPT=REJTPTU0NWQmSU5UPTAmVkVSPTI=&clientId=3739.

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14

Lennartsson, Johan. "Stem Cell Factor Induced Signal Transduction." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5291-4/.

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15

Sundström, Magnus. "Signal transduction in mast cell migration /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5130-6/.

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16

McKay, Jodi Ho-Jung. "HRas intracellular trafficking and signal transduction." [Ames, Iowa : Iowa State University], 2007.

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17

Brownlie, Zoe. "Regulation of signal transduction by RGS4." Connect to e-thesis, 2007. http://theses.gla.ac.uk/124/.

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Thesis (Ph.D.) - University of Glasgow, 2007.<br>Ph.D. thesis submitted to the Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, 2007. Includes bibliographical references.

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18

Kim, Hyun Ji. "Development and signal transduction in Dictyostelium." Thesis, University of Oxford, 1999. http://ora.ox.ac.uk/objects/uuid:4ed80c6e-adc8-46d6-aeaf-c853cef7af77.

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Dictyostelium, is a simple eukaryote that multiplies as separate amoebae. However when nutrients are no longer available it embarks on a developmental programme in which the amoebae collect together by chemotaxis and the resulting aggregates eventually transform into fruiting bodies consisting of a cluster of spores held up on a cellular stalk. The entire process of development normally takes about 24 hours. However there are mutants, termed rapidly developing mutants (rde) which complete development in about two-thirds of this time. RdeA null mutants have been reported to have elevated levels

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19

Brownlie, Zoe M. "Regulation of signal transduction by RGS4." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/124/.

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In the present study, the function and the mechanism of action of RGS4, a member of a family of proteins called Regulators of G protein Signalling (RGS) was investigated. A C-terminal fluorescent tag on RGS4 confirmed that transiently transfected RGS4 was predominantly cytosolic and underwent translocation to the plasma membrane of HEK293T cells following co-expression of Gi1, the 2A-adrenoceptor, or agonist activated 2A-adrenoceptor. This translocation of RGS4 to the plasma membrane was most pronounced with the co-expression of the constitutively active GTPase deficient Gi1 Q204L. High-affini

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20

Lillemeier, Bjorn Freimut. "Signal transduction through JAKS and STATS." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368696.

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21

Broughton, Nicola Ann. "Specificity in JAK/STAT signal transduction." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300540.

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22

Ainsworth, Paul. "Chemotaxis signal transduction in Campylobacter jejuni." Thesis, University of Leicester, 2014. http://hdl.handle.net/2381/28667.

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The bacterium Campylobacter jejuni is the most common cause of food borne disease in the UK, causing a 5-7 day enteritis including profuse watery diarrhoea, abdominal pain, fever, headache and occasionally vomiting. In rare cases leading to the paralysing autoimmune disease, Guillain-Barré syndrome. C. jejuni are highly motile cells, propelled through the environment by flagella, their motility is directed through a behaviour called chemotaxis. Cells are able to detect attractants or repellents and reposition the cell accordingly. Chemotaxis is central to C. jejuni colonisation as non-motile a

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23

Wang, Haojie. "Na+/K+-ATPase and Signal Transduction." University of Toledo Health Science Campus / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=mco1147300366.

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24

Coelho, Edgar Duarte de Jesus Valente Marques. "Synaptosomal signal transduction in Alzheimer's disease." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/7418.

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Mestrado em Biomedicina Molecular<br>Alzheimer’s Disease (AD) is characterized by the presence of amyloid plaques (APs) and neurofibrillary tangles (NFTs), which consist of Abeta aggregates and hyperphosphorylated tau, respectively. It is known that increasing Abeta concentrations precede NFT production. Moreover, several lines of evidence suggest that the increase in APP and tau phosphorylation is the result of Abeta neurotoxicity. Although, the precise effects of the neurotoxic peptide on APP and tau phosphorylation remain yet to be fully elucidated. Synapses exhibit high concentratio

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25

Atherton, Philip James. "Signal transduction in skeletal muscle mediating responses to phenotype altering signals." Thesis, University of Central Lancashire, 2005. http://clok.uclan.ac.uk/8584/.

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Skeletal muscle phenotype, size and function respond to exercise, disease and ageing. The aim of this thesis was to investigate the signal transduction pathways responsible for selected skeletal muscle phenotype and size changes. Myostatin, recently identified as a negative regulator of muscle mass was exposed at 10 ng ml 4 to C2C12 cells, and using cDNA genome-wide profiling, was shown to act as a transcriptional suppressor. Furthermore, in these cells myostatin significantly (n8, p<0.05) reduced phosphorylation of components in the P1-3K pathway: PKB Ser473 -30 %, mTOR Ser2448 -50 %, p70 S6K

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26

Schlesner, Matthias. "The halobacterium salinarum taxis signal transduction network." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-102084.

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27

Weismüller, Marco [Verfasser]. "Simulation of signal transduction pathways / Marco Weismüller." Ulm : Universität Ulm. Fakultät für Informatik, 2004. http://d-nb.info/1015439071/34.

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28

Gong, Yunchen 1965. "Analyses of alternative cell signal transduction pathways." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85552.

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Living cells keep sensing the changes in their environments, mostly, via cell surface receptors for different ligands. Attachment-dependent cells are sensitive to alterations in extracellular matrix (ECM). ECM is not only required for cell survival, but also prerequisite for epidermal growth factor (EGF) to stimulate cell proliferation. The receptors for the majority of ECM components are integrins and the receptor for EGF is EGF receptor (EGFR). When bound by their ligands, integrins and EGFR induce signal transduction cascades composed of alternative pathways. A quantitative assessmen

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29

Cieslak, Alicja. "Two-component signal transduction in Actinobacillus actinomycetemcomitans." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101710.

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While some strains of Actinobacillus actinomycetemcomitans serve as causative agents of Localized Aggressive Periodontitis (LAP), there are strains of A. actinomycetemcomitans that live as members of the microflora in the oral cavities of periodontally healthy individuals. Two-component signal transduction is an important determinant of bacterial behaviour and plays an essential role in the regulation of virulence factors. Hence, our study investigates the two-component systems (TCSs) among A. actinomycetemcomitans strains of varying virulence levels. Among the groups of highly and mildly viru

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30

Whitworth, Emma Jane. "Adrenocortical proliferation and signal transduction 'in vitro'." Thesis, Queen Mary, University of London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415058.

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31

Valejev, Najl V. "In silico analysis of signal transduction proteins." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432258.

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32

Chang, Wen-Tsan. "Molecular studies of signal transduction and development." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360212.

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33

Dixon, Mark. "Signal transduction mechanisms involved in hepatocyte proliferation." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245710.

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34

Bellamy, Tomas Cynric. "Nitric oxide signal transduction in the cerebellum." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367871.

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35

Onley, Catherine Mary. "Glycoprotein VI signal transduction in human platelets." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615707.

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36

Yu, Xiang. "Wingless signal transduction during Drosophila embryonic development." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624339.

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37

May, Michael Jonathan. "Cytokine-induced signal transduction in endothelial cells." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339150.

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38

Latimer, Heather Ruth. "Mechanisms of H₂O₂-induced signal transduction." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3671.

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Reactive oxygen species (ROS), including H2O2, are produced as unavoidable by-products of aerobic respiration, leading to oxidative stress and the initiation and development of many diseases, particularly age-associated diseases. Cells have evolved antioxidant and repair enzymes to protect against ROS, including the 2-Cys peroxiredoxins (Prx) family, a group of extremely abundant, highly conserved peroxidases. H2O2 initiates protective cell responses that include increasing expression of these enzymes. Counterintuitively, typical 2-Cys Prx have also been shown to have important roles in promot

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39

Manne, Bhanu Kanth. "CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/340495.

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Physiology<br>Ph.D.<br>Platelets are involved in many processes ranging from fighting microbial infections and triggering inflammation to promoting tumor angiogenesis and metastasis. Nevertheless, the primary physiological function of platelets is to act as essential mediators in maintaining homeostasis of the circulatory system by forming hemostatic thrombi that prevent blood loss and maintain vascular integrity. CLEC-2 is a C-type lectin-like receptor that is highly expressed in platelets and lesser extent, in other cell types such as activated dendritic cells and B cells. Rhodocytin was the

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40

Haberl, Florian Max. "Molecular modeling studies on signal transduction proteins." kostenfrei, 2008. http://www.opus.ub.uni-erlangen.de/opus/volltexte/2008/1083/.

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41

Hung, Hiu Wai. "Signal transduction mechanism in xenopus presynaptic differentiation /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202003%20HUNG.

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42

Tomsett, Michael. "Signal transduction in helical oligomers and polymers." Thesis, University of Bristol, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.742998.

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43

Legewie, Stefan. "Systems biological analyses of intracellular signal transduction." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/16018.

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An der Interpretation extrazellulärer Signale beteiligte Regulationsnetzwerke sind von zentraler Bedeutung für alle Organismen. Extrazelluläre Signale werden gewöhnlich durch enzymatische Kaskaden innerhalb weniger Minuten in den Zellkern weitergeleitet, wo sie langsame Änderungen der Genexpression bewirken und so das Schicksal der Zelle beeinflussen. Im ersten Teil der Arbeit wird durch mathematische Modellierung untersucht, wie die MAPK Kaskade Signale von der Zellmembran in den Kern weiterleitet. Es wurden Netzwerkeigenschaften herausgearbeitet, die verhindern, dass die MAPK Kaskade fälschl

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44

Young, Jared. "Carbon dioxide signal transduction in Arabidopsis guard cells." Diss., Connected to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3187824.

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Thesis (Ph. D.)--University of California, San Diego, 2005.<br>Title from first page of PDF file (viewed March 6, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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45

Borowski, Peter. "Stochastic dynamics in olfactory signal transduction and development." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2006. http://nbn-resolving.de/urn:nbn:de:swb:14-1159519135136-22697.

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The purpose of the senses of animals (and humans) is to translate information available in the external environment into internal information that can be processed by the brain. In the case of the olfactory sense -- the sense of smell -- this is information about the type and concentration of odourants. In the last 15 years major progress has been made in the experimental understanding of the first two stages of the olfactory sense: the signal transduction inside the cilia of the olfactory receptor neurons and the first 'relay station' in the brain, the olfactory bulb, as well as the connectio

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46

Adams-Phillips, Lori C. "Molecular analysis of ethylene signal transduction in tomato." Texas A&M University, 2003. http://hdl.handle.net/1969.1/1599.

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The plant hormone ethylene plays an important role in plant growth, development, and physiology. One of the critical components of the ethylene signal transduction pathway, ctr1 (constitutive triple response), was identified using a particularly useful seedling screen that takes advantage of the profound effects ethylene has on etiolated seedlings, known as triple response. CTR1 is one of six Arabidopsis MAPKKKs that are related to the Raf kinases, and acts as a negative regulator of ethylene response. In this study, isolation and characterization of a family of CTR1-like genes in tomato is re

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47

Bergström, Rosita. "Epigenetic Regulation of Replication Timing and Signal Transduction." Doctoral thesis, Uppsala universitet, Molekylär cellbiologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8413.

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Upon fertilization the paternal and maternal genomes unite, giving rise to the embryo, with its unique genetic code. All cells in the human body are derived from the fertilized ovum: hence they all contain (with a few exceptions) the same genetic composition. However, by selective processes, genes are turned on and off in an adaptable, and cell type-specific, manner. The aim of this thesis is to investigate how signals coming from outside the cell and epigenetic factors residing in the cell nucleus, cooperate to control gene expression. The transforming growth factor-β (TGF-β) superfamily cons

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48

Roberts, Jonathan A. "Signal transduction of transfected and native P2Y receptors." Thesis, University of Leicester, 1998. http://hdl.handle.net/2381/30614.

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This thesis looks at the turkey P2Y1, human P2Y2, human P2Y4 and rat P2Y6 receptors transfected into the human astrocytoma null cell line 1321N1 to investigate signalling pathways linking G protein receptor activation to tyrosine phosphorylation, MAPK and mitogenesis. This was compared with results for the native primary cell preparation of rat brain microvascular endothelial cells. Previous work by others and us has established that all 1321N1 transfected P2Y receptors are strongly linked to an increase in PLC activation. Neither the turkey P2Y1 or human P2Y2 receptors were coupled to an incr

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49

Dikic, Inga. "Signal Transduction by Proline-Rich Tyrosine Kinase Pyk2." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5316-3/.

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50

Bergström, Rosita. "Epigenetic regulation of replication timing and signal transduction /." Uppsala : Acta Universitatis Upsaliensis, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8413.

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