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Dissertations / Theses on the topic 'Signaling lipid'

Author: Grafiati

Published: 9 November 2024

Last updated: 31 July 2025

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1

Benarab, Ammar. "Harnessing endothelial lipid signaling for ischemic stroke protection." Electronic Thesis or Diss., Université Paris Cité, 2021. http://www.theses.fr/2021UNIP5197.

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Justification : La fonction cérébrovasculaire est essentielle à la santé du cerveau, et les voies de protection vasculaire endogènes peuvent fournir des cibles thérapeutiques pour les troubles neurologiques. La signalisation S1P (sphingosine 1-phosphate) coordonne les fonctions vasculaires dans d'autres organes et les modulateurs S1P1 (récepteur S1P-1), y compris le fingolimod, sont prometteurs pour le traitement de l'AVC ischémique et hémorragique. Cependant, S1P1 coordonne également le trafic lymphocytaire, et les lymphocytes sont actuellement considérés comme la principale cible thérapeutiq

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2

Cheong, Fei Ying. "Regulation of lipid signaling at the Golgi by the lipid phosphatases hSAC1 and OCRL1." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:16-opus-71011.

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3

Herman, Moreno Maria Dolores. "Structural studies of proteins in apoptosis and lipid signaling." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8212.

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Signaling pathways control the fate of the cell. For example, they promote cell survival or commit the cell to death (apoptosis) in response to cell injury or developmental stimuli, decisions, which are vital for the proper development and functioning of metazoan. Tight control of such pathways is essential; dysregulation of apoptosis can disrupt the delicate balance between cell proliferation and cell death ending up in pathological processes, including cancer, autoimmunity diseases, inflammatory diseases, or degenerative disorders. We have used a structural genomic approach to study the stru

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4

Aivazian, Dikran A. (Dikran Arvid) 1971. "Lipid-protein interactions of immunoreceptor signaling subunit cytoplasmic domains." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/8583.

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Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 2001.<br>Vita.<br>Includes bibliographical references (leaves 116-131).<br>Protein-lipid interactions are emerging as key components of cellular processes such as protein and membrane trafficking and cell-cell signaling. Many proteins bind lipid reversibly, including cytoplasmic proteins involved in signal transduction, such as Ras and Src. Membrane binding is vital for the function of these signaling proteins both through co-localization with other signaling proteins as well as effects of lipid on intrinsic activities. I

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5

Secor, Jordan Douglas. "Phytochemical Antioxidants Induce Membrane Lipid Signaling in Vascular Endothelial Cells." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338391553.

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6

Cody, West Kime. "Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program." Kyoto University, 2018. http://hdl.handle.net/2433/232302.

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7

Kline, Michelle A. "Membrane cholesterol regulates vascular endothelial cell viability, function, and lipid signaling." Connect to resource, 2008. http://hdl.handle.net/1811/32175.

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8

Sadhukhan, Sushabhan. "Metabolism & Signaling of 4-Hydroxyacids: Novel Metabolic Pathways and Insight into the Signaling of Lipid Peroxidation Products." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1339171892.

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9

Kilaru, Aruna. "Discovery of Anandamide, a Novel Lipid Signaling Molecule in Moss and Its Implications." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/4771.

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10

Herrera-Velit, Patricia. "Bacterial lipopolysaccharides signaling pathways in mononuclear phagocytes involve protein and lipid kinases." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0034/NQ27161.pdf.

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11

Xia, Ye. "THE ROLE OF CUTICLE, FATTY ACIDS, AND LIPID SIGNALING IN PLANT DEFENSE." UKnowledge, 2010. http://uknowledge.uky.edu/plantpath_etds/10.

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Systemic acquired resistance (SAR) is initiated upon recognition of specific microbial effectors by cognate plant resistance proteins and immunizes distal tissues of plants against secondary infections. SAR involves the generation of a mobile signal at the site of primary infection, which then translocates to and activates defense responses in the distal tissues via some unknown mechanism(s). This study shows that an ACYL CARRIER PROTEIN 4 (ACP4), GLABRA1 (GL1) and ACYL CARRIER BINDING PROTEINS (ACBP) are required for the processing of the mobile SAR signal in distal tissues of Arabidopsis. Al

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12

Yecies, Jessica. "SREBP: A Key Effector of mTORC1 Signaling in Metabolism and Cancer." Thesis, Harvard University, 2011. http://dissertations.umi.com/gsas.harvard:10023.

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The mammalian target of rapamycin complex 1 (mTORC1), a master regulator of cell growth and proliferation, is aberrantly activated in cancer, genetic tumor syndromes and obesity. Much progress has been made to understand the upstream pathways that regulate mTORC1, most of which converge upon its negative regulator, the Tuberous Sclerosis Complex (TSC) 1-TSC2 complex. However, the cell intrinsic consequences of aberrant mTORC1 activation remain poorly characterized. Using systems in which mTORC1 is constitutively activated by genetic loss of TSC1 or TSC2 and pharmacologically inhibited by treat

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13

Unnerståle, Sofia. "NMR Investigations of Peptide-Membrane Interactions, Modulation of Peptide-Lipid Interaction as a Switch in Signaling across the Lipid Bilayer." Licentiate thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-59534.

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The complexity of multi cellular organisms demands systems that facilitate communicationbetween cells. The neurons in our brains for instance are specialized in this cell-cellcommunication. The flow of ions, through their different ion channels, across the membrane, isresponsible for almost all of the communication between neurons in the brain by changing theneurons membrane potentials. Voltage-gated ion channels open when a certain thresholdpotential is reached. This change in membrane potential is detected by voltage-sensors in the ionchannels. In this licentiate thesis the Homo sapiens volt

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14

Mok, Crystal Yin Lam. "The role of lipid accumulation and insulin signaling in adipose tissue macrophage polarization." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648349.

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15

Rapovy, Shannon Marie. "Characterization of the Physico-chemical Properties of the Novel Signaling Lipid Diacylglycerol Pyrophosphate." Kent State University Honors College / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1335810423.

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16

Cheong, Fei Ying [Verfasser], and Peter PD [Akademischer Betreuer] Mayinger. "Regulation of lipid signaling at the Golgi by the lipid phosphatases hSAC1 and OCRL1 / Fei Ying Cheong ; Betreuer: Peter PD Mayinger." Heidelberg : Universitätsbibliothek Heidelberg, 2007. http://d-nb.info/1178796647/34.

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17

Gyllberg, Hanna. "Prion-infection and Cellular Signaling : Influence of scrapie-infection on lipid raft-associated proteins." Doctoral thesis, Stockholm : Department of Biochemistry and Biophysics, Stockholm university, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7115.

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18

Rimmerman, Neta. "The signaling properties in sensory neurons of the novel endogenous lipid N-palmitoyl glycine." [Bloomington, Ind.] : Indiana University, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3283743.

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Thesis (Ph.D.)--Indiana University, Dept. of Psychological and Brain Sciences and Program in Neuroscience, 2007.<br>Source: Dissertation Abstracts International, Volume: 68-10, Section: B, page: 6514. Adviser: J. Michael Walker. Title from dissertation home page (viewed May 21, 2008).

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19

Chapagai, Danda P. "Biochemical Characterization of SBIP-470 and its role in SA-mediated Signaling in Plants." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etd/2428.

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Salicylic acid binding protein 2 (SABP2) is known to play a key role in Salicylic acid mediated defense pathway. SBIP-470 is SABP2 interacting protein that might be putatively involved in transfer of lipids. SBIP-470 was cloned without the signal peptide and expressed in E. coli. In vitro lipid binding assay using recombinant SBIP-470 failed to detect lipid binding. In vitro lipid transfer assay showed recombinant SBIP-470 does not transfer phospholipid. Study has shown that SBIP-470 is highly inducible upon infection with viral as well as bacterial pathogens. Induction of SBIP-470 expression

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20

BERTOLIO, REBECCA. "Sterol Regulatory Element Binding Protein couples mechanical cues to lipid metabolism." Doctoral thesis, Università degli Studi di Trieste, 2020. http://hdl.handle.net/11368/2963753.

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Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several enzymes required for endogenous cholesterol, fatty acid, triacylglycerol, and phospholipid synthesis1. In vertebrates, SREBP activation is mainly controlled by a complex and well-characterized feedback mechanism mediated by cholesterol, a crucial bio-product of the SREBP-activated mevalonate pathway. In this work, we identified the acto-myosin contractility and mechanical forces imposed by the extracellular matrix (

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21

Oakley, Fredrick Daniel. "Biology of redox active endosomal signaling in response to Il-1-Beta." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1045.

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Interleukin-1-beta (IL-1β) is a potent proinflammatory cytokine. A primary outcome of IL-1β signaling is the activation of NFκB, a transcription factor that induces a large number of immune molecules, apoptotic factors, anti-apoptotic factors, and other transcription factors. Recent work has demonstrated that the activation of NFκB involves a multistep redox-signaling cascade that requires endocytosis of the interleukin receptor (IL-1R1)/ligand pair and superoxide production by NADPH oxidase 2 (Nox2) within the resulting newly formed early endosome. Hydrogen peroxide produced by the rapid dism

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22

Searcy, James Lucas. "LIPID SIGNALING IN BRAIN AGING AND ALZHEIMER'S DISEASE: PHARMACOLOGICALLY TARGETING CHOLESTEROL SYNTHESIS, TRANSPORT AND METABOLISM." Lexington, Ky. : [University of Kentucky Libraries], 2009. http://hdl.handle.net/10225/1147.

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Thesis (Ph. D.)--University of Kentucky, 2009.<br>Title from document title page (viewed on May 12, 2010). Document formatted into pages; contains: xiv, 183 p. : ill. (some col.). Includes abstract and vita. Includes bibliographical references (p. 158-177).

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23

Shrivastava, Shamit. "Non-linear solitary sound waves in lipid membranes and their possible role in biological signaling." Thesis, Boston University, 2014. https://hdl.handle.net/2144/11049.

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Thesis (Ph. D.)--Boston University<br>Biological macromolecules self-assemble under entropic forces to form a dynamic 20 interfacial medium where the elastic properties arise from the curvature of the entropic potential of the interface. Elastic interfaces should be capable of propagating localized perturbations analogous to sound waves. However, (1) the existence and (2) the possible role of such waves in affecting biological functions remain unexplored. Both these aspects of "sound' as a signaling mechanism in biology are explored experimentally on mixed monolayers of lipids-fluorophores-pro

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24

Andrews, Shantaya Biunca, Timothy Audam, and Dhirendra Dr Kumar. "Characterization of SIP470, A Plant Lipid Transfer Protein, and its Role in Plant Defense Signaling." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/44.

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Plants are resilient organisms that are continually evolving and continue to withstand an adverse and dynamic world. SABP2-interacting protein (SIP)-470 is a non-specific lipid transfer protein (nsLTP) that was identified in tobacco. SIP470 was discovered during a yeast two-hybrid screening with SABP2, which is an important methyl esterase enzyme which catalyzes the conversion of immobile MeSA into active salicylic acid (SA) during pathogenic challenge. SA activation and mobility allows for immunity to be carried to other, non-infected parts of the plant. This induced responses is called syste

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25

Cinque, A. "PLEIOTROPIC EFFECTS OF PERIFOSINE ON GLIOBLASTOMA CELLS SURVIVAL: ALTERED MEMBRANE LIPID METABOLISM AND CELL SIGNALING." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/364862.

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Glioblastoma multiforme (GBM) is the most frequent and aggressive malignant tumor of the central nervous system in adults. Despite decades of experimentation to improve the outcome of patients with GBM, this type of neoplasm remains one of the most lethal human cancers.Therefore, the need to test different and new agents for efficacy and safety is urgent. Perifosine (PF) is a synthetic lipid analogue belonging to a relatively new class of structurally related antitumor agents: the alkylphospholipids (APLs). PF exhibits potent antineoplastic activity against a multitude of cancer cell lines and

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26

Homan, Edwin. "Discovery of Novel Lipid Pathways associated with the Metabolic Syndrome." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10343.

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The prevalence of obesity and type 2 diabetes has increased at alarming rates in recent decades. These diseases are prominent components of the metabolic syndrome, which is characterized by marked dyslipidemia. Adipose tissue contributes to the development of obesity-related diabetes through increased release of hormones and non-esterified fatty acids. The development of sensitive analytical tools for the broad detection of lipid biomolecules, such as liquid chromatographymass spectrometry (LC-MS), has spurred interest in the molecular determinants of the metabolic syndrome. The development of

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27

Filho, Edismauro Garcia Freitas. "O papel de gangliosídeos específicos como moduladores da liberação de mediadores de mastócitos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-21052015-180820/.

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Os mastócitos são células multifuncionais do sistema imunológico que participam em diversos processos biológicos. As funções dos mastócitos estão diretamente relacionados com a sua ativação e, subsequente, liberação de mediadores químicos. Os eventos iniciais da ativação dos mastócitos e da transdução de sinais ocorrem em microdomínios lipídicos (lipid rafts) da membrana plasmática. Os gangliosídeos derivados do GD1b são constituintes dos lipid rafts de mastócitos de roedores. O intercruzamento destes gangliosídeos pelo mAb AA4, resulta na formação de agregados (caps) na superfície celular e p

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28

Dian, Emese Emöke. "Application of Cultured Neuronal Networks for Use as Biological Sensors in Water Toxicology and Lipid Signaling." Thesis, University of North Texas, 2004. https://digital.library.unt.edu/ark:/67531/metadc5557/.

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This dissertation research explored the capabilities of neuronal networks grown on substrate integrated microelectrode arrays in vitro to be applied to toxicological research and lipid signaling. Chapter 1 details the effects of chlorine on neuronal network spontaneous electrical activity and pharmacological sensitivity. This study demonstrates that neuronal networks can maintain baseline spontaneous activity, and respond normally to pharmacological manipulations in the present of three times the chlorine present in drinking water. The findings suggest that neuronal networks may be used as

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29

Audam, Timothy Ndagi. "Characterization of SIP470, a Family 1 Lipid Transfer Protein and its Role in Plant Stress Signaling." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etd/3103.

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SIP470, a putative tobacco lipid transfer protein, was identified in a yeast two-hybrid screen to interact with SABP2. SABP2 is a critical role in SA-mediated signaling in tobacco and other plants. In vitro studies using purified recombinant SIP470 confirmed that it is a lipid binding protein. In an attempt to determine its role in mediating stress responses, Arabidopsis T-DNA insertion knockout lines lacking SIP470 homolog were used for the analysis. These mutant plants were defective in basal resistance against microbial pathogens. Expression of defense gene PR-1 was also delayed in these mu

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30

Desbourdes, Céline. "Nucléoside diphosphate kinase D : une protéine mitochondriale bifonctionnelle." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV004/document.

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Les nucléosides diphosphate kinases (NDPK) sont essentielles pour la génération des nucléosides triphosphates (NTPs) en utilisant l’ATP et des NDPs. L’isoforme mitochondriale de NDPK (NDPK-D), située dans l’espace intermembranaire des mitochondries, possède deux modes de fonctionnement. Dans le premier mode (« phosphotransfert »), la protéine a une activité de kinase comme les autres enzymes NDPK. Dans ce mode de fonctionnement, NDPK-D produit du GTP pour la protéine optique atrophy 1 (OPA1), une GTPase impliquée dans la fusion des mitochondries, et de l’ADP pour le translocateur à adénine (AN

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31

Kwong, Eric K. "The Role of Sphingosine Kinase 2 in Alcoholic Liver Disease." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5808.

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Alcoholic liver disease (ALD) is one of the most common liver diseases worldwide characterized by the accumulation of lipids within the liver, inflammation and the possibility of progressing to cirrhosis and liver failure. More importantly, there are currently no effective treatments for ALD and liver transplantation remains the only therapeutic option for end-stage liver disease. Previous studies have shown that ALD is a result of a combination of endoplasmic reticulum (ER) stress, lipid metabolism dysregulation and inflammation. It has been previously reported that alcohol disrupts gut micro

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32

Mahammad, Saleemulla. "Cholesterol in T cells homeostasis, plasma membrane organization and signaling /." Doctoral thesis, Stockholm : The Wenner-Gren Institute, Stockholm University, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-38357.

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Diss. (sammanfattning) Stockholm : Stockholms universitet, 2010.<br>At the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 2: Manuscript. Paper 3: In press.

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33

Goswami, Ishan. "Computational and Experimental Investigation of the Critical Behavior Observed in Cell Signaling Related to Electrically Perturbed Lipid Systems." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/97564.

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Problem Statement: The use of pulsed electric fields (PEFs) as a tumor treatment modality is receiving increased traction. A typical clinical procedure involves insertion of a pair of electrodes into the tumor and administration of PEFs (amplitude: ~1 kV/cm; pulse-width: 100 μs). This leaves a zone of complete cell death and a sub-lethal zone where a fraction of the cells survive. There is substantial evidence of an anti-tumor systemic immune profile in animal patients treated with PEFs. However, the mechanism behind such immune profile alterations remains unknown, and the effect of PEFs on ce

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34

Krothapalli, Kartikeya. "Association of plastid lipid metabolism with the activation of systemic acquired resistance in Arabidopsis thaliana." Diss., Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/1058.

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35

Panakova, Daniela. "Lipoprotein particles associate with lipid-linked proteins and are required for long-range Wingless and Hedgehog signaling." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2005. http://nbn-resolving.de/urn:nbn:de:swb:14-1122025765300-27455.

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Morphogens of the Wnt and Hedgehog families are secreted signaling molecules that coordinate growth and patterning of many different tissues. Both, Wingless and Hedgehog spread across long distances in developing wing of Drosophila melanogaster. However, both proteins are covalently modified with lipid moieties. The mechanisms that allow long-range movement of such hydrophobic molecules are unclear. Like Wingles and Hedgehog, glycosylphosphatidylinositol (gpi)-linked proteins also transfer between cells with their lipid anchor intact. It has been speculated that gpi-linked proteins and lipid-l

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36

Klose, Jana. "The role of lipid signaling and metabolism in morphogenesis and pathogenesis of the fungal pathogen Ustilago maydis." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/31085.

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The phytopathogenic fungus Ustilago maydis is obligately dependent on infection of maize to complete the sexual phase of its life cycle. Mating interactions between budding cells establish an infectious filamentous cell type that invades the host, induces tumors, and forms teliospores. The yeast-to-filamentous morphological transition is regulated by cAMP and MAPK signaling pathways known to control the pathogenic development in the host. The signals influencing this transition during infection have not yet been identified. In this study, we demonstrated that lipids triggered the dimorphic swi

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37

Efe, Jem A. "Vacuole biogenesis, function, and size control in S. cerevisiae central roles for membrane trafficking and lipid signaling /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3292284.

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Thesis (Ph. D.)--University of California, San Diego, 2007.<br>Title from first page of PDF file (viewed October 8, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 166-184).

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38

Newton, Hannah S. "Potassium channels and adenosine signaling in T cells of head and neck cancer patients." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1603713656776019.

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Mandal, Mihir Kumar. "MOLECULAR AND BIOCHEMICAL CHARACTERIZATION OF OLEATE- AND GLYCEROL-3-PHOSPHATE-REGULATED SIGNALING IN PLANTS." UKnowledge, 2012. http://uknowledge.uky.edu/plantpath_etds/3.

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Oleic acid (18:1), a monounsaturated fatty acid (FA), is synthesized upon desaturation of stearic acid (18:0) and this reaction is catalyzed by the plastidal enzyme stearoyl-acyl carrier protein-desaturase (SACPD). A mutation in the SSI2/FAB2 encoded SACPD lowers 18:1 levels, which correlates with induction of various resistance (R) genes and increased resistance to pathogens. Genetic and molecular studies have identified several suppressors of ssi2 which restore altered defense signaling either by normalizing 18:1 levels or by affecting function(s) of a downstream component. Characterization

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40

Paquette, Sara Montminy. "Evasion of LPS-TLR4 Signaling as a Virulence Determinate for Yersinia pestis." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/458.

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Yersinia pestis, the gram-negative causative agent of plague, is a master of immune evasion. The bacterium possesses a type three secretion system which translocates Yop effector proteins into host immune cells to inhibit a number of immune and cell signaling cascades. Interestingly, this apparatus is not expressed at low temperatures such as those found within the flea vector and is therefore neither in place nor functional when the bacteria are first transmitted into a mammalian host. However, the bacterium is still able to avoid activating the immune system, even very early during infection

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41

Hodson, Jane E. "Tobacco Phospholipase D β1: Molecular Cloning and Biochemical Characterization". Thesis, University of North Texas, 2002. https://digital.library.unt.edu/ark:/67531/metadc3341/.

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Transgenic tobacco plants were developed containing a partial PLD clone in antisense orientation. The PLD isoform targeted by the insertion was identified. A PLD clone was isolated from a cDNA library using the partial PLD as a probe: Nt10B1 shares 92% identity with PLDβ1 from tomato but lacks the C2 domain. PCR analysis confirmed insertion of the antisense fragment into the plants: three introns distinguished the endogenous gene from the transgene. PLD activity was assayed in leaf homogenates in PLDβ/g conditions. When phosphatidylcholine was utilized as a substrate, no significant difference

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42

Buscató, Arsequell Estel·la [Verfasser], Ewgenij [Akademischer Betreuer] Proschak, and Dieter [Akademischer Betreuer] Steinhilber. "Synthesis and in vitro evaluation of lipid signaling modulators / Estella Buscató Arsequell. Gutachter: Dieter Steinhilber ; Ewgenij Proschak. Betreuer: Ewgenij Proschak." Frankfurt am Main : Univ.-Bibliothek Frankfurt am Main, 2013. http://d-nb.info/1046622684/34.

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Mahon, Robert Norman III. "Direct Inhibition of CD4+ T-cell Activation by Mycobacterium tuberculosis Cell Wall Glycolipids." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1275668686.

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44

Yu, Lingli. "Nerve Growth Factor Signaling from Membrane Microdomain to Nucleus : Differential Regulation by Caveolins." Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2012. http://tel.archives-ouvertes.fr/tel-00796393.

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At the plasma membrane, both NGF receptors have been shown to localized to lipid rafts, specific subdomains that are enriched in cholesterol, sphingolipids and the presence of caveolin proteins (Cav1 and/or Cav2). The focus of this work is on this membrane microenvironment mediated modulation of NGF signaling which via two receptors: p75NTR and TrkA. In the present work we found that overexpression of Cav-1 in mouse dorsal root ganglia neurons significantly impacted neurite extension. Similarly, overexpression of Cav-1 in PC12 cells strongly inhibits their ability to grow neurites in response

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45

Wehmeyer, Lance. "Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/11346.

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Includes abstract.<br>Includes bibliographical references (leaves 121-158).<br>A recent study from the Hapgood laboratory demonstrated the presence of a novel crosstalk mechanism between the glucocorticoid receptor (GR) and gonadotropin-releasing hormone receptor (GnRHR), indicating an additional direct mechanism for the effects of stress on reproduction. The present study investigated whether this crosstalk between the GR and GnRHR involves the co-localization of these receptors to lipid rafts, providing a specialized distinct region where the receptors can be in close proximity and reciproca

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46

Gorjão, Renata. "Efeito dos ácidos graxos sobre a via de sinalização da interleucina-2 em linfócitos humanos." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-15092008-134403/.

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Neste estudo investigamos os efeitos dos ácidos graxos sobre a função e sinalização intracelular de linfócitos humanos. Os ácidos oléico (OA) e linoléico (LA), em baixas concentrações, estimularam a proliferação celular induzida pela IL-2 através do aumento da fosforilação da proteína PKC-<font face=\"symbol\">Z que levou a um aumento da fosforilação de ERK 1/2. Já os ácidos palmítico (PA), esteárico (SA), DHA e EPA diminuíram a proliferação destas células e inibiram a fosforilação de JAK1 e 3, STAT5, ERK e Akt. Os resultados obtidos são sugestivos de que o efeito inibitório promovido por PA,

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47

Paulino, Rachel Santini. "Estresse oxidativo de duas espécies de macrófitas aquáticas em diferentes condições ambientais em um estuário de região neotropical." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/153368.

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Lajoie, Patrick. "Regulation of receptor signaling and membrane trafficking by beta1,6-branched n-glycans and caveolin-1/cholesterol membrane domain organization." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/336.

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Modification by glycosylation gives proteins a range of diverse functions reflecting their structural variability. N-glycans regulate many biological outcomes in mammalian cells under both normal and pathological conditions. They play a major role in various pathologies such as cancer and lysosomal storage diseases. Interplay between N-glycans and other regulators, such as membrane lipid domains, in the control of signaling pathways remains poorly understood. My thesis therefore focuses on how N-glycans and membrane lipid domains oppose and/or work together at different cellular levels to regu

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Tiwari, Vijay. "Isolation and Heterologous Expression of Putative Tomato Fatty Acid Amide Hydrolase." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etd/3138.

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N-acylethanolamines (NAEs) are derived from a minor membrane lipid constituent N-acylphosphatidylethanolamine and are hydrolyzed by fatty acid amide hydrolases (FAAH) into free fatty acid (FFA) and ethanolamine in both plants and animals. In Arabidopsis, NAE plays an important physiological role in growth/development and response to stress. Although NAEs are reported in tomato, their metabolic pathway remains undiscovered. It is hypothesized that there is a functional FAAH in tomato that hydrolyzes NAEs. To this extent, a putative gene that likely encodes for putative SlFAAH1 protein was ident

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Gatbonton-Schwager, Tonibelle N. "Biological and Chemical Analysis of Small Molecule Activators of Anti-inflammatory and Antioxidant Nrf2-Keap1 Signaling." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1390560628.

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