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Journal articles on the topic 'Signaling lipid'

Author: Grafiati

Published: 9 November 2024

Last updated: 31 July 2025

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1

Korbelik, Mladen, and Albert W. Girotti. "Tumor Lipid Signaling Involved in Hyperoxidative Stress Response: Insights for Therapeutic Advances." Journal of Cellular Signaling 6, no. 2 (2025): 39–47. https://doi.org/10.33696/signaling.6.132.

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Most malignantly transformed cells are metabolically rewired to promote their survival and progression, even under conditions that would be unfavorable for normal counterparts. Arguably the most impactful metabolic transformation and recognized cancer hallmark is the reprogrammed lipid metabolism. Lipids are not only primary constituents of cell membranes but essential participants in fundamental cellular functions including cell signaling, protein regulation, energy provision, inflammation, and cell-cell interaction. Engagement of lipids in critical physiological functions in cells is additio

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Kumar, Vikash, and Sidra Khan. "The Intersection of Lipid Signaling and Metabolism in Cancer and Tuberculosis." Journal of Cellular Signaling 6, no. 2 (2025): 71–82. https://doi.org/10.33696/signaling.6.135.

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Lipids are an essential class of complex biomolecules involved in maintaining cellular energy homeostasis, structural organization and signal transduction. Dysregulated lipid signaling and metabolism have increasingly been reported in various pathological settings like diabetes, cardiomyopathy, neurological pathologies, malignancies and infectious diseases. Recent technological advances in metabolomics and lipidomics have shown enormous complexities and functionalities of lipids. The role of lipid metabolism in maintaining cancer heterogeneity and plasticity is an important hallmark in the dis

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Wang, Xuemin. "Lipid signaling." Current Opinion in Plant Biology 7, no. 3 (2004): 329–36. http://dx.doi.org/10.1016/j.pbi.2004.03.012.

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4

Bickel, Perry E. "Lipid rafts and insulin signaling." American Journal of Physiology-Endocrinology and Metabolism 282, no. 1 (2002): E1—E10. http://dx.doi.org/10.1152/ajpendo.2002.282.1.e1.

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Lipid rafts are domains within the plasma membrane that are enriched in cholesterol and lipids with saturated acyl chains. Specific proteins, including many signaling proteins, segregate into lipid rafts, and this process is important for certain signal transduction events in a variety of cell types. Within the past decade, data have emerged from many laboratories that implicate lipid rafts as critical for proper compartmentalization of insulin signaling in adipocytes. A subset of lipid rafts, caveolae, are coated with membrane proteins of the caveolin family. Direct interactions between resid

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Höglinger, Doris, André Nadler, Per Haberkant, et al. "Trifunctional lipid probes for comprehensive studies of single lipid species in living cells." Proceedings of the National Academy of Sciences 114, no. 7 (2017): 1566–71. http://dx.doi.org/10.1073/pnas.1611096114.

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Lipid-mediated signaling events regulate many cellular processes. Investigations of the complex underlying mechanisms are difficult because several different methods need to be used under varying conditions. Here we introduce multifunctional lipid derivatives to study lipid metabolism, lipid−protein interactions, and intracellular lipid localization with a single tool per target lipid. The probes are equipped with two photoreactive groups to allow photoliberation (uncaging) and photo–cross-linking in a sequential manner, as well as a click-handle for subsequent functionalization. We demonstrat

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Bazan, Nicolas G. "Synaptic lipid signaling." Journal of Lipid Research 44, no. 12 (2003): 2221–33. http://dx.doi.org/10.1194/jlr.r300013-jlr200.

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7

Irvine, R. "Nuclear Lipid Signaling." Science Signaling 2000, no. 48 (2000): re1. http://dx.doi.org/10.1126/stke.2000.48.re1.

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Irvine, R. F. "Nuclear Lipid Signaling." Science Signaling 2002, no. 150 (2002): re13. http://dx.doi.org/10.1126/stke.2002.150.re13.

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Junkins, Sadie, Gabrielle Westenberger, Jacob Sellers, et al. "MKP-2 Deficiency Leads to Lipolytic and Inflammatory Response to Fasting in Mice." Journal of Cellular Signaling 5, no. 1 (2024): 10–23. http://dx.doi.org/10.33696/signaling.5.108.

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The liver plays a crucial role in maintaining homeostasis for lipid and glucose. Hepatic lipid synthesis is regulated by nutritional signals in response to fasting and refeeding. It is known that overnutrition regulates MAPK-dependent pathways that control lipid metabolism in the liver by activating MAPK phosphatase-2 (MKP-2). Uncertainty still exists regarding the regulatory mechanisms and effects of MKP-2 on hepatic response to fasting. We investigated the effect of fasting on the expression of MKP-2 and the impact on hepatic inflammatory response to feeding a high-fat diet (HFD). In this st

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Dowds, C. Marie, Sabin-Christin Kornell, Richard S. Blumberg, and Sebastian Zeissig. "Lipid antigens in immunity." Biological Chemistry 395, no. 1 (2014): 61–81. http://dx.doi.org/10.1515/hsz-2013-0220.

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Abstract Lipids are not only a central part of human metabolism but also play diverse and critical roles in the immune system. As such, they can act as ligands of lipid-activated nuclear receptors, control inflammatory signaling through bioactive lipids such as prostaglandins, leukotrienes, lipoxins, resolvins, and protectins, and modulate immunity as intracellular phospholipid- or sphingolipid-derived signaling mediators. In addition, lipids can serve as antigens and regulate immunity through the activation of lipid-reactive T cells, which is the topic of this review. We will provide an overv

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Benage, MJ, and P. Koulen. "Lipid Signaling in the Retina: A Druggable Target?" International Journal of Ophthalmology & Eye Science 3, no. 3e (2015): 1–2. https://doi.org/10.19070/2332-290X-150008e.

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Retina tissue has comparably high levels of lipids and a number of these lipids are highly relevant to inter- and intracellular signaling. Based on both clinical findings and evidence from animal models of retinal diseases, lipids have been implicated in the pathogenesis of age-related macular degeneration (AMD) and diabetic retinopathy (DR). Of particular interest are studies that show a direct involvement of diets modifying lipid intake and lipid metabolism with retina pathology. For AMD, a disease with age as a predisposing factor and a major cause of visi

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Terao, Ryo, and Hiroki Kaneko. "Lipid Signaling in Ocular Neovascularization." International Journal of Molecular Sciences 21, no. 13 (2020): 4758. http://dx.doi.org/10.3390/ijms21134758.

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Vasculogenesis and angiogenesis play a crucial role in embryonic development. Pathological neovascularization in ocular tissues can lead to vision-threatening vascular diseases, including proliferative diabetic retinopathy, retinal vein occlusion, retinopathy of prematurity, choroidal neovascularization, and corneal neovascularization. Neovascularization involves various cellular processes and signaling pathways and is regulated by angiogenic factors such as vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF). Modulating these circuits may represent a promising strateg

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Huwiler, Andrea, and Josef Pfeilschifter. "Hypoxia and lipid signaling." Biological Chemistry 387, no. 10/11 (2006): 1321–28. http://dx.doi.org/10.1515/bc.2006.165.

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AbstractSufficient oxygen supply is crucial for the development and physiology of mammalian cells and tissues. When simple diffusion of oxygen becomes inadequate to provide the necessary flow of substrate, evolution has provided cells with tools to detect and respond to hypoxia by upregulating the expression of specific genes, which allows an adaptation to hypoxia-induced stress conditions. The modulation of cell signaling by hypoxia is an emerging area of research that provides insight into the orchestration of cell adaptation to a changing environment. Cell signaling and adaptation processes

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Kuźniak, Elżbieta, and Ewa Gajewska. "Lipids and Lipid-Mediated Signaling in Plant–Pathogen Interactions." International Journal of Molecular Sciences 25, no. 13 (2024): 7255. http://dx.doi.org/10.3390/ijms25137255.

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Plant lipids are essential cell constituents with many structural, storage, signaling, and defensive functions. During plant–pathogen interactions, lipids play parts in both the preexisting passive defense mechanisms and the pathogen-induced immune responses at the local and systemic levels. They interact with various components of the plant immune network and can modulate plant defense both positively and negatively. Under biotic stress, lipid signaling is mostly associated with oxygenated natural products derived from unsaturated fatty acids, known as oxylipins; among these, jasmonic acid ha

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Ren, Yuanhao, Wei Wang, Yin Fu, et al. "Comparative Transcriptome Analysis Identifies MAPK Signaling Pathway Associated with Regulating Ovarian Lipid Metabolism during Vitellogenesis in the Mud Crab, Scylla paramamosain." Fishes 8, no. 3 (2023): 145. http://dx.doi.org/10.3390/fishes8030145.

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The mud crab, Scylla paramamosain, has abundant nutrients in the ovary, where numerous lipids accumulate during ovarian maturation. However, the mechanism behind the accumulation of lipids in the ovary of mud crab during ovarian maturation is largely unknown. This study conducted a comparative transcriptome analysis of the ovaries of mud crabs at various stages of ovarian maturation. A total of 63.69 Gb of clean data was obtained, with a Q30 of 93.34%, and 81,893 unigenes were identified, including 10,996 differentially expressed genes (DEGs). After KEGG enrichment of these DEGs, MAPK signalin

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Cocco, Lucio, Alberto M. Martelli, Ottavio Barnabei, and Francesco A. Manzoli. "Nuclear inositol lipid signaling." Advances in Enzyme Regulation 41, no. 1 (2001): 361–84. http://dx.doi.org/10.1016/s0065-2571(00)00017-0.

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Gaur, Pankaj, Maksym Galkin, Sebastian Hauke, et al. "Reversible spatial and temporal control of lipid signaling." Chemical Communications 56, no. 73 (2020): 10646–49. http://dx.doi.org/10.1039/d0cc04146g.

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Zhang, Cuiping, Ke Wang, Lujie Yang, et al. "Lipid metabolism in inflammation-related diseases." Analyst 143, no. 19 (2018): 4526–36. http://dx.doi.org/10.1039/c8an01046c.

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Lipidomics is used to describe the complete lipid profile and network of cellular lipid metabolism. Traditionally, lipids are recognized as general membrane construction and energy storage molecules. Now, lipids are regarded as potent signaling molecules that regulate a multitude of cellular responses.

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Srivatsav, Aswin T., Manjari Mishra, and Shobhna Kapoor. "Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: Fats on the Gunpoint." BioMed Research International 2018 (August 15, 2018): 1–17. http://dx.doi.org/10.1155/2018/6437371.

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Lipid cell membrane composed of various distinct lipids and proteins act as a platform to assemble various signaling complexes regulating innumerous cellular processes which are strongly downregulated or altered in cancer cells emphasizing the still-underestimated critical function of lipid biomolecules in cancer initiation and progression. In this review, we outline the current understanding of how membrane lipids act as signaling hot spots by generating distinct membrane microdomains called rafts to initiate various cellular processes and their modulation in cancer phenotypes. We elucidate t

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Opazo-Ríos, Lucas, Sebastián Mas, Gema Marín-Royo, et al. "Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities." International Journal of Molecular Sciences 21, no. 7 (2020): 2632. http://dx.doi.org/10.3390/ijms21072632.

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Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin resistance response in non-adipose tissue such as myocardium, pancreas, skeletal muscle, liver, and kidney. Serum lipid abnormalities and renal ectopic lipid accumulation have been associated with the development of kidney diseases, in particular diabetic nephropathy. Chronic hyperinsulinemia, often seen in type 2 diabetes, plays a crucial role in blood and liver lipid metabolism abnormalities, thus resulting in

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Zhou, Yong, and John F. Hancock. "Lipid Profiles of RAS Nanoclusters Regulate RAS Function." Biomolecules 11, no. 10 (2021): 1439. http://dx.doi.org/10.3390/biom11101439.

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The lipid-anchored RAS (Rat sarcoma) small GTPases (guanosine triphosphate hydrolases) are highly prevalent in human cancer. Traditional strategies of targeting the enzymatic activities of RAS have been shown to be difficult. Alternatively, RAS function and pathology are mostly restricted to nanoclusters on the plasma membrane (PM). Lipids are important structural components of these signaling platforms on the PM. However, how RAS nanoclusters selectively enrich distinct lipids in the PM, how different lipids contribute to RAS signaling and oncogenesis and whether the selective lipid sorting o

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Toncan, Fiorenzo, Radha Raman Raj, and Mi-Jeong Lee. "Dynamics of Fatty Acid Composition in Lipids and Their Distinct Roles in Cardiometabolic Health." Biomolecules 15, no. 5 (2025): 696. https://doi.org/10.3390/biom15050696.

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Obesity and cardiometabolic diseases (CMDs) have reached epidemic levels. Dysregulation of lipid metabolism is a risk factor for obesity and CMDs. Lipids are energy substrates, essential components of cell membranes, and signaling molecules. Fatty acids (FAs) are the major components of lipids and are classified based on carbon chain length and number, position, and stereochemistry of double bonds. They exert differential impacts on CMDs, such that saturated fat increases risks while very-long-chain n-3 FAs provide benefits. The functionalities of FAs, modulating membrane properties, acting as

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Mesa-Herrera, Taoro-González, Valdés-Baizabal, Diaz, and Marín. "Lipid and Lipid Raft Alteration in Aging and Neurodegenerative Diseases: A Window for the Development of New Biomarkers." International Journal of Molecular Sciences 20, no. 15 (2019): 3810. http://dx.doi.org/10.3390/ijms20153810.

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Lipids in the brain are major components playing structural functions as well as physiological roles in nerve cells, such as neural communication, neurogenesis, synaptic transmission, signal transduction, membrane compartmentalization, and regulation of gene expression. Determination of brain lipid composition may provide not only essential information about normal brain functioning, but also about changes with aging and diseases. Indeed, deregulations of specific lipid classes and lipid homeostasis have been demonstrated in neurodegenerative disorders such as Alzheimer’s disease (AD) and Park

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Maccarrone, Mauro. "Deciphering Complex Interactions in Bioactive Lipid Signaling." Molecules 28, no. 6 (2023): 2622. http://dx.doi.org/10.3390/molecules28062622.

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Lipids are usually viewed as metabolic fuel and structural membrane components. Yet, in recent years, different families of lipids able to act as authentic messengers between cells and/or intracellularly have been discovered. Such lipid signals have been shown to exert their biological activity via specific receptors that, by triggering distinct signal transduction pathways, regulate manifold pathophysiological processes in our body. Here, endogenous bioactive lipids produced from arachidonic acid (AA) and other poly-unsaturated fatty acids will be presented, in order to put into better perspe

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Bollag, Wendy B. "Lipid signaling in keratinocytes: Lipin-1 plays a PArt." Journal of Lipid Research 57, no. 4 (2016): 523–25. http://dx.doi.org/10.1194/jlr.c067074.

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Brekk, Oeystein Roed, Jonathan R. Honey, Seungil Lee, Penelope J. Hallett, and Ole Isacson. "Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance." Proceedings of the National Academy of Sciences 117, no. 44 (2020): 27646–54. http://dx.doi.org/10.1073/pnas.2003021117.

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Neurons are dependent on proper trafficking of lipids to neighboring glia for lipid exchange and disposal of potentially lipotoxic metabolites, producing distinct lipid distribution profiles among various cell types of the central nervous system. Little is known of the cellular distribution of neutral lipids in the substantia nigra (SN) of Parkinson’s disease (PD) patients and its relationship to inflammatory signaling. This study aimed to determine human PD SN neutral lipid content and distribution in dopaminergic neurons, astrocytes, and microglia relative to age-matched healthy subject cont

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Sibley, D., L. Hazelwood, R. Roof, R. B. Free, Y. Han, and J. Javitch. "Membrane lipid rafts are required for D2 dopamine receptor signaling." European Psychiatry 26, S2 (2011): 910. http://dx.doi.org/10.1016/s0924-9338(11)72615-3.

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IntroductionLipid rafts are specialized membrane microdomains enriched in cholesterol and sphingolipids and are important in the organization of receptor-protein complexes and the regulation of signaling.Objective/aimsGiven the emerging significance of lipids with respect to receptor structure and activation, we investigated the role of lipid rafts and membrane cholesterol on D2 dopamine receptor (DAR) signaling. As the D2 DAR is the molecular target for all antipsychotic drugs, more information about its signaling may help refine therapeutics for schizophrenia.MethodsD2 DAR constructs were ex

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Torres, Manuel, Sebastià Parets, Javier Fernández-Díaz, et al. "Lipids in Pathophysiology and Development of the Membrane Lipid Therapy: New Bioactive Lipids." Membranes 11, no. 12 (2021): 919. http://dx.doi.org/10.3390/membranes11120919.

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Membranes are mainly composed of a lipid bilayer and proteins, constituting a checkpoint for the entry and passage of signals and other molecules. Their composition can be modulated by diet, pathophysiological processes, and nutritional/pharmaceutical interventions. In addition to their use as an energy source, lipids have important structural and functional roles, e.g., fatty acyl moieties in phospholipids have distinct impacts on human health depending on their saturation, carbon length, and isometry. These and other membrane lipids have quite specific effects on the lipid bilayer structure,

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Béaslas, Olivier, François Torreilles, Pierre Casellas, et al. "Transcriptome response of enterocytes to dietary lipids: impact on cell architecture, signaling, and metabolism genes." American Journal of Physiology-Gastrointestinal and Liver Physiology 295, no. 5 (2008): G942—G952. http://dx.doi.org/10.1152/ajpgi.90237.2008.

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Intestine contributes to lipid homeostasis through the absorption of dietary lipids, which reach the apical pole of enterocytes as micelles. The present study aimed to identify the specific impact of these dietary lipid-containing micelles on gene expression in enterocytes. We analyzed, by microarray, the modulation of gene expression in Caco-2/TC7 cells in response to different lipid supply conditions that reproduced either the permanent presence of albumin-bound lipids at the basal pole of enterocytes or the physiological delivery, at the apical pole, of lipid micelles, which differ in their

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Allegra, Alessandro, Giuseppe Murdaca, Giuseppe Mirabile, and Sebastiano Gangemi. "Protective Effects of High-Density Lipoprotein on Cancer Risk: Focus on Multiple Myeloma." Biomedicines 12, no. 3 (2024): 514. http://dx.doi.org/10.3390/biomedicines12030514.

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Lipid metabolism is intrinsically linked to tumorigenesis. And one of the most important characteristics of cancer is the modification of lipid metabolism and its correlation with oncogenic signaling pathways within the tumors. Because lipids function as signaling molecules, membrane structures, and energy sources, lipids are essential to the development of cancer. Above all, the proper immune response of tumor cells depends on the control of lipid metabolism. Changes in metabolism can modify systems that regulate carcinogenesis, such as inflammation, oxidative stress, and angiogenesis. The de

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Ediriweera, Meran Keshawa, Jeong Yong Moon, Yen Thi-Kim Nguyen, and Somi Kim Cho. "10-Gingerol Targets Lipid Rafts Associated PI3K/Akt Signaling in Radio-Resistant Triple Negative Breast Cancer Cells." Molecules 25, no. 14 (2020): 3164. http://dx.doi.org/10.3390/molecules25143164.

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10-Gingerol is a major phenolic lipid found in the rhizomes of ginger (Zingiber officinale). Being amphiphilic in nature, phenolic lipids have the ability to incorporate into cell membranes and modulate membrane properties. The purpose of the present study was to evaluate the effects of 10-gingerol on lipid raft/membrane raft modulation in radio-resistant triple negative breast cancer (MDA-MB-231/IR) cells. The effects of 10-gingerol on MDA-MB-231/IR cells’ proliferation, clonogenic growth, migration, and invasion were assayed using MTT, colony formation, cell migration, and invasion assays, r

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Cerasuolo, Michele, Irene Di Meo, Maria Chiara Auriemma, Giuseppe Paolisso, Michele Papa, and Maria Rosaria Rizzo. "Exploring the Dynamic Changes of Brain Lipids, Lipid Rafts, and Lipid Droplets in Aging and Alzheimer’s Disease." Biomolecules 14, no. 11 (2024): 1362. http://dx.doi.org/10.3390/biom14111362.

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Aging induces complex changes in the lipid profiles across different areas of the brain. These changes can affect the function of brain cells and may contribute to neurodegenerative diseases such as Alzheimer’s disease. Research shows that while the overall lipid profile in the human brain remains quite steady throughout adulthood, specific changes occur with age, especially after the age of 50. These changes include a slow decline in total lipid content and shifts in the composition of fatty acids, particularly in glycerophospholipids and cholesterol levels, which can vary depending on the br

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Yang, Wenlin, Nikee Awasthee, Qi Chen, Seth Hale, and Daiqing Liao. "Abstract 4451: Regulation of lipid metabolism and ferroptosis by DAXX." Cancer Research 84, no. 6_Supplement (2024): 4451. http://dx.doi.org/10.1158/1538-7445.am2024-4451.

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Abstract Intracellular lipid production in cancer cells supplies lipids to synthesize cell membranes and signaling molecules during rapid cell proliferation and tumor growth. Cancer cells also utilize fatty acid oxidation (FAO) to generate ATP to meet their energy demand. Notably, lipid metabolites can inhibit and trigger ferroptosis due to iron-dependent oxidation of polyunsaturated fatty acids (PUFAs). Therefore, identifying regulators that maintain the intricate balance of lipid biosynthesis required for cell proliferation and survival is critical in cancer biology and therapy. Lipid metabo

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Liu, Zhenjiang, Lu Gan, Xiaobo Yang, Zhenzhen Zhang, and Chao Sun. "Hydrodynamic tail vein injection of SOCS3 eukaryotic expression vector in vivo promoted liver lipid metabolism and hepatocyte apoptosis in mouse." Biochemistry and Cell Biology 92, no. 2 (2014): 119–25. http://dx.doi.org/10.1139/bcb-2013-0117.

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Suppressor of cytokine signaling 3 (SOCS3), a signal transduction cytokine, is involved in lipid metabolism as well as in cell proliferation, differentiation, apoptosis, and so on. To explore the effects of SOCS3 on apoptosis and lipid metabolism in liver, we used a simple effective method named hydrodynamic tail vein injection to overexpress SOCS3. Then orbital blood was obtained for the assessment of blood lipid after injection. Lipid metabolism related genes were detected by Western blot after the determination of serum lipids. Meanwhile, liver cell apoptosis was observed by Hoechst and TUN

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Havranek, Katherine E., Judith Mary Reyes Ballista, Kelly Marie Hines, and Melinda Ann Brindley. "Untargeted Lipidomics of Vesicular Stomatitis Virus-Infected Cells and Viral Particles." Viruses 14, no. 1 (2021): 3. http://dx.doi.org/10.3390/v14010003.

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The viral lifecycle is critically dependent upon host lipids. Enveloped viral entry requires fusion between viral and cellular membranes. Once an infection has occurred, viruses may rely on host lipids for replication and egress. Upon exit, enveloped viruses derive their lipid bilayer from host membranes during the budding process. Furthermore, host lipid metabolism and signaling are often hijacked to facilitate viral replication. We employed an untargeted HILIC-IM-MS lipidomics approach and identified host lipid species that were significantly altered during vesicular stomatitis virus (VSV) i

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Bastonini, Emanuela, Daniela Kovacs, Vittoria Maresca, et al. "Lipidome Complexity in Physiological and Pathological Skin Pigmentation." International Journal of Molecular Sciences 26, no. 14 (2025): 6785. https://doi.org/10.3390/ijms26146785.

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Skin pigmentation results from complex cellular interactions and is influenced by genetic, environmental, and metabolic factors. Emerging evidence highlights the multiple pathways by which lipids regulate melanogenesis and points to lipid metabolism and signaling as key players in this process. Lipidomics is a high-throughput omics approach that enables detailed characterization of lipid profiles, thus representing a valid tool for evaluating skin lipid functional role in both physiological melanogenesis and pigmentary disorders. The use of lipidomics to gain a deeper comprehension of the role

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Torres, Manuel, Catalina Ana Rosselló, Paula Fernández-García, Victoria Lladó, Or Kakhlon, and Pablo Vicente Escribá. "The Implications for Cells of the Lipid Switches Driven by Protein–Membrane Interactions and the Development of Membrane Lipid Therapy." International Journal of Molecular Sciences 21, no. 7 (2020): 2322. http://dx.doi.org/10.3390/ijms21072322.

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The cell membrane contains a variety of receptors that interact with signaling molecules. However, agonist–receptor interactions not always activate a signaling cascade. Amphitropic membrane proteins are required for signal propagation upon ligand-induced receptor activation. These proteins localize to the plasma membrane or internal compartments; however, they are only activated by ligand-receptor complexes when both come into physical contact in membranes. These interactions enable signal propagation. Thus, signals may not propagate into the cell if peripheral proteins do not co-localize wit

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Conrard and Tyteca. "Regulation of Membrane Calcium Transport Proteins by the Surrounding Lipid Environment." Biomolecules 9, no. 10 (2019): 513. http://dx.doi.org/10.3390/biom9100513.

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Calcium ions (Ca2+) are major messengers in cell signaling, impacting nearly every aspect of cellular life. Those signals are generated within a wide spatial and temporal range through a large variety of Ca2+ channels, pumps, and exchangers. More and more evidences suggest that Ca2+ exchanges are regulated by their surrounding lipid environment. In this review, we point out the technical challenges that are currently being overcome and those that still need to be defeated to analyze the Ca2+ transport protein–lipid interactions. We then provide evidences for the modulation of Ca2+ transport pr

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Cannon, Ashley E., and Kent D. Chapman. "Lipid Signaling through G Proteins." Trends in Plant Science 26, no. 7 (2021): 720–28. http://dx.doi.org/10.1016/j.tplants.2020.12.012.

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Rhome, Ryan, and Maurizio Del Poeta. "Lipid Signaling in Pathogenic Fungi." Annual Review of Microbiology 63, no. 1 (2009): 119–31. http://dx.doi.org/10.1146/annurev.micro.091208.073431.

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Brindley, David N., and Carlos Pilquil. "Lipid phosphate phosphatases and signaling." Journal of Lipid Research 50, Supplement (2008): S225—S230. http://dx.doi.org/10.1194/jlr.r800055-jlr200.

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Tamiya-Koizumi, K. "Nuclear Lipid Metabolism and Signaling." Journal of Biochemistry 132, no. 1 (2002): 13–22. http://dx.doi.org/10.1093/oxfordjournals.jbchem.a003190.

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Pozo, Miguel A. Del. "Integrin Signaling and Lipid Rafts." Cell Cycle 3, no. 6 (2004): 723–26. http://dx.doi.org/10.4161/cc.3.6.952.

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Li, Pin-Lan, and Erich Gulbins. "Lipid Rafts and Redox Signaling." Antioxidants & Redox Signaling 9, no. 9 (2007): 1411–16. http://dx.doi.org/10.1089/ars.2007.1736.

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Sang, Nan, and Chu Chen. "Lipid Signaling and Synaptic Plasticity." Neuroscientist 12, no. 5 (2006): 425–34. http://dx.doi.org/10.1177/1073858406290794.

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Shukla, Shivendra D., Grace Y. Sun, W. Gibson Wood, Markku J. Savolainen, Christer Alling, and Jan B. Hoek. "Ethanol and Lipid Metabolic Signaling." Alcoholism: Clinical and Experimental Research 25, s1 (2001): 33S—39S. http://dx.doi.org/10.1111/j.1530-0277.2001.tb02370.x.

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Wang, Haibin, and Sudhansu K. Dey. "Lipid signaling in embryo implantation." Prostaglandins & Other Lipid Mediators 77, no. 1-4 (2005): 84–102. http://dx.doi.org/10.1016/j.prostaglandins.2004.09.013.

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Avraham-Davidi, Inbal, Moshe Grunspan, and Karina Yaniv. "Lipid signaling in the endothelium." Experimental Cell Research 319, no. 9 (2013): 1298–305. http://dx.doi.org/10.1016/j.yexcr.2013.01.009.

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Shea, John M., and Maurizio Del Poeta. "Lipid signaling in pathogenic fungi." Current Opinion in Microbiology 9, no. 4 (2006): 352–58. http://dx.doi.org/10.1016/j.mib.2006.06.003.

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Zhang, Yang, Katrin Anne Becker, and Erich Gulbins. "Lipid rafts and redox signaling." Chemistry and Physics of Lipids 160 (August 2009): S2—S3. http://dx.doi.org/10.1016/j.chemphyslip.2009.06.094.

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