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Journal articles on the topic 'Signaling nanoplatforms'

Author: Grafiati

Published: 30 November 2024

Last updated: 31 July 2025

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1

Cambi, A., M. Lakadamyali, D. S. Lidke, and M. F. Garcia-Parajo. "Meeting Report - Visualizing signaling nanoplatforms at a higher spatiotemporal resolution." Journal of Cell Science 126, no. 17 (2013): 3817–21. http://dx.doi.org/10.1242/jcs.137901.

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Kim, Hyosuk, Eun Hye Kim, Gijung Kwak, Sung-Gil Chi, Sun Hwa Kim, and Yoosoo Yang. "Exosomes: Cell-Derived Nanoplatforms for the Delivery of Cancer Therapeutics." International Journal of Molecular Sciences 22, no. 1 (2020): 14. http://dx.doi.org/10.3390/ijms22010014.

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Exosomes are cell-secreted nanovesicles that naturally contain biomolecular cargoes such as lipids, proteins, and nucleic acids. Exosomes mediate intercellular communication, enabling the transfer biological signals from the donor cells to the recipient cells. Recently, exosomes are emerging as promising drug delivery vehicles due to their strong stability in blood circulation, high biocompatibility, low immunogenicity, and natural targeting ability. In particular, exosomes derived from specific types of cells can carry endogenous signaling molecules with therapeutic potential for cancer treat

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Rahbar Saadat, Yalda, and Jaleh Barar. "Exosomes as versatile nanoscaled biocompartments in cancer therapy and/or resistance." BioImpacts 12, no. 2 (2022): 87–88. http://dx.doi.org/10.34172/bi.2022.24253.

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Cancer remains to be a major hurdle to global health. Exosomes as a versatile bio-derived platform, hold a bright prospect in nano-scaled delivery/targeting strategies. Shreds of evidence indicate that exosomes have a critical role in drug resistance in cancer cells through various mechanisms including shuttling of miRNAs, drug efflux transporters, and anti-apoptotic signaling. Exosomes’ cargo, particularly miRNAs, may exert both resistance and in a few cases sensitivity to the anticancer agents in targeted cells. Therefore, the source and components of the exosomes should be carefully conside

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Tang, Yongquan, Yan Chen, Zhe Zhang, Bo Tang, Zongguang Zhou, and Haining Chen. "Nanoparticle-Based RNAi Therapeutics Targeting Cancer Stem Cells: Update and Prospective." Pharmaceutics 13, no. 12 (2021): 2116. http://dx.doi.org/10.3390/pharmaceutics13122116.

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Cancer stem cells (CSCs) are characterized by intrinsic self-renewal and tumorigenic properties, and play important roles in tumor initiation, progression, and resistance to diverse forms of anticancer therapy. Accordingly, targeting signaling pathways that are critical for CSC maintenance and biofunctions, including the Wnt, Notch, Hippo, and Hedgehog signaling cascades, remains a promising therapeutic strategy in multiple cancer types. Furthermore, advances in various cancer omics approaches have largely increased our knowledge of the molecular basis of CSCs, and provided numerous novel targ

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Hattab, Dima, and Athirah Bakhtiar. "Bioengineered siRNA-Based Nanoplatforms Targeting Molecular Signaling Pathways for the Treatment of Triple Negative Breast Cancer: Preclinical and Clinical Advancements." Pharmaceutics 12, no. 10 (2020): 929. http://dx.doi.org/10.3390/pharmaceutics12100929.

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Triple negative breast cancer (TNBC) is one of the most aggressive types of breast cancer. Owing to the absenteeism of hormonal receptors expressed at the cancerous breast cells, hormonal therapies and other medications targeting human epidermal growth factor receptor 2 (HER2) are ineffective in TNBC patients, making traditional chemotherapeutic agents the only current appropriate regimen. Patients’ predisposition to relapse and metastasis, chemotherapeutics’ cytotoxicity and resistance and poor prognosis of TNBC necessitates researchers to investigate different novel-targeted therapeutics. Th

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Tavakol, Ashrafizadeh, Deng, et al. "Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems." Biomolecules 9, no. 10 (2019): 530. http://dx.doi.org/10.3390/biom9100530.

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Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step in designing an effective therapeutic approach is to understand the correct and accurate causes of diseases and to understand whether autophagy plays a cytoprotective or cytotoxic/cytostatic role in the progression and prevention of disease. This knowledge will help scientists find approaches to manipulate tumor and pathologic cells in order to enhance cellular sensitivity to therapeutics and treat them. Although some conventional t

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Serda, Maciej, Katarzyna Malarz, Julia Korzuch, et al. "The Water-Soluble Fullerene Nanomaterials for Pancreatic Cancer Treatment." ECS Meeting Abstracts MA2025-01, no. 11 (2025): 961. https://doi.org/10.1149/ma2025-0111961mtgabs.

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Pancreatic ductal adenocarcinoma (PDAC) is an exceedingly aggressive malignancy characterized by poor prognosis and a five-year survival rate below 5%. Conventional gemcitabine-based chemotherapy remains largely ineffective, and despite intensive efforts to develop novel therapeutics—including nanomedicines, immunotherapies, and gene-based approaches—no truly efficient treatment strategy has yet emerged. In this work, we developed a series of fullerene-based nanoplatforms designed for both the treatment and diagnosis of pancreatic tumors. As a first approach, we focused on modifying standard c

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Bracamonte, Angel Guillermo. "Current Advances in Nanotechnology for the Next Generation of Sequencing (NGS)." Biosensors 13, no. 2 (2023): 260. http://dx.doi.org/10.3390/bios13020260.

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This communication aims at discussing strategies based on developments from nanotechnology focused on the next generation of sequencing (NGS). In this regard, it should be noted that even in the advanced current situation of many techniques and methods accompanied with developments of technology, there are still existing challenges and needs focused on real samples and low concentrations of genomic materials. The approaches discussed/described adopt spectroscopical techniques and new optical setups. PCR bases are introduced to understand the role of non-covalent interactions by discussing abou

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Darie, Costel C., Angiolina Hukovic, Veronica D. Maynard, and Anca-Narcisa Neagu. "Roles of oxygen in the tumorigenesis, progression, and treatment of breast cancer." Medical Gas Research 16, no. 1 (2025): 41–45. https://doi.org/10.4103/mgr.medgasres-d-25-00023.

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Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death among women worldwide. Poor prognosis in breast cancer patients is often linked to the presence of intratumoral hypoxic areas caused by abnormal vascularization and insufficient oxygen availability, which results in energetic crisis in cancer cells; metabolic and epigenetic reprogramming; the transcription of genes involved in angiogenesis; cancer cell proliferation; increased motility, aggressiveness and metastasis; the accumulation of mutations; genomic instability; the maintenance of stem cell c

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Liang, Xinqiang, Mekhrdod S. Kurboniyon, Yuanhan Zou, et al. "GSH-Triggered/Photothermal-Enhanced H2S Signaling Molecule Release for Gas Therapy." Pharmaceutics 15, no. 10 (2023): 2443. http://dx.doi.org/10.3390/pharmaceutics15102443.

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Traditional treatment methods for tumors are inefficient and have severe side effects. At present, new therapeutic methods such as phototherapy, chemodynamic therapy, and gasodynamic therapy have been innovatively developed. High concentrations of hydrogen sulfide (H2S) gas exhibit cancer-suppressive effects. Herein, a Prussian blue-loaded tetra-sulfide modified dendritic mesoporous organosilica (PB@DMOS) was rationally constructed with glutathione (GSH)-triggered/photothermal-enhanced H2S signaling molecule release properties for gas therapy. The as-synthesized nanoplatform confined PB nanopa

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Pennisi, Rosamaria, Maria Musarra-Pizzo, Tania Velletri, et al. "Cancer-Related Intracellular Signalling Pathways Activated by DOXorubicin/Cyclodextrin-Graphene-Based Nanomaterials." Biomolecules 12, no. 1 (2022): 63. http://dx.doi.org/10.3390/biom12010063.

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In the last decade, nanotechnological progress has generated new opportunities to improve the safety and efficacy of conventional anticancer therapies. Compared with other carriers, graphene nanoplatforms possess numerous tunable functionalities for the loading of multiple bioactive compounds, although their biocompatibility is still a debated concern. Recently, we have investigated the modulation of genes involved in cancer-associated canonical pathways induced by graphene engineered with cyclodextrins (GCD). Here, we investigated the GCD impact on cells safety, the HEp-2 responsiveness to Do

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Yan, Huimin, Ying Hu, Antonina Akk, et al. "Induction of WNT16 via Peptide-mRNA Nanoparticle-Based Delivery Maintains Cartilage Homeostasis." Pharmaceutics 12, no. 1 (2020): 73. http://dx.doi.org/10.3390/pharmaceutics12010073.

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Osteoarthritis (OA) is a progressive joint disease that causes significant disability and pain and for which there are limited treatment options. We posit that delivery of anabolic factors that protect and maintain cartilage homeostasis will halt or retard OA progression. We employ a peptide-based nanoplatform to deliver Wingless and the name Int-1 (WNT) 16 messenger RNA (mRNA) to human cartilage explants. The peptide forms a self-assembled nanocomplex of approximately 65 nm in size when incubated with WNT16 mRNA. The complex is further stabilized with hyaluronic acid (HA) for enhanced cellula

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Wang, Yin, Fanyu Wu, Tan Yang, et al. "Dual-Action Tocilizumab-Conjugated Cisplatin Nanoparticles Overcome Chemoresistance and Metastasis in Non-Small-Cell Lung Cancer." Pharmaceutics 17, no. 7 (2025): 945. https://doi.org/10.3390/pharmaceutics17070945.

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Background/Objectives: Cisplatin remains a cornerstone chemotherapeutic agent for non-small-cell lung cancer (NSCLC) treatment, yet its clinical utility is substantially limited by acquired resistance and the inadequate suppression of tumor metastasis. Emerging evidence implicates interleukin 6 (IL-6) as a critical mediator of chemoresistance through cancer stem cell (CSC) enrichment and metastasis promotion via epithelial–mesenchymal transition (EMT) induction, ultimately contributing to cisplatin therapy failure. This study sought to address these challenges by designing a nanoplatform with

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Balaure, Paul Cătălin, and Alexandru Mihai Grumezescu. "Recent Advances in Surface Nanoengineering for Biofilm Prevention and Control. Part I: Molecular Basis of Biofilm Recalcitrance. Passive Anti-Biofouling Nanocoatings." Nanomaterials 10, no. 6 (2020): 1230. http://dx.doi.org/10.3390/nano10061230.

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Medical device-associated infections are becoming a leading cause of morbidity and mortality worldwide, prompting researchers to find new, more effective ways to control the bacterial colonisation of surfaces and biofilm development. Bacteria in biofilms exhibit a set of “emergent properties”, meaning those properties that are not predictable from the study of free-living bacterial cells. The social coordinated behaviour in the biofilm lifestyle involves intricate signaling pathways and molecular mechanisms underlying the gain in resistance and tolerance (recalcitrance) towards antimicrobial a

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Yao, Ke, Xin Liang, Guiyang Zhang, et al. "Covalent Organic Framework (COF): A Drug and Carrier to Attenuate Retinal Ganglion Cells Death in an Acute Glaucoma Mouse Model." Polymers 14, no. 16 (2022): 3265. http://dx.doi.org/10.3390/polym14163265.

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Purpose: We aim to investigate the use of covalent organic framework (COF) nanoparticles in the local treatment of glaucoma, both as a means of protecting retinal ganglion cells (RGCs), and as a carrier for delayed release of the medication rapamycin following a single intravitreal injection. Methods: a water-dispersible COF, and a COF-based nanoplatform for rapamycin release (COF-Rapa) was constructed. C57BL/6J mice were randomly divided into four groups: intravitreal injection of 1.5 µL normal saline (NS), COF (0.67 ng/µL), rapamycin (300 µM) or COF-Rapa (0.67 ng/µL-300 µM), respectively. Th

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Lei, Kai, Ruihao Liang, Jialu Liang, et al. "CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1." Journal of Experimental & Clinical Cancer Research 43, no. 1 (2024). http://dx.doi.org/10.1186/s13046-024-03054-3.

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Abstract Background Esophageal squamous cell carcinoma (ESCC) is a common gastrointestinal tumor and has become an important global health problem. The PI3K/AKT signaling pathway plays a key role in the development of ESCC. CircRNAs have been reported to be involved in the regulation of the PI3K/AKT pathway, but the underlying mechanisms are unclear. Therefore, this study aimed to identify protein-coding circRNAs and investigate their functions in ESCC. Methods Differential expression of circRNAs between ESCC tissues and adjacent normal tissues was identified using circRNA microarray analysis.

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Tu, Zhaoxu, Ming Liu, Changyi Xu, et al. "Functional 2D Nanoplatforms Alleviate Eosinophilic Chronic Rhinosinusitis by Modulating Eosinophil Extracellular Trap Formation." Advanced Science, March 13, 2024. http://dx.doi.org/10.1002/advs.202307800.

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AbstractThe therapeutic outcomes of patients with eosinophilic chronic rhinosinusitis (ECRS) remain unsatisfactory, largely because the underlying mechanisms of eosinophilic inflammation are uncertain. Here, it is shown that the nasal secretions of ECRS patients have high eosinophil extracellular trap (EET) and cell‐free DNA (cfDNA) levels. Moreover, the cfDNA induced EET formation by activating toll‐like receptor 9 (TLR9) signaling. After demonstrating that DNase I reduced eosinophilic inflammation by modulating EET formation, linear polyglycerol‐amine (LPGA)‐coated TiS2 nanosheets (TLPGA) as

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Xu, Shuaishuai, Huaxiang Xu, Wenquan Wang, et al. "The role of collagen in cancer: from bench to bedside." Journal of Translational Medicine 17, no. 1 (2019). http://dx.doi.org/10.1186/s12967-019-2058-1.

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Abstract Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes, transcription factors, signaling pathways and receptors; furthermore, collagen can influence tumor cell behavior through integrins, discoidin domain receptors, tyrosine kinase receptors, and some signaling pathways. Exosomes and microRNAs are closely associated with collagen in cancer. Hypoxia, which is common in collagen-rich conditions, intensifies cancer progression, and other substances in the extracellular

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Bracamonte, A. Guillermo. "Nano-Engineering Versatile Core-Shell Nanoplatforms for Tuning Enhanced Opto-electronic Matter Interactions." Journal of Optics and Photonics Research, April 23, 2025. https://doi.org/10.47852/bonviewjopr52025116.

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In this communication, it is presented the concept of optics based on Core-shell architectures controlling the nanoscale and beyond. It is demonstrated how these types of architectures can be designed, from prototyping to synthesis, using colloidal and laser-based techniques. This particular nanoarchitecture was presented as a fundamental structure that can be tuned as needed through the use of various materials, enabling control over size, shape, and topological features. Then, the impact of Core-shell nanoarchitecture to tune photon and electron matter interactions to enhance physics and che

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Yu, Qiuyu, Yue Gao, Waicong Dai, et al. "Cell Membrane‐Camouflaged Chitosan‐Polypyrrole Nanogels Co‐Deliver Drug and Gene for Targeted Chemotherapy and Bone Metastasis Inhibition of Prostate Cancer." Advanced Healthcare Materials, April 6, 2024. http://dx.doi.org/10.1002/adhm.202400114.

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AbstractThe development of functional nanoplatforms to improve the chemotherapy outcome and inhibit distal cancer cell metastasis remains an extreme challenge in cancer management. In this work, we report a human‐derived PC‐3 cancer cell membrane‐camouflaged chitosan‐polypyrrole nanogel (CH‐PPy NG) platform, which can be loaded with chemotherapeutic drug docetaxel (DTX) and RANK siRNA for targeted chemotherapy and gene silencing‐mediated metastasis inhibition of late‐stage prostate cancer in a mouse model. The prepared NGs with a size of 155.8 nm show good biocompatibility, pH‐responsive drug

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Xu, Shibo, Linna Chang, Yanan Hu, et al. "Tea polyphenol modified, photothermal responsive and ROS generative black phosphorus quantum dots as nanoplatforms for promoting MRSA infected wounds healing in diabetic rats." Journal of Nanobiotechnology 19, no. 1 (2021). http://dx.doi.org/10.1186/s12951-021-01106-w.

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Abstract Background Healing of MRSA (methicillin-resistant Staphylococcus aureus) infected deep burn wounds (MIDBW) in diabetic patients remains an obstacle but is a cutting-edge research problem in clinical science. Surgical debridement and continuous antibiotic use remain the primary clinical treatment for MIDBW. However, suboptimal pharmacokinetics and high doses of antibiotics often cause serious side effects such as fatal complications of drug-resistant bacterial infections. MRSA, which causes wound infection, is currently a bacterium of concern in diabetic wound healing. In more severe c

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Chen, Xi, Zhijie Xu, Tongfei Li, et al. "Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy." Biomarker Research 12, no. 1 (2024). http://dx.doi.org/10.1186/s40364-023-00551-z.

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AbstractThe cGAS-STING signaling pathway has emerged as a critical mediator of innate immune responses, playing a crucial role in improving antitumor immunity through immune effector responses. Targeting the cGAS-STING pathway holds promise for overcoming immunosuppressive tumor microenvironments (TME) and promoting effective tumor elimination. However, systemic administration of current STING agonists faces challenges related to low bioavailability and potential adverse effects, thus limiting their clinical applicability. Recently, nanotechnology-based strategies have been developed to modula

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Feng, Yanlin, Jianlin Wang, Jimin Cao, Fangfang Cao, and Xiaoyuan Chen. "Manipulating calcium homeostasis with nanoplatforms for enhanced cancer therapy." Exploration, October 10, 2023. http://dx.doi.org/10.1002/exp.20230019.

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AbstractCalcium ions (Ca2+) are indispensable and versatile metal ions that play a pivotal role in regulating cell metabolism, encompassing cell survival, proliferation, migration, and gene expression. Aberrant Ca2+ levels are frequently linked to cell dysfunction and a variety of pathological conditions. Therefore, it is essential to maintain Ca2+ homeostasis to coordinate body function. Disrupting the balance of Ca2+ levels has emerged as a potential therapeutic strategy for various diseases, and there has been extensive research on integrating this approach into nanoplatforms. In this revie

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Bracamonte, A. Guillermo. "Hybrid Nano-platforms, and Silica Nano-hole Particles Intended for Enhanced Energy Modes: Light Scattering Studies Towards Lasers Developments." Journal of Optics and Photonics Research, February 29, 2024. http://dx.doi.org/10.47852/bonviewjopr42022233.

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In this short review, it was communicated about the design and synthesis of optical active nanoplatforms for Light Scattering studies highlighting holed nanoarchitectures as main sources of potential additional resonances and enhanced phenomena. In this context, the nanoplatforms were based on varied materials such as silicon compounds, silica, modified organosilanes, Nobel metals, and organic materials as well; such molecular and polymeric spacers, chromophores, etc. By this manner it was discussed how it could be recorded Enhanced Light Scattering signalling from hybrid nanoplatforms and nan

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Li, Zimu, Zirui Chen, Kexin Shi, et al. "Polyphenol‐Based Self‐Assembled Nanomedicine for a Three‐Pronged Approach to Reversing Tumor Immunosuppression." Advanced Healthcare Materials, September 29, 2024. http://dx.doi.org/10.1002/adhm.202402127.

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AbstractThe challenges of multi‐pathway immune resistance and systemic toxicity caused by the direct injection of immune checkpoint inhibitors are critical factors that compromise the effectiveness of clinical immune checkpoint blockade therapy. In this context, natural polyphenols have been employed as the primary component to construct a targeted and acid‐responsive PD‐L1 antibody (αPD‐L1) delivery nanoplatform. This platform incorporates garcinol, an inhibitor of the Nuclear Factor Kappa‐B (NF‐κB) signaling pathway, to regulate pro‐tumor immune escape cytokines and regulatory T cells. Addit

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Jing, Yuan-Zhe, Shu-Jin Li, and Zhi-Jun Sun. "Gas and gas-generating nanoplatforms in cancer therapy." Journal of Materials Chemistry B, 2021. http://dx.doi.org/10.1039/d1tb01661j.

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Wang, Shuangling, Yalin Wang, Jie Lv, et al. "Remote Manipulation of TRPV1 Signaling by Near‐Infrared Light‐Triggered Nitric Oxide Nanogenerators for Specific Cancer Therapy." Advanced Healthcare Materials, December 28, 2023. http://dx.doi.org/10.1002/adhm.202303579.

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AbstractSpecific activation of transient receptor potential vanilloid member 1 (TRPV1) channels provides a new avenue for cancer treatment by inducing excessive Ca2+ influx. However, controllable manipulation of TRPV1 signaling for clinical application has remained elusive due to the challenge in finding a mild and effective method of exerting external stimulus without adverse side effects in living systems. Herein, a TRPV1‐targeting near‐infrared (NIR) triggered nitric oxide (NO)‐releasing nanoplatform (HCuS@PDA‐TRPV1/BNN6) based on polydopamine (PDA) coated hollow copper sulfide nanoparticle

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He, Qingbin, Runxiao Zheng, Junchi Ma, Luyang Zhao, Yafang Shi, and Jianfeng Qiu. "Responsive manganese-based nanoplatform amplifying cGAS-STING activation for immunotherapy." Biomaterials Research 27, no. 1 (2023). http://dx.doi.org/10.1186/s40824-023-00374-x.

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Abstract Background The activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) signaling pathway has attracted great attention for its ability to up-regulate innate immune response and thus enhance cancer immunotherapy. However, many STING agonists limit the further advancement of immunotherapy due to weak tumor responsiveness or low activation efficiency. The responsive and effective activation of cGAS-STING signaling in tumors is a highly challenging process. Methods In this study, a manganese-based nanoplatform (MPCZ NPs

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Fu, Jixian, Chunyu Song, Shan Jiang, et al. "Drug Delivery Platform Targeting MMP9 in Combination with Photothermal Therapy to Improve Tumor Chemosensitivity." Advanced Healthcare Materials, April 22, 2025. https://doi.org/10.1002/adhm.202500174.

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AbstractTumor chemotherapy insensitivity poses a significant challenge in cancer treatment, with angiogenesis being a key contributing factor. Angiogenesis supplies oxygen and nutrients to tumor cells, thereby impairing treatment outcomes. Based on these findings, an MMP9‐responsive carbon quantum dot‐based nanoplatform (MMP9i@MTX@CQDs) encapsulating methotrexate (MTX) and an MMP9 inhibitor (MMP9i) is developed to overcome chemotherapy insensitivity. Targeting the high expression of MMP9 in tumors, the platform releases its payload in a responsive manner. Under near‐infrared (NIR) irradiation,

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Yue, Ziqi, Yichen Yang, Lulingxiao Nie, et al. "A Binary siRNA‐Loaded Tetrahedral DNA Nanobox for Synergetic Anti‐Aging Therapy." Small, December 17, 2024. https://doi.org/10.1002/smll.202408323.

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AbstractExtensive accumulation of senescent cells contributes to organismal aging, and slowing down the process of cellular senescence may ameliorate age‐related pathologies. Targeted inhibition of the mechanistic target of rapamycin complex 1 (mTORC1) is found to suppress the conversion of cells to senescence. The regulatory‐associated protein of mTOR (Raptor), a key component of mTORC1, has been implicated as important in the aging process, and its druggability deserves to be investigated. Due to high efficiency and high convenience in drug construction, siRNA shows great potential in silenc

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Jia, Qi, Yijuan Ding, Ziwen Su, et al. "Cell membrane-camouflaged nanoparticles activate fibroblast-myofibroblast transition to promote skin wound healing." Biofabrication, December 10, 2024. https://doi.org/10.1088/1758-5090/ad9cc4.

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Abstract The fibroblast-myofibroblast transition marked by extracellular matrix (ECM) secretion and contraction of actomyosin-based stress fibers, plays central roles in the wound healing process. This work aims to utilize a cell membrane-based nanoplatform to improve the outcomes of dysregulated wound healing. The cell membranes of myofibroblasts are isolated from mouse skin, and used as a camouflage to encapsulate gold nanoparticles with an adjuvant cytokine of IL-4. The membrane-camouflaged nanoparticles show effective in situ clearance of bacterial infection, and act as an activator in IL-

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Cui, Jin, Gongzheng Wang, Li Xian Yip, et al. "Enhanced Ferritin‐Manganese Interaction by Nanoplatinum Growth Enabling Liver Fibrosis 3D Magnetic Resonance Visualization and Synergistic Therapy with Real‐Time Monitoring." Advanced Functional Materials 34, no. 52 (2024). https://doi.org/10.1002/adfm.202410748.

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AbstractEarly detection and timely intervention are essential to prevent liver fibrosis from progressing to cirrhosis or hepatocellular carcinoma. Herein, utilizing the enhanced ferritin‐manganese interaction by nanoplatinum growth, a novel ferritin‐platinum‐manganese magnetic resonance nanoplatform with RGD grafting and metformin loading (FNMMR) is developed. RGD can enhance the targeting ability of the nanoplatform toward integrin αVβ3 on activated hepatic stellate cells (aHSCs) in liver fibrosis. Systemic delivery of FNMMR shows clear degree‐dependent magnetic resonance contrast enhancement

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Weng, Zhenzhen, Jing Ye, Changxiong Cai, et al. "Inflammatory microenvironment regulation and osteogenesis promotion by bone-targeting calcium and magnesium repletion nanoplatform for osteoporosis therapy." Journal of Nanobiotechnology 22, no. 1 (2024). http://dx.doi.org/10.1186/s12951-024-02581-7.

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AbstractOsteoporosis is the most common bone metabolic disease that affects the health of middle-aged and elderly people, which is hallmarked by imbalanced bone remodeling and a deteriorating immune microenvironment. Magnesium and calcium are pivotal matrix components that participate in the bone formation process, especially in the immune microenvironment regulation and bone remodeling stages. Nevertheless, how to potently deliver magnesium and calcium to bone tissue remains a challenge. Here, we have constructed a multifunctional nanoplatform composed of calcium-based upconversion nanopartic

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Lin, Jia‐Yi, Ye Wu, Xiao‐Hui Liang, et al. "A Self‐Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple‐Negative Breast Cancer Therapy." Advanced Science, May 11, 2025. https://doi.org/10.1002/advs.202500311.

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AbstractAs a multifunctional extracellular protein, connective tissue growth factor (CTGF/CCN2) is significantly associated with the progression and prognosis of triple‐negative breast cancer (TNBC). However, current blockade therapies targeting CTGF's multiple domains are limited, creating substantial challenges in treatment. Lysosome‐targeting chimeras (LYTACs) have emerged as a promising approach for achieving complete protein degradation and inhibiting CTGF's various bioactivities. In this study, a self‐assembling LYTAC nanoplatform, NanoCLY, designed to tumor microenvironment (TME)‐respon

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Liu, Yingying, Zhiyan Ma, Xin Wang, et al. "A Core‐Brush Nanoplatform with Enhanced Lubrication and Anti‐Inflammatory Properties for Osteoarthritis Treatment." Advanced Science, November 2024. http://dx.doi.org/10.1002/advs.202406027.

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AbstractOsteoarthritis (OA) is recognized as a highly friction‐related joint disease primarily associated with increased joint friction and inflammation due to pro‐inflammatory M1‐type macrophage infiltration in the articular cavity. Therefore, strategies to simultaneously increase lubrication and relieve inflammation to remodel the damaged articular microenvironment are of great significance for enhancing its treatment. Herein, a multifunctional core‐brush nanoplatform composed of a ROS‐scavenging polydopamine‐coated SiO2 core and lubrication‐enhancing zwitterionic poly(2‐methacryloyloxyethyl

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Hu, Jiateng, Zhijue Xu, Donghui Liao, et al. "An H₂S‐BMP6 Dual‐Loading System with Regulating Yap/Taz and Jun Pathway for Synergistic Critical Limb Ischemia Salvaging Therapy." Advanced Healthcare Materials, August 3, 2023. http://dx.doi.org/10.1002/adhm.202301316.

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AbstractCritical limb ischemia, the final course of peripheral artery disease, is characterized by an insufficient supply of blood flow and excessive oxidative stress. H2S molecular therapy possesses huge potential for accelerating revascularization and scavenging intracellular reactive oxygen species (ROS). Moreover, it is found that BMP6 is the most significantly up‐expressed secreted protein‐related gene in HUVECs treated with GYY4137, a H2S donor, based on the transcriptome analysis. Herein, a UIO‐66‐NH2@GYY4137@BMP6 co‐delivery nanoplatform to strengthen the therapeutic effects of limb is

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Pan, Xiaoyu, Yan Lin, Chunlin Lin, et al. "Enhanced cGAS‐STING Activation and Immune Response by LPDAM Platform‐Based Lapachone–Chemical–Photothermal Synergistic Therapy for Colorectal Cancer." Advanced Healthcare Materials, March 19, 2025. https://doi.org/10.1002/adhm.202403309.

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AbstractThe cGAS‐STING signaling pathway is a pivotal immune response mechanism that bridges tumor and immune cell interactions. This study describes a multifunctional LPDAM nanoplatform integrating Lapachone, polydopamine (PDA), and Mn2+, which synergistically kills tumor cells and activates the cGAS‐STING pathway, thereby inducing DC maturation and T cell activation to achieve potent antitumor immunity. In the tumor microenvironment, Lapachone generates H2O2 via the NAD(P)H:quinone oxidoreductase 1 (NQO1 enzyme), while Mn2+ catalyze H2O2 conversion into •OH through chemodynamic effects (CDT)

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Wang, Yang, Xueru Zhou, Li Yao, et al. "Capsaicin Enhanced the Efficacy of Photodynamic Therapy Against Osteosarcoma via a Pro‐Death Strategy by Inducing Ferroptosis and Alleviating Hypoxia." Small, January 14, 2024. http://dx.doi.org/10.1002/smll.202306916.

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AbstractFerroptosis, a novel form of nonapoptotic cell death, can effectively enhance photodynamic therapy (PDT) performance by disrupting intracellular redox homeostasis and promoting apoptosis. However, the extremely hypoxic tumor microenvironment (TME) together with highly expressed hypoxia‐inducible factor‐1α (HIF‐1α) presents a considerable challenge for clinical PDT against osteosarcoma (OS). Hence, an innovative nanoplatform that enhances antitumor PDT by inducing ferroptosis and alleviating hypoxia is fabricated. Capsaicin (CAP) is widely reported to specifically activate transient rec

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Zheng, Tao, Jie Sheng, Zhiyue Wang, et al. "Injured Myocardium‐Targeted Theranostic Nanoplatform for Multi‐Dimensional Immune‐Inflammation Regulation in Acute Myocardial Infarction." Advanced Science, January 21, 2025. https://doi.org/10.1002/advs.202414740.

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AbstractPyroptosis is a key mode of programmed cell death during the early stages following acute myocardial infarction (AMI), driving immune‐inflammatory responses. Cardiac resident macrophages (CRMs) are the primary mediators of cardiac immunity, and they serve a dual role through their shaping of both myocardial injury and post‐AMI myocardial repair. To appropriately regulate AMI‐associated inflammation, HM4oRL is herein designed, an innovative bifunctional therapeutic nanoplatform capable of inhibiting cardiomyocyte pyroptosis while reprogramming inflammatory signaling. This HM4oRL platfor

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Huang, Qili, Chendi Ding, Wenyan Wang, et al. "An “AND” logic gate–based supramolecular therapeutic nanoplatform for combatting drug-resistant non–small cell lung cancer." Science Advances 10, no. 39 (2024). http://dx.doi.org/10.1126/sciadv.adp9071.

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Despite targeted therapies like epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), non–small cell lung cancer (NSCLC) remains a clinical challenge due to drug resistance hampering their efficacy. Here, we designed an “AND” logic gate–based supramolecular therapeutic platform (HA-BPY-GEF-NPs) for the treatment of EGFR-TKI resistant NSCLC. This system integrates both internal and external stimuli–responsive mechanisms that need to be activated in a preset sequence, enabling it to precisely control drug release behavior for enhancing therapeutic precision. By programming the

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Zuo, Tiantian, Jun Zhang, Jie Yang, et al. "On-Demand responsive nanoplatform mediated targeting CAFs and down-regulating mtROS-PYK2 signaling for antitumor metastasis." Biomaterials Science, 2021. http://dx.doi.org/10.1039/d0bm01878c.

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The desmoplastic tumor microenvironment (DTME), including overexpressed stromal cells and extracellular matrix, formed the first barrier for accumulation and penetration of nanoparticles in tumors, which compromised the therapeutic efficacy and...

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Yu, Wenyan, Chengyuan Che, Yi Yang, et al. "Bioactive Self‐Assembled Nanoregulator Enhances Hematoma Resolution and Inhibits Neuroinflammation in the Treatment of Intracerebral Hemorrhage." Advanced Science, November 8, 2024. http://dx.doi.org/10.1002/advs.202408647.

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AbstractHematoma and secondary neuroinflammation continue to pose a significant challenge in the clinical treatment of intracerebral hemorrhage (ICH). This study describes a nanoregulator formed through the self‐assembly of Mg2+ and signal regulatory protein α (SIRPα) DNAzyme (SDz), aimed at enhancing hematoma resolution and inhibiting neuroinflammation in the treatment of ICH. The structure of SDz collapses in response to the acidic endo/lysosomal microenvironment of microglia, releasing Mg2+ and the SIRPα DNAzyme. The Mg2+ then acts as a cofactor to activate the SIRPα DNAzyme. By blocking th

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Feng, Xianquan, Yan Zhang, Wanjing Lin, et al. "A Self‐Amplifying Photodynamic Biomedicine for Cascade Immune Activation Against Triple‐Negative Breast Cancer." Small, January 23, 2025. https://doi.org/10.1002/smll.202410214.

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AbstractThe efficacy of immunotherapy in triple‐negative breast cancer (TNBC) is significantly hindered by its low immunogenicity and immunosuppressive tumor microenvironment. Non‐invasive photodynamic therapy (PDT) is increasingly recognized as a potential immunotherapeutic stimulant in the treatment of TNBC. However, photodynamic immunotherapy is constrained by tumor hypoxia and excessive inflammation suppression during the course of treatment. Herein, a simple and efficacious biomedicine is formulated to overcome adverse influences by amplifying photodynamic immunotherapy, thereby stimulati

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Fernandes, Donald A. "Review on Metal-Based Theranostic Nanoparticles for Cancer Therapy and Imaging." Technology in Cancer Research & Treatment 22 (January 2023). http://dx.doi.org/10.1177/15330338231191493.

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Theranostic agents are promising due to their ability to diagnose, treat and monitor different types of cancer using a variety of imaging modalities. The advantage specifically of nanoparticles is that they can accumulate easily at the tumor site due to the large gaps in blood vessels near tumors. Such high concentration of theranostic agents at the target site can lead to enhancement in both imaging and therapy. This article provides an overview of nanoparticles that have been used for cancer theranostics, and the different imaging, treatment options and signaling pathways that are important

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Liu, Junzhao, Zuohong Wu, Yadong Liu, et al. "ROS-responsive liposomes as an inhaled drug delivery nanoplatform for idiopathic pulmonary fibrosis treatment via Nrf2 signaling." Journal of Nanobiotechnology 20, no. 1 (2022). http://dx.doi.org/10.1186/s12951-022-01435-4.

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Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disease with pathophysiological characteristics of transforming growth factor-β (TGF-β), and reactive oxygen species (ROS)-induced excessive fibroblast-to-myofibroblast transition and extracellular matrix deposition. Macrophages are closely involved in the development of fibrosis. Nuclear factor erythroid 2 related factor 2 (Nrf2) is a key molecule regulating ROS and TGF-β expression. Therefore, Nrf2 signaling modulation might be a promising therapy for fibrosis. The inhalation-based drug delivery can reduce syst

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Wu, Ye, Jia‐Yi Lin, Yu‐Dong Zhou, et al. "Oncolytic Peptide‐Nanoplatform Drives Oncoimmune Response and Reverses Adenosine‐Induced Immunosuppressive Tumor Microenvironment." Advanced Healthcare Materials, January 30, 2024. http://dx.doi.org/10.1002/adhm.202303445.

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AbstractThe application of oncolytic peptides has become a powerful approach to induce complete and long‐lasting remission in multiple types of carcinomas, as affirmed by the appearance of tumor‐associated antigens and adenosine triphosphate (ATP) in large quantities, which jumpstarts the cancer‐immunity cycle. However, the ATP breakdown product adenosine is a significant contributor to forming the immunosuppressive tumor microenvironment, which substantially weakens peptide‐driven oncolytic immunotherapy. In this study, a lipid‐coated micelle (CA@TLM) loaded with a stapled oncolytic peptide (

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Li, Lin, Guangyu Rong, Xin Gao та ін. "Bone‐Targeted Fluoropeptide Nanoparticle Inhibits NF‐κB Signaling to Treat Osteosarcoma and Tumor‐Induced Bone Destruction". Advanced Science, 6 листопада 2024. http://dx.doi.org/10.1002/advs.202412014.

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AbstractOsteosarcoma is a malignant bone cancer usually characterized by symptoms of bone loss due to pathologically enhanced osteoclast activity. Activated osteoclasts enhance bone resorption and promote osteosarcoma cell progression by secreting various cytokines. Intercepting the detrimental interplay between osteoclasts and osteosarcoma cells is considered as an option for osteosarcoma treatment. Here, a bone‐targeted fluoropeptide nanoparticle that can inhibit the nuclear factor kappa B (NF‐κB) signaling in both osteoclasts and osteosarcoma to address the above issue is developed. The NF‐

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Cong, Yiyang, Bo Sun, Jianlun Hu, et al. "A carbon monoxide releasing metal organic framework nanoplatform for synergistic treatment of triple-negative breast tumors." Journal of Nanobiotechnology 20, no. 1 (2022). http://dx.doi.org/10.1186/s12951-022-01704-2.

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Abstract Background Carbon monoxide (CO) is an important signaling molecule participating in multiple biological functions. Previous studies have confirmed the valuable roles of CO in cancer therapies. If the CO concentration and distribution can be controlled in tumors, new cancer therapeutic strategy may be developed to benefit the patient survival. Results In this study, a UiO-67 type metal–organic framework (MOF) nanoplatform was produced with cobalt and ruthenium ions incorporated into its structure (Co/Ru-UiO-67). Co/Ru-UiO-67 had a size range of 70–90 nm and maintained the porous struct

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Li, Lin, Guanheng Wang, Biao Xue, et al. "A Chiral Amino Acid-Modified pH-Responsive Nanoplatform Coactivates Cuproptosis and cGAS-STING Signaling Pathways for Cancer Therapy." ACS Materials Letters, April 21, 2025, 1973–83. https://doi.org/10.1021/acsmaterialslett.5c00097.

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Xu, Zhijie, Zhiyang Zhou, Xiaoxin Yang, et al. "Determining M2 macrophages content for the anti-tumor effects of metal-organic framework-encapsulated pazopanib nanoparticles in breast cancer." Journal of Nanobiotechnology 22, no. 1 (2024). http://dx.doi.org/10.1186/s12951-024-02694-z.

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AbstractPazopanib (PAZ), an oral multi-tyrosine kinase inhibitor, demonstrates promising cytostatic activities against various human cancers. However, its clinical utility is limited by substantial side effects and therapeutic resistance. We developed a nanoplatform capable of delivering PAZ for enhanced anti-breast cancer therapy. Nanometer-sized PAZ@Fe-MOF, compared to free PAZ, demonstrated increased anti-tumor therapeutic activities in both syngeneic murine 4T1 and xenograft human MDA-MB-231 breast cancer models. High-throughput single-cell RNA sequencing (scRNAseq) revealed that PAZ@Fe-MO

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