Relevant bibliographies by topics / Signaling systems / Dissertations / Theses
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Dissertations / Theses on the topic 'Signaling systems'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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1

Avva, Jayant. "Complex Systems Biology of Mammalian Cell Cycle Signaling in Cancer." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1295625781.

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2

Gilkeson, John T. "DIGITAL SIGNALING PROCESSOR RESOURCE MANAGEMENT FOR SMALL OFFICE PHONE SYSTEMS." DigitalCommons@CalPoly, 2010. https://digitalcommons.calpoly.edu/theses/318.

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Contemporary small office phone systems are specialized computers that connect a variety of phones within the office and to the local phone company. These systems use digital signaling processors (DSPs) to convert signals from analog to digital and vice-versa. Many different types of applications run on the DSPs and different businesses have varying application needs. Given the systems have limited amounts of DSP resources and growing numbers of applications for a phone system, an administrator needs a way to configure the uses of resources based on their individual business needs. This the
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3

Taylor, Robert James. "Systems biology of cellular signaling : quantitative experimentation and systems genetics approaches." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/7101.

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Cellular regulation is governed by dense biomolecular networks consisting of proteins, nucleotides, lipids, and metabolites that dynamically coordinate cellular decision making in the face of complex and time-varying environmental stimuli. Obtaining predictive models of these complex networks is a central goal of systems biology and requires sophisticated technologies for the acquisition and integration of many disparate data types. Recent genomic, proteomic and cellular imaging developments have greatly enabled systems-level studies, but further technological advances are needed. For instance
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4

Schrier, Sarah B. "Systems analysis of cytokine mediated communication and signaling." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/104228.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 121-136).<br>Immune cells communicate with each other to mount an effective response to pathogens or maintain homeostasis. Communication and activation of the immune cell network can occur in part through secretion of or response to cytokines. Here, we couple experimental approaches with computational analysis to identify how cytokine communication impacts immune-rich cellular environments. The first part of th
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Apostolatos, Hercules S. "Splicing Systems for Studying Signaling to the Spliceosome." Scholar Commons, 2010. https://scholarcommons.usf.edu/etd/1563.

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Alternative splicing is a major contributing factor to protein diversity. The human genome project validated that there are about 25,000 genes, but over 100,000 proteins. Genes contain numerous exons that are specifically regulated; thus, elucidating alternative splicing mechanisms of pre-mRNAs is an immense undertaking. Two basic tools are used to study this mammoth task. For in vitro studies, usually in vitro transcription followed by splicing assays is used. For in vivo studies, the main technique is the construction of minigenes. These techniques enable one to study the mechanisms/conditio
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6

Marcil, Thomas Henry. "Performance measurement and signaling in the humanitarian marketplace." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/81124.

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Thesis (S.M. in Technology and Policy)--Massachusetts Institute of Technology, Engineering Systems Division, 2013.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 191-198).<br>This thesis considers ways in which humanitarian organizations can evaluate their performance internally, signal their performance to others, and what this might mean for the humanitarian relief community as a whole. Part I demonstrates an approach by which humanitarian organizations can develop key performance indicators (KPIs) to measure the performance of their logistics and supply
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7

Politi, Antonio. "Systems biology perspectives on calcium signaling and DNA repair." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2008. http://dx.doi.org/10.18452/15730.

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Der erste Teil dieser Arbeit konzentriert sich auf die Mechanismen hormoninduzierter Ca2+-oszillationen, und wie diese von Konzentrationsschwankungen des Ca2+-freisetzenden Botenstoffes Inositol-1,4,5-trisphosphat (IP3) beinflusst werden. Wir konnten zeigen, dass IP3-Oszillationen die Frequenzkodierung des äußeren Stimulus durch Ca2+-Ozillationen deutlich verstärken. Zwei Mechanismen für das Entstehen der IP3-Oszillationen wurden untersucht: es zeigte sich, dass die Aktivierung der Phospholipase C durch Ca2+ der wahrscheinlichste Mechanismus ist. Um die Rolle der IP3-Oszillationen genauer zu v
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8

Saucerman, Jeffrey J. "Systems analysis of beta-adrenergic signaling in cardiac myocytes /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3175273.

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9

Brännmark, Cecilia. "Insulin Signaling in Human Adipocytes a Systems Biology Approach." Doctoral thesis, Linköpings universitet, Cellbiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-85001.

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Obesity and a sedentary life style are associated with type 2 diabetes, a disease starting with insulin resistance in the adipose tissue, which spreads to the whole body. Despite large research efforts to understand the insulin signaling system, there is little knowledge of the mechanisms behind insulin resistance and type 2 diabetes developments. We have herein focused on the insulin signaling in adipocytes, elucidating mechanisms for early signaling. We have also modeled isolated adipocytes and data from the in vivo, whole bodysituation, concurrently. We also mapped and quantitatively descri
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10

Lubin, Emma A. (Emma Alexandra). "Mechanism and specificity of bacterial two-component signaling systems." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/57799.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Biology, 2010.<br>Includes bibliographical references (p. 57-60).<br>Bacterial two component signaling (TCS) systems are the predominant means by which bacteria sense and respond to external signals. These systems represent a large family of paralogous proteins; often hundreds of the histidine kinase (HK) and response regulator (RR) pairs that make up a TCS system can be found in a single cell. How do these systems maintain faithful signal transmission and avoid cross-talk? To understand how specificity is determined, we examined c
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11

Ulfhielm, Erik. "Modeling of metabolic insulin signaling in adipocytes." Thesis, Linköping University, Department of Electrical Engineering, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-6520.

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<p>Active insulin receptors (IR) phosphorylate insulin receptor substrate (IRS), but it is not clear whether IRS is phosphorylated mainly by IR at the plasma membrane or by internalized IR in the cytosol. In this thesis, structural identifiability analysis and parameter sensitivity analysis is performed for models of the first steps in the metabolic insulin signaling pathway. In particular, the identifiability of the kinetic parameters governing IRS phosphorylation are investigated.</p><p>Given measurements of the relative increase in phosphorylation degree of IR and IRS, the structural ident
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12

Rajamani, Sathish. "Small molecule signaling and detection systems in protists and bacteria." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1155564098.

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13

He, Fei. "On robust approaches in systems identification for biochemical signaling pathways." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.695231.

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14

Hughes, Hallett James. "Systems Level Analysis of TORC1 Pathway Signaling in S. cerevisiae." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/556430.

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The target of rapamycin complex I (TORC1) regulates cell growth and metabolism in all eukaryotes. Previous studies have shown that nitrogen and amino acid signals activate TORC1 via three GTPases; Gtr1, Gtr2, and Rho1, and the SEA-associated Npr2/3 proteins. However, little is known about the way that other nutrient or stress signals are transmitted to TORC1. Here I present two studies identifying how, and at what level, glucose and other environmental stimuli act to tune TORC1 signaling. In the first study I show that the TORC1 pathway populates three additional stress/starvation states. Firs
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15

Cierpial, Edwin C. "Is open book testing viable within a military occupational producing school 25 uniform, Signal Support Systems Specialist, at Fort Gordon, GA." Online version, 2009. http://www.uwstout.edu/lib/thesis/2009/2009cierpiale.pdf.

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16

Ullah, Ghanim. "COMPUTATIONAL MODELING OF CALCIUM SIGNALING FROM THE NANOSCALE TO MULTICELLULAR SYSTEMS." Ohio University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1160584521.

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17

Gafurzade, Elchin. "Development of an automation tool for data configuration of signaling systems." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020.

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This thesis work, which was realized at ALSTOM S. p. A., focuses on the communication between trackside equipment and the train, which is performed via various protocols to have information in advance about the state of the railway. The object is developing, after a careful analysis of the communication system, the software for the configuration parameters of the database files. Chapter 1, after a brief review of the European regulatory environment in railroad, explains the European Railway Traffic Management System (ERTMS), the European Train Control System (ETCS), and the radio-based telec
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18

Krjukova, Jelena. "Investigation on Pre- and Postsynaptic Ca2+ Signaling in Neuronal Model Systems." Doctoral thesis, Uppsala universitet, Institutionen för neurovetenskap, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4300.

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Communication between neuronal and non-neuronal is called volume transmission when the released neurotransmitter (NT) acts via diffusion and affects several target cells. Both the neurosecretory and postsynaptic cell responses are linked to [Ca2+]i elevations. In the present thesis the role of pre-and postsynaptic Ca2+ elevations has been investigated in the reconstituted "synapse" model comprised of NGF-differentiated PC12 and HEL cells as well as in SH-SY5Y neuroblastoma cells. In PC12 cells, both 70mM K+ and nicotine triggered NT release, which could be detected as a secondary [Ca2+]i incr
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19

Moosavi, Reza. "Improving the Efficiency of Control Signaling in Wireless Multiple Access Systems." Doctoral thesis, Linköpings universitet, Kommunikationssystem, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-102537.

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Prior to the transmission of payload data in any multiple access system, there is generally a need to send control information such as scheduling assignments, transmission parameters and HARQ acknowledgments. This process is called control signaling and has a significant impact on the overall system performance. This dissertation considers different aspects of control signaling and proposes some novel schemes for improving it. The dissertation is split into two parts where in the first part the focus is on the transmission of scheduling assignments, and in the second part the focus is on impro
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20

Liu, Daniel Ning. "Capacity approaching and efficient signaling schemes for wideband wireless communication systems." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1580690051&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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21

Oxhorn, Brian C. "Compartmentation of apoptotic signaling in cardiac endothelial and model cell systems /." abstract and full text PDF (UNR users only), 2002. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3090876.

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22

Mokdad, Audrey. "Time-resolved thermodynamics studies of heme signaling proteins and model systems." [Tampa, Fla] : University of South Florida, 2009. http://purl.fcla.edu/usf/dc/et/SFE0003063.

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23

Jin, Junyang. "Novel methods for biological network inference : an application to circadian Ca2+ signaling network." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/285323.

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Biological processes involve complex biochemical interactions among a large number of species like cells, RNA, proteins and metabolites. Learning these interactions is essential to interfering artificially with biological processes in order to, for example, improve crop yield, develop new therapies, and predict new cell or organism behaviors to genetic or environmental perturbations. For a biological process, two pieces of information are of most interest. For a particular species, the first step is to learn which other species are regulating it. This reveals topology and causality. The second
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24

Huang, Shao-shan Carol. "A constraint optimization framework for discovery of cellular signaling and regulatory networks." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/65772.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Computational and Systems Biology Program, 2011.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Cellular signaling and regulatory networks underlie fundamental biological processes such as growth, differentiation, and response to the environment. Although there are now various high-throughput methods for studying these processes, knowledge of them remains fragmentary. Typically, the majority of hits identified by transcriptional, proteomic, and genetic assays lie outside of the expected pathways. In ad
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Kanso, Karim. "Agda as a platform for the development of verified railway interlocking systems." Thesis, Swansea University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678306.

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26

Zhang, Tongli. "Mathematical Models of Some Signaling Pathways Regulating Cell Survival and Death." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/29443.

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In a multi-cellular organism, cells constantly receive signals on their internal condition and surrounding environment. In response to various signals, cells proliferate, move around or even undergo suicide. The signal-response is controlled by complex molecular machinery, understanding of which is an important goal of basic molecular biological research. Such understanding is also valuable for clinical application, since lethal diseases like cancer show maladaptive responses to growth-regulating signals. Because the multiple feedbacks in the molecular regulatory machinery obscure cause-effect
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27

Walklin, Sheldon Samuel. "Multilevel signaling for increasing the capacity of high-speed optical communication systems." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/nq23088.pdf.

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28

Thobe, Kirsten [Verfasser]. "Logical modeling of uncertainty in signaling pathways of cancer systems / Kirsten Thobe." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1136608877/34.

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29

Ishchenko, Andrii [Verfasser]. "Molecular mechanisms of signal transduction in two-component signaling systems / Andrii Ishchenko." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2013. http://d-nb.info/1038680530/34.

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30

Chen, Peggy B. (Peggy Bing-Jen) 1977. "Modular high-speed signaling for networks in HPC systems using COTS components." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/86293.

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Thesis (S.B. and M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2000.<br>Includes bibliographical references (leaves 108-110).<br>by Peggy B. Chen.<br>S.B.and M.Eng.
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31

Lu, Michelle. "The Construction and Deconstruction of Signaling Systems that Regulate Mitotic Spindle Positioning." Thesis, University of Oregon, 2013. http://hdl.handle.net/1794/12955.

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Signaling systems regulate the flow of cellular information by organizing proteins in space and time to coordinate a variety of cellular activities that are critical for the proper development, function, and maintenance of cells. Signaling molecules can exhibit several levels of complexity through the utilization of modular protein interactions, which can generate simple linear behaviors or complex behaviors such as ultrasensitivity. Protein modularity also serves as the basis for the vast protein networks that form the regulatory networks that govern several biological activities. My work
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Hinman, Lee E. "The role of second messenger signaling following mechanical injury /." Diss., ON-CAMPUS Access For University of Minnesota, Twin Cities Click on "Connect to Digital Dissertations", 1999. http://www.lib.umn.edu/articles/proquest.phtml.

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33

Amin, Munia. "Exploring and understanding signal-response relationships and response dynamics of microbial two-component signaling systems." Thesis, University of Exeter, 2013. http://hdl.handle.net/10871/15016.

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Two-component signaling systems are found in bacteria, fungi and plants. They mediate many of the physiological responses of these organisms to their environment and display several conserved biochemical and structural features. This thesis identifies a potential functional role for two commonly found architectures in two-component signaling system, the split kinases and phosphate sink, which suggests that by enabling switch-like behaviors they could underlie physiological decision making. I report that split histidine kinases, where autophosphorylation and phosphotransfer activities are segre
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Feng, Yi. "Design of non-uniform signaling and multi-user demodulation/decoding for CDMA systems." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114263.

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The third generation (3G) smart phones have been widely commercialized in many parts of the world, and they have become popular communication devices, which aim to provide fast and reliable wireless transmission in people's daily life. Code-division multiple-access (CDMA) offers many key advantages including secure data transmission, resistance to jamming and interference, total bandwidth usage, which have made CDMA a key technology used in the current 3G standards. In addition, single-user demodulation and decoding (SUD) have been adopted by the receiver of 3G CDMA systems due to the low impl
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Wiredja, Danica. "Phosphoproteomic Characterization of Systems-Wide Differential Signaling Induced by Small Molecule PP2A Activation." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1511288772792226.

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36

Li, Shengchun. "Antioxidant systems and protein phosphatases in metabolic and signaling responses to oxidative stress." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112086.

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Le stress oxydant est un acteur clé dans les réponses des plantes à des conditions contraignantes. En raison de la complexité de la régulation de l’état redox cellulaire, il reste beaucoup à élucider concernant les interactions entre différentes composantes dans ces conditions. Grâce à une approche de génétique inverse basée sur un mutant d’Arabidopsis déficient en catalase (cat2) qui présente des modifications d’état redox prévisibles et bien définies, cette étude a exploré les interactions entre le stress oxydant et (1) un gène spécifique impliqué dans la déphosphorylation des protéines, (2)
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37

Willett, Jonathan. "Bacterial two-component systems share a common mechanism to regulate signaling and specificity." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/4977.

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Despite years of intensive research, many of the fundamental aspects of two-component signal transduction pathways are not yet understood. Interestingly these systems are found throughout all domains of life including archaea, bacteria and eukaryotes and are known to regulate diverse cellular processes such as motility, pathogenesis, development, biofilm formation, and toxin production. Despite many groups working on two-component systems it is not yet appreciated whether these systems have conserved features, amino acid requirements, structures and specificity. By understanding the mechanisms
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Goetz, Rebekka [Verfasser], and Annette [Akademischer Betreuer] Neubüser. "FGF signaling in mouse olfactory placode development = Der FGF Signalweg und seine Rolle während der Entwicklung des olfaktorischen Systems der Maus." Freiburg : Universität, 2012. http://d-nb.info/1123472912/34.

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39

Garvey, Matthew Thomas. "Diffusion Mediated Signaling: Information Capacity and Coarse Grained Representations." online version, 2009. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=case1233592563.

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40

Mazo, Camille. "GABAergic signaling in cortical feedback to the olfactory bulb." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066066/document.

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Les projections corticales de retour conduisent l'information vers des relais de traitement de l'information plus précoces. Elles sont essentielles pour la perception sensorielle. En ce qui concerne l'olfaction, l'information sensorielle est constituée d'une multitude de molécules odorantes, et c'est ce mélange complexe qui pénètre dans la cavité nasale. En fonction du contexte, c'est une partie ou une autre de cet ensemble de molécules qui va être importante d'un point de vue comportemental. Les signaux corticaux de retour permettraient de focaliser son attention sur les odeurs pertinentes de
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41

Uschner, Friedemann. "Information processing in cellular signaling." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17660.

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Information spielt in der Natur eine zentrale Rolle. Als intrinsischer Teil des genetischen Codes ist sie das Grundgerüst jeder Struktur und ihrer Entwicklung. Im Speziellen dient sie auch Organismen, ihre Umgebung wahrzunehmen und sich daran anzupassen. Die Grundvoraussetzung dafür ist, dass sie Information ihrer Umgebung sowohl messen als auch interpretieren können, wozu Zellen komplexe Signaltransduktionswege entwickelt haben. In dieser Arbeit konzentrieren wir uns auf Signalprozesse in S.cerevisiae die von osmotischem Stress (High Osmolarity Glycerol (HOG) Signalweg) und der Stimulation
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Krjukova, Jelena. "Investigation on Pre- and Postsynaptic Ca2+ Signaling in Neuronal Model Systems." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4300.

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Hadkhale, I. (Ishwor). "Faster than Nyquist signaling and analysis of Its performance under uncoded/coded transmission systems." Master's thesis, University of Oulu, 2015. http://urn.fi/URN:NBN:fi:oulu-201505281713.

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The future demand of increased transmission rate and bandwidth efficiency is of prime concern in the modern wireless communication systems. Faster than Nyquist signaling (FTN) is under the great interest of research to address this issue of high data rate, which is also a major requirement, for the fifth generation (5G) communication networks. The data bits are transmitted at a rate higher than the conventional methods which are bounded by the Nyquist condition and the outputs are compared so as to analyze the benefits. Receiver processing techniques are implemented to achieve the high data r
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Hanikat, Marcus. "Towards a Correct-by-Construction design flow : A case-study from railway signaling systems." Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-299362.

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As technological advancements and manufacturing techniques continues to bring us more complex and powerful hardware, software engineers struggle to keep up with this rapid progress and reap the benefits brought by this hardware. In the field of safety-critical system development, where a thorough understanding and deterministic nature of the hardware often is required, the cost of development closely relates to the complexity of the hardware used. For software developers to be able to reap the benefits of the technological advancement in hardware design, a Correct-by-Construction with a model-
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MILANESI, RICCARDO. "Metabolism and signaling crosstalk regulates nutrients perception and mitochondrial respiration in eukaryotic model systems." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/375389.

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Tutti gli eucarioti presentano sistemi di percezione per le fonti di carbonio e azoto tramite la quale la crescita cellulare è coordinata con lo stato nutrizionale. In particolare, I metaboliti della parte alta della glicolisi influenzano lo stato di attivazione della via di PKA e di Snf1/AMPK/SnRK1 in lievito, mammifero e piante. Mentre, la via del complesso di TORC1 è al centro di un sistema di segnalazione per la disponibilità di amminoacidi. Di particolare interesse è il meccanismo di interazione tra la via di Snf1/AMPK e Ras/PKA con il metabolismo del glucosio la cui regolazione non è tut
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LUO, Huajiang. "Information leakage and sharing in decentralized systems." Digital Commons @ Lingnan University, 2018. https://commons.ln.edu.hk/otd/35.

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This thesis presents two essays that explore firms’ incentive to share information in a multi-period decentralized supply chain and between competing firms. In the first essay, we consider a two-period supply chain in which one manufacturer supplies to a retailer. The retailer possesses some private demand information about the uncertain demand and decides whether to share the information with manufacturer. If an information sharing agreement is achieved, the retailer will share the observed demand information truthfully to the manufacturer. Then the selling season with two periods starts. In
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Draheim, Roger Russell. "The role of protein-membrane interactions in modulation of signaling by bacterial chemoreceptors." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1336.

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48

Chen, Chun. "Systems Biology Study of Breast Cancer Endocrine Response and Resistance." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/51965.

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As a robust system, cells can wisely choose and switch between different signaling programs according to their differentiation stages and external environments. Cancer cells can hijack this plasticity to develop drug resistance. For example, breast cancers that are initially responsive to endocrine therapy often develop resistance robustly. This process is dynamically controlled by interactions of genes, proteins, RNAs and environmental factors at multiple scales. The complexity of this network cannot be understood by studying individual components in the cell. Systems biology focuses on the i
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Finn, Nnenna Adimora. "Role of redox systems in doxorubicin metabolism and doxorubicin-mediated cell signaling: a computational analysis." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41149.

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Insensitivity to chemotherapy is an ongoing issue in cancer treatment, one that appears to be highly dependent on patient-specific variations. It has been shown clinically that while a subset of patients will successfully respond to a particular chemotherapeutic regimen, there exists another subset of patients who when exposed to the same course of therapy will remain resistant to treatment or exhibit signs of relapse after treatment has been administered. This discrepancy raises interesting questions regarding the role that patient-specific variations play in controlling the efficacy of chemo
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Wadewitz, Philip [Verfasser], Julia [Akademischer Betreuer] Fischer, and Fred [Akademischer Betreuer] Wolf. "Processing of Graded Signaling Systems / Philip Wadewitz. Betreuer: Julia Fischer. Gutachter: Julia Fischer ; Fred Wolf." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://d-nb.info/1094077410/34.

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