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Dissertations / Theses on the topic 'Signalling effect'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

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1

Steinwald, Hannah. "Effect of signalling a positive reinforcer on contextual conditioning." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59864.

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Three experiments used an appetitive Pavlovian conditioning procedure to investigate the ability of the context to generate excitation. Discrete stimuli (CSs) signalling food unconditioned stimuli (USs) were used to decrease contextual conditioning. Detailed observations of the behaviours of rats during and immediately preceding the presentation of CSs, and in an event-free period were analysed. Experiment 1 showed that a discrete visual CS was able to interfere with contextual conditioning because it was a more efficient cue for food than the context. Experiment 2 found that an auditory CS co

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2

Hopkinson, Helen Elizabeth. "Betaâ†2-adrenoceptor signalling and the effect of insulin." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301070.

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3

Scott, Sarah Anne. "The effect of glial signalling on dopamine neuronal differentiation." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612827.

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4

Wong, Tin Lok. "Mechanism of action of silicon in cell signalling." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709339.

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5

Giuliano, Simon 1975. "Calcium signalling regulating platelet adhesion and thrombus growth." Monash University, Dept. of Medicine, 2002. http://arrow.monash.edu.au/hdl/1959.1/7875.

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6

Pandey, Vibhor. "Quality signalling: The effect of innovation programs on innovation-driven enterprises." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/209165/1/Vibhor_Pandey_Thesis.pdf.

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This thesis takes a novel approach to evaluate the impact of the public policies of innovation and entrepreneurship on individual firms. This evaluation research uses 10-year time series data on Queensland businesses, Advance Queensland (AQ) program data and public datasets to investigate what types of companies get selected for the AQ program and the overall impact of these policies on innovation-driven entrepreneurship. The study found corrective general market behaviour and had a significant effect on the firms. The thesis contributes to the theory of entrepreneurial “Quality Signalling” an

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7

Wadley, Glenn, and mikewood@deakin edu au. "Regulation of insulin signalling by exercise in skeletal muscle." Deakin University. School of Health Sciences, 2003. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20050826.111050.

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Regular physical activity improves insulin action and is an effective therapy for the treatment and prevention of type 2 diabetes. However, little is known of the mechanisms by which exercise improves insulin action in muscle. These studies investigate the actions of a single bout of exercise and short-term endurance training on insulin signalling. Twenty-four hours following the completion of a single bout of endurance exercise insulin action improved, although greater enhancement of insulin action was demonstrated following the completion of endurance training, implying that cumulative bouts

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Al-Abri, Abdulrahim. "Investigating the effect of PIP4K2a overexpression in insulin signalling in L6 myotubes." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/investigating-the-effect-of-pip4k2a-overexpression-in-insulin-signalling-in-l6-myotubes(1dd2d1dd-c765-4830-9b66-cf32a64d7de9).html.

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Insulin signalling is an essential process in humans by which the level of plasma glucose is maintained within the physiologically healthy range. Insulin activates the phosphoinositide 3 kinase (PI3K) signalling pathway that generates the phospholipid messenger PtdIns(3,4,5)P3, which in turn enhances the activity of two important proteins, AKT and Rac1. This then leads to increase the presence of the glucose transporter 4 (GLUT4) at the plasma membrane that enhances the intake of glucose, particularly in skeletal muscle cells and adipocytes. Insulin signalling also triggers interconversion of

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9

Ali, Tarek Adel. "Effect of implant surface roughness on the NFkB signalling pathway in macrophages." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/2436.

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Physical stress such as the surface roughness of the implants may activate the NFkB signalling pathway in macrophages. This activation is intimately related to the mechanism(s) by which the macrophage interacts with the surface through serum proteins and/or the formation of membrane rafts. This thesis examines the role of surface topography on activation of the NFkB signalling pathway in macrophages. We examined the effect of implant surface topography on activating the NFkB signalling pathway in the RAW 264.7 macrophage cell line. We also examined the effect surface roughness had on the adhes

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10

Zihni, Ceniz. "The effect of adrenomedullin on growth-associated signalling pathways in vascular cells." Thesis, Queen Mary, University of London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396311.

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11

Barnard, Joanna Catherine. "The effect of thyroid hormones on fibroblast growth factor signalling in bone." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419226.

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12

Hall, Caroline Jane. "The effect of GPCR crosstalk on intracellular Ca2+ responses and downstream signalling." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/9528.

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13

Kwong, Wing Yee. "The effect of hyperthermia on the phosphoinositide signalling system of tumour cells." Thesis, Durham University, 1994. http://etheses.dur.ac.uk/6114/.

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The effect of heat on the phosphoinositide signalling pathway was investigated in CHO-K1 cells and WRK-1 cells. Heat caused a decrease in 1,2-diacylglycerol (1,2- DAG) levels but did not have any effect on monoacylglycerol (MAG) levels in both cell types. On the other hand, an increase in triacylglycerol (TAG) level was observed in both cell lines. This heat-induced decrease in 1,2-DAG level in WRK-1 cells was not due to an increase in turnover rate of 1,2-DAG to phosphatidic acid (PA) since the decrease in 1,2-DAG was not affected when cells were heated in the presence of die DAG kinase inhib

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14

Jones, Sarah Elizabeth. "The effect of cAMP elevation on intracellular signalling pathways in prostate epithelial cells." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/1668/.

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Chronic IL-6 signalling contributes to the pathophysiology of many diseases including prostate cancer. Relevant to prostate cancer is the ability of the pro-inflammatory cytokine IL-6 to activate the oncogenic signalling protein STAT3, thus inhibition of STAT3 activation is a popular avenue of research to augment prostate cancer therapies. In this study, the endogenous anti-inflammatory molecule cAMP was investigated as a mechanism by which to inhibit IL-6-induced STAT3 activation in the DU145, LNCaP and PZ-HPV-7 prostate epithelial cells. Elevation of cAMP attenuated IL-6-mediated activation

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15

Peralta, Rubén Darío. "The effect of hyposmotic shock on motility and calcium signalling of human spermatozoa." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/3105/.

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Chloride (Cl\(^-\)) channels are thought to be implicated in volume regulation of human spermatozoa, a process vital for diverse cell functions. The Cl\(^-\) channel blockers DIDS, NPPB and niflumic acid were utilized to evaluate the influence of Cl\(^-\) channels on motility, morphology and [Ca\(^{2+}\)]\(_i\) signaling of human spermatozoa exposed to hyposmotic shock (295, 270 and 200 mOsm, equivalent to the osmotic conditions of cervical mucus, fallopian tubes, and non physiological respectively). At 295 and 270 mOsm, 50 and 100 μM DIDS inhibited motility whereas 400 μM abolished it. 400 μM

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Zhou, C. "Effect of prostate cancer-related plexin-B1 mutations on cell signalling and function." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/19580/.

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Prostate cancer is one of the most common cancers in the Western world. The metastasis of prostate cancer cells is the major cause of prostate cancer-related death. Understanding which genes are altered in prostate cancer and their implications for cell signaling and function is crucial for designing therapy strategies. Our group has identified a high frequency of somatic missense mutations in the plexin-B1 gene in localized and metastatic prostate cancer. The mutations are correlated with elevated metastatic features such as increased cell invasion, adhesion and decreased cell collapse relati

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17

Ziviani, Elena. "Long term effect of nicotinic acetylcholine receptor activation and downstream signalling in neurons." Thesis, University of Leicester, 2005. http://hdl.handle.net/2381/30777.

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Nicotinic acetylcholine receptors (nAChRs) are widely present in the central nervous system (CNS). However, their cellular functions and physiological significance are not yet fully understood. Recently, in vivo and in vitro studies have suggested a possible neuroprotective role for nAChRs. Exposure to nicotine, an agonist at nAChRs, has been shown to protect from neurotoxicity induced by NMDA, glutamate and potassium withdrawal, and to prevent beta-amyloid induced neurotoxicity. Furthermore, stimulation of nAChRs has been shown to delay the ageing process of nigrostriatal neurons, increase ne

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Hong, Xinyang. "The balancing effect between MAPK and NFκB pathways for the transcriptional regulation of Toll-like receptors". Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:a9d64615-68b1-46eb-a2d3-4eb8d1827a27.

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Toll-like receptors (TLR) are a family of pattern recognition receptors crucial for pathogen pattern recognition. Upon activation, TLRs induce innate immune responses such as cytokine production. However irregular TLR activities can provide fatal, hence fine tuning of the TLR induced responses are necessary. The TLR mediated immune responses are controlled by the positive/negative regulation of TLR signalling pathways, relocation of TLR proteins and modulation of TLR transcription. Systematic analyses of the agonist-induced transcriptional changes of TLRs were shown for the first time in my th

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19

McConville, Maeve. "Platelet free radical signalling in type II Diabetes Mellitus : effect of fish oil supplementation." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492027.

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Chapter 1 introduces the pathological changes that occur in the endothelium during diabetes mellitus (OM). Sources of nitric oxide, superoxide and the enzymes responsible for free radical production are defined within the vascular system in health and dysfunction. Therapeutic properties of omega-3 PUFA are discussed and the implications for cardiovascular disease. The aim of this thesis was to shed more light on the role of caveolin-1 in pathogenesis of OM II by using a well established platelet model for vascular endothelium. Also to evaluate the impact of omega-3 fatty acids derived from fis

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20

Sonnenberg, Mariële. "The signalling effect of HRM on psychological contracts of employees a multi-level perspective /." [Rotterdam] : Rotterdam : Erasmus Research Institute of Management (ERIM), Erasmus University Rotterdam ; Erasmus University [Host], 2006. http://hdl.handle.net/1765/7995.

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21

Dilworth, Emma. "Effect of intracellular pH on CaÂ²âº signalling in isolated mammalian ventricular myocytes." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400104.

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22

Abdelrazzak, Abdelrazek Bedir. "The effect of low-dose ionising radiation on signalling and intercellular induction of apoptosis." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534004.

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23

Swaffield, James B. "Environmental harshness and its effect on appetite and the desire for conspicuous signalling products." Thesis, University of Stirling, 2017. http://hdl.handle.net/1893/27239.

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There is often an assumption that there is a right and a wrong way for consumers to behave. For example, with regard to eating, people should make food choices based on maximizing vitamins and minerals and not consuming more calories than one expends in a day. Likewise, it is assumed that buying products to conspicuously signal a message to another is wasteful and maladaptive. The research in this thesis challenges these assumptions and argues that these behaviours can be both adaptive and maladaptive depending on one’s environmental conditions. In this thesis, I describe three experiments tha

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Murphy, Emer. "The effect of extrinsic blockade of TILRR on NF-κB signalling and identification of a novel function of TILRR in non-canonical NF-κB signalling". Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/13792/.

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25

Chhatwal, Alisha Kaur. "Investigating the effect of a 3D physical microenvironment on hepatocyte structure, function, and adhesion signalling." Thesis, Durham University, 2016. http://etheses.dur.ac.uk/11764/.

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Presenting cells with a two-dimensional (2D) substrate, as is the case with traditional cell culture, causes them to aberrantly flatten out, and lose their characteristic cell shape. With the case of liver cells, their cuboidal cell shape is vital to cell -specific functions, such as xenobiotic metabolism. Accordingly, culturing hepatocytes in 2D may produce results that do not accurately reflect the behavior of such cells in-vivo. Cells in vivo are in constant contact with the ECM across three dimensions whereas culturing cells in 2D monolayers will alter the geometry of the cell leading to c

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Liu, Donghui. "The role of CD105 in angiogenesis and its effect on cell signalling and gene expression." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493918.

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Angiogenesis is an invasive cellular process that requires the functional activity of a wide range of molecules including growth factors and their receptors, extracellular metrix proteins, adhesion molecules and proteolytic enzymes. CD 105 is a ISOkDa homodimeric transmembrane glycoprotein expressed at high levels in tumour endothelial cells (ECs) and to a lesser extent in normal ECs. CD 105 is an important component of transforming growth factor-beta (TGF-β) receptor complex and a modulator of TGF-β signalling by interacting with TGF-β receptor I (TβR-I) and/or TGF-β receptor II (TβR-II). CD

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Robertson, Abigail. "Targeting the Hippo signalling pathway to enhance the protective effect of iPS cell derived cardiomyocytes." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/targeting-the-hippo-signalling-pathway-to-enhance-the-protective-effect-of-ips-cell-derived-cardiomyocytes(f80b12c7-5289-46f9-8829-28224f0c6270).html.

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Cell based therapy using stem cell derived cardiomyocytes, has emerged as a potential therapeutic approach for cardiac diseases such as myocardial infarction and heart failure. Induced pluripotent stem cells (iPS cells) could be an ideal source of cardiomyocytes (iPS-CM). Challenges facing cell therapy include the high number of viable cells needed to survive in pathological conditions. The Hippo signalling pathway has been described as a key pathway involved in regulating cardiomyocyte proliferation and survival in both embryonic and adult hearts. We hypothesise that modification of the Hippo

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28

Birch, Rebecca Elizabeth. "The effect of serine proteases on ATP-signalling in renal tubules and medullary micro vessels." Thesis, University of Kent, 2015. https://kar.kent.ac.uk/50031/.

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An estimated 2% of the human genome encodes for proteolytic enzymes. It is becoming increasingly apparent that serine proteases have diverse and critical roles in many physiological and pathophysiological processes. Studies investigating the role of serine proteases in the kidney have focussed primarily on their pro-inflammatory effects and their ability to cleave and activate the epithelial sodium channel (ENaC). P2X receptors, which are structurally very similar to ENaC and have been identified throughout the nephron and in the renal vasculature, are thought to contribute to the regulation o

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Franklin, Eric Robert. "The role of oxygen as a stressor, metabolite and signalling molecule and its effect on cell proliferation." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/121736/1/Eric_Franklin_Thesis.pdf.

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This thesis is a comparative study of how different oxygen concentrations alter the proliferation, energy metabolism, protection against oxidized molecules, and phenotype of a variety of cancer cell lines. It examines three different oxygen concentrations and their impact, utilizing expansion assays, analysis of genetic expression of enzymes involved in energy metabolism and oxidative protection, and microscopic images. What was revealed was that the level of oxygen has a varied effect on cellular proliferation depending on cell type, the details of which need to be explored. Additionally, the

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Bose, Diptiman Dipen. "Role of ryanodine receptors in neuronal calcium signalling and growth control." Scholarly Commons, 2002. https://scholarlycommons.pacific.edu/uop_etds/566.

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The versatility of Ca2+ as a messenger regulating a myriad of signalling events requires that the concentration of Ca2+ ions in the cytoplasm be highly regulated. Capacitative Ca2+ entry (CCE) or store-operated Ca2+ (SOC) entry, whereby the depletion of intracellular Ca2+ stores induces the influx of Ca2+ across the plasma membrane, plays a crucial role in Ca2+ signalling. Despite the recent advances in elucidating the entry pathway, its molecular identity, biophysical properties and store-depletion signal remains undefined. Thapsigargin (TG), a sarcoplasmic/endoplasmic reticulum Ca2+ A TPase

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Stelma, Tamara. "The effect of inhibiting KPNB1-mediated nuclear import on cancer cell biology and inflammatory transcription factor signalling." Doctoral thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/27888.

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Cancer remains one of the major causes of morbidity and mortality globally. Many novel and innovative approaches have been employed to develop new chemotherapeutic strategies, of which targeted therapies aim to identify a molecular lesion or dysregulated pathway that cancer cells are dependent on. Research in our laboratory and others identified the nuclear import protein, Karyopherin β1 (KPNB1), to be overexpressed in various cancers and that inhibiting its expression blocks the proliferation of cancer cells. However, little is known about the potential role of KPNB1 in other cancer cell phen

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Mughal, Tabasum. "The effect of transforming growth factor-β1 on the Nrf2 antioxidant signalling pathway in human aortic adventitial fibrolasts". Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/the-effect-of-transforming-growth-factor1-on-the-nrf2-antioxidant-signalling-pathway-in-human-aortic-adventitial-fibrolasts(8ee77331-a5d4-4384-86dc-7eedefa4d41d).html.

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Vascular remodelling in arterial disease is characterised by vascular smooth muscle cell and adventitial fibroblast (AF) proliferation and migration due to mechanical and oxidative stresses within the vessel wall, leading to enhanced growth factor signalling. Transforming growth factor β-1 (TGF-β1) is a pleiotropic growth factor that mediates vascular remodelling through eliciting phenotypic changes in AF, which may result from the generation of reactive oxygen species (ROS). Nrf2 is a key transcription factor that co-ordinates expression of endogenous antioxidant defense genes such as heme ox

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33

Newens, Katie J. "Effect of non-esterified fatty acid composition on vascular function : acute postprandial and in vitro insulin signalling studies." Thesis, University of Reading, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558750.

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Background Elevated levels of circulating non-esterified fatty acids (NEFA) are often observed during type 11 diabetes and have been proposed as a contributory factor for atherosclerosis. Experimental elevation of NEFA in healthy subjects impairs vascular function, but the impact of NEFA fatty acid composition is unclear. In vitro studies implicate a role for fatty acid-induced defects in insulin signalling, but these may be limited by unphysiological experimental exposures. Aim To examine the effect of varying NEFA concentration and fatty acid composition on vascular function, and explore the

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Farrell, Sam Hanno. "Adaptive evolution in the Pseudomonas fluorescens Wsp signalling pathway : exploring the relationship between genetic cause and phenotypic effect." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/adaptive-evolution-in-the-pseudomonas-fluorescens-wsp-signalling-pathway-exploring-the-relationship-between-genetic-cause-and-phenotypic-effect(d4fc7a28-6da0-477b-9315-34f4b4d71f76).html.

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When provided with spatial niches by growth in static nutrient medium, Pseudomonas fluorescens diversifies through adaptive radiation into several well-defined phenotype classes. One of these classes, named wrinkly spreader (WS) for its morphology on agar medium, forms a biofilm at the air-liquid interface through mutations in one of several loci including the genes wspF and awsX. These genes code for negative regulators of di-guanylate cyclases (DGCs). These DGCs catalyse synthesis of cyclic-di-GMP, a second messenger, overproduction of which effects physiological changes leading to overprodu

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Mardaryev, Andrei N. "Role of the bone morphogenetic protein signalling in skin carcinogenesis : effect of transgenic overexpression of BMP antognist Noggin on skin tumour development : molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4320.

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Bone morphogenetic protein (BMP) signalling plays key roles in skin development and also possesses a potent anti-tumour activity in postnatal skin. To study mechanisms of the tumour-suppressive role of BMPs in the skin, a transgenic (TG) mouse model was utilized, in which a transgenic expression of the BMP antagonist Noggin was targeted to the epidermis and hair follicles (HFs) via Keratin 14 promoter. K14-Noggin mice developed spontaneous HF-derived tumours, which resembled human trichofolliculoma. Initiation of the tumours was associated with a marked increase in cell proliferation and an ex

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Yuka, Sai. "The Effect of Amyloid-Beta on the Insulin Signalling Pathway in Neuroblastoma 2a (N2a) Cells: The Characterization of Insulin Resistance in Alzheimer’s Disease." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34248.

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7Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by accumulation and deposition of extracellular beta-amyloid peptides (Aβ) and intra-neuronal hyperphosphorylated tau in the brain. The insulin signalling pathway begins upstream at the insulin receptor (IR), where the intracellular insulin receptor substrate 1 (IRS1) is phosphorylated, thus propagating the signal downstream to the PI3K/Akt signalling pathway, which affects both the glycogen synthase kinase 3 beta (GSK3β), which is a tau kinase, and mTOR, which is a critical part of the mTORC1 and mTORC2 comple

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Andrikopoulos, Petros. "The effect of ionic fluxes on cell signalling and the angiogenic properties of human umbilical vein vascular endothlial cells ( HUVECs) in vitro." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520939.

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Kaskar, Rafee'ah. "Effect of melatonin on myocardial susceptibility to ischaemia and reperfusion damage in a rat model of high-fat diet-induced obesity." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/97868.

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Thesis (MScMedSc)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: Obesity has reached epidemic proportions worldwide and is currently a serious health problem. It is associated with metabolic abnormalities, oxidative stress, hypertension, insulin resistance and an increased disposition for the development of cardiovascular disease. Elucidation of the pathophysiological mechanisms underlying obesity and its relationship with metabolic and cardiovascular diseases is essential for prevention and management of these disorders. Melatonin, the pineal gland hormone, is a powerful antioxidan

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Hawcroft, Gillian, Paul M. Loadman, Andrea Belluzzi, and Mark A. Hull. "Effect of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signalling in human colorectal cancer cells." Neoplasia Press, 2010. http://hdl.handle.net/10454/4551.

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The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA), in the free fatty acid (FFA) form, has been demonstrated to reduce adenoma number and size in patients with familial adenomatous polyposis. However, the mechanistic basis of the antineoplastic activity of EPA in the colorectum remains unclear. We tested the hypothesis that EPA-FFA negatively modulates synthesis of and signaling by prostaglandin (PG) E(2) in human colorectal cancer (CRC) cells. EPA-FFA induced apoptosis of cyclooxygenase (COX)-2-positive human HCA-7 CRC cells in vitro. EPA-FFA in cell culture medium was incorpo

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Datta, S. N. "Cholinergic signalling pathways in the superficial layers of the human bladder : comparing health, detrusor overactivity and the effect of Botulinum Toxin Type A." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1301774/.

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Introduction: Muscarinic receptors have been identified both in the suburothelium and urothelium of the human bladder. It has been proposed that increased release of Acetylcholine (ACh) from the urothelial and suburothelial nerves may act on suburothelial and detrusor muscarinic receptors, resulting in detrusor overactivity (DO). Neuropeptide Y (NPY) is a cholinergic co-transmitter. Botulinum neurotoxin type A (BoNT/A) is known to act by blocking the release of ACh. We compared expression of M1, M2, M3 receptors, NPY and SNAP-25 in patients with DO, controls and following successful treatment

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Badrian, Bahareh. "Evaluation of the consequences of ERK and STAT3 activation in the heart." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0027.

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[Truncated abstract] The enlargement of the heart, also known as myocardial hypertrophy, is thought to be a compensatory process that maintains the mechanical function of the heart in response to stress factors such as pressure or volume overload. Although this process is initially compensatory, it frequently results in heart failure and death. Cardiac hypertrophy is a complex process involving changes in the individual cardiac muscle cells, cardiac myocytes. As well as the morphological changes that result from hypertrophy, there are molecular changes within each cell that regulate the hypert

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Käbisch, Romy Astrid [Verfasser], Markus [Akademischer Betreuer] Gerhard, and Dirk [Akademischer Betreuer] Haller. "Effect of Helicobacter pylori infection on dendritic cell maturation, signalling and subsequent adaptive immune response / Romy Astrid Käbisch. Gutachter: Dirk Haller ; Markus Gerhard. Betreuer: Markus Gerhard." München : Universitätsbibliothek der TU München, 2013. http://d-nb.info/1060482630/34.

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Tóth, Szilvia. "Glucocorticoid receptor signalling and the effect of interleukin-1[beta] [interleukin-1beta] on glucocorticoid mediated gene expression in intestinal epithelial cell lines CACO-2 and IEC-6." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=961249722.

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Ballen, Margaret. "Biology of colour signalling reptiles." Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/10034.

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Given abundant evidence that suggests colour patches serve as important social signals in reptiles, the ‘honesty’ of such colours can be best understood in relation to the mechanisms mediating colour expression. One such mechanism is oxidative stress by free radicals. The first part of my PhD thesis thus focuses on factors that dictate signal phenotype and expression with an emphasis on free radicals, which constrain fitness-related traits such as colour. We show that systemic free radical levels change in opposing ways among the sexes in response to different activity levels in the painted dr

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Hubbard, Gary. "In vitro and in vivo effects of dietary polyphenols on platelet function." Thesis, University of Reading, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270840.

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Nowak, Julia S. "Effects of adaxial-abaxial signalling on leaf polarity." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42881.

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The unifying theme of this thesis is adaxial-abaxial or dorsiventral patterning in leaves. The adaxial-abaxial axis sets the thickness of a leaf and without the appropriate juxtaposition of the adaxial and abaxial domains, radialized leaves develop. The underlying genetic mechanisms of the development of these polarity defects started to be elucidated only over the past 20 years in the model Arabidopsis, in particular. I investigated this patterning in a variety of non-model species. Firstly, I investigated the variability of dorsiventral polarity in plants with naturally occurring radialized

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Carnegie, Andrew Mark. "Effects of C.perfringens alpha toxin on cell signalling." Thesis, Birkbeck (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416052.

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Ibegbu, Augustine. "The effects of hypoxia on neuronal cell signalling." Thesis, Queen Margaret University, 2009. https://eresearch.qmu.ac.uk/handle/20.500.12289/7367.

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Hypoxia adversely affects cells and tissues, and neuronal cells in particular have been shown to be more susceptible to the injurious effects of hypoxia i.e. they may begin to die when oxygen supply is reduced or completely eliminated. Cannabinoid (CB1) receptor and opioid (μ, δ and κ) receptor agonists have been shown to elicit several central nervous system (CNS) effects, mediated via G protein-coupled receptors. The aim of the research presented in this thesis was to study the effect of hypoxia on neuronal cell signalling and the consequent neuroprotectant effects of cannabinoid and opioid

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Lee, Alice Ming Chin. "The effects of synthetic steroids on androgen receptor signalling /." Title page and abstract only, 2005. http://web4.library.adelaide.edu.au/theses/09HS/09hsl4771.pdf.

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Öberg, Anette I. "β-adrenergic signalling and novel effects in skeletal muscle". Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-87205.

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Skeletal muscles have, due to their large mass, a big impact on the whole body metabolism. There are many signals that can regulate the functions of skeletal muscles and one such signal is activation of α- and β-adrenoceptors (α- and β-ARs) by epinephrine and norepinephrine. This activation leads to several effects which are examined in this thesis. Stimulation of β-AR on muscle cells induces glucose uptake, an event that both provides the muscle with energy and lowers the blood glucose levels. We discovered two key components in the β-ARs signal to glucose uptake: the transporter protein GL

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