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Dissertations / Theses on the topic 'Signalling protein MHC Class I'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

Kress, Alla. "Probing molecular orientational order of lipid reporters and MHC Class I protein in cell membranes using polarization-resolved fluorescence imaging." Thesis, Aix-Marseille 3, 2011. http://www.theses.fr/2011AIX30046.

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L'organisation orientationnelle bio-moléculaire des lipides et des protéines dans la membrane plasmique constitue un facteur important dans les processus biologiques au cours desquelles les fonctions peuvent être reliées aux mécanismes d'orientation et d'organisation. Le concept de séparation transitoire des phases à l'échelle nanométrique dans les domaines ordonnés et désordonnés, aussi appelé « radeau lipidique », est maintenant largement accepté. De plus, les domaines ordonnés contiennent des protéines de signalisation, ce qui souligne l'importance des séparations de phase au cours des proc

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2

Persson, Karina. "Structural studies of protein assemblies : MHC class I and lumazine synthase /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5499-9.pdf.

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3

Gruneberg, Ulrike. "The interaction of HLA-DM with conventional MHC class II molecules." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322410.

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4

Bandyopadhyay, Arunima. "Investigating the binding interactions between peptides and the MHC class II protein I-A(k) /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/8561.

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5

McFarland, Benjamin James. "Dissecting the cooperative energetics of the binding interactions between peptides and MHC class II proteins /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/8540.

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6

Lindgren, Cecilia. "Design and Synthesis of Glycopeptides Targeting the Class II MHC DR4 Protein Associated with Rheumatoid Arthritis." Thesis, Umeå universitet, Kemiska institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-61847.

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7

Ghosh, Shohini. "Analysis of the binding interactions between peptides and the MHC class II protein I-A(d) /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8541.

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8

Parkinson, Michael David James. "The protein machinery in the endocytic pathway required for downregulation of virally ubiquitinated MHC class I." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608859.

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9

Michaëlsson, Jakob. "Decoding NK cell receptor specificity : functional and structural studies of MHC class 1 subcomponents /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-286-8.

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10

Murthy, Venkatesh Locharla. "Three dimensional structure of a human Class II MHC protein HLA-DR1 bound to an endogenous peptide." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/10561.

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11

Geering, Barbara. "Regulation of class IA phosphoinositide 3-kinase signalling enzymes by post-translational modifications, protein interactions and absolute protein expression levels." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445504/.

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Phosphoinositide 3-kinases (PI3Ks) are signal transduction proteins that regulate a wide range of cellular processes. A key subset of PI3Ks are the so-called class IA enzymes consisting of a p85 regulatory and p110 catalytic subunit. While the biological activities of PI3Ks have been investigated in detail, the biochemical mechanism of their regulation is underexplored. We therefore strived to investigate post-translational modifications and absolute protein levels of class IA PI3Ks using electrophoresis and mass spectrometry (MS). We thereby focused on endogenous PI3K subunits and physiologic

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12

Sundbäck, Maria. "Vaccine strategies based on mycobacterial heat shock protein 65 /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-465-8.

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13

Painter, Corrie A. "Conformational Lability in MHC II Proteins: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/539.

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MHC II proteins are heterodimeric glycoproteins that form complexes with antigenic peptides in order to elicit a CD4+ adaptive immune response. Even though there have been numerous MHC II-peptide crystal structures solved, there is little insight into the dynamic process of peptide loading. Through biochemical and biophysical studies, it has been shown that MHC II adopt multiple conformations throughout the peptide loading process. At least one of these conformations is stabilized by the MHC II-like homologue, HLA-DM. The main focus of this thesis is to elucidate alternate conformers of MHC II

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14

Parasar, Parveen. "Determination of the Expression Patterns of Bovine Non-Classical Major Histocompatibility Complex (MHC) Class I Proteins." DigitalCommons@USU, 2013. http://digitalcommons.usu.edu/etd/1999.

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My dissertation hypothesis is that bovine trophoblast cells express cell-surface and secreted non-classical major histocompatibility complex class I (MHC-Ib) proteins which inhibit NK cells and other leukocytes by binding to inhibitory receptors (e.g., LILRB1, LILRB2, KIR2DL4, and/or CD94/NKG2A). Extremely polymorphic and ubiquitously expressed classical MHC class I (MHC-Ia) proteins, which present foreign antigenic peptides to CD8+ T lymphocytes, are involved in acceptance or rejection of tissue grafts. Non-classical MHC class I (MHC-Ib) glycoproteins, such as Human Leukocyte Antigen-G (HLA-G

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15

Molano, Alberto. "Peptide binding, TCR recognition and intrathymic positive selection : by an MHC H-2Kb class I molecule devoid of the central anchor ("c") pocket /." Access full-text from WCMC, 1998. http://proquest.umi.com/pqdweb?did=733066101&sid=11&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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16

Charrette, Andrew. "The Role of the Central Region of the Third Intracellular Loop of D1-Class Receptors in Signalling." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23080.

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The D1-class receptors (D1R, D5R) each possess distinct signaling characteristics; however, pharmacological selectivity between them remains elusive. The third intracellular loops (IL3) of D1R and D5R harbour divergent residues that may contribute to their individual signalling phenotypes. Here we probe the function of central region of IL3 of D1R and D5R using deletion mutagenesis. Radioligand binding and whole cell cAMP assays suggest that the N-terminal and C-terminal moieties of the central IL3 oppositely contribute to the constitutive and agonist-dependant activity of D1-Class receptors

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17

Yang, Tianyu. "Two novel mechanisms of MHC class I down-regulation in human cancer accelerated degradation of TAP-1 mRNA and disruption of TAP-1 protein function /." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1078192113.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains x, 117 p.; also includes graphics (some col.) Includes bibliographical references (p. 99-117). Available online via OhioLINK's ETD Center

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18

Hahn, Sabine [Verfasser], and Ulrich [Akademischer Betreuer] Schubert. "Targeting the human immunodeficiency virus type-1 Gag protein into the defective ribosomal product pathway enhances its MHC class I antigen presentation / Sabine Hahn. Betreuer: Ulrich Schubert." Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2011. http://d-nb.info/1015782078/34.

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19

Andersson, Katja. "Intercellular protein transfer and regulation of inhibitory NK cell receptor accessibility /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-183-8/.

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20

Palma, Mariana de Lucena. "Avaliação do fator CIITA como potencial adjuvante molecular para vacinas e imunoterapias." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-24022016-153016/.

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O fator CIITA é a proteína responsável por controlar a transcrição de genes do complexo principal de histocompatibilidade de classe II (MHC II) envolvidos na apresentação antigênica a linfócitos T CD4+. A expressão desta proteína é complexa e célula-específica, dependendo de mecanismos de regulação transcricionais e póstranscricionais. Com o intuito de investigar o potencial do fator CIITA como adjuvante molecular, no presente estudo desenvolvemos e validamos sistemas de transferência gênica capazes de promover a eficiente expressão de CIITA em vários tipos celulares. Além disso, investigamos

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21

Humphrey, Peter Saah. "Signal transduction mechanisms for stem cell differentation into cardiomyocytes." Thesis, University of Hertfordshire, 2009. http://hdl.handle.net/2299/3760.

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Cardiovascular diseases are among the leading causes of death worldwide and particularly in the developed World. The search for new therapeutic approaches for improving the functions of the damaged heart is therefore a critical endeavour. Myocardial infarction, which can lead to heart failure, is associated with irreversible loss of functional cardiomyocytes. The loss of cardiomyocytes poses a major difficulty for treating the damaged heart since terminally differentiated cardiomyocytes have very limited regeneration potential. Currently, the only effective treatment for severe heart failure i

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22

Granados, Diana Paola. "Effect of the unfolded protein response on MHC class I antigen presentation." Thèse, 2008. http://hdl.handle.net/1866/7632.

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23

Lin, Ju-Yin, and 林如愔. "Down-regulation of Human MHC Class II by Epstein-Barr virus Latent Membrane Protein 2A." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/24339185028502842483.

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碩士<br>國立臺灣大學<br>微生物學研究所<br>98<br>The presentation of peptides to CD4+ T cells by MHC class II molecules is of critical importance in specific recognition to a pathogen by the immune system. The level of MHC class II directly influences T lymphocyte activation. Activated CD4+ T cells can produce antiviral cytokines or co-ordinate antiviral immune responses. Viruses escape detection by CD4+ T cells by at least two mechanisms, inhibiting the expression of MHC class II genes and the antigen presentation pathway. Epstein-Barr virus (EBV) is an oncogenic gamma-herpesvirus that persistently infects

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24

Chen, Yuzhi. "Simian virus 40 signalling promotes viral entry to caveolae andmAb against MHC class I induces adhesion of fibroblasts to T cells." 1997. https://scholarworks.umass.edu/dissertations/AAI9809317.

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Simian virus 40 (SV40) entry through caveolae represents a novel form of endocytosis. SV40 translocation to caveolae was mainly examined by cell fractionation and electron microscopy (EM) in CV-1 African green monkey kidney fibroblast cells. SV40 translocated to the caveolin-enriched low density Triton-insoluble complexes as identified by Western blotting. SV40 partitioning into this fraction was inhibited by nystatin. EM analysis indicated that SV40 translocation to caveolae was prevented by the tyrosine kinase inhibitor genistein (thin sections), but SV40 was not blocked from entering the Tr

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25

Zhang, Yinan. "Functional Analysis of the Thiol Oxidoreductase ERp57 and its Role in the Biogenesis of MHC Class I Molecules." Thesis, 2009. http://hdl.handle.net/1807/19120.

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Class I major histocompatibility complex molecules present antigenic peptides to cytotoxic T lymphocytes, which leads to the elimination of virus infected cells. Class I molecules are heterotrimers consisting of a heavy chain, a light chain termed beta2-microglobulin, and a peptide ligand. Assembly of class I molecules begins in the endoplasmic reticulum where the heavy chain associates with beta2-microglobulin, and the heavy chain-beta2-microglobulin heterodimers enter a peptide loading complex where class I molecules acquire peptides. During the biogenesis of class I molecules, ERp57, a thio

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26

Zadražil, Zdeněk. "Charakterizace imunitního systém s využitím MHC II/ EGFP knock-in myši." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-304812.

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The immune system is essential for keeping the integrity of multicellular organisms. We were able to make a step forward in studying the complex immune reactions in mammals in vivo and/ or in situ using the major histocompatibility complex (MHC) class II/ enhanced green fluorescent protein (EGFP) knock-in mouse model. Due to the EGFP visualization of MHC II expressing cells we were able to observe antigen presenting cells, which are essential for the onset of immune responses, in their natural environment. Thus, we report some original features of the immune system. We have identified MHC II+

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27

Huang, Shih-Yin, and 黃詩穎. "The Alteration of Placental-Derived Soluble MHC Class I Chain-Related Protein A and B during Pregnancy and the Influence of Amniotic Fluid on Activated Mononuclear Cell TH1/TH2 Cytokine Production." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/16020805472738180362.

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碩士<br>國立臺灣大學<br>分子醫學研究所<br>97<br>The survival of the semi-allogeneic fetus which can escape from the maternal immune attack during human normal pregnancy is a special immunological phenomenon. Several hypothetical mechanisms are proposed to explain these particular modifications of the immune status of the mother. Lucia Mincheva-Nilsson et al. (2006) suggested a new physiological mechanism for fetal evasion from maternal immune attack in that the engagement and down-regulation of the NK cell receptor NKG2D by soluble MHC class I chain-related proteins (sMIC) A and B derived from placenta occur

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28

Deffit, Sarah N. "A role for HSC70 in regulating antigen trafficking and presentation during macronutrient deprivation." Thesis, 2015. http://hdl.handle.net/1805/6595.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Globally, protein malnutrition remains problematic, adversely affecting several systems including the immune system. Although poorly understood, protein restriction severely disrupts host immunity and responses to infection. Induction of high-affinity, long-lasting immunity depends upon interactions between B and T lymphocytes. B lymphocytes exploit several pathways including endocytosis, macroautophagy, and chaperone-mediated autophagy to capture and deliver antigens to the endosomal network. Within the endosomal network antigens ar

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