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Dissertations / Theses on the topic 'Signalosomes'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Abdessamad, Mahmoud. "Caractérisation moléculaire et fonctionnelle des signalosomes PTEN/MAGI-1b/TRIP6 et PTEN/PTPN13." Paris 7, 2012. http://www.theses.fr/2012PA077048.

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Le suppresseur de tumeurs PTEN est une phosphatase capable de déphosphoryler certains résidus tyrosine, mais également les phosphoinositides produits de la PI3K. Dans son extrémité C- terminale, PTEN comporte un motif d'interaction avec les domaines PDZ. Notre équipe a établi le rôle majeur de l'activité lipide-phosphatase dans la stabilisation des contacts cellulaires et le contrôle de l'invasion. PTEN est recruté vers les jonctions cellulaires E-cadhérine β-caténine, via la molécule à domaines PDZ MAGI-1. Afin d'identifier de nouveaux partenaires de PTEN, nous avons engagé une approche par l

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2

Enchev, Radoslav Ivanov. "Structural Studies of the C0P9 Signalosome." Thesis, Institute of Cancer Research (University Of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521848.

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3

Birol, Melissa. "Le COP9 signalosome : activité et régulation." Thesis, Montpellier 2, 2014. http://www.theses.fr/2014MON20072/document.

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Le COP9 (Constitutive photomorphogenesis 9) signalosome (CSN) est un complexe multiprotéique contenant huit sous-unités (320 kDa), impliqué dans des processus cellulaires divers allant de la progression du cycle cellulaire, à l'expression des gènes et la réparation de l'ADN, à travers sa fonction au sein du système ubiquitine-protéasome. Il s'agit d'un complexe fortement conservé au cours de l'évolution chez les eucaryotes supérieurs chez qui son activité catalytique est essentielle. Au cours des années d'études biologiques et biochimiques qui ont permis d'élucider le rôle du CSN, sa fonction

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4

Peth, Andreas. "Funktionelle Charakterisierung der Interaktion des COP9-Signalosoms mit dem Mikrotubuli-bindenden Protein EB1." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2007. http://dx.doi.org/10.18452/15686.

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Das COP9-Signalosom (CSN) ist ein evolutionär konservierter Proteinkomplex. Er besteht aus acht Untereinheiten und wird als Paralog des Lid-Subkomplexes des 26S Proteasoms angesehen. Das CSN verfügt über diverse enzymatische Aktivitäten, die es zu einem regulatorischen Faktor des Ubiquitin-Proteasom-Systems (UPS) machen. Das UPS ist für den Abbau von einem Großteil der zellulären Proteine notwendig. Für die Proteolyse bestimmter Proteine werden diese mit einer Polyubiquitinkette markiert. Dies geschieht über eine Enzymkaskade von E1, E2s und E3-Ligasen, wobei die E3s die Substratspezifität bes

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5

Leppert, Ulrike. "Die Biogenese des COP9 Signalosoms wird durch microRNAs der let-7-Familie reguliert." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16224.

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Das COP9 Signalosom ist ein hochkonservierter Proteinkomplex bestehend, aus acht Untereinheiten. In der vorgelegten Promotionsarbeit konnte ein bislang unbekannter Regulationsmechanismus der Biogenese des COP9 Signalosoms identifiziert werden. Die siRNA-vermittelte Reduktion der CSN1-Expression führte zu einer Reduktion der Expression aller CSN-Untereinheiten. Die Transfektion von His-CSN1 in siCSN1-Zellen induzierte die CSN-Neusynthese und ferner einen Anstieg der c-Myc- und STAT1 Expression. Durch die Stimulation der Zellen mit IFN alpha bzw. IFN gamma konnte die de novo Synthese des CSN-Kom

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6

Dohmann, Esther Mirjam Natascha. "The role of the Arabidopsis COP9 signalosome in plant development /." Tübingen, 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000276828.

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7

Busch, Silke. "Amino Acid Biosynthesis and the COP9 Signalosome in Aspergillus nidulans." Doctoral thesis, [S.l.] : [s.n.], 2002. http://hdl.handle.net/11858/00-1735-0000-0006-AE62-6.

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8

Khatamzas, Elham. "Definition of the early HIV-1 signalosome in dendritic cells." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:e504a1b9-f8c0-455e-a61b-27c29b5adcdf.

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DCs are critical to the early events of HIV-1 infection. They are the first cells that HIV-1 encounters at mucosal surfaces and as sentinel antigen-presenting cells of the immune system these should alarm the immune system and activate innate immune defences to recruit effective adaptive immunity and viral clearance. A peculiar characteristic of HIV – in contrast to other ssRNA viruses – is its ability to completely evade host innate recognition pathways. Additionally, it has the unique ability to manipulate the endo-lysosomal system of DCs and promote transmission via trans-infection to CD4+

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9

Leblond-Castaing, Julie. "Caractérisation de l’interaction des protéines IMA/MIF2 et CSN5 au niveau moléculaire et physiologique." Thesis, Bordeaux 1, 2011. http://www.theses.fr/2011BOR14466/document.

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Les plantes ont la capacité à former de nouveaux organes grâce à une croissance continue assurée par une réserve de cellules souches au sein de structures spécifiques, les méristèmes. Les méristèmes floraux diffèrent des méristèmes végétatifs par leur caractère déterminé aboutissant à la production des fleurs. Le gène IMA (INHIBITOR OF MERISTEM ACTIVITY) code une protéine contenant un motif «doigt à zinc» (MIF) régulant les processus développementaux de la fleur et des ovules chez la tomate. En effet, IMA inhibe la prolifération cellulaire au cours de la terminaison florale en agissant sur l’e

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10

Hetfeld, Bettina Kathrin Johanna. "Die Funktionen des COP9-Signalosoms und des assoziierten USP15 im Ubiquitin-Proteasomsystem." Doctoral thesis, [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980671868.

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11

Asare, Yaw [Verfasser]. "Role of the COP9 signalosome and IKK complexes in Atherosclerosis / Yaw Asare." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2013. http://d-nb.info/1044570229/34.

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12

Herron, John Paul. "Immunoaffinity isolation of Btk´s signalosome, a proteomic approach to identifying interacting proteins." Thesis, Södertörn University College, School of Life Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-1114.

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<p>The Signalosome is a term used to define a putative signalling complex, which assembles near the plasma membrane in response to external signals received at cell surface receptors and then migrates towards downstream effectors. It is proposed to regulate the level of intracellular Ca2+ and subsequent downstream signalling events. To date it has been defined to consist of BTK, BLNK, BCAP, VAV, PLCγ2 and PI3K1-4 in B-Cells.</p><p>This work entailed initiating a new proteomic approach to investigate the nature and extent of Bruton’s tyrosine kinase, Btk, involvement in the signalosome – inhere

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13

Gill, Stephen George. "Characterisation of the COP9 signalosome (CSN) using Caenorhabditis elegans as an experimental system." Thesis, University of Sussex, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418716.

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14

Brockway, Heather Marie. "A role for the CSN/COP9 signalosome in synaptonemal complex assembly and meiotic progression." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/1296.

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Defects in meiotic prophase I events, resulting in aneuploidy, are a leading cause of birth defects in humans; however, these are difficult to study in mammalian systems due to their occurrence very early in development. The nematode, Caenorhabditis elegans, is an excellent model for prophase I studies as its gonad is temporally and spatially organized around these meiotic events. Homolog pairing, synapsis, meiotic recombination and crossover formation are essential to the proper segregation of chromosomes into the respective gametes, either the egg or sperm. Disturbances in these events leads

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15

Berse, Matthias. "Regulation der Stabilität der proangiogenen Transkriptionsfaktoren c-Jun, Id1 und Id3 durch das COP9-Signalosom." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2006. http://dx.doi.org/10.18452/15399.

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Für die Progression des Wachstums maligner Tumoren und ihre Metastasierung ist die Angiogenese, die Bildung neuer Blutgefäße aus bereits existierenden, eine essentielle Voraussetzung. In dieser Arbeit konnte gezeigt werden, dass die proangiogenen Transkriptionsfaktoren c-Jun, Id1 und Id3 in ihrer Stabilität gegenüber dem Ubiquitin/26S-Proteasom-System durch das COP9-Signalosom (CSN) kontrolliert werden. Dieses bildet einen multimeren Proteinkomplex, der deutliche Homologien mit dem Lid-Subkomplex des 26S-Proteasoms aufweist. Sowohl c-Jun als auch Id3 binden an die Untereinheit CSN5. Id3 inter

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16

Uhle, Stefan. "Identifizierung und Charakterisierung von Enzymen, die mit dem COP9 Signalosom assoziiert sind." [S.l. : s.n.], 2004. http://www.diss.fu-berlin.de/2004/244/index.html.

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17

Mecha, Ezekiel Onyonka [Verfasser]. "Characterization of the TGF-beta signalosome and of TGF-beta-dependent endometrial cell proliferation / Ezekiel Onyonka Mecha." Gießen : Universitätsbibliothek, 2014. http://d-nb.info/1068590459/34.

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18

Feist, Mathilde [Verfasser]. "Die Rolle des COP9 Signalosoms bei der hyperthermen intraperitonealen Chemotherapie : Mögliche Konsequenzen für die Klinik / Mathilde Feist." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2014. http://d-nb.info/1052530257/34.

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19

Powell, Kelly Ann. "The Schizosaccharomyces pombe Ribonucleotide Reductase enzyme is regulated by the DNA integrity checkpoint and the COP9/Signalosome." Thesis, University of Sussex, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393211.

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20

Jong, Sarah Jill de [Verfasser], and Lars [Akademischer Betreuer] Nitschke. "Dissecting the Tio-NF-kappaB Signalosome in Human T Cells / Sarah Jill de Jong. Betreuer: Lars Nitschke." Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2011. http://d-nb.info/1015782094/34.

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21

Pearce, Claire. "COP9 signalosome subunit knockdown in K562 provides novel insight into the function and potential regulation of the CSN." Thesis, University of Birmingham, 2009. http://etheses.bham.ac.uk//id/eprint/427/.

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The co-ordinated degradation of proteins is vital to all aspects of cellular activity. The main mechanism of intracellular protein degradation is the ubiquitin proteasome system (UPS) which labels target proteins with ubiquitin, thereby marking them for degradation by the 26S proteasome. Protein ubiquitination is mediated by three enzymes; E1, E2, E3. The largest family of E3’s is the cullin-RING E3 ubiquitin ligases (CRLs). CRLs require the cyclic addition and removal of a ubiquitin-like protein called NEDD8 to and from the cullin subunit. Removal of NEDD8 (deneddylation) is mediated by the e

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22

Gummlich, Linda. "The CSN-CRL pathway and two p27kip1 mutants in renal cancer cells." Doctoral thesis, Humboldt-Universität zu Berlin, 2017. http://dx.doi.org/10.18452/18044.

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Nierenzellkarzinome (RCC) gehören zu den häufigsten malignen Tumoren weltweit. Aufgrund der alarmierend hohen Inzidenz- und Sterberate besteht ein dringender Bedarf an neuen therapeutischen Targets zur Behandlung von RCCs. Punktmutationen in der Codesequenz von Proteinen führen zu einer Anhäufung von fehlgefalteten Proteinen in Tumorzellen und erfordern eine stärkere Kontrolle der Proteinqualität. Das Ubiquitin-Proteasome-System (UPS) bietet daher ein ideales therapeutisches Target für die RCC Therapie. Aktuelle Veröffentlichungen deuten auf eine Deregulation des COP9 Signalosome (CSN)-Cullin-

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23

Georgiakaki, Maria. "Mécanisme d'action du récepteur de la progestérone : modulation par les cofacteurs JAB1 et HBO-1." Paris 6, 2003. http://www.theses.fr/2003PA066136.

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24

Tumini, E. "PSF2 and COPS3 are novel interactors of the Fanconi anemia core complex." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/158339.

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Fanconi anemia (FA) is a congenital disease characterized by bone marrow failure, increased cancer risk and hypersensitivity to DNA cross-linking agents, implying a role for this pathway in the maintenance of genomic stability. The central player of the FA pathway is the multi-subunit E3 ubiquitin ligase complex that is activated through a replication and DNA-damage dependent mechanism. A consequence of the activation of the complex is the monoubiquitination of FANCD2 and FANCI, late term effectors in the maintenance of genome integrity. We find that PSF2 and CSN3 interact with the core comple

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25

Mir, Moreno Ricardo. "Caracterización molecular y funcional del gen PATHOGEN AND CIRCADIAN CONTROLLED 1 (PCC1) en Arabidopsis thaliana." Doctoral thesis, Universitat Politècnica de València, 2013. http://hdl.handle.net/10251/29751.

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Las plantas son capaces de modificar los patrones de desarrollo tras percibir ciertos tipos de estrés. En Arabidopsis, se identificó PCC1 como un regulador positivo de la transición floral en respuesta al estrés generado por irradiación con luz UV-C. El análisis de plantas transgénicas pPCC1::GUS muestra que PCC1 se expresa durante los primeros días de desarrollo en estomas y haces vasculares de cotiledones. En hojas verdaderas en formación se detecta tinción GUS en su parte basal, incluyendo los haces vasculares, y se va extendiendo completamente a toda la superficie de hojas com

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Borgmann, Marc [Verfasser], та Michael [Akademischer Betreuer] Naumann. "Molekulare Charakterisierung der Interaktion des COP9-Signalosoms mit NF-[Kappa]B/RelA und I[Kappa]Bα / Marc Borgmann. Betreuer: Michael Naumann". Magdeburg : Universitätsbibliothek, 2014. http://d-nb.info/1066295298/34.

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Hoareau, Alves Karine. "Etude fonctionnelle de la protéine Int-6 et caractérisation de ses interactions avec eIF3, le protéasome 26S et le COP9 Signalosome." Lyon, École normale supérieure (sciences), 2003. http://www.theses.fr/2003ENSL0262.

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Tanguy, Gaëlle. "Rôle des interactions moléculaires dans le processus de maturation de la protéine CFTR : implications de CSN5 et de la voie du signalosome." Paris 12, 2007. https://athena.u-pec.fr/primo-explore/search?query=any,exact,990003375620204611&vid=upec.

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La mucoviscidose, maladie génétique la plus fréquente dans les populations d’origine caucasienne, résulte de mutations dans le gène codant la protéine CFTR (Cystic Fibrosis Transmembrane conductance Regulator). La plus fréquente des mutations de CFTR est une délétion du codon correspondant à la phénylalanine 508 (F508del) qui est à l’origine d’un adressage défectueux et d’une fonction altérée de la protéine. L’objectif de ce travail a été d’identifier des protéines interagissant avec CFTR et pouvant jouer un rôle dans son adressage, son recyclage à la membrane ou sa fonction. Pour cela, un cri

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Bhansali, Meenakshi. "Exploring the Roles of TM4SF3 and CSN4 in Prostate Cancer." University of Toledo / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1408699883.

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Calligé, Mathilde. "Mécanismes de dégradation du récepteur des oestrogènes alpha." Toulouse 3, 2004. http://www.theses.fr/2004TOU30087.

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Le récepteur des oestrogènes (REa) est un facteur de transcription actif lorsqu'il est lié à son ligand naturel, l'oestradiol. Mes travaux de thèse ont mis en évidence des mécanismes d'action distincts pour deux antagonistes des oestrogènes, un antagoniste partiel l'OH-Tamoxifène (OH-Tam) et un antagoniste pur l'ICI 182 780 (ICI). Le REa complexé à l'OH-Tam est capable de remodeler la chromatine du promoteur du gène oestrogéno-régulé pS2/TFF1 dans des cellules cancéreuses mammaires hormono-dépendantes sans induire la transcription. Par contre, l'ICI induit une rapide relocalisation du REa dans

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Fontes, Adriana Filipa da Silva. "Mitochondrial defects in proteasome and COP9 mutants." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13273.

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Mestrado em Biotecnologia - Biotecnologia Molecular<br>The aim of this work is the study of phenotypic changes and mitochondrial morphology in Saccharomyces cerevisiae cells with specific mutations in genes involved in the ubiquitin-proteasome pathway. The protein turnover is important because it ensures organelles viability such as mitochondria, indispensable for cell survival. The COP9 complex is paralogous to the proteasome lid and eukaryotic translational initiator factor 3 (eIF3) complexes. The CSN5 subunit of the COP9 signalosome is responsible for the E3 ligase Cdc53/Cul1 activi

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Heine, Andreas [Verfasser]. "Einfluss des Monomers TEGDMA als Bestandteil dentaler Composite auf das COP9 Signalosom und die Differenzierung von LiSa-2 Zellen / Andreas Heine." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1126503584/34.

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Schramm, Andreas [Verfasser], and Lotte [Akademischer Betreuer] Søgaard-Andersen. "Characterization of the Esp signalosome: Two hybrid histidine kinases utilize a novel signaling mechanism to regulate developmental progression in Myxococcus xanthus / Andreas Schramm. Betreuer: Lotte Søgaard-Andersen." Marburg : Philipps-Universität Marburg, 2013. http://d-nb.info/1032312777/34.

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34

Christmann, Martin [Verfasser], Gerhard [Akademischer Betreuer] Braus, Ralf [Akademischer Betreuer] Ficner, and Peter [Akademischer Betreuer] Rehling. "Deneddylation and fungal development - Regulation of Nedd8 protein modification by DenA and the COP9 signalosome / Martin Christmann. Gutachter: Gerhard Braus ; Ralf Ficner ; Peter Rehling. Betreuer: Gerhard Braus." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://d-nb.info/1042529523/34.

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Jumpertz, Sandra Verfasser], Jürgen [Akademischer Betreuer] Bernhagen, and Joost T. van [Akademischer Betreuer] [Dongen. "Functional Role of the COP9 Signalosome in Colorectal Cancer and Intestinal Homeostasis:Mechanistic Links to Cancerogenic Signaling Pathways in the Gut / Sandra Jumpertz ; Jürgen Bernhagen, Joost Thomas van Dongen." Aachen : Universitätsbibliothek der RWTH Aachen, 2017. http://d-nb.info/1162498714/34.

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Santos, Ana Rita Faria dos. "CD5, a molecular switch regulating signaling at the surface of T cells." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13747.

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Mestrado em Biologia Molecular e Celular<br>T cell receptor recognition of peptide-MHC expressed on antigen presenting cells (APC) involves the formation of a tight cell-cell contact area, named immunological synapse. Upon successful T cell activation, several signal transduction pathways are triggered culminating with the induction of gene transcription. The T cell surface glycoprotein CD5, an inhibitor of TCR signaling, is one of the molecules that targets to the immunological synapse upon T cell activation, although no ligand in the APCs has yet been discovered. We have determined that

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Berse, Matthias [Verfasser], M. [Gutachter] Naumann, R. [Gutachter] Schäfer, and W. [Gutachter] Dubiel. "Regulation der Stabilität der proangiogenen Transkriptionsfaktoren c-Jun, Id1 und Id3 durch das COP9-Signalosom / Matthias Berse ; Gutachter: M. Naumann, R. Schäfer, W. Dubiel." Berlin : Humboldt-Universität zu Berlin, 2006. http://d-nb.info/1208077767/34.

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Meister, Cindy [Verfasser], Gerhard H. [Akademischer Betreuer] Braus, Gerhard H. [Gutachter] Braus, Kai [Gutachter] Tittmann, and Achim [Gutachter] Dickmanns. "Interplay of the COP9 signalosome deneddylase and the UspA deubiquitinase to coordinate fungal development and secondary metabolism / Cindy Meister ; Gutachter: Gerhard H. Braus, Kai Tittmann, Achim Dickmanns ; Betreuer: Gerhard H. Braus." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://d-nb.info/1187520330/34.

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Chapiro, Julius [Verfasser]. "Untersuchungen zur Regulation des Ubiquitin-Proteasom-Systems durch den Makrophagen-Migrations-Inhibitions-Faktor und dessen Interaktoren COP9 Signalosom und p97 in der zellulären Hypoxieantwort / Julius Chapiro." Gießen : Universitätsbibliothek, 2015. http://d-nb.info/1068922729/34.

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40

Lopez, Johanna. "The MAKAPbeta Signalosome Is Involved In Cardiac Myocyte Hypertrophy Through The Recruitment Of Calcineurin Abeta: A Study On How Multimolecular Complexes Are Important For The Integration And Fidelity Of Signal Transduction Behind Cellular And Physiological Responses." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_theses/226.

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Myocyte hypertrophy is the major compensatory response of the heart to chronic stress. It is induced by the activation of a network of interdependent, intracellular signaling pathways.1 An important pathway activated during the hypertrophic response is the calcineurin Abeta-NFATc transcription factor pathway.2 Our laboratory has recently discovered that calcineurin Abeta and NFATc transcription factors can associate with the scaffold protein mAKAPbeta.3 mAKAPbeta is a scaffold protein that forms a multimolecular signalosome located to the nuclear envelope of cardiac myocytes. Preliminary data

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Védrine-Bochard, Valérie. "Étude des interactions entre Int6 et les protéines cellulaires." Lyon, École normale supérieure (sciences), 2001. http://www.theses.fr/2001ENSL0197.

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La protéine Int6 humaine, localisée à la fois dans le noyau et le cytoplasme, a initialement été caractérisée comme une cible de la protéine oncogénique Tax du rétrovirus HTLV-I. La fonction de cette protéine, exprimée à la fois chez S. Pombe, les plantes et les mammifères n’a pas été encore élucidée. Cependant les publications récentes montrent qu’elle est associée à au moins deux complexes multiprotéiques à domaine PCI : le facteur d’initiation de la traduction eIF3, et le signalosome COP9. Mes travaux sur la fonction d’Int6 ont débuté par la réalisation d’un criblage en double hybride dans

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Nahlik, Krystyna. "The COP9 signalosome of Aspergillus nidulans." Doctoral thesis, 2007. http://hdl.handle.net/11858/00-1735-0000-0006-B4EA-B.

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43

Mosadeghi, Ruzbeh. "Mechanistic Dissection of the Cop9 Signalosome’s Deneddylation Activity on Cullin-RING Ligases." Thesis, 2015. https://thesis.library.caltech.edu/8951/1/06122015%20Ruzbeh%20Mosadeghi%20Thesis.pdf.

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<p>We set out to understand the precise mechanisms that regulate the activation and deactivation of Cullin-RING Ligases (CRLs). While a great deal of work has already gone into identifying the players involved in these pathways and the cellular consequences associated with the loss of each, the biochemical mechanisms regulating these steps have remained elusive. In this work we sought to gain a better understanding of the mechanisms behind these steps by teasing apart specific their biochemical reactions. By measuring the individual microscopic rate constants of the reactions we have shed ligh

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Cope, Gregory Allan. "Regulation of SCF ubiquitin ligases by Jab1/Csn5 and the Cop9 signalosome." Thesis, 2006. https://thesis.library.caltech.edu/2964/1/CopeThesis.pdf.

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SCF ubiquitin ligases regulate the ubiquitin-dependent proteolysis of a myriad of substrate proteins, including p27, Cyclin E, and IkBa. To further gain insight into SCF regulation and function, we purified SCF from mammalian cells and found the Cop9 Signalosome associated with SCF. Interestingly, deletion of the CSN in S. pombe resulted in the hypermodification of Cul1 with Nedd8 in vivo. Furthermore, we found that the CSN can promote the removal of Nedd8 from Cul1 in vitro, suggesting CSN regulates SCF through deneddylation. To investigate the basis of CSN-dependent deneddylation activity, w

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Huang, Yi-Chun, and 黃亦君. "The COP9 Signalosome Converts Temporal Hormone Signaling to Spatial Restriction on Neural Competence." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/53134084600333522757.

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博士<br>國防醫學院<br>生命科學研究所<br>103<br>During development, neural competence is conferred and maintained by integrating spatial and temporal regulations. The Drosophila sensory bristles that detect mechanical and chemical stimulations are arranged in stereotypical positions. The anterior wing margin (AWM) is arrayed with neuron-innervated sensory bristles while posterior wing margin (PWM) bristles are non-innervated. We found that the COP9 signalosome (CSN) suppresses the neural competence of non-innervated bristles at the PWM. In CSN mutants, PWM bristles are transformed into neuron-innervated, whi

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Christmann, Martin. "Deneddylation and fungal development - Regulation of Nedd8 protein modification by DenA and the COP9 signalosome." Doctoral thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-000D-EF70-1.

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Chuang, Hsiu-Chun, and 莊琇珺. "Functional characterization of the TRAX –signalosome in mediating the action of the A2A adenosine receptor." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/75350524868353233550.

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碩士<br>國立陽明大學<br>神經科學研究所<br>96<br>The A2A adenosine receptor (A2A-R) is located in many different areas of the brain and has been implicated in a wide variety of neuronal functions. We previously reported that the C terminus of A2A-R binds Translin associated protein X (TRAX). TRAX was first identified as an associating protein of translin, which plays an important role in DNA repair and recombination. We further demonstrated that, via interacting with TRAX, activation of the A2A-R rescued the impairment of nerve growth factor (NGF)-induced neurite outgrowth caused by p53 inhibition in PC12 cel

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Maetzel, Dorothea [Verfasser]. "Identifikation und Validierung EpCAM-assoziierter Interaktionspartner : das EpCAM-Signalosom / Dorothea Maetzel." 2008. http://d-nb.info/989533611/34.

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Peth, Andreas [Verfasser]. "Funktionelle Charakterisierung der Interaktion des COP9-Signalosoms mit dem Mikrotubuli-bindenden Protein EB1 / von Andreas Peth." 2007. http://d-nb.info/986875252/34.

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Sun, Chung Nan, and 孫忠男. "Functional Characterization of the A2AR Rescue Effect on Neuritogenesis through a TRAX-Signalosome dependent Signaling Pathway." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/05004678114920732315.

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博士<br>國防醫學院<br>生命科學研究所<br>98<br>The A2A adenosine receptor (A2AR) is a G protein-coupled receptor. We previously reported that the C-terminus of the A2AR binds to translin-associated protein X (TRAX) and modulates nerve growth factor (NGF)-evoked neurite outgrowth in PC12 cells. Herein, I show that neuritogenesis of primary hippocampal neurons requires p53 because blockage of p53 suppressed neurite outgrowth. The impaired neuritogenesis caused by p53 blockage was rescued by activation of the A2AR (designated the A2A rescue effect) in a TRAX-dependent manner. Importantly, suppression of a TRAX-

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