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1

United States International Trade Commission. The economic effects of significant U.S. imports restraints: [investigation no. 332-325]. The Commission, 1993.

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United States International Trade Commission. The economic effects of significant U.S. import restraints: [investigation no. 332-325]. The Commission, 1999.

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3

Miemczyk, J. The evaluation of significant environmental effects by UK organisations implementing environmental management systems. Oxford Brookes University, 1996.

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4

National Academies Press (U.S.), ed. Marine mammal populations and ocean noise: Determining when noise causes biologically significant effects. National Academies Press, 2005.

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5

Carrigan, James T. The origins and effects of shame and guilt on those bereaved by the suicide of a significant other. The Author], 1997.

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6

Hansen, Peter Reinhard. Testing the significance of calendar effects. Federal Reserve Bank of Atlanta, 2005.

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7

Associates, W/L, Maryland. Dept. of Natural Resources., and Public Service Commission of Maryland., eds. Status report of current biological, medical, and engineering research, and significant study results regarding potential human health effects associated with power frequency, electric, and magnetic fields: Reporting period, May 1989-August 1990. Dept. of Natural Resources, Energy Administration, Power Plant and Environmental Review Division, 1990.

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8

Commission, United States International Trade. The economic effects of significant U.S. import restraints: Report to the Committee on Finance of the United States Senate on investigation no. 332-262 under section 332 of the Tariff Act of 1930. U.S. International Trade Commission, 1990.

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9

Office, General Accounting. Aviation and the environment: Aviation's effects on the global atmosphere are potentially significant and expected to grow : report to the Honorable James L. Oberstar, Ranking Democratic Member, Committee on Transportation and Infrastructure, House of Representatives. The Office, 2000.

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10

Office, General Accounting. Aviation and the environment: Aviation's effects on the global atmosphere are potentially significant and expected to grow : report to the Honorable James L. Oberstar, Ranking Democratic Member, Committee on Transportation and Infrastructure, House of Representatives. The Office, 2000.

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11

T, Carrington Patricia, ed. Entrepreneurship and its economic significance, behavior and effects. Nova Science Publishers, 2009.

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12

Bradshaw, Maria V., and Patricia T. Carrington. Entrepreneurship and its economic significance, behavior and effects. Nova Science Publishers, 2009.

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13

1958-, Ruda Harry E., and Boucher Yang G, eds. Cambridge illustrated handbook of optoelectronics and photonics: An illustrated encyclopedic dictionary of significant terms, effects, phenomena, equations, and properties, from fundamental concepts to applications, from materials to devices to systems, covering optoelectronics and photonics, including optical communications. Cambridge University Press, 2009.

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14

Poggio, Pier Paolo. La crisi ecologica: Origini, rimozioni, significati. Jaca Book, 2003.

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15

Lyndon B. Johnson Space Center., ed. Fluid-electrolyte responses during prolonged space flight: A review and interpretation of significant finds. National Aeronautics and Space Administration, Lyndon B. Johnson Space Center, 1985.

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Lyndon B. Johnson Space Center., ed. Fluid-electrolyte responses during prolonged space flight: A review and interpretation of significant finds. National Aeronautics and Space Administration, Lyndon B. Johnson Space Center, 1985.

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17

United States International Trade Commission, ed. An Introduction to the ITC computable general equilibrium model: Addendum to the Economic effects of significant U.S. import restraints : report to the Committee on Finance of the United States Senate, on investigation no. 332-262 under Section 332 of the Tariff Act of 1930. U.S. International Trade Commission, 1991.

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18

Thinnes, Gary L. Significance of in-structure generated motion in seismic qualification tests of cabinet mounted electrical devices. Division of Engineering, Office of Nuclear Regulatory Research, U.S. Nuclear Regulatory Commission, 1988.

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19

Thinnes, Gary L. Significance of in-structure generated motion in seismic qualification tests of cabinet mounted electrical devices. Division of Engineering, Office of Nuclear Regulatory Research, U.S. Nuclear Regulatory Commission, 1988.

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20

Mackie, Peter, John Nellthorp, and James Laird. Projects with Significant Expected Restructuring Effects. World Bank, Washington, DC, 2005. https://doi.org/10.1596/11804.

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21

Arce, Hugh M. Economic Effects of Significant U.S. Import Restraints: Third Update. Diane Pub Co, 2003.

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22

Tabak, John. Significant Gestures. Praeger, 2006. http://dx.doi.org/10.5040/9798216014669.

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Tabak has created a fascinating exploration of a unique and uniquely beautiful North American language. The story begins in 18th century France in the first schools to use signed language as the language of instruction. Early in the 19th century a few individuals introduced a variant of this language into the United States and developed an educational system in which to use it. Out of these schools come members of a new American social class, the Deaf—with a capital D—who, united by a common signed language, create institutions through which they can participate in society on terms equal to th
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23

Marine Mammal Populations and Ocean Noise: Determining When Noise Causes Biologically Significant Effects. National Academy Press, 2005.

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24

Committee on Characterizing Biologically Significant Marine Mammal Behavior, Ocean Studies Board, Division on Earth and Life Studies, and National Research Council. Marine Mammal Populations and Ocean Noise: Determining When Noise Causes Biologically Significant Effects. National Academies Press, 2005.

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25

(US), National Research Council. Marine Mammal Populations And Ocean Noise: Determining When Noise Causes Biologically Significant Effects. National Academy Press, 2005.

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26

Committee on Characterizing Biologically Significant Marine Mammal Behavior, Ocean Studies Board, Division on Earth and Life Studies, and National Research Council. Marine Mammal Populations and Ocean Noise: Determining When Noise Causes Biologically Significant Effects. National Academies Press, 2005.

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27

Hayhow, Bradleigh, and Sergio Starkstein. Biological Effects of Depression. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190603342.003.0005.

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This chapter examines the bidirectional relationship between depression and stroke. It is now clearly established that depression is a significant risk factor for stroke, and vice-versa. We review the main biological and demographic factors underlying the association between stroke and depression, the predicted mortality, the mechanism of post-stroke depression, and recent findings on its pharmacological prevention. We conclude by stressing the need for developing effective strategies to manage the burden of illness associated with these interacting conditions. As with the cardiovascular syste
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28

Tracy, Derek K., and Fiona Gaughran. Treatment with medication: Side effects, adherence, and risk. Edited by Alec Buchanan and Lisa Wootton. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198738664.003.0009.

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Antipsychotic medications revolutionized the care of psychosis, but they have brought with them significant side effects and issues around adherence; these latter factors, and informed co-working with patients, are primary drivers for specific medication choices. The data remain limited for polypharmacy and above-maximum dose prescribing, though there may be individuals for whom this is considered. Long-acting injectables (LAIs or ‘depots’) have a good evidence base, and are probably underutilized, though clozapine remains our drug of choice in refractory illness. Forensic-population data show
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29

Doyle, Lauren R., and Sarah N. Mattson. Behavioral Teratogenic Effects of Alcohol: Focus on Neurobehavioral Disorder Associated With Prenatal Alcohol Exposure. Edited by Thomas H. Ollendick, Susan W. White, and Bradley A. White. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780190634841.013.39.

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Prenatal exposure to teratogens may alter fetal development and significantly impact later life. Perhaps the best known teratogen is alcohol; prenatal alcohol exposure causes a broad range of effects that can cause lifelong impairment. Of greatest significance are the functional impairments in behavior and cognition. Recognition of these impairments led to the inclusion of the neurobehavioral disorder associated with prenatal alcohol exposure (ND-PAE) in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders under “conditions for further study.” This proposed diagnosis
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30

Herren, Cherie L., and Rana R. Said. Preventing Side Effects and Diet Discontinuation. Edited by Eric H. Kossoff. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0010.

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Generally, the ketogenic diet is well tolerated. On average, sixty percent of patients remain on the diet for over six months; those who stop typically do so due to lack of efficacy rather than tolerability. Common side effects include constipation, vomiting, acidosis, and vitamin/mineral deficiencies. More significant side effects are rare, but include pancreatitis, hepatitis, kidney stones, and cardiomyopathy. With appropriate monitoring and supplementation, these adverse effects can be minimized so the patient can remain on the diet as long as indicated. In addition, there may be social iss
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31

Olex, Stephen, and Krista Olex. Effects of Exercise on Mental Health. Edited by Anthony J. Bazzan and Daniel A. Monti. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190690557.003.0003.

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While the beneficial effects of exercise on the body are well established, there is now substantial evidence that physical activity has significant benefits on brain function and mental health as well. Physical activity including aerobic exercise, resistance exercise, yoga, and Tai Chi can influence mental health through numerous mechanisms on multiple levels, ranging from the microscopic to the level of human connection. A large body of clinical data suggests that exercise has beneficial effects on mood and cognition. While the evidence is strongest for the effects of aerobic exercise on cogn
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32

Abhishek, Abhishek, and Michael Doherty. Placebo, nocebo, and contextual effects. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0027.

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Placebo effect is an example of ‘contextual’ effect and is the symptomatic improvement experienced by patients who have unknowingly received a placebo (inactive treatment) instead of an active drug. It occurs due to patient-specific factors such as expectation of improvement and is influenced by the context in which the treatment is delivered. Nocebo effect is the opposite of placebo effect and includes worsening of symptoms or incident adverse effects due to expectancy or negative contextual or practitioner influence. Placebo effect has been demonstrated in a range of musculoskeletal conditio
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33

Ward, L. Monique, Rita Seabrook, Soraya Giaccardi, and Angie Zuo. Television Uses and Effects in Emerging Adulthood. Edited by Jeffrey Jensen Arnett. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199795574.013.26.

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Even though media platforms have multiplied in recent years, television viewing remains a prominent feature of the daily lives of emerging adults. The genres preferred and motivations for viewing are diverse, and many emerging adults report watching TV for relaxation, entertainment, and voyeurism. Despite their reasons for doing so, regular viewing of mainstream television content has many implications for emerging adults’ development. In this chapter, the authors review more than 150 studies that have examined television uses and effects among emerging adults. Overall, data gathered across bo
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34

Reading, Paul J. Neurological diseases and their effects on the sleep–wake cycle. Edited by Sudhansu Chokroverty, Luigi Ferini-Strambi, and Christopher Kennard. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199682003.003.0035.

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This chapter addresses current neurobiological knowledge of how wake- and sleep-promoting systems interact to produce the daily circadian rhythm of wake and sleep and how this may be adversely affected by a variety of neurological diseases. The crucial importance of sleep quality for optimal brain function is stressed and the potential hazards of prolonged wakefulness highlighted. Insomnia relating to either sleep onset or maintenance is common and increases with normal aging. Many neurodegenerative diseases such as Alzheimer disease appear to enhance the effects of aging on the sleep–wake cyc
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35

Gábos, András, and István György Tóth. Recession, Recovery, and Regime Change: Effects on Child Poverty in Hungary. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198797968.003.0006.

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Despite high spending on family benefits and the high poverty reduction effectiveness of cash benefits, the risk of child poverty in Hungary have been higher than the EU average since the early 1990s in which the relatively high share of children in very low work-intensity households played a significant role. The crisis period brought an even higher poverty risk for children. According to the chapter’s findings, the increase in child poverty in the first phase of the crisis was driven by labour market processes (an increasing share of children in low work-intensity households), while the auto
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36

The economic effects of significant U.S. import restraints, phase III, services: With a computable general equilibrium analysis of significant U.S. import restraints : report to the Committee on Finance of the United States Senate, on investigation no. 332-262 under section 332 of the Tariff Act of 1930. U.S. International Trade Commission, 1991.

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37

Feng, Alexander J., George C. Chang Chien, and Alan D. Kaye. NMDA Receptor Antagonists, Gabapentinoids, Alpha-2 Agonists, and Dexamethasone. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190457006.003.0002.

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Surgical pain is a major obstacle in the recovery of patients. Effective pain management is of upmost importance to optimize a patient’s recovery, decrease medical complications, and increase patient satisfaction. Traditional pain management with opioids and nonsteroidal anti-inflammatory drugs have significant side effect profiles leading to medical complications or insufficient pain management from reluctance of use. Adjuvant analgesic can provide improved pain management with significantly less side effect profile. In addition, the clinician can, with synergistic effects of adjuvant medicat
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38

Rakel, Birgit. Integrative Treatment of Anxiety. Edited by Anthony J. Bazzan and Daniel A. Monti. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190690557.003.0019.

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Anxiety and anxiety disorders are among the most common complaints of people in all populations. Fear and anxiety are similar, but fear relates to immediate threats while anxiety refers to anticipation of future threats. Patients with anxiety symptoms frequently seek integrative approaches to help reduce their symptoms. Medications such as benzodiazepines are useful in certain anxiety conditions but have a number of side effects and may be addictive. Dietary influences can have a significant effect of augmenting or alleviating anxiety. Gut microbiota may play an important role in anxiety and o
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39

Bread: Consumption, Cultural Significance and Health Effects. Nova Science Publishers, Incorporated, 2017.

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40

The Economic effects of significant U.S. import restraints: Report to the Committee on Finance of the United States Senate on investigation no. 332-262 under section 332 of the Tariff Act of 1930. U.S. International Trade Commission, 1989.

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41

Nutt, David J., and Liam J. Nestor. Pharmacodynamics of addictive substances. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198797746.003.0006.

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Pharmacodynamics refers to the effects addictive substances have on the body. Acutely, substances of addiction target various neurotransmitter systems in the brain. The pharmacological actions of these substances at receptors results in their physiological and psychological effects. The chronic abuse of these substances, however, leads to pharmacodynamic tolerance at receptors within neurotransmitter systems and leads to addiction. This tolerance means that a greater amount of the substance is required to achieve the desired effect and it has significant implications for relapse during early a
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42

Crits-Christoph, Paul, and Jacques P. Barber. Psychological Treatments for Personality Disorders. Oxford University Press, 2015. http://dx.doi.org/10.1093/med:psych/9780199342211.003.0027.

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For the treatment of borderline personality disorder, a meta-analysis found statistically significant effects indicating a beneficial effect of dialectical behavior therapy (DBT) over treatment as usual for reduction in anger, parasuicidality, and mental health. All of these effects were moderate to large. However, DBT is not uniquely effective for borderline personality disorder. Two type 1 randomized controlled trials found equal effects for versions of psychodynamic therapy. Single type 1 studies have also supported the efficacy, compared to treatment as usual, of cognitive therapy, schema
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43

Fidler, Fiona. From Statistical Significance to Effect Estimation. Taylor & Francis Group, 2022.

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44

Fidler, Fiona. From Statistical Significance to Effect Estimation. Taylor & Francis Group, 2022.

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45

Aviation and the environment: Aviation's effects on the global atmosphere are potentially significant and expected to grow : report to the Honorable James L. Oberstar, Ranking Democratic Member, Committee on Transportation and Infrastructure, House of Representatives. The Office, 2000.

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46

Cavanna, Andrea E. Topiramate. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198791577.003.0013.

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Topiramate is a second-generation antiepileptic drug characterized by a good range of antiepileptic indications, with an acceptable interaction profile in polytherapy. Topiramate has an acceptable behavioural tolerability profile, although it has been associated with a number of negative behavioural effects in patients with epilepsy (in particular depression, irritability, and psychotic symptoms). Identified risk factors for the development of behavioural adverse effects include high starting doses and rapid titration schedules, as well as personal or family history of psychiatric disorders. T
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47

Forgiveness: Social Significance, Health Impact and Psychological Effects. Nova Science Publishers, Incorporated, 2015.

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48

Beattie, R. Mark, Anil Dhawan, and John W.L. Puntis. Nutritional management of Crohn's disease. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198569862.003.0043.

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Nutritional status 304Treatment 304Refeeding syndrome 306Monitoring 306Food reintroduction 307Continued nutritional support following exclusive enteral nutrition 307Crohn's disease in childhood has a significant effect on growth and development.Enteral nutrition as a treatment for Crohn's disease was first introduced in the 1970s and is used as a primary therapy in children because of its proven efficacy, lack of side effects and positive impact on growth. The aim is to induce remission while promoting weight gain and subsequent height gain and pubertal development....
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49

Lochman, John E., Caroline Boxmeyer, Nicole Powell, and Thomas J. Dishion. Child-Focused Cognitive-Behavioral Interventions Designed to Reduce Aggression. Edited by Thomas J. Dishion and James Snyder. Oxford University Press, 2015. http://dx.doi.org/10.1093/oxfordhb/9780199324552.013.30.

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This chapter describes issues related to cognitive-behavioral group-based interventions for children with aggressive behavior problems. It describes beneficial aspects of group formats and notes the longer-term effects of the Coping Power program. It discusses potential problems in group-based interventions with aggressive children, including the potential for deviant peer effects and deviancy training. It then describes a study of Coping Power that randomly assigned schools to either group or individual formats for aggressive children. Results indicated significant reduction in behavioral pro
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50

Compassion: Social Significance, Role in Healthcare and Psychological Effects. Nova Science Publishers, Incorporated, 2015.

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