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Dissertations / Theses on the topic 'Significant molecules'

Author: Grafiati

Published: 18 May 2024

Last updated: 31 July 2025

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1

Peppe, Salvatore. "Some unusual, astronomically significant organic molecules." Title page, contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09php4241.pdf.

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Appendix inside back cover. "June 2002" Bibliography: leaves 157-168. Experimental and theoretical studies were carried out on a number of unusual organic molecules of potential astronomical significance. The experimental work was corroborated by various theoretical approaches and by utilising computer-based quantum chemical calculations. Various covalently bound, anionic and neutral oxocarbon species were formed and studied. Additionally, two analogous heterocumulenic systems were investigated. Some isomers of either system, when energised, were shown to undergo gas-phase rearrangement proces

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2

Morisawa, Yusuke. "Spectroscopic study of some chemically significant molecules in molecular clouds." 京都大学 (Kyoto University), 2005. http://hdl.handle.net/2433/144599.

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3

Ray, Samapika. "Study to explore inclusion complexations and assorted interactions of some industrially and biologically significant molecules in diverse systems." Thesis, University of North Bengal, 2022. http://ir.nbu.ac.in/handle/123456789/4789.

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4

Barman, Siti. "Investigation on solvation behaviour and host guest inclusion complexes of some significant molecules with diverse cyclic compounds." Thesis, University of North Bengal, 2017. http://ir.nbu.ac.in/handle/123456789/2588.

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5

Dutta, Ashutosh. "Exploration of diversified interactions of some significant compounds prevalent in several environments by physicochemical contrivance." Thesis, University of North Bengal, 2018. http://ir.nbu.ac.in/handle/123456789/2787.

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6

Day, G. M., T. G. Cooper, A. Cruz-Cabeza, et al. "Significant progress in predicting the crystal structures of small organic molecules ¿ a report on the fourth blind test." International Union of Crystallography, 2009. http://hdl.handle.net/10454/4748.

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no<br>We report on the organization and outcome of the fourth blind test of crystal structure prediction, an international collaborative project organized to evaluate the present state in computational methods of predicting the crystal structures of small organic molecules. There were 14 research groups which took part, using a variety of methods to generate and rank the most likely crystal structures for four target systems: three single-component crystal structures and a 1:1 cocrystal. Participants were challenged to predict the crystal structures of the four systems, given only their molecu

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7

Campanher, Carlos Henrique. "A aprendizagem significativa crítica aplicada ao ensino da constante de Avogadro e o Mol." Universidade Federal do Pampa, 2016. http://dspace.unipampa.edu.br:8080/xmlui/handle/riu/1038.

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8

Muneer, Saiqa. "Novel nanoformulations and nanosensors for bioactive molecules of biomedical significance." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/213224/1/Saiqa_Muneer_Thesis.pdf.

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This thesis demonstrates novel nanosensors and nanomaterials for the sensitive detection of bioactive molecules (antibody therapeutics and antibiotics) in complex biological matrices utilizing thiol chemistry for label-free SERS detection. In addition to biomedical analysis, formulation development of dry powder inhalers overcomes the issues of adverse effects associated with parenteral or oral route of drug administration. It is expected to accomplish the key requisites like aerosolization properties, physicochemical characteristics, biocompatibility, and biodegradation with minimal side effe

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9

Tascilar, Metin. "Clinical significance of molecular markers in pancreatic cancer." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/61858.

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10

ZHANG, XIN. "Surface functionalization of bioactive glasses with natural molecules of biological significance." Doctoral thesis, Politecnico di Torino, 2014. http://hdl.handle.net/11583/2535899.

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Natural or artificial materials used for replacement or supplement the functions of living tissues, termed as biomaterials, may be bioinert (i.e. alumina and zorconia,) resorbable (i.e. tricalcium phosphate), bioactive (i.e. hydroxyapatite, bioactive glasses, and glass-ceramics) or porous for tissue ingrowth (i.e. hydroxyapatite-coated metals). Among all the biomaterials, bioactive glass and glass-ceramics are widely used in orthopedic and dental applications and are being developed for tissue engineering. However, to a large extent, the behavior and overall performance of biomaterials are gov

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11

Agarwalla, H. "Design and synthesis of molecular probes for biological and environmental significant ions." Thesis(Ph.D.), CSIR- National Chemical Laboratory, Pune, 2016. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2246.

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12

Lapthorn, Cristian Lewis. "The application of ion mobility mass spectrometry to molecules of pharmaceutical significance." Thesis, University of Greenwich, 2016. http://gala.gre.ac.uk/18125/.

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Ion mobility-mass spectrometry experiments have been conducted to measure the drift-time and calculate collision cross-sections (CCSs) using travelling wave ion mobility spectrometry, and determine the CCS using drift-tube ion mobility spectrometry systems of analytes. The aim of the study was to identify if predictive approaches could facilitate rapid and definitive assignment of charge location sites and chemical structure. Molecular modelling was conducted to determine the energy minimised/geometry optimised structures and charge distribution of the protonated molecules studied. The geometr

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13

Hardingham, Jennifer E. "Molecular detection and significance of circulating colorectal cancer cells /." Title page, table of contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phh264.pdf.

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14

Sarinas, Simon. "Application of Fourier Transform Raman Spectroscopy to the characterisation of significant biological materials." Thesis, Queensland University of Technology, 1994. https://eprints.qut.edu.au/37167/1/37167_Sarinas_1994.pdf.

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Raman spectroscopy has experienced a true "renaissance" since the development of Fourier Transform Raman instrumentation. The objective of this thesis is to illustrate the versatility of FT-Raman spectroscopy for the investigation and characterisation of biological molecules and systems. In addition to the positive attributes possessed by FT-Raman spectroscopy for such analysis, inherent shortcomings of the technique are discussed. This report serves as a concise reference for any researcher or analytical scientist considering FT-Raman spectroscopy for the analysis of biomolecular systems.

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15

Day, Richard Michael. "Study of the pathogenic significance of epithelial cell adhesion molecules in inflammatory bowel disease." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286598.

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16

Ali, Hamid Raza. "Molecular classification of breast cancer : histology-based assays and clinical significance." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607764.

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17

Anjomshoaa, Ahmad, and n/a. "Prognostic significance of a gene proliferation signature in colorectal cancer." University of Otago. Department of Biochemistry, 2007. http://adt.otago.ac.nz./public/adt-NZDU20071218.134516.

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Aberrant cell proliferation is a fundamental feature of cancer. It is thus not unexpected that many studies have been devoted to the exploration of tumour cell proliferation as a potential indicator of outcome. Indeed, in most malignancies, high expression of proliferation markers and more accurately, increased expression of proliferation-related genes have been strongly associated with poor outcome. In colorectal cancer (CRC), however, discordant results have been reported and the prognostic significance of cell proliferation has not been demonstrated in this type of cancer. As these results

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18

Silva, Carolina de Barros Machado da. "Filogenia molecular e filogeografia do gênero Salminus (Characiformes)." Universidade Federal de São Carlos, 2016. https://repositorio.ufscar.br/handle/ufscar/9371.

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19

Wong, Hetty Ngan-Ha 1969. "Characterization and significance of calnexin phosphorylation in mammals and Schizosaccharomyces pombe." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36851.

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Alteration in protein folding and its subsequent trafficking has been increasingly recognized as the molecular basis of numerous diseases. Cells have acquired a quality control mechanism to ensure proper folding and assembly of proteins. Misfolded and unassembled proteins are recognized by the quality control machinery at the ER and are retained and subsequently targeted for degradation. Calnexin has been identified as one of the major constituents of the ER quality control machinery. Calnexin is a type I phosphoprotein of the ER membrane. The luminal domain of calnexin displays a lectin-like

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20

Han, Wei 1964. "Molecular electrophysiology underlying repolarization in canine cardiac purkinje cells : characterization and significance." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82889.

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Cardiac Purkinje fibers (PFs) play a very important role in cardiac electrophysiology. They are crucial for assuring appropriate timing and sequence of ventricle contraction and play an important role in cardiac arrhythmogenesis, largely via abnormalities in repolarization. Little work has been done to define the molecular electrophysiology of cardiac Purkinje cells (PCs). The primary hypothesis of this thesis was that PCs have unique molecular determinants of repolarization. The specific objectives were to characterize the repolarizing currents in isolated canine PCs, to clarify the mo

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21

Cáceres, Aguilar Mario. "Inversiones Cromosómicas de Drosophila: Origen Molecular y Significado Evolutivo de su Tamaño." Doctoral thesis, Universitat Autònoma de Barcelona, 2000. http://hdl.handle.net/10803/3910.

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22

Takada, Yoshinori. "Molecular elucidation of the physiological significance of Ca2+ channelsome in neuronal function." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/202810.

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23

Maran, Louise Helena Martins Maran [UNESP]. "Filogenia molecular de Mazama americana (Artiodactyla: Cervidae) como auxílio na resolução das incertezas taxonômicas." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/140141.

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Lincoln, Sara Ann Lincoln Ph D. Massachusetts Institute of Technology. "Molecular studies of the sources and significance of archaeal lipids in the oceans." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/84916.

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Thesis (Ph. D. in Geochemistry)--Massachusetts Institute of Technology, Dept. of Earth, Atmospheric, and Planetary Sciences, 2013.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Marine archaea are ubiquitous and abundant in the modem oceans and have a geologic record extending >100 million years. However, factors influencing the populations of the major clades - chemolithoautotrophic Marine Group I Thaumarchaeota (MG-I) and heterotrophic Marine Group II Euryarchaeota (MG-II) - and their membrane lipid signatures are not well understood. Here, I paired techn

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25

Fiandalo, Michael Vincent. "PROTEASOME REGULATION OF CASPASE-8: SIGNIFICANCE IN CANCER." UKnowledge, 2012. http://uknowledge.uky.edu/biochem_etds/3.

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Anti-tumor therapeutic strategies based on combinations of chemotherapeutic agents with a death inducing ligand such as TNF-α Related Apoptosis Inducing Ligand (TRAIL), are directed towards selective and effective cancer cell apoptosis and enhanced therapeutic response. We previously demonstrated that proteasome inhibition sensitizes TRAIL resistant prostate cancer cells to TRAIL-mediated apoptosis via stabilization of the active p18 subunit of initiator caspase-8. The present study investigated the functional link between caspase-8 and the proteasome, by analyzing the impact of caspase-8 ubiq

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26

Du, Shuhua. "Identification of the Functional Significance of a Novel Genetic Modifier of p53 – Ovca1." Ohio University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1301528581.

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27

Jurutka, Peter Wesley. "Characterization and evaluation of the functional significance of phosphorylation of the vitamin D receptor." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186336.

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The hormonal actions of 1,25-dihydroxyvitamin D3 (1,25(OH)₂D₃) are mediated by a nuclear 1,25(OH)₂D₃ receptor phosphoprotein (VDR). The phosphorylation of VDR was characterized in rat osteoblast-like cells (ROS 1712.S). In these bone cells, rat VDR (rVDR) was phosphorylated in the absence of the 1,25(OH)₂D₃ ligand and became hyperphosphorylated upon binding the sterol hormone or a novel, noncalcemic analog, 22-oxa-calcitriol. Treatment of ROS 17/2.S cells, transfected with a 1,25(OH)₂D₃-responsive reporter vector, with increasing concentrations of 1 ,25(OH)₂D₃ indicated a positive correlation

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28

Yamada, Ayako. "Dynamic self-organization of biomolecules in relation to their biological significance : single giant DNA and phospholipid molecules." 京都大学 (Kyoto University), 2008. http://hdl.handle.net/2433/136864.

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29

Kelley, Joanna L. "Adaptive evolution : from genome-wide scans to biological significance /." Thesis, Connect to this title online; UW restricted, 2008. http://hdl.handle.net/1773/10256.

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30

Robinson, Jason M. "Functional Significance of mtDNA Cytosine Modification Tested by Genome Editing." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4561.

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The field of epigenetics is gaining popularity and speed, due in part to its capability to answer lingering questions about the root cause of certain diseases. Epigenetics plays a crucial role in regulation of the cell and cell survival, particularly by cytosine methylation. It remains controversial if DNMT’s which facilitate methylation are present in mammalian mitochondria and what the functional significance they may have on modification of mitochondrial DNA. CRISPR-Cas9 technology enabled genome editing to remove the MTS (mitochondrial targeting sequence) from DNMT1 of HCT116 cells, purpos

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31

Lin, Zhou. "Theoretical Studies on the Spectroscopy and Dynamics of Astrochemically Significant Species." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429633299.

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32

Venn, Alexander Ashley. "Coral bleaching : the significance of the molecular diversity and photoprotective pigments of zooxanthellae (Symbiodinium)." Thesis, University of York, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423605.

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33

Ho-Yen, Colan Maxwell. "The significance of c-Met in different molecular sub-types of invasive breast cancer." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8907.

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Introduction: Basal-like (BL) breast cancer is an aggressive sub-type of breast cancer for which there is no targeted systemic therapy. C-Met is a receptor tyrosine kinase implicated in breast cancer. Clinical trials assessing the efficacy of anti-c-Met therapy are underway, yet few studies have analysed the clinical significance of c-Met expression and/or activation in breast cancer, in particular whether there is a correlation with molecular sub-type. The aims of this study are: 1) to establish the clinical significance of c-Met expression in invasive breast cancer, 2) evaluate the novel pro

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34

Lafleur, Christine. "The significance of enzyme 3-ß-hydroxysterol - delta24 reductase in cholesterol biosynthesis and steroidogenesis: an «in vitro» model to study Desmosterolosis." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=67031.

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Desmosterolosis is an autosomal recessive condition in which affected individuals lack expression of the final enzyme in the cholesterol biosynthetic pathway, 3β-hydroxyΔ²4cholesterol reductase (DHCR24). The enzyme is responsible for converting desmosterol to cholesterol. It is characterized by several congenital abnormalities, as well as high circulating levels of desmosterol accompanied by hypocholesterolemia. This study was intended to examine the molecular disruptions involved in desmosterolosis and determine the potential impact on steroidogenesis using an in vitro appro

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35

Manojlovic, Zarko, Austin Christofferson, Winnie S. Liang, et al. "Comprehensive molecular profiling of 718 Multiple Myelomas reveals significant differences in mutation frequencies between African and European descent cases." PUBLIC LIBRARY SCIENCE, 2017. http://hdl.handle.net/10150/626468.

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Multiple Myeloma (MM) is a plasma cell malignancy with significantly greater incidence and mortality rates among African Americans (AA) compared to Caucasians (CA). The overall goal of this study is to elucidate differences in molecular alterations in MM as a function of self-reported race and genetic ancestry. Our study utilized somatic whole exome, RNA-sequencing, and correlated clinical data from 718 MM patients from the Multiple Myeloma Research Foundation CoMMpass study Interim Analysis 9. Somatic mutational analyses based upon self-reported race corrected for ancestry revealed significan

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36

Zhang, Xiaomeng. "Significance and molecular basis of Id-1 in regulation of cancer cell survival and invasion." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39325477.

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37

Zhang, Xiaomeng, and 張效萌. "Significance and molecular basis of Id-1 in regulation of cancer cell survival and invasion." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39325477.

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38

Liesenberg, Franziska [Verfasser]. "Aberrant expression of microRNA in gliomas: Molecular mechanisms, functional consequences and clinical significance / Franziska Liesenberg." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2012. http://d-nb.info/102394698X/34.

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39

Sideris, Michail. "The significance of molecular biomarkers in the recurrence of rectal tumors after Transanal Endoscopic Microsurgery." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/the-significance-of-molecular-biomarkers-in-the-recurrence-of-rectal-tumors-after-transanal-endoscopic-microsurgery(e16b37d2-b2d4-47fb-9c30-563cd06be58d).html.

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Local excision (LE) of rectal cancer has been practiced as a treatment for 30 years on a highly selected group of patients and tumours. A method of local excision which has recently gained wider acceptance in the treatment of low-grade CRC (T1) is transanal endoscopic microsurgery (TEMS). TEMS offers advantages for operative access and oncological clearance compared to those of transanal resection (TAR). A number of studies have shown that TEMS can have almost equal results to radical surgery for early rectal cancer. Radical surgery has the disadvantage of an approximate mortality rate of 5% a

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40

Yamamoto, Shinichiro. "Reactive Oxygen Species / Reactive Nitrogen Species-sensitive TRP channels : Molecular Activation Mechanism and Physiological Significance." 京都大学 (Kyoto University), 2008. http://hdl.handle.net/2433/124503.

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41

Alajtal, Adel I. "Raman spectroscopic application for the analysis of organic compounds and minerals of astrobiological significance. The detection and discrimination of organic compounds and mineral analogues in pure and mixed samples of astrobiological significance using raman spectroscopy, XRD and scanning electron microscopy." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/4425.

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Raman spectroscopy has been used to characterise both organic and geological samples in order to build a database for the future characterization of biomarker molecules that are of astrobiological relevance. Characteristic geological features and hydrated minerals recently found on the surface of Mars by the NASA planetary rovers Spirit and Opportunity suggest that a possible biosphere could have once existed there. Analytical instrumentation protocols for the unequivocal detection of biomarkers in suitable geological matrices are critical for future unmanned explorations, including the forthc

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42

Landry, Sebastien. "Gamma-glutamyl carboxylase gene expression in cultured marrow stromal cells : significance for cell therapy of hemophilia B." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80310.

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Gamma-glutamyl carboxylase (GGCX) is an enzyme essential for the post-translational modification of glutamic acid residues found within the gamma-carboxyglutamic acid (GLA) domain of vitamin K-dependent blood coagulation factors as well as other proteins principally involved in bone development such as Osteocalcin and Matrix Gla Protein. We propose that Marrow Stromal Cells (MSC) may serve as a useful Factor IX (FIX) delivery vehicle in vivo. As part of the validation of this cellular delivery platform for gene therapy, we determined whether MSCs endogenously express the GGCX gene. We d

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Alajtal, Adel Imhemed. "Raman spectroscopic application for the analysis of organic compounds and minerals of astrobiological significance : the detection and discrimination of organic compounds and mineral analogues in pure and mixed samples of astrobiological significance using raman spectroscopy, XRD and scanning electron microscopy." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/4425.

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Raman spectroscopy has been used to characterise both organic and geological samples in order to build a database for the future characterization of biomarker molecules that are of astrobiological relevance. Characteristic geological features and hydrated minerals recently found on the surface of Mars by the NASA planetary rovers Spirit and Opportunity suggest that a possible biosphere could have once existed there. Analytical instrumentation protocols for the unequivocal detection of biomarkers in suitable geological matrices are critical for future unmanned explorations, including the forthc

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44

Mahmoud, Tamer I. "The significance of heavy chain CDR3 diversity in the antibody response to polysaccharides." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009p/mahmoud.pdf.

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45

Malaney, Prerna. "Significance of PTEN Phosphorylation and its Nuclear Function in Lung Cancer." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6539.

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Phosphorylation mediated inactivation of PTEN leads to multiple malignancies with increased severity. However, the consequence of such inactivation on downstream functions of PTEN are poorly understood. Therefore, the objective of my thesis is to ascertain the molecular mechanisms by which PTEN phosphorylation drives lung cancer. PTEN phosphorylation at the C-terminal serine/threonine cluster abrogates its tumor suppressor function. Despite the critical role of the PTEN C-tail in regulating its function, the crystal structure of the C-tail remains unknown. Using bioinformatics and structural a

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46

Pan, Qing, and 潘庆. "Functions and physiological significance of the N- and C- terminal regions of the Escherichia coli global transcription factor FNR." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196081.

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A facultative anaerobe such as Escherichia coli is able to switch between the aerobic and anaerobic modes of metabolism in response to O2 availability. This adaptation is primarily controlled by a global transcription regulator called FNR (fumarate nitrate reduction). The key property that allows FNR to act as an O2 responsive transcription factor is its capability to dimerize and being activated upon binding of an O2 labile [4Fe-4S]2+ cluster. Previous functional studies have largely focused on the regions of FNR analogous to CRP (cAMP receptor protein), a prototype CRP/FNR family protein whi

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47

Sun, Kin-wai, and 孫建維. "The significance of proline rich tyrosine kinase 2 (PYK2) in proliferation and invasiveness of hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40687375.

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48

Radinsky, Robert. "The significance of the viral-Kirsten-ras oncogene during tumor progression in a BALB/c 3T3 model system." Case Western Reserve University School of Graduate Studies / OhioLINK, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=case1058984282.

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49

Manivannan, Sathiya Narayanan. "TRANSCRIPTIONAL CONTROL OF AN ESSENTIAL RIBOZYME AND AN EGFR LIGAND REVEAL SIGNIFICANT EVENTS IN INSECT EVOLUTION." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1437053490.

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50

Dauksaite, Vita. "The Modular Domain Structure of ASF/SF2: Significance for its Function as a Regulator of RNA Splicing." Doctoral thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3579.

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<p>ASF/SF2 is an essential splicing factor, required for constitutive splicing, and functioning as a regulator of alternative splicing. ASF/SF2 is modular in structure and contains two amino-terminal RNA binding domains (RBD1 and RBD2), and a carboxy-terminal RS domain. The results from my studies show that the different activities of ASF/SF2 as a regulator of alternative 5’ and 3’ splice site selection can be attributed to distinct domains of ASF/SF2.</p><p>I show that ASF/SF2-RBD2 is both necessary and sufficient to reproduce the splicing repressor function of ASF/SF2. A SWQDLKD motif was sh

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