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Journal articles on the topic 'Signifying induction'

Author: Grafiati

Published: 6 October 2023

Last updated: 31 July 2025

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1

Van Der Walt, J. H., and J. A. Carter. "The Effect of Different Pre-Operative Feeding Regimens on Plasma Glucose and Gastric Volume and pH in Infancy." Anaesthesia and Intensive Care 14, no. 4 (1986): 352–59. http://dx.doi.org/10.1177/0310057x8601400405.

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The effects of four different pre-operative feeding regimens were studied in 123 children below the age of one year presenting for surgery. Plasma glucose concentrations, blood acid-base values, gastric volume and gastric pH were measured before and after induction of anaesthesia. No patient was found to be hypoglycaemic and there were no significant differences in plasma glucose concentration and acid-base values between the groups. No correlation was demonstrated between the age and weight of the patients and the duration of fasting and the plasma glucose concentration. There was a significa

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2

Dickmann, Iddo. "The Double-Mirror Gaze, Transcoded Testimony, and Disqualified Witnesses in the Talmud." Journal of Jewish Thought and Philosophy 31, no. 2 (2023): 127–62. http://dx.doi.org/10.1163/1477285x-12341348.

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Abstract I will argue that the underlying rationale for the talmudic list of trades disqualified from legal testimony is aesthetic. These trades involved professional mimicry, which as such incapacitated what R. Neis has termed “homovisuality” or self-referential witnessing in the Talmud. Reading talmudic laws of conjoined testimony and the induction of witnesses in light of Deleuze’s and Blanchot’s philosophy, I will argue that homovisuality entailed the witness’s reincarnation as the subject of the event, thus re-signifying rather than reporting the event. The judge, transformed into a witne

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3

Thind, Nancy, Pranav Sood, Rajeev Sood, and Geetika Gupta Syal. "Comparison of the efficacy, safety, acceptability and fetomaternal outcomes of combination of mifepristone and foley’s catheter with foley’s catheter alone in induction of labour in term pregnancies with previous lower segment caesarean section." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 10 (2020): 4181. http://dx.doi.org/10.18203/2320-1770.ijrcog20204310.

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Background: Objective of the study was to compare the efficacy, safety, acceptability, fetomaternal outcomes of combination of mifepristone and Foley’s catheter with Foley’s catheter alone in induction of labor in term pregnancies with previous Lower segment caesarean section (LSCS).Methods: This was a prospective study of 36 women induced with mifepristone and foley’s catheter and 36 women induced with foley’s catheter alone at 37 weeks to 41+6 weeks with previous LSCS.Results: Mean bishop score on admission in combined group (2.44) was comparable with that of foley’s alone group (2.91, p=0.8

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Güneş, Eda. "Alteration in the oxidative status of Drosophila melanogaster Meigen (Diptera: Drosophilidae) fed with a diet containing Centaurea depressa M. Bieb. (Asteraceae)." Animal Biology 70, no. 2 (2020): 227–37. http://dx.doi.org/10.1163/15707563-20191153.

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Abstract The aim of the this study was to evaluate the effects of fresh, dried and freeze-dried Centaurea depressa M. Bieb. (Asteraceae) on the oxidant and antioxidant status of the model organism D. melanogaster Meigen (Diptera: Drosophilidae) experimentally. The study was carried out from 2016 to 2019, and plant leaf extracts (0-50 mg/l) were added to insect standard artificial diets. The total protein, protein carbonyl content and glutathione-S-transferase, superoxide dismutase and catalase activities were quantified at the insect’s third larval stage. Our data showed that protein carbonyl

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Park, Jiyeon, Gyeong Tae Eom, Joon Young Oh, et al. "High-Level Production of Bacteriotoxic Phospholipase A1 in Bacterial Host Pseudomonas fluorescens via ABC Transporter-Mediated Secretion and Inducible Expression." Microorganisms 8, no. 2 (2020): 239. http://dx.doi.org/10.3390/microorganisms8020239.

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Bacterial phospholipase A1 (PLA1) is used in various industrial fields because it can catalyze the hydrolysis, esterification, and transesterification of phospholipids to their functional derivatives. It also has a role in the degumming process of crude plant oils. However, bacterial expression of the foreign PLA1-encoding gene was generally hampered because intracellularly expressed PLA1 is inherently toxic and damages the phospholipid membrane. In this study, we report that secretion-based production of recombinant PlaA, a bacterial PLA1 gene, or co-expression of PlaS, an accessory gene, min

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Sumedha Dhar, Debasish Ghosh, Soma Chakraborty, Sandesh Rathod, Navneet Kumar, and Debasish Saha. "Ultrasound-guided assessment of gastric volume in fasting diabetic and non-diabetic patients undergoing elective surgery." Asian Journal of Medical Sciences 16, no. 5 (2025): 125–30. https://doi.org/10.71152/ajms.v16i5.4161.

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Background: Autonomic gastropathy despite standard fasting in diabetic patients increases the risk of aspiration. Aims and Objectives: This study compared ultrasound-guided measurement of residual gastric volume (GV) between diabetic and non-diabetic patients scheduled for elective surgery. Materials and Methods: The study was a prospective observational study carried out on 42 patients with similar demographic characteristics, having similar fasting intervals >8 hours. Qualitative and quantitative ultrasonographic assessment of gastric antrum in supine and right lateral decubitus (RLD) was

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Shalmani, Abdullah, Izhar Muhammad, Rahat Sharif, et al. "Zinc Finger-Homeodomain Genes: Evolution, Functional Differentiation, and Expression Profiling Under Flowering-Related Treatments and Abiotic Stresses in Plants." Evolutionary Bioinformatics 15 (January 2019): 117693431986793. http://dx.doi.org/10.1177/1176934319867930.

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Zinc finger-homeodomain (ZHD) proteins constitute a plant-specific transcription factor family that play important roles in plant growth, development, and stress responses. In this study, we investigated a total of 10, 17, and 31 ZHD gene members in the peach, Arabidopsis, and apple genome, respectively. The phylogenetic tree divided the identified ZHD genes into 4 subfamilies based on their domain organization, gene structure, and motif distribution with minor variations. The ZHD gene family members were unevenly distributed throughout in apple, peach, and Arabidopsis genomes. Segmental dupli

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Sporn, S. A., D. F. Eierman, C. E. Johnson, et al. "Monocyte adherence results in selective induction of novel genes sharing homology with mediators of inflammation and tissue repair." Journal of Immunology 144, no. 11 (1990): 4434–41. http://dx.doi.org/10.4049/jimmunol.144.11.4434.

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Abstract Adherence of monocytes to endothelial cells or extracellular matrices is likely to play a critical role in triggering monocyte activation in extravascular sites of infection, chronic inflammatory disorders, tissue damage and neoplastic growth. We have constructed a cDNA library from monocytes adhered for 30 min on plastic and have screened it by differential hybridization for mRNA rapidly induced by adherence. Two of the cDNA isolated have been identified as IL-1 beta and superoxide dismutase. Sequence data from three other adherence specific clones demonstrates the presence of ATTTA

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Hart, Abarasi, Mohamed Adam, John P. Robinson, Sean P. Rigby, and Joseph Wood. "Tetralin and Decalin H-Donor Effect on Catalytic Upgrading of Heavy Oil Inductively Heated with Steel Balls." Catalysts 10, no. 4 (2020): 393. http://dx.doi.org/10.3390/catal10040393.

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The Toe-to-Heel Air Injection (THAI) combined with catalytic upgrading process in situ (CAPRI) has demonstrated it can simultaneously extract and upgrade heavy oil in situ. This paper reports the investigation of augmenting temperature deficit and suppressing coke formation in the CAPRI section through the incorporation of induction heating and H-donor solvents. An induction-heated catalytic reactor was designed and developed, heated with steel balls in a mixed bed of NiMo/Al2O3 catalyst (66% v/v) to 425 °C temperature, 15 bar pressure and 0.75 h−1 LHSV (Liquid Hourly Space Velocity). The cata

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Bell, Erica, Amy Webb, Joseph Stanek, et al. "BIOM-49. A PILOT STUDY OF CEREBROSPINAL FLUID EXOSOMAL SMALL RNA-SEQUENCING IN PEDIATRIC MEDULLOBLASTOMA PATIENTS ON THE NEXT CONSORTIUM “HEAD START” 4 PROTOCOL." Neuro-Oncology 24, Supplement_7 (2022): vii15—vii16. http://dx.doi.org/10.1093/neuonc/noac209.059.

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Abstract BACKGROUND Head Start 4 is a randomized clinical trial to determine whether dose-intensive tandem consolidation, compared with a single cycle, with autologous hematopoietic progenitor cell rescue provides a survival benefit in pediatric patients with medulloblastoma or other embryonal tumors. The trial incorporates upfront molecular subgrouping and non-mandatory, prospective blood and cerebrospinal fluid (CSF) collection. This pilot study aimed to identify exosomal non-coding RNAs (exo-ncRNAs) that might serve as novel diagnostic and/or treatment response biomarkers. METHODS CSF(1-2mL

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Robb, Lindsey, and Sheena Moffat. "Transition to Postgraduate Study at Master’s Level Lessons Learned:." Journal of Perspectives in Applied Academic Practice 8, no. 1 (2020): 41–51. http://dx.doi.org/10.14297/jpaap.v8i1.402.

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Evidence from UK universities’ Postgraduate Taught Experience Survey (PTES) concluded that whilst confident and experienced in their area of practice, some find the prospect of returning to study in an on-line environment and making the transition to Master’s Level daunting. In recognition of this, a small group created an online resource ‘Preparation for study at Master’s Level’ which students have access to as part of the induction process for the taught postgraduate programme, MSc in Advanced Practice in the School of Health and Social Care at Edinburgh Napier University.  This paper

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Al-Bayati, Ammar I., Ammar A. Razzak Mahmood, Zainab A. Al-Mazaydeh, et al. "Synthesis, docking study, and in vitro anticancer evaluation of new flufenamic acid derivatives." Pharmacia 68, no. 2 (2021): 449–61. http://dx.doi.org/10.3897/pharmacia.68.e66788.

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Novel compounds (6–10) were synthesized and confirmed by spectroscopic analysis, including AT-IR, 1HNMR and CHNS. Their cytotoxic effect was evaluated by MTT assay against two cancer cell lines and two normal cell types. Compound 7 exhibited anticancer activity against MCF-7 breast cancer cell line (GI50 = 63.9 µg/ml, 148 µM), without any effect against A549 lung cancer cells, or the normal cells. Compound 7 caused cytotoxicity in MCF-7 breast cancer cells by apoptotic cell death, as suggested by fragmented nuclei after DAPI staining and agarose gel electrophoresis. In addition, treating MCF-7

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Kelly, Ronan Joseph, Kellie Nicole Smith, Valsamo Anagnostou, et al. "Neoadjuvant nivolumab plus concurrent chemoradiation in stage II/III esophageal/gastroesophageal junction cancer." Journal of Clinical Oncology 37, no. 4_suppl (2019): 142. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.142.

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142 Background: Neoadjuvant chemoradiation (cRT) prior to surgical resection in stage II/III esophageal/gastroesophageal junction (E/GEJ) cancer results in a complete pathologic response rate (pCR) of 20-30%. The appearance of favorable microenvironment features (enhanced tumor infiltrating lymphocytes, perivascular lymphocytes and tertiary lymphoid structures) after induction therapy in resected EC suggest early stage tumors may respond favorably to immune based therapy and in particular to PD-1 blockade when combined with cRT. Methods: In this pilot study, we administered 2 cycles of inducti

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Türkoğlu, Aras, Kamil Haliloğlu, Fatih Demirel, et al. "Machine Learning Analysis of the Impact of Silver Nitrate and Silver Nanoparticles on Wheat (Triticum aestivum L.): Callus Induction, Plant Regeneration, and DNA Methylation." Plants 12, no. 24 (2023): 4151. http://dx.doi.org/10.3390/plants12244151.

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The objective of this study was to comprehend the efficiency of wheat regeneration, callus induction, and DNA methylation through the application of mathematical frameworks and artificial intelligence (AI)-based models. This research aimed to explore the impact of treatments with AgNO3 and Ag-NPs on various parameters. The study specifically concentrated on analyzing RAPD profiles and modeling regeneration parameters. The treatments and molecular findings served as input variables in the modeling process. It included the use of AgNO3 and Ag-NPs at different concentrations (0, 2, 4, 6, and 8 mg

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Al-Bayati, Ammar I., Mahmood Ammar A. Razzak, Zainab A. Al-Mazaydeh, et al. "Synthesis, docking study, and in vitro anticancer evaluation of new flufenamic acid derivatives." Pharmacia 68, no. (2) (2021): 449–61. https://doi.org/10.3897/pharmacia.68.e66788.

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Novel compounds (6–10) were synthesized and confirmed by spectroscopic analysis, including AT-IR, <sup>1</sup>HNMR and CHNS. Their cytotoxic effect was evaluated by MTT assay against two cancer cell lines and two normal cell types. Compound 7 exhibited anticancer activity against MCF-7 breast cancer cell line (GI<sub>50</sub> = 63.9 µg/ml, 148 µM), without any effect against A549 lung cancer cells, or the normal cells. Compound 7 caused cytotoxicity in MCF-7 breast cancer cells by apoptotic cell death, as suggested by fragmented nuclei after DAPI staining and agarose gel electrophoresis. In ad

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Medzikovic, Lejla, Hylja Heese, Pieter B. van Loenen, et al. "Nuclear Receptor Nur77 Controls Cardiac Fibrosis through Distinct Actions on Fibroblasts and Cardiomyocytes." International Journal of Molecular Sciences 22, no. 4 (2021): 1600. http://dx.doi.org/10.3390/ijms22041600.

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Fibrosis is a hallmark of adverse cardiac remodeling, which promotes heart failure, but it is also an essential repair mechanism to prevent cardiac rupture, signifying the importance of appropriate regulation of this process. In the remodeling heart, cardiac fibroblasts (CFs) differentiate into myofibroblasts (MyoFB), which are the key mediators of the fibrotic response. Additionally, cardiomyocytes are involved by providing pro-fibrotic cues. Nuclear receptor Nur77 is known to reduce cardiac hypertrophy and associated fibrosis; however, the exact function of Nur77 in the fibrotic response is

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Abou Najem, Sonia, Ghada Khawaja, Mohammad Hassan Hodroj, Patil Babikian, and Sandra Rizk. "Adjuvant Epigenetic Therapy of Decitabine and Suberoylanilide Hydroxamic Acid Exerts Anti-Neoplastic Effects in Acute Myeloid Leukemia Cells." Cells 8, no. 12 (2019): 1480. http://dx.doi.org/10.3390/cells8121480.

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Atypical epigenetic processes including histone acetylation and DNA methylation have been identified as a fundamental theme in hematologic malignancies. Such mechanisms modify gene expression and prompt, in part at least, the initiation and progression of several malignancies including acute myeloid leukemia. In the current study we determined the effects of treating KG-1 and U937 acute myeloid leukemia (AML) cells, in vitro, with the HDAC inhibitor, suberoylanilide hydroxamic acid (SAHA), or with a DNMT inhibitor, decitabine (DAC), or their combination, on cell proliferation, cell cycle progr

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van Niekerk, Gustav, Ashwin W. Isaacs, Theo Nell, and Anna-Mart Engelbrecht. "Sickness-Associated Anorexia: Mother Nature’s Idea of Immunonutrition?" Mediators of Inflammation 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/8071539.

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During an infection, expansion of immune cells, assembly of antibodies, and the induction of a febrile response collectively place continual metabolic strain on the host. These considerations also provide a rationale for nutritional support in critically ill patients. Yet, results from clinical and preclinical studies indicate that aggressive nutritional support does not always benefit patients and may occasionally be detrimental. Moreover, both vertebrates and invertebrates exhibit a decrease in appetite during an infection, indicating that such sickness-associated anorexia (SAA) is evolution

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Jubaidi, Fatin Farhana, Nur Liyana Mohammed Yusof, Satirah Zainalabidin, Izatus Shima Taib, Zariyantey Abd Hamid, and Siti Balkis Budin. "Determining the Time Points for the Development of Early and Advanced Stages of Diabetic Cardiomyopathy in Streptozotocin-Induced Type 1 Diabetes Mellitus Rat Model." Sains Malaysiana 53, no. 6 (2024): 1321–32. http://dx.doi.org/10.17576/jsm-2024-5306-08.

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The characteristics of early and advanced stages of diabetic cardiomyopathy (DCM) are well-understood; however, the time points by which these stages are developed in animal models vary and depend on the hyperglycaemic status and duration of diabetes. This study was aimed to determine the time points for the development of early and advanced stages of DCM from the induction of type 1 diabetes mellitus by identifying the functional and histological changes that occurred. Type 1 diabetes was induced via streptozotocin injection, and rats were divided into 4-week and 8-week diabetic groups. A gro

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Lesur, Isabelle, and Judith L. Campbell. "The Transcriptome of Prematurely Aging Yeast Cells Is Similar to That of Telomerase-deficient Cells." Molecular Biology of the Cell 15, no. 3 (2004): 1297–312. http://dx.doi.org/10.1091/mbc.e03-10-0742.

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To help define the pathologies associated with yeast cells as they age, we analyzed the transcriptome of young and old cells isolated by elutriation, which allows isolation of biochemical quantities of old cells much further advanced in their life span than old cells prepared by the biotin-streptavidin method. Both 18-generation-old wild-type yeast and 8-generation-old cells from a prematurely aging mutant (dna2-1), with a defect in DNA replication, were evaluated. Genes involved in gluconeogenesis, the glyoxylate cycle, lipid metabolism, and glycogen production are induced in old cells, signi

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Arjunan, Pachiappan, Radhika Swaminathan, Jessie Yuan, et al. "Exacerbation of AMD Phenotype in Lasered CNV Murine Model by Dysbiotic Oral Pathogens." Antioxidants 10, no. 2 (2021): 309. http://dx.doi.org/10.3390/antiox10020309.

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Emerging evidence underscores an association between age-related macular degeneration (AMD) and periodontal disease (PD), yet the biological basis of this linkage and the specific role of oral dysbiosis caused by PD in AMD pathophysiology remains unclear. Furthermore, a simple reproducible model that emulates characteristics of both AMD and PD has been lacking. Hence, we established a novel AMD+PD murine model to decipher the potential role of oral infection (ligature-enhanced) with the keystone periodontal pathogen Porphyromonas gingivalis, in the progression of neovasculogenesis in a laser-i

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Perez, Giselle K., Fangxin Hong, Andrew M. Evens, et al. "Patient-Reported Outcomes Among Patients with High-Risk Untreated Follicular Lymphoma (FL) Randomized to Bendamustine/Rituximab (BR) or Bendamustine/Rituximab with Bortezomib (BVR) Therapy: Results from the ECOG-ACRIN E2408 Study." Blood 136, Supplement 1 (2020): 45–46. http://dx.doi.org/10.1182/blood-2020-140502.

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Introduction: FL is the most common indolent non-Hodgkin lymphoma in the Western world. FL may cause disease-related symptoms, and patients with high-risk disease usually require systemic therapy. BR is commonly used as first-line therapy for high-risk FL, and the addition of bortezomib to a BR backbone has been studied (Evens A et al. Clin Can Res 2020). Little is known about how these therapeutic options impact patients' health-related quality of life (HRQL). To fill this gap, patient-reported outcomes (PROs) were administered to patients enrolled on E2408 to quantify symptom burden and effe

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Sarathbabu, Subbarayan, Satheesh K. Marimuthu, Souvik Ghatak, et al. "Induction of Apoptosis by Pierisin-6 in HPV Positive HeLa and HepG2 Cancer Cells is Mediated by the Caspase-3 Dependent Mitochondrial Pathway." Anti-Cancer Agents in Medicinal Chemistry 19, no. 3 (2019): 337–46. http://dx.doi.org/10.2174/1871520619666181127113848.

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Background: To explore the cytotoxic and apoptotic activity of the pierisin-6 protein in HPV HeLa and HepG2 cell lines. Methods: In this study, isolation, and purification of cytotoxic Prierisin-6 from the larvae of Pieris napi by affinity column chromatography techniques. Characterization of full-length mRNA of pierisin-6 gene was performed using 3’/5’ RACE PCR. The quantitative RT-PCR used to study the developmental stage-specific expression of pierisin-6 mRNA. The most effective concentration of Pierisin-6 protein was determined by measuring cell proliferation. Apoptosis was assessed using

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Tasho, Reep Pandi, Song-Hee Ryu, and Jae-Young Cho. "Effect of Sulfadimethoxine, Oxytetracycline, and Streptomycin Antibiotics in Three Types of Crop Plants—Root, Leafy, and Fruit." Applied Sciences 10, no. 3 (2020): 1111. http://dx.doi.org/10.3390/app10031111.

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(1) Background: Plants act as the natural sink for a variety of toxins in the environment, including veterinary antibiotics (VAs). The objective of this study was to evaluate the uptake and fate of sulfadimethoxine (SDZ), oxytetracycline (OTC), and streptomycin (STR) in lettuce (Lactuca sativa L.), carrot (Daucus carota), and pepper (Capsicum annum) grown in VAs amended soil. (2) Methods: 0, 50, and 100 mg kg−1 VA laced manure was applied in a sandy clay loam soil. (3) Results: 30-d (lettuce) and 60-d (carrot and pepper) greenhouse experiment showed that SDZ and OTC were taken up by all three

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Khafagy, El-Sayed, Ahmed Al Saqr, Hadil Faris Alotaibi, and Amr Selim Abu Lila. "Cytotoxic and Apoptotic Effect of Rubus chingii Leaf Extract against Non-Small Cell Lung Carcinoma A549 Cells." Processes 10, no. 8 (2022): 1537. http://dx.doi.org/10.3390/pr10081537.

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Rubus chingii is a traditional Chinese medicinal herbal that has been used since ancient times for its great dietary and medicinal values. Recent reports have underscored the promising cytotoxic effect of R. chingii extracts against a wide variety of cancer cells. Therefore, in the current study, we aim to explore the anticancer potential of the Rubus chingii ethanolic leaf extract (RcL-EtOH) against non-small cell lung cancer A549 cells. RcL-EtOH efficiently exerted a cytotoxic effect against A549 cells in a dose dependent manner, whilst, it exhibited non-significant toxic effects on normal m

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Reade, Julia. "Black Noise from the Break: Ma and Pa’s Black Radical Lyricism." Humanities 12, no. 2 (2023): 35. http://dx.doi.org/10.3390/h12020035.

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Kendrick Lamar’s 2022 track “We Cry Together” is, if nothing else, a masterful piece of wordplay and rhythm. Lamar manages to create a lyrical conversation that sounds both dialectical and diametric. Both the song and album are a definitive break from his earlier tenor that struck a mass appeal. A private conversation between two people, “We Cry Together”, insofar as it captures the intimate interiority of a couple, is also a break within the album itself. Textual renderings of Black performances cut away in ways similar to Lamar’s song or the soloist in a jazz ensemble, their breaks signifyin

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Gao, Ke, Chengfei Zhang, Yihong Tian, Sajid Naeem, Yingmei Zhang, and Yongmei Qi. "The role of endoplasmic reticulum stress in lead (Pb)-induced mitophagy of HEK293 cells." Toxicology and Industrial Health 36, no. 12 (2020): 1002–9. http://dx.doi.org/10.1177/0748233720971882.

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It is well-documented that lead (Pb) toxicity can affect almost all systems in living organisms. It can induce selective autophagy of mitochondria (mitophagy) by triggering reactive oxygen species production. Emerging evidence has suggested that Pb-induced autophagy can also be activated by the endoplasmic reticulum (ER) stress pathway. However, the interplay between ER stress and mitophagy remains to be elucidated. In this study, human embryonic kidney HEK293 cells were employed to investigate the role of ER stress in Pb-induced mitophagy. The results showed that the cell viability was decrea

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Dopkins, Nicholas, Kiesha Wilson, Kathryn Miranda, Prakash S. Nagarkatti, and Mitzi Nagarkatti. "Efficacy of cannabidiol treatment in experimental MS is due to immunosuppressive activity of myeloid cells in CNS downregulating recruitment of CD4+ T cells, proinflammatory chemokines and gasdermin D expression." Journal of Immunology 204, no. 1_Supplement (2020): 142.26. http://dx.doi.org/10.4049/jimmunol.204.supp.142.26.

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Abstract Cannabidiol (CBD) is a nonpsychoactive ingredient from Cannabis that has garnered attention in the medical community due to its anti-inflammatory properties and therapeutic potential. CBD has in particular become a popular alternative medicine among individuals with autoimmune disorders due to CBD lacking the side effects and costs associated with immunosuppressants. To better define how CBD inhibits inflammation, we studied the effects of orally administering CBD (20mg/kg) in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis. Using single cell RNA

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Hesami, Mohsen, Marco Pepe, and Andrew Maxwell Phineas Jones. "Morphological Characterization of Cannabis sativa L. Throughout Its Complete Life Cycle." Plants 12, no. 20 (2023): 3646. http://dx.doi.org/10.3390/plants12203646.

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This study extensively characterizes the morphological characteristics, including the leaf morphology, plant structure, flower development, and trichome features throughout the entire life cycle of Cannabis sativa L. cv. White Widow. The developmental responses to photoperiodic variations were investigated from germination to mature plant senescence. The leaf morphology showed a progression of complexity, beginning with serrations in the 1st true leaves, until the emergence of nine leaflets in the 6th true leaves, followed by a distinct shift to eight, then seven leaflets with the 14th and 15t

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Aziz, Khalid, Muhammad Ashraf, Farwa Batool, et al. "Investigation of the Cardio Protective Role of Justicia Adhotoda Leaf Extract Against Isoproterenol-Induced Myocardial Infarction in Rat Model." Scholars Academic Journal of Biosciences 13, no. 03 (2025): 327–34. https://doi.org/10.36347/sajb.2025.v13i03.004.

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Myocardial infarction (MI) continues to be a predominant cause of mortality globally and is characterized by restricted therapeutic alternatives and considerable adverse effects linked to traditional treatments. This study assessed the cardioprotective properties of Justicia adhatoda leaf extract against isoproterenol-induced myocardial infarction in rats at GC, University Faisalabad. A total of 32 albino Wistar rats were randomly allocated into four groups, with one group designated as the control and the remaining groups administered Justicia adhatoda leaf extract (400 mg/kg) or metoprolol (

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Zhuo, Xiaoneng, Shuji Shiozaki, Tsuneo Ogata, and Shosaku Horiuchi. "The Relationship between the Origin of Secondary Shoots on the Primary Shoot on the Induction of Tendrils and Inflorescenes, Signifying the End of the Transition Phase in V. ficifolia and Grape Vines." Engei Gakkai zasshi 72, no. 6 (2003): 539–45. http://dx.doi.org/10.2503/jjshs.72.539.

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Farooq, Zunaira, Muhammad Nouman Riaz, Muhammad Shoaib Farooq, et al. "Induction of Male Sterility by Targeted Mutation of a Restorer-of-Fertility Gene with CRISPR/Cas9-Mediated Genome Editing in Brassica napus L." Plants 11, no. 24 (2022): 3501. http://dx.doi.org/10.3390/plants11243501.

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Brassica napus L. (canola, oil seed rape) is one of the world’s most important oil seed crops. In the last four decades, the discovery of cytoplasmic male-sterility (CMS) systems and the restoration of fertility (Rf) genes in B. napus has improved the crop traits by heterosis. The homologs of Rf genes, known as the restoration of fertility-like (RFL) genes, have also gained importance because of their similarities with Rf genes. Such as a high non-synonymous/synonymous codon replacement ratio (dN/dS), autonomous gene duplications, and a possible engrossment in fertility restoration. B. napus c

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Pefanis, Gerasimos, Nikolaos Maniotis, Aikaterini-Rafailia Tsiapla, Antonios Makridis, Theodoros Samaras, and Mavroeidis Angelakeris. "Numerical Simulation of Temperature Variations during the Application of Safety Protocols in Magnetic Particle Hyperthermia." Nanomaterials 12, no. 3 (2022): 554. http://dx.doi.org/10.3390/nano12030554.

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Unavoidably, magnetic particle hyperthermia is limited by the unwanted heating of the neighboring healthy tissues, due to the generation of eddy currents. Eddy currents naturally occur, due to the applied alternating magnetic field, which is used to excite the nanoparticles in the tumor and, therefore, restrict treatment efficiency in clinical application. In this work, we present two simply applicable methods for reducing the heating of healthy tissues by simultaneously keeping the heating of cancer tissue, due to magnetic nanoparticles, at an adequate level. The first method involves moving

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Lucas, Edgar, David Campos-Gaona, and Olimpo Anaya-Lara. "Assessing the Impact of DFIG Synthetic Inertia Provision on Power System Small-Signal Stability." Energies 12, no. 18 (2019): 3440. http://dx.doi.org/10.3390/en12183440.

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Synthetic inertia provision through the control of doubly-fed induction generator (DFIG) wind turbines is an effective means of providing frequency support to the wider electrical network. There are numerous control topologies to achieve this, many of which work by making modifications to the DFIG power controller and introducing additional loops to relate active power to electrical frequency. How these many controller designs compare to one-another in terms of their contribution to frequency response is a much studied topic, but perhaps less studied is their effect on the small-signal stabili

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de Jesus Menezes-Filho, Noélio, Cleide dos Santos Souza, Tereza Cristina Silva Costa, et al. "Cytotoxicity of the Diterpene 14-O-Methyl-ryanodanol from Erythroxylum passerinum in an Astrocytic Cells Model." Natural Product Communications 9, no. 9 (2014): 1934578X1400900. http://dx.doi.org/10.1177/1934578x1400900906.

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Plant secondary metabolites, such as, specifically, alkaloids and terpenes, may present psychoactive properties that modify the function of the central nervous system (CNS) and induce neurotoxicity. Neurotoxicity involves the response of glial cells, mainly astrocytes, which play a fundamental role in the control of homeostasis of the CNS. Some Erythroxylum species are indigenous to the state of Bahia in Brazil. This study investigated the cytotoxic activity of the diterpene AEP-1, extracted from the fruit of E. passerinum in a GL-15 cell line, astrocytic, glial cells model. The effects on cel

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Pasricha, Gunisha, Sanjay Mukherjee, and Alok K. Chakrabarti. "Apoptotic and Early Innate Immune Responses to PB1-F2 Protein of Influenza A Viruses Belonging to Different Subtypes in Human Lung Epithelial A549 Cells." Advances in Virology 2018 (December 31, 2018): 1–12. http://dx.doi.org/10.1155/2018/5057184.

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PB1-F2 is a multifunctional protein and contributes to the pathogenicity of influenza A viruses. PB1-F2 is known to have strain and cell specific functions. In this study we have investigated the apoptotic and inflammatory responses of PB1-F2 protein from influenza viruses of diverse pathogenicities in A549 lung epithelial cells. Overexpression of PB1-F2 resulted in apoptosis and heightened inflammatory response in A549 cells. Comparison revealed that the response varied with each subtype. PB1-F2 protein from highly pathogenic H5N1 virus induced least apoptosis but maximum inflammatory respons

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Flowers, Christopher, Iris Isufi, Alex Francisco Herrera, et al. "Intratumoral G100 to induce systemic immune responses and abscopal tumor regression in patients with follicular lymphoma." Journal of Clinical Oncology 35, no. 15_suppl (2017): 7537. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.7537.

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7537 Background: Follicular lymphoma (FL) is an incurable malignancy with patients (pts) ultimately relapsing following standard therapies. Active immunotherapy has the potential to induce life-long host anti-tumor immunity and disease control. G100 consists of glucopyranosyl lipid-A (GLA), a TLR-4 agonist in a specific formulation. Preclinically, G100 activates dendritic cells, T cells and NK cells, and triggers systemic anti-tumor immunity. In Merkel Cell carcinoma pts, G100 administered intratumorally (IT) induced tumor inflammation and responses including a CR after G100 alone. This is the

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Eren, Barış, Aras Türkoğlu, Kamil Haliloğlu, et al. "Investigation of the Influence of Polyamines on Mature Embryo Culture and DNA Methylation of Wheat (Triticum aestivum L.) Using the Machine Learning Algorithm Method." Plants 12, no. 18 (2023): 3261. http://dx.doi.org/10.3390/plants12183261.

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Numerous factors can impact the efficiency of callus formation and in vitro regeneration in wheat cultures through the introduction of exogenous polyamines (PAs). The present study aimed to investigate in vitro plant regeneration and DNA methylation patterns utilizing the inter-primer binding site (iPBS) retrotransposon and coupled restriction enzyme digestion–iPBS (CRED–iPBS) methods in wheat. This investigation involved the application of distinct types of PAs (Put: putrescine, Spd: spermidine, and Spm: spermine) at varying concentrations (0, 0.5, 1, and 1.5 mM). The subsequent outcomes were

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Suzuki, Sakiko, Nathan A. Manalo, and Glen D. Raffel. "Ott1(Rbm15) Regulates p53 Levels during Oncogenic and Proliferative Stress." Blood 126, no. 23 (2015): 1189. http://dx.doi.org/10.1182/blood.v126.23.1189.1189.

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Abstract Ott1(Rbm15) is essential for engraftment and maintaining hematopoietic stem cell (HSC) quiescence during proliferative stress; therefore we sought to establish whether Ott1 has a regulatory role within the cell cycle. Ott1 knockout (KO) E14.5 murine embryonic fibroblasts (MEFs) were analyzed using BrdU labelling and demonstrated a higher basal proliferative rate. However, when subjected to oncogenic stress induced by infection with a constitutively active N-Ras expressing retrovirus, Ott1-deleted MEFs undergo immortalization and morphologic transformation in contrast to wild type (WT)

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Ahmad, Bilal, Jin Yao, Songlin Zhang, et al. "Genome-Wide Characterization and Expression Profiling of GASA Genes during Different Stages of Seed Development in Grapevine (Vitis vinifera L.) Predict Their Involvement in Seed Development." International Journal of Molecular Sciences 21, no. 3 (2020): 1088. http://dx.doi.org/10.3390/ijms21031088.

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Members of the plant-specific GASA (gibberellic acid-stimulated Arabidopsis) gene family have multiple potential roles in plant growth and development, particularly in flower induction and seed development. However, limited information is available about the functions of these genes in fruit plants, particularly in grapes. We identified 14 GASA genes in grapevine (Vitis vinifera L.) and performed comprehensive bioinformatics and expression analyses. In the bioinformatics analysis, the locations of genes on chromosomes, physiochemical properties of proteins, protein structure, and subcellular p

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Staskiewicz, Anna, Erica Wong, Michael Tucker, et al. "Cytotoxic and Apoptotic Effects of Pinostilbene and Bortezomib Combination Treatment on Human Multiple Myeloma Cells." International Journal of Molecular Sciences 24, no. 16 (2023): 12590. http://dx.doi.org/10.3390/ijms241612590.

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Multiple myeloma (MM) is a cancer of plasma cells in the bone marrow characterized by bone lesions, hypercalcemia, anemia, and renal failure. Bortezomib (BTZ), a common treatment for MM, is a proteasome inhibitor that induces apoptosis in MM cells. However, high doses of BTZ can be very toxic, signifying a need for a synergistic drug combination to improve treatment efficacy. Resveratrol (RES), a phenolic compound found in grapes, has been shown to inhibit MM cell growth. We sought to identify a synergistic combination of BTZ with a RES derivative and analyze the effects on reducing viability

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Asztalos, László, Mena Boktor, Miklós Kukuly, et al. "The Relationship Between Neuromuscular Block Depth and Airway Retroglossal Area: A Prospective, Nonrandomized, Observational Clinical Trial." Journal of Clinical Medicine 14, no. 12 (2025): 4374. https://doi.org/10.3390/jcm14124374.

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Background: Tracheal intubation and mechanical ventilation are facilitated by neuromuscular blocking agents. We investigated the effectiveness of subjective clinical evaluation of neuromuscular function on retroglossal area size, since it determines spontaneous ventilation adequacy following tracheal extubation. Secondarily, we correlated changes in retroglossal area and depth of neuromuscular block assessed during both respiratory phases using quantitative neuromuscular monitoring. Methods: Once mechanical ventilation was no longer needed, antagonists were used to reverse the neuromuscular bl

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Chou, Ting-Chao David. "Abstract A017: Computer simulation and quantification of the mass-action law-base pharmacodynamics parameters for anti-cancer and anti-viral therapeutics for single drugs and their combinations." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): A017. http://dx.doi.org/10.1158/1535-7163.targ-23-a017.

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Abstract The biophysical and biochemical fundamental principle of the mass-action law (MAL) was used as the solo model for broad-spectrum system analysis. These included linear and circular sequential analysis, pattern analysis, combinatorial analysis, and mathematical induction-deduction, for deriving unified general pharmacodynamics/biodynamics/combination index/and bioinformatics (PD/BD/CI/BI). The two unified general dose-effect dynamics theories are: “action” (Median-effect Eq., MEE) and “interaction” (Combination index Eq. CIE). All terms of MEE and CIE are dimensionless relativity ratio

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Chen, Bo-Xun, Tsai Lan Liao, Rong-Er Lu, Fei-Ting Hsu, and Yuan Chang. "Abstract 1117: To investigate the effect of fluoxetine combined with radiation therapy on hepatocellular carcinoma." Cancer Research 84, no. 6_Supplement (2024): 1117. http://dx.doi.org/10.1158/1538-7445.am2024-1117.

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Abstract Hepatocellular carcinoma (HCC) is a highly prevalent and lethal primary liver tumor. It commonly occurs in individuals with chronic liver diseases, such as hepatitis B or C related cirrhosis. Despite conventional treatments, such as surgery and chemotherapy, the prognosis for HCC remains poor. The optimal treatment for patients with HCC is contingent on various factors, including the size and location of the tumor, the functional capacity of their liver, and their overall health status. Radiation therapy (RT) is a prevalent cancer treatment modality that targets rapidly dividing tumor

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Kapoor, Sabeeta, and Roderick H. Dashwood. "Abstract 5712: Dietary polyphenols as BRD7 and 9 inhibitors for cancer interception." Cancer Research 82, no. 12_Supplement (2022): 5712. http://dx.doi.org/10.1158/1538-7445.am2022-5712.

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Abstract Introduction Epigenetic mechanisms play an important role in the initiation and advancement of colorectal cancer (CRC) and other malignancies due, in part, to deregulated bromodomain (BRD) functions1,2. We examined compounds from natural sources as BRD7/9 inhibitors, seeking lead candidates outside of the widely studied bromodomain and extraterminal (BET) family3. Methods As reported4,5, docking in silico involved STRAP and AutoDock Vina, ligand-protein interactions employed PDBePISA and LPC/CSU, and BROMOscan®-Bromodomain arrays were used to screen for BRD7/9 interacting compounds. B

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Zhang, Jie, та Ramalingam Kowsalya. "Daidzein Ameliorates Cerebral Ischemic-reperfusion Induced Neuroinflammation in Wistar Rats via Inhibiting NF-κB Signaling Pathway". Pharmacognosy Magazine 19, № 1 (2023): 85–96. http://dx.doi.org/10.1177/09731296221137378.

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Background Cerebral ischemia is a condition of acute brain damage due to the depletion of oxygenated blood supply to cerebral tissues. Daidzein is an isoflavonoid predominantly present in soya, Pueraria species, and red cloves. Traditional Chinese medicine utilizes daidzein to alleviate diseases such as inflammation, hyperglycemia, gastric diseases, allergies and aches. The neuroprotective effect of daidzein on cerebral ischemic conditions and its mechanism of action was not yet elucidated. Materials and Methods 24 healthy male adult Wistar rats were grouped into four and the control rats were

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Rifkin, Robert M., Rafat Abonour, Brian G. M. Durie, et al. "Treatment Patterns from 2009 to 2015 in Patients with Newly Diagnosed Multiple Myeloma in the United States: A Report from the Connect® MM Registry." Blood 128, no. 22 (2016): 4489. http://dx.doi.org/10.1182/blood.v128.22.4489.4489.

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Abstract Introduction: Between 2009 and 2015, use of novel therapies (immunomodulating drugs and proteasome inhibitors) in multiple myeloma (MM) increased. Regimens initiated during this time frame may help project near-term future treatment patterns. Connect® MM is the first and largest prospective, observational, US-based, multicenter disease registry designed to characterize treatment patterns and outcomes for patients (pts) with newly diagnosed MM (NDMM). Pts with NDMM were enrolled in 2 sequential cohorts from Sep 2009 to Apr 2016. This noninterventional registry did not prescribe or limi

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Gilzad-Kohan, Hamed, Shabnam Sani, and Mehdi Boroujerdi. "Calcitriol Reverses Induced Expression of Efflux Proteins and Potentiates Cytotoxic Activity of Gemcitabine in Capan-2 Pancreatic Cancer Cells." Journal of Pharmacy & Pharmaceutical Sciences 20 (August 24, 2017): 295. http://dx.doi.org/10.18433/j37w7r.

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Purpose. Efflux and influx proteins play a major role in chemo-resistance by affecting the net cellular uptake of anti-cancer drugs. Hence, alteration of the efflux and influx protein expression may result in variations of chemotherapeutics uptake and consequently cell death rate. The present study investigated the effects of pre-treatment of capan-2 pancreatic cancer cells with calcitriol, butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA) or silibinin on the induction of three major efflux proteins and the main gemcitabine influx protein. The influence of the pre-treatments on th

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Wilkinson, Emma A., Tong Wu, Gayoung Park, Yan-Hong Cui, Chuan He, and Yu-Ying He. "Abstract 227: Kethoxal-assisted single-stranded DNA sequencing (KAS-seq) reveals dynamic and temporal changes in transcription in response to UVB exposure." Cancer Research 82, no. 12_Supplement (2022): 227. http://dx.doi.org/10.1158/1538-7445.am2022-227.

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Abstract Skin cancer is the most common form of cancer, with over 5 million cases reported in 2021. UVB exposure derived from sunlight is the major carcinogenic driver of skin cancer and poses a major public health risk. In response to UVB exposure, keratinocytes must activate DNA repair pathways to avoid mutagenesis. In addition to DNA repair pathways, cells initiate well-coordinated DNA damage response pathways to facilitate the repair process, including arresting global transcription. Here we report the use of kethoxal-assisted single-strand DNA-Sequencing (KAS-Seq) technology to profile th

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Quaranto, Danielle, Michelle Carnazza, Nicole R. DeSouza, et al. "Abstract 2804: Long non-coding RNA LINC01614 regulates ferroptosis-mediated carcinogenic phenotypes in papillary thyroid cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 2804. https://doi.org/10.1158/1538-7445.am2025-2804.

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Abstract Papillary thyroid cancer (PTC) is the most common endocrine malignancy and is increasing annually in incidence by about 3%. PTC has a significantly higher prevalence in females of childbearing age and aggressiveness increases among males. Despite a high survival rate, disease recurrence and metastasis remain prominent issues-even decades after diagnosis. Therefore, the identification of prognostic biomarkers and actionable therapeutic targets remains a critical need. A newer class of epigenetic and regulatory molecules, known as long non-coding RNAs (lncRNAs), have demonstrated differ

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