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Journal articles on the topic 'SIKT'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Darling, Nicola J., Rachel Toth, J. Simon C. Arthur, and Kristopher Clark. "Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages." Biochemical Journal 474, no. 4 (2017): 521–37. http://dx.doi.org/10.1042/bcj20160646.

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The salt-inducible kinases (SIKs) control a novel molecular switch regulating macrophage polarization. Pharmacological inhibition of the SIKs induces a macrophage phenotype characterized by the secretion of high levels of anti-inflammatory cytokines, including interleukin (IL)-10, and the secretion of very low levels of pro-inflammatory cytokines, such as tumour necrosis factor α. The SIKs, therefore, represent attractive new drug targets for the treatment of macrophage-driven diseases, but which of the three isoforms, SIK1, SIK2 or SIK3, would be appropriate to target remains unknown. To addr

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2

Jacobsen, Geir. "Hva betyr amming på lengre sikt?" Tidsskrift for Den norske legeforening 129, no. 7 (2009): 612. http://dx.doi.org/10.4045/tidsskr.09.0284.

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3

Friis, Karsten. "Blikket i glasskulen: NATO de neste 70 år." Internasjonal Politikk 77, no. 1 (2019): 117. http://dx.doi.org/10.23865/intpol.v77.1624.

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Hvordan vil det gå med NATO? Vil alliansen overleve de neste 70 år? Hvilke utfordringer vil alliansen i så fall måtte håndtere? Artikkelen spekulerer på fremtiden og forsøker å se inn i glasskulen og peke på noen mulige utviklingstrekk. Jeg argumenterer at NATO trolig vil bestå, men dens relevans vil avhenge av hvor tilpasningsdyktig den er i forhold til nye utfordringer. I tillegg må verdifellesskapet og solidariteten bestå om alliansen skal være noe mer enn en papirtiger. På kort sikt er det de transatlantiske relasjonene som bekymrer mest, mens klimaendringer og migrasjon, samt den raske di

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4

Necander—Redell, Lena. "PÄ LÄNG SIKT. FEM FALLSTUDIER AV TIDIG PERSONLIGHETSSTÄRNING I LÄNGTIDSPSYKOTERAPI." Scandinavian Psychoanalytic Review 25, no. 1 (2002): 67–68. http://dx.doi.org/10.1080/01062301.2002.10592728.

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5

Bye, Karstein. "Situasjonen i Norge etter Tsjernobyl og tiltak som iverksettes." Rangifer 6, no. 1 (1986): 65. http://dx.doi.org/10.7557/2.6.1-app.604.

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M&aring;let for alle fors&oslash;kene er en praktisk anvendelse i reindriften. Foring med kraftfor, med slikkestein rik p&aring; kalium som tilskudd, synes &aring; v&aelig;re det mest aktuelle tiltaket forel&oslash;pig. P&aring; sikt (neste slaktesesong) kan bruk av ferrocyanider bli det mest effektive tiltak for &aring; hindre opptak av cesium.

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6

Bjering, Ragnar, and Vaska Vandevska-Radunovic. "Hvor stabil er kjeveortopedisk behandling på sikt, og hvilken betydning har retainere?" Aktuel Nordisk Odontologi 45, no. 01 (2020): 166–78. http://dx.doi.org/10.18261/issn.2058-7538-2020-01-14.

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7

Jin, Hyun Yong, Yanyan Tudor, Kaylee Choi, et al. "High-Throughput Implementation of the NanoBRET Target Engagement Intracellular Kinase Assay to Reveal Differential Compound Engagement by SIK2/3 Isoforms." SLAS DISCOVERY: Advancing the Science of Drug Discovery 25, no. 2 (2019): 215–22. http://dx.doi.org/10.1177/2472555219893277.

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The real-time quantification of target engagement (TE) by small-molecule ligands in living cells remains technically challenging. Systematic quantification of such interactions in a high-throughput setting holds promise for identification of target-specific, potent small molecules within a pathophysiological and biologically relevant cellular context. The salt-inducible kinases (SIKs) belong to a subfamily of the AMP-activated protein kinase (AMPK) family and are composed of three isoforms in humans (SIK1, SIK2, and SIK3). They modulate the production of pro- and anti-inflammatory cytokines in

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8

Darling, Nicola J., and Philip Cohen. "Nuts and bolts of the salt-inducible kinases (SIKs)." Biochemical Journal 478, no. 7 (2021): 1377–97. http://dx.doi.org/10.1042/bcj20200502.

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The salt-inducible kinases, SIK1, SIK2 and SIK3, most closely resemble the AMP-activated protein kinase (AMPK) and other AMPK-related kinases, and like these family members they require phosphorylation by LKB1 to be catalytically active. However, unlike other AMPK-related kinases they are phosphorylated by cyclic AMP-dependent protein kinase (PKA), which promotes their binding to 14-3-3 proteins and inactivation. The most well-established substrates of the SIKs are the CREB-regulated transcriptional co-activators (CRTCs), and the Class 2a histone deacetylases (HDAC4/5/7/9). Phosphorylation by

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9

Holgersson, Stefan. "Yta och innehåll i Polisens informationskampanjer." HumaNetten, no. 46 (June 16, 2021): 7–31. http://dx.doi.org/10.15626/hn.20214602.

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Förtroendet för Polisen har ökat de senaste åren, trots att ett flertal problem kopplat till polisens sätt att bedriva sin verksamhet fått stor uppmärksamhet i media. Det finns flera faktorer som pekar på att Polismyndighetens sätt att kommunicera varit gynnsam för tilliten till organisationen, men att olika förhållanden inte presenterats på ett rättvisande sätt. Istället har Polisen framställts på ett mer positivt sätt jämfört med hur verksamheten i realiteten fungerar. Det är avgörande att det finns en stor tillit till polisen i ett samhälle, och det finns andra faktorer som kan motivera Po

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10

Tamnes, Rolf. "Småstatsrealisme i 70 år." Internasjonal Politikk 77, no. 1 (2019): 49. http://dx.doi.org/10.23865/intpol.v77.1617.

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Norges tilslutning til Atlanterhavspakten i 1949 markerte et vendepunkt i norsk sikkerhetspolitikk. Norsk sikkerhet kom til å hvile på NATO, med USA som fremste støttemakt. I den senere tid er det transatlantiske samarbeidet kommet under press, og det stilles spørsmål ved den amerikanske garantien. Det kan medføre en alvorlig utfordring for norsk sikkerhet. På lang sikt vil det kunne vokse frem et strategisk partnerskap i Nord-Europa og Norden, som kan bli en bærebjelke for norsk sikkerhetspolitikk og markere et nytt vendepunkt. Norges strategiske omgivelser er omskiftelige. Samtidig finnes no

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11

Heggstad, Eirik, Esben Bø, and Dag Lenvik. "Behandling av reinkalver med ivermectin første levehøst. Effekt på levendevekter andre levehøst." Rangifer 6, no. 1 (1986): 77. http://dx.doi.org/10.7557/2.6.1-app.610.

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Reinen lever i et sv&aelig;rt s&aring;rbart milj&oslash;, hvor sm&aring; inngrep kan gi uante f&oslash;lger p&aring; lengre sikt. Innf&oslash;ring av medikamentbruk i en n&aelig;ring som tradisjonelt har klart seg uten medf&oslash;rer derfor et betydelig ansvar. For eksempel vil bruk av ivermectin p&aring; flokker fra d&aring;rlige, overbelastede beiter sannsynligvis gi bra effekt, men samtidig kan det bidra til &aring; kamuflere problemer som kunne l&oslash;ses p&aring; annen m&aring;te, f.eks. ved omlegging av flokkstruktur og slakt

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12

Ackesjö, Helena. "Borde svenska lärare bli mer franska?" Pedagogisk forskning i Sverige 24, no. 2 (2019): 74–87. http://dx.doi.org/10.15626/pfs24.02.04.

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Under början av 2019 förs en intensiv debatt i nationella medier om lärare, lärarauktoritet och lärararbetets gränser. I TV, radio och tidningar lyfts exempel på händelser från olika delar av landet fram i ljuset. Ett sådant är elevers upplevda kränkningar, en diskussion som ställs i relation till lärares auktoritet men framför allt till lärares handlingsutrymme. I denna text diskuteras lärarprofessionens gränser genom Frykmans (1998) teoretiska lins. I texten jämförs exempel från den svenska skolan med exempel från den franska i avsikt att föra en kontrasterande och teoretisk diskussion

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13

Liu, Ying, Victoria Poon, Graciela Sanchez-Watts, Alan G. Watts, Hiroshi Takemori, and Greti Aguilera. "Salt-Inducible Kinase Is Involved in the Regulation of Corticotropin-Releasing Hormone Transcription in Hypothalamic Neurons in Rats." Endocrinology 153, no. 1 (2012): 223–33. http://dx.doi.org/10.1210/en.2011-1404.

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Activation of CRH transcription requires phosphorylation of cAMP response element-binding protein (CREB) and translocation of the CREB coactivator, transducer of regulated CREB activity (TORC) from cytoplasm to nucleus. In basal conditions, transcription is low because TORC remains in the cytoplasm, inactivated by phosphorylation through Ser/Thr protein kinases of the AMP-dependent protein kinases (AMPK) family, including salt-inducible kinase (SIK). To determine which kinase is responsible for TORC phosphorylation in CRH neurons, we measured SIK1 and SIK2 mRNA in the hypothalamic paraventricu

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14

Taub, Mary. "Salt Inducible Kinase Signaling Networks: Implications for Acute Kidney Injury and Therapeutic Potential." International Journal of Molecular Sciences 20, no. 13 (2019): 3219. http://dx.doi.org/10.3390/ijms20133219.

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A number of signal transduction pathways are activated during Acute Kidney Injury (AKI). Of particular interest is the Salt Inducible Kinase (SIK) signaling network, and its effects on the Renal Proximal Tubule (RPT), one of the primary targets of injury in AKI. The SIK1 network is activated in the RPT following an increase in intracellular Na+ (Na+in), resulting in an increase in Na,K-ATPase activity, in addition to the phosphorylation of Class IIa Histone Deacetylases (HDACs). In addition, activated SIKs repress transcriptional regulation mediated by the interaction between cAMP Regulatory E

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15

Cai, Yujun, Xue-Lin Wang, Jinny Lu, Xin Lin, Jonathan Dong, and Raul J. Guzman. "Salt-Inducible Kinase 3 Promotes Vascular Smooth Muscle Cell Proliferation and Arterial Restenosis by Regulating AKT and PKA-CREB Signaling." Arteriosclerosis, Thrombosis, and Vascular Biology 41, no. 9 (2021): 2431–51. http://dx.doi.org/10.1161/atvbaha.121.316219.

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Objective: Arterial restenosis is the pathological narrowing of arteries after endovascular procedures, and it is an adverse event that causes patients to experience recurrent occlusive symptoms. Following angioplasty, vascular smooth muscle cells (SMCs) change their phenotype, migrate, and proliferate, resulting in neointima formation, a hallmark of arterial restenosis. SIKs (salt-inducible kinases) are a subfamily of the AMP-activated protein kinase family that play a critical role in metabolic diseases including hepatic lipogenesis and glucose metabolism. Their role in vascular pathological

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16

Park, Minjeong, Chika Miyoshi, Tomoyuki Fujiyama, et al. "Increased sleep need in mice lacking the PKA phosphorylation site in SIK1 and SIK2." IBRO Reports 6 (September 2019): S74. http://dx.doi.org/10.1016/j.ibror.2019.07.245.

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17

Danell, Öje. "Optimal produktion." Rangifer 19, no. 4 (1999): 125. http://dx.doi.org/10.7557/2.19.4.1606.

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<p>Optimal Production in Reindeer Husbandry.</p><p>There are three ways to optimize the reindeer herd: 1) Adjusting the reindeer number to pasture resources. 2) Keeping as many productive animals in the herd as possible through slaughter. 3) Increasing the herd quality through selection.</p><p>Renhjorden b&ouml;r optimeras s&aring; att den fungerar som en "sk&ouml;rdeapparat" for bete och l&auml;mnar st&ouml;rsta m&ouml;jliga bidrag till f&ouml;rs&ouml;rjningen f&ouml;r dem som lever av rensk&ouml;tsel. Det finns minst tre s

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18

Wang, Lei, Chunhong Chang, Zhouqi Liu, Jin Huang, Cong Liu, and Chunxiang Liu. "A Medical Image Fusion Method Based on SIFT and Deep Convolutional Neural Network in the SIST Domain." Journal of Healthcare Engineering 2021 (April 21, 2021): 1–8. http://dx.doi.org/10.1155/2021/9958017.

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The traditional medical image fusion methods, such as the famous multi-scale decomposition-based methods, usually suffer from the bad sparse representations of the salient features and the low ability of the fusion rules to transfer the captured feature information. In order to deal with this problem, a medical image fusion method based on the scale invariant feature transformation (SIFT) descriptor and the deep convolutional neural network (CNN) in the shift-invariant shearlet transform (SIST) domain is proposed. Firstly, the images to be fused are decomposed into the high-pass and the low-pa

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19

Hollstein, Pablo E., Lillian J. Eichner, Sonja N. Brun, et al. "The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC." Cancer Discovery 9, no. 11 (2019): 1606–27. http://dx.doi.org/10.1158/2159-8290.cd-18-1261.

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20

LeBlanc, Anne-Marie, Richard Fortier, Michel Allard, Calin Cosma, and Sylvie Buteau. "Seismic cone penetration test and seismic tomography in permafrost." Canadian Geotechnical Journal 41, no. 5 (2004): 796–813. http://dx.doi.org/10.1139/t04-026.

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Two high-resolution multi-offset vertical seismic profile (VSP) surveys were carried out in a permafrost mound near Umiujaq in northern Quebec, Canada, while performing seismic cone penetration tests (SCPT) to study the cryostratigraphy and assess the body waves velocities and the dynamic properties of warm permafrost. Penetrometer-mounted triaxial accelerometers were used as the VSP receivers, and a swept impact seismic technique (SIST) source generating both compressional and shear waves was moved near the surface following a cross configuration of 40 seismic shot-point locations surrounding

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21

Widiati, Bidarita. "HOMONYM IN MERIAQ MERIKU DIALECT IN KAWO CENTRAL LOMBOK." Journal of Languages and Language Teaching 7, no. 1 (2020): 64. http://dx.doi.org/10.33394/jollt.v7i1.1440.

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This research is aimed at finding and describing the Homonym words in Meriaq Meriku Dialect in Kawo Central Lombok. Ambiguity may occur in interpreting the meaning in the form of homonymy because Homonym word has more than one meaning. The method which is applied here is a descriptive qualitative approach, by finding some homonym word and describing them. There are ten words in Meriaq Meriku Dialect which categorized as homonym. They are mangan [mangΛn], gigi [gIgI] , genit [gƐnit] , siku [sikƲ], paku [pΛkƲ], poto [p0t0] , sangkok [saȠgk0k], daun [dawƲn] , semen [semEn], and bau [bΛƲ].

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22

Lin, Shan, Yusuke Tarumoto, Jinhua Wang, et al. "Targeting Salt-Inducible Kinase 3 As a Therapeutic Approach for Acute Myeloid Leukemia." Blood 134, Supplement_1 (2019): 3941. http://dx.doi.org/10.1182/blood-2019-125278.

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Acute myeloid leukemia (AML) remains a devastating illness, with a clear need for the development of novel anti-leukemic therapy. CRISPR-Cas9 functional genomic screens have revealed hundreds of genetic vulnerabilities in AML cells, which can be leveraged to nominate clinically actionable targets. Our previous CRISPR screens in AML cell lines identified Salt-Inducible Kinase 3 (SIK3) as an essential gene for a subset of AML cells with high expression of the oncogenic transcription factor MEF2C, such as AMLs harboring Mixed Lineage Leukemia (MLL)-fusion proteins. Mechanistically, we have shown

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23

Bell, Cameron M., and Robert A. Dieterich. "Translocation of reindeer from South Georgia to the Falkland Islands." Rangifer 30, no. 1 (2010): 1–9. http://dx.doi.org/10.7557/2.30.1.247.

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This report describes the first translocation of reindeer Rangifer tarandus from South Georgia to the Falkland Islands, in the South Atlantic Ocean. Reindeer were introduced from Norway to the subantarctic island of South Georgia on three occasions in the early 1900s by Norwegian whalers, and today they exist as two discrete herds, numbering approximately 2600 individuals in total. Because of concerns over the impact on native vegetation, the long-term eradication of reindeer from South Georgia has recently been proposed. A translocation of reindeer to the Falkland Islands was undertaken in 20

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24

Niemi, Jarkko K., and Marja-Liisa Sevón-Aimonen. "Lihasikalassa kiinnitettävä huomiota porsaserän laatuun ja sikalan tyhjennystapaan." Suomen Maataloustieteellisen Seuran Tiedote, no. 26 (January 31, 2010): 1–6. http://dx.doi.org/10.33354/smst.76846.

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Teurastuksen ajoitus on tärkeä lihasikojen kasvatuksen kannattavuuteen vaikuttava tekijä. Liian aikaisinteurastettaessa osa sian kasvupotentiaalista jää käyttämättä ja liian myöhään teurastettaessa sian paras kasvupotentiaalion jo käytetty. Sikojen kasvukyvyssä ja siten teuraspainoissa voi kuitenkin olla suuria eroja,jolloin tuottajan ongelmana on valita koko kasvatuserän kannalta optimaalinen teurastusajankohta. Teurastuksenajoituksen taloudellista merkitystä lisää se, että teurastamot maksavat alempaa hintaa niin sanotunkärkipainovälin ylittävistä tai alittavista ruhoista. Ruhojen hinnoittel

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25

Ritson, Katie. "Silt." Environmental Humanities 11, no. 2 (2019): 461–64. http://dx.doi.org/10.1215/22011919-7754556.

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26

Yengui, Ameni, and Mahmoud Neji. "SIAT." Journal on Computing and Cultural Heritage 13, no. 3 (2020): 1–16. http://dx.doi.org/10.1145/3383781.

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27

Trundle, Elizabeth. "Sift." Prairie Schooner 86, no. 1 (2012): 85–100. http://dx.doi.org/10.1353/psg.2012.0018.

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28

Şekeroğlu, Kazim, and Ömer Muhammet Soysal. "Comparison of SIFT, Bi-SIFT, and Tri-SIFT and their frequency spectrum analysis." Machine Vision and Applications 28, no. 8 (2017): 875–902. http://dx.doi.org/10.1007/s00138-017-0868-9.

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29

McLeod, W. H. "Sikh Fundamentalism." Journal of the American Oriental Society 118, no. 1 (1998): 15. http://dx.doi.org/10.2307/606295.

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30

Starostzik, Christine. "Therapieansprechen sinkt." Der Deutsche Dermatologe 67, no. 11 (2019): 870. http://dx.doi.org/10.1007/s15011-019-2705-0.

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31

Doelfs, Guntram. "Morbidität sinkt." kma - Klinik Management aktuell 20, no. 02 (2015): 11. http://dx.doi.org/10.1055/s-0036-1577616.

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32

King, Brian. "Silt crucial." New Scientist 214, no. 2865 (2012): 32. http://dx.doi.org/10.1016/s0262-4079(12)61289-5.

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33

Waldrop, Rosmarie. "Urgent Silt." Iowa Review 26, no. 2 (1996): 199–200. http://dx.doi.org/10.17077/0021-065x.4662.

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34

Tino, Anita, Caroline Collange, and André Seznec. "SIMT-X." ACM Transactions on Architecture and Code Optimization 17, no. 2 (2020): 1–23. http://dx.doi.org/10.1145/3392032.

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35

Koczorek, Michael. "Mortalitätsrisiko sinkt." MMW - Fortschritte der Medizin 156, no. 10 (2014): 76. http://dx.doi.org/10.1007/s15006-014-3090-y.

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36

Wenderlein, J. Matthias. "Diabetesinzidenz sinkt!" Info Diabetologie 4, no. 3 (2010): 22. http://dx.doi.org/10.1007/bf03372479.

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37

Brubakk, Katrin Glatz. "Bli sint!" Samtiden 129, no. 01 (2021): 60–65. http://dx.doi.org/10.18261/issn1890-0690-2021-01-08.

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38

Ricarte, Florante R., Carole Le Henaff, Victoria G. Kolupaeva, Thomas J. Gardella, and Nicola C. Partridge. "Parathyroid hormone(1–34) and its analogs differentially modulate osteoblastic Rankl expression via PKA/SIK2/SIK3 and PP1/PP2A–CRTC3 signaling." Journal of Biological Chemistry 293, no. 52 (2018): 20200–20213. http://dx.doi.org/10.1074/jbc.ra118.004751.

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39

Walkinshaw, Donald R., Ryan Weist, Go-Woon Kim, et al. "The Tumor Suppressor Kinase LKB1 Activates the Downstream Kinases SIK2 and SIK3 to Stimulate Nuclear Export of Class IIa Histone Deacetylases." Journal of Biological Chemistry 288, no. 13 (2013): 9345–62. http://dx.doi.org/10.1074/jbc.m113.456996.

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40

Sunita and PC Sehgal. "Availability of Open Access Books on Sikh Religion and Sikh History over Sikh Book Club." Library Progress (International) 38, no. 2 (2018): 241. http://dx.doi.org/10.5958/2320-317x.2018.00025.9.

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41

Bochaton, Sidonie. "Sixt-Fer-à-Cheval (Haute-Savoie). Abbaye de Sixt." Archéologie médiévale, no. 48 (December 20, 2018): 279. http://dx.doi.org/10.4000/archeomed.17214.

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42

Madan, T. N., and W. H. McLeod. "Who Is a Sikh? The Problem of Sikh Identity." Journal of the American Oriental Society 111, no. 2 (1991): 418. http://dx.doi.org/10.2307/604059.

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43

Bochaton, Sidonie. "Sixt-Fer-à-Cheval (Haute-Savoie). Abbaye de Sixt." Archéologie médiévale, no. 46 (December 1, 2016): 233. http://dx.doi.org/10.4000/archeomed.7345.

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44

Xu, Yao, Shu Cai Li, Xiao Zhang, Bin Yan, and Chun Mei Zhu. "Dynamic Consolidation Test Study on Silt and Silt Soil." Applied Mechanics and Materials 90-93 (September 2011): 537–41. http://dx.doi.org/10.4028/www.scientific.net/amm.90-93.537.

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A dynamic consolidation model of double layered foundation of saturated soil and unsaturated soil is proposed. Mechanism of dynamic compaction treating on double layered foundation is studied by the model. On the base of the mechanism a new technology called soil-mound dynamic consolidation can be applied to treat the ground of saturated silt and silty clay with high groundwater level. The water-pore pressure test, static cone penetration test, settlement plate test are applied to evaluate that of the new technology with different construction parameters. The treatment effect is more remarkabl

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45

Dellinger, Flora, Julie Delon, Yann Gousseau, Julien Michel, and Florence Tupin. "SAR-SIFT: A SIFT-Like Algorithm for SAR Images." IEEE Transactions on Geoscience and Remote Sensing 53, no. 1 (2015): 453–66. http://dx.doi.org/10.1109/tgrs.2014.2323552.

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46

Winter, J. M. van. "C.J.C. Broer, M.W.J. de Bruijn, De eerste kerken in Utrecht: Sint-Thomas, Sint-Salvator, Sint-Maarten." BMGN - Low Countries Historical Review 111, no. 4 (1996): 533. http://dx.doi.org/10.18352/bmgn-lchr.4353.

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47

Jung, Sung Hoon. "Touch Recognition based on SIFT Algorithm." Journal of the Korea Society of Computer and Information 18, no. 11 (2013): 69–75. http://dx.doi.org/10.9708/jksci.2013.18.11.069.

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48

BORRAS, A. "Ut unum sint." Ephemerides Theologicae Lovanienses 72, no. 4 (1996): 349–70. http://dx.doi.org/10.2143/etl.72.4.504842.

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49

Gibbes, C. "Wetgeving Sint Maarten." Caribisch Juristenblad 9, no. 2 (2020): 238–40. http://dx.doi.org/10.5553/cjb/221132662020009002014.

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Buczynski, Sandy, Jennifer Gorsky, Lynn McGrath, and Perla Myers. "Sift like Eratosthenes." Teaching Children Mathematics 18, no. 2 (2011): 110–18. http://dx.doi.org/10.5951/teacchilmath.18.2.0110.

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