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Dissertations / Theses on the topic 'SILICO ANALYSIS'

Author: Grafiati
Published: 11 September 2023

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1

Chen, Ming. "In silico systems analysis of biopathways." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972067272.

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2

Valejev, Najl V. "In silico analysis of signal transduction proteins." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432258.

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3

Ferreira, Susana Duarte Barros Lopes. "In silico analysis of regenerating spinal cord transcriptomes." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/19034.

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Mestrado em Biomedicina Molecular<br>As lesões na medula espinal são uma desordem neurológica comum com um impacto significativo na sociedade moderna do ponto de visto físico, psicosocial e socioeconómico. Apesar de vários vertebrados serem capazes de regenerar lesões do sistema nervoso central, nomeadamente da medula espinal (ex. Rã, Peixe-zebra, Salamandra), está bem estabelecido que os seres humanos, e outros mamíferos adultos, não o conseguem fazer. Como tal, em consequência de lesões traumáticas no cérebro ou medula espinal, há incapacidade dos axónios crescerem extensivamente no tecido
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4

Bassot, Claudio. "In silico analysis of membrane transport/permeability mechanisms." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3425730.

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Lipid membranes are a fundamental component of living cells, mediating the physical separation of intracellular components from the external environment, as well as the different cellular organelles from cytoplasm. Transmembrane transport proteins confer permeability to lipid membranes, which is essential for nutrient translocation and energy metabolism. Crystallography of transmembrane proteins is a particularly challenging problem. Due to their natural localization and chemical properties only a limited number of structures are to date available at atomic resolution. In silico analysis can b
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5

Bellora, Pereyra Nicolás. "In silico analysis of regulatory motifs in gene promoters." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7202.

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Regulation of gene transcription is a complex process involving many different proteins, some of which bind in a sequence-specific manner to DNA motifs in the gene promoter. The need to maintain specific interactions between transcription factors and proteins involved in the RNA polymerase II complex is expected to impose constrains on the relative position and spacing of the interacting DNA motifs. The present work includes the development of a novel approach to identify motifs that show a preferential location in DNA sequences and the implementation of a public web application called PEAKS.
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6

Behera, Jyoti, and Aruna Kilaru. "Comparative in Silico Analysis of WRINKLED1 Paralogs in Angiosperms." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/7723.

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Behera, Jyoti, Shina Bhatia, and Aruna Kilaru. "Comparative in Silico Analysis of WRINKLED1 Paralogs in Angiosperms." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/7724.

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WRINKLED 1(WRI1), a member of AP2/EREBP class of transcription factors regulates carbon allocation between glycolytic and fatty acid biosynthetic pathway. Additionally, among the four WRI1 paralogs in Arabidopsis, WRI3 and 4 but not WRI2, are also able to increase fatty acid content in different tissues. While the role of WRI1 is well established in seeds, the potential or WRI1 or its paralogs as master regulators in oilrich nonseed tissues is poorly understood. Recent transcriptome studies of avocado (Persea americana) mesocarp revealed that the ortholog of WRI2, along with WRI1 and WRI3 was
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8

Azevedo, Ana do Carmo Ramalho Moreira. "Familial amyloid polyneuropathy: TTR sequencing and "in silico" analysis." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/15608.

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Mestrado em Biomedicina Molecular<br>Familial amyloid polyneuropathy (FAP) or paramiloidosis is an autosomal dominant neurodegenerative disease with onset on adult age that is characterized by mutated protein deposition in the form of amyloid substance. FAP is due to a point alteration in the transthyretin (TTR) gene and until now more than 100 amyloidogenic mutations have been described in TTR gene. FAP shows a wide variation in age-at-onset (AO) (19-82 years, in Portuguese cases) and the V30M mutation often runs through several generation of asymptomatic carriers, before expressing in a prob
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9

Huang, Yi. "In silico analysis of a novel human coronavirus, coronavirus HKU1." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39793825.

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10

Saeed, Hanaa. "«In planta» and «in silico» analysis of soybean lectin promoters." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18806.

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Soybean seed lectin, Le1, is specifically located in seeds of soybean, Glycine max, (L.) Merr., due to its promoter. Gene homologues of Le1 were previously identified as possibly located in other parts of soybean. We cloned two novel promoters from these genes, and show that they drive reporter gene expression in transgenic Arabidopsis. A total of 1.3kb was isolated from each of the Le2 and Le3 5' promoter regions and fused with the GUS reporter gene. A previously cloned Le1 5' promoter was used as a control and the constructs were introduced into Arabidospis. GUS expression in transformed pla
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11

Huang, Yi, and 黃弋. "In silico analysis of a novel human coronavirus, coronavirus HKU1." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39793825.

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12

behera, Jyoti Ranjan, Shina Bhatia, and Aruna Kilaru. "Comparative in silico analysis of WRINKLED 1 paralogs in angiosperms." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/10.

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WRINKLED 1(WRI1), a member of AP2/EREBP class of transcription factors regulates carbon allocation between glycolytic and fatty acid biosynthetic pathway. Additionally, among the four WRI1 paralogs in arabidopsis, WRI3 and 4 but not WRI2, are also able to increase fatty acid content in different tissues. While the role of WRI1 is well established in seeds, the potential or WRI1 or its paralogs as master regulators in oil-rich nonseed tissues is poorly understood. Recent transcriptome studies of avocado (Persea americana) mesocarp revealed that the ortholog of WRI2, along with WRI1 and WRI3 was
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13

Safina, Melania. "DNA barcoding of Pleuronectiformes: in silico analysis and development of markers." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/12259/.

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DNA barcoding is a method used for the identification and discovery of animal species. It usually involved a 648 base pair fragment of the mitochondrial cytochrome c oxidase subunit I, known as COI. This work is focused on the study of the genetic identification in the families belonging to the order Pleuronectiformes, commonly known as flatfish, and the accuracy of the genetic marker most used for the study of their DNA barcodes. The results indicate possible existence of taxonomical mistakes because several families do not show a gap between maximum intraspecific distance - which is the maxi
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14

Zelensky, Alex N., and Alex Zelensky@anu edu au. "In silico analysis of C-type lectin domains’ structure and properties." The Australian National University. The John Curtin School of Medical Research, 2005. http://thesis.anu.edu.au./public/adt-ANU20050318.185314.

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Members of the C-type lectin domain (CTLD) superfamily are metazoan proteins functionally important in glycoprotein metabolism, mechanisms of multicellular integration and immunity. This thesis presents the results of several computational and experimental studies of the CTLD structure, function and evolution.¶ Core structural properties of the CTLD fold were explored in a comparative analysis of the 37 distinct CTLD structures available publicly, which demonstrate significant structural conservation despite low or undetectable sequence similarity. Pairwise structural alignments of all CTLD s
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15

Zelensky, Alex N. "In silico analysis of C-type lectin domains' structure and properties /." View thesis entry in Australian Digital Theses Program, 2004. http://thesis.anu.edu.au/public/adt-ANU20050318.185314/index.html.

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Thesis (Ph.D.)--Australian National University, 2004.<br>"This CD contains the software (mostly written in Perl) used for comparative structure analysis reported in Chapter 4 (str_comp directory), and for the CTLD database system described in Chapter 2 (CTLD_DB directory)."
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16

MACCESI, Martina. "In silico protein modelling applied to the identification of new therapeutic agents." Doctoral thesis, Università degli studi di Ferrara, 2019. http://hdl.handle.net/11392/2488106.

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This thesis collects the results of three different research projects carried out in collaboration with the University of Parma. In chapter 2 the identification and characterization of antimicrobial compounds active as protein-protein interaction inhibitors of bacterial RNA polymerase subunit β' and transcription initiation factor σ is described. This peculiar protein-protein interaction has been identified as a promising target for antibacterial research and some small molecules were identified as disruptors of this interaction. In this project, a virtual screening campaign, aimed to the iden
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17

Liggi, Sonia. "Extending in silico mechanism-of-action analysis by annotating targets with pathways." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708512.

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18

Harding, Simon D. "Database analysis of protein-peptide interactions and in silico screening for peptidomimetics." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/10935.

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A potential path to the development of small-molecule inhibitors is to identify small-molecules that mimic the interactions of short peptides with proteins. The present study uses Perl scripts and a MySQL database to build a unique dataset of 258 protein-peptide interactions (ProPep) from structures contained in the Protein Data Bank. The physiochemical and structural nature of protein-peptide interfaces were analysed in part using a novel amino acid pictogram analysis alongside accessible surface area, residue pairing and amino acid composition analysis. The results indicate that, for the pep
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19

Tiwari, Vijay, Derek Stuffle, and Aruna Kilaru. "Identification and In-Silico Analysis of Fatty Acid Amide Hydrolases in Tomato." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/4797.

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N-acylethanolamines (NAEs) are a family of signaling lipids derived from a minor membrane lipid constituent N-acylphosphatidylethanolamine (NAPE). In Arabidopsis, NAE mediates physiological functions such as seedling growth, flowering, and response to stress via abscisic acid (ABA) –dependent and –independent signaling pathways. The function of NAEs is terminated by a highly conserved fatty acid amide hydrolase (FAAH). Studies in model plant Arabidopsis showed the significant role of NAEs that makes it relevant to elucidate the conserved metabolic pathway of NAEs in crop species such as tomato
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20

Sompallae, Ramakrishna Rao. "In silico analysis of pathways targeted by EBV infection and malignant transformation." Stockholm : Karolinska institutet, 2009. http://diss.kib.ki.se/2009/978-91-7409-693-4/.

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21

Benediktsson, Elís Ingi. "Detection and analysis of megasatellites in the human genome using in silico methods." Thesis, University of Skövde, School of Humanities and Informatics, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-961.

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<p>Megasatellites are polymorphic tandem repetitive sequences with repeat-units longer than or equal to 1000 base pairs. The novel algorithm Megasatfinder predicts megasatellites in the human genome. A structured method of analysing the algorithm is developed and conducted. The analysis method consists of six test scenarios. Scripts are created, which execute the algorithm using various parameter settings. Three nucleotide sequences are applied; a real sequence extracted from the human genome and two random sequences, generated using different base probabilities. Usability and accuracy are inv
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22

Von, Kirchbach Johann Carlo. "In silico analysis of RNA signals and evolutionary constraints in influenza A virus." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609825.

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23

Simila, Henry Allan. "Recombinant production and in silico analysis of the Androgen receptor ligand binding domain." Thesis, Queensland University of Technology, 2006. https://eprints.qut.edu.au/16349/1/Henry_Simila_Thesis.pdf.

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The androgen receptor (AR) fulfils important roles for both sexes. By mediating the biological function of androgens, the AR has remained the target for endocrine therapies treating prostate cancer. The AR also determines the effectiveness of medroxyprogesterone acetate (MPA) in treating AR positive breast cancer. Every man will be affected by prostate cancer if he lives long enough. Prostate cancer continues to be a leading cause of death for males despite research into this cancer covering more than 60 years since Huggins' seminal 1941 study showing that androgens play a key role in this
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Simila, Henry Allan. "Recombinant production and in silico analysis of the Androgen receptor ligand binding domain." Queensland University of Technology, 2006. http://eprints.qut.edu.au/16349/.

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The androgen receptor (AR) fulfils important roles for both sexes. By mediating the biological function of androgens, the AR has remained the target for endocrine therapies treating prostate cancer. The AR also determines the effectiveness of medroxyprogesterone acetate (MPA) in treating AR positive breast cancer. Every man will be affected by prostate cancer if he lives long enough. Prostate cancer continues to be a leading cause of death for males despite research into this cancer covering more than 60 years since Huggins' seminal 1941 study showing that androgens play a key role in this
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25

Sörman, Paulsson Elsa. "Evaluation of In-Silico Labeling for Live Cell Imaging." Thesis, Umeå universitet, Institutionen för fysik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180590.

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Today new drugs are tested on cell cultures in wells to minimize time, cost, andanimal testing. The cells are studied using microscopy in different ways and fluorescentprobes are used to study finer details than the light microscopy can observe.This is an invasive method, so instead of molecular analysis, imaging can be used.In this project, phase-contrast microscopy images of cells together with fluorescentmicroscopy images were used. We use Machine Learning to predict the fluorescentimages from the light microscopy images using a strategy called In-Silico Labeling.A Convolutional Neural Netw
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26

Lawton, Phillip. "In silico and functional analysis of genomic aberrations associated with pancreatic and ovarian cancers." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/49207.

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High grade serous (HGS) ovarian cancer and pancreatic ductal adenocarcinoma (PDAC) are poor prognosis neoplasms that are characterised by high levels of genomic instability, DNA damage repair (DDR) defects, and drug resistance which ultimately results in poor survival rates. This study aims to use markers of genomic instability, in the form of copy number variations (CNVs) and gene expression changes, to identify DDR gene aberrations which contribute to poor patient prognosis and drug resistance in HGS ovarian cancer and PDAC, and which may be exploited for therapeutic benefit. Bioinformatic a
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27

Abdel-Glil, Mostafa Youssef [Verfasser]. "In silico genome analysis and molecular typing of Clostridium perfringens / Mostafa Y. Abdel-Glil." Berlin : Freie Universität Berlin, 2020. http://nbn-resolving.de/urn:nbn:de:kobv:188-refubium-26585-2.

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28

Amusengeri, Arnold. "In silico analysis of plasmodium falciparum Hsp70-x for potential binding sites and hits." Thesis, Rhodes University, 2017. http://hdl.handle.net/10962/59136.

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29

Lenive, Oleg. "The role of extrinsic noise in biomolecular information processing systems : an in silico analysis." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/31575.

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The intrinsic stochasticity of biomolecular systems is a well studied phe- nomenon. Less attention has been paied to other sources of variability, so called extrinsic noise. While the precise definition of extrinsic noise de- pends on the system in question, it affects all cells and its significance has been demonstrated experimentally. Information theory provides a rigorous mathematical framework for quan- tifying both the amount of information available to a signalling system and its ability to transmit this information. Intracellular signal transduction re- mains a relatively unexplored fro
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Abdel-Glil, Mostafa Y. [Verfasser]. "In silico genome analysis and molecular typing of Clostridium perfringens / Mostafa Y. Abdel-Glil." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1204432899/34.

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31

SARTORI, ELISA. "Parametric connectivity analysis in time and frequency domain from in silico and EEG data." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3426641.

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In this decade, establishing structure-function relationships in human brain has become one of the most influential concepts in modern cognitive neuroscience since interactions among cerebral components are fundamental to explain cortical activities ([1]; [2]; [3]). In literature such relationships have been defined in terms of structural, functional and effective connectivity. This distinction, mainly focused on the theoretic concept, is also related to the different measurement instruments and analytical tools used for acquiring and processing the data. The structural connectivity refers to
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Saturnino, Christine Facco. "Estudo in silico de derivados do G-CSF humano como antibacterianos." reponame:Repositório Institucional da UFES, 2013. http://repositorio.ufes.br/handle/10/1867.

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Submitted by Morgana Andrade (morgana.andrade@ufes.br) on 2016-04-08T20:24:35Z No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) tese_6676_Dissertao_Christine Facco_2013.pdf: 1315436 bytes, checksum: 39ff1bc59d15b9b7a17e711efee2949b (MD5)<br>Approved for entry into archive by Patricia Barros (patricia.barros@ufes.br) on 2016-05-13T14:04:33Z (GMT) No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) tese_6676_Dissertao_Christine Facco_2013.pdf: 1315436 bytes, checksum: 39ff1bc59d15b9b7a17e711efee2949b
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Chan, Gerard. "Feature analysis and in silico prediction of lower solubility proteins in three eukaryotic model systems." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52711.

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Regulation of protein solubility, or the ability of proteins to remain soluble within the cell, is an important part of protein homeostasis. This is highlighted with the disruption of protein homeostasis and dysregulation of solubility being associated with various neurodegenerative diseases. Using quantitative mass spectrometry and computational analyses, we identify low solubility proteins under unstressed conditions in three eukaryotic model systems: yeast cells, human neuroblastoma cells, and mouse brain tissue. Using an internal reference, we account for protein abundance, and allow for t
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Lee, Adam. "The in silico identification and analysis of ancient and recent endogenous retroviruses in mammalian genomes." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/39972.

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Recent advances in DNA sequencing technologies have led to a vast plethora of vertebrate genomes being made available for bioinformatic analysis and investigation. This has presented retrovirologists with many new opportunities to study endogenous retroviruses (ERVs) - selfish genetic element (SGEs) endogenised within the genomic DNA of their hosts. Many of these ERVs exist as molecular fossils of past germline infections by their exogenous counterparts, representing approximately 8-10% of mammalian genomes. While the majority are thought to be inactive today, one particular retroviral group -
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35

Clitheroe, Crystal-Leigh. "In-silico analysis of Plasmodium falciparum Hop protein and its interactions with Hsp70 and Hsp90." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/d1003819.

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A lessor understood co-chaperone, the Hsp70/Hsp90 organising protein (Hop), has been found to play an important role in modulating the activity and co-interaction of two essential chaperones; Hsp90 and Hsp70. The best understood aspects of Hop so far indicate that residues in the concave surfaces of the three tetratricopeptide repeat (TPR) domains in the protein bind selectively to the C-terminal motifs of Hsp70 and Hsp90. Recent research suggests that P. falciparum Hop (PfHop), PfHsp90 and PfHsp70 do interact and form complex in the P. falciparum trophozooite and are overexpressed in this inf
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36

Jean, Géraldine. "In silico methods for genome rearrangement analysis : from identification of common markers to ancestral reconstruction." Thesis, Bordeaux 1, 2008. http://www.theses.fr/2008BOR13704/document.

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L'augmentation du nombre de génomes totalement séquencés rend de plus en plus efficace l'étude des mécanismes évolutifs à partir de la comparaison de génomes contemporains. L'un des principaux problèmes réside dans la reconstruction d'architectures de génomes ancestraux plausibles afin d'apporter des hypothèses à la fois sur l'histoire des génomes existants et sur les mécanismes de leur formation. Toutes les méthodes de reconstruction ancestrale ne convergent pas nécessairement vers les mêmes résultats mais sont toutes basées sur les trois mêmes étapes : l'identification des marqueurs communs
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37

AMARA, FLAVIO. "BYPASS OF UV-INDUCED DNA LESIONS IN SACCHAROMYCES CEREVISIAE: EXPERIMENTAL ANALYSIS AND "IN SILICO" MODELING." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/214278.

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My research activity has been supported by the bioinformatic platform of the Fondazione Cariplo NOBEL Project named “Understanding DNA damage checkpoint and repair”. The aim of this platform was to investigate the molecular mechanisms involved in the DNA Damage Response (DDR), through a Systems Biology approach. Among the DDR pathways, the focus of my research was the DNA Damage Tolerance (DDT) pathway called Post-Replication Repair (PRR) using Saccharomyces cerevisiae cells as a model system. This pathway leads to the bypass of UV-induced DNA lesions through a mechanism, which is poorly cha
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Roussel, Michaël. "Séquençage du génome du parasite intestinal Blastocystis sp. (ST7) : vers une meilleure compréhension des capacités métaboliques d'organites apparentés aux mitochondries chez ce microorganisme anaérobie." Thesis, Clermont-Ferrand 2, 2011. http://www.theses.fr/2011CLF22164/document.

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Blastocystis sp., est un straménopile parasite anaérobie fréquemment rencontré dans le tractus gastro-intestinal de l’homme et de divers animaux. Ce microorganisme, parfois responsable de désordres digestifs aigus, pourrait conduire à des troubles fonctionnels intestinaux tels que le syndrome de l’intestin irritable (IBS). Le génome de Blastocystis sp., qui a fait l'objet d'un projet de séquençage en collaboration avec le Génoscope d’Evry, nous a permis de caractériser le plus petit génome de straménopile séquencé à ce jour (18,8 Mpb), avec une capacité codante de 6020 gènes. L’acquisition de
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Wang, Tingzhang. "Make inferences about bacterial gene functions with the concept of neighborhood in silico." Thesis, Evry-Val d'Essonne, 2010. http://www.theses.fr/2010EVRY0036/document.

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Avec l'accroissement du nombre de génomes séquencés, l'organisation de ces données brutes et des données dérivées, l'extraction de l'information et des connaissances associées défie l'imagination. La notion de voisinage a été d'abord été introduite pour l'organisation des données dans des bases de données relationnelles. Pour extraire des informations pertinentes à partir de données massives, différents types de voisinages ont été étudiés ici. Tout d'abord, avec l'analysedes correspondances (CA) et en utilisant le regroupement supervisé ("model clustering" MBC), la proximité mutuelle des éléme
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40

Oliveira, AntÃnio Edson Rocha. "Perfil de expressÃo e anÃlise filogenÃtica dos genes da proteÃna desacopladora mitocondrial durante o desenvolvimento e estresse em soja [Glycine max (L.) Merr.]." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=14737.

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CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior<br>Diversos estudos tÃm evidenciado que a principal funÃÃo da proteÃna desacopladora mitocondrial de plantas (pUCP) està relacionada a regulaÃÃo de espÃcies reativas de oxigÃnio (EROs). AnÃlises in silico sugerem a existÃncia de famÃlias multigÃnicas para a codificaÃÃo de pUCPs, porÃm novos estudos ainda sÃo necessÃrios para estabelecer o perfil de expressÃo gÃnica das pUCPs, assim como a quantidade de genes em cada espÃcie e suas relaÃÃes filogenÃticas. O presente trabalho teve como objetivo caracterizar, analisar filogeneticamente e
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Souza, Valeska Daliane Souto de. "An?lise de cDNAs identificados em bibliotecas substrativas de cDNA para flora??o de variedades de cana-de-a??car cultivadas no Rio Grande do Norte(RN): fator de transi??o NAC, Calmodulina e Fosfatidiltransferase." Universidade Federal do Rio Grande do Norte, 2011. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13077.

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Made available in DSpace on 2014-12-17T14:10:25Z (GMT). No. of bitstreams: 1 ValeskaDSS_DISSERT.pdf: 2384968 bytes, checksum: cf4765fd0b42fd627fcb0ce0d604be1e (MD5) Previous issue date: 2011-10-18<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>The flowering is a physiological process that it is vital for plants. This physiological process has been well studied in the plant model Arabidopsis, but in sugarcane this process is not well known. The transition of the shoot apical meristem from vegetative to flowering is a critical factor for plant development. At Brazil northeas
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Milica, Karadžić. "Хроматографска, микробиолошка и in silico анализа стероидних једињења од потенцијалног биомедицинског значаја". Phd thesis, Univerzitet u Novom Sadu, Tehnološki fakultet Novi Sad, 2017. http://www.cris.uns.ac.rs/record.jsf?recordId=104606&source=NDLTD&language=en.

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Испитивано је хроматографско понашање (хроматографска липофилност) 29 стероидних једињења (триазола и тетразола, толуенсулфонилхидразида, диона, нитрила и динитрила) од потенцијалног биомедицинског значаја, испитивано је помоћу течне хроматографије високих перформанси на обрнутим фазама, применом две стационарне и две мобилне фазе. Липофилност, изражена преко ретенционог параметра logk, моделована је QSRR приступом. Формирани линеарни и нелинеарни модели омогућили су испитивање односа између ретенционих параметара и in silico молекулских дескриптора, који су израчунати на основу структуре испи
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43

Jun, Min Medical Sciences Faculty of Medicine UNSW. "Analysis of human cytomegalovirus susceptibility to novel antiviral agents." Publisher:University of New South Wales. Medical Sciences, 2008. http://handle.unsw.edu.au/1959.4/41443.

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Human cytomegalovirus (CMV) is a significant infectious agent causing disease in immunocompromised HIV-infected patients, transplant recipients, and neonates. The current antiviral therapeutic strategy against CMV is limited in its utility due to the inherent toxicity and lack of bioavailability of currently available anti-CMV agents, ganciclovir (GCV), cidofovir (CDV), and foscarnet (FOS). The development of the prodrug of GCV, valganciclovir (val-GCV), has vastly improved the bioavailability profile of GCV. However, val-GCV demonstrates limited effectiveness against tissue-invasive CMV dise
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44

LI, YUCHEN. "MICROALGAE PEPTIDES IN CARDIOVASCULAR DISEASE PREVENTION: STRUCTURE ELUCIDATION,BIOACTIVITY INVESTIGATION,AND IN SILICO MOLECULAR MODELING ANALYSIS." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/850789.

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Bioactive food-derived peptides have been increasingly studied and the multiple health benefits they provide have been acknowledged. Since the most investigated sources of bioactive peptides are eggs, meat, fish, soybean, wheat, milk, and their derivatives or byproducts. More recently, some attention is being paid to microalgae, a promising unconventional protein source. On this basis, the PhD thesis was focused on the evaluation of the potential of microalgae to generate peptides with cardiovascular-promoting effects, especially hypotensive and antidiabetic activities, by targeting two therap
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Medeiros, Cássio Ilan Soares. "Atividades Antifúngica e Toxicológica In Silico dos Enantiômeros (R)-(+)- e (S)-(-)-citronelal." Universidade Federal da Paraíba, 2016. http://tede.biblioteca.ufpb.br:8080/handle/tede/8809.

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Submitted by Cristhiane Guerra (cristhiane.guerra@gmail.com) on 2017-02-01T13:46:41Z No. of bitstreams: 1 arquivototal.pdf: 2056832 bytes, checksum: dd1f04e5a02bdef6bb3220514f057563 (MD5)<br>Made available in DSpace on 2017-02-01T13:46:41Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 2056832 bytes, checksum: dd1f04e5a02bdef6bb3220514f057563 (MD5) Previous issue date: 2016-10-25<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>The incidence of vulvovaginal fungal infections has increased dramatically over the last decades, therefore being the second most common cause
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Russell, Steven Arthur. "Machine learning and in silico modeling for improved identification of peptides from shotgun proteomic Ms/Ms spectra /." Connect to full text via ProQuest. IP filtered, 2005.

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Thesis (Ph.D. in Bioinformatics) -- University of Colorado, 2005.<br>Typescript. Includes bibliographical references (leaves 116-124). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;
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Boeck, Anna Carolina, and Juliano Tomazzoni Boldo. "PA³P: uma nova ferramenta para determinação in silico da alergenicidade e antigenicidade de proteínas." Universidade Federal do Pampa, 2016. http://dspace.unipampa.edu.br:8080/xmlui/handle/riu/1616.

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Submitted by Ana Damasceno (ana.damasceno@unipampa.edu.br) on 2017-06-07T21:02:40Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) PA³P uma nova ferramenta para determinação in silico da alergenicidade e antigenicidade de proteínas.pdf: 4093415 bytes, checksum: 0bc76850b4fffd6e3c97f8f6a339dc0b (MD5)<br>Made available in DSpace on 2017-06-07T21:02:40Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) PA³P uma nova ferramenta para determinação in silico da alergenicidade e antigenicidade de
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48

MICOZZI, DANIELA. "Exploiting Structural Analysis, in Silico Screening and functional variants characterization to identify novel inhibitors of cytidine deaminase." Doctoral thesis, Università degli Studi di Camerino, 2012. http://hdl.handle.net/11581/401792.

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This thesis work, combining a virtual screening study for cytidine deaminase ligands with a study on the effect that genetic polymorphisms have on the enzyme functionality provide a useful base to: a) understand the mechanism of nucleoside recognition by CDA and identify novel effective inhibitors; and b) study the different properties of said inhibitors toward three distinct naturally occurring CDA variants (K27, Q27 and T70). Ultimately, this may assist the future design of novel CDA inhibitors or antitumor drugs not susceptible to deamination, with the aim to get more effective personalized
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SINGH, REETIKA. "COMPARATIVE ANALYSIS OF DIFFERENT CURCUMIN ANALOGUES TO INHIBIT TLR4 EXPRESSION IN BREAST CANCER- AN IN-SILICO STUDY." Thesis, DELHI TECHNOLOGICAL UNIVERSITY, 2021. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18459.

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Chronic inflammation is closely related to the emergence of a number of cancers, including Breast cancer. Inflammation causes damage to the cell’s DNA which leads to its abnormal growth and formation of tumor mass. One of the most commonly known receptor responsible for inflammatory reactions is Toll-like receptor 4 (TLR4). It is activated majorly by bacterial LPS. Its activation further activates Cyclooxygenase enzyme that catalyzes the conversion of arachidonic acid into prostaglandins that lead to inflammation-like conditions. COX2 has also been correlated to the promotion of tumor g
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Karolski, Bruno. "Metagenômica comparativa e perfil metabólico in silico de solos no município de Cubatão, SP." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-05112013-111556/.

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Cubatão, o maior pólo industrial da américa latina também já foi uma das cidades mais poluídas do mundo. Os 30 anos de intensa atividade industrial vêm pressionando o meio ambiente com substâncias tóxicas e afetando gravemente a saúde da população. Dentre as substâncias contaminantes mais importantes da região estão os derivados de petróleo como o benzeno, tolueno, etilbenzeno e xilenos. Conhecidos como BTEX, eles são produzidos e utilizados em larga escala e a contaminação ocorre frequentemente através de vazamentos. Nos solos, devido à sua solubilidade em água, essas substâncias podem se esp
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