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Journal articles on the topic 'Silicosi'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Gupta, Rakesh C., Mayank Vats, Pramod Dadhich, Neeraj Gupta, and Mukesh Taylor. "Steroid Pulse Therapy in Silicosi." Chest 124, no. 4 (2003): 215S. http://dx.doi.org/10.1378/chest.124.4_meetingabstracts.215s-a.

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2

Jin, Fuyu, Yaqian Li, Xiaojing Wang, et al. "Effect of Sex Differences in Silicotic Mice." International Journal of Molecular Sciences 23, no. 22 (2022): 14203. http://dx.doi.org/10.3390/ijms232214203.

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Mechanisms of silicosis, caused by the inhalation of silica are still unclear, and the effect of sex on silicosis has rarely been reported. The purpose of this study was to investigate whether sex affects the silicotic lesions and the progressive fibrotic responses in silicosis. Our study showed that sex had no significant effect on the area of silicon nodules and the collagen deposition after a one-time bronchial perfusion of silica. Immunohistochemical staining showed that CD68 and the transforming growth factor-β1 (TGF-β1) were positive in male and female silicotic mice. In addition, the we

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Chien, Hsiu-Ping, Tao-Ping Lin, Hsiao-Ling Chen, and Thomas W. Huang. "Right Middle Lobe Atelectasis Associated With Endobronchial Silicotic Lesions." Archives of Pathology & Laboratory Medicine 124, no. 11 (2000): 1619–22. http://dx.doi.org/10.5858/2000-124-1619-rmlaaw.

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Abstract Background.—In a period of 18 months, we have encountered 4 cases of right middle lobe atelectasis associated with endobronchial silicotic lesions of right middle lobe bronchi. All patients had occupational exposure to mineral dusts (3 coal miners and 1 sand blaster) for months to decades. Methods.—The nature of the endobronchial silicotic lesions that caused the bronchial obstruction has been confirmed by endobronchial biopsies and energy-dispersive spectrometry of the lesions. Extrinsic compression has been excluded by careful radiographic and computed tomographic image analysis. Re

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Geng, Fei, Lan Zhao, Yuhao Cai та ін. "Quercetin Alleviates Pulmonary Fibrosis in Silicotic Mice by Inhibiting Macrophage Transition and TGF-β-Smad2/3 Pathway". Current Issues in Molecular Biology 45, № 4 (2023): 3087–101. http://dx.doi.org/10.3390/cimb45040202.

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Silicosis is a pulmonary disease caused by the inhalation of silica. There is a lack of early and effective prevention, diagnosis, and treatment methods, and addressing silicotic fibrosis is crucial. Quercetin, a flavonoid with anti-carcinogenic, anti-inflammatory, and antiviral properties, is known to have a suppressive effect on fibrosis. The present study aimed to determine the therapeutic effect of quercetin on silicotic mice and macrophage polarity. We found that quercetin suppressed silicosis in mice. It was observed that SiO2 activated macrophage polarity and the macrophage-to-myofibrob

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Ferrante, Pierpaolo. "Asbestosis and silicosis hospitalizations in Italy (2001–2015): results from the National Hospital Discharge Registry." European Journal of Public Health 29, no. 5 (2019): 876–82. http://dx.doi.org/10.1093/eurpub/ckz003.

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Abstract Background This work is aimed at evaluating the quality of Italian hospitalizations data about asbestosis and silicosis, assessing the impact of these diseases on the national health system and providing advice related to public health. Methods Italian hospital discharge data (2001–15) with diagnosis of asbestosis or silicosis were analysed by the multiple correspondence analysis and diseases epidemics were evaluated through hospitalization rates. Results Hospitalizations were concentrated in the northwestern area, referred mainly to males and oldest people, the most treated tumors we

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Mao, Na, Yuhang Fan, Wenjing Liu, et al. "Oxamate Attenuates Glycolysis and ER Stress in Silicotic Mice." International Journal of Molecular Sciences 23, no. 6 (2022): 3013. http://dx.doi.org/10.3390/ijms23063013.

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Glycolysis and ER stress have been considered important drivers of pulmonary fibrosis. However, it is not clear whether glycolysis and ER stress are interconnected and if those interconnections regulate the development of pulmonary fibrosis. Our previous studies found that the expression of LDHA, a key enzyme involved in glycolysis, was increased in silica-induced macrophages and silicotic models, and it was closely related to silicosis fibrosis by participating in inflammatory response. However, whether pharmacological inhibition of LDHA is beneficial to the amelioration of silicosis fibrosis

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Li, Yaqian, Wenchen Cai, Fuyu Jin та ін. "Thalidomide Alleviates Pulmonary Fibrosis Induced by Silica in Mice by Inhibiting ER Stress and the TLR4-NF-κB Pathway". International Journal of Molecular Sciences 23, № 10 (2022): 5656. http://dx.doi.org/10.3390/ijms23105656.

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Silicosis is the most prevalent occupational disease in China. It is a form of pulmonary fibrosis caused by the inhalation of silicon particles. As there is no cure for the potentially lethal and progressive condition, the treatment of silicotic fibrosis is an important and difficult problem to address. Thalidomide, a drug with anti-inflammatory and immunoregulatory properties, has been reported to have lung-protective effects. The purpose of this study was to observe the therapeutic effect of thalidomide on silicotic mice and to determine the protective mechanism. By using silicotic mice mode

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8

Carreño Hernández, M. Cruz, Sara Garrido Paniagua, María Colomés Iess, and Mehdi Guemra. "Accelerated silicosis with bone marrow, hepatic and splenic involvement in a patient with lung transplantation." BMJ Case Reports 12, no. 12 (2019): e230781. http://dx.doi.org/10.1136/bcr-2019-230781.

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Chronic silicosis is an entity widely described in literature. However, other types such as accelerated, acute, complicated and extrapulmonary silicosis are little documented. We present a case of accelerated extrapulmonary silicosis in a lung transplant patient in whom the diagnosis of systemic silicosis was made incidental to non-respiratory complications that occurred during follow-up. The appearance of cytopenia and liver failure led to diagnostic tests that documented the presence of silicotic granulomas in those locations. Taking into account the intensity, time of exposure, onset and de

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9

Yang, Shuyuan, Chi Kuen Chan, Maggie Haitian Wang, Chi Chiu Leung, Lai Bun Tai, and Lap Ah Tse. "Association of smoking cessation with airflow obstruction in workers with silicosis: A cohort study." PLOS ONE 19, no. 5 (2024): e0303743. http://dx.doi.org/10.1371/journal.pone.0303743.

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Background Studies in general population reported a positive association between tobacco smoking and airflow obstruction (AFO), a hallmark of chronic obstructive pulmonary disease (COPD). However, this attempt was less addressed in silica dust-exposed workers. Methods This retrospective cohort study consisted of 4481 silicotic workers attending the Pneumoconiosis Clinic during 1981–2019. The lifelong work history and smoking habits of these workers were extracted from medical records. Spirometry was carried out at the diagnosis of silicosis (n = 4177) and reperformed after an average of 9.4 ye

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10

Mao, Na, Honghao Yang, Jie Yin, et al. "Glycolytic Reprogramming in Silica-Induced Lung Macrophages and Silicosis Reversed by Ac-SDKP Treatment." International Journal of Molecular Sciences 22, no. 18 (2021): 10063. http://dx.doi.org/10.3390/ijms221810063.

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Glycolytic reprogramming is an important metabolic feature in the development of pulmonary fibrosis. However, the specific mechanism of glycolysis in silicosis is still not clear. In this study, silicotic models and silica-induced macrophage were used to elucidate the mechanism of glycolysis induced by silica. Expression levels of the key enzymes in glycolysis and macrophage activation indicators were analyzed by Western blot, qRT-PCR, IHC, and IF analyses, and by using a lactate assay kit. We found that silica promotes the expression of the key glycolysis enzymes HK2, PKM2, LDHA, and macropha

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11

Franco Júnior, Rogério de Moraes, Jéssica Perira Nunes, Gheysa Chisper Cunha Resende, et al. "Estratégias de saúde do trabalhador para a promoção de saúde e prevenção de silicoses." CONTRIBUCIONES A LAS CIENCIAS SOCIALES 18, no. 5 (2025): e17989. https://doi.org/10.55905/revconv.18n.5-256.

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A silicose é uma pneumoconiose ocupacional causada pela inalação de sílica cristalina. Constitui um desafio de saúde pública no Brasil, especialmente em setores como mineração, construção civil e lapidação de pedras. O objetivo deste estudo foi analisar estratégias de Saúde do Trabalhador para prevenção da doença. A pesquisa tratou-se de uma revisão narrativa de literatura, ancorada na questão: o que a literatura científica tem abordado sobre as estratégias em Saúde do Trabalhador para reduzir as taxas de silicoses nos ambientes laborais? A busca com as palavras-chave, foi realizada em abril d

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Li, Tian, Xin-yu Yang, Ding-jie Xu, et al. "OC-STAMP Overexpression Drives Lung Alveolar Epithelial Cell Type II Senescence in Silicosis." Oxidative Medicine and Cellular Longevity 2021 (August 14, 2021): 1–11. http://dx.doi.org/10.1155/2021/4158495.

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Cellular senescence has been considered an important driver of many chronic lung diseases. However, the specific mechanism of cellular senescence in silicosis is still unknown. In the present study, silicotic rats and osteoclast stimulatory transmembrane protein (Ocstamp) overexpression of MLE-12 cells were used to explore the mechanism of OC-STAMP in cellular senescence in alveolar epithelial cell type II (AEC2). We found an increasing level of OC-STAMP in AEC2 of silicotic rats. Overexpression of Ocstamp in MLE-12 cells promoted epithelial-mesenchymal transition (EMT), endoplasmic reticulum

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Palomar-Llatas, F., J. Bonías-López, J. Zamora-Ortiz, et al. "Tratamiento no invasivo de cicatrices con apósitos de silicona en placa. Estudio observacional." Enfermería Dermatológica 12, no. 35 (2018): 35–39. https://doi.org/10.5281/zenodo.2550370.

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<strong>RESUMEN: Objetivo:</strong> Determinar mediante observación la mejoría y evolución de las cicatrices queloides tratadas con apósitos de lámina de silicona. <strong>Metodología:</strong> Estudio observacional descripti-vo transversal. Observación de cicatrices agudas y neoformadas (queloides) con un mínimo dos años de evolución en tratamiento con cura tradicional. Aplicación de un tratamiento protocolizado de apósito de lámina de silicona y, seguimiento seriado durante tres meses o cicatrizaci&oac

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14

Zhu, Ying, Jingxin Yao, Yuxia Duan, et al. "Protein Expression Profile in Rat Silicosis Model Reveals Upregulation of PTPN2 and Its Inhibitory Effect on Epithelial-Mesenchymal Transition by Dephosphorylation of STAT3." International Journal of Molecular Sciences 21, no. 4 (2020): 1189. http://dx.doi.org/10.3390/ijms21041189.

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Silicosis is a chronic occupational lung disease caused by long-term inhalation of crystalline silica particulates. We created a rat model that closely approximates the exposure and development of silicosis in humans. Isobaric tags for relative and absolute quantitation (iTRAQ) technologies we used to identify proteins differentially expressed in activated rat lung tissue. We constructed three lentiviral knockdown vectors and an overexpression vector for the protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene to achieve stable long-term expression. A total of 471 proteins were differ

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Singh, Dharmendra, Samit Kumar Carr, Bidisa Sarkar, Syed Irfan Ali, and Kamalesh Sarkar. "A cluster onset of acute and accelerated silicosis cases in workers of ramming mass industries in Jharkhand, Eastern India." Journal of Family Medicine and Primary Care 12, no. 8 (2023): 1654–58. http://dx.doi.org/10.4103/jfmpc.jfmpc_2518_22.

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Introduction and Methodology: A cross-sectional study was conducted among workers of ramming mass industries in the East Singhbhum district of Jharkhand, eastern India. Workers had occupational exposure to respirable crystalline silica dust of varied duration between 1 and 6 years. A total of 122 subjects participated in it. Relevant epidemiological information was collected from them. All were x-rayed using 300 mA radiation for the detection of the presence of silicotic opacities if any as described by the International Labour Organisation (ILO) for the detection of silicosis. Results: The st

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Salih, Mohsin, Tarake Aljarod, Mohamed Ayan, Melnick Jeffrey, and Bobby H. Shah. "Pulmonary Silicosis Presents with Pleural Effusion." Case Reports in Medicine 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/543070.

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Silica and silicate mineral dust inhalation can cause a variety of histopathological changes in the lungs and pleura. These include pulmonary silicotic nodules, interstitial infiltrate, fibrosis, and pleural thickening. Pleural effusion is an extremely rare presentation of silicosis. To our best knowledge, there have been only 2 cases of silicosis with pleural effusion reported in medical literature. Herein, we describe a case of a 77-year-old male with almost 50 years’ history of occupational silica exposure. He presented with a 4-week history of exertional shortness of breath. He is a lifeti

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Bayma, Julliane Feitosa, Thiffany Vitória Soares da Silva Santos, João Victor Menezes Do Nascimento, et al. "A influência de diferentes espessuras de matrizes de silicona na microdureza de resinas injetáveis." Brazilian Journal of Health Review 6, no. 3 (2023): 8557–68. http://dx.doi.org/10.34119/bjhrv6n3-015.

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As resinas de baixa viscosidade na técnica injetável ganharam espaço na Odontologia por serem um material mais econômico e conservador quando comparadas com os laminados cerâmicos e com técnicas que dispõem de maior tempo clínico. A técnica envolve enceramento dentário e confecção de uma matriz de silicone transparente, onde foi injetada a resina Beautiful Flow Plus (Shofu) F03 na cor A2. A silicona deve possuir translucidez para guiar o operador na quantidade de resina a ser injetada. A presente pesquisa tem a finalidade de testar a microdureza superficial da resina fluida depois de fotopolim

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Chopra, Christina Shree, Patricia Thistlethwaite, Fernando Herrera, and Ahmed Suliman. "Iatrogenic intrathoracic encapsulated siliconoma from a ruptured breast implant." BMJ Case Reports 14, no. 9 (2021): e243870. http://dx.doi.org/10.1136/bcr-2021-243870.

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Our patient was a 57-year-old woman with a history of bilateral retropectoral silicone breast augmentation and axillary hyperhidrosis who underwent a bilateral thoracic sympathectomy via video-assisted thoracoscopic surgery by a surgeon at an outside hospital approximately 20 years ago. The left side required an open thoracotomy. Shortly after the surgery, she developed a left-sided Baker 4 capsular contracture and the left implant was noted to be ruptured. Both implants were exchanged. Several years later the patient began to experience progressive fatigue. Work-up revealed a left lung nodule

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Garn, Holger, Anke Friedetzky, Andrea Kirchner, Ruth Jäger та Diethard Gemsa. "Experimental silicosis: a shift to a preferential IFN-γ-based Th1 response in thoracic lymph nodes". American Journal of Physiology-Lung Cellular and Molecular Physiology 278, № 6 (2000): L1221—L1230. http://dx.doi.org/10.1152/ajplung.2000.278.6.l1221.

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In chronic silicosis, mechanisms leading to lymphocyte activation are still poorly understood, although it is well known that not only the lung but also the draining lymph nodes are affected. In the present study, we investigated T-cell activation by analysis of cytokine expression in the enlarged thoracic lymph nodes of rats 2 mo after an 8-day silica aerosol exposure. In the case of helper T cell (Th) type 1 cytokines, we found a significant increase in interferon (IFN)-γ mRNA expression, whereas interleukin (IL)-2 expression remained unchanged. In contrast, gene transcription for the Th2-ty

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Cassidy, SL, A. Hale, DC Buss, and PA Routledge. "In vitro drug adsorption to charcoal, silicas, acrylate copolymer and silicone oil with charcoal and with acrylate copolymer." Human & Experimental Toxicology 16, no. 1 (1997): 25–27. http://dx.doi.org/10.1177/0960327197016001051.

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1 The relative binding constants of four drugs to charcoal, silicone oil silicas and acrylate copolymers was studied using an in-vitro binding technique. 2 The maximum adsorption capacity (K2) was chosen as a measure of the degree of binding and calculated by fitting to the Langmuir equation. 3 Charcoal alone was shown to be the most effective of the adsorbents chosen. The possible use of silicone oils as an adsorbent delivery vehicle in treatment of overdose is discussed.

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Beshir, Safia, Hisham Aziz, Weam Shaheen, and Eman Eltahlawy. "Serum Levels of Copper, Ceruloplasmin and Angiotensin Converting Enzyme among Silicotic and Non-Silicotic Workers." Open Access Macedonian Journal of Medical Sciences 3, no. 3 (2015): 467–73. http://dx.doi.org/10.3889/oamjms.2015.065.

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BACKGROUND: Silicosis is the most frequently occurring pneumoconiosis.AIM: Measurement of serum levels of Angiotensin converting enzyme (ACE), Copper (Cu) and Ceruloplasmin (Cp) in cement workers occupationally exposed to silica dust as biomarkers of exposure rather than biomarkers of effect for silicosis.METHODS: Plain chest X-ray & pulmonary functions were done for 30 silicotic and 42 non-silicotic workers and 42 controls. CT scan was done for the exposed groups. Serum levels of Cu, Cp and ACE were estimated.RESULTS: The results showed a higher significant difference between the exposed

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Torres, Anaëlle, Véronique Collin-Faure, Daphna Fenel, Jacques-Aurélien Sergent, and Thierry Rabilloud. "About the Transient Effects of Synthetic Amorphous Silica: An In Vitro Study on Macrophages." International Journal of Molecular Sciences 24, no. 1 (2022): 220. http://dx.doi.org/10.3390/ijms24010220.

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Silica (either crystalline or amorphous) is widely used for different applications and its toxicological assessment depends on its characteristics and intended use. As sustained inflammation induced by crystalline silica is at the root of silicosis, investigating the inflammatory effects induced by amorphous silicas and their persistence is needed. For the development of new grades of synthetic amorphous silicas, it is also desirable to be able to understand better the factors underlying potential adverse effects. Therefore, we used an optimized in vitro macrophage system to investigate the ef

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Komai, Mao, Karin Mihira, Akinori Shimada, et al. "Pathological Study on Epithelial-Mesenchymal Transition in Silicotic Lung Lesions in Rat." Veterinary Sciences 6, no. 3 (2019): 70. http://dx.doi.org/10.3390/vetsci6030070.

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Silicosis, caused by the inhalation of crystalline silicon dioxide or silica, is one of the most severe occupational diseases. Persistent inflammation and progressive massive pulmonary fibrosis are the most common histological changes caused by silicosis. Association of epithelial-mesenchymal transition (EMT) of hyperplastic type II epithelial cells with the fibrotic events of pulmonary fibrosis has been suggested in in vitro silica-exposed cultured cell models, patients with idiopathic pulmonary fibrosis, and bleomycin-induced experimental models. Histological features of EMT, however, are no

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Adamcakova, Jana, Sona Balentova, Romana Barosova, et al. "Effects of Green Tea Polyphenol Epigallocatechin-3-Gallate on Markers of Inflammation and Fibrosis in a Rat Model of Pulmonary Silicosis." International Journal of Molecular Sciences 24, no. 3 (2023): 1857. http://dx.doi.org/10.3390/ijms24031857.

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Inhalation of silica particles causes inflammatory changes leading to fibrotizing silicosis. Considering a lack of effective therapy, and a growing information on the wide actions of green tea polyphenols, particularly epigallocatechin-3-gallate (EGCG), the aim of this study was to evaluate the early effects of EGCG on markers of inflammation and lung fibrosis in silicotic rats. The silicosis model was induced by a single transoral intratracheal instillation of silica (50 mg/mL/animal), while controls received an equivalent volume of saline. The treatment with intraperitoneal EGCG (20 mg/kg, o

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Misson, Pierre, Frank Brombacher, Monique Delos, Dominique Lison, and Francois Huaux. "Type 2 immune response associated with silicosis is not instrumental in the development of the disease." American Journal of Physiology-Lung Cellular and Molecular Physiology 292, no. 1 (2007): L107—L113. http://dx.doi.org/10.1152/ajplung.00503.2005.

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It has been proposed that the development of lung fibrosis is associated with a T helper type 2 response, mainly characterized by IL-4 and IL-13 production. We investigated the potential role of type 2 immune polarization in the silicotic process and examined the pulmonary response to silica particles in mice genetically deficient for IL-4. We found that IL-4−/− mice were not protected against the development of silicosis, suggesting that IL-4 is not essential for the development of this fibrotic disease. By evaluating the intensity of silica-induced lung fibrosis in mice deficient for IL-4 re

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Kim, You Mie, Young Jin Kim, and Soo Young Lee. "Identification of Cross-linked 46 KDa Protein in Experimentally Induced Silicotic Nodule in Rat Lung." Annals of Occupational and Environmental Medicine 15, no. 2 (2003): 181–87. http://dx.doi.org/10.35371/kjoem.2003.15.2.181.

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OBJECTIVES: This study was conducted in order to understand the cellular events associated with silica-induced pathogenesis of the rat lung.METHODS: Silicosis was induced by an intratracheal instillation of 50 mg of silica (SiO2, 0.15 - 10 micrometer) suspended in 500 microliter of a sterile saline solution in Sprague-Dawley rats weighing 200g. Silicotic nodules were excised from the rat lungs 4 weeks after silica instillation, then boiled for 4 days at 110 degrees in solution containing 2% SDS, 10 M urea and 40 mM DTT. The insoluble cellular encapsulates were electrophoresed on 4-12 % gradien

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Xue, Yu, Long Miao, Ping Xu, Xinglong Yang, Man Qu, and Hanpeng Lai. "Potential Effect of Combined Exposure of Crystalline Silica Dust and Cigarette Smoking on the Incidence of Silicosis among Chinese Male Stone Processing Workers: A Cross-Sectional Study." Healthcare 11, no. 16 (2023): 2260. http://dx.doi.org/10.3390/healthcare11162260.

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Background: Silicosis is a progressive and irreversible disease primarily caused by exposure to crystalline silica dust and, to a lesser extent, cigarette smoking. However, further research is needed to validate the potential combined effect of these risk factors on the increased incidence of the disease. Methods: A total of 1688 male workers employed at a Chinese stone processing plant between 1 January 1999 and 31 December 2019, were included in the study. Cumulative exposure to industrial crystalline silica dust and packyears of smoking were collected through health surveillance, and odds r

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Ojeda Gutierrez, Francisco, Raul Marquez Preciado, Jorge Humberto Ramirez Gonzalez, et al. "Estudio comparativo de tres materiales de impresión en su capacidad para reproducir el margen cervical de la preparación mediante las técnicas de doble hilo y cofia de trasferencia." Revista de Odontologia da Universidade Cidade de São Paulo 30, no. 2 (2018): 157. http://dx.doi.org/10.26843/ro_unicidv3022018p157-168.

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En prótesis fija la integridad marginal o perfección del margen es de suma importancia así como una impresión que copie perfectamente el terminado de la preparación ya que de esto depende la adaptabilidade de la prótesis que permita la supervivencia de la restauración y el mantenimiento de la salud periodontal en la boca del paciente. En este estudio se compara la capacidad de tres materiales de impresión (2 siliconas por adición y 1 poliéter) para copiar el margen cervical de la preparación mediante las técnicas de doble hilo y cofia de trasferencia. Se utilizaron 96 primeros molares inferior

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Deivasigamani, Mohanakrishnan, Manikandan Nagesh, Balamurugan Shanthalingam, and Chandrasekar Chokalingam. "Silicosis presenting as progressive massive fibrosis: A case series." Journal of Association of Chest Physicians 12, no. 3 (2024): 124–27. http://dx.doi.org/10.4103/jacp.jacp_12_24.

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Progressive massive fibrosis (PMF) is a severe form and late-stage chronic pneumoconiosis defined by the clustering of silicotic nodules fused with connective tissue in silicosis and coal macules surrounded by fibrous tissue in coal workers’ pneumoconiosis. High levels of exposure to silica and coal mine dust are important risk factors for the development of PMF. A thorough occupational history and radiological investigation would help in the diagnosis and prevention of this condition, as there is no effective treatment. Hence, primary prevention is important as it has high mortality and morbi

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A., H. M. Nasib, H. Ahmad M., Nawawi Z., A. B. Sidik M., and I. Jambak M. "Electrical treeing and partial discharge characteristics of silicone rubber filled with nitride and oxide based nanofillers." International Journal of Electrical and Computer Engineering (IJECE) 10, no. 2 (2020): 1682–92. https://doi.org/10.11591/ijece.v10i2.pp1682-1692.

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This article presents a study on electrical treeing performances with its associated partial discharge (PD) and the influence of filler concentration in silicone rubber (SiR) samples which are filled with silicon dioxide (SiO2) and silicon nitride (Si3N4) as nanofillers for electrical tree growth suppression. There are many researches on electrical treeing in SiR with SiO2 nanofillers but none of the publication have reported on Si3N4 nanofillers for suppression of the electrical tree growth. In this study, the treeing experiments were conducted by applying a fixed AC voltage of 10 kV and 12 k

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D’Sa, Lauren, Federica Pezzuto, Francesca Lunardi, et al. "A Complex Case of Pulmonary Silico-Tuberculosis and Review of Literature." Diagnostics 13, no. 17 (2023): 2728. http://dx.doi.org/10.3390/diagnostics13172728.

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Silicosis caused by the inhalation/deposition of free silica particles is characterized by pulmonary inflammation/fibrosis. Among the clinical disorders associated with silicosis, tuberculosis is by far the most prominent. A 66-year-old male non-smoker, originally from North Africa, reported a dry cough and significant weight loss. He was a foundry worker. He had a medical history of bladder carcinoma associated with schistosomiasis. Computed tomography (CT) and positron emission tomography (PET)/CT showed bilateral multiple hypermetabolic lung nodules, some with cavitation. The patient underw

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Albuquerque, Márcio Fernando dos Santos, and Adriana Maria Coimbra Horbe. "Mineralogia, geoquímica e evolução da lateritização em Apuí, sudeste do Amazonas." Brazilian Journal of Geology 45, no. 4 (2015): 569–90. http://dx.doi.org/10.1590/2317-488920150030281.

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Análises químicas, DRX e MEV realizadas em bauxitas, crostas ferruginosas e ferro-alumino-silicosas, aliadas ao estudo do relevo, tiveram por objetivo discutir os processos que levaram a formação e preservação das crostas lateríticas ao longo do tempo geológico no sudeste do Amazonas. As crostas são maciças, pisolíticas, brechóides e vermiformes, sustentam platôs e colinas com altitudes entre 200 e 320 m e 140 e 200 m, e desenvolveram-se a partir de rochas ígneas e sedimentares dos grupos Colíder e Alto Tapajós e do Supergrupo Sumaúma. A correlação entre os produtos da lateritização e as rocha

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Rioda, Vittorio, Federica Candelato, Leidiana Mota, and Fabio Parenti. "Jazidas de rochas silicosas na área do Parque Nacional Serra da Capivara (Piauí, Brasil): primeiros dados geoarqueológicos." Revista do Museu de Arqueologia e Etnologia, no. 21 (December 9, 2011): 103. http://dx.doi.org/10.11606/issn.2448-1750.revmae.2011.89965.

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Nos artefatos líticos do Nordeste do Brasil são identificados diferentes tipos de matéria-prima silicosa, o que torna fundamental a caracterização petrográfica dessas rochas. As pesquisas desenvolvidas no abrigo da Pedra Furada levantaram questões acerca da economia da matéria-prima no Sudeste do Piauí, nos períodos do Pleistoceno e Holoceno. Porém, nenhum estudo geoarqueológico e petrográfico havia sido feito sobre os possíveis afloramentos das rochas trabalhadas na pré-história. Portanto, o objetivo desse trabalho é expor os métodos e os resultados preliminares do estudo das fontes de matéri

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Puntoni, Riccardo, David F. Goldsmith, Federico Valerio, et al. "A Cohort Study of Workers Employed in a Refractory Brick Plant." Tumori Journal 74, no. 1 (1988): 27–33. http://dx.doi.org/10.1177/030089168807400105.

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A mortality study was carried out on a cohort of workers who were exposed to silica dust in a refractory brick plant. The cohort was divided into two groups: workers with and without silicosis, and their mortality was contrasted with the death rate of Genova from 1960 to 1979. Results show an increased risk for laryngeal tumors (3 obs., 0.44 exp., SMR = 682), nonmalignant respiratory disease (16 obs., 3.2 exp., SMR = 500), and cardiovascular diseases (19 obs., 11 exp., SMR = 173) among silicotics. The mortality rate for lung cancer showed an increase for the cohort of workers as a whole (11 ob

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Jiao, Jie, Li Li, Wu Yao, Weidong Qin, Changfu Hao, and Lingeng Lu. "Influence of Silica Exposure for Lung Silicosis Rat." Disease Markers 2021 (December 13, 2021): 1–9. http://dx.doi.org/10.1155/2021/6268091.

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Objective. To investigate the influence of silica exposure on the expression of connective tissue growth factor (CTGF), transforming growth factor beta-1 (TGF-β1), and platelet-derived growth factor (PDGF) in lung silicosis rat. Methods. Wistar rats were divided into an experimental group and a control group. In the experimental group, rats were exposed to silica by intratracheal instillation. In the control group, rats were exposed to physiological saline by intratracheal instillation. After 45 days, we compared the level of fibrosis and CTGF, TGF-β1, and PDGF in the lungs by immunohistochemi

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Kim, James C. S., and Richard Cole. "Ultrastructural and microprobe analysis of simian lung mite pigments." American Journal of Veterinary Research 48, no. 3 (1987): 511–14. https://doi.org/10.2460/ajvr.1987.48.03.511.

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SUMMARY Using light microscopy, polarizable amorphorous bodies with tinctorial characteristics of lipochromes and flocculent pigmental materials were found within the alveolar macrophages and peribronchiolar region of the lungs in a pig-tailed macaque (Macaca nemistrina) infected with simian lung mite (Pneumonyssus simicola). Examination of these pigmental bodies, using a high-voltage (1.2 meV) electron microscope and an energy-dispersive X-ray analysis system, indicated that the pigmental bodies contained a high concentration of silica. One female adult P simicola also was examined, and its d

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Enzo, dos Santos Melo Véras, Bringel Fuentes Hariel, Marçal Carvalho Val Hendrix, Guilherme de Oliveira Rodrigues Ferreira¹ José, Machado Lima Thaís, and Vanessa Cristina de Castro Aragão Oliveira Orientador:. "ABORDAGEM PREVENTIVA E MEDICAMENTOSA DA SILICOSE DENTRO DO SISTEMA ÚNICO DE SAÚDE: UMA REVISÃO DE LITERATURA." RevistaFT 28, no. 128 (2023): 40. https://doi.org/10.5281/zenodo.10160640.

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<strong>Introdução:</strong> A revolução industrial aumentou a exposição a poeiras, como as encontradas na mineração, na extração e beneficiamento de rochas, na lapidação de quartzo e pedras preciosas, na construção civil, no jateamento de areia e na metalurgia. Essa exposição pode causar silicose, uma doença que causa dispneia, dor, perda de peso e febre. Em casos graves, a silicose pode evoluir para complicações, como DPOC, enfisema, câncer de pulmão, tuberculose pulmonar. <strong>Metodologia:</strong> Este artigo se trata de uma revisão de literatura sistemática, com o objetivo de  ide

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Faffe, Débora S., Gabriela H. Silva, Pedro M. P. Kurtz, et al. "Lung tissue mechanics and extracellular matrix composition in a murine model of silicosis." Journal of Applied Physiology 90, no. 4 (2001): 1400–1406. http://dx.doi.org/10.1152/jappl.2001.90.4.1400.

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The dynamic mechanical properties of lung tissue and its contents of collagen and elastic fibers were studied in strips prepared from mice instilled intratracheally with saline (C) or silica [15 (S15) and 30 days (S30) after instillation]. Resistance, elastance, and hysteresivity were studied during oscillations at different frequencies on S15 and S30. Elastance increased from C to silica groups but was similar between S15 and S30. Resistance was augmented from C to S15 and S30 and was greater in S30 than in S15 at higher frequencies. Hysteresivity was higher in S30 than in C and S15. Silica g

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CIMRIN, Arif Hikmet, and Hande BAHADIR. "Silicosis." Güncel Göğüs Hastalıkları Serisi 7, no. 2 (2020): 74–79. http://dx.doi.org/10.5152/gghs.2019.026.

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Graham, William G. B. "SILICOSIS." Clinics in Chest Medicine 13, no. 2 (1992): 253–67. http://dx.doi.org/10.1016/s0272-5231(21)00855-8.

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Ramírez, Augusto V. "Silicosis." Anales de la Facultad de Medicina 74, no. 1 (2013): 49. http://dx.doi.org/10.15381/anales.v74i1.2051.

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La silicosis es una neumoconiosis producida por inhalación repetida de polvo de sílice, caracterizada por fibrosis pulmonar y acompañada de problemas bronquíticos. Es factor predisponente para cáncer pulmonar y determina incapacidades laborales temporales o permanentes. De acuerdo a su forma de presentación, la silicosis puede ser clásica, aguda, complicada o acelerada. El Perú es un país minero con más de 197 mil trabajadores directos en esta actividad considerada de riesgo alto para contraer silicosis. El examen clínico, los antecedentes laborales, la radiografía de pulmones y la espirometrí

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Reynolds, Kimberly, and John Jerome. "Silicosis." Workplace Health & Safety 69, no. 1 (2020): 51. http://dx.doi.org/10.1177/2165079920967923.

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Gampel Cohen, Abraham, Fabiola Romero Ruperto, Francisco Javier González Sendra, María Jesús Sánchez García-Altares, and María Luz Parra Gordo. "Silicosis." Medicina General y de Familia 5, no. 4 (2016): 169–71. http://dx.doi.org/10.1016/j.mgyf.2015.12.010.

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Leung, Chi Chiu, Ignatius Tak Sun Yu, and Weihong Chen. "Silicosis." Lancet 379, no. 9830 (2012): 2008–18. http://dx.doi.org/10.1016/s0140-6736(12)60235-9.

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Terra Filho, Mario, and Ubiratan de Paula Santos. "Silicose." Jornal Brasileiro de Pneumologia 32, suppl 2 (2006): S41—S47. http://dx.doi.org/10.1590/s1806-37132006000800008.

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Os autores apresentam uma revisão da literatura nacional e internacional e discutem aspectos epidemiológicos, fisiopatológicos, funcionais e do diagnóstico da silicose. São revistas a classificação clínica, as formas de tratamento e outras doenças sílico relacionadas, como a tuberculose, o câncer de pulmão e a esclerodermia. Aspectos preventivos e médico-legais também são discutidos.

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Santos, Mónica, Armando Almeida, and Catarina Lopes. "Silicose." Revista Portuguesa de Saúde Ocupacional 13 (June 30, 2022): 157–71. http://dx.doi.org/10.31252/rpso.25.06.2022.

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Introduction/framework/objectives Pneumoconiosis are the most frequent occupational diseases. Silicosis is caused by inhaling breathable crystalline Silica. It is a diffuse interstitial fibronodular lung disease. Initially it is asymptomatic, however, it is usually progressive and without cure. The diagnosis is partially based on a history of professional exposure. It is more prevalent in countries with considerable unemployment and/or little or no Health and Safety Surveillance at Work. Methodology This is a Bibliographic Review, initiated through a search carried out in January 2022, in the

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Seaton, Anthony. "Silicosis." Occupational Medicine 73, no. 3 (2023): 170. http://dx.doi.org/10.1093/occmed/kqad017.

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Kwan, Kermit S., Daniel A. Harrington, Patricia A. Moore, James R. Hahn, Jon V. Degroot, and Gary T. Burns. "Synthesis and Use of Colloidal Silica for Reinforcement in Silicone Elastomers." Rubber Chemistry and Technology 74, no. 4 (2001): 630–44. http://dx.doi.org/10.5254/1.3544963.

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Abstract Aqueous suspensions of colloidal silicas are readily silylated with either chlorosilanes or disiloxanes in the presence of acid and isopropyl alcohol without aggregation of the silica particle. By using a mixture of chlorosilanes or disiloxanes, spherical nanoparticles with controlled functionality can be made and transferred to an organic phase to provide stable, water free suspensions. The hydrophobic silica particles readily disperse into silicone polymers. At sufficient loading levels, they provide mechanical reinforcement comparable to traditional fillers but with improved clarit

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Kang, Lulu, Jinghong Dai, Yufang Wang, et al. "Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice." PLOS Genetics 18, no. 12 (2022): e1010515. http://dx.doi.org/10.1371/journal.pgen.1010515.

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Millions of patients suffer from silicosis, but it remains an uncurable disease due to its unclear pathogenic mechanisms. Though the Nlrp3 inflammasome is involved in silicosis pathogenesis, inhibition of its classic downstream factors, Caspase-1 and Gsdmd, fails to block pyroptosis and cytokine release. To clarify the molecular mechanism of silicosis pathogenesis for new therapy, we examined samples from silicosis patients and genetic mouse models. We discovered an alternative pyroptotic pathway which requires cleavage of Gsdme by Caspases-3/8 in addition to Caspase-1/Gsdmd. Consistently, Gsd

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Pandit, Shally, Sudatta Chandan, Braja S. Barik, Tahziba Hussain, and Sanghamitra Pati. "Tuberculosis and Silicosis: an insightful perspective." Egyptian Journal of Chest Diseases and Tuberculosis 74, no. 2 (2025): 134–46. https://doi.org/10.4103/ecdt.ecdt_45_24.

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Tuberculosis (TB) is the most ubiquitous disease related to Silicosis in medium and low-income nations. The government of India has set a target to eliminate TB by 2025, while the International Labor Organization and the WHO aim to eradicate Silicosis from developing countries by 2030. However, the co-existence of Silicosis and TB poses a challenge to achieving these goals. Silica, specifically crystalline silica, is a hazardous mineral found in industries such as ceramics and construction. Silicosis severity is directly related to the augmentation of TB, and silica-exposed individuals, such a

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