Relevant bibliographies by topics / Silymarine

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Silymarine'

Author: Grafiati
Published: 4 June 2021
Last updated: 5 February 2022

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Journal articles on the topic "Silymarine"

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Bakhshaee, Mehdi, Farahzad Jabbari, Saeed Hosseini, Reza Farid Hossaini, and Mohammad Hadi Sadeghian. "Additive Effect of Silymarine in Allergic Rhinitis Treatment." Otolaryngology–Head and Neck Surgery 143, no. 2_suppl (2010): P123. http://dx.doi.org/10.1016/j.otohns.2010.06.695.

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Amala, K., R. Ilavarasan, R. Arunadevi, and S. Amerjothy. "HEPATOPROTECTIVE EVALUATION OF EPALTES DIVARICATA (L.) CASS. WHOLE PLANT EXTRACTS AGAINST PARACETAMOL-INDUCED HEPATOTOXICITY IN RATS." International Journal of Pharmacy and Pharmaceutical Sciences 8, no. 12 (2016): 231. http://dx.doi.org/10.22159/ijpps.2016v8i12.14951.

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<p><strong>Objective: </strong>The plant of <strong><em>Epaltes</em></strong><strong> <em>divaricata </em>(L.) </strong>Cass.<strong> Traditionally used for jaundice. </strong>The present work aimed to investigate the hepatoprotective activity of alcohol and aqueous extract of the whole plant against paracetamol-induced hepatotoxicity in rats to substantiate its traditional use.</p><p><strong>Methods: </strong>The alcohol and aqueous (200 and 400 mg/kg) extract of <em>Epaltes divaricata</em> prepared by cold maceration were administered orally to the animals with hepatotoxicity induced by paracetamol (1000 mg/kg). Silymarine (40 mg/k) was given as reference standard. Hepatoprotective activity was assessed by estimating marker enzymes and by histopathological studies.</p><p><strong>Results: </strong>Both alcohol and aqueous (200 and 400 mg/kg) extract treatment significantly restored the paracetamol-induced elevations in levels of serum enzymes aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphate (ALP) and total bilirubin in a dose-dependent manner. Histopathological examination revealed that the treatment attenuated the paracetamol-induced damage to the liver. The hepatoprotective effect of both extracts was comparable to that of the standard hepatoprotective agent, silymarin.</p><p><strong>Conclusion: </strong>The alcohol and aqueous extract of <em>E. divaricata</em> exhibited hepatoprotective effect against paracetamol-induced liver damage in rats. This study also validated their traditional medicinal use in jaundice.</p>
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Boyer, Jean-Christophe, Francois Hernandez, Jacques Estorc, Jean-Emmanuel De La Coussaye, and Jean-Pierre Bali. "Management of Maternal Amanita phalloı̈des Poisoning during the First Trimester of Pregnancy: A Case Report and Review of the Literature." Clinical Chemistry 47, no. 5 (2001): 971–74. http://dx.doi.org/10.1093/clinchem/47.5.971.

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Abstract Background: Amanita phalloı̈des poisoning produces acute liver failure and often death. Maternal poisonings are rare, and medical decisions of abortion or liver transplantation in this critical situation frequently are based on laboratory data. We report here the case of a 22-year-old-woman in the 11th week of pregnancy, who ingested mushrooms. Case Report: The patient’s clinical symptoms (e.g., vomiting and diarrhea) and blood chemistry data (persistent increases of aspartate aminotransferase and alanine aminotransferase and severe decreases in prothrombin, factor V, factor II, factor VII, and factor X) indicated poisoning of medium severity. The management consisted of intravenous hydration, and administration of silymarine and N-acetylcysteine. No fetal damage was observed, and birth and development of the infant (now 2 years of age) proceeded without incident. Conclusion: Abortion is not necessarily indicated in maternal poisoning by A. phalloı̈des, even in the first trimester of pregnancy.
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Murukan, Greeshma, S. S. Sumayya, J. M. Aswathy, Bosco Lawarence, and K. Murugan. "VALIDATION OF HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF FOLK LORE KNOWLEDGE OF PURIFIED ANTHOCYANIN FROM CELL SUSPENSION CULTURE OF CLERODENDRON INFORTUNATUM L.: A SEARCH." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 12 (2017): 37. http://dx.doi.org/10.22159/ijpps.2017v9i12.20042.

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ABSTRACT Objective: To validate the hepatoprotective and antioxidant activity of purified anthocyanin extracted from the cell suspension culture of Clerodendron infortunatum Linn. Methods: A protocol has been developed for the induction of callus proliferation from leaf and nodal explants of C. infortunatum. The explants were inoculated on MS medium supplemented with diverse combinations of 2,4-D and BAP for triggering callus formation. Subsequently, the green compact callus has been sub-cultured in the medium fortified with 2,4-D and Kinetin for anthocyanin synthesis. Cell suspension culture was also established and the elicitor, salicylic acid was used for triggering anthocyanin synthesis. Three different chromatographic columns (solid phase extraction by Sepharose C18 column, Oasis-MCX and Amberlite XAD 7 + Sephadex LH 120 sorbents) were employed to purify the in vitro synthesized anthocyanin from cell suspension cultures. For purity evaluation HPLC and molar absorptivity assay were used. Further, hepatoprotective and antioxidant activity was evaluated comparing with silymarine, as standard in rats. In vitro antioxidant scavenging activity was analysed by DPPH, FRAP and ORAC assay.Results: After 1 month, the leaf explants yielded remarkable green compact callus on MS medium containing 2.0 mg/l BAP and 0.5 mg/l 2,4-D. Salicylic acid enhanced anthocyanin synthesis. The mean purity values obtained by HPLC were 90.9% ± 1.9 and 80.60% ±2.3 for Oasis MCX, Amberlite XAD-7 + Sephadex LH-20 column respectively. However, the purity calculated by molar absorptivity was found to be less. The highest purity achieved using molar absorptivity analysis was with MCX cartidges i.e., 85.9 ± 3.8%. HPLC yielded 12 anthocyanin fractions. Remarkable antioxidant scavenging activity was noticed as revealed by DPPH, FRAP and ORAC assay. The hepatoprotection activity (25, 50, 100 mg/100g b.w) was compared with silymarine (25 mg/kg b.w) against CCl4 induced toxicity. Anthocyanin extract improved the AST, ALT and recovered the activity of kidney function by decreasing the urea and creatinine content. In addition, the administration of anthocyanin significantly inhibited the oxidative stress via its scavenging of the reactive oxygen species formed by CCl4 stress. Further, a decrease in the MDA, H2O2, NO accumulation and increase of GSH content were noticed. Similarly, improved lipid profiles, LDL and HDL levels were also observed suggesting that anthocyanin significantly suppress the toxicity via its activation of antioxidant enzymes (GST, CAT and SOD).Conclusion: The overall results showed that the purified anthocyanin of C. infortunatum function as an antioxidant and there by hepatoprotective protection against CCl4 inducedtoxicity in animal models.
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Shutov, D. V. "Heparprotective effect of Bergenia crassifolia extract and silymarinat experimental inhibition of β-oxidation of fatty acids causedby 4-pentenioc acid". Bulletin of Siberian Medicine 6, № 4 (2007): 64–70. http://dx.doi.org/10.20538/1682-0363-2007-4-64-70.

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The object of this research was to study rat liver bioenergetics at pathology caused by inhibition of β-oxidation of fatty acids against the background of 4-pentenoic acid injection and at silymarin and Bergenia crassifolia extract therapy. The experiment was conducted with 50 nonpedigreed male rats. The functional state of the energy production system was estimated by the polarogaphic method from the rate of oxygen consumption in different Chans metabolic states. At silymarin therapy, increase was observed in the oxidative phosphorylation coupling in all metabolic states. The Bergenia crassifolia extract favored normalization of energy production parameters in rat liver mitochondria more efficiently than silymarint did.
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Quaglia, M. G., E. Bossù, E. Donati, G. Mazzanti, and A. Brandt. "Determination of silymarine in the extract from the dried silybum marianum fruits by high performance liquid chromatography and capillary electrophoresis." Journal of Pharmaceutical and Biomedical Analysis 19, no. 3-4 (1999): 435–42. http://dx.doi.org/10.1016/s0731-7085(98)00231-3.

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El-Sheshtawy, Sahar M., Amal F. El-Zoghby, Nesreen A. Shawky, and Dalia H. Samak. "Aflatoxicosis in Pekin duckling and the effects of treatments with lycopene and silymarin." March-2021 14, no. 3 (2021): 788–93. http://dx.doi.org/10.14202/vetworld.2021.788-793.

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Background and Aim: Aflatoxins (AFs) are potent toxic metabolites produced from Aspergillus species. Whose existence in poultry ration leads to drastic economic losses, notably in duck, as the most susceptible poultry species. This study aimed to determine tissue residues of AFs, alterations in selected clinical chemistry variables in serum, mainly during the exposure period, and lycopene and silymarin's possible roles as herbal treatments against aflatoxicosis in Pekin duckling. Materials and Methods: The study used one hundred and twenty one-day-old Pekin ducklings and classified them into four groups comprising 30 ducklings in each group. The control group (G1) ducklings were fed a mycotoxin-free ration, and G2 received a naturally contaminated ration with 30 ppb of AFs. G3 and G4 consumed contaminated rations with AFs with 30 ppb for 2 weeks and were treated with lycopene 100 mg/kg or silymarin 600 mg/kg/food, respectively, for 10 days. Serum activities of alanine transaminase and alkaline phosphatase (ALP), glutamyl transferase, ALP, total protein and albumin creatinine and uric acid concentrations, oxidant/antioxidant parameters (malondialdehyde [MDA], total antioxidant capacity (TAC), glutathione S-transferase (GST), and catalase [CAT]), and hepatic AFs residue were determined. Lycopene and silymarin were used for the treatment of aflatoxicosis for another 10 days. Results: Hepatic and kidney parameters were elevated in the AFs intoxicated group and reduced in the lycopene- and silymarin-treated groups. They had elevated MDA and AFs residues with decreased antioxidant parameters (TAC, GST, and CAT) in the AFs group. At the same time, treatment with lycopene or silymarin had reversed the action of AFs on MDA, elevated the hepatic residue, and improved antioxidant activity. Conclusion: Lycopene and silymarin, with their potent antioxidant activity, can be used to reverse the harmful effects of AFs on hepatic and kidney tissue.
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Song, Im-Sook, So-Jeong Nam, Ji-Hyeon Jeon, Soo-Jin Park, and Min-Koo Choi. "Enhanced Bioavailability and Efficacy of Silymarin Solid Dispersion in Rats with Acetaminophen-Induced Hepatotoxicity." Pharmaceutics 13, no. 5 (2021): 628. http://dx.doi.org/10.3390/pharmaceutics13050628.

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We evaluated the bioavailability, liver distribution, and efficacy of silymarin-D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) solid dispersion (silymarin-SD) in rats with acetaminophen-induced hepatotoxicity (APAP) compared with silymarin alone. The solubility of silybin, the major and active component of silymarin, in the silymarin-SD group increased 23-fold compared with the silymarin group. The absorptive permeability of silybin increased by 4.6-fold and its efflux ratio decreased from 5.5 to 0.6 in the presence of TPGS. The results suggested that TPGS functioned as a solubilizing agent and permeation enhancer by inhibiting efflux pump. Thus, silybin concentrations in plasma and liver were increased in the silymarin-SD group and liver distribution increased 3.4-fold after repeated oral administration of silymarin-SD (20 mg/kg as silybin) for five consecutive days compared with that of silymarin alone (20 mg/kg as silybin). Based on higher liver silybin concentrations in the silymarin-SD group, the therapeutic effects of silymarin-SD in hepatotoxic rats were evaluated and compared with silymarin administration only. Elevated alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase levels were significantly decreased by silymarin-SD, silymarin, and TPGS treatments, but these decreases were much higher in silymarin-SD animals than in those treated with silymarin or TPGS. In conclusion, silymarin-SD (20 mg/kg as silybin, three times per day for 5 days) exhibited hepatoprotective properties toward hepatotoxic rats and these properties were superior to silymarin alone, which may be attributed to increased solubility, enhanced intestinal permeability, and increased liver distribution of the silymarin-SD formulation.
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Petrie, Michaela, Gerry McKay, and Miles Fisher. "Silymarin." Practical Diabetes 32, no. 4 (2015): 148–50. http://dx.doi.org/10.1002/pdi.1945.

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Ashraf, Aya, Passant A. Mahmoud, Haidy Reda, et al. "Silymarin and silymarin nanoparticles guard against chronic unpredictable mild stress induced depressive-like behavior in mice: involvement of neurogenesis and NLRP3 inflammasome." Journal of Psychopharmacology 33, no. 5 (2019): 615–31. http://dx.doi.org/10.1177/0269881119836221.

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Background: The neuropathology of depression is quite complex. Thus, treatment failures are frequent with current antidepressants, raising the need for more effective ones. Aims: This study aimed to investigate the influence of silymarin on depressive-like behavior induced by chronic unpredictable mild stress (CUMS) and explore the underlying mechanisms. Methods: Silymarin was formulated as nanostructured lipid carriers (a lipid-based type of nanoparticle with the advantages of physical stability, good release profile, and targeted delivery). Mice were subjected to CUMS paradigm during 14 days. During this period, mice received silymarin (200 mg/kg, p.o.) per se or in its nanoparticle form or fluoxetine (10 mg/kg, p.o.). On the 15th day behavioral and biochemical parameters were analyzed. Results: Oral administration of silymarin (200 mg/kg), particularly in its nanoparticulate form, exerted an antidepressant-like effect, comparable with fluoxetine in mice, as demonstrated in the behavioral despair tests. Silymarin also reversed prefrontal cortical and hippocampal CUMS-induced oxidative stress and neuroinflammation. Furthermore, silymarin augmented neurotransmitter levels, enhanced neurogenesis and inhibited nod-like receptor protein 3 inflammasome activation. Silymarin nanoparticles were superior to silymarin in certain parameters probably due to significantly higher brain silybinin (the major active component of silymarin) concentration by 12.46 fold in the group administered silymarin nanoparticles compared with the mice which were administered silymarin per se. Conclusions: The antidepressant-like effect of silymarin can be attributed to its antioxidant and anti-inflammatory effects as well as increased neurogenesis in the prefrontal cortex and hippocampus, which delineates silymarin, especially in nanoparticle form, as a promising strategy for treatment of depression.
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Dissertations / Theses on the topic "Silymarine"

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HEURTEBIZE, PASCALE. "Intoxication phalloidienne : a propos de cinq cas traites par ceftazidime et silymarine." Besançon, 1990. http://www.theses.fr/1990BESA3095.

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Cheignon, Clotilde. "Les produits solaires : des pistes pour améliorer leur efficacité : mise au point de méthodes in vitro d'évaluation - criblage de molécules d'intérêt." Nantes, 2012. http://archive.bu.univ-nantes.fr/pollux/show.action?id=1fb33925-ca89-48e4-994f-1c99a50c8c01.

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Après des rappels bibliographiques concernant la physiologie cutanée et les actifs utilisés dans les produits solaires, nous nous sommes attachés à développer des méthodes d'évaluation de la résistance à l'eau. Nous avons voulu démontrer qu'il était possible d'utiliser un autre type d'équipement que celui habituellement recommandé pour ce type d'études. Afin d'aider le formulateur lors de l'étape de développement des produits solaires, travail long et fastidieux, nous avons mis au point un processus rapide afin de qualifier le produit en termes de résistance à l'eau. La méthode in vitro de résistance à l'eau est, en effet, assez longue, un minimum de 40 minutes d'immersion étant requis, avec deux bains successifs séparés par des étapes de séchage. Notre travail a consisté à raccourcir la durée de cette manipulation. On a pu constater qu'un produit non résistant à l'eau perd rapidement de son efficacité (dès 5 minutes d'immersion) ce qui est très discriminant. Enfin, nous avons évalué un certain nombre de molécules d'intérêt pour augmenter la résistance à l'eau des crèmes solaires, mais aussi pour accroître leur activité en termes de filtration dans le domaine UVB et/ou UVA. Pour ce faire, nous avons eu recours au monde végétal<br>After bibliographic reminders on skin physiology and the active ingredients used in sunscreen products, we focused on developing methods for evaluating the water resistance. We wanted to demonstrate that it is possible to use another type of equipment that usually recommended for such studies. To assist the formulator in the different steps of the development of sunscreens, tedious job, we have developed a quick process to qualify the product in terms of water resistance. In vitro method for water resistance is indeed quite long, at least 40 minutes of immersion are required, with two successive baths separated by drying stages. Our job was to shorten the duration of this manipulation. It was found that a non water resistant product is rapidly losing its effectiveness (from 5 minutes of immersion) which is very telling. Finally, we evaluated a number of molecules of interest to increase the water resistance of sunscreens, but also to increase their activity in terms of filtration in the UVB and / or UVA. To do this, we used the plant world
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Trinchet, Jean-Claude. "L'hepatite alcoolique : utilisation des marqueurs seriques de fibrose, pathogenie et traitement." Aix-Marseille 2, 1994. http://www.theses.fr/1994AIX22954.

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Drouet, Samantha. "Du Chardon MARIe et de ses flavonoLIgnaNEs (MARILINE) : Valorisation de la biodiversité structurale issue de populations sauvages et cultivées pour des applications cosmétiques." Thesis, Orléans, 2019. http://www.theses.fr/2019ORLE3099.

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Plante sauvage aux multiples applications, le Chardon Marie (Silybum marianum L. Gaertn) accumule dans ses akènes un mélange de flavonolignanes (issus du couplage oxydatif de la taxifoline et de l’alcool coniférylique), nommé silymarine. Cette plante utilisée en pharmaceutique (Legalon™) grâce aux propriétés hépatoprotectrices des flavonolignanes, reste encore peu exploitée dans l’industrie cosmétique malgré de nombreuses activités biologiques, particulièrement antioxydante et anti-imflammatoire. Le développement de méthodes d’extraction et de séparation de la silymarine a permis d’étudier la variabilité naturelle des teneurs de ce mélange dans des écotypes sauvages. L’accumulation des flavonolignanes au cours de la maturation de l’akène a fait l’objet d’investigation au niveau transcriptionnel avec l’étude de l’expression de gènes impliqués dans la voie des phenylpropanoïdes et des flavonoïdes et a conduit à l’identification de gènes impliqués dans la biosynthèse des flavonolignanes. Des approches biotechnologiques ont mis en lumière l’intérêt de culture de type hairy root et de cals pour la bioproduction de masse de ces composés. Enfin la caractérisation des activités antioxydantes et antiâge des flavonolignanes naturels ou hémisynthétiques met en évidence que certains peuvent être utilisés en replacement d’antioxydants de synthèse largement décriés. L’ensemble de ces travaux constitue une base scientifique pour de futures études plus ciblées portant sur les conditions de bioproduction des flavonolignanes en vue d’application cosmétique<br>Wild plant with many applications, milk thistle (Silybum marianum L. Gaertn) accumulates in its achenes a mixture of flavonolignans (resulting from the oxidative coupling of taxifolin and coniferyl alcohol), called silymarin. This plant used in pharmaceutical (Legalon ™) thanks to the hepatoprotective properties of flavonolignans, remains underutilized in the cosmetic industry despite many biological activities, particularly antioxidant and anti-inflammatory. The development of silymarin extraction and separation methods made it possible to study the natural variability of the contents of this mixture in wild ecotypes. The flavonolignans accumulation during achene maturation has been investigated at transcriptional level with the study of genes expression involved in the pathway of phenylpropanoids and flavonoids. It led to the identification of genes involved in flavonolignans biosynthesis. Biotechnological approaches have highlighted the interest of hairy root and callus culture for the bioproduction of these compounds. Finally, the characterization of the antioxidant and anti-aging activities of natural or semisynthetic flavonolignans shows that some of them can be used as replacement for widely-decried synthetic antioxidants. This work constitutes a scientific basis for future more targeted studies on the bioproduction conditions of flavonolignans for cosmetic application
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Boutin, Elodie. "Mécanisme d'inhibition de la fusion membranaire du virus de l'hépatite C par différents composés : l'arbidol, la silymarine et les molécules la composant." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10244.

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L'infection par le virus de l'hépatite C (VHC) est un problème de santé publique majeur car en absence de vaccin et de thérapie suffisamment efficace, l’infection peut dégénérer en carcinome hépatocellulaire. Il est alors important d’identifier de nouvelles cibles thérapeutiques et de développer de nouveaux antiviraux. Ainsi, nous avons étudié l'activité anti-VHC de différents composés : l'arbidol (Arb), la silymarine (SM) et les molécules la composant, notamment la silibinine (SbN). Ces composés ont l'avantage d'être déjà utilisés en médecine humaine depuis de nombreuses années et ont ainsi prouvé leur innocuité. Ils présentent un large spectre antiviral et inhibent plusieurs étapes du cycle viral, dont la fusion membranaire. Cette étape du cycle est intéressante à cibler car le virus serait bloqué précocement, avant de provoquer des dommages cellulaires.Nous avons approfondi notre connaissance du mécanisme d'inhibition de la fusion par Arb en montrant par différentes stratégies qu'il s'associe avec les phospholipides à l'interface membranaire et interagit avec des résidus aromatiques. Cela suggère que Arb pourrait former durant le processus de fusion un complexe entre glycoprotéine virale et membrane, permettant d'inhiber les changements conformationnels de la glycoprotéine, nécessaires à la fusion. De même SM et ses composés inhibent la fusion de pseudoparticules de HCV, probablement en stabilisant les membranes impliquées dans le processus. Enfin, nous avons observé une activité antivirale et anti-inflammatoire très différente entre deux formulations de SbN. Tous ces résultats sont discutés dans le contexte actuel d'un arsenal thérapeutique anti-HCV qui reste limité<br>Infection by the hepatitis C virus (HCV) is a major public health problem since the infection can lead to hepatocellular carcinoma in the current absence of vaccine and effective treatment. It is therefore important to identify new therapeutic targets and to develop novel antiviral drugs. Here we studied the anti-HCV activity of two compounds : arbidol (Arb), the herbal extract silymarin (SM) and molecules therein, including silibinin (SbN). These compounds are already in use in human medicine for several years and have proven safety. They display a broad antiviral spectrum and inhibit several steps of the virus life cycle, including membrane fusion. This step is very interesting to target, since the virus could be blocked upstream the cellular damages it could induce. Using different biophysical strategies, we showed that Arb associates with phospholipids at the membrane interface and interacts with aromatic residues. This suggests that Arb could form during the fusion process a complex between viral glycoprotein(s) and membrane, leading to the inhibition of the conformational changes within the glycoprotein that are required during the fusion process. SM and its components inhibit fusion of HCV pseudoparticles, probably by stabilizing the membranes involved in this process. Finally, we observed different antiviral and anti-inflammatory activities between two different formulations of SbN. Knowledge of these antiviral mechanisms should lead to innovative therapeutic strategies against HCV
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Golicki, Isabelle. "Les propriétés hépatoprotectrices du chardon Marie (Silybum Marianum L. )." Paris 5, 1998. http://www.theses.fr/1998PA05P099.

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Blevins, Sarah. "Characterizing Compensatory Effects of Silymarin on Gossypol Toxicosis in Lines of Chickens Divergently Selected for Humoral Immune Response." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/34609.

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Feed costs are approximately 70% of total production cost for poultry producers. Poultry diets in the United States generally consist of 2 grains: corn and soybean meal. In recent years, the cost of these grains has dramatically increased. Due to these price increases, producers seek alternative feeds that provide adequate nutrition, and are also more affordable than â traditionalâ grains. Cottonseed meal is one alternative that is both affordable and an excellent source of crude protein. However, cottonseed meal contains gossypol, a pigment toxic to chickens. This study had two main objectives. The first objective was to determine if silymarin, an extract from milk thistle, could offset or prevent gossypol toxicosis. The second objective was to determine if divergent selection for humoral immune response would have an impact on the ability of the chicken to cope with gossypol toxicosis. Two preliminary studies were conducted. One determined basal activities of liver detoxification enzymes at various ages. The other determined concentrations of gossypol and silymarin that should be added to the diet to elicit a response. The information gathered from the second preliminary study was used to conduct the final experiment. In the final experiment, chickens from each of 2 lines selected for humoral immunity were exposed to diets containing gossypol, silymarin, gossypol and silymarin, and a control. Humoral immunity had no impact on the ability of the chicken to cope with gossypol toxicosis. Silymarin did not alleviate gossypol toxicosis. Future studies will focus on using a lower gossypol concentration in the diet.<br>Master of Science
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JÃnior, Eudmar Marcolino de Assis. "Efeito protetor da silimarina sobre a esteato-hepatite nÃo alcoÃlica experimental induzida por irinotecano." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=12657.

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O cÃncer coloretal (CRC) à a 3 neoplasia mais prevalente no mundo. O irinotecano (IRI), fÃrmaco de primeira linha para os tratamentos do CRC e sua metÃstase hepÃtica, tem aumentado a sobrevivÃncia dos pacientes. Contudo, seus efeitos colaterais, incluindo a esteato-hepatite nÃo alcoÃlica (NASH), podem limitar o curso do tratamento. Os protocolos baseados em irinotecano foram associados com um aumento no risco de NASH de 3,4 vezes. A silimarina (SIL) tem mostrado ser capaz de prevenir doenÃas do fÃgado gorduroso no contexto clÃnico e em modelos de danos hepÃticos induzidos quimicamente. Assim, nosso objetivo foi estudar o efeito da SIL na NASH induzida pelo IRI, assim como o mecanismo envolvido. MÃtodos e Resultados: Camundongos Swiss fÃmeas (n=8-10), foram divididos em 6 grupos e injetados com salina (SAL 5ml/kg i.p.), IRI (50 mg/kg i.p.), SIL (150 mg/kg v.o.) ou IRI (50 mg/kg i.p.) + SIL (SIL 1,5, 15, 150 mg/kg v.o.) 3x/semana/7 semanas. Amostras de sangue foram coletadas na sÃtima semana para determinar a concentraÃÃo sÃrica das enzimas hepÃticas ALT e AST (U/L). Animais foram mortos para a coleta do fÃgado para avaliar do dano tecidual (escores de Kleiner), dosagem de lipÃdeos totais (mg/g de tecido), MDA (nmol/g tecido), NPSH (mg de NPSH/g tecido), IL-6 (pg/mg de tecido), IL-10 (pg/mg de proteÃna) e IL-1&#946; (pg/mg de tecido), imunomarcaÃÃo de Ãxido nÃtrico sintase induzida (iNOS), 3-Nitrotirosina (Ntyr), e Receptor Toll Like tipo 4 (TLR4), quantificaÃÃo do fator nuclear kappa B (NF&#954;B) e da &#945;-actina de mÃsculo liso (&#945;-SMA) e expressÃo do gene RSS. ANOVA/Teste de Newman-Keuls ou Kruskal Wallis/ Teste de Dunn foram utilizados para anÃlise estatÃstica. Foram consideradas diferentes amostras onde o nÃvel descritivo era inferior a 5%. O trabalho foi aprovado pelo comità de Ãtica em pesquisa animal sob o nÃmero de protocolo: 21/12. O IRI aumentou de forma significante as transaminases hepÃticas, o infiltrado neutrofÃlico, o acÃmo de lipÃdeos, o acÃmulo de MDA, a expressÃo de NTyr, a expressÃo de &#945;-SMA, a expressÃo de NF&#954;B, a expressÃo de IL-1&#946;, a expressÃo de IL-6, a expressÃo de TLR4 e quantificaÃÃo de DNA bacteriano, quando comparados ao grupo SAL. SIL (1,5 mg/kg) melhorou esses parÃmetros, exceto a infiltraÃÃo neutrofÃlica e a quantificaÃÃo do DNA bacteriano quando comparados ao o grupo IRI (P<0,05). Por outro lado, a dose media de SIL (15 mg/kg) foi efetiva apenas no Infiltrado NeutrofÃlico, na expressÃo de NTyr, na expressÃo de NF&#954;B e na expressÃo de IL-6. Adicionalmente, essa dose aumentou a expressÃo hepÃtica de IL-10, a quantificaÃÃo de DNA bacteriano e a expressÃo da &#945;-SMA quando comparados com o grupo IRI (p<0,05). Contudo, a expressÃo de iNOS nÃo foi afetada pelo prÃ-tratamento com SIL (P<0,05) e a maior dose foi ainda mais deletÃria. ConclusÃes: O prÃ-tratamento com SIL previne o dano hepÃtico causado pelo IRI provavelmente atravÃs da mudanÃa da resposta inflamatÃria mediada por receptores TLR4 e citocinas IL-1, IL-6, IL-10 e NF&#954;B. O dano observado no grupo de animais tratados com as maiores doses de SIL parece ser dependente da translocaÃÃo bacteriana do intestido que à associada a ativaÃÃo do TLR4. Adicionalmente, a silimarina contribui para hepatoproteÃÃo por inibir o estresse oxidativo e a nitrosilaÃÃo proteica, prevenindo a ativaÃÃo de mecanismos de fibrose hepÃtica
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Kováčová, Ivana. "Stanovení biologicky aktivních látek ve vybraných přírodních rostlinných extraktech." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2016. http://www.nusl.cz/ntk/nusl-240571.

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This thesis is focused on the study of the effectiveness of active ingredients from natural extracts such as milk thistle and turmeric. The thesis describes the use of modern methods of analysis and identification of active substances located in plants of milk thistle and turmeric. In the experimental part of thesis, which was preceded by a literature search focused on the biological effects of active substances in the chosen natural extracts, the extracts were characterized according to group characteristics (total assessment of polyphenols and flavonoids, assessment of antioxidant activity, and assessment of vitamin C volume and tocopherol). The next part is focused on the study of the encapsulation of natural active substances into the organic particles: liposomes. Silymarin and curcumin were encapsulated as active substances. The idea of a plant with a single active ingredient is usually erroneous. Plants usually contain hundreds of components which cooperate on a given effect. Therefore, the majority of herbalists believe that a simple plant is an active ingredient. However, some plants are known to be containing a particular active phytochemical. For instance, plants such as the milk thistle, turmeric, or a ginkgo are great examples of the plant containing a particular active phytochemical. In these cases, the active compound is disproportionately more effective than the plant itself. Encapsulation efficiency of active ingredients of Silymarin and curcumin was determined by HPLC/PDA. The aim of the analysis was to observe the behavior of elements during the incubation in surrounding of gastric juice model, and the stability while maintaining the particles in model food.
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Williams, Jeanne. "The effects of hops (Humulus lupulus L.) and silymarin on performance and health of newly weaned pigs." Thesis, Open University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437778.

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The ban of antimicrobial growth promoters in pig production has resulted in an increased interest in investigating the effects of different alternatives, which can reduce the problems post weaning and improve the performance in piglets. Initially two botanical extracts with different properties were investigated: hops, which have antibacterial properties and silymarin, which is used for liver disorders. The first experiment showed that hops and silymarin had beneficial effects on FCR in piglets (P = 0.014) by 9.6% and 15.8%, respectively. Furthermore, hops significantly improved someo f the measuredli ver enzymes,s o it was decidedt o focus on hops only. Two further experiments were carried out examining the effects of different concentrations of hops and isolated hop compounds (iso-a acids and ß-acids), and the combination with organic acids in weanerp igs. A higher inclusion level of hops was associatedw ith a better FCR, and the isolated hop compounds also resulted in an improved FCR (P = 0.027) by 9.2%. The addition of an organic acid mixture did not affect the performance. An in vitro experiment confirmed that hops and isolated hop compounds had antibacterial properties. To try and elucidate the mechanism by which the hops and the isolated hop compounds improved the FCR, the effects on the gut flora were studied in the piglets. Both the hops and the iso-a acids and ß-acids reduced the level of lactic acid bacteria and the level of Bacteriodes in one of the two experiments, but no effects were seen on the other bacteria. This lead to investigate the effects of hops/isolated hop compounds on the level of volatile fatty acids, digestibility and level of digestive enzymes and level of liver enzymes. However, none of these parameters gave conclusive results about the mode of action of hops/isolated hop compounds in the piglet.
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Book chapters on the topic "Silymarine"

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Chan, M. K., and W. L. Ng. "Silymarin Ameliorates Gentamicin Nephrotoxicity." In Nephrotoxicity. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4757-2040-2_29.

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Neha, Amteshwar S. Jaggi, and Nirmal Singh. "Silymarin and Its Role in Chronic Diseases." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-41342-6_2.

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Corchete, Purificación. "Silybum marianum (L.) Gaertn: the Source of Silymarin." In Bioactive Molecules and Medicinal Plants. Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-74603-4_6.

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Duan, Lijun, Danielle Julie Carrier, and Edgar C. Clausen. "Silymarin Extraction from Milk Thistle Using Hot Water." In Proceedings of the Twenty-Fifth Symposium on Biotechnology for Fuels and Chemicals Held May 4–7, 2003, in Breckenridge, CO. Humana Press, 2004. http://dx.doi.org/10.1007/978-1-59259-837-3_46.

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Weyhenmeyer, Roland, G. Krumbiegel, and W. Wächter. "Bioavailability of silymarin, a purified extract from Silybum marianum." In Phytopharmaka V. Steinkopff, 1999. http://dx.doi.org/10.1007/978-3-642-58709-2_9.

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Vonnahme, F. J. "Der antifibrotische Effekt des Silymarins in der Therapie chronischer Lebererkrankungen." In Phytopharmaka II. Steinkopff, 1996. http://dx.doi.org/10.1007/978-3-642-85436-1_13.

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Arya, Aditya, Subhojit Paul, and Anamika Gangwar. "Silymarin—A Scintillating Phytoantioxidant: Clinical Applications and Bio-delivery Problems." In Novel Drug Delivery Systems for Phytoconstituents. CRC Press, 2019. http://dx.doi.org/10.1201/9781351057639-11.

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Tabarzad, Maryam, Fatemeh Ghorbani-Bidkorbeh, and Tahereh Hosseinabadi. "Improved Silymarin Characteristics for Clinical Applications by Novel Drug Delivery Systems." In Novel Drug Delivery Systems for Phytoconstituents. CRC Press, 2019. http://dx.doi.org/10.1201/9781351057639-10.

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Ferenci, P., B. Dragosics, H. Dittrich, et al. "Silymarin Treatment in Patients with Cirrhosis of the Liver — a Prospective Study." In Assessment and Management of Hepatobiliary Disease. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-72631-6_49.

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"Silymarin." In Cosmeceuticals and Active Cosmetics. CRC Press, 2015. http://dx.doi.org/10.1201/b18895-15.

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Conference papers on the topic "Silymarine"

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Piazzini, V., MD Ambrosio, C. Luceri, et al. "Preparation, characterization and in vitro evaluation of novel silymarin-loaded nanomicelles." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399811.

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Kaya, Ece. "Investigation of Effects of Commercial Plant-Based Silymarin on Human Lung Adenocarcinoma Cells." In 15th International Congress of Histochemistry and Cytochemistry. LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.pp-19.

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Çömlekçi, Emre. "Effects of a newly synthesized nano-silymarin compound on human breast cancer cell line." In 15th International Congress of Histochemistry and Cytochemistry. LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.pp-127.

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Mayr, S., S. Strasser, CG Kirchler, et al. "Quantification of Silymarin in Silybum marianum with near-infrared spectroscopy: a comparison of benchtop vs. handheld devices." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399771.

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Chakrabarty, Purba, Saubhik Ghosh, Mayukh Mukherjee, et al. "P071 Silymarin-choline combination versus ursodeoxycholic acid in non-alcoholic fatty liver disease: a randomised double-blind clinical trial." In Abstracts of the British Association for the Study of the Liver Annual Meeting, 22–24 November 2021. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2021. http://dx.doi.org/10.1136/gutjnl-2021-basl.80.

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Prasad, Ram, and Santosh K. Katiyar. "Abstract 1845: Silymarin, a phytochemical from milk thistle, inhibits ultraviolet radiation-induced apoptosis by stimulating DNA repair in skin cells." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-1845.

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"The Protective Effect of Withania somnifera Root Extract Against Acetaminophen Induced Liver Toxicity in Cyprinus carpio Compared to Silymaryn." In International Conference on Chemical, Environment & Biological Sciences. International Institute of Chemical, Biological & Environmental Engineering, 2014. http://dx.doi.org/10.15242/iicbe.c914122.

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Vaid, Mudit, Ram Prasad, Tripti Singh, Craig A. Elmets, Hui Xu, and Santosh K. Katiyar. "Abstract 1082: Silymarin, a phytochemical from milk thistle, inhibits UVB-induced immune suppression through DNA repair-dependent activation of dendritic cells and stimulation of effector T cells ." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-1082.

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