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1

Ng, TP, and SL Chan. "Lung function in relation to silicosis and silica exposure in granite workers." European Respiratory Journal 5, no. 8 (1992): 986–91. http://dx.doi.org/10.1183/09031936.93.05080986.

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Lung function tests (forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and FEV1/FVC %) were related to silica exposure and the extent of radiological opacities in a study of 206 active and 132 previously employed granite workers from two quarries. The investigations included detailed personal interviews, spirometric testing and radiographic examination of the chest. The chest X-ray films were read randomly and independently by three readers, using International Labour Office (ILO) standard films. Cumulative exposure to respirable silica (mg.m-3-yr) and total granite du
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2

Lucas, C. D., N. Amft, and P. T. Reid. "Systemic lupus erythematosus complicating simple silicosis." Occupational Medicine 64, no. 5 (2014): 387–90. http://dx.doi.org/10.1093/occmed/kqu060.

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3

Priego-Torres, Blanca, Daniel Sanchez-Morillo, Ebrahim Khalili, Miguel Angel Conde-Sánchez, Andrés García-Gámez, and Antonio Leon-Jimenez. "Automated engineered-stone silicosis screening and staging using Deep Learning with X-rays." Computers in Biology and Medicine Journal 191, no. 110153 (2025): 1–15. https://doi.org/10.1016/j.compbiomed.2025.110153.

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Silicosis, a debilitating occupational lung disease caused by inhaling crystalline silica, continues to be a significant global health issue, especially with the increasing use of engineered stone (ES) surfaces containing high silica content. Traditional diagnostic methods, dependent on radiological interpretation, have low sensitivity, especially, in the early stages of the disease, and present variability between evaluators. This study explores the efficacy of deep learning techniques in automating the screening and staging of silicosis using chest X-ray images.Utilizing a comprehensive data
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4

Jiménez-Gómez, Gema, Antonio Campos-Caro, Alejandro García-Núñez, Alberto Gallardo-García, Antonio Molina-Hidalgo, and Antonio León-Jiménez. "Analysis of Immune Cell Subsets in Peripheral Blood from Patients with Engineered Stone Silica-Induced Lung Inflammation." International Journal of Molecular Sciences 25, no. 11 (2024): 5722. http://dx.doi.org/10.3390/ijms25115722.

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Silicosis caused by engineered stone (ES-silicosis) is an emerging worldwide issue characterized by inflammation and fibrosis in the lungs. To our knowledge, only a few reports have investigated leukocyte/lymphocyte subsets in ES-silicosis patients. The present study was designed to explore the proportions of the main lymphocyte subsets in ES-silicosis patients stratified into two groups, one with simple silicosis (SS) and the other with a more advanced state of the disease, defined as progressive massive fibrosis (PMF). The proportions of B (memory and plasmablasts) cells, T (helper, cytotoxi
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5

Campos-Caro, Antonio, Gema Jiménez-Gómez, Alejandro García-Núñez, Antonio Hidalgo-Molina, and Antonio León-Jiménez. "Plasma Cytokine Profiling Reveals Differences between Silicotic Patients with Simple Silicosis and Those with Progressive Massive Fibrosis Caused by Engineered Stone." International Journal of Molecular Sciences 24, no. 2 (2023): 1541. http://dx.doi.org/10.3390/ijms24021541.

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Engineered stone silicosis has become an occupational epidemic disease that progresses rapidly to progressive massive fibrosis with respiratory failure and death, and there is no effective treatment. Silica deposition in the lung triggers a series of inflammatory reactions with the participation of multiple cytokines and cellular mediators whose role in the development and progression of the disease is largely unknown. We hypothesized that differences in plasma cytokine levels exist between patients diagnosed with simple silicosis (SS) and patients diagnosed with progressive massive fibrosis (
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6

Violante, Benedetto, Vito Brusasco, and Gianfranco Buccheri. "Exercise Testing in Radiologically-limited, Simple Pulmonary Silicosis." Chest 90, no. 3 (1986): 411–15. http://dx.doi.org/10.1378/chest.90.3.411.

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7

Paolucci, Valentina, Riccardo Romeo, Antonietta Gerardina Sisinni, Dusca Bartoli, Maria Antonietta Mazzei, and Pietro Sartorelli. "Silicosis in Workers Exposed to Artificial Quartz Conglomerates: Does It Differ From Chronic Simple Silicosis?" Archivos de Bronconeumología (English Edition) 51, no. 12 (2015): e57-e60. http://dx.doi.org/10.1016/j.arbr.2015.06.003.

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8

Paolucci, Valentina, Riccardo Romeo, Antonietta Gerardina Sisinni, Dusca Bartoli, Maria Antonietta Mazzei, and Pietro Sartorelli. "Silicosis en trabajadores expuestos a conglomerados artificiales de cuarzo: ¿es distinta a la silicosis crónica simple?" Archivos de Bronconeumología 51, no. 12 (2015): e57-e60. http://dx.doi.org/10.1016/j.arbres.2014.12.010.

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9

Greaves, Ian A. "Not-so-simple silicosis: A case for public health action." American Journal of Industrial Medicine 37, no. 3 (2000): 245–51. http://dx.doi.org/10.1002/(sici)1097-0274(200003)37:3<245::aid-ajim1>3.0.co;2-2.

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10

Van Loon, Nele, Thérèse Lapperre, David Ruttens, et al. "P-501 THE SI-BRE STUDY PROTOCOL: ‘ASSESSING THE DIAGNOSTIC VALUE OF ‘BREATHOMICS’ IN THE OCCUPATIONAL HEALTH SETTING FOR THE EARLY DETECTION OF INTERSTITIAL LUNG DISEASES, SUCH AS SILICOSIS.’." Occupational Medicine 74, Supplement_1 (2024): 0. http://dx.doi.org/10.1093/occmed/kqae023.1256.

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Abstract Introduction Silicosis is a pneumoconiosis resulting from the inhalation of respirable crystalline silica (RCS). It is widely acknowledged that occupational exposure to RCS occurs in various industries. In occupational health practice, silicosis is mainly detected when the disease is already advanced. Early detection of RCS-exposure is necessary to assess the exposure risk and prevent possible lung damage. This observational study aims to validate a simple, non-invasive diagnostic breath test for the early detection of silicosis in an at-risk population by correlating breath analysis
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11

Bégin, R., S. Massé, P. Sébastien, M. Martel, M. Geoffroy, and J. Labbé. "Late Aluminum Therapy Reduces the Cellular Activities of Simple Silicosis in the Sheep Model." Journal of Leukocyte Biology 41, no. 5 (1987): 400–406. http://dx.doi.org/10.1002/jlb.41.5.400.

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12

Zainal, Zainal, Erwin Azizi Jayadipraja, and Abdul Aziz Harun. "Factors Affecting the Incidence of Disease Due to Employment Relationship at PT. Indrabakti Mustika North Konawe." Waluya The International Science of Health Journal 2, no. 4 (2023): 205–9. http://dx.doi.org/10.54883/wish.v2i4.556.

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Background: The results of interviews with 10 workers illustrate that aspects of workers' health are disturbed, namely many workers who have suffered injuries, decreased attendance due to illness, exposure to mineral dust from the location or conditions of mining areas with dry and sandy soil structures that can cause silicosis or exposure to noise sourced from the operation of work tools. The purpose of the study is to determine the factors related to diseases due to labor relations in nickel mine workers at PT. IndrabaktiMustikaKonawe North.&#x0D; Methods: This study uses a Cross sectional S
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Noor-ul-Huda, Musfra Maham Dr. Mussarat Sharif. "HEALTH FACILITIES TO THE TUBERCULOSIS PATIENTS AT NISHTER HOSPITAL MULTAN." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 11 (2018): 12742–47. https://doi.org/10.5281/zenodo.1492846.

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<em>Tuberculosis (TB) is a communicable disease caused by </em>Mycobacterium tuberculosis (MTB).<em> Developing countries are facing mortality rate as higher as 95% due to MTB. MTB prevalence in adults is more common. The children, elderly and teenagers are also at risk of developing MTB. Tuberculosis patients are at high risk of mortality. It is among top 5 dangerous diseases of the world due to the reason of warranting greater deaths in females of ages between 15-44 years. The mortality rate for MTB has reduced to 47% from 1990 till 2015. </em> <em>Objective: &nbsp;The objective was to highl
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14

Li, Yong, Yanxin Sun, Jingqi Han, Hualong Yu, Chuanyu Zhang, and Cuini Yu. "Pathological Examination and Differential Diagnosis of Pulmonary Ground-Glass Opacities by CT-Guided Percutaneous Needle Biopsy." Journal of Medical Imaging and Health Informatics 11, no. 3 (2021): 912–20. http://dx.doi.org/10.1166/jmihi.2021.3522.

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In order to explore the pathological examination and differential diagnosis of pulmonary ground-glass opacities (GGO) with CT-guided percutaneous needle biopsy (CTPNB), this study retrospectively analyzed the medical records of 120 cases of patients who were diagnosed with pulmonary GGO and underwent CTPNB in a hospital designated by this study from December 2014 to December 2018. The results showed that all the 120 cases of patients were successfully punctured at one time and obtained sufficient tissue specimens with the puncture success rate and diagnostic accuracy both of 100%, being able t
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15

Marques, Ana Carolina Machado Guimarães Gonçalves, David Versalli Souza, Henrique Melo Xavier, Isabela Pinto De Medeiros, Angela Santos Ferreira Nani, and Marcos César Santos De Castro. "EXISTE DIFERENÇA NA FUNÇÃO PULMONAR ENTRE PACIENTES COM SILICOSE SIMPLES E COMPLICADA?" REVISTA FOCO 17, no. 1 (2024): e4097. http://dx.doi.org/10.54751/revistafoco.v17n1-189.

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Introdução: A silicose é uma doença pulmonar fibrosante e irreversível, causada pela inalação de cristais de sílica. A exposição à sílica é um fator independente para o enfisema pulmonar. Diversos autores descrevem que o maior comprometimento do parênquima pulmonar pela silicose ocasionaria um maior impacto funcional pulmonar. Entretanto, há estudos com resultados controversos sobre esta associação. Objetivos: Comparar os parâmetros funcionais (CVF%, VEF1/CVF e VEF1%) entre pacientes com silicose simples e complicada em acompanhamento regular no ambulatório de doenças ocupacionais do HUAP/UFF.
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16

Komati, Srinivas, Kenrick M. Lewis, Debarshi Dasgupta, Kalyanachakravarthi Kothapalli, Abirami Srikanth, and Alok Sarkar. "Leach-resistant Pt nanoparticles on a silica support serving as a clean, efficient, and recyclable catalyst for solvent-free hydrosilylation." Green Chemistry 23, no. 22 (2021): 9071–77. http://dx.doi.org/10.1039/d1gc02759j.

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17

Macias, Eddyn Ruben, Diana Margarita Iñahuazo, Diana Elizabeth Peñaloza, and María de Lourdes Garcés. "CIRUGÍA DE CÁNCER DE PULMÓN EN ESTADIO TEMPRANO EN LESIÓN CAVITARIA QUE SIMULABA ABSCESO PULMONAR, REPORTE DE CASO." Revista Medica Vozandes 32, no. 1 (2021): s11—s12. http://dx.doi.org/10.48018/rmv.v32.i1.s6.

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Introduction Pulmonary cavitations are defined as a space filled with air, within a pulmonary area of consolidation, a mass or a nodule, they are produced by the expulsion or drainage of the necrotic part of the lesion through the bronchial tree. The most frequent causes are infectious by mycobacteria as in tuberculosis, or bacteria as in necrotizing pneumonia, pulmonary abscesses, although on rare occasions, it can also present in pulmonary embolism with infarction. Neoplasms should always be suspected, being squamous cell carcinoma the one that has been related to a greater extent to pulmona
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18

Patnana, Arun Kumar, Ankita Chugh, Vinay Kumar Chugh, and Shashank Shekhar. "Simple and novel technique for fabrication of prosthetic vaginal dilators." BMJ Case Reports 12, no. 4 (2019): e229524. http://dx.doi.org/10.1136/bcr-2019-229524.

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Vaginal agenesis is one of the major congenital anomalies affecting women. Postoperative prosthetic vaginal dilators are indicated in patients treated surgically for vaginal agenesis. Although different dental materials such as acrylics and silicone-coated materials are used, addition silicones alone have never been used for the fabrication of prosthetic vaginal dilators. Addition silicone materials have advantages, such as high elastic recovery, high tear and tensile strengths, which aid in the definitive use of vaginal dilators. Vaginal dilators fabricated using addition silicone materials a
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19

D. Jhajharia, S. Deb Barma, and G. Agrawal. "Comparison of Simpler Radiation-Based ET Models with Penman Monteith model for Humid Region." Journal of Agricultural Engineering (India) 41, no. 4 (2004): 32–36. http://dx.doi.org/10.52151/jae2004414.1102.

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The three relatively simpler radiation-based models: Ture, Jensen-Haise and Priestley-Taylor were used to estimate reference evapotranspiration (ET0&gt; at different humid locations of Assam, India. The Penman-Monteith model was selected as the standard for evaluating the performance of the other three radiation-based models. The averaged monthly meteorological data were used for estimating the ETo' Good correlation was found between ETo values estimated by each of the three radiation-based models. The least and the highest values of RMSE varied between 0.16 (Gohpur) and 0.82 (Dhubri) for Prie
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20

Li, Zhe, Xinsheng Wang, Haoyu Bai, and Moyuan Cao. "Advances in Bioinspired Superhydrophobic Surfaces Made from Silicones: Fabrication and Application." Polymers 15, no. 3 (2023): 543. http://dx.doi.org/10.3390/polym15030543.

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As research on superhydrophobic materials inspired by the self-cleaning and water-repellent properties of plants and animals in nature continues, the superhydrophobic preparation methods and the applications of superhydrophobic surfaces are widely reported. Silicones are preferred for the preparation of superhydrophobic materials because of their inherent hydrophobicity and strong processing ability. In the preparation of superhydrophobic materials, silicones can both form micro-/nano-structures with dehydration condensation and reduce the surface energy of the material surface because of thei
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Butruk, Beata, Paulina Ziętek, and Tomasz Ciach. "Simple method of fabrication of hydrophobic coatings for polyurethanes." Open Chemistry 9, no. 6 (2011): 1039–45. http://dx.doi.org/10.2478/s11532-011-0094-7.

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AbstractThe aim of this study was to develop a method of manufacturing versatile hydrophobic coatings for polymers. Authors present a simple technique of polyurethane (PU) surface modification with covalently attached silicones (PDMS) or fluorocarbons (PFC). Diisocyanates were applied as linker molecules. The obtained coatings were characterized using spectroscopic analysis (FTIR), scanning acoustic microscopy (SAM) and water contact angle measurements. FTIR analysis revealed high efficiency of grafting reaction. The results of contact angle measurement indicated significant increase of hydrop
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22

Enthaler, Stephen, Angela Köhler-Krützfeldt, Benedict Heyder, and Daniel Woelki. "Iron-catalyzed depolymerizations of end-of-life silicones with fatty alcohols." Resource-Efficient Technologies, no. 2 (December 15, 2015): 73–79. http://dx.doi.org/10.18799/24056529/2015/2/38.

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During the last decades, polymers became one of the major materials in our society and a future without polymers is hardly imaginable. However, as negative issue of this success enormous amount of end-of-life materials are accumulated, which are mainly treated by landfill storage, thermal recycling or down-cycling. On the other hand, feedstock recycling can be an interesting option to convert end-of-life polymers to highquality polymers, via depolymerization reactions to low-molecular weight building blocks and subsequent transformation via polymerization reactions. In this regard, we present
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23

FERREIRA, ÂNGELA, JOSE DA SILVA MOREIRA, REGINA CAETANO, JOSÉ MANOEL GABETTO, and THEREZA QUIRICO-SANTOS. "Caracterização imunofenotípica das subpopulações de linfócitos do lavado broncoalveolar de pacientes com silicose." Jornal de Pneumologia 26, no. 3 (2000): 107–12. http://dx.doi.org/10.1590/s0102-35862000000300002.

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A lavagem broncoalveolar é um procedimento simples e seguro, na avaliação das pneumopatias relacionadas à exposição a poeiras minerais. O objetivo do estudo foi caracterizar as subpopulações celulares no lavado broncoalveolar (LBA) de pacientes silicóticos. A lavagem broncoalveolar foi realizada em 26 trabalhadores com diferentes formas de silicose: forma simples (n = 12), complicada (n = 13) e um paciente com a forma aguda da doença. Como grupo controle, foram incluídos sete indivíduos sadios. Os pacientes com silicose apresentaram intensa pleocitose com predomínio de macrófagos alveolares e
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Racles, Carmen, Adrian Bele, Ana-Lavinia Vasiliu, and Liviu Sacarescu. "Emulsion Gels as Precursors for Porous Silicones and All-Polymer Composites—A Proof of Concept Based on Siloxane Stabilizers." Gels 8, no. 6 (2022): 377. http://dx.doi.org/10.3390/gels8060377.

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In spite of its versatility, the emulsion templating method is rather uncommon for the preparation of porous silicones. In this contribution, two siloxane-containing stabilizers, designed to be soluble in polar (water) and non-polar (toluene) solvents, respectively, were used in low concentrations to produce stable emulsions, wherein polysiloxane gels were obtained by UV-photoinitiated thiol-ene click cross-linking. The stabilizers exhibited negative interfacial tension, as measured by Wilhelmy plate tensiometry. The emulsion gels evolved into porous silicones (xerogels), with tunable morpholo
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25

Naylor, G. R. S., C. J. Veitch, R. J. Mayfield, and R. Kettlewell. "Fabric-Evoked Prickle." Textile Research Journal 62, no. 8 (1992): 487–93. http://dx.doi.org/10.1177/004051759206200809.

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A simple subjective test method is described to evaluate the prickliness of fabric samples, and its reproducibility and consistency are assessed. The test is used to evaluate the prickliness of a set of wool knitted samples covering a range of fiber diameters. The finer (19 micron) wool samples are nonprickly, and prickle increases as the mean fiber diameter increases. Reducing fiber/fiber friction with silicones reduces prickle, suggesting that a reduction of fiber/fiber friction is an important mechanism in antiprickle treatments.
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Nguyen, Lien, Mimi Hang, Wanxin Wang, et al. "Simple and Improved Approaches to Long-Lasting, Hydrophilic Silicones Derived from Commercially Available Precursors." ACS Applied Materials & Interfaces 6, no. 24 (2014): 22876–83. http://dx.doi.org/10.1021/am507152d.

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27

Zulkiflee, Izzat, Syafira Masri, Mazlan Zawani, et al. "Silicon-Based Scaffold for Wound Healing Skin Regeneration Applications: A Concise Review." Polymers 14, no. 19 (2022): 4219. http://dx.doi.org/10.3390/polym14194219.

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Silicon has made its breakthrough in various industries, including clinical and biomedical applications. Silicon-based biomaterials that were fabricated into various types of scaffolds may attract interest due to their highly favorable properties covering their excellent biocompatibility, high surface area, mechanical strength, and selectivity depending on their application including film, hydrogel, nanoparticles, and so on. Silicon-based materials have also shown exciting results involving cell culture, cell growth, as well as tissue engineering. In this article, a simple review compromising
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28

Capitani, Eduardo Mello de, and Eduardo Algranti. "Outras pneumoconioses." Jornal Brasileiro de Pneumologia 32, suppl 2 (2006): S54—S59. http://dx.doi.org/10.1590/s1806-37132006000800010.

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As pneumoconioses mais prevalentes são a silicose, a asbestose e a pneumoconiose do trabalhador do carvão. Outras pneumoconioses com repercussões clínicas, funcionais e estruturais distintas são causadas pela inalação de poeiras metálicas a partir de fumos metálicos e sais orgânicos. A distinção quanto à forma química do composto inalado tem relação com a reação tecidual e o prognóstico. São apresentadas de forma sucinta a pneumoconiose simples, a siderose, a pneumoconiose por rocha fosfática, e a doença pulmonar crônica pelo berílio e por exposição a metais duros. Uma anamnese ocupacional com
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29

Heinz, Daniel, Elkin Amado, and Jörg Kressler. "Polyphilicity—An Extension of the Concept of Amphiphilicity in Polymers." Polymers 10, no. 9 (2018): 960. http://dx.doi.org/10.3390/polym10090960.

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Recent developments in synthetic pathways as simple reversible-deactivation radical polymerization (RDRP) techniques and quantitative post-polymerization reactions, most notoriously ‘click’ reactions, leading to segmented copolymers, have broadened the molecular architectures accessible to polymer chemists as a matter of routine. Segments can be blocks, grafted chains, branchings, telechelic end-groups, covalently attached nanoparticles, nanodomains in networks, even sequences of random copolymers, and so on. In this review, we describe the variety of the segmented synthetic copolymers landsca
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30

Dewi, Ariyanti Suhita. "Application of docking method to assess the activity of hydrocarbonoclastic bacteria (HCB) from marine origin in bioremediation process." Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology 6, no. 2 (2010): 45. http://dx.doi.org/10.15578/squalen.v6i2.60.

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Hydrocarbons are one of the main sources of acute and chronic stressors in marine environmentthat are potentially damaging the ecosystem if not properly overcame. As an attempt to restore theenvironment, microbial degradation is a logical solution owing to its low cost and environmentalfriendliness. Screening of microbes with bioremediation activities can be performed in vitrobymeans of high throughput screening (HTS) and/or in silicovia docking method. The latter haspractical advantages over the first in terms of time and cost. In this review, the use of virtualscreening is demonstrated to an
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31

Pelrine, Ron, and Roy Kornbluh. "Variable-Stiffness–Mode Dielectric Elastomer Devices." Advances in Science and Technology 61 (September 2008): 192–201. http://dx.doi.org/10.4028/www.scientific.net/ast.61.192.

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Dielectric elastomers, or more precisely dielectric polymers, are a relatively new class of materials for variable-stiffness and variable-damping devices. Dielectric elastomers offer significant potential advantages compared with previous variable stiffness smart materials. Advantages include simplicity, broad dynamic range, ability to reach zero stiffness, low cost, minimal mass, shock tolerance, simple drive circuitry, and design flexibility. Dielectric elastomer devices in the variable-stiffness mode convert electrical and mechanical energy back and forth to change mechanical impedance. Thi
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Szindler, Magdalena Monika, Marek Szindler, Krzysztof Lukaszkowicz, et al. "The Use of ZnO Quantum Dots to Improve the Electrical Properties of Silicon Solar Cells." Materials 18, no. 4 (2025): 861. https://doi.org/10.3390/ma18040861.

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Silicon-based solar cells dominate the photovoltaic market, with commercial monocrystalline silicon cells reaching efficiencies as high as 27.3% by May 2024. An alternative to monocrystalline silicon solar cells is polycrystalline solar cells. Despite their lower efficiency (record: 23.81%), their manufacturing process is simpler and cheaper, and their energy conversion efficiency is less sensitive to temperature changes. However, limitations persist in optical and electrical losses, particularly underutilizing ultraviolet (UV) radiation due to silicon’s bandgap. To address these issues, the a
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33

Ferreira, Ângela Santos, Valéria Barbosa Moreira, Hevânia Mara Vaz Ricardo, Renata Coutinho, José Manoel Gabetto, and Edson Marchiori. "Fibrose maciça progressiva em trabalhadores expostos à sílica: achados na tomografia computadorizada de alta resolução." Jornal Brasileiro de Pneumologia 32, no. 6 (2006): 523–28. http://dx.doi.org/10.1590/s1806-37132006000600009.

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OBJETIVO: Avaliar as características radiológicas das massas conglomeradas pela tomografia computadorizada de alta resolução de tórax. MÉTODOS: Foram selecionados 75 pacientes silicóticos, a maioria jateadores de areia, portadores de fibrose maciça progressiva, atendidos no Hospital Universitário Antônio Pedro entre 1986 e 2004. Os pacientes foram submetidos a avaliação clínica, radiografia simples de tórax e tomografia computadorizada de alta resolução. RESULTADOS: Mais da metade dos pacientes com silicose complicada mostrou na radiografia de tórax grandes opacidades dos tipos B e C, denotand
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34

Cervino, Gabriele, Luca Fiorillo, Alan Herford, et al. "Alginate Materials and Dental Impression Technique: A Current State of the Art and Application to Dental Practice." Marine Drugs 17, no. 1 (2018): 18. http://dx.doi.org/10.3390/md17010018.

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Hydrocolloids were the first elastic materials to be used in the dental field. Elastic impression materials include reversible (agar-agar), irreversible (alginate) hydrocolloids and synthetic elastomers (polysulfides, polyethers, silicones). They reproduce an imprint faithfully, providing details of a high definition despite the presence of undercuts. With the removal of the impression, being particularly rich in water, the imprints can deform but later adapt to the original shape due to the elastic properties they possess. The advantages of using alginate include the low cost, a better tolera
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35

César Santos de Castro1,2,3, Marcos, Angela Santos Ferreira Nani2, Kaio Cezar Rodrigues Salum1, et al. "Genetic polymorphisms and their effects on the severity of silicosis in workers exposed to silica in Brazil." Jornal Brasileiro de Pneumologia, September 30, 2022, e20220167. http://dx.doi.org/10.36416/1806-3756/e20220167.

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Objective: Silicosis is a pneumoconiosis characterized by fibrosis of the lung parenchyma caused by inhalation of silica particles. Genetic factors might play a role in the severity silicosis. We sought to evaluate the influence of polymorphisms in the ACE, FAS, FASLG, NOS2, IL1RN, FAM13A, TGFB1, and TNF genes on the severity of silicosis. Methods: Nine polymorphisms were genotyped by PCR in a sample of 143 patients with silicosis in the state of Rio de Janeiro, Brazil. Results: Fifty-seven patients (40%) were classified as having simple silicosis and 86 (60%) were classified as having complic
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Hoy, Ryan F., Deborah C. Glass, Christina Dimitriadis, Jessy Hansen, Fiona Hore-Lacy, and Malcolm R. Sim. "Identification of early-stage silicosis through health screening of stone benchtop industry workers in Victoria, Australia." Occupational and Environmental Medicine, October 28, 2020, oemed—2020–106897. http://dx.doi.org/10.1136/oemed-2020-106897.

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ObjectivesThe popularity of high silica content artificial stone has been associated with emergence of severe, progressive silicosis as a major health issue affecting workers in the stone benchtop industry. This population-based health assessment programme has been implemented with the aim of identifcation of silica-associated disease at a preclinical stage.MethodsAll current and former workers from the stone benchtop industry in the State of Victoria are offered free health assessments. Primary evaluations include a standardised questionnaire, physical examination, spirometry and gas transfer
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Santos de Castro1,2, Marcos César, Lucas de Carvalho Costa1, Kaio Cezar Rodrigues Salum1, et al. "Silica-exposed patients with silicosis show shorter telomeres than do unexposed individuals: a pilot study in a population in southeastern Brazil." Jornal Brasileiro de Pneumologia, December 3, 2024, e20240318. https://doi.org/10.36416/1806-3756/e20240318.

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Objective: Silicosis is a pneumoconiosis characterized by fibrosis of the lung parenchyma caused by the inhalation of silica particles. Silica dust inhalation is associated with inflammation and induction of oxidative stress in the lungs. This oxidative stress affects telomeres, which are short tandem DNA repeats that cap the end of linear chromosomes. We aimed to determine whether telomere length (TL) correlates with silicosis or severity of silicosis in silica-exposed workers in Brazil. Methods: We included 200 men in southeastern Brazil: 100 with silicosis and 100 who had not been exposed t
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Santos de Castro1,2, Marcos César, Angela Santos Ferreira Nani2, Kaio Cezar Rodrigues Salum1, et al. "A polymorphism in the FAM13A gene confers protection against tuberculosis in Brazilian workers exposed to silica." Jornal Brasileiro de Pneumologia, March 31, 2025, e20240327. https://doi.org/10.36416/1806-3756/e20240327.

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Objective: Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis, which was recognized by the World Health Organization (WHO) as a global epidemic in 1993. TB is the leading infectious disease associated with silicosis, with studies showing an increased risk when compared to healthy individuals. We conducted an association study to evaluate the influence of polymorphisms in the ACE, FAM13A, FAS, FASLG, IL1RN, NOS2, TGFB1, and TNF genes on TB susceptibility. Methods: Nine polymorphisms were genotyped using Polymerase Chain Reaction (PCR) in a sample of 143
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Hoy, Ryan F., Christina Dimitriadis, Michael Abramson, et al. "Prevalence and risk factors for silicosis among a large cohort of stone benchtop industry workers." Occupational and Environmental Medicine, June 16, 2023, oemed—2023–108892. http://dx.doi.org/10.1136/oemed-2023-108892.

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ObjectivesHigh silica content artificial stone has been found to be associated with silicosis among stone benchtop industry (SBI) workers. The objectives of this study were to determine the prevalence of and risk factors for silicosis among a large cohort of screened SBI workers, and determine the reliability of respiratory function testing (RFT) and chest x-ray (CXR) as screening tests in this industry.MethodsSubjects were recruited from a health screening programme available to all SBI workers in Victoria, Australia. Workers undertook primary screening, including an International Labour Offi
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Kumari, Jyoti, Manish Advani, and Gopal Purohit. "Prevalence of pulmonary hypertension in chronic simple silicosis patients and its correlation with smoking history, occupation type, age and duration of silica exposure." Monaldi Archives for Chest Disease, November 30, 2023. http://dx.doi.org/10.4081/monaldi.2023.2719.

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Silicosis is a preventable occupational health hazard with potential for permanent physical disability and increased socio-economic burden. Pulmonary hypertension (PH) secondary to chronic respiratory diseases signifies poorer prognosis and transthoracic echocardiography (TTE) has proven its usefulness as a screening tool for PH diagnosis. The objectives were to determine PH prevalence in chronic simple silicosis patients through TTE screening and correlate PH prevalence with smoking status, occupation type, age and duration of silica exposure (DSE). We enrolled 104 patients in the study based
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"Evaluation of Epidemiological Features and Clinical Symptoms in Patients with Silicosis Hospitalized in Educational and Medical Centers of Hamadan, Iran, From 2011 to 2021." Journal of occupational, October 9, 2024, 105–14. http://dx.doi.org/10.32592/joohe.11.2.105.

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Background and Objective: Due to the presence of many workshops related to the production of industrial silica in Hamadan province, the workers in these units are constantly exposed to the risks of inhaling crystalline silica dust. Therefore, the present study aimed to investigate the epidemiological characteristics of patients with silicosis in Hamadan province in Iran. Materials and Methods: An observational cross-sectional study was conducted on 25 patients with silicosis between 2011 and 2021. The study examined the files of all silicosis patients hospitalized in Hamadan hospitals. In this
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Sanchez‐Morillo, Daniel, Antonio León‐Jiménez, María Guerrero‐Chanivet, Gema Jiménez‐Gómez, Antonio Hidalgo‐Molina, and Antonio Campos‐Caro. "Integrating routine blood biomarkers and artificial intelligence for supporting diagnosis of silicosis in engineered stone workers." Bioengineering & Translational Medicine, June 28, 2024. http://dx.doi.org/10.1002/btm2.10694.

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AbstractEngineered stone silicosis (ESS), primarily caused by inhaling respirable crystalline silica, poses a significant occupational health risk globally. ESS has no effective treatment and presents a rapid progression from simple silicosis (SS) to progressive massive fibrosis (PMF), with respiratory failure and death. Despite the use of diagnostic methods like chest x‐rays and high‐resolution computed tomography, early detection of silicosis remains challenging. Since routine blood tests have shown promise in detecting inflammatory markers associated with the disease, this study aims to ass
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Sánchez, Morillo Daniel, Jiménez Antonio León, Chanivet María Guerrero, Gómez Gema Jiménez, Molina Antonio Hidalgo, and Caro Antonio Campos. "Integrating routine blood biomarkers and artificial intelligencefor supporting diagnosis of silicosis in engineered stoneworkers." Bioengineering & Translational Medicine, June 28, 2024, e10694. https://doi.org/10.1002/btm2.10694.

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Engineered stone silicosis (ESS), primarily caused by inhaling respirable crystalline silica, poses a significant occupational health risk globally. ESS has no effective treatment and presents a rapid progression from simple silicosis (SS) to progressive massive fibrosis (PMF), with respiratory failure and death. Despite the use of diagnostic methods like chest x-rays and high-resolution computed tomography, early detection of silicosis remains challenging. Since routine blood tests have shown promise in detecting inflammatory markers associated with the disease, this study aims to assess whet
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Shu Ann Hon, Lian Thai Lee, and Qin Jian Low. "A Case Report of Silicosis: Culprit of Progressive Massive Fibrosis." Borneo Journal of Medical Sciences (BJMS), May 31, 2021, 53. http://dx.doi.org/10.51200/bjms.vi.3149.

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Silicosis is a fibronodular lung disease secondary to the inhalation of crystalline silica dust. It had continued to cause significant morbidity and mortality worldwide. Here is a case of a 63-year-old woman, a lifelong non-smoker who complained of intermittent wheezing since retired 8 years ago. She had worked in the clay and piping industry for more than a decade. She wore only a simple 3-ply face mask at work without other protective devices. She had multiple hospital admissions for acute exacerbation of chronic lung disease for the past several years. Respiratory examinations revealed bila
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Jalutharia, Jitendra, Ramakant Dixit, Rajveer Kuldeep, Mukesh Goyal, Manisha Choudhary, and Komal Srivastava. "Six-minute walk test among silicosis patients: Its correlation with abnormal radiographic findings on chest radiograph and high resolution computed tomography scan." Annals of the National Academy of Medical Sciences (India), August 17, 2024, 1–5. http://dx.doi.org/10.25259/anams-2023-1-8-(818).

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Objectives Silicosis is one of the oldest chronic lung diseases that leads to relentless fibrotic changes in the lungs with a resultant fall in lung functions. This study was conducted to assess exercise capacity utilizing a six-minute walk test (6-MWT) among patients detected to have “simple” and “complicated” forms of silicosis. A further correlation between 6-MWT parameters and abnormal chest imaging findings was also done. Material and Methods Silicosis diagnosis among study subjects was based on the history of exposure to occupational silica dust along with suggestive radiological finding
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García-Núñez, Alejandro, Gema Jiménez-Gómez, Antonio Hidalgo-Molina, Juan Antonio Córdoba-Doña, Antonio León-Jiménez, and Antonio Campos-Caro. "Inflammatory indices obtained from routine blood tests show an inflammatory state associated with disease progression in engineered stone silicosis patients." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-11926-x.

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AbstractPatients with silicosis caused by occupational exposure to engineered stone (ES) present a rapid progression from simple silicosis (SS) to progressive massive fibrosis (PMF). Patient classification follows international rules based on radiology and high-resolution computed tomography (HRCT), but limited studies, if any, have explored biomarkers from routine clinical tests that can be used as predictors of disease status. Our objective was thus to investigate circulating biomarker levels and systemic inflammatory indices in ES silicosis patients whose exposure to ES dust ended several y
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Smărăndescu, Raluca-Andreea, Marina-Ruxandra Oțelea, Eugenia Panaitescu, Andrä Jitka, Francesco Bonella, and Agripina Rașcu. "Serum concentrations of Krebs von den Lungen-6 as prognostic biomarker in patients with silicosis." Frontiers in Medicine 12 (June 6, 2025). https://doi.org/10.3389/fmed.2025.1579209.

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IntroductionKL-6, a pneumocyte derived biomarker, is increased in patients with interstitial lung diseases (ILDs). We aimed to investigate the role of serum KL-6 as a diagnostic and prognostic biomarker in silica-exposed workers.Material and methodWe studied 108 silica-exposed subjects and 25 healthy controls. Chest radiography (CXR), pulmonary function tests, inflammatory markers were collected. Progressive massive fibrosis (PMF) was defined according to the ILO classification. KL-6 was measured in serum by fully automated CLEIA at first presentation at our institution, intended as baseline v
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Gaviola, Chelsea, Laura Nicolaou, Arun K. Sharma, et al. "Knowledge, attitudes and practices regarding respirable silica exposure and personal protective equipment use among brick kiln workers in Nepal." Occupational and Environmental Medicine, July 2, 2024, oemed—2024–109516. http://dx.doi.org/10.1136/oemed-2024-109516.

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ObjectivesBrick kiln workers in Nepal are a neglected population who are exposed to high respirable silica concentrations, and few use interventions to reduce exposure. We aimed to characterise the prevalence of respiratory personal protective equipment (PPE) use, understand knowledge and attitudes towards kiln dust and respiratory PPE and identify factors associated with respiratory PPE use.MethodsWe conducted a cross-sectional study in Bhaktapur, Nepal. We used simple random selection to identify 10 out of 64 total kilns and stratified random sampling of 30 households to enrol workers aged ≥
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Ozog, P., H. Elsayed, L. Grigolato, et al. "Engineering of silicone-based blends for the masked stereolithography of biosilicate/carbon composite scaffolds." Journal of the European Ceramic Society 42 (2022) 6192–6198 (October 27, 2022). https://doi.org/10.1016/j.jeurceramsoc.2022.06.057.

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Silicone resins, filled with phosphates and other oxide fillers, have been recently proposed as feedstock for the manufacturing of scaffolds with a composition resembling that of commercial Biosilicate&reg; glass-ceramics. Silicones and engineered fillers enable the preparation of novel carbon-containing Biosilicate-based composites and, fundamentally, the easy application of additive manufacturing technologies. After successful demonstration of the applicability of direct ink writing of silicone-based pastes, the present paper is dedicated to preparation of highly porous scaffolds obtained by
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Zhao, Guoxu, Tinglong Wu, Ruhai Wang, et al. "Hydrogel-assisted microfluidic spinning of stretchable fibers via fluidic and interfacial self-adaptations." Science Advances 9, no. 42 (2023). http://dx.doi.org/10.1126/sciadv.adj5407.

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Stretchable polymeric fibers have enormous potential, but their production requires rigorous environmental controls and considerable resource consumption. It's also challenging for elastic polymers with high performance but poor spinnability, such as silicones like polydimethylsiloxane and Ecoflex. We present a hydrogel-assisted microfluidic spinning (HAMS) method to address these challenges by encapsulating their prepolymers within arbitrarily long, protective, and sacrificable hydrogel fibers. By designing simple apparatuses and manipulating the fluidic and interfacial self-adaptations of oi
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