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Journal articles on the topic 'Simulated moving bed (SMB)'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Song, Sung-Moon, and In-Ho Kim. "Simulation of IgY(Immunoglobulin Yolk) Purification by SMB(Simulated Moving Bed)." Korean Chemical Engineering Research 49, no. 6 (December 1, 2011): 798–803. http://dx.doi.org/10.9713/kcer.2011.49.6.798.

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2

Silva, Eduardo Alberto Borges da, Antônio Augusto Ulson de Souza, Alírio Egídio Rodrigues, and Selene Maria Arruda Guelli Ulson de Souza. "Glucose isomerization in simulated moving bed reactor by Glucose isomerase." Brazilian Archives of Biology and Technology 49, no. 3 (May 2006): 491–502. http://dx.doi.org/10.1590/s1516-89132006000400018.

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Studies were carried out on the production of high-fructose syrup by Simulated Moving Bed (SMB) technology. A mathematical model and numerical methodology were used to predict the behavior and performance of the simulated moving bed reactors and to verify some important aspects for application of this technology in the isomerization process. The developed algorithm used the strategy that considered equivalences between simulated moving bed reactors and true moving bed reactors. The kinetic parameters of the enzymatic reaction were obtained experimentally using discontinuous reactors by the Lineweaver-Burk technique. Mass transfer effects in the reaction conversion using the immobilized enzyme glucose isomerase were investigated. In the SMB reactive system, the operational variable flow rate of feed stream was evaluated to determine its influence on system performance. Results showed that there were some flow rate values at which greater purities could be obtained.

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3

Yun, Sang-Hee, and In-Ho Kim. "Comparative Simulation of 3-zone SMB (Simulated Moving Bed) and 4-zone SMB for IgY (Immunoglobulin Yolk) Purification." Korean Chemical Engineering Research 50, no. 5 (October 1, 2012): 866–73. http://dx.doi.org/10.9713/kcer.2012.50.5.866.

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4

Li, Liangyu, Wanxia Liu, Dawei Song, Chaoyang Li, Pengyu Jia, and Guagcai Niu. "Simulated Moving Bed Purification for Flavonoids from Tartary Buckwheat Shell." Journal of Chromatographic Science 58, no. 4 (March 12, 2020): 362–72. http://dx.doi.org/10.1093/chromsci/bmz122.

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Abstract Tartary buckwheat shell is an important by-product of Tartary buckwheat production. Previous studies shown that Tartary buckwheat shells are rich in flavonoids, which are responsible for their antioxidant properties. Due to lack of advanced separation technologies, the purification for Tartary buckwheat shell is still in the laboratory scale, and could not realize the industrialization production. According to the results of static adsorption experiment, AB-8 resin was selected for Tartary buckwheat shell flavonoids (TBSF) adsorption. The adsorption isotherm, resin adsorption thermodynamic and dynamic adsorption parameters were studied. And the adsorption of AB-8 resin for TBSF was determined as an endothermic process. Results of preparative chromatography experiment showed that TBSF could be efficiently purified by AB-8 resin. And the optimal parameters were: feed concentration 25 mg/mL, desorption flow rate 2.5 mL/min. Under these conditions, the TBSF were separated effectively. Results of liquid chromatography-mass spectrometer (LC-MS) indicated that there were seven kinds of flavonoids in Tartary buckwheat shell, which were mainly from the 40 and 60% of ethanol elution. Simulated moving bed (SMB) was applied for TBSF purification the first time in this study. The optimal conditions of SMB were as following: adsorption zone flow rate 7.0 mL/min, contaminant removal zone flow rate 17.9 mL/min, product elution zone flow rate 22.3 mL/min, regeneration zone flow rate 21.5 mL/min, water washing zone flow rate 27.5 mL/min, switching time 1260 S, and the purity and yield of TBSF was 90 ± 0.22% and 85 ± 0.28%, respectively. The IC50 values of α-glucosidase inhibition activities and DPPH scavenging activity of the purified TBSF were 57.09 ± 0.15 and 7.92 ± 0.23 μg/mL, respectively. The constituents of TBSF showed higher α-glucosidase inhibition activities and antioxidant than raw TBSF and rutin. The results suggest that SMB is a proper method for industrial production of TBSF, and SMB could be applied for other natural products purification.

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5

Song, Jae-Ryong, Jin-Il Kim, and Yoon-Mo Koo. "Principles of Simulated Moving Bed Reactor(SMBR)." Korean Chemical Engineering Research 49, no. 2 (April 30, 2011): 129–36. http://dx.doi.org/10.9713/kcer.2011.49.2.129.

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6

Yan, Zhen, Jie-Sheng Wang, Shao-Yan Wang, Shou-Jiang Li, Dan Wang, and Wei-Zhen Sun. "Model Predictive Control Method of Simulated Moving Bed Chromatographic Separation Process Based on Subspace System Identification." Mathematical Problems in Engineering 2019 (October 22, 2019): 1–24. http://dx.doi.org/10.1155/2019/2391891.

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Simulated moving bed (SMB) chromatographic separation is a new type of separation technology based on traditional fixed bed adsorption operation and true moving bed (TMB) chromatographic separation technology, which includes inlet-outlet liquid, liquid circulation, and feed liquid separation. The input-output data matrices were constructed based on SMB chromatographic separation process data. The SMB chromatographic separation process was modeled by utilizing two subspace system identification algorithms: multivariable output-error state-space (MOESP) identification algorithm and numerical algorithms for subspace state-space system identification (N4SID), so as to obtain the 3rd-order and 4th-order state-space yield models of the SMB chromatographic separation process, respectively. The model predictive control method based on the established state-space models is used in the SMB chromatographic separation process. The influence of different control indicators on the predictive control system response performance is discussed. The output response curves of the yield models were obtained by changing the related parameters so that the yield model parameters are optimized set meanwhile. Finally, the simulation results showed that the yield models are successfully controlled based on the each control period and given yield range.

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7

Wiśniewski, Łukasz, Monika Antošová, and Milan Polakovič. "Simulated moving bed chromatography separation of galacto-oligosaccharides." Acta Chimica Slovaca 6, no. 2 (October 1, 2013): 206–10. http://dx.doi.org/10.2478/acs-2013-0033.

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Abstract A mixture of galacto-oligosaccharides and non-prebiotic sugars was separated using a simulated moving bed unit equipped with eight packed-bed columns of a cation exchanger. In order to determine operating conditions using triangle theory, equilibrium adsorption isotherms of galactose, glucose, lactose, tri- and tetragalacto-oligosaccharide were measured. It was found that each column of the SMB unit had a maximum separation efficiency of more than 3000 theoretical plates. The achieved purity of galacto-oligosaccharides in the raffinate stream was 99.9 %, similarly 99.9 % of extract was formed by non-prebiotic sugars lactose, glucose and galactose. The productivities in the raffinate and extract, were 0.6 g/(L h) and 2.4 g/(L h), respectively.

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8

Hur, Jin Seok, and Phillip C. Wankat. "New Design of Simulated Moving Bed (SMB) for Ternary Separations." Industrial & Engineering Chemistry Research 44, no. 6 (March 2005): 1906–13. http://dx.doi.org/10.1021/ie040164e.

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9

Denet, Félicie, Willy Hauck, Roger Marc Nicoud, Orazio Di Giovanni, Marco Mazzotti, Jean Noël Jaubert, and Massimo Morbidelli. "Enantioseparation through Supercritical Fluid Simulated Moving Bed (SF-SMB) Chromatography." Industrial & Engineering Chemistry Research 40, no. 21 (October 2001): 4603–9. http://dx.doi.org/10.1021/ie000959v.

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10

Kim, Jin-Il, and Yoon-Mo Koo. "Process modification of SMB (Simulated Moving Bed) for multicomponent separation." Journal of Bioscience and Bioengineering 108 (November 2009): S57. http://dx.doi.org/10.1016/j.jbiosc.2009.08.167.

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11

Schmidt-Traub, Henner, Jochen Strube, Hanns-Ingolf Paul, and Stefan Michel. "Dynamische Simulation des kontinuierlichen SMB (Simulated Moving Bed)-Chromatographie-Prozesses." Chemie Ingenieur Technik 67, no. 3 (March 1995): 323–26. http://dx.doi.org/10.1002/cite.330670311.

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12

Kim, In Ho, and Sung Moon Song. "Simulated Moving Bed(SMB) Chromatography Simulation for Loxoprofen Racemates Separation." Korean Chemical Engineering Research 49, no. 5 (October 1, 2011): 623–27. http://dx.doi.org/10.9713/kcer.2011.49.5.623.

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13

Cremasco, Marco Aurelio, and Axel Nicolas Starqui. "Modeling for Taxol® Separation in a simulated moving bed." Brazilian Archives of Biology and Technology 53, no. 6 (December 2010): 1433–41. http://dx.doi.org/10.1590/s1516-89132010000600020.

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This work presents an alternative numerical resolution strategy for a model to describe the dynamic of linear adsorption processes involving multicomponent mixture of taxanes with Taxol® (paclitaxel), a powerful anti-cancer agent, and non-identified impurities, in a Simulated Moving Bed (SMB) system. To solve the model, a hybrid method were used. The liquid concentration inside the particles was found analytically and was related with the liquid bed concentration using Duhamel's theorem. The results from simulation were compared with experimental ones from the literature, showing a good agreement, which demonstrated the applicability of the model and of the hybrid resolution proposed.

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14

Li, Liangyu, Cheng Luo, and Xiqun Zheng. "Purification of Anthocyanins Derived from Black Kidney Bean (Phaseolus vulgaris L.) by a Simulated Moving Bed." Journal of Chemistry 2021 (June 16, 2021): 1–12. http://dx.doi.org/10.1155/2021/5580756.

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Purification of anthocyanins derived from black kidney bean (Phaseolus vulgaris L.) by column chromatography and simulated moving bed (SMB) methods was investigated, and the anthocyanins of black kidney bean were identified. The SMB had advantages over column chromatography in processing efficiency, operation cost, and automation degree in contrast testing. The best SMB conditions resulted in purity and yield of black kidney bean anthocyanins of 24.61 ± 0.21% and 87.85 ± 0.32%, respectively. The half maximal inhibitory concentration (IC50) of 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity and 2,2ʹ-azinobis-(3-ethylbenzthiazoline-6-sulphonate) radical (ABTS+∙) scavenging activity was 0.95 and 2.14 of refined anthocyanins, respectively, indicating strong antioxidant capacity. Three anthocyanins were detected and identified by UPLC-Triple-TOF/MS from black kidney bean skins: delphinidin-3-O-glucoside, petunidin-3-O-glucoside, and malvidin-3-O-glucoside. The experimental results suggested that SMB may help promote industrialization and purification of anthocyanins from colored kidney beans as well as from other plant materials.

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15

Dong, Tai Thi Ngoc, Chih-Hsiung Lin, and Ming-Tsai Liang. "The Application of Simulated Moving-Bed Chromatography for the Separation of Ginsenosides in Sanchi Ginseng and American Ginseng." Natural Product Communications 15, no. 10 (October 2020): 1934578X2096467. http://dx.doi.org/10.1177/1934578x20964671.

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In this study, the separation of ginsenosides from the crude extract of Sanchi ginseng and American ginseng, obtained by aqueous ethanol extraction, was conducted in a simulated moving bed (SMB) with cleaning in place (CIP) design. Concentrated products with 86.2%, w/w, and 91.5%, w/w, of ginsenosides were obtained by the utilization of CIP-SMB for Sanchi and American ginseng, respectively. This study reveals that CIP-SMB could enrich ginsenosides by removing the retained impurities, which were initially extracted by aqueous ethanol and not removed by either the antisolvent precipitation for Sanchi ginseng or the ethyl acetate extraction for American ginseng. Although the ginsenosides in both ginsengs are similar, the difficulty in applying chromatography to the crude extract differs. A natural crude extract normally contains compounds with significant difference in retention. A traditional SMB with 4 sections will be, consequently, unable to continuously separate the natural products. This study develops methods for pretreating the crude extract and demonstrates the feasibility of continuously separating ginsenosides by using SMB. SMB is an effective technology for large-scale chromatography and can generally resolve solvent and energy consumption problems. This is expected to promote the industrial use of SMB for the production of concentrated ginsenosides as active pharmaceutical ingredients.

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16

Schulte, Michael, Nadine Lühring, Andreas Keil, and Yogesh S. Sanghvi. "Purification of DMT-On Oligonucleotide by Simulated Moving-Bed (SMB) Chromatography." Organic Process Research & Development 9, no. 2 (March 2005): 212–15. http://dx.doi.org/10.1021/op050006e.

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17

García, María-Sonia G., Eva Balsa-Canto, Julio R. Banga, and Alain Vande Wouwer. "Dynamic Optimization of a Simulated Moving Bed (SMB) Chromatographic Separation Process." Industrial & Engineering Chemistry Research 45, no. 26 (December 2006): 9033–41. http://dx.doi.org/10.1021/ie060576i.

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18

Palani, S., G. Jayaraman, L. Gueorguieva, U. Rinas, and A. Seidel-Morgenstern. "Kontinuierliche Aufreinigung der rekombinanten Streptokinase mittels Simulated Moving Bed (SMB)-Chromatographie." Chemie Ingenieur Technik 81, no. 8 (August 2009): 1291. http://dx.doi.org/10.1002/cite.200950582.

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19

García, María-Sonia G., Eva Balsa-Canto, Alain Vande Wouwer, and Julio R. Banga. "OPTIMAL CONTROL of the SIMULATED MOVING BED (SMB) CHROMATOGRAPHIC SEPARATION PROCESS." IFAC Proceedings Volumes 40, no. 5 (2007): 183–88. http://dx.doi.org/10.3182/20070606-3-mx-2915.00029.

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20

Meurer, M., U. Altenhöner, J. Strube, and H. Schmidt-Traub. "44. Entwurf und Auslegung kontinuierlicher Simulated-moving-bed-(SMB)-Chromatographie-Reaktoren." Chemie Ingenieur Technik 68, no. 9 (September 1996): 1092. http://dx.doi.org/10.1002/cite.330680946.

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21

Kim, Tae Ho, Kwan Young Ko, and In Ho Kim. "Simulation of D-limonene Separation from Mandarine Extract in Simulated Moving Bed (SMB)." Korean Chemical Engineering Research 54, no. 1 (February 1, 2016): 81–88. http://dx.doi.org/10.9713/kcer.2016.54.1.81.

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22

Shahmoradi, Ali, Mohammad Reza Khosravi-Nikou, Masoud Aghajani, Ahmad Shariati, and Shahram Saadi. "Mathematical modeling and optimization of industrial scale ELUXYL simulated moving bed (SMB)." Separation and Purification Technology 248 (October 2020): 116961. http://dx.doi.org/10.1016/j.seppur.2020.116961.

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23

Song, Sung-Moon, Moon-Bae Park, and In Ho Kim. "Three-zone simulated moving-bed (SMB) for separation of cytosine and guanine." Korean Journal of Chemical Engineering 29, no. 7 (January 25, 2012): 952–58. http://dx.doi.org/10.1007/s11814-011-0247-6.

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24

Lee, Il Song, In Su Lee, and In Ho Kim. "Simulation of (R)- and (S)- Ketoprofen Separation in Simulated Moving Bed (SMB)." KSBB Journal 29, no. 4 (August 31, 2014): 250–62. http://dx.doi.org/10.7841/ksbbj.2014.29.4.250.

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25

Fang, Ying Ying, Xiao Ling Zha, Hui Li, and Wei Fang Yu. "Determination of Henry Constants of Azelnidipine Enantiomers on Chiralpak AD Column at Different Temperatures." Advanced Materials Research 1078 (December 2014): 78–81. http://dx.doi.org/10.4028/www.scientific.net/amr.1078.78.

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Simulated moving bed (SMB) chromatographic separation has become a highly promising method for chiral separation due to the less solvent consumption and efficient utilization of stationary phase. As reported, Azelnidipine exists two isomeric forms, it is necessary to product azelnidipine single enantiomer for medical safety and drug developmen. However, the separation of azelnidipine enantiomers on SMB is complex, requiring many operating parameters. And the SMB processes with temperature gradient (non-isotherm) mode may have significant advantages over the traditional isothermal mode. In this article, the Henry constants of azelnidipine enantiomers were determined with pulse experiments on Chiralpak AD column at different temperatures. It provided important references for the production of azelnidipine single enantiomer with non-isotherm SMB.

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26

Liang, Ming Tsai, Ru Chien Liang, Shu Qi Yu, Ri An Yan, and Ku Yuan Liang. "Supercritical Fluid Extraction of Polygonum cuspidatum and Subsequent Isolation by Simulated Moving Bed Chromatography." Advanced Materials Research 704 (June 2013): 18–30. http://dx.doi.org/10.4028/www.scientific.net/amr.704.18.

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In this work, supercritical carbon dioxide with ethanol as cosolvent was employed to extract bioactive compounds fromPolygonum Cuspidatum. Effect of temperature for 40 and 50 C on the extraction at 35 MPa was examined. It was found that extraction at 50 C resulted in high yield. A two-stage extraction at 50 C and 35 MPa was then designed to investigate effect of cosolvent on the recovery of resveratrol and emodin. The first stage extraction by solely using carbon dioxide can rarely extract resveratrol, but adding ethanol as cosolvent in the second stage significantly increases the extraction of resverarol and emodin. The crude extract obtained in the second stage was very stable against agglomeration and precipitation, because the first stage extraction helped to remove impurities from thePolygonum Cuspidatum. The stable crude extract was subsequently used as the feed for the SMB (simulated moving bed) separation. In this work, experimental validation was completed by solely using single SMB to isolate resveratrol, emodin, and physcion from the crude extract. As conducting the SMB experiments, the Triangle theory was used to help to determine the separable operating conditions. From the discussion of the experimental results, the criterion to obtain the pure resveratrol and physcion, and the concentrated emodin were depicted. Since both the extraction and the purification are conducted at low temperature, the bioactivity of the produced natural products will totally be preserved. The two-stage extraction and subsequent purification in this paper will provide greener and effective alternative for the development of botanical drugs.

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27

Yang, Yiwen, Yehui Wang, Zongbi Bao, Qiwei Yang, Zhiguo Zhang, and Qilong Ren. "Progress in the Enantioseparation of β-Blockers by Chromatographic Methods." Molecules 26, no. 2 (January 17, 2021): 468. http://dx.doi.org/10.3390/molecules26020468.

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β-adrenergic antagonists (β-blockers) with at least one chiral center are an exceedingly important class of drugs used mostly to treat cardiovascular diseases. At least 70 β-blockers have been investigated in history. However, only a few β-blockers, e.g., timolol, are clinically marketed as an optically pure enantiomer. Therefore, the separation of racemates of β-blockers is essential both in the laboratory and industry. Many approaches have been explored to obtain the single enantiomeric β-blocker, including high performance liquid chromatography, supercritical fluid chromatography and simulated moving bed chromatography. In this article, a review is presented on different chromatographic methods applied for the enantioseparation of β-blockers, covering high performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC) and simulated moving bed chromatography (SMB).

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28

Paredes, Galatea, Stefanie Abel, Marco Mazzotti, Massimo Morbidelli, and Joachim Stadler. "Analysis of a Simulated Moving Bed Operation for Three-Fraction Separations (3F-SMB)." Industrial & Engineering Chemistry Research 43, no. 19 (September 2004): 6157–67. http://dx.doi.org/10.1021/ie0498293.

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29

Bihain, Anderson Luis Jeske, Pedro Castro Menezes Xavier de Mello e Silva, Everton Mendes de Oliveira, Leandro Blass, Antônio José da Silva Neto, and Leôncio Diógenes Tavares Câmara. "Inverse Stochastic Routine Combined to a Stepwise Modeling Approach in the Chromatographic Column Characterization Applied to Simulated Moving Bed-SMB Separation of Verapamil Enantiomers." Defect and Diffusion Forum 372 (March 2017): 101–9. http://dx.doi.org/10.4028/www.scientific.net/ddf.372.101.

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Simulated Moving Bed (SMB) chromatographic processes for the enantiomers separation of the drug verapamil were evaluated through stepwise modeling approach. Predictions of the model were compared to the dispersive equilibrium model in the simulation of continuous separation process and validated with data taken for both compounds in a SMB experimental set-up. An inverse problem tool was associated to the chromatographic columns aiming at their characterization through the global mass transfer parameters using only the experimental residence times of each enantiomer. According to the study conducted, the proposed approach was shown to be a tool with a good potential to predict the chromatographic behavior of a sample in a test pulse, as well as the simulation of separation of a compound in SMB equipment despite minor discrepancies presented in the first work cycles of the SMB. Moreover, the approach can be easily implemented and applied in the analysis of the process.

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30

Paredes, Galatea, Hyun-Ku Rhee, and Marco Mazzotti. "Design of Simulated-Moving-Bed Chromatography with Enriched Extract Operation (EE-SMB): Langmuir Isotherms." Industrial & Engineering Chemistry Research 45, no. 18 (August 2006): 6289–301. http://dx.doi.org/10.1021/ie060256z.

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31

Zerrougui, Mohamed, Boulaid Boulkroune, and Michel Kinnaert. "Fault detection and isolation of concentration sensors in simulated moving bed chromatographic processes (SMB)." IFAC Proceedings Volumes 46, no. 26 (2013): 177–84. http://dx.doi.org/10.3182/20130925-3-fr-4043.00063.

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32

Borges da Silva, E. A., A. A. Ulson de Souza, and S. M. A. Guelli U. Souza. "The use of simulated moving bed in chromatographic separation: study of the SMB configuration." Separation Science and Technology 37, no. 7 (May 28, 2002): 1489–504. http://dx.doi.org/10.1081/ss-120002733.

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33

Deveant, Ralf M., Rochus Jonas, Michael Schulte, Andreas Keil, and Frederic Charton. "Enantiomer Separation of a Novel Ca-Sensitizing Drug by simulated moving bed (SMB) - chromatography." Journal für Praktische Chemie/Chemiker-Zeitung 339, no. 1 (1997): 315–21. http://dx.doi.org/10.1002/prac.19973390159.

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34

Yoon, Tae Ho, Bong Hyun Chung, and In Ho Kim. "A novel design of simulated moving bed (SMB) chromatography for separation of ketoprofen enantiomer." Biotechnology and Bioprocess Engineering 9, no. 4 (August 2004): 285–91. http://dx.doi.org/10.1007/bf02942345.

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35

Wang, Dan, Jie-Sheng Wang, Shao-Yan Wang, Shou-Jiang Li, Zhen Yan, and Wei-Zhen Sun. "Soft Sensing Modeling of the SMB Chromatographic Separation Process Based on the Adaptive Neural Fuzzy Inference System." Journal of Sensors 2019 (November 13, 2019): 1–16. http://dx.doi.org/10.1155/2019/1312709.

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Simulated moving bed (SMB) chromatographic separation technology is a new adsorption separation technology with strong separation ability. Based on the principle of the adaptive neural fuzzy inference system (ANFIS), a soft sensing modeling method was proposed for realizing the prediction of the purity of the extract and raffinate components in the SMB chromatographic separation process. The input data space of the established soft sensor model is divided, and the premise parameters are determined by utilizing the meshing partition method, subtractive clustering algorithm, and fuzzy C-means (FCM) clustering algorithm. The gradient, Kalman, Kaczmarz, and PseudoInv algorithms were used to optimize the conclusion parameters of ANFIS soft sensor models so as to predict the purity of the extract and raffinate components in the SMB chromatographic separation process. The simulation results indicate that the proposed ANFIS soft sensor models can effectively predict the key economic and technical indicators of the SMB chromatographic separation process.

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36

Harriehausen, Isabel, Katarzyna Wrzosek, Heike Lorenz, and Andreas Seidel-Morgenstern. "Assessment of process configurations to combine enantioselective chromatography with enzymatic racemization." Adsorption 26, no. 7 (May 7, 2020): 1199–213. http://dx.doi.org/10.1007/s10450-020-00231-6.

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Abstract Enantioselective chromatography is nowadays a reliable tool for single enantiomer production from a racemate. The recovery of the distomer by racemization and recycling is a promising method to tackle the 50% yield constraint and to increase the productivity. In this paper three process configurations are compared. The production of enantiopure mandelic acid and methionine enantiomers exploiting different enzymes for racemization are evaluated as part of different chromatographic process configurations. First, the benefits of conventional simulated moving bed (SMB) chromatography in contrast to a single column batch separation unit are assessed in integrated configurations. Then, a concept of coupling the racemization with a simpler three-zone SMB unit, where one regeneration zone is removed, is evaluated.

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37

Wen, Haichao, Hui Cui, Hehe Tian, Xiaoxu Zhang, Liyan Ma, Charles Ramassamy, and Jingming Li. "Isolation of Neuroprotective Anthocyanins from Black Chokeberry (Aronia melanocarpa) against Amyloid-β-Induced Cognitive Impairment." Foods 10, no. 1 (December 29, 2020): 63. http://dx.doi.org/10.3390/foods10010063.

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Black chokeberry (Aronia melanocarpa) fruits are rich in anthocyanins, which are vital secondary metabolites that possess antioxidative properties. The aim of this study was to isolate and purify the anthocyanins from black chokeberry by simulated moving bed (SMB) chromatography, and to investigate the neuroprotective effect of SMB purified anthocyanin against Aβ-induced memory damage in rats. The parameters of the SMB process were studied and optimized. Anthocyanin extracts were identified by HPLC and UPLC-QTOF-MS, and antioxidant abilities were evaluated. The Aβ-induced animal model was established by intracerebral ventricle injection in rat brain. Through the SMB purification, anthocyanins were purified to 85%; cyanidin 3-O-galactoside and cyanidin 3-O-arabinoside were identified as the main anthocyanins by UPLC-QTOF-MS. The SMB purified anthocyanins exhibited higher DPPH and ABTS free radical scavenging abilities than the crude anthocyanins extract. Furthermore, rats receiving SMB purified anthocyanins treatment (50 mg/kg) showed improved spatial memory in a Morris water maze test, as well as protection of the cells in the hippocampus against Aβ toxicity. These results demonstrate that anthocyanins could serve as antioxidant and neuroprotective agents, with potential in the treatment of Alzheimer’s disease.

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38

Lim, Young-Il, and Sten Bay Jorgensen. "A fast and accurate numerical method for solving simulated moving bed (SMB) chromatographic separation problems." Chemical Engineering Science 59, no. 10 (May 2004): 1931–47. http://dx.doi.org/10.1016/j.ces.2003.12.026.

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39

Mestmäcker, Fabian, Axel Schmidt, Maximilian Huter, Maximilian Sixt, and Jochen Strube. "Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part III: Chromatographic Purification." Processes 6, no. 10 (October 2, 2018): 180. http://dx.doi.org/10.3390/pr6100180.

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In this study, the purification of an extract from Artemisia annua L. using chromatographic methods is studied. In a first step, a screening of different phases and solvents using thin-layer chromatography (TLC) was performed. Then, a laboratory-scale high performance liquid chromatography (HPLC) method was developed and transferred to a pilot scale. A reproducibility study based on 120 injections was carried out. The batch process that was developed and the results from a designed continuous simulated moving bed (SMB) chromatography were compared based on characteristic process numbers and economy.

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40

Kostroski, Kyle P., and Phillip C. Wankat. "Separation of Dilute Binary Gases by Simulated-Moving Bed with Pressure-Swing Assist: SMB/PSA Processes." Industrial & Engineering Chemistry Research 47, no. 9 (May 2008): 3138–49. http://dx.doi.org/10.1021/ie071000b.

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Câmara, L. D. T. "Modifier mass transfer kinetic effect in the performance of solvent gradient simulated moving bed (SG-SMB) process." Journal of Physics: Conference Series 633 (September 21, 2015): 012104. http://dx.doi.org/10.1088/1742-6596/633/1/012104.

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42

Park, Tae Hyun, Tae Ho Yoon, and In Ho Kim. "Simplistic determination of operation parameters for simulated moving bed (SMB) chromatography for the separation of ketoprofen enantiomer." Biotechnology and Bioprocess Engineering 10, no. 4 (August 2005): 341–45. http://dx.doi.org/10.1007/bf02931852.

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43

Faruque Hasan, M. M., Eric L. First, and Christodoulos A. Floudas. "Discovery of novel zeolites and multi-zeolite processes for p-xylene separation using simulated moving bed (SMB) chromatography." Chemical Engineering Science 159 (February 2017): 3–17. http://dx.doi.org/10.1016/j.ces.2016.10.039.

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44

Kim, Jin-Il, Philip C. Wankat, Sunyong Mun, and Yoon-Mo Koo. "Analysis of “focusing” effect in four-zone SMB (Simulated Moving Bed) unit for separation of xylose and glucose from biomass hydrolysate." Journal of Bioscience and Bioengineering 108 (November 2009): S65—S66. http://dx.doi.org/10.1016/j.jbiosc.2009.08.194.

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Esteves, I. A. A. C., G. M. R. P. L. Sousa, R. J. S. Silva, R. P. P. L. Ribeiro, M. F. J. Eusébio, and J. P. B. Mota. "A Sensitive Method Approach for Chromatographic Analysis of Gas Streams in Separation Processes Based on Columns Packed with an Adsorbent Material." Advances in Materials Science and Engineering 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/3216267.

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Abstract:

A sensitive method was developed and experimentally validated for the in-line analysis and quantification of gaseous feed and product streams of separation processes under research and development based on column chromatography. The analysis uses a specific mass spectrometry method coupled to engineering processes, such as Pressure Swing Adsorption (PSA) and Simulated Moving Bed (SMB), which are examples of popular continuous separation technologies that can be used in applications such as natural gas and biogas purifications or carbon dioxide sequestration. These processes employ column adsorption equilibria on adsorbent materials, thus requiring real-time gas stream composition quantification. For this assay, an internal standard is assumed and a single-point calibration is used in a simple mixture-specific algorithm. The accuracy of the method was found to be between 0.01% and 0.25% (-mol) for mixtures of CO2, CH4, and N2, tested as case-studies. This makes the method feasible for streams with quality control levels that can be used as a standard monitoring and analyzing procedure.

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Chernev, Valentin Plamenov, Alain Vande Wouwer, and Achim Kienle. "Efficient Simulation of Chromatographic Processes Using the Conservation Element/Solution Element Method." Processes 8, no. 10 (October 20, 2020): 1316. http://dx.doi.org/10.3390/pr8101316.

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Abstract:

Chromatographic separation processes need efficient simulation methods, especially for nonlinear adsorption isotherms such as the Langmuir isotherms which imply the formation of concentration shocks. The focus of this paper is on the space–time conservation element/solution element (CE/SE) method. This is an explicit method for the solution of systems of partial differential equations. Numerical stability of this method is guaranteed when the Courant–Friedrichs–Lewy condition is satisfied. To investigate the accuracy and efficiency of this method, it is compared with the classical cell model, which corresponds to a first-order finite volume discretization using a method of lines approach (MOL). The evaluation is done for different models, including the ideal equilibrium model and a mass transfer model for different adsorption isotherms—including linear and nonlinear Langmuir isotherms—and for different chromatographic processes from single-column operation to more sophisticated simulated moving bed (SMB) processes for the separation of binary and ternary mixtures. The results clearly show that CE/SE outperforms MOL in terms of computational times for all considered cases, ranging from 11-fold for the case with linear isotherm to 350-fold for the most complicated case with ternary center-cut eight-zone SMB with Langmuir isotherms, and it could be successfully applied for the optimization and control studies of such processes.

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Chin, Chim Yong, and Nien‐Hwa Linda Wang. "Simulated Moving Bed Equipment Designs." Separation & Purification Reviews 33, no. 2 (January 12, 2004): 77–155. http://dx.doi.org/10.1081/spm-200042081.

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Lee, Ju Weon, and Phillip C. Wankat. "Thermal simulated moving bed concentrator." Chemical Engineering Journal 166, no. 2 (January 2011): 511–22. http://dx.doi.org/10.1016/j.cej.2010.11.009.

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Kim, Kyung-Min, and Chang-Ha Lee. "Backfill-simulated moving bed operation for improving the separation performance of simulated moving bed chromatography." Journal of Chromatography A 1311 (October 2013): 79–89. http://dx.doi.org/10.1016/j.chroma.2013.08.058.

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Migliorini, Cristiano, Martin Fillinger, Marco Mazzotti, and Massimo Morbidelli. "Analysis of simulated moving-bed reactors." Chemical Engineering Science 54, no. 13-14 (July 1999): 2475–80. http://dx.doi.org/10.1016/s0009-2509(98)00487-4.

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