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Relevant bibliographies by topics / Single cell quantification / Dissertations / Theses

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Dissertations / Theses on the topic 'Single cell quantification'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

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1

Zheng, Yannan Ph D. Massachusetts Institute of Technology. "Quantification of microRNA regulation and its consequences at the single cell level." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/99283.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Physics, 2015.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>MicroRNAs (miRNAs) are a class of small non-coding RNAs which play important roles in post transcriptional gene regulation. miRNAs regulate more than half of mammalian protein-coding genes. They have been found to participate in almost every cellular process and their dysregulation is associated with many diseases. miRNAs recognize their targets by base paring to miRNA response elements (MREs), which are predominantly located at

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2

Stephan, Jürgen Verfasser], and Joachim [Akademischer Betreuer] [Rädler. "Cells on grids of nanostructures : From single cell distortion quantification to cell ensemble toxicity assays / Jürgen Stephan ; Betreuer: Joachim Rädler." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1183572204/34.

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3

Stephan, Jürgen [Verfasser], and Joachim [Akademischer Betreuer] Rädler. "Cells on grids of nanostructures : From single cell distortion quantification to cell ensemble toxicity assays / Jürgen Stephan ; Betreuer: Joachim Rädler." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1183572204/34.

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4

Fujita, Naotaka. "Noninvasive longitudinal quantification of β-cell mass with [111In]-labeled exendin-4". Doctoral thesis, Kyoto University, 2020. http://hdl.handle.net/2433/245834.

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京都大学<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第22149号<br>医博第4540号<br>新制||医||1039(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)教授川口義弥, 教授上本伸二, 教授富樫かおり<br>学位規則第4条第1項該当<br>Doctor of Medical Science<br>Kyoto University<br>DFAM

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5

Billman, Martin Rafael. "Quantification of HTLV-1 expression at the single-cell level in naturally-infected T-lymphocytes." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/59040.

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The human leukaemia virus HTLV-1 expresses essential accessory genes that manipulate the expression, splicing and transport of viral mRNAs. Two of these genes, tax and hbz, also promote proliferation of the infected cell, and both genes are thought to contribute to oncogenesis in adult T-cell leukaemia/lymphoma. The regulation of HTLV-1 proviral latency is not understood. tax, on the proviral plus strand, is usually silent in freshly-isolated cells, whereas the minus-strand-encoded hbz gene is persistently expressed at a low level. However, the persistently activated host immune response to Ta

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6

Steffen, Patrick [Verfasser], and Christian [Akademischer Betreuer] Wagner. "Quantification of red blood cell adhesion using holographic optical tweezers and single cell force spectroscopy / Patrick Steffen. Betreuer: Christian Wagner." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2012. http://d-nb.info/1052551068/34.

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7

Rabl, Thomas. "Spontaneous Raman spectroscopy : exploring applicability in drug discovery and the medical sciences." Thesis, University of Dundee, 2018. https://discovery.dundee.ac.uk/en/studentTheses/dc910052-a06c-4cd2-b741-0feb254c6b9b.

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This thesis reports the investigation of spontaneous Raman Spectroscopy (RS) for its applicability in early drug discovery. A key focus has been to develop an understanding of the applicability of RS for the quantification and localisation of compound concentration inside mammalian cells. Further investigation into the use of Surface Enhanced Raman Spectroscopy (SERS) for research on Visceral Leishmaniasis (VL) and Leishmania donovani as well as investigating applicability for cancer research are decisive parts of this work. The key work described in this thesis is the investigation of whole c

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8

Schwarzfischer, Michael [Verfasser], Fabian J. [Akademischer Betreuer] Theis, and Hans-Werner [Akademischer Betreuer] Mewes. "Quantification and analysis of single-cell protein dynamics in stem cells using time-lapse microscopy / Michael Schwarzfischer. Gutachter: Fabian J. Theis ; Hans-Werner Mewes. Betreuer: Fabian J. Theis." München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/1060482452/34.

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9

Soon, Chin Fhong. "Development of a novel cell traction force transducer based on cholesteryl ester liquid crystals : characterisation, quantification and evaluation of a cholesteryl ester liquid crystal based single cell force transducer system." Thesis, University of Bradford, 2011. http://hdl.handle.net/10454/5379.

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In biomechano-transducing, cellular generated tension can be measured by soft substrates based on polymers but these techniques are limited either by spatial resolution or ability to detect localised cell traction forces (CTF) due to their non-linear viscous behaviour under shear rates. A newly developed cell traction force transducer system based on cholesteryl ester lyotropic liquid crystals (LCTFT) was developed to sense localised traction forces of human keratinocyte cell lines (HaCaTs), in which the length of the deformation line induced represents the intensity of the CTF exerted. The ph

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10

Meyer, Thomas, Tom Venus, Holger Sieg, et al. "Simultaneous Quantification and Visualization of Titanium Dioxide Nanomaterial Uptake at the Single Cell Level in an In Vitro Model of the Human Small Intestine." Wiley, 2019. https://ul.qucosa.de/id/qucosa%3A70804.

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Useful properties render titanium dioxide nanomaterials (NMs) to be one of the most commonly used NMs worldwide. TiO2 powder is used as food additives (E171), which may contain up to 36% nanoparticles. Consequently, humans could be exposed to comparatively high amounts of NMs that may induce adverse effects of chronic exposure conditions. Visualization and quantification of cellular NM uptake as well as their interactions with biomolecules within cells are key issues regarding risk assessment. Advanced quantitative imaging tools for NM detection within biological environments are therefore req

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11

Squires, James Alexander. "Quantification of post-translationally modified p53 in single cells." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/58866.

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This work outlines efforts towards the development of immunosorbent assays for quantifying post-translationally modified p53, a key tumour suppressor protein, in single cancer cells. These assays utilised the microfluidic antibody capture (MAC) chip to selectively detect post-translationally modified p53 at single molecule sensitivity. Three assays for post-translationally modified p53 were developed; for acetylated-p53, ubiquitinated-p53 and phosphorylated-p53. The assay for acetylated p53, utilising click chemistry, was unsuccessful, as was an approach using antibodies. The assay for ubiquit

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12

Karimiani, Ehsan Ghayoor. "Defining disease risk groups through the quantification of genetic heterogeneity across single leukaemia cells." Thesis, University of Manchester, 2012. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:163858.

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Chronic myeloid leukaemia (CML) is typified by the BCR-ABL fusion gene. Primitive CML cells are less responsive to treatment and have high BCR-ABL mRNA and protein expression. BCR-ABL may also be required for cell adhesion, which may possess increased resistance. Previous studies have analysed bulk cell populations but the significance of BCR-ABL expression heterogeneity at the single cell level is unknown. In this study, the K562 CML cell line was used. Surface-adherent (K562/Adh) and non-adherent (K562/NonAdh) cell populations from standard suspensions were generated through 4 months of pass

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13

"Single Cell Force Spectroscopy for Quantification of Cellular Adhesion on Surfaces." Doctoral diss., 2016. http://hdl.handle.net/2286/R.I.40819.

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abstract: Cell adhesion is an important aspect of many biological processes. The atomic force microscope (AFM) has made it possible to quantify the forces involved in cellular adhesion using a technique called single cell force spectroscopy (SCFS). AFM based SCFS offers versatile control over experimental conditions for probing directly the interaction between specific cell types and specific proteins, surfaces, or other cells. Transmembrane integrins are the primary proteins involved in cellular adhesion to the extra cellular matix (ECM). One of the chief integrins involved in the adhesion of

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14

Tan, Qingyuan. "Development of a Microfluidic Device for Single Cell Specific Membrane Capacitance Quantification." Thesis, 2012. http://hdl.handle.net/1807/33555.

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The specific membrane capacitance (SMC) of biological cell membranes correlates with cells’ electrical activity and morphology, which are physiological markers for cellular phenotype and health. Conventionally, SMC measurements are conducted using electro-rotation and Patch-clamping, which entail long time training and stringent operation skills. Both techniques also suffer from limited throughput and lengthy measurement time. In this study, a microfluidic device, which enables impedance spectroscopy measurements, was developed to quantify the SMC of single biological cells. The device has a t

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15

"Application of single nucleotide polymorphism to quantification of hematopoietic chimerism in children with allogeneic hematopoietic stem cell transplants." 2013. http://library.cuhk.edu.hk/record=b5884358.

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Lau, Wai Hung.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2013.<br>Includes bibliographical references (leaves 141-153).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Abstracts also in Chinese.

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16

"Label Free Methods for the Quantification of Molecular Interaction with Membrane Protein on Cell Surface." Doctoral diss., 2018. http://hdl.handle.net/2286/R.I.51559.

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abstract: Measuring molecular interaction with membrane proteins is critical for understanding cellular functions, validating biomarkers and screening drugs. Despite the importance, developing such a capability has been a difficult challenge, especially for small molecules binding to membrane proteins in their native cellular environment. The current mainstream practice is to isolate membrane proteins from the cell membranes, which is difficult and often lead to the loss of their native structures and functions. In this thesis, novel detection methods for in situ quantification of molecular in

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