Relevant bibliographies by topics / Single-chain Fv

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers
  5. Reports

Academic literature on the topic 'Single-chain Fv'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 January 2023

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Journal articles on the topic "Single-chain Fv"

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Essig, Nina Z., James F. Wood, Andrew J. Howard, Reetta Raag, and Marc Whitlow. "Crystallization of Single-Chain Fv Proteins." Journal of Molecular Biology 234, no. 3 (1993): 897–901. http://dx.doi.org/10.1006/jmbi.1993.1638.

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Huston, J. S., A. J. T. George, F. Jamar, et al. "Perfecting single chain Fv imaging agents." Immunotechnology 2, no. 1 (1996): 67–68. http://dx.doi.org/10.1016/1380-2933(96)80674-9.

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KONG, DENG, XIAOKE WANG, XIAOHONG WANG, et al. "Design, expression and characterization of single chain Fv, Mms13 and the single chain Fv-mms13 fusion protein." Molecular Medicine Reports 12, no. 1 (2012): 1213–18. http://dx.doi.org/10.3892/mmr.2015.3561.

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Moosmann, Anna, Elke Gerlach, Robert Lindner, and Heiner Böttinger. "Purification of a PEGylated single chain Fv." Journal of Chromatography A 1236 (May 2012): 90–96. http://dx.doi.org/10.1016/j.chroma.2012.03.004.

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Chia, Kin Yen, Khuen Yen Ng, Rhun Yian Koh, and Soi Moi Chye. "Single-chain Fv Antibodies for Targeting Neurodegenerative Diseases." CNS & Neurological Disorders - Drug Targets 17, no. 9 (2018): 671–79. http://dx.doi.org/10.2174/1871527317666180315161626.

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Background & Objective: Protein misfolding and aggregation have been considered the common pathological hallmarks for a number of neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD). These abnormal proteins aggregates damage mitochondria and induce oxidative stress, resulting in neuronal cell death. Prolonged neuronal damage activates microglia and astrocytes, development of inflammation reaction and further promotes neurodegeneration. Thus, elimination of abnormal protein aggregates without eliciting any adverse effects ar
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Begent, R. H. J., and K. A. Chester. "Single-chain Fv antibodies for targeting cancer therapy." Biochemical Society Transactions 25, no. 2 (1997): 715–17. http://dx.doi.org/10.1042/bst0250715.

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Griep, Remko A., Charlotte van Twisk, Jan M. van der Wolf, and Arjen Schots. "Fluobodies: green fluorescent single-chain Fv fusion proteins." Journal of Immunological Methods 230, no. 1-2 (1999): 121–30. http://dx.doi.org/10.1016/s0022-1759(99)00131-3.

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Whitlow, Marc, and David Filpula. "Single-chain Fv proteins and their fusion proteins." Methods 2, no. 2 (1991): 97–105. http://dx.doi.org/10.1016/s1046-2023(05)80209-9.

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Wörn, Arne, and Andreas Plückthun. "Stability engineering of antibody single-chain Fv fragments." Journal of Molecular Biology 305, no. 5 (2001): 989–1010. http://dx.doi.org/10.1006/jmbi.2000.4265.

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Han, Seung Hee, and Jin-Kyoo Kim. "The development of anti-DR4 single-chain Fv (ScFv) antibody fused to Escherichia coli alkaline phosphatase." Korean Journal of Microbiology 52, no. 1 (2016): 10–17. http://dx.doi.org/10.7845/kjm.2016.6008.

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Dissertations / Theses on the topic "Single-chain Fv"

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Midelfort, Katarina Senn. "Biophysical characterization of high affinity engineered single chain Fv antibody fragments." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/30051.

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Thesis (Ph. D. in Molecular Systems Toxicology and Pharmacology)--Massachusetts Institute of Technology, Biological Engineering Division, 2004.<br>Vita.<br>Includes bibliographical references.<br>High affinity antibody binding interactions are important for both pharmaceutical and biotechnological uses. However, designing higher affinity interactions has remained difficult. Both high affinity interactions from nature and the results from directed evolution affinity maturation processes may yield clues about the important structural and energetic contributions to attain these tight associations
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Sharma, Vandana. "Generation of single chain Fv protein A fusion molecules for melanoma therapy." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445914/.

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The high incidence rate and absence of a suitable treatment pose a great threat for melanoma patients. Surgery, the main form of treatment for clinically detectable melanoma is unsuitable for micrometastatic disease. Therefore there is a clear need for the development of new adjuvant therapies. We have cloned RAFT3 a single chain Fv specific for melanoma associated chondroitin sulphate proteoglycan (mCSP) fused with 2 artificial S. aureus protein A domains (ZZ). The fusion molecule (R3ZZ) has the potential to redirect both a humoral and a cellular immune response to melanoma. R3ZZ was expresse
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Roberts, Anthony Simon. "The cloning, characterisation and engineering of an IGF-I-BINDING single chain Fv." Thesis, Queensland University of Technology, 2004. https://eprints.qut.edu.au/15914/1/Anthony_Roberts_Thesis.pdf.

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This thesis describes the construction and characterisation of an insulin-like growth factor (IGF-I)-binding single chain Fv (scFv) and the utilisation of this scFv as a model protein for the study of the application of DNA shuffling and ribosome display to antibody engineering. The variable domain genes were isolated from the hybridoma cell line producing the monoclonal antibody and successfully joined by PCR for the construction of the scFv, named anti-GPE. Sequencing of the gene revealed an unusually short heavy chain CDR2 region. The cloned scFv was expressed in E. coli and purified.
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Roberts, Anthony Simon. "The cloning, characterisation and engineering of an IGF-I-BINDING single chain Fv." Queensland University of Technology, 2004. http://eprints.qut.edu.au/15914/.

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This thesis describes the construction and characterisation of an insulin-like growth factor (IGF-I)-binding single chain Fv (scFv) and the utilisation of this scFv as a model protein for the study of the application of DNA shuffling and ribosome display to antibody engineering. The variable domain genes were isolated from the hybridoma cell line producing the monoclonal antibody and successfully joined by PCR for the construction of the scFv, named anti-GPE. Sequencing of the gene revealed an unusually short heavy chain CDR2 region. The cloned scFv was expressed in E. coli and purified. Ex
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Ehlert, Claudia [Verfasser]. "HM1.24 gerichtete bispezifische single-chain-Fv Antikörper zur Therapie des Multiplen Myeloms / Claudia Ehlert." Kiel : Universitätsbibliothek Kiel, 2011. http://d-nb.info/1020165618/34.

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Beavis, Juliet Clare. "The production of single chain antibody Fv fragments by phage display and from hybridoma genes." Thesis, Lancaster University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308983.

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Zhang, Hua. "A human monoclonal anti-melanoma single chain Fv (scFv) antibody derived from tumor-infiltrating B lymphocytes." Diss., The University of Arizona, 1995. http://hdl.handle.net/10150/187293.

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The development of recombinant DNA technology has made it feasible to clone, construct and express fully human immunoglobulin molecules. Here we report a novel methodology to make human antitumor scFv antibodies from tumor-infiltrating B lymphocytes (TIL-B). We isolated and expanded TIL-B from melanomas in the presence of EBV. The transformed B cells secreting tumor-specific antibodies were identified and cloned by limiting dilution. From one B cell clone with specific melanoma reactivity, we captured the immunoglobulin variable region genes, V(H) and V(k), by polymerase chain reaction (peR),
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Le, Calvez Hervé. "Caractérisation par modélisation moléculaire des paratopes de deux single-chain FV anti-cortisol produits chez Escherichia coli." Aix-Marseille 2, 1994. http://www.theses.fr/1994AIX22067.

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Dans le cadre de la biochimie clinique, la specificite des anticorps monoclonaux obtenus par la technique des hybridomes n'est pas suffisamment elevee pour le dosage precis d'une molecule biologique en presence de ses analogues. Afin d'eviter les reactions croisees d'un anticorps monoclonal anti-cortisol, nous devons augmenter sa specificite pour le cortisol en minimisant sa reconnaissance pour ses analogues steroidiens. Notre strategie consiste, dans un premier temps, en l'elaboration d'un vecteur d'expression plasmidique efficace pour produire dans l'espace periplasmique de escherichia coli
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Boleti, Ekaterini. "Characterisation of two anti-tumour single-chain Fv-interleukin-2 fusion proteins and investigation of their immunotherapeutic potential." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397401.

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Lee, Yie Chia. "Structural and interaction studies of an anti-carcinoembryonic antigen single-chain Fv antibody : application to molecular design for cancer targeting." Thesis, University of London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407156.

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Book chapters on the topic "Single-chain Fv"

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Conrad, Udo, Ulrike Fiedler, Olga Artsaenko, and Julian Phillips. "Single-Chain Fv Antibodies Expressed in Plants." In Recombinant Proteins from Plants. Humana Press, 1998. http://dx.doi.org/10.1007/978-1-60327-260-5_9.

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Kontermann, Roland E. "Single-Chain Fv Fragments from Phage Display Libraries." In Vector Targeting for Therapeutic Gene Delivery. John Wiley & Sons, Inc., 2003. http://dx.doi.org/10.1002/0471234303.ch27.

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Biocca, Silvia, Alessio Cardinale, and Antonino Cattaneo. "Expressing Intracellular Single-Chain Fv Fragments in Mammalian Cells." In Antibody Engineering. Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/978-3-662-04605-0_50.

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Guglielmi, Laurence, and Pierre Martineau. "Expression of Single-Chain Fv Fragments in E. coli Cytoplasm." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-302-2_17.

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Filpula, David, Michele Rollence, Nina Essig, James Nagle, Aniruddha Achari, and Timothy Lee. "Engineering of Immunoglobulin Fc and Single-Chain Fv Proteins inEscherichia coli." In ACS Symposium Series. American Chemical Society, 1995. http://dx.doi.org/10.1021/bk-1995-0604.ch006.

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Gahrtz, Manfred, and Udo Conrad. "Immunomodulation of Plant Function by In Vitro Selected Single-Chain Fv Intrabodies." In Recombinant Proteins From Plants. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-407-0_17.

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Poul, Marie Alix, and James D. Marks. "Phage Libraries for Generation of Single Chain Fv Antibodies for Intracellular Immunization." In Intrabodies. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-662-12119-1_2.

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Olafsen, Tove, Vania E. Kenanova, and Anna M. Wu. "Generation of Single-Chain Fv Fragments and Multivalent Derivatives scFv-Fc and scFv-CH3 (Minibodies)." In Antibody Engineering. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-01147-4_6.

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Finlay, William J. J., Laird Bloom, and Orla Cunningham. "Optimized Generation of High-Affinity, High-Specificity Single-Chain Fv Antibodies from Multiantigen Immunized Chickens." In Methods in Molecular Biology. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-913-0_21.

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Lu, Dan, and Zhenping Zhu. "Construction and Production of an IgG-Like Tetravalent Bispecific Antibody, IgG–Single-Chain Fv Fusion." In Methods in Molecular Biology. Humana Press, 2014. http://dx.doi.org/10.1007/978-1-62703-586-6_11.

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Conference papers on the topic "Single-chain Fv"

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Colman, R. W., A. Gewirtz, D. L. Wang, et al. "BIOSYNTHESIS AND EXPRESSION OF FACTOR V IN MAGAKARYOCYTES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642955.

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Coagulation factor V (FV), is a single chain, multifunctional glycoprotein of Mr 350,000 which interacts with a variety of hemostatic proteins such as factor Xa, prothrombin, thrombin and protein C, on the surface of platelets and vascular endothelial cells. FV serves as both a cofactor and substrate in the generation of thrombin and plays a critical regulatory role in both physiologic hemostasis and pathologic thrombosis. The biosynthesis of FV and its subsequent expression are therefore expected to be precisely controlled and may differ in the three sites of synthesis - hepatocytes, endothel
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Reports on the topic "Single-chain Fv"

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Velappan, Nileena. Construction, characterization and crystal structure of a fluorescent single-chain Fv chimera. Office of Scientific and Technical Information (OSTI), 2021. http://dx.doi.org/10.2172/1771063.

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Cheung, Nai-Kong. Single Chain FV Constructs of Anti-Ganglioside GD2 Antibodies for Radioimaging and Radioimmunotherapy. Office of Scientific and Technical Information (OSTI), 2003. http://dx.doi.org/10.2172/900755.

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Cheung, N. K. V., and S. M. Larson. Single chain FV constructs of anti-ganglioside GD2 antibodies for radioimaging and radioimmumotheraphy. Progress report. Office of Scientific and Technical Information (OSTI), 1993. http://dx.doi.org/10.2172/10105853.

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Adams, Gregory P. Rapid Generation and Screening of Novel Bi-Specific Single-Chain FV Molecules Capable of Inhibiting the Growth of Breast Cancer. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada417005.

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