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Dissertations / Theses on the topic 'Single channel recording'

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1

Weatherill, Eve Elizabeth. "Combining single-molecule fluorescence and single-channel recording in droplet interface bilayers." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:99610130-0550-4dd9-b6ee-6ce2297a5bb9.

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Single-channel recordings (SCR) and single-molecule Fluorescence (SMF) are invaluable tools for studying membrane proteins. Combining these two techniques would allow for structural dynamics to be correlated with function at the single-molecule level. However, the different requirements of SCR and SMF measurements present a long-standing challenge. Droplet interface bilayers (DIBs) are a model membrane system in which parallelisation of such measurements is possible using optical single-channel recording to resolve the conductance of multiple proteins simultaneously. In this project, two appro
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2

Spruce, Austen Edwin. "Potassium conductances of skeletal muscle investigated using single channel recording." Thesis, University of Leicester, 1986. http://hdl.handle.net/2381/33614.

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This thesis describes studies of unitary currents flowing through two different potassium (K) channels present in sarcolemmal vesicles of the frog, Rana temporaria. The ATP-regulated K-channel is described first and the results are divided into three parts. Firstly, ATP applied to the cytoplasmic face of a membrane patch closes the channels in a dose-dependent fashion. Different nucleotides and other metabolic substances are used in order to find chemicals which can substitute for ATP or which regulate its effect. Secondly, the permeability properties of the channel are described. Ion flux is
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3

Cao, Tuoxin. "Hydrogen Peroxide and Pharmacological Agent Modulation of TRPV2 Channel Gating." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4848.

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Transient receptor potential vanilloid 2 channel (TRPV2) is a Ca2+-permeable ion channel that is highly expressed in leukocytes but is also present in skeletal and cardiac muscle and endocrine cells. The TRPV2 function is implicated in a number of physiological processes, including bacterial phagocytosis, pro-inflammatory cytokine production, cardiac hypertrophy, and cancer development. TRPV2 knockout mice exhibit a high incidence of perinatal mortality, arguing that the channel plays essential roles in physiology. Despite the importance of TRPV2 for normal homeostasis, the mechanisms that con
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4

Appenrodt, Peter. "Single-channel recordings of potassium channels from guinea-pig inner hair cells." Thesis, University of Sussex, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390054.

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5

Spreadbury, Ian Clive. "Single channel recordings form the BK channels of outer hair cells of the guinea pig cochlea." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322611.

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6

Thei, Federico <1976&gt. "A hybrid technology for parallel recording of single ion channels." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3594/.

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Hybrid technologies, thanks to the convergence of integrated microelectronic devices and new class of microfluidic structures could open new perspectives to the way how nanoscale events are discovered, monitored and controlled. The key point of this thesis is to evaluate the impact of such an approach into applications of ion-channel High Throughput Screening (HTS)platforms. This approach offers promising opportunities for the development of new classes of sensitive, reliable and cheap sensors. There are numerous advantages of embedding microelectronic readout structures strictly coupled to se
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7

Every, Mark Robert. "Separation of musical sources and structure from single-channel polyphonic recordings." Thesis, University of York, 2006. http://etheses.whiterose.ac.uk/9883/.

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8

Jiminez, Gonzalez Aida. "Antenatal foetal monitoring through abdominal phonogram recordings : a single-channel independent component analysis approach." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/190815/.

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9

El, halabi Ramzi. "Blind source separation of single-sensor recordings : Application to ground reaction force signals." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSES031/document.

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Les signaux multicanaux sont des signaux captés à travers plusieurs canaux ou capteurs, portant chacun un mélange de sources, une partie desquelles est connue alors que le reste des sources reste inconnu. Les méthodes à l’aide desquelles l’isolement ou la séparation des sources est accomplie sont connues par les méthodes de séparation de sources en général, et si le degré d’inconnu est large, par la séparation aveugle des sources (SAS). Cependant, la SAS appliquée aux signaux multicanaux est en fait plus facile de point de vue mathématique que l’application de la SAS sur des signaux monocanaux
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10

Kreir, Mohamed [Verfasser]. "Lipid membranes on microstructured glass : Electrophysiological single channels recordings of reconstituted proteins / Mohamed Kreir. Nanion Technologies GmbH." Bremen : IRC-Library, Information Resource Center der Jacobs University Bremen, 2010. http://d-nb.info/1034989294/34.

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11

Thompson, James Russell. "Imaging the assembly of the Staphylococcal pore-forming toxin alpha-Hemolysin." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:e320004a-6118-4dac-af2a-eca6e90be7ac.

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Alpha-hemolysin is a pore-forming toxin secreted by pathogenic Staphylococcus aureus. Its spontaneous oligomerization and assembly into a trans-bilayer beta-barrel pore is a model for the assembly of many other pore-forming toxins. It is studied here in vitro as a means to probe general membrane protein oligomerization and lipid bilayer insertion. This thesis details the results of experiments to develop and implement a novel in vitro lipid bilayer system, Droplet-on-Hydrogel Bilayers (DHBs) for the single-molecule imaging of alpha-hemolysin assembly. Chapter 2 describes the development of DHB
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12

Boileau, Andrew Joseph. "Molecular studies of Paramecium tetraurelia electroporation and single-channel recording /." 1995. http://catalog.hathitrust.org/api/volumes/oclc/32866019.html.

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Thesis (Ph. D.)--University of Wisconsin--Madison, 1995.<br>Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 110-137).
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13

Kaufeld, Theresa. "Lab-on-chip design to characterize pore-spanning lipid bilayers." Doctoral thesis, 2013. http://hdl.handle.net/11858/00-1735-0000-000D-F183-E.

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14

Chih-EnKuo and 郭至恩. "Development of Automatic Sleep Staging Methods for Single-channel Sleep Recordings and Their Related Applications in Sleep Environmental Control." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/98753975825659670538.

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博士<br>國立成功大學<br>資訊工程學系碩博士班<br>101<br>Sleep diseases, such as insomnia and obstructive sleep apnea, seriously affect patients’ quality of life. For diagnosis, polysomnographic (PSG) recordings are most usually taken for sleep stage scoring. However, manual scored by well-trained expert which is a time-consuming and subjective process. Many multi-channel-based automatic sleep staging methods have been developed. These approaches have many drawbacks. For example, the large amount of wires connections for conventional PSG often cause sleep interference and not self-applicable. Sleep EEG signals is
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15

Römer, Winfried [Verfasser]. "Impedance analysis and single ion channel recordings on pore-suspending lipid bilayers based on highly ordered pore arrays / by Winfried Römer." 2006. http://d-nb.info/978213076/34.

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16

Gaßmann, Helmut Albin Oliver. "Integration von Connexonen in Lipidmembranen auf porösen Oberflächen." Doctoral thesis, 2010. http://hdl.handle.net/11858/00-1735-0000-0006-B690-0.

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