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Journal articles on the topic 'Singlet-oxygen therapy'

Author: Grafiati

Published: 3 June 2025

Last updated: 1 August 2025

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1

Cui, Shengdong, Xingran Guo, Sen Wang, et al. "Singlet Oxygen in Photodynamic Therapy." Pharmaceuticals 17, no. 10 (2024): 1274. http://dx.doi.org/10.3390/ph17101274.

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Photodynamic therapy (PDT) is a therapeutic modality that depends on the interaction of light, photosensitizers, and oxygen. The photon absorption and energy transfer process can lead to the Type II photochemical reaction of the photosensitizer and the production of singlet oxygen (1O2), which strongly oxidizes and reacts with biomolecules, ultimately causing oxidative damage to the target cells. Therefore, 1O2 is regarded as the key photocytotoxic species accountable for the initial photodynamic reactions for Type II photosensitizers. This article will provide a comprehensive review of 1O2 pr

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2

Bogdanov, A. A., An A. Bogdanov, V. V. Klimenko, V. S. Burdakov, N. A. Verlov, and V. M. Moiseyenko. "Thermal Effect of IR Radiation at 1273 nm during Direct Photogeneration of Singlet Oxygen for Solid Tumors Therapy." Practical oncology 24, no. 3 (2023): 284–90. http://dx.doi.org/10.31917/2403284.

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Singlet oxygen is an electronically excited state of normal triplet oxygen that has cytotoxic effects. The generation of singlet oxygen as a result of photodynamic therapy is used for the treatment of solid tumors. Methods of singlet oxygen direct photogeneration in tissues using infrared lasers can become an effective alternative to photodynamic therapy. The use of pulsed laser irradiation at 1273 nm with high peak power density is a promising direction. Such modes minimize thermal effects and allow for high peak rates of singlet oxygen generation. In this study, a physical-mathematical model

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3

Fatima, Kaneez, Nusrat Masood, and Suaib Luqman. "Quenching of singlet oxygen by natural and synthetic antioxidants and assessment of electronic UV/Visible absorption spectra for alleviating or enhancing the efficacy of photodynamic therapy." Biomedical Research and Therapy 3, no. 02 (2016): 514–27. http://dx.doi.org/10.15419/bmrat.v3i02.82.

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 Photodynamic therapy (PDT) is one of the methods involved in cancer therapy exploiting singlet oxygen as a weapon to kill cancer cells. Singlet oxygen, a bizarre reactive oxygen species as it is not related to electron transfer to O2 but it is one of the most active intermediate involved in biochemical reactions as it directly reacts with all the major macromolecules like DNA, protein, lipids etc, various photosensitized oxidations and in the photodegradation of dyes and polymers. Recent studies about the usage of antioxidant along with the photo-sensitizer involved in photodynamic ther

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4

Henry, Marc, Miro Radman, Luc Benichou, Khalid O. Alfarouk, and Laurent Schwartz. "Singlet Dioxygen ¹O₂, its Generation, Physico-Chemical Properties and its Possible Hormetic Behavior in Cancer Therapy." Substantia 6, no. 1 (2022): 25–36. http://dx.doi.org/10.36253/substantia-1451.

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Singlet dioxygen 1O2 is one excited state among the three other possible spectroscopic states of molecular oxygen. Here, we first describe the use of published spectroscopic data and thermodynamic modeling based on irreversible entropy production. Such concepts are further applied to the synthesis of singlet dioxygen and its reactions with crucial biological molecules. In a last section, we suggest that singlet dioxygen and ozone may be responsible for the success of radiation therapy, that has been used to treat cancer successfully for over 120 years. Its precise mechanism of action remains c

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5

Zhang, Xian-Fu, and Xiaojie Sun. "Germanium triazatetrabenzcorrole and germanium phthalocyanine: Synthesis, fluorescence and singlet oxygen generation." Journal of Porphyrins and Phthalocyanines 22, no. 09n10 (2018): 847–52. http://dx.doi.org/10.1142/s1088424618500670.

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The synthesis, fluorescence properties and singlet oxygen generation capability of germanium tetrabenzotriazacorrole (LGeTBC), germanium phthalocyanine (Cl[Formula: see text]GePc) and their derivatives are described. Measurements include UV-vis absorption spectra, fluorescence emission spectra, fluorescence quantum yields fluorescence lifetimes, and singlet delta oxygen quantum yields. LGeTBC and its derivatives exhibit quite different spectral and fluorescence properties from their phthalocyanine precursor. Both LGeTBC and Cl[Formula: see text]GePc show high singlet delta oxygen quantum yield

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Liu, Shuai, Yue Hu, Cun Hu, Yan Xiong, and Ming Duan. "Quantum yields of singlet oxygen of tetrakis (4-carboxyphenyl) porphyrin in different solvents." Journal of Porphyrins and Phthalocyanines 23, no. 10 (2019): 1084–91. http://dx.doi.org/10.1142/s1088424619501207.

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The singlet oxygen quantum yields of photosensitizers in different solvents are very important for photodynamic therapy (PDT). Here, we investigated the singlet oxygen quantum yields of tetrakis (4-carboxyphenyl) porphyrin (TCPP) in various solvents by the iodide method. Results indicate that TCPP has different singlet oxygen formation efficiency in different solvents. When compared to TCPP dissolved in water, TCPP showed higher singlet oxygen yields in methanol and ethanol, but lower singlet oxygen yields in DMF under identical conditions. In particular, TCPP rapidly precipitated in acetone a

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Bogdanov, A. A., An A. Bogdanov, V. V. Klimenko, N. A. Verlov, and V. M. Moiseyenko. "Direct photogeneration of singlet oxygen in biological medium for cancer therapy." Practical oncology 24, no. 1 (2023): 39–47. http://dx.doi.org/10.31917/2401039.

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Advances in cancer treatment require continuous improvement and the search for new therapies. Methods for direct photogeneration of singlet oxygen in tissue using IR lasers may be an effective alternative to photodynamic tumor therapy. The physical limitation for the direct photogeneration of singlet oxygen in a biological medium is the low absorption cross section of molecular oxygen. To overcome this limitation, it is necessary to use infrared radiation with a high power density, which in a living system is limited by thermal effects. A promising direction in the development of this approach

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8

Liang, X., T. Busch, and T. C. Zhu. "Singlet oxygen dosimetry modeling for photodynamic therapy." Photodiagnosis and Photodynamic Therapy 8, no. 2 (2011): 142. http://dx.doi.org/10.1016/j.pdpdt.2011.03.063.

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9

Callaghan, Susan, and Mathias O. Senge. "The good, the bad, and the ugly – controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy." Photochemical & Photobiological Sciences 17, no. 11 (2018): 1490–514. http://dx.doi.org/10.1039/c8pp00008e.

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To afford effective photosensitizers and delivery systems for photodynamic therapy their design phase must consider all aspects of singlet oxygen. This perspective highlights that progression of this field is dependent on the control and modulation of its star, singlet oxygen.

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10

Yuan, Youyong, Chong-Jing Zhang, Shidang Xu, and Bin Liu. "A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells." Chemical Science 7, no. 3 (2016): 1862–66. http://dx.doi.org/10.1039/c5sc03583j.

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A probe for the in situ monitoring of singlet oxygen generation during targeted theranostic photodynamic therapy is developed based on a photosensitizer with aggregation-induced emission (AIE) characteristics and conjugated to a fluorogenic rhodol dye via a singlet oxygen cleavable linker.

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11

Przygoda, Maria, Dorota Bartusik-Aebisher, Klaudia Dynarowicz, Grzegorz Cieślar, Aleksandra Kawczyk-Krupka, and David Aebisher. "Cellular Mechanisms of Singlet Oxygen in Photodynamic Therapy." International Journal of Molecular Sciences 24, no. 23 (2023): 16890. http://dx.doi.org/10.3390/ijms242316890.

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In this review, we delve into the realm of photodynamic therapy (PDT), an established method for combating cancer. The foundation of PDT lies in the activation of a photosensitizing agent using specific wavelengths of light, resulting in the generation of reactive oxygen species (ROS), notably singlet oxygen (1O2). We explore PDT’s intricacies, emphasizing its precise targeting of cancer cells while sparing healthy tissue. We examine the pivotal role of singlet oxygen in initiating apoptosis and other cell death pathways, highlighting its potential for minimally invasive cancer treatment. Addi

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12

Peng, Wei, Henriette S. de Bruijn, Timo L. M. ten Hagen, et al. "In-Vivo Optical Monitoring of the Efficacy of Epidermal Growth Factor Receptor Targeted Photodynamic Therapy: The Effect of Fluence Rate." Cancers 12, no. 1 (2020): 190. http://dx.doi.org/10.3390/cancers12010190.

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Targeted photodynamic therapy (PDT) has the potential to improve the therapeutic effect of PDT due to significantly better tumor responses and less normal tissue damage. Here we investigated if the efficacy of epidermal growth factor receptor (EGFR) targeted PDT using cetuximab-IRDye700DX is fluence rate dependent. Cell survival after treatment with different fluence rates was investigated in three cell lines. Singlet oxygen formation was investigated using the singlet oxygen quencher sodium azide and singlet oxygen sensor green (SOSG). The long-term response (to 90 days) of solid OSC-19-luc2-

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13

Bogdanov, A. A., V. V. K. Klimenko, An A. Bogdanov, et al. "Generation of Singlet Oxygen by Laser Infrared Radiation 1273 nm and Evaluation of Cytotoxic Effect on Tumor Cell Lines." Practical oncology 24, no. 3 (2023): 273–83. http://dx.doi.org/10.31917/2403273.

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Increased reactivity makes singlet oxygen a cytotoxic agent. Infrared radiation at 1273 nm allows for direct photogeneration of singlet oxygen without the use of a photosensitizer. In this study, we demonstrated direct photogeneration of singlet oxygen in an aqueous environment using laser radiation at 1273 nm. Using chemical trapping methods, we determined the key parameters of generation, including the generation rate coefficient of singlet oxygen at an irradiance of 1 mW/cm2 and a concentration of dissolved triplet oxygen of 1 μM: ξ=(4.3±0.1) • 10-8 ((s•mW/cm2 )-1). We showed that irradiati

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14

Yang, Weibing, Madelyn Johnson, Baozhu Lu, et al. "Correction of Multispectral Singlet Oxygen Luminescent Dosimetry (MSOLD) for Tissue Optical Properties in Photofrin-Mediated Photodynamic Therapy." Antioxidants 13, no. 12 (2024): 1458. http://dx.doi.org/10.3390/antiox13121458.

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The direct detection of singlet-state oxygen (1O2) constitutes the holy grail dosimetric method for type-II photodynamic therapy (PDT), a goal that can be quantified using multispectral singlet oxygen near-infrared luminescence dosimetry (MSOLD). The optical properties of tissues, specifically their scattering and absorption coefficients, play a crucial role in determining how the treatment and luminescence light are attenuated. Variations in these properties can significantly impact the spatial distribution of the treatment light and hence the generation of singlet oxygen and the detection of

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15

LI, BUHONG, HUIYUN LIN, DEFU CHEN, BRIAN C. WILSON, and YING GU. "SINGLET OXYGEN DETECTION DURING PHOTOSENSITIZATION." Journal of Innovative Optical Health Sciences 06, no. 01 (2013): 1330002. http://dx.doi.org/10.1142/s1793545813300024.

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Singlet oxygen (1O2) is a highly reactive oxygen species involved in numerous chemical and photochemical reactions in different biological systems and in particular, in photodynamic therapy (PDT). However, the quantification of 1O2 generation during in vitro and in vivo photosensitization is still technically challenging. To address this problem, indirect and direct methods for 1O2 detection have been intensively studied. This review presents the available methods currently in use or under development for detecting and quantifying 1O2 generation during photosensitization. The advantages and li

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16

Alcázar, Jackson J. "Thiophene Stability in Photodynamic Therapy: A Mathematical Model Approach." International Journal of Molecular Sciences 25, no. 5 (2024): 2528. http://dx.doi.org/10.3390/ijms25052528.

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Thiophene-containing photosensitizers are gaining recognition for their role in photodynamic therapy (PDT). However, the inherent reactivity of the thiophene moiety toward singlet oxygen threatens the stability and efficiency of these photosensitizers. This study presents a novel mathematical model capable of predicting the reactivity of thiophene toward singlet oxygen in PDT, using Conceptual Density Functional Theory (CDFT) and genetic programming. The research combines advanced computational methods, including various DFT techniques and symbolic regression, and is validated with experimenta

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17

Xu, Xin, Yuecheng Cui, Huixuan Bu, et al. "A photosensitizer loaded hemoglobin–polymer conjugate as a nanocarrier for enhanced photodynamic therapy." Journal of Materials Chemistry B 6, no. 12 (2018): 1825–33. http://dx.doi.org/10.1039/c7tb03109b.

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18

Bamidele, M. Amos-Tautua, P. Songca Sandile, van Vuuren Sandy, and O. Oluwafemi Samuel. "In vitro antibacterial photodynamic action on nosocomial S. aureus using porphyrins as photosensitizers." Chemistry International 9, no. 3 (2023): 104–10. https://doi.org/10.5281/zenodo.8117752.

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The antibacterial photodynamic therapy (aPDT) exerted by porphyrins has been ascribed for the production of singlet oxygen species. This research paper evaluates the singlet oxygen production capacity and photodynamic efficacy of two neutral porphyrins namely,<em> meso</em>-5,10,15,20-tetrakis(4-hydroxylphenyl)porphyrin (m-THPP), <em>meso</em>-5,10,15,20-tetrakis(3-pyridyl)porphyrin (m-T3-PyP) and one cationic <em>meso</em>-5,10,15,20-tetrakis(N-methylpyridinium-3-yl)porphyrin tetra-iodide (m-T-3Py<sup>+</sup>P4I<sup>-</sup>) on nosocomial <em>Staphylococcus aureus</em> (ATCC #25923) strain. A

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19

Dong, Qianya, and Zhenqi Jiang. "Platinum–Iron Nanoparticles for Oxygen-Enhanced Sonodynamic Tumor Cell Suppression." Inorganics 12, no. 12 (2024): 331. https://doi.org/10.3390/inorganics12120331.

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A type of nanoparticle has been developed to simultaneously alleviate tumor hypoxia and enhance the effectiveness of sonodynamic therapy aimed at improving cancer treatment outcomes. Small-sized iron–platinum nanoparticles were prepared using a thermal reduction method, and their particle size and crystal structure were characterized. The ability of these nanoparticles to decompose hydrogen peroxide to produce oxygen and generate singlet oxygen under ultrasound irradiation was further tested. The effect of iron–platinum nanoparticles on inhibition of the proliferation of MCF-7 tumor cells unde

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20

Minaev, Boris. "Photochemistry and Spectroscopy of Singlet Oxygen in Solvents. Recent Advances which Support the Old Theory." Chemistry & Chemical Technology 10, no. 4s (2016): 519–30. http://dx.doi.org/10.23939/chcht10.04si.519.

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Molecular oxygen is a paramagnetic gas with the triplet O2( ) ground state which exhibits just sluggish chemical reactivity in the absence of radical sources. In contrast, the excited metastable singlet oxygen O2( ) is highly reactive; it can oxygenate organic molecules in a wide range of specific reactions which differ from those of the usual triplet oxygen of the air. This makes the singlet oxygen an attractive reagent for new synthesis and even for medical treatments in photodynamic therapy. As an important intermediate O2( ) has attracted great attention of chemists during half-century stu

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Li, Xiaodan, Min Gao, Keting Xin, et al. "Singlet oxygen-responsive micelles for enhanced photodynamic therapy." Journal of Controlled Release 260 (August 2017): 12–21. http://dx.doi.org/10.1016/j.jconrel.2017.05.025.

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22

Maharjan, Prabal Singh, and Hitesh Kumar Bhattarai. "Singlet Oxygen, Photodynamic Therapy, and Mechanisms of Cancer Cell Death." Journal of Oncology 2022 (June 25, 2022): 1–20. http://dx.doi.org/10.1155/2022/7211485.

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Photodynamic therapy (PDT) can be developed into an important arsenal against cancer; it is a minimally invasive therapy, which is used in the treatment or/and palliation of a variety of cancers and benign diseases. The removal of cancerous tissue is achieved with the use of photosensitizer and a light source, which excites the photosensitizer. This excitation causes the photosensitizer to generate singlet oxygen and other reactive oxygen species. PDT has been used in several types of cancers including nonmelanoma skin cancer, bladder cancer, esophageal cancer, head and neck cancer, and non-sm

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23

Pan, Wei, Yegang Ge, Zhengze Yu, et al. "A cancer cell membrane-encapsulated MnO2 nanoreactor for combined photodynamic-starvation therapy." Chemical Communications 55, no. 35 (2019): 5115–18. http://dx.doi.org/10.1039/c9cc01386e.

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24

Kuś, Piotr, Anna Pasewicz-Sokół, Alicja Ratuszna, and Marcin Rojkiewicz. "The synthesis of new potential photosensitizers [1–3]. Part 4. Photophysical properties of some monophenyltripyridyl-porphyrin derivatives." Journal of Porphyrins and Phthalocyanines 19, no. 11 (2015): 1204–11. http://dx.doi.org/10.1142/s1088424615501047.

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Six monophenyltripyridylporphyrin derivatives were synthesized and characterized by spectroscopy in order to demonstrate their potential usefulness as photosensitizers for anticancer therapy purposes. Compounds 1 and 3–5 are amphiphilic, thus they may be suitable for transfer inside cells. Photochemical parameters such as fluorescence yield and singlet oxygen yield were determined. The former parameter does not exceed 10% which makes them unsuitable for photodynamic diagnosis (PDD). However, singlet oxygen yields are high and sufficient for these compounds to be considered as potential photody

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25

Hackbarth, Steffen, Shanghui Gao, Vladimír Šubr, et al. "Singlet Oxygen In Vivo: It Is All about Intensity—Part 2." Journal of Personalized Medicine 13, no. 5 (2023): 781. http://dx.doi.org/10.3390/jpm13050781.

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Recently, we reported induced anoxia as a limiting factor for photodynamic tumor therapy (PDT). This effect occurs in vivo if the amount of generated singlet oxygen that undergoes chemical reactions with cellular components exceeds the local oxygen supply. The amount of generated singlet oxygen depends mainly on photosensitizer (PS) accumulation, efficiency, and illumination intensity. With illumination intensities above a certain threshold, singlet oxygen is limited to the blood vessel and the nearest vicinity; lower intensities allow singlet oxygen generation also in tissue which is a few ce

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Khomutinnikova, L. L., E. P. Bykov, S. A. Plyastsov, et al. "Atmospheric air-phase singlet oxygen generator for practical multifunctional applications." Scientific and Technical Journal of Information Technologies, Mechanics and Optics 25, no. 3 (2025): 406–16. https://doi.org/10.17586/2226-1494-2025-25-3-406-416.

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Singlet oxygen is a metastable reactive oxygen species involved in numerous biochemical reactions and physiological processes. This suggests its potential applicability in addressing practical challenges in medicine and human safety. Due to its oxidative properties, singlet oxygen effectively eliminates pathogenic organisms, including bacteria, fungi, and viruses, and is utilized in photodynamic therapy for the treatment of various diseases, including oncological and dermatological pathologies. Traditionally, photosensitizers are employed for its generation; however, they exhibit significant d

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27

Huang, Ziyuan, Liangfeng Huang, Yanjuan Huang, et al. "Phthalocyanine-based coordination polymer nanoparticles for enhanced photodynamic therapy." Nanoscale 9, no. 41 (2017): 15883–94. http://dx.doi.org/10.1039/c7nr05402e.

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28

Majumdar, Poulomi, Raju Nomula, and Jianzhang Zhao. "Activatable triplet photosensitizers: magic bullets for targeted photodynamic therapy." J. Mater. Chem. C 2, no. 30 (2014): 5982–97. http://dx.doi.org/10.1039/c4tc00659c.

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Nath, Peuli, Sameer Sayel Hamadna, Leshern Karamchand, et al. "Intracellular detection of singlet oxygen using fluorescent nanosensors." Analyst 146, no. 12 (2021): 3933–41. http://dx.doi.org/10.1039/d1an00456e.

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30

Osuchowski, Michał, David Aebisher, Dorota Bartusik-Aebisher, et al. "Photodynamic Therapy-Adjunctive Therapy in the Treatment of Prostate Cancer." Diagnostics 12, no. 5 (2022): 1113. http://dx.doi.org/10.3390/diagnostics12051113.

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The alarming increase in the number of advanced-stage prostate cancer cases with poor prognosis has led to a search for innovative methods of treatment. In response to the need for implementation of new and innovative methods of cancer tissue therapy, we studied photodynamic action in excised prostate tissue in vitro as a model for photodynamic therapy. To ascertain the effects of photodynamic action in prostate tissue, Rose Bengal (0.01 to 0.05 mM) was used as a photosensitizer in the presence of oxygen and light to generate singlet oxygen in tissues in vitro. Five preset concentrations of Ro

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31

Kim, Kyoung-Ran, Duhee Bang, and Dae-Ro Ahn. "Nano-formulation of a photosensitizer using a DNA tetrahedron and its potential for in vivo photodynamic therapy." Biomaterials Science 4, no. 4 (2016): 605–9. http://dx.doi.org/10.1039/c5bm00467e.

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32

Xu, Yao, Xiang Wang, Kang Song, et al. "BSA-encapsulated cyclometalated iridium complexes as nano-photosensitizers for photodynamic therapy of tumor cells." RSC Advances 11, no. 25 (2021): 15323–31. http://dx.doi.org/10.1039/d1ra01740c.

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Bamidele, Martin Amos-Tautua, Fakayode Olayemi, Phinda Songca Sandile, and Oluwatobi Oluwafemi Samuel. "Synthesis, spectroscopic characterization and singlet oxygen generation of 5,10,15,20-tetrakis(3,5-dimethoxyphenyl) porphyrin as a potential photosensitizer for photodynamic therapy." Chemistry International 7, no. 1 (2021): 30–38. https://doi.org/10.5281/zenodo.4018255.

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Singlet oxygen is a valuable reactive oxygen species known for its effective action on the elimination of cancers and age-related eye disease such as macular degeneration. In this study, 5,10,15,20-tetrakis (3,5-dimethoxyphenyl) porphyrin was synthesized and characterized using various spectroscopic methods. The λ<sub>max</sub> for the Soret and Q bands were 417 nm and 514, 547, 589 and 646 (nm) respectively. The estimated singlet oxygen yield (φ<sub>Δ</sub>) for the porphyrin was higher than some literature reports, suggesting a stronger potential of the porphyrin for the pho

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Sakuma, Shiho, Eiko Otake, Kan Torii, et al. "Photodynamic therapy with glycoconjugated chlorin photosensitizer." Journal of Porphyrins and Phthalocyanines 17, no. 05 (2013): 331–42. http://dx.doi.org/10.1142/s1088424613500065.

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Photodynamic therapy (PDT) effectively induces tumor cell apoptosis, but the tumor selectivity and photosensitivity of common photosensitizers, such as aspartyl chlorin (NPe6), are not sufficient. Cancer cells phagocytose glucose 3 to 20 times more efficiently than normal cells; therefore, we examined whether glycoconjugation improves photosensitizer tumor-localizability. HaCaT cells were incubated with H2TFPC (unconjugated chlorin), H2TFPC-SGlc (glycoconjugated chlorin), or NPe6, followed by irradiation with 633 nm LED light (16 J.cm-2). PDT with 1 μM H2TFPC-SGlc for 24 h induced significantl

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Durantini, Andrés M., Lana E. Greene, Richard Lincoln, Sol R. Martínez, and Gonzalo Cosa. "Reactive Oxygen Species Mediated Activation of a Dormant Singlet Oxygen Photosensitizer: From Autocatalytic Singlet Oxygen Amplification to Chemicontrolled Photodynamic Therapy." Journal of the American Chemical Society 138, no. 4 (2016): 1215–25. http://dx.doi.org/10.1021/jacs.5b10288.

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Kue, Chin Siang, Shie Yin Ng, Siew Hui Voon, et al. "Recent strategies to improve boron dipyrromethene (BODIPY) for photodynamic cancer therapy: an updated review." Photochemical & Photobiological Sciences 17, no. 11 (2018): 1691–708. http://dx.doi.org/10.1039/c8pp00113h.

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Do, Thu Thi Anh, Kukuh Wicaksono, Andree Soendoro, Toyoko Imae, María José Garcia-Celma, and Santiago Grijalvo. "Complexation Nanoarchitectonics of Carbon Dots with Doxorubicin toward Photodynamic Anti-Cancer Therapy." Journal of Functional Biomaterials 13, no. 4 (2022): 219. http://dx.doi.org/10.3390/jfb13040219.

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Carbon dots (Cdots) are known as photosensitizers in which the nitrogen doping is able to improve the oxygen-photosensitization performance and singlet-oxygen generation. Herein, the characteristics of nanoconjugates of nitrogen-doped Cdots and doxorubicin were compared with the property of nitrogen-doped Cdots alone. The investigation was performed for the evaluation of pH-dependent zeta potential, quantum yield, photosensitization efficiency and singlet-oxygen generation, besides spectroscopy (UV-visible absorption and fluorescence spectra) and cytotoxicity on cancer model (HeLa cells). Enca

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Lv, Junliang, Xin Zhang, Nana Li, Baoju Wang, and Sailing He. "Absorption-dependent generation of singlet oxygen from gold bipyramids excited under low power density." RSC Advances 5, no. 100 (2015): 81897–904. http://dx.doi.org/10.1039/c5ra15362j.

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Akkalaeva, A. E., A. A. Avanesyan, V. B. Miloserdov, A. A. Bogdanov, and V. M. Moiseyenko. "THE FIRST ExPERIENCE OF USING PULSE-mODE RADIATION DURING UNTRALUmINAL PHOTODYNAmIC THERAPY OF GASTRO-INTESTINAL TRACT AND RESPIRATORY SYSTEm TUmORS." Practical oncology 25, no. 4 (2024): 322–26. https://doi.org/10.31917/2504322.

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40

Myrzakhmetov, Bauyrzhan, Philippe Arnoux, Serge Mordon, Samir Acherar, Irina Tsoy, and Céline Frochot. "Photophysical Properties of Protoporphyrin IX, Pyropheophorbide-a, and Photofrin® in Different Conditions." Pharmaceuticals 14, no. 2 (2021): 138. http://dx.doi.org/10.3390/ph14020138.

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Photodynamic therapy (PDT) is an innovative treatment of malignant or diseased tissues. The effectiveness of PDT depends on light dosimetry, oxygen availability, and properties of the photosensitizer (PS). Depending on the medium, photophysical properties of the PS can change leading to increase or decrease in fluorescence emission and formation of reactive oxygen species (ROS) especially singlet oxygen (1O2). In this study, the influence of solvent polarity, viscosity, concentration, temperature, and pH medium on the photophysical properties of protoporphyrin IX, pyropheophorbide-a, and Photo

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Tavakkoli Yaraki, Mohammad, Yutong Pan, Fang Hu, Yong Yu, Bin Liu, and Yen Nee Tan. "Nanosilver-enhanced AIE photosensitizer for simultaneous bioimaging and photodynamic therapy." Materials Chemistry Frontiers 4, no. 10 (2020): 3074–85. http://dx.doi.org/10.1039/d0qm00469c.

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Yaşa Atmaca, Göknur. "Synthesis of Palladium Phthalocyanine and Investigation of Sono-Photodynamic Therapy Properties." Celal Bayar Üniversitesi Fen Bilimleri Dergisi 16, no. 4 (2020): 367–72. https://doi.org/10.18466/cbayarfbe.754915.

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In this study, it is desired to apply Sono-photodynamic Therapy (SPDT) method to create a more effective therapeutic outcome. For this purpose, a new palladium phthalocyanine (PdPc) (2) was synthesized and characterized by standard spectroscopy methods. Then it's photochemical and photophysical properties were determined in DMSO. Singlet oxygen quantum yield of the complex (2) was calculated by both PDT and SPDT method. The SPDT method (∆ =0.90) was found to be more effective than the PDT method (∆ =0.74), to obtain high singlet oxygen quantum yield. All the results show that, SPDT improves

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Liu, Siyang, Ye Yuan, Yingkun Yang, et al. "Multilayered upconversion nanocomposites with dual photosensitizing functions for enhanced photodynamic therapy." J. Mater. Chem. B 5, no. 41 (2017): 8169–77. http://dx.doi.org/10.1039/c7tb01968h.

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Saravanakumar, Gurusamy, Junseok Lee, Jihoon Kim, and Won Jong Kim. "Visible light-induced singlet oxygen-mediated intracellular disassembly of polymeric micelles co-loaded with a photosensitizer and an anticancer drug for enhanced photodynamic therapy." Chemical Communications 51, no. 49 (2015): 9995–98. http://dx.doi.org/10.1039/c5cc01937k.

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OTSU, Kaoru, Kazuaki SATO, Yoshitaka IKEDA, et al. "An abortive apoptotic pathway induced by singlet oxygen is due to the suppression of caspase activation." Biochemical Journal 389, no. 1 (2005): 197–206. http://dx.doi.org/10.1042/bj20042067.

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Singlet oxygen causes the cytotoxic process of tumour cells in photodynamic therapy. The mechanism by which singlet oxygen damages cells is, however, not fully understood. To address this issue, we synthesized and used two types of endoperoxides, MNPE (1-methylnaphthalene-4-propionate endoperoxide) and NDPE (naphthalene-1,4-dipropionate endoperoxide), that generate defined amounts of singlet oxygen at 37 °C with similar half lives. MNPE, which is more hydrophobic than NDPE, induced the release of cytochrome c from mitochondria into the cytosol and exhibited cytotoxicity, but NDPE did not. RBL

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Soldà, A., A. Cantelli, M. Di Giosia, et al. "C60@lysozyme: a new photosensitizing agent for photodynamic therapy." J. Mater. Chem. B 5, no. 32 (2017): 6608–15. http://dx.doi.org/10.1039/c7tb00800g.

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C<sub>60</sub>@lysozyme showed significant visible light-induced singlet oxygen generation in a physiological environment, indicating the potential of this hybrid as an agent for photodynamic therapy.

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Sachdeva, Akshat. "Photodynamic therapy in dentistry: A literature review." Journal of Dental Panacea 5, no. 1 (2023): 17–20. http://dx.doi.org/10.18231/j.jdp.2023.004.

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Photodynamic therapy is a relatively new non-invasive treatment modality that involves photosensitizers, specific wavelengths of light, and the generation of singlet oxygen and reactive oxygen species. Applications of photodynamic therapy in dentistry are growing rapidly and is slowly reaching all specialties. The present literature review aims to discuss the basic mechanism of photodynamic therapy, its application in various branches of dentistry and its limitations.

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Hwang, Hee Sook, Heejun Shin, Jieun Han, and Kun Na. "Combination of photodynamic therapy (PDT) and anti-tumor immunity in cancer therapy." Journal of Pharmaceutical Investigation 48, no. 2 (2018): 143–51. http://dx.doi.org/10.1007/s40005-017-0377-x.

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Abstract Photodynamic therapy (PDT) is performed using a photosensitizer and light of specific wavelength in the presence of oxygen to generate singlet oxygen and reactive oxygen species(ROS) in the cancer cells. The accumulated photosensitizers in target sites induce ROS generation upon light activation, then the generated cytotoxic reactive oxygen species lead to tumor cell death via apoptosis or necrosis, and damages the target sites which results tumor destruction. As a consequence, the PDT-mediated cell death is associated with anti-tumor immune response. In this paper, the effects of PDT

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HIRANO, Toru. "Measurement of Singlet Oxygen Generated in Photodynamic Therapy (PDT)." Review of Laser Engineering 35, no. 8 (2007): 486–92. http://dx.doi.org/10.2184/lsj.35.486.

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Buhong Li, 李步洪, 林慧韫 Huiyun Lin, 陈德福 Defu Chen, 王敏 Min Wang, and 谢树森 Shusen Xie. "Detection system for singlet oxygen luminescence in photodynamic therapy." Chinese Optics Letters 8, no. 1 (2010): 86–88. http://dx.doi.org/10.3788/col20100801.0086.

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