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Dissertations / Theses on the topic 'Sire genetics'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Zishiri, Oliver Tendayi. "Genetic analyses of South African terminal sire sheep breeds." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/4034.

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Thesis (MScAgric (Animal Sciences))--University of Stellenbosch, 2009.<br>ENGLISH ABSTRACT: Fluctuations and a general decline in the ratio between wool and meat prices resulted in marked changes in the South African sheep industry. Commercial producers now exploit other mechanisms such as terminal crossbreeding of Merino-type with meat type breeds or dual-purpose breeds to attain short-term benefits resulting from price fluctuations between wool and mutton without compromising the wool-producing capacities of ewe flocks. Most components of lamb production have low heritability. However, h

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2

Meinert, Todd Richard. "Factors affecting the accuracy and stability of sire proofs from progeny test herds." Diss., Virginia Tech, 1991. http://hdl.handle.net/10919/39701.

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Change in Modified Contemporary Comparison proofs during first and second crop period was computed from up to eight proofs during both periods for AI and non-AI sampled Holstein bulls with repeatability of last evaluation≥.90. Effect of proof number within testing period on the bull's milk or fat evaluation was estimated with bull absorbed. AI and non-AI sampled bulls' proofs increased from initial first crop proof and then remained fairly constant during the remainder of first crop period. With inclusion of second crop daughters, proofs dropped significantly more for non-AI than AI sampled bu

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3

Marquez, Betz Gabriela Carolina. "Index selection in terminal sire sheep: implications for genetic improvement in a crossbreeding system." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/24774.

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Using terminal sires for crossbreeding is standard practice in the UK sheep industry, where over 70% of market lambs have terminal sire breeding. Thus, selection focusing on terminal sires will translate to changes in the entire industry. Consumers perceive lamb meat as fatty and demand for it has decreased. A lean growth index was developed for terminal sire breeds to increase carcass lean content while keeping fat constant at a constant age end point. The purposes of this study were: to evaluate the effects of index selection of terminal sires on their crossbred offspring up to harvest; to e

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4

Asher, Allison Marie. "CONSERVATION GENETICS OF PADDLEFISH: GENETIC EFFECTIVE POPULATION SIZE AND RANGEWIDE GENETIC STRUCTURE." OpenSIUC, 2019. https://opensiuc.lib.siu.edu/dissertations/1693.

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Paddlefish (Polyodon spathula) is a commercially and recreationally important species, with a native range that extends over 22 US states. This is a large, long-lived, highly mobile riverine species that has been negatively impacted by habitat fragmentation, historic overharvest, and hatchery supplementation. Dams are the primary cause of habitat fragmentation, blocking migration routes, flooding spawning grounds, and isolating populations. A common management action to mitigate the impacts of habitat fragmentation and maintain harvestable populations is hatchery propagation and stocking. Redu

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5

Williamson, Phillip C. "A Novel Mechanism for Site-Directed Mutagenesis of Large Catabolic Plasmids Using Natural Transformation." Thesis, University of North Texas, 2001. https://digital.library.unt.edu/ark:/67531/metadc2828/.

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Natural transformation is the process by which cells take up DNA from the surrounding medium under physiological conditions, altering the genotype in a heritable fashion. This occurs without chemical or physical treatment of the cells. Certain Acinetobacter strains exhibit a strong tendency to incorporate homologous DNA into their chromosomes by natural transformation. Transformation in Acinetobacter exhibits several unique properties that indicate this system's superiority as a model for transformation studies or studies which benefit from the use of transformation as an experimental method

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6

Jonnalagadda, Madhuri. "Site Directed Mutagensis of Bacteriophage HK639 and Identification of Its Integration Site." TopSCHOLAR®, 2008. http://digitalcommons.wku.edu/theses/42.

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Bacteriophages affect bacterial evolution, pathogenesis and global nutrient cycling. They are also the most numerous and diverse group of biological entities on the planet [1, 2, 3, 4, 5, 6]. Members of the Lambda phage family share a similar genetic organization and control early gene expression by suppressing transcription, a process known as antitermination. Transcription antitermination in Lambda is mediated by a phage-encoded protein whereas in lambdoid phage HK022, antitermination is mediated by a phage-encoded RNA molecules. Recent results suggest that another bacteriophage called H

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7

Gattepaille, Lucie. "Population Genetic Methods and Applications to Human Genomes." Doctoral thesis, Uppsala universitet, Evolutionsbiologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-260998.

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Population Genetics has led to countless numbers of fruitful studies of evolution, due to its abilities for prediction and description of the most important evolutionary processes such as mutation, genetic drift and selection. The field is still growing today, with new methods and models being developed to answer questions of evolutionary relevance and to lift the veil on the past of all life forms. In this thesis, I present a modest contribution to the growth of population genetics. I investigate different questions related to the dynamics of populations, with particular focus on studying hum

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8

Eriksson, Jesper. "Structure-Function Studies of Bacteriophage P2 Integrase and Cox protein." Doctoral thesis, Stockholm University, Department of Genetics, Microbiology and Toxicology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-683.

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<p>Probably no group of organisms has been as important as bacteriophages when it comes to the understanding of fundamental biological processes like transcriptional control, DNA replication, site-specific recombination, e.t.c.</p><p>The work presented in this thesis is a contribution towards the complete understanding of these organisms. Two proteins, integrase, and Cox, which are important for the choice of the life mode of bacteriophage P2, are investigated. P2 is a temperate phage, i.e. it can either insert its DNA into the host chromosome (by site-specific recombination) and wait (lysogen

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9

Choo, Yen. "Design of site-specific DNA-binding proteins." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363127.

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10

Sundström, Hannah. "Mutation and Diversity in Avian Sex Chromosomes." Doctoral thesis, Uppsala University, Department of Evolutionary Biology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3732.

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<p>Sex chromosomes are useful for the study of how factors such as mutation, selection, recombination and effective population size affect diversity and divergence.</p><p>A comparison of gametologous introns in seven different bird species revealed a complete lack of diversity on the female-specific W chromosome. In contrast, Z had at least one segregating site in all examined species. This can be explained by the lower mutation rate and lower effective population size of W but also suggests that selection affects diversity levels on the non-recombining W chromosome.</p><p>In a diverse set of

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11

Miranda, Botelho Teixeira Ana Maria. "Structural analysis of the Bilary Glycoprotein (BGP) binding site." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243863.

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12

Grainge, Ian. "Xer site-specific recombination in vitro using Holliday junction substrates." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361923.

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13

Neilson, Liam Michael. "Xer site-specific recombination at dif by Haemophilus influenzae XerC." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299484.

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14

Axelsson, Erik. "Comparative Genomics in Birds." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7432.

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15

Djie, S. N. M. Z. "The role of the reactive site loop in determining serpin specificity." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361551.

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16

Mercian, Amir Feisal. "Role of the arginine repressor, ArgR, in Xer site-specific recombination." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294401.

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17

McLaughlin, Stephen H. M. "The structure and active site chemistry of mammalian protein disulphide isomerase." Thesis, University of Kent, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282427.

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18

Wang, Xing-Guo. "Alteration of substrate specificity in clostridial glutamate dehydrogenase by site-directed mutagenesis." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387762.

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19

Chirakkal, Haridasan. "Enzyme engineering of chloramphenicol acetyltransferase by genetic selection and site-directed mutagenesis." Thesis, University of Sheffield, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267199.

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20

Charlier, Johan. "Monitoring gene level biodiversity - aspects and considerations in the context of conservation." Doctoral thesis, Stockholms universitet, Zoologiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-62796.

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The objectives of this thesis relate to questions needed to be addressed in the context of genetic monitoring for implementing the Convention on Biological Diversity for the gene level. Genetic monitoring is quantifying temporal changes in population genetic metrics. Specific goals of this thesis include i) synthesizing existing information relevant to genetic monitoring of Swedish species, ii) providing a genetic baseline for the Swedish moose, iii) evaluating the relative performance of nuclear versus organelle genetic markers for detecting population divergence, iv) actually monitoring the

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21

Cameron, Neil Donald. "Genetic improvement of lean meat production in terminal sire breeds of sheep." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/12147.

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22

Andronis, Christos. "Site-directed mutagenesis of the D2 protein in the green alga 'Chlamydomonas reihardtii'." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243328.

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23

Plater, Michael L. "Heterologous expression and site-directed mutagenesis of murine aB crystallin chaperone-like protein." Thesis, University of Reading, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360057.

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24

Viney, Ian Stuart. "Genetic analysis of the XerCD site-specific recombinase." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388664.

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25

Parker, Christian N. "Synapsis by resolvase during site-specific recombination." Thesis, University of Bristol, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303752.

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26

Jarjour, Rami A. "Identification of SIX5 binding site, target genes, and functional links with myotonic dystophy (DM1) symptoms." Thesis, University of Glasgow, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274760.

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27

Guo, Yiquan. "Cloning, characterisation and site-selected P-element mutagenesis of genes encoding V-ATPase in Drosophila." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320285.

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28

Howlett, Rory John. "The genetics and evolution of rest-site preference in the lepidoptera." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277869.

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29

Deyle, Anna C. "Population Genetics of Amphiuma means and Siren lacertina in Central Florida." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3071.

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Population structure can be defined as a difference in the frequencies of alleles among populations, and it is often caused by barriers to dispersal. I used mitochondrial DNA sequences to examine the population structure of two large, aquatic salamanders, Amphiuma means (the Two-Toed Amphiuma) and Siren lacertina (the Greater Siren), at two spatial scales in peninsular Florida. Both species appear to have similar life histories, including poor dry land dispersal capabilities, and I hypothesized that they would exhibit significant population structure at both broad and fine scales. Wetland l

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30

Hall, Claire. "Biochemical genetics of glucosinolate side chain modification in Brassica and Arabidopis." Thesis, University of East Anglia, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368170.

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31

Lloyd, John S. "Heterologous expression and site-directed mutagenesis of soluble methane monooxygenase." Thesis, University of Warwick, 1997. http://wrap.warwick.ac.uk/59600/.

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The purpose of this investigation was to study the heterologous expression of soluble methane monooxygenase (sMMO) genes from Methylococcus capsulatus (Bath) and Methylosinus trichosporium OB3b. Using the T7-RNA polymerase expression system, the entire sMMO operon and subclones (constructed using the polymerase chain reaction) were over-expressed in E. coli. Results obtained using the Me. capsulatus (Bath) sMMO operon confirmed previous reports (C. West, G. P. C. Salmond, H. Dalton and 1. C. Murrell (1992). J Gen. Microbial. 138, 1301-1307) that functional expression of protein B and the reduc

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32

Taylor, R. A. V. "Towards the active site of nerve growth factor : studies on nerve growth factor and related neurotrophins." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388545.

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33

Chu, Leslie Elaine. "S phase inheritance of transcriptional silencing: The role of Sir1 and Asf1." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3261228.

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34

Harrison, Sharon Jane. "Targeted transgenesis and the 186 site-specific recombination system /." Title page, summary and contents only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phh322.pdf.

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35

Gossner, Anton Gerhard. "Bio-engineering and genetic manipulation of ovine interleukin-2." Thesis, University of the West of England, Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297877.

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36

Madrzak, Julia. "Site-specific ubiquitination of recombinant proteins via genetic code expansion." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708739.

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37

Taylor, Russell Haywood. "A guanine to adenine mutation -76bp from the transcriptional start site decreases constitutive CYP1A2 expression in a novel mouse strain." Thesis, University of Ottawa (Canada), 2007. http://hdl.handle.net/10393/27924.

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Variations in the expression of drug metabolizing enzymes of the Cytochrome P450 superfamily are a principal cause of atypical reactions to therapeutics. The molecular mechanisms by which the metabolizing enzymes of the drug are regulated, and the effects of genetic variation on this regulation, are not completely understood. Cytochrome P450 1A2 (CYP1A2) is one such enzyme. The APN mouse strain has low expression of the CYP1A2 enzyme, relative to the C3H/HeJ strain. It was hypothesized that this difference in expression of the CYP1A2 was occurring as a result of a single nucleotide polymorphis

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38

Wang, Paul. "Bioinformatic characterisation of the 3' splice site in human genes." Thesis, The University of Sydney, 2006. https://hdl.handle.net/2123/28056.

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Pre—mRNA splicing is an essential part of eukaryotic protein expression. The removal of introns from the pre—mRNA is a complex and highly precise process that requires the embedding of specific signals within the pre—mRNA and accurate detection of these signals by the protein splicing factors. In order to understand the protein—protein and protein—RNA interactions that enable the correct recognition of splice sites and initiation of spliceosome assembly, a two-pronged approach was adopted to investigate splicing from both the protein perspective and the RNA perspective. The former was

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39

Hsieh, Jui-Cheng. "Structure-function analysis of the bacteriophage PRD1 DNA terminal protein: Nucleotide sequence, overexpression, and site-directed mutagenesis of the terminal protein gene." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/184974.

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The nucleotide sequence of the PRD1 terminal protein gene has been determined. The coding region for PRD1 terminal protein is 777 base pairs long and encodes 259 amino acid residues (29,326 daltons). The deduced amino acid sequence of PRD1 terminal protein reveals no overall homology with other known terminal proteins or related proteins. A closer examination revealed a highly conserved amino acid sequence, YSRLRT, exist among all identified DNA terminal proteins including PRD1, PZA, Nf, φ29 and adenovirus. This is the first conserved amino acid sequence that has been found in all identified D

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40

Bolbol, Ahmed A. E. "Genetic analysis of postzygotic hybridisation barriers in Arabidopsis thaliana." Thesis, University of Bath, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537702.

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Most studies of plant hybridisation are concerned with documenting its occurrence in different plant groups. Many flowering plants are polyploids and seeds developed from crosses between individuals of different ploidies usually show abnormal features and often abort. The success or failure of interploidy crosses is very important to understanding the evolution of plants as well as to agriculture, but much remains to be learned about the nature of hybridisation barriers. Several mechanisms have been proposed to explain postzygotic barriers, including negative interactions between diverged sequ

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41

Macfarlane, Hayley Louise. "Engineering site-specific recombinases for use in synthetic biology." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8378/.

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This project examined whether it was possible to create functional hybrid serine integrases – proteins responsible for recombining DNA in a site-specific manner. Creating hybrid recognition sites, specifically engineered to be recognised by the new integrases, was examined concurrently. Ultimately, new serine integrases and recognition sites were created with the intention of increasing the repertoire of serine integrases available for use as independently functioning modules in synthetic biology assemblies. Experiments were carried out primarily on two groups of hybrid integrases – BxbI integ

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42

Brett, Katharina. "Molecular requirements of influenza virus hemagglutinin for site-specific S-acylation and virus replication." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17274.

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Das Hämagglutinin (HA) des Influenzavirus ist post-translational durch S-Acylierung von drei Cysteinen modifiziert. Zwei davon befinden sich in seiner zytoplasmatischen Domäne (CD) und enthalten Palmitat und eines am Cytosol-zugewandten Ende der Transmembranregion (TMR) wird bevorzugt mit Stearat acyliert. Es wird vermutet, dass entweder die Aminosäureumgebung der Acylierungsstelle oder dessen Lage relativ zur Membran bestimmt welcher Fettsäuretyp angeheftet wird. Diese Acylierungstellen sind zudem essentiell für die Virusreplikation. Ob auch andere Aminosäuren der CD essentiell sind, ist nich

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43

Immonen, Elina. "Evolutionary genetics and genomics of the female side of sexual interactions in Drosophila." Thesis, University of St Andrews, 2012. http://hdl.handle.net/10023/3224.

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Sexual interactions play an important role in generating sexual selection and antagonistic co-evolution. These forces can shape differences between the sexes, but also have the potential to generate population divergence and contribute to speciation. The aim in this thesis was to provide new insights into the genes involved in different stages of female sexual interactions, using Drosophila as a model system. In chapter 2 I tested whether a candidate gene (period) that influences species-specific rhythmic characteristics in male courtship song in D. melanogaster also has a pleiotropic effect o

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44

Zhang, Na. "Fine Mapping and Characterization of fw3.2, One of the Major QTL Controlling Fruit Size in Tomato." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1332519563.

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45

Fotinos, Tonya D. "Genetic Structure of the Florida Key Tree Cactus, Pilosocereus robinii, using Restriction Site associated DNA (RAD) markers." FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/914.

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Rare plant conservation efforts must utilize current genetic methods to ensure the evolutionary potential of populations is preserved. One such effort involves the Key Tree Cactus, Pilosocereus robinii, which is an endangered columnar cactus native to the Florida Keys. The populations have precipitously declined over the past decade because of habitat loss and increasing soil salinity from rising sea levels and storm surge. Next-generation DNA sequencing was used to assess the genetic structure of the populations. Twenty individuals representative of both wild and extirpated cacti were chosen

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46

Hutchison, Jordyn M. "SINE Mobilization Analysis to Identify Structural Characteristic That Assists With Cytoplasmic Mobiliziation To the Ribosome." Bowling Green State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu159585433775506.

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47

TEST, A. ROBUSTELLI. "THE ROLE OF ABA IN THE FLORAL TRANSITION: SITE AND MECHANISM OF ACTION." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/525624.

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The reproductive success of plants depends on their developmental plasticity that is the ability to modulate their growth in response to exogenous and endogenous stimuli. Plants efficiently integrate these signals to coordinate their life cycle according to the best conditions to increase their fitness. Light and water availability is a limiting factor for plants sustenance and growth. In Arabidopsis thaliana day length (photoperiod) and water status influence flowering time. In particular, water deficit accelerates flowering thus enabling the drought escape (DE) responses. Interestingly, such

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48

Alotiby, Amna. "Exploring gene editing using site-specific endonucleases as an approach to improve in vitro models of TNF Receptor-Associated Periodic Syndrome (TRAPS)." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/39955/.

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Tumour necrosis factor receptor-associated periodic syndrome is an autoinflammatory disorder caused by mutations in the tumour necrosis factor receptor-type 1 (TNFR1) gene, leading to misfolding of the TNFR1 protein and a resultant chronic inflammatory condition. This study aimed to explore the whether a more physiologically relevant model of TRAPS could be made by gene editing the cell’s endogenous TNFR1 genes. We utilized two site-specific nucleases, TALEN and CRISPR-Cas9 as gene editing tools. These nucleases are able to introduce double-strand DNA breakage at a pre-determined DNA sequence,

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49

Metteauer, Eric Allen. "Response of sire and family group to post-mortem electrical stimulation." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2317.

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50

Waigh, Thomas Andrew. "The structure and side-chain liquid-crystalline polymeric properties of starch." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284951.

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