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Journal articles on the topic 'Sirte'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

Yao, Lijun, and Yinhua Wang. "Bioinformatic Analysis of the Effect of the Sirtuin Family on Differentiated Thyroid Carcinoma." BioMed Research International 2022 (January 30, 2022): 1–15. http://dx.doi.org/10.1155/2022/5794118.

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A growing body of experimental evidence suggests that sirtuins (SIRTs) are associated with tumorigenesis in differentiated thyroid cancer (DTC). Nevertheless, the involvement of SIRTs in the pathogenesis of DTC and their clinical value remain ill-defined and should be thoroughly examined. We explored the transcription of SIRTs and survival data of patients with DTC by the systematic utilization of bioinformatics to analyze data of publicly accessible databases including Oncomine, cBioPortal, Kaplan-Meier Plotter, Gene Expression Profiling Interactive Analysis (GEPIA), Protein Atlas, LinkedOmic

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Słuczanowska-Głabowska, Sylwia, Maria Salmanowicz, Marzena Staniszewska, and Andrzej Pawlik. "The Role of Sirtuins in the Pathogenesis of Psoriasis." International Journal of Molecular Sciences 24, no. 13 (2023): 10782. http://dx.doi.org/10.3390/ijms241310782.

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Psoriasis is the most common chronic inflammatory skin disease with a genetic basis. It is characterised by keratinocyte hyperproliferation, parakeratosis and inflammatory cell infiltration. Psoriasis negatively affects a patient’s physical and emotional quality of life. Sirtuins (SIRTs; silent information regulators) are an evolutionarily conserved group of enzymes involved in the post-translational modification of proteins, including deacetylation, polyADP-ribosylation, demalonylation and lipoamidation. SIRTs are involved in a number of cellular pathways related to ageing, inflammation, oxid

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Zhang, Xiaomin, Fathima Ameer, Jasmine Crane, Gohar Azhar, and Jeanne Wei. "Effect of Nutritional Stress on the Expression of Sirtuin Gene Family." Innovation in Aging 4, Supplement_1 (2020): 124. http://dx.doi.org/10.1093/geroni/igaa057.407.

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Abstract The sirtuin (SIRT) proteins are a highly conserved family of NAD+-dependent deacetylases that regulate histones as well as non-histone proteins. Seven sirtuin genes have been identified (SIRT1 to SIRT7) in mammals. SIRT1, SIRT6, and SIRT7 are primarily localized in the nucleus. SIRT2 is localized mainly in the cytoplasm. SIRT3, SIRT4, and SIRT5 are often located in the mitochondria. Therefore, the sirtuin family proteins exert their diverse functions at various cellular locations and regulate metabolism, stress responses, growth and aging processes. The sirtuin proteins are often cons

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Nowacka, Agnieszka, Martyna Śniegocka, Maciej Śniegocki, and Ewa Aleksandra Ziółkowska. "Sirtuins in Central Nervous System Tumors—Molecular Mechanisms and Therapeutic Targeting." Cells 14, no. 14 (2025): 1113. https://doi.org/10.3390/cells14141113.

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Sirtuins (SIRTs), a family of NAD+-dependent enzymes, play crucial roles in epigenetic regulation, metabolism, DNA repair, and stress response, making them relevant to glioma biology. This review systematically summarizes the molecular mechanisms and context-specific functions of SIRT1–SIRT7 in central nervous system tumors, with particular focus on gliomas. SIRT1, SIRT3, SIRT5, and SIRT7 are often overexpressed and promote glioma cell proliferation, stemness, therapy resistance, and metabolic adaptation. Conversely, SIRT2, SIRT4, and SIRT6 generally exhibit tumor-suppressive functions by indu

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González-Fernández, Rebeca, Rita Martín-Ramírez, Deborah Rotoli, et al. "Granulosa-Lutein Cell Sirtuin Gene Expression Profiles Differ between Normal Donors and Infertile Women." International Journal of Molecular Sciences 21, no. 1 (2019): 295. http://dx.doi.org/10.3390/ijms21010295.

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Sirtuins are a family of deacetylases that modify structural proteins, metabolic enzymes, and histones to change cellular protein localization and function. In mammals, there are seven sirtuins involved in processes like oxidative stress or metabolic homeostasis associated with aging, degeneration or cancer. We studied gene expression of sirtuins by qRT-PCR in human mural granulosa-lutein cells (hGL) from IVF patients in different infertility diagnostic groups and in oocyte donors (OD; control group). Study 1: sirtuins genes’ expression levels and correlations with age and IVF parameters in wo

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Huarachi Olivera, Ronald Eleazar, and Antonio Lazarte Rivera. "Enfermedad del coronavirus (covid-19) y las sirtuinas." Revista de la Facultad de Ciencias Médicas de Córdoba 77, no. 2 (2020): 117–25. http://dx.doi.org/10.31053/1853.0605.v77.n2.28196.

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Las proteínas desacetilasas dependientes del NAD+, se denominan Sirtuinas (SIRT). Objetivos: estudiar las sirtuinas involucradas en el cáncer, así como los estudios de inhibición de SIRT1 en pacientes con la enfermedad del coronavirus COVID-19. Fuente y selección de datos: Para ello se realizó una búsqueda en Medline, Scopus y WOS, donde se incluyeron estudios descriptivos de cada una de las funciones de las sirtuinas ajustado a las recientes investigaciones científicas. La inhibición de SIRT1 disminuye la citotoxicidad de las células T CD8 en pacientes con lupus eritematoso sistémico, s

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Hsu, Yi-Chao, Yu-Ting Wu, Chia-Ling Tsai, and Yau-Huei Wei. "Current understanding and future perspectives of the roles of sirtuins in the reprogramming and differentiation of pluripotent stem cells." Experimental Biology and Medicine 243, no. 6 (2018): 563–75. http://dx.doi.org/10.1177/1535370218759636.

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In mammalian cells, there are seven members of the sirtuin protein family (SIRT1–7). SIRT1, SIRT6, and SIRT7 catalyze posttranslational modification of proteins in the nucleus, SIRT3, SIRT4, and SIRT5 are in the mitochondria and SIRT2 is in the cytosol. SIRT1 can deacetylate the transcription factor SOX2 and regulate induced pluripotent stem cells (iPSCs) reprogramming through the miR-34a–SIRT1–p53 axis. SIRT2 can regulate the function of pluripotent stem cells through GSK3β. SIRT3 can positively regulate PPAR gamma coactivator 1-alpha (PGC-1α) expression during the differentiation of stem cel

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Nowicki, Mateusz, Agnieszka Wierzbowska, Emilia Stec-Martyna, Dominika Kulczycka-Wojdala, Grzegorz Nowicki, and Anna Szmigielska-Kapłon. "SIRT1-SIRT7 Expression in Patients with Lymphoproliferative Disorders Undergoing Hematopoietic Stem Cell Mobilization." Cancers 14, no. 5 (2022): 1213. http://dx.doi.org/10.3390/cancers14051213.

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Sirtuins are involved in the fate of hematopoietic stem cells (HSCs), including their metabolism, stress response, differentiation, migration, and apoptosis. The aim of this study was to explore SIRT1-7 expression during HSC mobilization. The study included 50 patients with lymphoproliferative disorders (39 multiple myeloma, 11 lymphoma). Samples were taken before mobilization (day 0) and on the day of first apheresis (day A). The sirtuin expression was evaluated by the Droplet Digital PCR (ddPCR) method. A significant increase of the SIRT1, SIRT2, SIRT3, SIRT5, SIRT6, and SIRT7 levels measure

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Goes, João Vitor Caetano, Luiz Gustavo Carvalho, Roberta Taiane Germano De Oliveira, et al. "Perfil de expressão gênica da via de deacetilação de histonas mediada por Sirtuinas na estratificação prognóstica da Síndrome Mielodisplásica." Brazilian Journal of Case Reports 2, Suppl.1 (2022): 20. http://dx.doi.org/10.52600/2763-583x.bjcr.2022.2.suppl.1.20.

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Introdução: A relação entre a senescência e o câncer é alvo de estudos, tanto em contexto carcinogênico quanto na supressão tumoral. Considerados importantes marcadores de envelhecimento, as sirtuinas podem auxiliar na medicina preventiva do câncer. Entretanto, estudos com esses marcadores em Síndrome Mielodisplásica ainda são escassos. Objetivo: Investigar o papel das sirtuinas (SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6 e SIRT7) na patogênese e na evolução prognóstica da Síndrome Mielodisplásica em um estudo do tipo caso-controle retro-prospectivo. Metodologia: Foram selecionados 106 pacientes

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Peng, Lu-Shan, Sai-Li Duan, Run-Qi Li, Zi-Yuan Bai, Chun-Lin Ou, and Jun-Pu Wang. "Prognostic value of sirtuin family members and experimental verification identify SIRT5 as diagnostic biomarkers in clear cell renal cell carcinoma." PeerJ 11 (April 19, 2023): e15154. http://dx.doi.org/10.7717/peerj.15154.

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Background The sirtuins (SIRTs) family is a nicotinamide adenine dinucleotide (NAD+) family of dependent deacetylases, which includes SIRT1-7. This family is related to the development and progression of various tumors. However, a comprehensive analysis of the role of SIRTs in clear cell renal cell carcinoma (ccRCC) is still lacking, and there are few reports on the inhibitory role of SIRT5 in ccRCC. Methods We used immunohistochemical analysis, and several bioinformatic databases to perform an integrated analysis of the expression and prognostic value of SIRT5 and other SIRT family members in

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Ungurianu, Anca, Anca Zanfirescu, and Denisa Margină. "Regulation of Gene Expression through Food—Curcumin as a Sirtuin Activity Modulator." Plants 11, no. 13 (2022): 1741. http://dx.doi.org/10.3390/plants11131741.

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The sirtuin family comprises NAD+-dependent protein lysine deacylases, mammalian sirtuins being either nuclear (SIRT1, SIRT2, SIRT6, and SIRT7), mitochondrial (SIRT3, SIRT4, and SIRT5) or cytosolic enzymes (SIRT2 and SIRT5). They are able to catalyze direct metabolic reactions, thus regulating several physiological functions, such as energy metabolism, stress response, inflammation, cell survival, DNA repair, tissue regeneration, neuronal signaling, and even circadian rhythms. Based on these data, recent research was focused on finding molecules that could regulate sirtuins’ expression and/or

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Yu, Nian-Da, Bing Wang, Xin-Zhu Li, Hao-Zhen Han, and Dongxiang Liu. "A Novel Mechanism for SIRT1 Activators That Does Not Rely on the Chemical Moiety Immediately C-Terminal to the Acetyl-Lysine of the Substrate." Molecules 27, no. 9 (2022): 2714. http://dx.doi.org/10.3390/molecules27092714.

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SIRT1, an NAD+-dependent deacetylase, catalyzes the deacetylation of proteins coupled with the breakdown of NAD+ into nicotinamide and 2′-O-acetyl-ADP-ribose (OAADPr). Selective SIRT1 activators have potential clinical applications in atherosclerosis, acute renal injury, and Alzheimer’s disease. Here, we found that the activity of the potent SIRT1 activator CWR is independent of the acetylated substrate. It adopts a novel mechanism to promote SIRT1 activity by covalently bonding to the anomeric C1′ carbon of the ribose ring in OAADPr. In addition, CWR is highly selective for SIRT1, with no eff

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Michishita, Eriko, Jean Y. Park, Jenna M. Burneskis, J. Carl Barrett, and Izumi Horikawa. "Evolutionarily Conserved and Nonconserved Cellular Localizations and Functions of Human SIRT Proteins." Molecular Biology of the Cell 16, no. 10 (2005): 4623–35. http://dx.doi.org/10.1091/mbc.e05-01-0033.

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Sir2 is a NAD+-dependent protein deacetylase that extends lifespan in yeast and worms. This study examines seven human proteins homologous to Sir2 (SIRT1 through SIRT7) for cellular localization, expression profiles, protein deacetylation activity, and effects on human cell lifespan. We found that: 1) three nuclear SIRT proteins (SIRT1, SIRT6, and SIRT7) show different subnuclear localizations: SIRT6 and SIRT7 are associated with heterochromatic regions and nucleoli, respectively, where yeast Sir2 functions; 2) SIRT3, SIRT4, and SIRT5 are localized in mitochondria, an organelle that links agin

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Matsushima, Shouji, and Junichi Sadoshima. "The role of sirtuins in cardiac disease." American Journal of Physiology-Heart and Circulatory Physiology 309, no. 9 (2015): H1375—H1389. http://dx.doi.org/10.1152/ajpheart.00053.2015.

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Modification of histones is one of the important mechanisms of epigenetics, in which genetic control is determined by factors other than an individual's DNA sequence. Sirtuin family proteins, which are class III histone deacetylases, were originally identified as gene silencers that affect the mating type of yeast, leading to the name “silent mating-type information regulation 2” (SIR2). They are characterized by their requirement of nicotinamide adenine dinucleotide for their enzyme activity, unlike other classes of histone deacetylases. Sirtuins have been traditionally linked to longevity an

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Kalous, Kelsey S., Sarah L. Wynia-Smith, Steven B. Summers, and Brian C. Smith. "Human sirtuins are differentially sensitive to inhibition by nitrosating agents and other cysteine oxidants." Journal of Biological Chemistry 295, no. 25 (2020): 8524–36. http://dx.doi.org/10.1074/jbc.ra119.011988.

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Sirtuins (e.g. human Sirt1–7) catalyze the removal of acyl groups from lysine residues in proteins in an NAD+-dependent manner, and loss of sirtuin deacylase activity correlates with the development of aging-related diseases. Although multiple reports suggest that sirtuin activity is regulated by oxidative post-translational modifications of cysteines during inflammation and aging, no systematic comparative study of potential direct sirtuin cysteine oxidative modifications has been performed. Here, using IC50 and kinact/KI analyses, we quantified the ability of nitrosothiols (S-nitrosoglutathi

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Schmid, Nina, Kim-Gwendolyn Dietrich, Ignasi Forne, et al. "Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors." International Journal of Molecular Sciences 22, no. 4 (2021): 2047. http://dx.doi.org/10.3390/ijms22042047.

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Sirtuins (SIRTs) are NAD+-dependent deacetylases that regulate proliferation and cell death. In the human ovary, granulosa cells express sirtuin 1 (SIRT1), which has also been detected in human tumors derived from granulosa cells, i.e., granulosa cell tumors (GCTs), and in KGN cells. KGN cells are an established cellular model for the majority of GCTs and were used to explore the role of SIRT1. The SIRT1 activator SRT2104 increased cell proliferation. By contrast, the inhibitor EX527 reduced cell numbers, without inducing apoptosis. These results were supported by the outcome of siRNA-mediated

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Das, Undurti N. "“Cell Membrane Theory of Senescence” and the Role of Bioactive Lipids in Aging, and Aging Associated Diseases and Their Therapeutic Implications." Biomolecules 11, no. 2 (2021): 241. http://dx.doi.org/10.3390/biom11020241.

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Lipids are an essential constituent of the cell membrane of which polyunsaturated fatty acids (PUFAs) are the most important component. Activation of phospholipase A2 (PLA2) induces the release of PUFAs from the cell membrane that form precursors to both pro- and ant-inflammatory bioactive lipids that participate in several cellular processes. PUFAs GLA (gamma-linolenic acid), DGLA (dihomo-GLA), AA (arachidonic acid), EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are derived from dietary linoleic acid (LA) and alpha-linolenic acid (ALA) by the action of desaturases whose activity

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Chouhan, Surbhi, Naoshad Muhammad, Darksha Usmani, Tabish H. Khan, and Anil Kumar. "Molecular Sentinels: Unveiling the Role of Sirtuins in Prostate Cancer Progression." International Journal of Molecular Sciences 26, no. 1 (2024): 183. https://doi.org/10.3390/ijms26010183.

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Prostate cancer (PCa) remains a critical global health challenge, with high mortality rates and significant heterogeneity, particularly in advanced stages. While early-stage PCa is often manageable with conventional treatments, metastatic PCa is notoriously resistant, highlighting an urgent need for precise biomarkers and innovative therapeutic strategies. This review focuses on the dualistic roles of sirtuins, a family of NAD+-dependent histone deacetylases, dissecting their unique contributions to tumor suppression or progression in PCa depending on the cellular context. It reveals their mul

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Chouhan, Surbhi, Anil Kumar, Naoshad Muhammad, Darksha Usmani, and Tabish H. Khan. "Sirtuins as Key Regulators in Pancreatic Cancer: Insights into Signaling Mechanisms and Therapeutic Implications." Cancers 16, no. 23 (2024): 4095. https://doi.org/10.3390/cancers16234095.

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Pancreatic ductal adenocarcinoma (PDAC) stands as one of the most lethal cancers, marked by rapid progression, pronounced chemoresistance, and a complex network of genetic and epigenetic dysregulation. Within this challenging context, sirtuins, NAD+-dependent deacetylases, have emerged as pivotal modulators of key cellular processes that drive pancreatic cancer progression. Each sirtuin contributes uniquely to PDAC pathogenesis. SIRT1 influences apoptosis and chemoresistance through hypoxia, enhancing glycolytic metabolism and HIF-1α signaling, which sustain tumor survival against drugs like g

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Sengupta, Surojeet, Karla de Oliveira, Lu Jin, and Robert Clarke. "RF05 | PSUN341 Role of sirtuins in breast cancer cells response to Fulvestrant." Journal of the Endocrine Society 6, Supplement_1 (2022): A891. http://dx.doi.org/10.1210/jendso/bvac150.1845.

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Abstract Endocrine therapies reduce glucose and glutamine uptake and total cellular ATP production in breast cancer (BC) cells, resulting in changes in cellular nutrient balance that could lead to cell cycle arrest and to cell death. Understanding the ability of cells to bypass these metabolic effects is fundamental to understand acquisition of endocrine resistance and cross-resistance to other drugs by BC cells. Sirtuins (SIRTs) are NAD+-dependent deacylases involved in a variety of cellular processes, including metabolism and stress responses. SIRT1 deacetylates histones and transcription fa

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Teena, Rajan, Umapathy Dhamodharan, Daoud Ali, Kesavan Rajesh, and Kunka Mohanram Ramkumar. "Gene Expression Profiling of Multiple Histone Deacetylases (HDAC) and Its Correlation with NRF2-Mediated Redox Regulation in the Pathogenesis of Diabetic Foot Ulcers." Biomolecules 10, no. 10 (2020): 1466. http://dx.doi.org/10.3390/biom10101466.

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Nuclear factor erythroid-2-related factor 2 (Nrf2) is a protein of the leucine zipper family, which mitigates inflammation and employs cytoprotective effects. Attempting to unravel the epigenetic regulation of type 2 diabetes mellitus (T2DM) and diabetic foot ulcer (DFU), we profiled the expression of eleven isoform-specific histone deacetylases (HDACs) and correlated them with NRF2 and cytokines. This study recruited a total of 60 subjects and categorized into DFU patients (n = 20), T2DM patients (n = 20), and healthy controls (n = 20). The DFU patients were subcategorized into uninfected and

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Colloca, Antonino, Anna Balestrieri, Camilla Anastasio, Maria Luisa Balestrieri, and Nunzia D’Onofrio. "Mitochondrial Sirtuins in Chronic Degenerative Diseases: New Metabolic Targets in Colorectal Cancer." International Journal of Molecular Sciences 23, no. 6 (2022): 3212. http://dx.doi.org/10.3390/ijms23063212.

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Sirtuins (SIRTs) are a family of class III histone deacetylases (HDACs) consisting of seven members, widely expressed in mammals. SIRTs mainly participate in metabolic homeostasis, DNA damage repair, cell survival, and differentiation, as well as other cancer-related biological processes. Growing evidence shows that SIRTs have pivotal roles in chronic degenerative diseases, including colorectal cancer (CRC), the third most frequent malignant disease worldwide. Metabolic alterations are gaining attention in the context of CRC development and progression, with mitochondrion representing a crucia

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Bruzzone, Santina, Marco Daniele Parenti, Alessia Grozio, et al. "Rejuvenating Sirtuins: The Rise of a New Family of Cancer Drug Targets." Current Pharmaceutical Design 19, no. 4 (2013): 614–23. http://dx.doi.org/10.2174/138161213804581954.

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Sirtuins are a family of NAD+-dependent enzymes that was proposed to control organismal life span about a decade ago. While such role of sirtuins is now debated, mounting evidence involves these enzymes in numerous physiological processes and disease conditions, including metabolism, nutritional behavior, circadian rhythm, but also inflammation and cancer. SIRT1, SIRT2, SIRT3, SIRT6, and SIRT7 have all been linked to carcinogenesis either as tumor suppressor or as cancer promoting proteins. Here, we review the biological rationale for the search of sirtuin inhibitors and activators for treatin

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De Oliveira, Karla A., Surojeet Sengupta, Lu Jin, and Robert Clarke. "Abstract 2339: Fulvestrant regulation of SIRT1 and SIRT3 expression in breast cancer cells." Cancer Research 82, no. 12_Supplement (2022): 2339. http://dx.doi.org/10.1158/1538-7445.am2022-2339.

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Abstract Estrogen receptor positive (ER+) breast cancers (BC) that do not respond to endocrine therapies exhibit lower response rates to chemotherapy than other subtypes, implying that endocrine resistance may confer cross-resistance to cytotoxic drugs and contribute to the poor responses to chemotherapy in recurrent ER+ disease. Endocrine therapies can reduce glucose (GLC) and glutamine uptake and total cellular ATP production in BC cells, and the ability of cells to bypass this metabolic stress is fundamental to how endocrine therapies regulate BC growth in a way that leads to acquired endoc

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Korytina, G. F., V. A. Markelov, L. Z. Akhmadishina, et al. "Nad-dependent deacetylase genes of sirtuin family and risk of developing various phenotypes of chronic obstructive pulmonary disease." YAKUT MEDICAL JOURNAL 83, no. 3 (2023): 14–17. https://doi.org/10.25789/ymj.2023.83.03.

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Chronic obstructive pulmonary disease (COPD) is one of the most common chronic respiratory diseases with high morbidity and mortality. The pathogenesis of COPD is closely related to oxidative stress, that is the main mechanism causes accelerated cell senescence. Published data suggest that the COPD pathogenesis may involve stress responses dysregulation that inhibit cellular senescence. We aimed to assess the contribution of sirtuin genes (SIRT2, SIRT1, SIRT3, SIRT6) to the various COPD phenotypes risk. SNPs of SIRT2 (rs10410544), SIRT1 (rs3758391, rs3818292), SIRT3 (rs3782116, rs536715), SIRT

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Lombard, David. "Novel Roles for the Sirtuin Deacylase SIRT5 in Normal Physiology and in Cancer." Innovation in Aging 4, Supplement_1 (2020): 741. http://dx.doi.org/10.1093/geroni/igaa057.2652.

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Abstract Sirtuins are NAD+-dependent deacylases that regulate diverse cellular processes such as metabolic homeostasis and genomic integrity. Mammals possess seven sirtuin family members, SIRT1-SIRT7, that display diverse subcellular localization patterns, catalytic activities, protein targets, and biological functions. Three sirtuins, SIRT3, SIRT4, and SIRT5, are primarily located in the mitochondrial matrix. SIRT5 is a very inefficient deacetylase, instead removing negatively charged post-translational modifications (succinyl, glutaryl, and malonyl groups) from lysines of its target proteins

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Song, Xingfa, Haidong Wang, Chao Wang, et al. "Association of Sirtuin Gene Polymorphisms with Susceptibility to Coronary Artery Disease in a North Chinese Population." BioMed Research International 2022 (February 18, 2022): 1–8. http://dx.doi.org/10.1155/2022/4294008.

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Aims. Coronary artery disease (CAD) represents the leading cause of death worldwide. Accumulating evidence also suggests that sirtuins (SIRTS) have been associated with CAD. The present study was aimed at investigating the association between 12 gene polymorphisms for SIRTs and the development of CAD in a Chinese population. Materials and Methods. 12 SNPs (rs12778366 ( T > C ), rs3758391 ( T > C ), rs3740051 ( A > G ), rs4746720 ( C > T ), rs7895833 ( G > A ), rs932658 ( A > C ) for SIRT1, rs2015 ( G > T ) for SIRT2, rs28365927 ( G > A ), rs11246020 ( C > T ) for SIR

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Jaszcza, Klaudia, Mirosław Kucharski, and Agnieszka K. Grzegorzewska. "Immunolocalisation and mRNA expression of selected sirtuins in the avian liver." Folia Biologica 72, no. 3 (2024): 97–108. http://dx.doi.org/10.3409/fb_72-3.10.

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J aszcza K., K ucharski M., G rzegorzewska A. K. 2024. Immunolocalisation and mRNA expression of selected sirtuins in the avian liver. Folia Biologica (Kraków) 72: 97-108. Sirtuins are evolutionary conserved enzymes that function as NAD+ -dependent deacetylases and ribosyl-transferases. Seven sirtuins (SIRT1-7) with specific distributions and functions in the cell have been detected in mammals. They have also been detected in birds. Sirtuins regulate the DNA repair function, the cell cycle and metabolism. Many studies concerning anti-aging factors are currently focused on the potential of sirt

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Strzalka, Piotr, Kinga Krawiec, Dariusz Jarych, et al. "Assessment of SIRT1-SIRT7 and TP53 Genes Expression in Patients with Acute Myeloid Leukemia." Blood 142, Supplement 1 (2023): 6048. http://dx.doi.org/10.1182/blood-2023-187756.

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BACKGROUND Sirtuins ( SIRTs) are a family of histone deacetylases with 7 representatives ( SIRT1-7), which affect cell survival and metabolism. They influence gene expression by interacting with histones and transcription factors, or directly modulate pathways associated with cell survival, for instance by downregulating p53, thus potentially contributing to cancerogenesis. On the other hand, SIRTs may function as tumor suppressors depending on cellular context. While the role of SIRTs expression is widely discussed in solid neoplasms, they have not been comprehensively evaluated in acute myel

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Korytina, G. F., L. Z. Akhmadishina, V. A. Markelov, et al. "Role of PI3K/AKT/mTOR signaling pathway and sirtuin genes in chronic obstructive pulmonary disease development." Vavilov Journal of Genetics and Breeding 27, no. 5 (2023): 512–21. http://dx.doi.org/10.18699/vjgb-23-62.

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Chronic obstructive pulmonary disease (COPD) is a multifactorial disease of the respiratory system which develops as a result of a complex interaction of genetic and environmental factors closely related to lifestyle. We aimed to assess the combined effect of the PI3K/AKT/mTOR signaling pathway (PIK3R1, AKT1, MTOR, PTEN) and sirtuin (SIRT1, SIRT3, SIRT6) genes to COPD risk. SNPs of SIRT1 (rs3758391, rs3818292), SIRT3 (rs3782116, rs536715), SIRT6 (rs107251), AKT1 (rs2494732), PIK3R1 (rs10515070, rs831125, rs3730089), MTOR (rs2295080, rs2536), PTEN (rs701848, rs2735343) genes were genotyped by r

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Czerewaty, Michał, Łukasz Ustianowski, Kajetan Kiełbowski, et al. "Placental Expression of Sirtuins in Women with Gestational Diabetes." Genes 16, no. 7 (2025): 844. https://doi.org/10.3390/genes16070844.

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Background/Objectives: Gestational diabetes mellitus (GDM) is a common metabolic disorder in pregnant women. It can lead to several complications, such as preterm delivery, macrosomia, or metabolic disorders in newborns. Studies have revealed morphological and transcriptional differences between the placentas of patients with GDM and women with normal glucose tolerance. Sirtuins (SIRTs) are nicotinamide adenine dinucleotide-dependent deacetylases that interact with and regulate the activity of numerous proteins. However, little is known about their role in the pathogenesis of GDM. This study w

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Potthast, Arne Björn, Josefine Nebl, Paulina Wasserfurth, et al. "Impact of Nutrition on Short-Term Exercise-Induced Sirtuin Regulation: Vegans Differ from Omnivores and Lacto-Ovo Vegetarians." Nutrients 12, no. 4 (2020): 1004. http://dx.doi.org/10.3390/nu12041004.

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Both nutrition and exercise are known to affect metabolic regulation in humans. Sirtuins are essential regulators of cellular energy metabolism; SIRT1, SIRT3, and SIRT4 have a direct effect on glycolysis, oxidative phosphorylation, and fatty acid oxidation. This cross-sectional study investigates the effect of different diets on exercise-induced regulation of sirtuins. SIRT1 and SIRT3–SIRT5 were measured in blood from omnivorous, lacto-ovo vegetarian, and vegan recreational runners (21–25 subjects, respectively) before and after exercise at the transcript, protein, and enzymatic levels. SIRT1,

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Ki, Byeong Seong, Miree Park, Yunmi Woo, Woo Sik Lee, Jung Jae Ko, and Youngsok Choi. "Expression of Sirt1, Sirt2, Sirt5, and Sirt6 in the Mouse Testis." Reproductive and developmental Biology 39, no. 2 (2015): 43–47. http://dx.doi.org/10.12749/rdb.2015.39.2.43.

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Kitada, Munehiro, Shinji Kume, Ai Takeda-Watanabe, Keizo Kanasaki, and Daisuke Koya. "Sirtuins and renal diseases: relationship with aging and diabetic nephropathy." Clinical Science 124, no. 3 (2012): 153–64. http://dx.doi.org/10.1042/cs20120190.

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Sirtuins are members of the Sir2 (silent information regulator 2) family, a group of class III deacetylases. Mammals have seven different sirtuins, SIRT1–SIRT7. Among them, SIRT1, SIRT3 and SIRT6 are induced by calorie restriction conditions and are considered anti-aging molecules. SIRT1 has been the most extensively studied. SIRT1 deacetylates target proteins using the coenzyme NAD+ and is therefore linked to cellular energy metabolism and the redox state through multiple signalling and survival pathways. SIRT1 deficiency under various stress conditions, such as metabolic or oxidative stress

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Ageel, Dawi Muftah. "Environmental Study about Sirte Sabkhas Impact on The Surface Salinity at Western Coastal of Libya Using MODIS Satellite Techniques." مجلة علوم البحار والتقنيات البيئية 9, no. 2 (2023): 11–24. http://dx.doi.org/10.59743/jmset.v9i2.144.

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In this study, MODIS sensor techniques were used because of their quality images, and their data is available for seven years (2015-2021) to surface salinity in the study area. It was discovered that Sirte Sabkhas contributed to the surface salinity of the Libyan western coast. Surface salinity degrees were more intense in the summer and spring seasons and less in the winter and autumn seasons due to the feeding of Sirte Sabkhas. The south, southeast, and southwest winds had an important role in Sirte Sabkhas's effect on surface salinity on the western coast. The differences between salinity v

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Wyman, Anne E., Zahid Noor, Rita Fishelevich, et al. "Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts." American Journal of Physiology-Lung Cellular and Molecular Physiology 312, no. 6 (2017): L945—L958. http://dx.doi.org/10.1152/ajplung.00473.2016.

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Pulmonary fibrosis is a severe condition with no cure and limited therapeutic options. A better understanding of its pathophysiology is needed. Recent studies have suggested that pulmonary fibrosis may be driven by accelerated aging-related mechanisms. Sirtuins (SIRTs), particularly SIRT1, SIRT3, and SIRT6, are well-known mediators of aging; however, limited data exist on the contribution of sirtuins to lung fibrosis. We assessed the mRNA and protein levels of all seven known sirtuins in primary lung fibroblasts from patients with idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-asso

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Carbone, Annalucia, Natalia Linkova, Victoria Polyakova, et al. "Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies." International Journal of Molecular Sciences 21, no. 21 (2020): 8134. http://dx.doi.org/10.3390/ijms21218134.

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Melatonin (MT) and sirtuins (SIRT) are geroprotective molecules that hold back the aging process and the development of age-related diseases, including cardiovascular pathologies. Buccal epithelium (BE) sampling is a non-invasive procedure, yielding highly informative material for evaluating the expression of genes and proteins as well as the synthesis of molecules. Among these, MT and SIRTs are valuable markers of the aging process and age-related pathologies. The purpose of this study was to examine age-related expression patterns of these signaling molecules, in particular MT, SIRT1, SIRT3,

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Aitbaev, K. A., I. T. Murkamilov, Zh A. Murkamilova, I. O. Kudaibergenova, and F. A. Yusupov. "Epigenetic Mechanisms of Cardioprotection: Focus is on Activation of Sirtuins." Russian Archives of Internal Medicine 11, no. 6 (2021): 424–32. http://dx.doi.org/10.20514/2226-6704-2021-11-6-424-432.

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Oxidative stress is a common sign of aging and cardiovascular disease (CVD), including atherosclerosis, heart failure, hypertension, diabetes mellitus and other diseases of the vascular system. In this regard, in recent years, researchers have shown increased interest in sirtuins (SIRTs) — stress adapters and epigenetic enzymes involved in cellular mechanisms for controlling age-related pathologies, cancer and CVD. Among sirtuins, of which there are seven in mammals (SIRT1-SIRT7), SIRT1 and SIRT6 possess the most cardioprotective, anti-inflammatory, atheroprotective and anti-aging properties.

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Sygitowicz, Grażyna, and Dariusz Sitkiewicz. "Sirtuins and their role as physiological modulators of metabolism." Postępy Higieny i Medycyny Doświadczalnej 74 (November 17, 2020): 489–97. http://dx.doi.org/10.5604/01.3001.0014.5247.

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The sirtuins are a family of highly evolutionary conserved NAD+-dependent deacetylases (SIRT1, 2, 3, 5). Certain human sirtuins (SIRT4, 6) have, in addition, an ADP-ribosyltransferase activity. SIRT1 and SIRT2 are located in the nucleus and cytoplasm; SIRT3 exists predominantly in mitochondria, and SIRT6 is located in the nucleus. The mammalian sirtuins have emerged as key metabolic sensors that directly link environmental nutrient signals to metabolic homeostasis. SIRT1 is involved in the regulation of gluconeogenesis and fatty acid oxidation, as well as inhibiting lipogenesis and inflammatio

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Chowdhury, Sarwat, Smitha Sripathy, Alyssa A. Webster, et al. "Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies." Molecules 25, no. 3 (2020): 455. http://dx.doi.org/10.3390/molecules25030455.

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Genetic ablation as well as pharmacological inhibition of sirtuin 2 (SIRT2), an NAD+-dependent protein deacylase, have therapeutic effects in various cancers and neurodegenerative diseases. Previously, we described the discovery of a dual SIRT1/SIRT2 inhibitor called cambinol (IC50 56 and 59 µM, respectively), which showed cytotoxic activity against cancer cells in vitro and a marked anti-proliferative effect in a Burkitt lymphoma mouse xenograft model. A number of recent studies have shown a protective effect of SIRT1 and SIRT3 in neurodegenerative and metabolic diseases as well as in certain

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Chiang, Ying-Ling, and Hening Lin. "An improved fluorogenic assay for SIRT1, SIRT2, and SIRT3." Organic & Biomolecular Chemistry 14, no. 7 (2016): 2186–90. http://dx.doi.org/10.1039/c5ob02609a.

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We report an improved fluorogenic assay for SIRT1, SIRT2, and SIRT3 using a myristoyl peptide with a C-terminal aminocoumarin. The assay requires less substrate, yields high signal-to-background ratios andZ′ values, and thus will expedite high-throughput screening for modulators of SIRT1, SIRT2, and SIRT3.

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Batalha, Isadora Maria, Camilo Andres P. Peña-Bello, and Luis Fernando F. Schütz. "PSV-4 Effects of Asprosin on Nuclear Sirtuins Expression in Bovine Granulosa Cells." Journal of Animal Science 101, Supplement_3 (2023): 403–4. http://dx.doi.org/10.1093/jas/skad281.479.

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Abstract Asprosin is an adipokine that regulates steroid production in granulosa cells (GC). Sirtuins are a family of NAD+-dependent deacetylases associated with GC function. In the nucleus, sirtuins are epigenetic regulators of gene expression. Although the literature shows that sirtuins and asprosin affect GC steroidogenesis and proliferation, studies are required to investigate whether their actions are linked. The aims of this study are to determine the influence of asprosin on mRNA expression of nuclear sirtuins and their association with steroidogenic regulators in bovine GC. GC were iso

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Jagannath, Chinnaswamy, Vipul Singh, Abhishek Mishra, Arshad Khan, and Kangling Zhang. "Mycobacterium tuberculosis reduces global histone acetylation in human macrophages which is restored by Sirtuin inhibitors." Journal of Immunology 208, no. 1_Supplement (2022): 110.05. http://dx.doi.org/10.4049/jimmunol.208.supp.110.05.

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Abstract Mycobacterium tuberculosis (Mtb) infects and grows in human macrophages unless they are activated earlier using IFN-γ. IFN-γ polarized M1-Macrophages (MΦs) and IL-4 driven M2-MΦs respectively kill Mtb or are permissive. Mtb infected M1-MΦs showed an increased expression of iNOS and autophagy-regulating ATGs compared to M2-MΦs. Despite increased bactericidal function, M1-MΦs were unable to eradicate Mtb. Hypothesis Because M1- and M2-MΦs differentially expressed Sirtuin1, 2, 3 and Sirt5, we hypothesized that, Sirtuin-dependent histone deacetylation would affect gene expression and bact

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Manetti, Mirko, Irene Rosa, Bianca Saveria Fioretto, Marco Matucci-Cerinic, and Eloisa Romano. "Decreased Serum Levels of SIRT1 and SIRT3 Correlate with Severity of Skin and Lung Fibrosis and Peripheral Microvasculopathy in Systemic Sclerosis." Journal of Clinical Medicine 11, no. 5 (2022): 1362. http://dx.doi.org/10.3390/jcm11051362.

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Systemic sclerosis (SSc, scleroderma) is a severe autoimmune connective tissue disease characterized by widespread peripheral microvasculopathy, and progressive cutaneous and visceral fibrosis, leading to significant organ dysfunction. Sirtuins (SIRTs) are a family of NAD-dependent protein deacetylases with pleiotropic effects on a variety of biological processes, including metabolism, cell survival, and aging. In the last decades, increasing studies have explored the contribution of SIRTs to the pathogenesis of SSc, highlighting a significant antifibrotic effect of both SIRT1 and SIRT3. On th

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Fu, Weiwei, Hong Li, Haiyang Fu, et al. "The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response." Journal of Immunology Research 2020 (November 17, 2020): 1–12. http://dx.doi.org/10.1155/2020/8820355.

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The sirtuins (SIRTs), including seven family members, belong to class III histone deacetylase (HDAC) enzymes, which have been intensively investigated in cancers. Although the function of SIRTs in the cancer immunology is explored, SIRT-specific mechanisms regulating necroptosis-related innate immune response are not clear. In our present study, we found that both the mRNA and protein expression levels of SIRT3 and SIRT6 are significantly increased in the PCa tissues (HR, CI P = 3.30 E − 03 ; HR, CI P = 2.35 E − 08 ; and HR, CI P = 9.20 E − 08 ) and were associated with patients’ Gleason score

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Elhudairi, Abdelsalam Mohamed, and Hüseyin Işiksal. "The Role of ISIS as a Religious Terrorist Group in the Instability of Libya in the Post-Gaddafi Era: The Case of Sirte." Religions 13, no. 6 (2022): 516. http://dx.doi.org/10.3390/rel13060516.

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Stability and security remain the two most important objectives in the post-Gaddafi era since no accord has established a legitimate government in Libya yet. The rivalry of the Tripoli and Tobruk governments has resulted in unabating state insecurity in Libya. This article focuses on the strategic city of Sirte where the insecurity was felt most in the post-Gaddafi era. The significance of this city also comes from its strategic location, which makes it the main target for the political actors that want to control Libya. Deriving from these points, this article analyzes the impact and threat o

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Gumati, Y. D., and A. E. M. Nairn. "TECTONIC SUBSIDENCE OF THE SIRTE BASIN, LIBYA." Journal of Petroleum Geology 14, no. 1 (1991): 93–102. http://dx.doi.org/10.1111/j.1747-5457.1991.tb00301.x.

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Martín-Ramírez, Rita, Rebeca González-Fernández, Jairo Hernández, Pablo Martín-Vasallo, Angela Palumbo, and Julio Ávila. "Celastrol and Melatonin Modify SIRT1, SIRT6 and SIRT7 Gene Expression and Improve the Response of Human Granulosa-Lutein Cells to Oxidative Stress." Antioxidants 10, no. 12 (2021): 1871. http://dx.doi.org/10.3390/antiox10121871.

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An excess of oxidative stress (OS) may affect several physiological processes fundamental to reproduction. SIRT1, SIRT6 and SIRT7 are involved in protection stress systems caused by OS, and they can be activated by antioxidants such as celastrol or melatonin. In this study, we evaluate SIRT1, SIRT6 and SIRT7 gene expression in cultured human granulosa-lutein (hGL) cells in response to OS inductors (glucose or peroxynitrite) and/or antioxidants. Our results show that celastrol and melatonin improve cell survival in the presence and absence of OS inductors. In addition, melatonin induced SIRT1,

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Carpenter, Chris. "3D Geological Model Creates Potential for Increased Production in Libyan Field." Journal of Petroleum Technology 73, no. 08 (2021): 44–45. http://dx.doi.org/10.2118/0821-0044-jpt.

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This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 201417, “Reservoir Characterization and Geostatistical Model of the Cretaceous and Cambrian-Ordovician Reservoir Intervals, Meghil Field, Sirte Basin, Libya,” by Mohamed Masoud, Sirte Oil Company; W. Scott Meddaugh, SPE, Midwestern State University; and Masud Eljaroshi Masud, Sirte Oil Company, prepared for the 2020 SPE Annual Technical Conference and Exhibition, originally scheduled to be held in Denver, Colorado, 5–7 October. The paper has not been peer reviewed. The study outlined in the complet

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Aksungur, Nurhak, Murat Kizilkaya, Necip Altundaş та ін. "Molecular Crosstalk Between SIRT1, Wnt/β-Catenin Signaling, and Inflammatory Pathways in Renal Transplant Rejection: Role of miRNAs, lncRNAs, IL-1, IL-6, and Tubulointerstitial Inflammation". Medicina 61, № 6 (2025): 1073. https://doi.org/10.3390/medicina61061073.

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Background/Objectives: This study aimed to evaluate the relationship between sirtuin family members (SIRT1, SIRT3, and SIRT6) and Wnt/β-catenin pathways with inflammation during the rejection process following kidney transplantation, as well as to explore their potential roles as candidate biomarkers. Materials and Methods: Blood samples were collected from 35 kidney transplant rejection patients and 30 healthy controls. The gene expression levels of SIRT1, SIRT3, SIRT6, and Wnt/β-catenin pathway components were measured using real-time PCR, and miRNA and lncRNA expression levels were analyzed

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