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Dissertations / Theses on the topic 'SIRV2'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Hjort, Karin. "The cell cycle of the hyperthermophilic archaeal genus Sulfolobus." Doctoral thesis, Uppsala universitet, Institutionen för cell- och molekylärbiologi, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3010.

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The third domain of life, Archaea is one of the three main evolutionary lineages together with the Bacteria and the Eukarya domains. The archaea are, despite their prokaryotic cell organisation, more closely related to eukaryotes than to bacteria in terms of the informational pathways (DNA replication, transcription and translation). Organisms from the archaeal hyperthermophilic genus Sulfolobus thrives in a hot (80°C), acidic (pH 2-4) and sulphur-rich environment. In my thesis, I have used a variety of different approaches to study the Sulfolobus cell cycle. After dilution of a stationary pha

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2

Pelve, Erik A. "Unique Solutions to Universal Problems : Studies of the Archaeal Cell." Doctoral thesis, Uppsala universitet, Molekylär evolution, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-162886.

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Archaea is one of the three domains of life and studies of archaeal biology are important for understanding of life in extreme environments, fundamental biogeochemical processes, the origin of life, the eukaryotic cell and their own, unique biology. This thesis presents four studies of the archaeal cell, using the extremophilic Sulfolobus and ocean living Nitrosopumilus as model systems. Cell division in crenarchaea is shown to be carried out by a previously unknown system named Cdv (cell division). The system shares homology with the eukaryotic ESCRT-III system which is used for membrane reor

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3

Lucindo, Emy Soares. "Para qué sirve este diccionario?" reponame:Repositório Institucional da UFSC, 2008. http://repositorio.ufsc.br/xmlui/handle/123456789/91762.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Estudos da Tradução, Florianópolis, 2008<br>Made available in DSpace on 2012-10-24T02:16:31Z (GMT). No. of bitstreams: 1 269230.pdf: 1487167 bytes, checksum: 68b302a056934bedbe322a0fa0ad90ca (MD5)<br>El diccionario bilingüe está entre las herramientas más utilizadas por los estudiantes de lenguas extranjeras. Sin embargo, no todos saben cómo usarlo adecuadamente. Parte de los autores del área de lexicografía pedagógica abogan por la enseñanza del uso del diccionario,

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4

Tavares, Joana Alexandra Pinto da Costa. "Antileishmanial Drugs: search for t SIR2 inhibitors." Tese, Faculdade de Farmácia da Universidade do Porto, 2007. http://hdl.handle.net/10216/10804.

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Doutoramento em Bioquímica<br>PhD Degree - Biochemistry<br>A leishmaniose é uma doença parasitária causada pelo protozoário do género Leishmania, que afecta milhões de indivíduos, em particular nas regiões tropicais e subtropicais, sendo deste modo responsável por uma elevada mortalidade e morbilidade. Na ausência de vacinas para uso humano, o controlo da doença baseia-se na terapêutica farmacológica. No entanto, os medicamentos disponíveis não são satisfatórios principalmente devido ao aparecimento de resistências, aos efeitos laterais indesejáveis, e sobretudo devido à sua eficácia ser limit

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Tavares, Joana Alexandra Pinto da Costa. "Antileishmanial Drugs: search for t SIR2 inhibitors." Doctoral thesis, Faculdade de Farmácia da Universidade do Porto, 2007. http://hdl.handle.net/10216/10804.

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Doutoramento em Bioquímica<br>PhD Degree - Biochemistry<br>A leishmaniose é uma doença parasitária causada pelo protozoário do género Leishmania, que afecta milhões de indivíduos, em particular nas regiões tropicais e subtropicais, sendo deste modo responsável por uma elevada mortalidade e morbilidade. Na ausência de vacinas para uso humano, o controlo da doença baseia-se na terapêutica farmacológica. No entanto, os medicamentos disponíveis não são satisfatórios principalmente devido ao aparecimento de resistências, aos efeitos laterais indesejáveis, e sobretudo devido à sua eficácia ser limit

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6

Otten, Daniela [Verfasser]. "Funktion der Deacetylase SIRT2 in neurodegenerativen Erkrankungen / Daniela Otten." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2013. http://d-nb.info/1033850632/34.

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7

Silvestre, Ricardo Jorge Leal. "Leishmania SIR2 : host cell interactions and vaccinal approaches." Tese, Porto : [Edição do Autor], 2007. http://catalogo.up.pt/F?func=find-b&local_base=UPB01&find_code=SYS&request=000094989.

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8

Silvestre, Ricardo Jorge Leal. "Leishmania SIR2 : host cell interactions and vaccinal approaches." Doctoral thesis, Porto : [Edição do Autor], 2007. http://hdl.handle.net/10216/64002.

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9

Reiss, Martina [Verfasser]. "Characterization of Sirt2 using conditional RNAi in mice / Martina Reiss." Köln : Universitäts- und Stadtbibliothek Köln, 2011. http://d-nb.info/1013805356/34.

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10

Sima, Teruel Núria. "Paper de SirT2 en el control epigenètic de la mitosi." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/386527.

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La cromatina és una estructura nucleoproteica, dinàmica i jeràrquicament organitzada dins del nucli cel•Iular. La seva estructura, organització i funció està controlada al llarg del cicle cel.lular, per processos epigenètics que produeixen canvis heretables que no afecten la seqüència de DNA. Entre aquests canvis es troben la metilació del DNA, les modificacions postraduccionals de les histones i desplegament de la cromatina orquestrat pels complexes remodeladors i proteïnes estructurals. Les modificacions postraduccionals de les histones es donen principalment de forma dinàmica i regulada a

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11

Flick, Franziska [Verfasser]. "Regulation of the NAD+-dependent deacetylase SIRT2 by CDK5 / Franziska Flick." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2013. http://d-nb.info/1032894539/34.

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12

Epstein, Richard A. "¿La literatura sirve como ciencia social? : el caso de George Orwell." IUS ET VERITAS, 2015. http://repositorio.pucp.edu.pe/index/handle/123456789/122877.

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13

Chand, Thakuri Bal Krishna, and Dhirendra Kumar. "SIR2 DEACETYLASE ENZYME AND ITS POSSIBLE ROLE IN PATHOGEN INFECTION." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/208.

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Silent Information Regulator 2 (SIR2) have a phylogenetically conserved catalytic domain from bacteria to humans. It catalyzes NAD+ dependent deacetylase activity post-translationally on acetylated lysine residues present in the protein. Because SIR2 are NAD+ dependent, its activity gets influenced by the change in the level of NAD+. SIR2 is responsible for calorie restriction and increased replicative yeast lifespan. It breakdown high energy bond in nicotinamide adenine dinucleotide (NAD), and the synthesis of O-acetyl-ADP-ribose which is a novel product. Lysine de/acetylation of histone mole

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14

Bobrowska, Anna. "Validation of HDAC6 and SIRT2 tubulin deacetylases as therapeutic targets for Huntington's disease." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/validation-of-hdac6-and-sirt2-tubulin-deacetylases-as-therapeutic-targets-for-huntingtons-disease(be8927be-820e-4e72-be61-ef5928102c79).html.

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Since the identification of a widespread transcriptional dysregulation that occurs in Huntington's disease (HD), histone deacetylase (HDAC) inhibition has been explored as a possible therapeutic strategy for this devastating disease. Studies using broadrange acting HDAC inhibitors have shown great promise in HD mouse models. Concomitantly, effects of inhibition of individual HDACs have been investigated, however, these experiments have been most frequently performed in worm, fly, and cell and less so in mouse models of HD. Previous reports have demonstrated disease modifying potential for both

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15

Guadalupe, Báscones Julio. "Operador económico autorizado : cuando el control aduanero sirve a los fines de la facilitación." IUS ET VERITAS, 2015. http://repositorio.pucp.edu.pe/index/handle/123456789/123267.

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16

Armstrong, Christopher Mark 1972. "Characterization of the histone deacetylation activity of the yeast silencing gene SIR2." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/8210.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2001.<br>Includes bibliographical references.<br>A gene's location in the genome can have profound effects on its ekpression. In Saccharomyces cerevisiae, the gene SIR2 is crucial for silencing at the HM mating type loci, the telomeres, and the rDNA array. It is also necessary for maintaining a hypoacetylated state of the histones at these locations. To silence genes, the Sir2 protein can deacetylate histones in the presence of NAD+. This is shown by the ability of Sir2p to remove the acetyl groups from peptides correspo

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17

Grohmann, Theresa, Melanie Penke, Stefanie Petzold-Quinque, et al. "Inhibition of NAMPT sensitizes MOLT4 leukemia cells for etoposide treatment through the SIRT2-p53 pathway." Elsevier, 2018. https://ul.qucosa.de/id/qucosa%3A38590.

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NAMPT (Nicotinamide phosphoribosyltransferase) catalyses the rate-limiting step in the NAD biosynthesis from nicotinamide and thereby regulates the activity of NAD-dependent enzymes. Cancer cells are highly dependent on NAD for energy and DNA repair processes and are assumed to be more susceptible to an inhibition of NAD synthesis than non-transformed cells. We aimed to investigate whether or not inhibition of NAMPT with its specific inhibitor FK866 can sensitize leukemia cells for chemotherapeutic agents. NAMPT protein abundance, enzymatic activity and NAD concentrations were significantly hi

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18

Wilson, Jeanne Marie. "A genetic and biochemical characterization of HST2, a SIR2 homolog in budding yeast." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3198867.

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Thesis (Ph. D.)--University of California, San Diego, 2006.<br>Title from first page of PDF file (viewed May 2, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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19

Fackler, Joseph R. "The characterization of lytic viruses infecting the hyperthermophilic Sulfolobus islandicus isolated from Yellowstone National Park." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439301849.

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20

Thakuri, Bal Krishna Chand. "SIP-428, a SIR2 Deacetylase Enzyme and Its Role in Biotic Stress Signaling Pathway." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etd/3505.

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SABP2 (Salicylic Acid Binding Protein 2) plays a vital role in the salicylic acid signaling pathway of plants both regarding basal resistance and systemic acquired resistance against pathogen infection. SIP-428 (SABP2 Interacting Protein-428) is a Silent information regulator 2 (SIR2) like deacetylase enzyme that physically interacts with SABP2 in a yeast two-hybrid interaction and confirmed independently by a GST pull-down assay. We demonstrated that SIP- 428 is an NAD+ dependent SIR2 deacetylase enzyme. Transgenic tobacco plants silenced in SIP- 428 expression via RNAi showed enhanced basal

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21

Vergnes, Baptiste. "Caractérisation moléculaire et fonctionnelle de la protéine SIR2 cytosolique du parasite Leishmania : applications thérapeutiques potentielles." Montpellier 2, 2004. http://www.theses.fr/2004MON20012.

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22

Hoppe, Georg J. "The role of Sir2's enzymatic activity in the assembly of silencing complexes in budding yeast." [S.l. : s.n.], 2002. http://www.diss.fu-berlin.de/2002/280/index.html.

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23

Arango, Lievano Margarita Maria. "Rôles physiopathologiques des anomalies de la régulation de la transcription dans la maladie de Huntington : étude des effets neuroprotecteurs de CA150 et de SIR-2." Paris 6, 2006. http://www.theses.fr/2006PA066139.

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La maladie de Huntington est une maladie neurodŽgŽnŽrative causŽe par des polyglutamines mutŽes. Les altŽrations de la rŽgulation de la transcription passant par des interactions entre la huntingtine mutŽe (htt-m) et plusieurs facteurs de transcription serait un mŽcanisme physipathologique majeur. L'interaction entre le cofacteur de transcription CA150 et la htt avait ŽtŽ mise en Žvidence au laboratoire. Son accumulation dans le cerveau des patients ainsi que son influence sur l'‰ge d'apparition de la maladie suggŽraient que CA150 pouvait avoir un r™le dans la maladie. Nous avons montrŽ que la

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24

Nohoesu, Oviavo. "Characterization of SABP2-Interacting Proteins (SIP) 428: an NAD+-Dependent Deacetylase Enzyme in Plant Abiotic Stress Signaling." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/etd/3961.

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Abiotic stress leads to a change in the water content of plants. Salinity and osmotic stress affect both the morphology and physiology of plants. Plants have therefore responded to these environmental changes by adapting and tolerating them. The SABP2-interacting proteins (SIP) 428-silenced RNAi transgenic tobacco lines were subjected to various abiotic stresses (salinity, osmotic, and drought). The effect of SIP428-silencing on the tobacco plants subjected to these abiotic stresses was monitored. The results from the root growth data show that the sip428-silenced lines exhibit enhanced tolera

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25

Vojacek, Steffen [Verfasser], Andreas [Akademischer Betreuer] Link, Andreas [Gutachter] Link, and Markus [Gutachter] Schlitzer. "Synthese und Charakterisierung von SIRT2-Inhibitoren als epigenetische Modulatoren / Steffen Vojacek ; Gutachter: Andreas Link, Markus Schlitzer ; Betreuer: Andreas Link." Greifswald : Universität Greifswald, 2018. http://d-nb.info/1179914104/34.

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26

Schulz, Laura Katharina Elisabeth. "Towards personalised therapy in oesophageal adenocarcinoma (from the LEO trial to the identification of SIRT2 as an inflammatory modulator)." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708266.

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27

Vojacek, Steffen Verfasser], Andreas [Akademischer Betreuer] [Link, Andreas [Gutachter] Link, and Markus [Gutachter] Schlitzer. "Synthese und Charakterisierung von SIRT2-Inhibitoren als epigenetische Modulatoren / Steffen Vojacek ; Gutachter: Andreas Link, Markus Schlitzer ; Betreuer: Andreas Link." Greifswald : Universität Greifswald, 2018. http://nbn-resolving.de/urn:nbn:de:gbv:9-opus-24865.

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28

Vall-llaura, Espinosa Núria. "Estudi de la regulació redox de Sir2 en S. cerevisiae. Implicació de les glutaredoxines Grx3 i Grx4." Doctoral thesis, Universitat de Lleida, 2016. http://hdl.handle.net/10803/392158.

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En aquest treball s’ha demostrat que Sir2 es regula mitjançant el seu estat redox, sent l’oxidació de cisteïnes mitjançant glutatiolació, un mecanisme de regulació de la seva activitat. A més, s’ha descrit una nova funció per dues glutaredoxines monotiòliques, Grx3 i Grx4, com les tiolreductases fisiològiques de Sir2. Ambdues participen en el manteniment i la recuperació de l’estat redox de Sir2, corroborat també per la interacció física entre Grx3/4 i Sir2. L’absència de Grx3/4, però no de Trx1/Trx2, afecta negativament l’activitat de Sir2, mentre que la desglutatiolació per part de Grx

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29

Campos, Andia Oscar Keyvin, Lerzundi Jose Manuel Correa, and Duran Gonzalo Zevallos. "Implementar un sistema de infraestructura como servicio (iaas) en cloud computing que sirva de alojamiento al ERP en una empresa comercial." Master's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2016. http://hdl.handle.net/10757/592716.

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El presente trabajo toma como punto de inicio el crecimiento de la empresa ST S.A. Para los próximos cinco años ST S.A. se ha planteado importar mayor cantidad de maquinarias debido a la gran demanda en la compra de maquinarias que se ha experimentado en los últimos años en nuestro país; para ello tendrá que ampliar su línea de crédito con la matriz fábrica New Holland. Dos de los principales requerimientos de fábrica es de tener los EEFF de ST S.A. auditados por una firma internacional y que éstos sean emitidos mensualmente. Para poder cumplir con dicho requerimiento, STSA ha decidido optar

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30

Haq, Md I. "Characterization Of A Putative SIR2 Like Deacetylase And Its Role In SABP2 Dependent Salicylic Acid Mediated Pathways In Plant." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etd/2394.

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Salicylic Acid Binding Protein2 (SABP2) is an enzyme known to play important role in SA mediated pathway. SBIP-428 (SABP2 Interacting Protein-428), a SIR2 like deacetylase, has been found to interact with SABP2. We demonstrate that SBIP-428 functions as a Sirtuin deacetylase. We show that SBIP-428 itself is lysine acetylated. Interactions of a SBIP-428 with SABP2 also raised the possibility of SABP2 itself being lysine acetylated. The recombinant purified SABP2 or native partially purified SABP2 displayed no acetylation. In response to TMV infection, the expression of SBIP-428 was down regulat

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31

Pichardo, Sánchez Cristian Giovanni. "GENERACIÓN DE UN MANUAL BASADO EN CÓMPUTO FORENSE QUE SIRVA COMO SOPORTE EN EL PROCESO DE RECUPERACIÓN DE INFORMACIÓN EN DISCOS DUROS." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2017. http://hdl.handle.net/20.500.11799/106055.

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Tesina de Licenciatura<br>En el presente trabajo se detalla la generación de un manual basado en cómputo forense que sirva como soporte en el proceso de recuperación de información en discos duros, está dirigido para usuarios con conocimientos básicos de informática que en algún momento lleguen a perder información de sus discos duros y requieran recuperar dicha información o la gran mayoría de ella. En este trabajo se menciona el análisis, diseño e implementación del manual, así como los resultados obtenidos al aplicarlo; actualmente existen manuales orientados a recuperar información, sin em

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32

Petrilli, Guinart Alejandra. "Target validation for Neurofibromatosis Type 2 therapeutics." Doctoral diss., University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/6339.

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Neurofibromatosis type 2 (NF2) is a benign tumor disease of the nervous system. Development of bilateral vestibular schwannomas is characteristic of NF2; however patients frequently present schwannomas on other nerves, as well as meningiomas and ependymomas. Currently, there are no drug therapies for NF2. There is an urgent need for development of NF2 therapeutics and this dissertation presents two independent potential therapeutic targets. The disease is caused by mutations in the NF2 gene that encodes a tumor suppressor called merlin. Loss of merlin function is associated with increased acti

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33

Danioux, Chloe. "Régulateurs transcriptionnels chez les archées hyperthermophiles et leurs virus : analyse moléculaire, fonctionnelle et génétique." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2014. http://tel.archives-ouvertes.fr/tel-00966549.

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Chez les Archaea, tous les processus informationnels, transcription incluse, sont effectués par des protéines proches de celles des Eukarya. Alors que la machinerie transcriptionnelle des archées a été bien caractérisée structurellement et fonctionnellement, très peu d'informations sont disponibles sur la régulation de son activité. En travaillant à la fois avec des modèles cellulaires (crénarchée hyperthermophile Sulfolobus islandicus) et viraux, nous avons pu réaliser une étude approfondie de trois régulateurs transcriptionnels et mieux comprendre les mécanismes de régulation transcriptionne

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34

Hoffmann, Julia [Verfasser]. "Charakterisierung der molekularen Wirkmechanismen der Langlebigkeitsgene Sir2 und foxo und der epigenetischen Anpassungen an eine Nahrungsrestriktion in Drosophila melanogaster / Julia Hoffmann." Kiel : Universitätsbibliothek Kiel, 2017. http://d-nb.info/113750966X/34.

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Kabra, Neha. "A Potential Tumor Suppressive Role of SIRT1 in Cancer." Scholar Commons, 2010. https://scholarcommons.usf.edu/etd/1674.

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The NAD-dependent deacetylase SIRT1 regulates several factors involved in stress response and cell survival but its function in cancer is largely unknown. Research suggests that SIRT1 influences several transcription factors and molecules that are important components of pathways often deregulated in cancer. Our experiments have shown that SIRT1 knock down by short hairpin RNA accelerates tumor xenograft formation by HCT116 colon cancer cells, whereas SIRT1 overexpression inhibits tumor formation. We have also found that, pharmacological inhibition of SIRT1 stimulates cell proliferation under

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36

Gazi, Khaled S. "The Stability of Lytic Sulfolobus Viruses." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511858582145599.

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Yahiaoui, Bilel. "Clonage et caractérisation moléculaire d'un ADNc de Leishmania major codant pour une protéine homologue au rpoduit du gène SIR2 de Saccharomyces cerevisiae." Lille 1, 1995. http://www.theses.fr/1995LIL10103.

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Au cours de ce travail, nous avons caractérisé des antigènes du stade promastigote de L. Major se fixant sur une colonne de glutathion (LmGbp). Le sérum dirige contre ces antigènes (anti-LmGbp) a permis de montrer que ces molécules sont sécrétées par le parasite et qu'elles sont exprimées chez l'amastigote ainsi que chez d'autres espèces de Leishmania. Parmi ces molécules, une protéine de poids moléculaire apparent de 66 kDa (p66) est révélée par l'anti-LmGbp en Western-blot dans les extraits antigéniques de toutes les espèces testées. A l'aide de la technique d'immunofluorescence et de la mic

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38

Miranda, Dulanto Luis Miguel, and Nakasato Kei Alonso Takayama. "Implementación de una plataforma informática avanzada que sirva de soporte a los procesos que intervienen en la gestión de equipos médicos en establecimientos de salud peruanos." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2017. http://tesis.pucp.edu.pe/repositorio/handle/123456789/8805.

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El modelo de la actual estructura de la gestión de los establecimientos de salud del país no tiene desarrollado el aspecto tecnológico. Debido a lo anterior, existe un riesgo de que las inversiones realizadas se pierdan debido a la poca capacidad de manejo tecnológico actual. La problemática afecta directamente a los pacientes debido a la baja efectividad clínica, aumento de la morbilidad y uso del presupuesto en áreas no críticas. Por lo anterior, se busca tener un método que permita cuantificar las pérdidas y sobrecostos que se generan por no tener un modelo organizacional que incluya

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Krey, Lea Farina Magdalena [Verfasser], George [Akademischer Betreuer] Trendelenburg, George [Gutachter] Trendelenburg, Wolfgang [Gutachter] Brück, and Margarete [Gutachter] Schön. "Untersuchungen zur Rolle des Silent information regulator 2 (Sirt2) im experimentellen Schlaganfall in Mäusen / Lea Farina Magdalena Krey ; Gutachter: George Trendelenburg, Wolfgang Brück, Margarete Schön ; Betreuer: George Trendelenburg." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://d-nb.info/1192974948/34.

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Gerson, Rosalind J. "The Interaction Between Sir3 and Sir4 is Dispensable for Silent Chromatin Spreading in Budding Yeast." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32232.

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In Saccharomyces cerevisiae, telomeric and HM silencing requires the histone deacetylase Sir2 and the chromatin binding proteins Sir3 and Sir4, which interact to form the SIR complex. Silent chromatin formation begins with a nucleation step, followed by spreading of Sir proteins along chromatin. Overexpression of Sir3 extends silent chromatin domains, however the role of Sir protein interactions within silent chromatin extensions remains unknown. Here, we generated the Sir3 mutant, Sir3-4A, which cannot interact with Sir4 but is capable of forming silent chromatin extensions when overexpressed

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41

Grenetier, Sabrina. "Le complexe CTD Kinase-I est requis pour le maintien de l'intégrité du locus RDN1 chez la levure S. Cerevisiae." Paris 6, 2006. http://www.theses.fr/2006PA066271.

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Chez la levure S. Cerevisiae, le complexe CTDK-I a été initialement identifié comme étant impliqué dans la transcription catalysée par l’ARN polymérase II. Au laboratoire, nous avons montré que la kinase CTDK-I est également impliquée dans la transcription catalysée par l’ARN polymérase I (Pol I) (Bouchoux et al. , 2004). La Pol I transcrit un gène unique (ADNr) codant le précurseur 35S des ARN ribosomiques. Ce gène est répété 150 fois en tandem au niveau du locus RDN1 sur le chromosome XII. Le nombre de répétitions, normalement maintenu stable, peut être affecté, notamment en cas de défaillan

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Eskandarian, Haig Alexander. "Characterization of Histone H3 Lysine 18 deacetylation during infection with Listeria monocytogenes." Phd thesis, Université René Descartes - Paris V, 2013. http://tel.archives-ouvertes.fr/tel-00844134.

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Bacterial pathogens dramatically affect host cell transcription programs for their own profit, however the underlying mechanism in most cases remain elusive. While investigating the effects of listeria monocytogenes on histone modifications, we discovered a new transcription regulatory machanism by which the expression of genes is repressed, during infection. Upon infection by L. monocytogenes, the secret virulence factor, InlB, binds the c-Met receptor and activates signaling through PI3K/Akt. This signaling platform is necessary for causing the relocalization of the histone deacetylase, SIRT

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Medda, Federico. "Novel cambinol analogues as potential anticancer agents : an improved understanding of sirtuin isoform selectivity." Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/1839.

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SIRT1 and SIRT2 are two NAD⁺-dependent deacetylases which negatively modulate the activity of p53, a protein which is involved in cell cycle arrest, senescence and apoptosis following genotoxic stress. Part I of the thesis describes the exploration of the chemical space around a reported unselective and modest inhibitor of SIRT1 and SIRT2 with the aim of improving the selectivity and potency of the inhibitor against the two isoforms. Particular emphasis is placed upon understanding the mode of binding of the novel analogues within the active site of the enzymes. Chapter 1 reviews the physiolog

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Pascal, Frédéric. "Détection et Estimation en Environnement non Gaussien." Phd thesis, Université de Nanterre - Paris X, 2006. http://tel.archives-ouvertes.fr/tel-00128438.

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Dans le contexte très général de la détection radar, les détecteurs classiques, basés sur l'hypothèse d'un bruit Gaussien, sont souvent mis en défaut dès lors que l'environnement (fouillis de sol, de mer) devient inhomogène, voire impulsionnel, s'écartant très vite du modèle Gaussien. Des modèles physiques de fouillis basés sur les modèles de bruit composé (SIRP, Compound Gaussian Processes) permettent de mieux représenter la réalité (variations spatiales de puissance et nature de fouillis, transitions, ...). Ces modèles dépendent cependant de paramètres (matrice de covariance, loi de texture,

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Kessler, Alexandra [Verfasser]. "Untersuchungen zur Transkription der Genome der Rudiviren SIRV1 und SIRV2 des hyperthermophilen Archaeums Sulfolobus, in vivo und in vitro / vorgelegt von Alexandra Kessler." 2006. http://d-nb.info/978549716/34.

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Pandithage, Ruwin [Verfasser]. "Die humanen Sir2-Orthologe SIRT1 und SIRT2 als Substrate Cyklin-abhängiger Kinasen / vorgelegt von Ruwin Pandithage." 2006. http://d-nb.info/987922572/34.

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Bajurny, Sarah. "The echinoderm Sir2." 2007. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=958077&T=F.

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Khan, Ahlia Nisa. "Enzymatic properties of Sir2 proteins." 2006. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=449822&T=F.

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Gallo, Christopher M. "Molecular dissection of Sir2-dependent silencing /." 2005. http://wwwlib.umi.com/dissertations/fullcit/3161607.

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Smith, Brian Christopher. "Chemical mechanisms of Sir2 protein deacetylases." 2008. http://www.library.wisc.edu/databases/connect/dissertations.html.

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