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Journal articles on the topic 'SIRV2'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Mayo-Muñoz, David, Fei He, Jacob Jørgensen, Poul Madsen, Yuvaraj Bhoobalan-Chitty, and Xu Peng. "Anti-CRISPR-Based and CRISPR-Based Genome Editing of Sulfolobus islandicus Rod-Shaped Virus 2." Viruses 10, no. 12 (2018): 695. http://dx.doi.org/10.3390/v10120695.

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Genetic engineering of viruses has generally been challenging. This is also true for archaeal rod-shaped viruses, which carry linear double-stranded DNA genomes with hairpin ends. In this paper, we describe two different genome editing approaches to mutate the Sulfolobus islandicus rod-shaped virus 2 (SIRV2) using the archaeon Sulfolobus islandicus LAL14/1 and its derivatives as hosts. The anti-CRISPR (Acr) gene acrID1, which inhibits CRISPR-Cas subtype I-D immunity, was first used as a selection marker to knock out genes from SIRV2M, an acrID1-null mutant of SIRV2. Moreover, we harnessed the

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Prangishvili, David, Hans Peter Arnold, Dorothee Götz, et al. "A Novel Virus Family, the Rudiviridae: Structure, Virus-Host Interactions and Genome Variability of the Sulfolobus Viruses SIRV1 and SIRV2." Genetics 152, no. 4 (1999): 1387–96. http://dx.doi.org/10.1093/genetics/152.4.1387.

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Abstract The unenveloped, stiff-rod-shaped, linear double-stranded DNA viruses SIRV1 and SIRV2 from Icelandic Sulfolobus isolates form a novel virus family, the Rudiviridae. The sizes of the genomes are 32.3 kbp for SIRV1 and 35.8 kbp for SIRV2. The virions consist of a tube-like superhelix formed by the DNA and a single basic 15.8-kD DNA-binding protein. The tube carries a plug and three tail fibers at each end. One turn of the DNA-protein superhelix measures 4.3 nm and comprises 16.5 turns of B DNA. The linear DNA molecules appear to have covalently closed hairpin ends. The viruses are not l

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3

Birkenbihl, R. P., K. Neef, D. Prangishvili, and B. Kemper. "Holliday junction resolving enzymes of archaeal viruses SIRV1 and SIRV2." Journal of Molecular Biology 309, no. 5 (2001): 1067–76. http://dx.doi.org/10.1006/jmbi.2001.4761.

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4

Kessler, Alexandra, Arie B. Brinkman, John van der Oost, and David Prangishvili. "Transcription of the Rod-Shaped Viruses SIRV1 and SIRV2 of the Hyperthermophilic Archaeon Sulfolobus." Journal of Bacteriology 186, no. 22 (2004): 7745–53. http://dx.doi.org/10.1128/jb.186.22.7745-7753.2004.

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ABSTRACT The double-stranded DNA genomes of the crenarchaeal rudiviruses SIRV1 (32 kb) and SIRV2 (35 kb) were previously sequenced. Here we present results of the analysis of gene expression of these viruses at different time points after infection of the host cell, Sulfolobus islandicus, and of the mapping of transcriptional start sites. Transcription of both genomes starts simultaneously at multiple sites spread over the total length of the genome and from both strands. The earliest time point when viral transcripts could be detected in cells was 30 min after infection. At this time point al

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5

Evans, David J. "Exploitation of plant and archaeal viruses in bionanotechnology." Biochemical Society Transactions 37, no. 4 (2009): 665–70. http://dx.doi.org/10.1042/bst0370665.

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CPMV (cowpea mosaic virus), a plant virus, is a naturally occurring sphere-like nanoparticle, and is used as a synthon and/or template in bionanoscience. The virions formed by CPMV can be regarded as programmable nanobuilding blocks with a diameter of ∼30 nm. A range of molecules have been attached to this viral nanoscaffold, yielding stable nanoparticles that display multiple copies of the desired molecule. It has been shown that, in addition to surface amine groups, surface carboxy groups are also addressable, and a procedure has been developed that enables introduction of reactive thiols at

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6

Okutan, Ebru, Ling Deng, Saideh Mirlashari, et al. "Novel insights into gene regulation of the rudivirus SIRV2 infectingSulfolobuscells." RNA Biology 10, no. 5 (2013): 875–85. http://dx.doi.org/10.4161/rna.24537.

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7

Peng, Xu, Helmut Blum, Qunxin She, et al. "Sequences and Replication of Genomes of the Archaeal Rudiviruses SIRV1 and SIRV2: Relationships to the Archaeal Lipothrixvirus SIFV and Some Eukaryal Viruses." Virology 291, no. 2 (2001): 226–34. http://dx.doi.org/10.1006/viro.2001.1190.

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8

Ennifar, Eric, Jerôme Basquin, Rainer Birkenbihl, and Dietrich Suck. "Purification, crystallization and preliminary X-ray diffraction studies of the archaeal virus resolvase SIRV2." Acta Crystallographica Section F Structural Biology and Crystallization Communications 61, no. 5 (2005): 507–9. http://dx.doi.org/10.1107/s1744309105011528.

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9

Vestergaard, Gisle, Shiraz A. Shah, Ariane Bize, et al. "Stygiolobus Rod-Shaped Virus and the Interplay of Crenarchaeal Rudiviruses with the CRISPR Antiviral System." Journal of Bacteriology 190, no. 20 (2008): 6837–45. http://dx.doi.org/10.1128/jb.00795-08.

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ABSTRACT A newly characterized archaeal rudivirus Stygiolobus rod-shaped virus (SRV), which infects a hyperthermophilic Stygiolobus species, was isolated from a hot spring in the Azores, Portugal. Its virions are rod-shaped, 702 (± 50) by 22 (± 3) nm in size, and nonenveloped and carry three tail fibers at each terminus. The linear double-stranded DNA genome contains 28,096 bp and an inverted terminal repeat of 1,030 bp. The SRV shows morphological and genomic similarities to the other characterized rudiviruses Sulfolobus rod-shaped virus 1 (SIRV1), SIRV2, and Acidianus rod-shaped virus 1, iso

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10

Snyder, Jamie C., Benjamin Bolduc, Mary M. Bateson, and Mark J. Young. "The Prevalence of STIV c92-Like Proteins in Acidic Thermal Environments." Advances in Virology 2011 (2011): 1–6. http://dx.doi.org/10.1155/2011/650930.

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A new type of viral-induced lysis system has recently been discovered for two unrelated archaeal viruses, STIV and SIRV2. Prior to the lysis of the infected host cell, unique pyramid-like lysis structures are formed on the cell surface by the protrusion of the underlying cell membrane through the overlying external S-layer. It is through these pyramid structures that assembled virions are released during lysis. The STIV viral protein c92 is responsible for the formation of these lysis structures. We searched for c92-like proteins in viral sequences present in multiple viral and cellular metage

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11

Prangishvili, David, Eugene V. Koonin, and Mart Krupovic. "Genomics and biology of Rudiviruses, a model for the study of virus–host interactions in Archaea." Biochemical Society Transactions 41, no. 1 (2013): 443–50. http://dx.doi.org/10.1042/bst20120313.

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Archaeal viruses, especially viruses that infect hyperthermophilic archaea of the phylum Crenarchaeota, constitute one of the least understood parts of the virosphere. However, owing to recent substantial research efforts by several groups, archaeal viruses are starting to gradually reveal their secrets. In the present review, we summarize the current knowledge on one of the emerging model systems for studies on crenarchaeal viruses, the Rudiviridae. We discuss the recent advances towards understanding the function and structure of the proteins encoded by the rudivirus genomes, their role in t

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12

Dryden, Sylvia C., Fatimah A. Nahhas, James E. Nowak, Anton-Scott Goustin, and Michael A. Tainsky. "Role for Human SIRT2 NAD-Dependent Deacetylase Activity in Control of Mitotic Exit in the Cell Cycle." Molecular and Cellular Biology 23, no. 9 (2003): 3173–85. http://dx.doi.org/10.1128/mcb.23.9.3173-3185.2003.

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ABSTRACT Studies of yeast have shown that the SIR2 gene family is involved in chromatin structure, transcriptional silencing, DNA repair, and control of cellular life span. Our functional studies of human SIRT2, a homolog of the product of the yeast SIR2 gene, indicate that it plays a role in mitosis. The SIRT2 protein is a NAD-dependent deacetylase (NDAC), the abundance of which increases dramatically during mitosis and is multiply phosphorylated at the G2/M transition of the cell cycle. Cells stably overexpressing the wild-type SIRT2 but not missense mutants lacking NDAC activity show a mark

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13

Orange, F., A. Chabin, A. Gorlas, et al. "Experimental fossilisation of viruses from extremophilic Archaea." Biogeosciences 8, no. 6 (2011): 1465–75. http://dx.doi.org/10.5194/bg-8-1465-2011.

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Abstract. The role of viruses at different stages of the origin of life has recently been reconsidered. It appears that viruses may have accompanied the earliest forms of life, allowing the transition from an RNA to a DNA world and possibly being involved in the shaping of tree of life in the three domains that we know presently. In addition, a large variety of viruses has been recently identified in extreme environments, hosted by extremophilic microorganisms, in ecosystems considered as analogues to those of the early Earth. Traces of life on the early Earth were preserved by the precipitati

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14

North, Brian J., Brett L. Marshall, Margie T. Borra, John M. Denu, and Eric Verdin. "The Human Sir2 Ortholog, SIRT2, Is an NAD+-Dependent Tubulin Deacetylase." Molecular Cell 11, no. 2 (2003): 437–44. http://dx.doi.org/10.1016/s1097-2765(03)00038-8.

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15

Orange, F., A. Chabin, A. Gorlas, et al. "Experimental fossilisation of viruses from extremophilic Archaea." Biogeosciences Discussions 8, no. 2 (2011): 2235–57. http://dx.doi.org/10.5194/bgd-8-2235-2011.

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Abstract. The role of viruses at different stages of the origin of life has recently been reconsidered. It appears that viruses may have accompanied the earliest forms of life, allowing the transition from an RNA to a DNA world and possibly being involved in the shaping of tree of life in the three domains that we know presently. In addition, a large variety of viruses has been recently identified in extreme environments, hosted by extremophilic microorganisms, in ecosystems considered as analogues to those of the early Earth. The earliest traces of life were preserved by the precipitation of

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16

Jaubert, Carole, Chloë Danioux, Jacques Oberto, et al. "Genomics and genetics of Sulfolobus islandicus LAL14/1, a model hyperthermophilic archaeon." Open Biology 3, no. 4 (2013): 130010. http://dx.doi.org/10.1098/rsob.130010.

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The 2 465 177 bp genome of Sulfolobus islandicus LAL14/1, host of the model rudivirus SIRV2, was sequenced. Exhaustive comparative genomic analysis of S. islandicus LAL14/1 and the nine other completely sequenced S. islandicus strains isolated from Iceland, Russia and USA revealed a highly syntenic common core genome of approximately 2 Mb and a long hyperplastic region containing most of the strain-specific genes. In LAL14/1, the latter region is enriched in insertion sequences, CRISPR (clustered regularly interspaced short palindromic repeats), glycosyl transferase genes, toxin–antitoxin gene

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17

Acosta, María Luisa. "Los pueblos indígenas y afrodescendientes de Nicaragua:." Cuaderno Jurídico y Político 2, no. 5 (2016): 73–78. http://dx.doi.org/10.5377/cuadernojurypol.v2i5.11097.

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La Academia de Ciencias de Nicaragua, con esta oportunidad, me facilita la ocasión para reflexionar sobre lo que ha sido mi trabajo junto a los pueblos indígenas y afrodescendientes de Nicaragua en los últimos 24 años; pero no sólo sirve la ocasión para pensar sobre el aporte brindado en el desarrollo de la legislación y la jurisprudencia nacional e internacional en esta materia, sino que también sirva la ocasión para reflexionar sobre lo que esto ha significado para mí, como persona: ya que no se puede separar lo uno de lo otro.

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18

Leslie, Mitch. "SIRT2 stops cells." Journal of Cell Biology 180, no. 5 (2008): 847. http://dx.doi.org/10.1083/jcb.1805iti3.

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19

Tortorolo, Francisco, Florencia Farren, and Gabriel Rada. "Is melatonin useful for jet lag?" Medwave 15, s3 (2015): e6343-e6343. http://dx.doi.org/10.5867/medwave.2015.6343.

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20

Vera, Víctor Daniel Gil. "Sistema tutorial de aprendizaje y nivelación para aspirantes a PMP." Revista Perspectiva Empresarial 3, no. 1 (2016): 7. http://dx.doi.org/10.16967/rpe.98.

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La certificación Project Management Professional (PMP) permite a una persona desempeñar su labor y ser reconocida como directora profesional de proyectos; sirve para demostrar a empleadores, clientes y profesionales en un área, que se tiene el conocimiento, la experiencia y las habilidades necesarias para dirigir proyectos y lograr resultados satisfactorios. Este artículo tiene como objetivo desarrollar un sistema tutorial de aprendizaje para dispositivos móviles que sirva como herramienta de preparación a todos los aspirantes a la certificación PMP otorgada por el Project Management Institute

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21

Vera, Víctor Daniel Gil. "Sistema tutorial de aprendizaje y nivelación para aspirantes a PMP." Revista Perspectiva Empresarial 3, no. 1 (2016): 7. http://dx.doi.org/10.16967/rpe.v3n1a6.

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La certificación Project Management Professional (PMP) permite a una persona desempeñar su labor y ser reconocida como directora profesional de proyectos; sirve para demostrar a empleadores, clientes y profesionales en un área, que se tiene el conocimiento, la experiencia y las habilidades necesarias para dirigir proyectos y lograr resultados satisfactorios. Este artículo tiene como objetivo desarrollar un sistema tutorial de aprendizaje para dispositivos móviles que sirva como herramienta de preparación a todos los aspirantes a la certificación PMP otorgada por el Project Management Institute

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22

Matsushima, Shouji, and Junichi Sadoshima. "The role of sirtuins in cardiac disease." American Journal of Physiology-Heart and Circulatory Physiology 309, no. 9 (2015): H1375—H1389. http://dx.doi.org/10.1152/ajpheart.00053.2015.

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Modification of histones is one of the important mechanisms of epigenetics, in which genetic control is determined by factors other than an individual's DNA sequence. Sirtuin family proteins, which are class III histone deacetylases, were originally identified as gene silencers that affect the mating type of yeast, leading to the name “silent mating-type information regulation 2” (SIR2). They are characterized by their requirement of nicotinamide adenine dinucleotide for their enzyme activity, unlike other classes of histone deacetylases. Sirtuins have been traditionally linked to longevity an

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23

Leslie, M. "Shortchanged by Sir2." Science of Aging Knowledge Environment 2005, no. 47 (2005): nf87. http://dx.doi.org/10.1126/sageke.2005.47.nf87.

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24

Estrada-Mesa, Diego Alejandro. "What is the Purpose of a Philosophy of the Apparatuses?" Eidos, no. 29 (July 15, 2018): 68–98. http://dx.doi.org/10.14482/eidos.29.9315.

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25

Godoy, Sergio. "¿Para qué sirve Televisión Nacional?" Cuadernos.info, no. 10 (1995): 124–37. http://dx.doi.org/10.7764/cdi.10.296.

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26

Garske, Adam L., Brian C. Smith, and John M. Denu. "Linking SIRT2 to Parkinson’s Disease." ACS Chemical Biology 2, no. 8 (2007): 529–32. http://dx.doi.org/10.1021/cb700160d.

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27

Newton, Kim, Joanne M. Hildebrand, Zhirong Shen, et al. "Is SIRT2 required for necroptosis?" Nature 506, no. 7489 (2014): E4—E6. http://dx.doi.org/10.1038/nature13024.

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28

Pereira, Edgar, César M. Silva, and Jacques A. L. da Silva. "A generalized nonautonomous SIRVS model." Mathematical Methods in the Applied Sciences 36, no. 3 (2012): 275–89. http://dx.doi.org/10.1002/mma.2586.

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29

Nguyen, Phuongmai, Sudhanshu Shukla, Ryan Liu, Gopal Abbineni, and DeeDee K. Smart. "Sirt2 Regulates Radiation-Induced Injury." Radiation Research 191, no. 5 (2019): 398. http://dx.doi.org/10.1667/rr15282.1.

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30

Hong, Jun Young, Ian Robert Price, Jessica Jingyi Bai, and Hening Lin. "A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors." ACS Chemical Biology 14, no. 8 (2019): 1802–10. http://dx.doi.org/10.1021/acschembio.9b00384.

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31

Bedalov, Antonio, and Julian A. Simon. "Sir2 Flexes Its Muscle." Developmental Cell 5, no. 2 (2003): 188–89. http://dx.doi.org/10.1016/s1534-5807(03)00237-5.

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32

Lim, Jeaho, Juyoung Son, Jaewook Ryu, and Ja-Eun Kim. "SIRT2 Affects Primary Cilia Formation by Regulating mTOR Signaling in Retinal Pigmented Epithelial Cells." International Journal of Molecular Sciences 21, no. 6 (2020): 2240. http://dx.doi.org/10.3390/ijms21062240.

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SIRT2, a member of the Class III HDAC family, participates in diverse cellular processes and regulates several pathological conditions. Although a few reports show that SIRT2 regulates the cell cycle, the causes and outcomes of SIRT2-dependent cell proliferation remain unclear. Here, we examined the effects of SIRT2 suppression in human RPE1 cells using siRNA targeting SIRT2, and AK-1, a SIRT2-specific inhibitor. The number of primary cilia in SIRT2-suppressed cells increased under serum-present conditions. Suppressing SIRT2 induced cell cycle arrest at G0/G1 phase by inactivating mammalian ta

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He, Fang-Fang, Ren-Yu You, Chen Ye, et al. "Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2." Cellular Physiology and Biochemistry 46, no. 2 (2018): 451–60. http://dx.doi.org/10.1159/000488613.

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Background/Aims: Renal tubular epithelial cells and fibroblasts are the main sources of myofibroblasts, and these cells produce the extracellular matrix during tubulointerstitial fibrosis (TIF). Histone deacetylases (HDAC) inhibitors exert an antifibrogenic effect in the skin, liver and lung. Sirtuin 2 (SIRT2), which is a class III HDAC, is an important member of NAD+-dependent protein deacetylases. The current study evaluated the role of SIRT2 in renal TIF. Methods: Immunohistochemical staining and Western blot were performed to evaluate SIRT2 expression in TIF patients and unilateral urethra

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Wei, Ruojing, Dalin He, and Xinshi Zhang. "Role of SIRT2 in Regulation of Stemness of Cancer Stem-Like Cells in Renal Cell Carcinoma." Cellular Physiology and Biochemistry 49, no. 6 (2018): 2348–57. http://dx.doi.org/10.1159/000493835.

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Background/Aims: Cancer stem cells (CSCs) contribute to tumorgenesis, invasion and metastasis, and are typically resistant to chemotherapy. Recent reports showed that SIRT2 was upregulated in several cancers. However, whether SIRT2 may be a CSC marker in renal cell carcinoma (RCC) is not clear. Methods: The SIRT2 levels in both RCC samples and the corresponding normal kidney samples (NT) were assessed by RT-qPCR and ELISA. The association between SIRT2 levels and patient survival was examined using Bivariate correlation analysis by Spearman’s Rank Correlation Coefficients. The survival of the

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35

Singh, Preeti, Peter S. Hanson, and Christopher M. Morris. "Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration." Parkinson's Disease 2017 (2017): 1–17. http://dx.doi.org/10.1155/2017/2643587.

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Sirtuins are highly conserved lysine deacetylases involved in ageing, energy production, and lifespan extension. The mammalian SIRT2 has been implicated in Parkinson’s disease (PD) where studies suggest SIRT2 promotes neurodegeneration. We therefore evaluated the effects of SIRT2 manipulation in toxin treated SH-SY5Y cells and determined the expression and activity of SIRT2 in postmortem brain tissue from patients with PD. SH-SY5Y viability in response to oxidative stress induced by diquat or rotenone was measured following SIRT2 overexpression or inhibition of deacetylase activity, along with

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Rojas-Mezarina, Leonardo, Fiorella Inga-Berrospi, Leslie Trujillo, and Benjamín Castañeda Aphan. "Modelo innovador de tele-ecografía para zonas rurales en el Perú." Anales de la Facultad de Medicina 79, no. 1 (2018): 71. http://dx.doi.org/10.15381/anales.v79i1.14596.

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Uno de los principales retos de nuestro sistema sanitario es satisfacer las necesidades actuales y futuras del sector garantizando el acceso equitativo y de calidad a los servicios de salud, por lo que frente a esta necesidad surge el uso de las capacidades que brindan las tecnologías. Por ello, en este artículo se describe un modelo innovador de tele-ecografía (tele-ultrasonografía) implementado en diversas zonas rurales del Perú el cual consiste en un nuevo método de adquisición de imágenes a través de protocolos volumétricos asociados al correcto entrenamiento del operador, el uso de equipo

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Cacabelos, Ramón, Juan Carril, Natalia Cacabelos, et al. "Sirtuins in Alzheimer’s Disease: SIRT2-Related GenoPhenotypes and Implications for PharmacoEpiGenetics." International Journal of Molecular Sciences 20, no. 5 (2019): 1249. http://dx.doi.org/10.3390/ijms20051249.

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Sirtuins (SIRT1-7) are NAD+-dependent protein deacetylases/ADP ribosyltransferases with important roles in chromatin silencing, cell cycle regulation, cellular differentiation, cellular stress response, metabolism and aging. Sirtuins are components of the epigenetic machinery, which is disturbed in Alzheimer’s disease (AD), contributing to AD pathogenesis. There is an association between the SIRT2-C/T genotype (rs10410544) (50.92%) and AD susceptibility in the APOEε4-negative population (SIRT2-C/C, 34.72%; SIRT2-T/T 14.36%). The integration of SIRT2 and APOE variants in bigenic clusters yields

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38

Meneses, Cristina, and Gabriel Rada. "What are the effects of adding azathioprine to corticosteroids in polymyositis?" Medwave 15, Suppl1 (2015): e6179-e6179. http://dx.doi.org/10.5867/medwave.2015.6179.

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Jung, Yu Jin, Woong Park, Kyung Pyo Kang, and Won Kim. "SIRT2 is involved in cisplatin-induced acute kidney injury through regulation of mitogen-activated protein kinase phosphatase-1." Nephrology Dialysis Transplantation 35, no. 7 (2020): 1145–56. http://dx.doi.org/10.1093/ndt/gfaa042.

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Abstract Background Activation of mitogen-activated protein kinase phosphatase-1 (MKP-1), a dual-specificity protein phosphatase, regulates mitogen-activated protein kinase signaling. C-Jun N-terminal kinase (JNK) and p38 are activated in cisplatin-induced renal injury. However, the change of MKP-1 expression in cisplatin-induced renal injury and the regulatory effect of sirtuin 2 (SIRT2), a nicotinamide adenine dinucleotide–dependent deacetylase, on MKP-1 remains unknown. Methods To address these issues, we used constitutional Sirt2 knockout (KO) mice, transgenic (TG) mice with increased expr

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40

Martín Artiles, A., and Andreu Lope. "¿Sirve la formación para tener empleo?" Papers. Revista de Sociologia 58 (July 1, 1999): 39. http://dx.doi.org/10.5565/rev/papers/v58n0.1982.

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Zilberberg, Claude. "¿Para qué sirve la gramática tensiva?" Contratexto, no. 17 (2009): 103–35. http://dx.doi.org/10.26439/contratexto2009.n017.796.

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Leucona, Laura. "Para qué sirve una colección editorial." FENIX, no. 45 (December 30, 2020): 69–70. http://dx.doi.org/10.51433/fenix-bnp.2008.n45.p69-70.

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Fourcade, Stéphane, Tiago F. Outeiro, and Aurora Pujol. "SIRT2 in age-related neurodegenerative disorders." Aging 10, no. 3 (2018): 295–96. http://dx.doi.org/10.18632/aging.101397.

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Ríos-Alvarado, Arnaldo. "Editorial - ¿Para qué sirve la razón?" Entramado 16, no. 2 (2020): 8–9. http://dx.doi.org/10.18041/1900-3803/entramado.2.6799.

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En algún lugar del camino que hemos emprendido, y que vamos demarcando al transitarlo, nos vemos frente a dificultades sobre las cuales debemos reflexionar y definir el mejor camino que debemos tomar. Eso implica tomar la decisión acertada para continuar la senda trazada, lo cual no es fácil, porque solo el devenir en el espacio-tiempo, nos permitirá ver en el futuro si la decisión fue la correcta.

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Sayd, Salwa, Marie-Pierre Junier, and Hervé Chneiweiss. "SIRT2, une déacétylase aux multiples talents." médecine/sciences 30, no. 5 (2014): 532–36. http://dx.doi.org/10.1051/medsci/20143005016.

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46

Altomare, A., G. Cascarano, C. Giacovazzo, et al. "SIR92: a powerful direct methods package." Acta Crystallographica Section A Foundations of Crystallography 49, s1 (1993): c55. http://dx.doi.org/10.1107/s0108767378098402.

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Arteaga, Maribel, Na Shang, Xianzhong Ding, et al. "Inhibition of SIRT2 suppresses hepatic fibrosis." American Journal of Physiology-Gastrointestinal and Liver Physiology 310, no. 11 (2016): G1155—G1168. http://dx.doi.org/10.1152/ajpgi.00271.2015.

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Liver fibrosis can progress to cirrhosis and result in serious complications of liver disease. The pathogenesis of liver fibrosis involves the activation of hepatic stellate cells (HSCs), the underlying mechanisms of which are not fully known. Emerging evidence suggests that the classic histone deacetylases play a role in liver fibrosis, but the role of another subfamily of histone deacetylases, the sirtuins, in the development of hepatic fibrosis remains unknown. In this study, we found that blocking the activity of sirtuin 2 (SIRT2) by using inhibitors or shRNAs significantly suppressed fibr

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Zhang, Hui, PamelaSara E. Head, and David S. Yu. "SIRT2 orchestrates the DNA damage response." Cell Cycle 15, no. 16 (2016): 2089–90. http://dx.doi.org/10.1080/15384101.2016.1184517.

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Tang, Bor Luen, and Christelle En Lin Chua. "SIRT2, tubulin deacetylation, and oligodendroglia differentiation." Cell Motility and the Cytoskeleton 65, no. 3 (2008): 179–82. http://dx.doi.org/10.1002/cm.20253.

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Hofer, Ursula. "InlB uses SIRT2 to go nuclear." Nature Reviews Microbiology 11, no. 9 (2013): 596. http://dx.doi.org/10.1038/nrmicro3105.

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